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Felix Pinkus: 1868–1947
feLix mnku 1868—i 47
A full life and a distinguished career ended when Professor Felix Pinkus died on November 19, 1947 at Monroe, Michigan. Felix Pinkus was born in Berlin, Germany on April 4, 1868. He graduated from the University of Freiburg, Germany in 1893. From the beginning he was interested in comparative anatomy. He discovered and described the nervus terminalis, a cranial nerve in the fish Protopterus annecteus. This nerve, now usually called nervus pre-olfactorius, later was found to be present in all vertebrae, including man. Felix Pinkus also discovered the hair disk (Haarscheibe), a small nervous organ near the hair. After working in the laboratories of Paul Ehrlich and at the Institute of Robert Koch in Berlin, he became an assistant to Albert Neisser at the Dermatologic
University Clinic in Breslau. His main fields of interest were normal and pathologic anatomy of the skin and especially leukemia of the skin. The former remained his main scientific interest throughout his life. After continued post-
graduate studies with J. Jadassohn in Bern and also at the Hôpital St. Louis in Paris, he practiced dermatology in Berlin from 1898 to 1938. For twentyfive years he was a director of the Hospital for Women of the City of Berlin. He was made Associate Professor of Dermatology and Venereology in 1915. He was prominent in the German National Health Council, where he was especially identified with the prevention and treatment of venereal diseases. In addition to these activities, he published a textbook on skin diseases and
over 150 scientific papers dealing with a great variety of dermatologic and venereologic topics. His most notable contribution was a volume on Normal Anatomy of the Skin in Jadassohn's Handbuch of Skin and Venereal Diseases. He also made many original contributions to dermatology, the best known perhaps being his description of lichen nitidus.
In 1939 he left Germany for Oslo, Norway, and came to the United States in 1941. In the house of his devoted son and daughter-in-law, Hermanu and Hilda Pinkus, in Monroe, Michigan, he found a pleasant and happy new home. Here he continued his histologic studies almost until the very last day of his life. He appreciated greatly the friendly reception he received from his American colleagues. He was made an honorary member of the Society for Investigative
Dermatology and of the Detroit Dermatological Society. More than anything else, he enjoyed the extraordinary hospitality and companionship he found among the dermatologic staff of the University of Minnesota where Doctor Michelson had invited him to lecture on histopathology of the skin. Felix Pinkus was married in 1900 to Elise Etdorf. Two children, a daughter, Luise Grab, and a son, Hermann, survive him. His wife died in 1934. Felix Pinkus was esteemed and loved by everybody who met him—his colleagues, patients, friends. Friends, he had many. His friendship and collabora-
2
TilE JOURNAL OF INVESTIGATIVE DERMATOLOGY
tion with Paul Ehrlich was one of the great experiences of his life. His admiration for Paul Ehrlich's genius was unending. Pinkus was one of the foremost dermatologists and venereologists of Germany; yet he was a very modest man. Although his scientific interests predominated, he was a man with many varied interests. His hobby, beside the study of the
normal anatomy of the skin, was sketching. One could always see him with a pencil and a pad, and when one thought he might take notes or copy a drawing from the board, he would actually be making an interesting sketch of the speaker or of some person in the audience that caught his fancy. Even these sketches showed his natural friendliness toward his fellow men. It is no wonder that Felix Pinkus had endeared himself to those who bad the good fortune to know him in this country.
S. E.
THE JOURNAL OF INVESTIGATIVE DERMATOLOGY
94
linolenic acid extract. Arch. This pdf is a scanned copy UV of irradiated a printed document.
