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Erratum to “Pharmacogenetics in major depression: a comprehensive meta-analysis.” [Prog Neuropsychopharmacol Biol Psychiatry 45 (2013) 183–194]
Progress in Neuro-Psychopharmacology & Biological Psychiatry 47 (2013) 118–119
Contents lists available at ScienceDirect
Progress in Neuro-Psychopharmacology & Biological Psychiatry journal homepage: www.elsevier.com/locate/pnp
Erratum
Erratum to “Pharmacogenetics in major depression: a comprehensive meta-analysis.” [Prog Neuropsychopharmacol Biol Psychiatry 45 (2013) 183–194] Alessandro Serretti⁎ Department of Biomedical and NeuroMotor Sciences, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy
The publisher regrets that during the publication of the above article some errors occurred in Table 1. The errors have been corrected and the amended Table 1 is reproduced in the following pages.
Table 1 Candidate genes, polymorphisms, and result summary. RefSeq gene symbol
Chromosome position
Varianta
Variant type
MAF
Outcome
Genotype pooling
Meta-analyzed subgroup
No. of studies (cases)
OR
95% CI
P-value
BDNF
11p13
rs6265 [G/A]
SNV
0.23
Response
Val/Met + Met/Met vs Val/Val
Overall
10 (3,301)b
1.23
0.92–1.64
0.16
Val/Met vs Val/Val + Met/Met
9 (3,169)b 8 (1,181)b 7 (2,621)b 7 (796)b 9 (2,821)b 7 (2,375)b 7 (599)b 8 (3,128)b 4 (2,298)b 3 (2,266)b 3 (2,113)b 8 (1,546)
1.26 1.34 1.30 1.53 1.39 1.57 1.74 1.24 1.32 1.33 1.32 1.97
1.07–1.48 1.04–1.74 1.08–1.55 1.12–2.07 1.04–1.85 1.10–2.25 1.16–2.60 1.00–1.53 1.04–1.68 1.04–1.69 1.03–1.70 0.95–4.10
0.006 0.03 0.005 0.007 0.03 0.01 0.007 0.05 0.02 0.02 0.03 0.07
Remission
Val/Met + Met/Met vs Val/Val
Response
Val/Met vs Val/Val + Met/Met Val/Met vs Val/Val L/L vs L/S + S/S
Overall Asians SSRIs Asians, SSRIs Overall SSRIs Asians, SSRIs Overall SSRIs SSRIs SSRIs Overall
6 (1,252) 5 (878) 9 (2,940)b
2.79 4.24 0.91
1.20–6.45 1.32–13.63 0.61–1.34
0.02 0.02 0.63
Val/Met vs Val/Val
SLC6A4
17q11.2
STin2 [12/10/9]
STR
–
HTR1A
5q11.2-q13
rs6295 [C/G]
SNV
0.48
Response
C/C vs C/G + G/G
Asians Asians, SSRIs Overall
HTR2A
13q14-q21
rs6311 [G/A]
SNV
0.44
Remission Response
C/C vs C/G + G/G G/G vs G/A + A/A
Overall Overall
6 (2,322)b 7 (2,295)b
1.14 1.05
0.89–1.45 0.87–1.26
0.30 0.62
G/G + G/A vs A/A G/G vs G/A + A/A C/C + C/T vs T/T
Asians Overall Overall
5 (502)b 4 (2,082)b 8 (3,140)b
1.66 1.26 1.07
1.06–2.60 0.99–1.60 0.84–1.35
0.03 0.06 0.60
HTR6
1p36-p35
rs6313 [C/T]
SNV
0.43
Remission Response
rs7997012 [G/A]
SNV
0.27
Remission Response
C/C vs C/T + T/T G/G vs G/A + A/A
Overall Overall
5 (2,562)b 4 (2,195)b
1.17 0.93
0.95–1.44 0.65–1.35
0.15 0.72
Remission
Response
G/G vs G/A + A/A G/G + G/A vs A/A G/G vs A/A C/C vs C/T + T/T
Overall Non-SSRIs/mixed ADs Non-SSRIs/mixed ADs Overall
6 (2,704)b 3 (696) 3 (344) 4 (2,355)b
