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Filter plates for high-throughput bioassays
NEWS salt buffer, facilitating downstream applications. The method is quick, suitable for parallel processing and offered in a ready-to-use kit. The kit further improves the resolution and detection of lower abundance sample proteins by electrophoresis, chromatography and mass spectrometry by removing up to 75% of high abundant serum proteins, says Vivascience. The anti-HSA ligand also shows reactivity against rat and mouse albumin. As Protein G is also efficient at binding rat and mouse IgG, this kit can be used for processing samples from the three most frequently encountered sample sources in biomarker research. The Vivapure Anti-HSA/IgG Kit contains Anti-HSA/IgG affinity resin, centrifugal columns (which can be filled individually with the resin), micro-centrifuge tubes, and binding buffer for preparing 12 serum samples. The spin column format allows a single sample to be processed within 20 minutes. The company says that by introducing this kit, it is expanding its range of Vivapure sample preparation products, including the Vivapure Anti-HSA kit for albumin depletion; Vivapure Anti-HSA resin for albumin depletion from serum volumes up to 400 µl; and Vivapure ion-exchange spin columns for sample fractionation. Contact: Vivascience AG, Feodor-Lynen-Strasse 21, D-30625 Hannover, Germany. Tel: +49 511 524 8750, Fax: +49 511 524 87519, www.vivascience.com
Filter plates for high-throughput bioassays Massachusetts-based Millipore Corporation has announced the availability of its 384-well MultiScreenHTS filter plates that are optimized for high throughput bioassays. Available with glass fiber or phospho-cellulose (PH) paper, the filter plates are compatible with automated procedures on a range of robots, without sacrificing sensitivity, robustness or precision. In addition, the plates can be directly scaled up from 96-well filter-based assays.
MultiScreenHTS 384-well plates with glass fiber FB or FC membrane material are ideal for receptor-ligand binding assays, says Millipore. The assays can be performed directly in the filter plates, to conserve reagents and reduce radioactive waste. Also, performing the assay in one plate minimizes manipulations and eliminates the need for separate incubation plates. Designed for coincidence scintillation counting, quantitative data can be collected at very low specific activity levels, and for challenging tritiated (3H) ligands. Compared with most homogeneous assays, the MultiScreenHTSPH 384-well filter plates are easy to set up, says Millipore. The PH paper retains peptide substrates, while the plate design allows rapid washing to remove the unreacted, labelled adenosine tiphosphate. In contrast to non-filter-based methods, the PH paper also allows improved discrimination between the drug target and non-hits. Additionally, the company’s prevalidated MultiScreen protocol eliminates the need to design, develop and optimize various combinations of reagents. The filter plates meet the 2004 American National Standards Institute/Society for Biomolecular Screening (ANSI/SBS) standards for multi-well filter plates. Contact: Millipore Corporation, 290 Concord Road, Billerica, MA 01821, USA. Tel: +1 978 715 4321, Fax: +1 781 533 3110, www.millipore.com
(1.5 to 2.5 bar). It can be sanitized at a temperature of more than 80°C in 30 minutes. Compared with conventional EDI modules, the SMH 3000 uses a hydrodynamic design that permits a higher sanitization flow rate of up to 70% of the ultrapure water output, with a pressure drop of 0.1 MPa (1 bar), says the company. The resulting flow rates ensure a uniform temperature distribution and efficient deactivation of micro-organisms throughout the module. In its normal operating mode, the design also ensures a continuous, turbulent flow that prevents the growth of microbiological organisms. For this reason, only periodic heating phases are necessary. As with all the other modules in the Septron series, the SMH 3000 offers a water conversion efficiency of up to 98% and a voltage drop of not more than 100 V. With conductivity values of less than 0.1 µS/cm, total organic carbon values of less than 50 ppb, and the complete removal of CO 2 and SiO 2 , the generated ultra-pure water easily complies with the requirements of the American and European pharmacopoeia, according to Christ Water Technology. Contact: Christ Water Technology Group, Hauptstrasse 192, PO Box 130, CH-4147 Aesch BL, Switzerland. Tel: +41 61 755 8111, Fax: +41 61 751 4485, www.christwater.com
Akzo Nobel wins New module joins water treatment contract Septron series Swiss company Christ Water Technology Group has supplemented its Septron series of water treatment units with an electro-deionization (EDI) module for high flow rates, which can be sanitized with hot water. As a component part of the company’s Osmotron system, which produces both purified and highly purified water, the SMH 3000 operates at an output of 2500 to 3300 l/h, with a pressure loss of 0.15 to 0.25 MPa
Akzo Nobel’s MPP Systems business has won a contract to supply a water purification unit for one of the world’s most challenging gas field development projects. The contract involves providing the project with a macroporous polymer extraction (MPPE) purification unit to remove dissolved hydrocarbons from its process water. According to the Dutch company, Ormen Lange is the deepest gas field development project on the Norwegian continental shelf.