24. Wynn, C. H. and Iqbal, M.: Isolation of rat
skin lysosomes and a comparison with liver Path., 80: 91, 1965. and spleen lysosomes. Biochem. J., 98: lOP, 37. Nicolaides, N.: Lipids, membranes, and the 1966.
human epidermis, p. 511, The Epidermis
Eds., Montagna, W. and Lobitz, W. C. Acascopic localization of acid phosphatase in demic Press, New York. human epidermis. J. Invest. Derm., 46: 431, 38. Wills, E. D. and Wilkinson, A. E.: Release of 1966. enzymes from lysosomes by irradiation and 26. Rowden, C.: Ultrastructural studies of kerathe relation of lipid peroxide formation to tinized epithelia of the mouse. I. Combined enzyme release. Biochem. J., 99: 657, 1966. electron microscope and cytochemical study 39. Lane, N. I. and Novikoff, A. B.: Effects of of lysosomes in mouse epidermis and esoarginine deprivation, ultraviolet radiation and X-radiation on cultured KB cells. J. phageal epithelium. J. Invest. Derm., 49: 181, 25. Olson, R. L. and Nordquist, R. E.: Ultramicro-
No warranty is given about the accuracy of the copy.
Users should refer to the original published dermal cells. Nature, 216: 1031, 1967. version of1965. the material. vest. Derm., 45: 448, 28. Hall, J. H., Smith, J. G., Jr. and Burnett, S. 41. Daniels, F., Jr. and Johnson, B. E.: In prepa1967.
Cell Biol., 27: 603, 1965.
27. Prose, P. H., Sedlis, E. and Bigelow, M.: The 40. Fukuyama, K., Epstein, W. L. and Epstein, demonstration of lysosomes in the diseased J. H.: Effect of ultraviolet light on RNA skin of infants with infantile eczema. J. Inand protein synthesis in differentiated epi-
C.: The lysosome in contact dermatitis: A ration. histochemical study. J. Invest. Derm., 49: 42. Ito, M.: Histochemical investigations of Unna's oxygen and reduction areas by means of 590, 1967. 29. Pearse, A. C. E.: p. 882, Histochemistry Theoultraviolet irradiation, Studies on Melanin, retical and Applied, 2nd ed., Churchill, London, 1960.
30. Pearse, A. C. E.: p. 910, Histacheini.stry Thearetscal and Applied, 2nd ed., Churchill, London, 1960.
31. Daniels, F., Jr., Brophy, D. and Lobitz, W. C.: Histochemical responses of human skin fol-
lowing ultraviolet irradiation. J. Invest. Derm.,37: 351, 1961.
32. Bitensky, L.: The demonstration of lysosomes by the controlled temperature freezing section method. Quart. J. Micr. Sci., 103: 205, 1952.
33. Diengdoh, J. V.: The demonstration of lysosomes in mouse skin. Quart. J. Micr. Sci., 105: 73, 1964.
34. Jarret, A., Spearman, R. I. C. and Hardy, J. A.:
Tohoku, J. Exp. Med., 65: Supplement V, 10, 1957.
43. Bitcnsky, L.: Lysosomes in normal and pathological cells, pp. 362—375, Lysasames Eds., de Reuck, A. V. S. and Cameron, M. Churchill, London, 1953.
44. Janoff, A. and Zweifach, B. W.: Production of inflammatory changes in the microcirculation by cationic proteins extracted from lysosomes. J. Exp. Med., 120: 747, 1964.
45. Herion, J. C., Spitznagel, J. K., Walker, R. I. and Zeya, H. I.: Pyrogenicity of granulocyte lysosomes. Amer. J. Physiol., 211: 693, 1966.
46. Baden, H. P. and Pearlman, C.: The effect of ultraviolet light on protein and nucleic acid synthesis in the epidermis. J. Invest. Derm.,
Histochemistry of keratinization. Brit. J. 43: 71, 1964. Derm., 71: 277, 1959. 35. De Duve, C. and Wattiaux, R.: Functions of 47. Bullough, W. S. and Laurence, E. B.: Mitotic control by internal secretion: the role of lysosomes. Ann. Rev. Physiol., 28: 435, 1966. the chalone-adrenalin complex. Exp. Cell. 36. Waravdekar, V. S., Saclaw, L. D., Jones, W. A. and Kuhns, J. C.: Skin changes induced by
Res., 33: 176, 1964.