1.03 3.19 3.40 1.01
0.77–1.36 1.57–6.46 1.69–6.85 0.79–1.30
0.86 0.001 0.0006 0.94
Remission
C/C vs C/T + T/T
Overall
4 (2,357)b
0.96
0.76–1.22
0.74
rs1805054 [C/T]
SNV
0.17
DOI of original article: http://dx.doi.org/10.1016/j.pnpbp.2013.05.011. ⁎ Tel.: +39 051 6584233; fax: +39 051 521030. E-mail address: [email protected]. 0278-5846/$ – see front matter © 2013 Elsevier Inc. All rights reserved. http://dx.doi.org/10.1016/j.pnpbp.2013.08.006
A. Serretti / Progress in Neuro-Psychopharmacology & Biological Psychiatry 47 (2013) 118–119
119
Table 1 (continued) RefSeq gene symbol
Chromosome position
Varianta
Variant type
MAF
Outcome
Genotype pooling
Meta-analyzed subgroup
No. of studies (cases)
OR
95% CI
P-value
TPH1
11p15.3-p14
rs1800532 [C/A]
SNV
0.36
Response
C/C vs C/A + A/A
Overall
10 (2,814)b
1.29
0.96–1.75
0.09
SLC6A2
16q12.2
SNV
0.27
Remission Response
C/C vs C/A + A/A C/C vs C/T + T/T
Overall Overall
4 (2,310)b 4 (2,608)b
1.02 1.20
0.65–1.60 0.80–1.81
0.93 0.37
COMT
22q11.21
rs5569 [C/T] rs4680 [G/A]
SNV
0.39
Response
G/G vs G/A + A/A
Overall
5 (2,510)b
0.88
0.65–1.19
0.40
GNB3
12p13
rs5443 [C/T]
SNV
0.48
Remission Response
G/G vs G/A + A/A C/C vs C/T + T/T
Overall Overall
5 (2,513)b 8 (1,412)
1.01 0.90
0.80–1.27 0.69–1.18
0.96 0.45
C/C + C/T vs T/T C/C vs C/T + T/T C/C vs C/T + T/T
Overall Asians Overall Overall
7 (1,253) 5 (635) 4 (424) 5 (2,194)
1.37 1.53 0.89 0.88
0.83–2.27 1.05–2.24 0.57–1.40 0.63–1.24
0.22 0.03 0.62 0.47
3 (1,405) 4 (564)b 4 (2,049)
0.70 1.52 0.85
0.52–0.95 1.06–2.17 0.60–1.20
0.02 0.02 0.35
FKBP5
ABCB1 (MDR1)
6p21.31
7q21.12
rs1360780 [C/T]
SNV
0.30
Remission Response
rs3800373 [A/C]
SNV
0.30
Response
A/A vs A/C + C/C
Caucasian Other/mixed ethnicity Overall
rs1045642 [C/T (or A)]
SNV
0.40
Response
C/C vs C/T + T/T
Caucasian Overall
3 (1,390) 5 (2,226)b
0.73 0.93
0.54–0.99 0.72–1.22
0.05 0.62
rs2032582 [G/T (or A)]
SNV
0.34
Remission Response
C/C vs C/T + T/T G/G + G/T vs T/T
Overall Overall
4 (2,134)b 5 (2,112)b
0.70 0.73
0.45–1.07 0.34–1.58
0.10 0.42
Remission
G/G vs T/T G/G vs G/T + T/T
Overall Overall SSRIs SSRIs
4 (1,252)b 3 (2,005)b 3 (1,964)b 3 (1,176)b
0.75 0.75 0.76 0.70
0.58–0.97 0.58–0.97 0.59–0.98 0.49–0.98
0.03 0.03 0.04 0.04
G/G vs T/T
For each included polymorphism the results in the overall sample (all ethnic groups, all antidepressant classes) were reported. Subanalysis results (sample split by ethnic group and/or antidepressant class) were reported only when it was associated with outcome. Other data are available on request. Abbreviations: MAF, minor allele frequency; OR, odds ratio; SNV, single nucleotide variation; STR, short tandem repeat (microsatellite) variation. a Annotated using the dbSNP version 137 [major allele/minor allele]. b The data from STAR*D were included as one study.
