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Five Year Retrospective Slide Reviews by Screening Method
Abstracts
S35
Pathologists’ agreement rate with cytotechnologist
Table 2
PST76 Five Year Retrospective Slide Reviews by Screening Method Lisa Ring, BS, CT(ASCP) MBCM, Brenda Sweeney, MS, SCT(ASCP), MBCM, Diane Kuebler, BS, CT(ASCP), MB, David Wilbur, MD. Massachusetts General Hospital, Boston, MA Introduction: The FocalPointTM System has been shown to increase screening sensitivity by hierarchical slide and/or field of view stratification. Does this translate into fewer false negative cases? This study uses the 5 year look-back process to test such a hypothesis. Materials and Methods: Available data from 15 years (2000-2015) of HSIL retrospective negative Pap test reviews was analyzed and the method of screening was recorded (after 2010 onlydfollowing guided screening initiation). Results: Available data from 5 year negative review for current HSIL cases revealed 38 discrepancies. Nineteen cases were considered to have been ASCUS, 2 LSIL, 13 ASC-H and 4 HSIL or above on rereview (Table 1). Table 2 highlights the screening methods for cases with discrepancies. From 2010-2015, cases discovered included one field of view and full slide review (FOV/FSR), 8 FSR only, 2 unknown GS and 1 no further review cases. Conclusion: Based on the available data, since the introduction of the FocalPointTM GS the only cases of HSIL+ discovered on retrospective review were cases that had received a full manual screening (FSR) and therefore are not directly attributable to issues of FOV-only reviews. In addition, the number of abnormal cases identified in the 5 year retrospective review has declined steadily since the introduction of automated screening (Figure 1) with no cases of HSIL+ being identified on retrospective review beyond 2010.
Table 1
Figure 1
PST77 LSIL Cervical Cytology Report Rate and Histological Follow-up Finding in China’s Largest CAP-Certified Laboratory Baowen Zheng, MD1, Guijian Wei, BS1, Chengquan Zhao, MD2. 1Kingmed Diagnostics, Guangzhou, China; 2Magee Womens Hospital of UPMC, Pittsburgh, PA Introduction: We studied the age-adjusted low grade squamous intraepithelial lesion (LSIL) report rates and histopathologic follow-up in China’s largest CAP-certified laboratory. Materials and Methods: A retrospective study identified LSIL cervical cytology reports between 2011 and 2015 from the Cytology Laboratory, Guangzhou Kingmed Diagnostics. LSIL cases and histological follow-up results were analyzed. The patients were divided into age groups (10 years). Results: A total 2,206,588 Pap tests were performed in this laboratory in the past five years, including 1513265 (68.6%) four LBC preparations and 693323 (31.4%) conventional Pap tests (CPT). The average age was 38.4 years (1588). LSIL report rate was 1.72% (37895 cases). The LSIL reporting rate in women <30 years was significantly high than that in women (2.1% vs 1.67%). The LBC LSIL rate was 2.1%, which was higher than the CPT LSIL rate of 0.9% (P < 0.001). Among the different LBC methods, the LSIL reporting rates were: SurePath 3.3%, ThinPrep and LITUO 2.0%, LPT 1.5%. Histopathologic diagnoses within 6 months after LSIL were identified in 5987 patients. Overall CIN2/3 was identified in 15.2% patients. HSIL detection rate in Thinprep was significant higher than in SurePath (pZ0.0165), but not others. In generally CIN2/3 detection rates showed no significance between LBCs and CPT. No cervical cancer was found in all follow-up women. Conclusions: This is the largest case study in women with LSIL Pap test and histological follow up results in China. The 85.1% positive predict value of LSIL Pap for follow-up CIN lesions was within currently recognized benchmark ranges for international cytology laboratories. The higher rate of CIN2/3 detection likely reflects the largely unscreened population or some equivocal HSIL cytology cases. Although LSIL reporting rate in lower in CPT than LBC, positive predict value for the CIN lesion was similar among the Pap preparation methods.