A full life and a distinguished career ended when Professor Felix Pinkus died on November 19, 1947 at Monroe, Michigan. Felix Pinkus was born in Berlin, Germany on April 4, 1868. He graduated from the University of Freiburg, Germany in 1893. From the beginning he was interested in comparative anatomy. He discovered and described the nervus terminalis, a cranial nerve in the fish Protopterus annecteus. This nerve, now usually called nervus pre-olfactorius, later was found to be present in all vertebrae, including man. Felix Pinkus also discovered the hair disk (Haarscheibe), a small nervous organ near the hair. After working in the laboratories of Paul Ehrlich and at the Institute of Robert Koch in Berlin, he became an assistant to Albert Neisser at the Dermatologic
University Clinic in Breslau. His main fields of interest were normal and pathologic anatomy of the skin and especially leukemia of the skin. The former remained his main scientific interest throughout his life. After continued post-
graduate studies with J. Jadassohn in Bern and also at the Hôpital St. Louis in Paris, he practiced dermatology in Berlin from 1898 to 1938. For twentyfive years he was a director of the Hospital for Women of the City of Berlin. He was made Associate Professor of Dermatology and Venereology in 1915. He was prominent in the German National Health Council, where he was especially identified with the prevention and treatment of venereal diseases. In addition to these activities, he published a textbook on skin diseases and
over 150 scientific papers dealing with a great variety of dermatologic and venereologic topics. His most notable contribution was a volume on Normal Anatomy of the Skin in Jadassohn's Handbuch of Skin and Venereal Diseases. He also made many original contributions to dermatology, the best known perhaps being his description of lichen nitidus.
In 1939 he left Germany for Oslo, Norway, and came to the United States in 1941. In the house of his devoted son and daughter-in-law, Hermanu and Hilda Pinkus, in Monroe, Michigan, he found a pleasant and happy new home. Here he continued his histologic studies almost until the very last day of his life. He appreciated greatly the friendly reception he received from his American colleagues. He was made an honorary member of the Society for Investigative
Dermatology and of the Detroit Dermatological Society. More than anything else, he enjoyed the extraordinary hospitality and companionship he found among the dermatologic staff of the University of Minnesota where Doctor Michelson had invited him to lecture on histopathology of the skin. Felix Pinkus was married in 1900 to Elise Etdorf. Two children, a daughter, Luise Grab, and a son, Hermann, survive him. His wife died in 1934. Felix Pinkus was esteemed and loved by everybody who met him—his colleagues, patients, friends. Friends, he had many. His friendship and collabora-
2
TilE JOURNAL OF INVESTIGATIVE DERMATOLOGY
tion with Paul Ehrlich was one of the great experiences of his life. His admiration for Paul Ehrlich's genius was unending. Pinkus was one of the foremost dermatologists and venereologists of Germany; yet he was a very modest man. Although his scientific interests predominated, he was a man with many varied interests. His hobby, beside the study of the
normal anatomy of the skin, was sketching. One could always see him with a pencil and a pad, and when one thought he might take notes or copy a drawing from the board, he would actually be making an interesting sketch of the speaker or of some person in the audience that caught his fancy. Even these sketches showed his natural friendliness toward his fellow men. It is no wonder that Felix Pinkus had endeared himself to those who bad the good fortune to know him in this country.
S. E.
THE JOURNAL OF INVESTIGATIVE DERMATOLOGY
94
linolenic acid extract. Arch. This pdf is a scanned copy UV of irradiated a printed document.