Contents lists available at ScienceDirect
Progress in Neuro-Psychopharmacology & Biological Psychiatry journal homepage: www.elsevier.com/locate/pnp
Erratum
Erratum to “Pharmacogenetics in major depression: a comprehensive meta-analysis.” [Prog Neuropsychopharmacol Biol Psychiatry 45 (2013) 183–194] Alessandro Serretti⁎ Department of Biomedical and NeuroMotor Sciences, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy
The publisher regrets that during the publication of the above article some errors occurred in Table 1. The errors have been corrected and the amended Table 1 is reproduced in the following pages.
Table 1 Candidate genes, polymorphisms, and result summary. RefSeq gene symbol
Chromosome position
Varianta
Variant type
MAF
Outcome
Genotype pooling
Meta-analyzed subgroup
No. of studies (cases)
OR
95% CI
P-value
BDNF
11p13
rs6265 [G/A]
SNV
0.23
Response
Val/Met + Met/Met vs Val/Val
Overall
10 (3,301)b
1.23
0.92–1.64
0.16
Val/Met vs Val/Val + Met/Met
9 (3,169)b 8 (1,181)b 7 (2,621)b 7 (796)b 9 (2,821)b 7 (2,375)b 7 (599)b 8 (3,128)b 4 (2,298)b 3 (2,266)b 3 (2,113)b 8 (1,546)
1.26 1.34 1.30 1.53 1.39 1.57 1.74 1.24 1.32 1.33 1.32 1.97
1.07–1.48 1.04–1.74 1.08–1.55 1.12–2.07 1.04–1.85 1.10–2.25 1.16–2.60 1.00–1.53 1.04–1.68 1.04–1.69 1.03–1.70 0.95–4.10
0.006 0.03 0.005 0.007 0.03 0.01 0.007 0.05 0.02 0.02 0.03 0.07
Remission
Val/Met + Met/Met vs Val/Val
Response
Val/Met vs Val/Val + Met/Met Val/Met vs Val/Val L/L vs L/S + S/S
Overall Asians SSRIs Asians, SSRIs Overall SSRIs Asians, SSRIs Overall SSRIs SSRIs SSRIs Overall
6 (1,252) 5 (878) 9 (2,940)b
2.79 4.24 0.91
1.20–6.45 1.32–13.63 0.61–1.34
0.02 0.02 0.63
Val/Met vs Val/Val
SLC6A4
17q11.2
STin2 [12/10/9]
STR
–
HTR1A
5q11.2-q13
rs6295 [C/G]
SNV
0.48
Response
C/C vs C/G + G/G
Asians Asians, SSRIs Overall
HTR2A
13q14-q21
rs6311 [G/A]
SNV
0.44
Remission Response
C/C vs C/G + G/G G/G vs G/A + A/A
Overall Overall
6 (2,322)b 7 (2,295)b
1.14 1.05
0.89–1.45 0.87–1.26
0.30 0.62
G/G + G/A vs A/A G/G vs G/A + A/A C/C + C/T vs T/T
Asians Overall Overall
5 (502)b 4 (2,082)b 8 (3,140)b
1.66 1.26 1.07
1.06–2.60 0.99–1.60 0.84–1.35
0.03 0.06 0.60
HTR6
1p36-p35
rs6313 [C/T]
SNV
0.43
Remission Response
rs7997012 [G/A]
SNV
0.27
Remission Response
C/C vs C/T + T/T G/G vs G/A + A/A
Overall Overall
5 (2,562)b 4 (2,195)b
1.17 0.93
0.95–1.44 0.65–1.35
0.15 0.72
Remission
Response
G/G vs G/A + A/A G/G + G/A vs A/A G/G vs A/A C/C vs C/T + T/T
Overall Non-SSRIs/mixed ADs Non-SSRIs/mixed ADs Overall
6 (2,704)b 3 (696) 3 (344) 4 (2,355)b
1.03 3.19 3.40 1.01
0.77–1.36 1.57–6.46 1.69–6.85 0.79–1.30
0.86 0.001 0.0006 0.94
Remission
C/C vs C/T + T/T
Overall
4 (2,357)b
