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phenylmethylsiloxane copolymer
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of Medicine; *Department of Clinical Pathology, Tokai University School of Medicine
Diabetic Keratopathy A variety of cornea1 complications which occur in diabetics were briefly reviewed and the importance of the recognition of diabetic keratopathy was emphasized. This particular disease emerges and persists following the undue stress including intraocular surgery or photocoagulation. A varied degree of epithelial disturbance such as superficial punctate keratopathy, persistent epithelial defect, or recurrent cornea1 erosion can take place based on suppressed cell division, deturgence of barrier function, deterioration of basal cell adhesion, or decreased cornea1 sensitivity. Cornea1 endothelium also exhibits abnormalities in cell morphology including coefficient variation or percentages of hexagonal cells so that cornea1 edema tends to persist postoperatively. The involvement of the polyol pathway has been implicated in the pathogenesis of these disorders. (J Jpn Ophthalmol Sot 101:105-110,1997) Yuichi Ohashi Department of Ophthalmology, Ehime University School of Medicine
Emulsification Experiments with Dimethylsiloxane/Phenylmethylsiloxane Copolymer We compared the emulsification tendency of dimethylsiloxane/phenylmethylsiloxane copolymer (DPC; 5%-phenylated, specific gravity 0.984) with that of silicone oil (dimethylsiloxane; SO, specific gravity 0.966) and fluorosilicone oil (methyl-3,3,3-trifluoropropylsiloxane; FSO, specific gravity 1.256) which are clinically used as an intraocular tamponade. After SO, DPC and FSO were placed in a glass container with an equal amount of albumin solution (1 mg/ml) or y-globulin solution (1 mg/ml), and shaken SO and DPC, with their specific gravities being closer to water, showed less emulsification than FSO. Following vitrectomy, DPC was injected into the rabbit vitreous cavity, but did not seem to show any severe histological damage. Highly-phenylated DPC, which is slightly heavier than water, may be useful to treat inferior retinal detachment in place of FSO. (J Jpn Ophthalmol Sot lOl:lll-117,1997)
Jpn J Ophthalmol Vol41: 339-353.1997
Tsunehiko Ikeda,* Kimitoshi Nakamura,i Kenji Sakagami,* Hiroshi Iwahashi,” Koichi Sugimotojl Takehisa Matsuda,l and Yasuo Tano** *Department of Ophthalmology, Kyoto Prefecture University of Medicine; ?Nakamura Eye Clinic; fDepartment of Ophthalmology, Ehime University Medical School; “Department of Ophthalmology, Osaka Police Hospital; bugimoto Eye Clinic; ‘Department of Bioengineering, National Cardiovascular Center Research Institute; **Department of Ophthalmology, Osaka University Medical School
Ornithine Induced Retinopathy in the Rat: 1. Histopathological Study on the Retinal Pigment Epithelium An intravitreal injection of a small amount of l-ornithine hydrochloride damages the retinal pigment epithelium (RPE) selectively in monkey eyes. In this paper, we examined the rat eye and observed similar results. Clinically, retinal edema appeared immediately after injection and showed hyperfluorescence on a fluorescein angiograph after 3 days. Histopathologically, RPE showed marked swelling 3 hours after injection, then became necrotic and disappeared gradually. One month after injection, retinal structure was maintained in the area where RPE regenerated to cover Bruch’s membrane, but in the area where RPE cells disappeared, the photoreceptor cells and choriocapillaris degenerated and finally disappeared. In the eyes injected intravitreally with NaCl solution of equivalent osmosis microvacuoles were seen but no necrotic change in RPE. Thus, a small amount of ornithine damaged RPE selectively, and induced disappearance of the photoreceptors and choriocapillaris secondarily. (J Jpn Ophthalmol Sot lOl:llS-126,1997) Hidemi Maeda, Masamitsu Takeuchi, Kanji Takahashi, Takashi Itagaki, Hiroshi Ohkuma and Masanobu Uyama Department of Ophthalmology, Kansai Medical University
Indocyanine Green Infrared Fluorescence Angiography and Histopathological Correlation in Experimental Choroidal Circulatory Disturbance: Report 2 We performed an experimental study on choroidal circulatory disturbance to clarify basic problems