24. Wynn, C. H. and Iqbal, M.: Isolation of rat
skin lysosomes and a comparison with liver Path., 80: 91, 1965. and spleen lysosomes. Biochem. J., 98: lOP, 37. Nicolaides, N.: Lipids, membranes, and the 1966.
human epidermis, p. 511, The Epidermis
Eds., Montagna, W. and Lobitz, W. C. Acascopic localization of acid phosphatase in demic Press, New York. human epidermis. J. Invest. Derm., 46: 431, 38. Wills, E. D. and Wilkinson, A. E.: Release of 1966. enzymes from lysosomes by irradiation and 26. Rowden, C.: Ultrastructural studies of kerathe relation of lipid peroxide formation to tinized epithelia of the mouse. I. Combined enzyme release. Biochem. J., 99: 657, 1966. electron microscope and cytochemical study 39. Lane, N. I. and Novikoff, A. B.: Effects of of lysosomes in mouse epidermis and esoarginine deprivation, ultraviolet radiation and X-radiation on cultured KB cells. J. phageal epithelium. J. Invest. Derm., 49: 181, 25. Olson, R. L. and Nordquist, R. E.: Ultramicro-
No warranty is given about the accuracy of the copy.
Users should refer to the original published dermal cells. Nature, 216: 1031, 1967. version of1965. the material. vest. Derm., 45: 448, 28. Hall, J. H., Smith, J. G., Jr. and Burnett, S. 41. Daniels, F., Jr. and Johnson, B. E.: In prepa1967.
Cell Biol., 27: 603, 1965.
27. Prose, P. H., Sedlis, E. and Bigelow, M.: The 40. Fukuyama, K., Epstein, W. L. and Epstein, demonstration of lysosomes in the diseased J. H.: Effect of ultraviolet light on RNA skin of infants with infantile eczema. J. Inand protein synthesis in differentiated epi-
C.: The lysosome in contact dermatitis: A ration. histochemical study. J. Invest. Derm., 49: 42. Ito, M.: Histochemical investigations of Unna's oxygen and reduction areas by means of 590, 1967. 29. Pearse, A. C. E.: p. 882, Histochemistry Theoultraviolet irradiation, Studies on Melanin, retical and Applied, 2nd ed., Churchill, London, 1960.
30. Pearse, A. C. E.: p. 910, Histacheini.stry Thearetscal and Applied, 2nd ed., Churchill, London, 1960.
31. Daniels, F., Jr., Brophy, D. and Lobitz, W. C.: Histochemical responses of human skin fol-
lowing ultraviolet irradiation. J. Invest. Derm.,37: 351, 1961.
32. Bitensky, L.: The demonstration of lysosomes by the controlled temperature freezing section method. Quart. J. Micr. Sci., 103: 205, 1952.
33. Diengdoh, J. V.: The demonstration of lysosomes in mouse skin. Quart. J. Micr. Sci., 105: 73, 1964.
34. Jarret, A., Spearman, R. I. C. and Hardy, J. A.:
Tohoku, J. Exp. Med., 65: Supplement V, 10, 1957.
43. Bitcnsky, L.: Lysosomes in normal and pathological cells, pp. 362—375, Lysasames Eds., de Reuck, A. V. S. and Cameron, M. Churchill, London, 1953.
44. Janoff, A. and Zweifach, B. W.: Production of inflammatory changes in the microcirculation by cationic proteins extracted from lysosomes. J. Exp. Med., 120: 747, 1964.
45. Herion, J. C., Spitznagel, J. K., Walker, R. I. and Zeya, H. I.: Pyrogenicity of granulocyte lysosomes. Amer. J. Physiol., 211: 693, 1966.
46. Baden, H. P. and Pearlman, C.: The effect of ultraviolet light on protein and nucleic acid synthesis in the epidermis. J. Invest. Derm.,
Histochemistry of keratinization. Brit. J. 43: 71, 1964. Derm., 71: 277, 1959. 35. De Duve, C. and Wattiaux, R.: Functions of 47. Bullough, W. S. and Laurence, E. B.: Mitotic control by internal secretion: the role of lysosomes. Ann. Rev. Physiol., 28: 435, 1966. the chalone-adrenalin complex. Exp. Cell. 36. Waravdekar, V. S., Saclaw, L. D., Jones, W. A. and Kuhns, J. C.: Skin changes induced by
Res., 33: 176, 1964.