0.96
0.76–1.22
0.74
rs1805054 [C/T]
SNV
0.17
DOI of original article: http://dx.doi.org/10.1016/j.pnpbp.2013.05.011. ⁎ Tel.: +39 051 6584233; fax: +39 051 521030. E-mail address: [email protected]. 0278-5846/$ – see front matter © 2013 Elsevier Inc. All rights reserved. http://dx.doi.org/10.1016/j.pnpbp.2013.08.006
A. Serretti / Progress in Neuro-Psychopharmacology & Biological Psychiatry 47 (2013) 118–119
119
Table 1 (continued) RefSeq gene symbol
Chromosome position
Varianta
Variant type
MAF
Outcome
Genotype pooling
Meta-analyzed subgroup
No. of studies (cases)
OR
95% CI
P-value
TPH1
11p15.3-p14
rs1800532 [C/A]
SNV
0.36
Response
C/C vs C/A + A/A
Overall
10 (2,814)b
1.29
0.96–1.75
0.09
SLC6A2
16q12.2
SNV
0.27
Remission Response
C/C vs C/A + A/A C/C vs C/T + T/T
Overall Overall
4 (2,310)b 4 (2,608)b
1.02 1.20
0.65–1.60 0.80–1.81
0.93 0.37
COMT
22q11.21
rs5569 [C/T] rs4680 [G/A]
SNV
0.39
Response
G/G vs G/A + A/A
Overall
5 (2,510)b
0.88
0.65–1.19
0.40
GNB3
12p13
rs5443 [C/T]
SNV
0.48
Remission Response
G/G vs G/A + A/A C/C vs C/T + T/T
Overall Overall
5 (2,513)b 8 (1,412)
1.01 0.90
0.80–1.27 0.69–1.18
0.96 0.45
C/C + C/T vs T/T C/C vs C/T + T/T C/C vs C/T + T/T
Overall Asians Overall Overall
7 (1,253) 5 (635) 4 (424) 5 (2,194)
1.37 1.53 0.89 0.88
0.83–2.27 1.05–2.24 0.57–1.40 0.63–1.24
0.22 0.03 0.62 0.47
3 (1,405) 4 (564)b 4 (2,049)
0.70 1.52 0.85
0.52–0.95 1.06–2.17 0.60–1.20
0.02 0.02 0.35
FKBP5
ABCB1 (MDR1)
6p21.31
7q21.12
rs1360780 [C/T]
SNV
0.30
Remission Response
rs3800373 [A/C]
SNV
0.30
Response
A/A vs A/C + C/C
Caucasian Other/mixed ethnicity Overall
rs1045642 [C/T (or A)]
SNV
0.40
Response
C/C vs C/T + T/T
Caucasian Overall
3 (1,390) 5 (2,226)b
0.73 0.93
0.54–0.99 0.72–1.22
0.05 0.62
rs2032582 [G/T (or A)]
SNV
0.34
Remission Response
C/C vs C/T + T/T G/G + G/T vs T/T
Overall Overall
4 (2,134)b 5 (2,112)b
0.70 0.73
0.45–1.07 0.34–1.58
0.10 0.42
Remission
G/G vs T/T G/G vs G/T + T/T
Overall Overall SSRIs SSRIs
4 (1,252)b 3 (2,005)b 3 (1,964)b 3 (1,176)b
0.75 0.75 0.76 0.70
0.58–0.97 0.58–0.97 0.59–0.98 0.49–0.98
0.03 0.03 0.04 0.04
G/G vs T/T
For each included polymorphism the results in the overall sample (all ethnic groups, all antidepressant classes) were reported. Subanalysis results (sample split by ethnic group and/or antidepressant class) were reported only when it was associated with outcome. Other data are available on request. Abbreviations: MAF, minor allele frequency; OR, odds ratio; SNV, single nucleotide variation; STR, short tandem repeat (microsatellite) variation. a Annotated using the dbSNP version 137 [major allele/minor allele]. b The data from STAR*D were included as one study.