S35
Pathologists’ agreement rate with cytotechnologist
Table 2
PST76 Five Year Retrospective Slide Reviews by Screening Method Lisa Ring, BS, CT(ASCP) MBCM, Brenda Sweeney, MS, SCT(ASCP), MBCM, Diane Kuebler, BS, CT(ASCP), MB, David Wilbur, MD. Massachusetts General Hospital, Boston, MA Introduction: The FocalPointTM System has been shown to increase screening sensitivity by hierarchical slide and/or field of view stratification. Does this translate into fewer false negative cases? This study uses the 5 year look-back process to test such a hypothesis. Materials and Methods: Available data from 15 years (2000-2015) of HSIL retrospective negative Pap test reviews was analyzed and the method of screening was recorded (after 2010 onlydfollowing guided screening initiation). Results: Available data from 5 year negative review for current HSIL cases revealed 38 discrepancies. Nineteen cases were considered to have been ASCUS, 2 LSIL, 13 ASC-H and 4 HSIL or above on rereview (Table 1). Table 2 highlights the screening methods for cases with discrepancies. From 2010-2015, cases discovered included one field of view and full slide review (FOV/FSR), 8 FSR only, 2 unknown GS and 1 no further review cases. Conclusion: Based on the available data, since the introduction of the FocalPointTM GS the only cases of HSIL+ discovered on retrospective review were cases that had received a full manual screening (FSR) and therefore are not directly attributable to issues of FOV-only reviews. In addition, the number of abnormal cases identified in the 5 year retrospective review has declined steadily since the introduction of automated screening (Figure 1) with no cases of HSIL+ being identified on retrospective review beyond 2010.
Table 1
Figure 1
PST77 LSIL Cervical Cytology Report Rate and Histological Follow-up Finding in China’s Largest CAP-Certified Laboratory Baowen Zheng, MD1, Guijian Wei, BS1, Chengquan Zhao, MD2. 1Kingmed Diagnostics, Guangzhou, China; 2Magee Womens Hospital of UPMC, Pittsburgh, PA Introduction: We studied the age-adjusted low grade squamous intraepithelial lesion (LSIL) report rates and histopathologic follow-up in China’s largest CAP-certified laboratory. Materials and Methods: A retrospective study identified LSIL cervical cytology reports between 2011 and 2015 from the Cytology Laboratory, Guangzhou Kingmed Diagnostics. LSIL cases and histological follow-up results were analyzed. The patients were divided into age groups (10 years). Results: A total 2,206,588 Pap tests were performed in this laboratory in the past five years, including 1513265 (68.6%) four LBC preparations and 693323 (31.4%) conventional Pap tests (CPT). The average age was 38.4 years (1588). LSIL report rate was 1.72% (37895 cases). The LSIL reporting rate in women <30 years was significantly high than that in women (2.1% vs 1.67%). The LBC LSIL rate was 2.1%, which was higher than the CPT LSIL rate of 0.9% (P < 0.001). Among the different LBC methods, the LSIL reporting rates were: SurePath 3.3%, ThinPrep and LITUO 2.0%, LPT 1.5%. Histopathologic diagnoses within 6 months after LSIL were identified in 5987 patients. Overall CIN2/3 was identified in 15.2% patients. HSIL detection rate in Thinprep was significant higher than in SurePath (pZ0.0165), but not others. In generally CIN2/3 detection rates showed no significance between LBCs and CPT. No cervical cancer was found in all follow-up women. Conclusions: This is the largest case study in women with LSIL Pap test and histological follow up results in China. The 85.1% positive predict value of LSIL Pap for follow-up CIN lesions was within currently recognized benchmark ranges for international cytology laboratories. The higher rate of CIN2/3 detection likely reflects the largely unscreened population or some equivocal HSIL cytology cases. Although LSIL reporting rate in lower in CPT than LBC, positive predict value for the CIN lesion was similar among the Pap preparation methods.