In Brief Hydranautics increases price of RO products US company Hydranautics has announced a 6% general price increase for all of its reverse osmosis and nanofiltration products. The company says the increase is necessary to partially offset the rise in cost of all components used in its manufactured products. Essentially all of the material used in an RO element is petroleum-based, and a significant rise in the price of oil over the past year has had an effect on the cost of such materials. Starsoft changes its name and trading symbol Starsoft Inc of Burnaby, British Columbia has changed its company name and trading symbol ‘STSF’ on the Over the Counter Bulletin Board (OTCBB). The company is now known as Hendrx Corporation, and its trading symbol is ‘HDRX’. The firm is involved in the research and development, manufacture, marketing and worldwide distribution of devices for the generation, filtration and purification of water. Its products include atmospheric water generation units, alkaline calcium ionic water dispensers, reverse osmosis devices and carbon filters. The decision to change the firm’s name was taken by holders of a majority of the outstanding shares of the company’s common stock by written consent. CHF Solutions appoints vice president of marketing Medical device manufacturer CHF Solutions Inc, which is based in Brooklyn Park, Minnesota, has named Michael Gebauer as its vice president of marketing. In this role, Gebauer will lead and expand the sales and marketing efforts for the Aquadex System 100, a product developed by the company to treat fluidoverloaded patients suffering from congestive heart failure. The system is described as a mechanical pump/ultrafiltration unit, which is designed to remove excess fluid from patients. In heart-failure patients excess fluid causes swollen legs and arms, fatigue and eventually severe and life-threatening shortness of breath.
3 Membrane Technology May 2005
Filter plates for high-throughput bioassays Massachusetts-based Millipore Corporation has announced the availability of its 384-well MultiScreenHTS filter plates that are optimized for high throughput bioassays. Available with glass fiber or phospho-cellulose (PH) paper, the filter plates are compatible with automated procedures on a range of robots, without sacrificing sensitivity, robustness or precision. In addition, the plates can be directly scaled up from 96-well filter-based assays.
