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Fragrance raw materials monographs
Fragrance raw materials monographs CUMINYL
87l
ALCOHOL
Synonyms: p-Isopropylbenzyl alcohol; cuminic alcohol. Structure: C H 3 ' CH(CH3)" C~,H,, • C H 2OH. Description and physical properties: A colourless liquid with a spicy o d o u r (Arctander, 1969).
Occurrence: F o u n d in the oil from fruits of Cuminum cyminum and Carum carL'i L. and also in the oils of Eucalyptus hakeris (esterificd) and French lavender (Fenaroli's Handbook of Flat'or Ingredients, 1971; Gildemeistcr & Hoffman. 1962). Preparation: By reduction of cuminaldehyde (Arctander, 1969). Uses: In public use since the 1950s. Use in fragrances in the USA a m o u n t s to less than 2000 lb/yr. Concentration in final p r o d u c t (%): Usual Maximum
Soap
Detergent
Creams, lotions
Perfume
0.01 0.1
0,001 0-01
0.005 0.03
0"I 5 0'4
Analytical data: Gas c h r o m a t o g r a m , R I F M no. 72-113; infra-red curve, R I F M no. 72-113.
Status Cuminyl alcohol was granted G R A S status by F E M A (1965) and is a p p r o v e d by the F D A for food use (21 C F R 121.1164). Thc Council of Europe (1970) included cuminyl alcohol in the list o f admissible artificial flavouring substances at a level of 15 ppm.
Biological data Acute toxicity. The acute oral LD~o in rats was reported as 1.02g/kg (0-9-1.14g/kg) (Moreno. 1973). The acute dcrmal LDso in rabbits was reported as 2.5 g/kg (0.5-3-0g/kg) (Moreno. 1973). h'ritation. Cuminyl alcohol applied full strength to intact or a b r a d e d rabbit skin for 24 hr under occlusion was moderately irritating (Morcno, 1973). Tested at 4% in petrolatum, it p r o d u c e d no irritation after a 48-hr closed-patch test on h u m a n subjects (Epstein, 1973). Sensiti:ation. A maximization test (Kligman, 1966) was carried out on 24 volunteers. The material was tested at a concentration of 4'),i in petrolatum and produced no sensitization reactions (Epstein. 1973).
References Arctander, S. (1969). Per/umeand Flat'or Chemicals(Aroma Chemicals). Vol. 1, no. 752. S. Arctander. Montclair, New Jersey. Council of Europe (1970). Natural and Artificial Flavouring Substances. Partial Agreement in the Social and Public Health Field. List A(I), Series I, no. 89, p. 53. Strasbourg. Epstcin, W. L. (1973). Rcport to RIFM, I October. Fenaroli's ttandhook of Flat'or ln(4redients(1971).Edited by T. E. Furia and N. Bellanca. p. 471. Chemical Rubber Co., Cleveland, Ohio. Flavoring Extract Manufacturers" Association (1965). Survey of flavoring ingredient usage levels. No. 2933. Fd lt,c.hnol.. Champaiyn 19~2),part 2, 155. Gildemeister, E. u. Hoffman, F. (1962). Die )~therischenOh'. Vol. illb, p. 396. Akademie Verlag, Berlin. Kligman, A. M. (1966). The identification of contact allergens by human assay. III. The maximization test. A procedure for screening and rating contact scnsitizcrs. J. ira,est. Derm.47, 393. Morcno, O. M. (1973). Report to RIFM. 20 September.
87l
ALCOHOL
Synonyms: p-Isopropylbenzyl alcohol; cuminic alcohol. Structure: C H 3 ' CH(CH3)" C~,H,, • C H 2OH. Description and physical properties: A colourless liquid with a spicy o d o u r (Arctander, 1969).
Occurrence: F o u n d in the oil from fruits of Cuminum cyminum and Carum carL'i L. and also in the oils of Eucalyptus hakeris (esterificd) and French lavender (Fenaroli's Handbook of Flat'or Ingredients, 1971; Gildemeistcr & Hoffman. 1962). Preparation: By reduction of cuminaldehyde (Arctander, 1969). Uses: In public use since the 1950s. Use in fragrances in the USA a m o u n t s to less than 2000 lb/yr. Concentration in final p r o d u c t (%): Usual Maximum
Soap
Detergent
Creams, lotions
Perfume
0.01 0.1
0,001 0-01
0.005 0.03
0"I 5 0'4
Analytical data: Gas c h r o m a t o g r a m , R I F M no. 72-113; infra-red curve, R I F M no. 72-113.
Status Cuminyl alcohol was granted G R A S status by F E M A (1965) and is a p p r o v e d by the F D A for food use (21 C F R 121.1164). Thc Council of Europe (1970) included cuminyl alcohol in the list o f admissible artificial flavouring substances at a level of 15 ppm.
Biological data Acute toxicity. The acute oral LD~o in rats was reported as 1.02g/kg (0-9-1.14g/kg) (Moreno. 1973). The acute dcrmal LDso in rabbits was reported as 2.5 g/kg (0.5-3-0g/kg) (Moreno. 1973). h'ritation. Cuminyl alcohol applied full strength to intact or a b r a d e d rabbit skin for 24 hr under occlusion was moderately irritating (Morcno, 1973). Tested at 4% in petrolatum, it p r o d u c e d no irritation after a 48-hr closed-patch test on h u m a n subjects (Epstein, 1973). Sensiti:ation. A maximization test (Kligman, 1966) was carried out on 24 volunteers. The material was tested at a concentration of 4'),i in petrolatum and produced no sensitization reactions (Epstein. 1973).
References Arctander, S. (1969). Per/umeand Flat'or Chemicals(Aroma Chemicals). Vol. 1, no. 752. S. Arctander. Montclair, New Jersey. Council of Europe (1970). Natural and Artificial Flavouring Substances. Partial Agreement in the Social and Public Health Field. List A(I), Series I, no. 89, p. 53. Strasbourg. Epstcin, W. L. (1973). Rcport to RIFM, I October. Fenaroli's ttandhook of Flat'or ln(4redients(1971).Edited by T. E. Furia and N. Bellanca. p. 471. Chemical Rubber Co., Cleveland, Ohio. Flavoring Extract Manufacturers" Association (1965). Survey of flavoring ingredient usage levels. No. 2933. Fd lt,c.hnol.. Champaiyn 19~2),part 2, 155. Gildemeister, E. u. Hoffman, F. (1962). Die )~therischenOh'. Vol. illb, p. 396. Akademie Verlag, Berlin. Kligman, A. M. (1966). The identification of contact allergens by human assay. III. The maximization test. A procedure for screening and rating contact scnsitizcrs. J. ira,est. Derm.47, 393. Morcno, O. M. (1973). Report to RIFM. 20 September.