of Medicine; *Department of Clinical Pathology, Tokai University School of Medicine
Diabetic Keratopathy A variety of cornea1 complications which occur in diabetics were briefly reviewed and the importance of the recognition of diabetic keratopathy was emphasized. This particular disease emerges and persists following the undue stress including intraocular surgery or photocoagulation. A varied degree of epithelial disturbance such as superficial punctate keratopathy, persistent epithelial defect, or recurrent cornea1 erosion can take place based on suppressed cell division, deturgence of barrier function, deterioration of basal cell adhesion, or decreased cornea1 sensitivity. Cornea1 endothelium also exhibits abnormalities in cell morphology including coefficient variation or percentages of hexagonal cells so that cornea1 edema tends to persist postoperatively. The involvement of the polyol pathway has been implicated in the pathogenesis of these disorders. (J Jpn Ophthalmol Sot 101:105-110,1997) Yuichi Ohashi Department of Ophthalmology, Ehime University School of Medicine
Emulsification Experiments with Dimethylsiloxane/Phenylmethylsiloxane Copolymer We compared the emulsification tendency of dimethylsiloxane/phenylmethylsiloxane copolymer (DPC; 5%-phenylated, specific gravity 0.984) with that of silicone oil (dimethylsiloxane; SO, specific gravity 0.966) and fluorosilicone oil (methyl-3,3,3-trifluoropropylsiloxane; FSO, specific gravity 1.256) which are clinically used as an intraocular tamponade. After SO, DPC and FSO were placed in a glass container with an equal amount of albumin solution (1 mg/ml) or y-globulin solution (1 mg/ml), and shaken SO and DPC, with their specific gravities being closer to water, showed less emulsification than FSO. Following vitrectomy, DPC was injected into the rabbit vitreous cavity, but did not seem to show any severe histological damage. Highly-phenylated DPC, which is slightly heavier than water, may be useful to treat inferior retinal detachment in place of FSO. (J Jpn Ophthalmol Sot lOl:lll-117,1997)
Jpn J Ophthalmol Vol41: 339-353.1997
Tsunehiko Ikeda,* Kimitoshi Nakamura,i Kenji Sakagami,* Hiroshi Iwahashi,” Koichi Sugimotojl Takehisa Matsuda,l and Yasuo Tano** *Department of Ophthalmology, Kyoto Prefecture University of Medicine; ?Nakamura Eye Clinic; fDepartment of Ophthalmology, Ehime University Medical School; “Department of Ophthalmology, Osaka Police Hospital; bugimoto Eye Clinic; ‘Department of Bioengineering, National Cardiovascular Center Research Institute; **Department of Ophthalmology, Osaka University Medical School
Ornithine Induced Retinopathy in the Rat: 1. Histopathological Study on the Retinal Pigment Epithelium An intravitreal injection of a small amount of l-ornithine hydrochloride damages the retinal pigment epithelium (RPE) selectively in monkey eyes. In this paper, we examined the rat eye and observed similar results. Clinically, retinal edema appeared immediately after injection and showed hyperfluorescence on a fluorescein angiograph after 3 days. Histopathologically, RPE showed marked swelling 3 hours after injection, then became necrotic and disappeared gradually. One month after injection, retinal structure was maintained in the area where RPE regenerated to cover Bruch’s membrane, but in the area where RPE cells disappeared, the photoreceptor cells and choriocapillaris degenerated and finally disappeared. In the eyes injected intravitreally with NaCl solution of equivalent osmosis microvacuoles were seen but no necrotic change in RPE. Thus, a small amount of ornithine damaged RPE selectively, and induced disappearance of the photoreceptors and choriocapillaris secondarily. (J Jpn Ophthalmol Sot lOl:llS-126,1997) Hidemi Maeda, Masamitsu Takeuchi, Kanji Takahashi, Takashi Itagaki, Hiroshi Ohkuma and Masanobu Uyama Department of Ophthalmology, Kansai Medical University
Indocyanine Green Infrared Fluorescence Angiography and Histopathological Correlation in Experimental Choroidal Circulatory Disturbance: Report 2 We performed an experimental study on choroidal circulatory disturbance to clarify basic problems