MultiScreenHTS 384-well plates with glass fiber FB or FC membrane material are ideal for receptor-ligand binding assays, says Millipore. The assays can be performed directly in the filter plates, to conserve reagents and reduce radioactive waste. Also, performing the assay in one plate minimizes manipulations and eliminates the need for separate incubation plates. Designed for coincidence scintillation counting, quantitative data can be collected at very low specific activity levels, and for challenging tritiated (3H) ligands. Compared with most homogeneous assays, the MultiScreenHTSPH 384-well filter plates are easy to set up, says Millipore. The PH paper retains peptide substrates, while the plate design allows rapid washing to remove the unreacted, labelled adenosine tiphosphate. In contrast to non-filter-based methods, the PH paper also allows improved discrimination between the drug target and non-hits. Additionally, the company’s prevalidated MultiScreen protocol eliminates the need to design, develop and optimize various combinations of reagents. The filter plates meet the 2004 American National Standards Institute/Society for Biomolecular Screening (ANSI/SBS) standards for multi-well filter plates. Contact: Millipore Corporation, 290 Concord Road, Billerica, MA 01821, USA. Tel: +1 978 715 4321, Fax: +1 781 533 3110, www.millipore.com
(1.5 to 2.5 bar). It can be sanitized at a temperature of more than 80°C in 30 minutes. Compared with conventional EDI modules, the SMH 3000 uses a hydrodynamic design that permits a higher sanitization flow rate of up to 70% of the ultrapure water output, with a pressure drop of 0.1 MPa (1 bar), says the company. The resulting flow rates ensure a uniform temperature distribution and efficient deactivation of micro-organisms throughout the module. In its normal operating mode, the design also ensures a continuous, turbulent flow that prevents the growth of microbiological organisms. For this reason, only periodic heating phases are necessary. As with all the other modules in the Septron series, the SMH 3000 offers a water conversion efficiency of up to 98% and a voltage drop of not more than 100 V. With conductivity values of less than 0.1 µS/cm, total organic carbon values of less than 50 ppb, and the complete removal of CO 2 and SiO 2 , the generated ultra-pure water easily complies with the requirements of the American and European pharmacopoeia, according to Christ Water Technology. Contact: Christ Water Technology Group, Hauptstrasse 192, PO Box 130, CH-4147 Aesch BL, Switzerland. Tel: +41 61 755 8111, Fax: +41 61 751 4485, www.christwater.com
Akzo Nobel wins New module joins water treatment contract Septron series Swiss company Christ Water Technology Group has supplemented its Septron series of water treatment units with an electro-deionization (EDI) module for high flow rates, which can be sanitized with hot water. As a component part of the company’s Osmotron system, which produces both purified and highly purified water, the SMH 3000 operates at an output of 2500 to 3300 l/h, with a pressure loss of 0.15 to 0.25 MPa
Akzo Nobel’s MPP Systems business has won a contract to supply a water purification unit for one of the world’s most challenging gas field development projects. The contract involves providing the project with a macroporous polymer extraction (MPPE) purification unit to remove dissolved hydrocarbons from its process water. According to the Dutch company, Ormen Lange is the deepest gas field development project on the Norwegian continental shelf.
In Brief Hydranautics increases price of RO products US company Hydranautics has announced a 6% general price increase for all of its reverse osmosis and nanofiltration products. The company says the increase is necessary to partially offset the rise in cost of all components used in its manufactured products. Essentially all of the material used in an RO element is petroleum-based, and a significant rise in the price of oil over the past year has had an effect on the cost of such materials. Starsoft changes its name and trading symbol Starsoft Inc of Burnaby, British Columbia has changed its company name and trading symbol ‘STSF’ on the Over the Counter Bulletin Board (OTCBB). The company is now known as Hendrx Corporation, and its trading symbol is ‘HDRX’. The firm is involved in the research and development, manufacture, marketing and worldwide distribution of devices for the generation, filtration and purification of water. Its products include atmospheric water generation units, alkaline calcium ionic water dispensers, reverse osmosis devices and carbon filters. The decision to change the firm’s name was taken by holders of a majority of the outstanding shares of the company’s common stock by written consent. CHF Solutions appoints vice president of marketing Medical device manufacturer CHF Solutions Inc, which is based in Brooklyn Park, Minnesota, has named Michael Gebauer as its vice president of marketing. In this role, Gebauer will lead and expand the sales and marketing efforts for the Aquadex System 100, a product developed by the company to treat fluidoverloaded patients suffering from congestive heart failure. The system is described as a mechanical pump/ultrafiltration unit, which is designed to remove excess fluid from patients. In heart-failure patients excess fluid causes swollen legs and arms, fatigue and eventually severe and life-threatening shortness of breath.
3 Membrane Technology May 2005