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Frontiers of Skeletal Biology
FRONTIERS OF SKELETAL BIOLOGY
Eleventh and Valedictory Workshop on Cell Biology of Bone and Cartilage in Health and Disease Davos, Switzerland March 18 (arrival) to 22 (departure), 2006
PROGRAM
18.15–18.30
Recess
18.30–19.30
6 selected short oral presentations
18.30–18.40
Poster number 3 Susan Allison, Australia: «Deletion of hypothalamic neuropeptide Y2-receptors in adult mice protects against continued ovariectomy-induced bone loss»
18.40–18.50
Poster number 4 Paul Baldock, Australia: «Central control of cortical bone homeostasis: Neuropeptide Y exerts a negative effect on cortical bone formation»
18.50–19.00
Poster number 5 Wendy Balemans, Belgium: «A novel LRP5 mutation in a patient with increased bone mass results in reduced DKK1-inhibition»
19.00–19.10
Poster number 8 Estelle Bianchi, Switzerland: «Arrestin-regulated genes in osteoblasts exposed to intermittent or continuous PTH»
19.10–19.20
Poster number 11 Aline Bozec, Austria: «FRA-2 is a novel regulator of bone development affecting osteoclasts, osteoblasts and chondrocytes»
19.20–19.30
Poster number 13 Belen Espina, U.K.: «BIM is a novel regulator of glucocorticoidinduced apoptosis in osteoblasts»
SATURDAY MARCH 18, 2006 15.00–18.30
Registration + Poster mounting
17.00–18.30
Welcome drink
SUNDAY MARCH 19, 2006 Morning 08.30–08.40
Opening of the Workshop H. Fleisch, Switzerland
08.40–09.25
Keynote address Bjorn Olsen, USA: «Lessons learnt from human genetics in 20 years»
09.25–10.10
Keynote address Shigeaki Kato, Japan: «Nuclear receptors and bone»
10.10–10.30
Coffee
10.30–11.15
Keynote address Benoit de Crombrugghe, USA: «Transcriptional controls in osteoblast and chondrocyte differentiation»
11.15–12.30
12.30–16.00
Poster session «Osteoblasts and bone formation» (1st part) Posters 1–21 Free time (Posters can be viewed)
Afternoon Evening 15.30–16.30
Coffee / Tea
16.00–17.00
Poster session «Osteoblasts and bone formation» (2nd part) Posters 22–43
17.00–17.45
Keynote address Peter Bodine, USA: «Wnt signaling in osteoblast differentiation and bone formation»
17.45–18.15
Hot topic Seiji Fukumoto, Japan: «Klotho protein in tissue selective activation of FGF23 receptor»
Fireside discussions (ad hoc organization)
MONDAY MARCH 20, 2006
18.20–18.30
Poster number 28 Deborah J. Mason, U.K.: «Do adenosine and glutamate-mediated signaling pathways interact in osteoblasts and osteocytes?»
18.30–18.40
Poster number 30 Keisuke Nakagawa, Japan: «Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation»
18.40–18.50
Poster number 37 René St-Arnaud, Canada: «Inhibition of FIAT (factor inhibiting ATF4-mediated transcription) by RNA knockdown upregulates osteocalcin transcription in osteoblastic cells»
Morning 08.30–09.15
Keynote address Erwin Wagner, Austria: «Transcriptional control of the osteoclast»
09.15–10.00
Keynote address Gerard Karsenty, USA: «Central control of bone».
10.00–10.30
Coffee
10.30–11.00
Hot Topic Andrew Karaplis, Canada: «Mouse genetic evidence for paracrine role of PTHrP in bone»
11.00–11.30
Hot Topic Paul Frenette, USA: «Sympathetic control of hemopoiesis in stem cell compartment in marrow»
18.50–19.00
Poster number 39 Itaru Urakawa, Japan: «Klotho is an essential molecule responsible for tissue specific FGF23 signaling»
11.30–12.30
Poster session «Osteoclasts and bone resorption» Posters 44–66
19.00–19.10
12.30–16.00
Free time (Posters can be viewed)
Poster number 51 Dominique Heymann, France: «Characterization of osteoprotegerin binding to glycosaminoglycans by surface plasmon resonance: Role in the interactions with receptor activator of nuclear factor KB ligand (RANKL) and RANK»
19.10–19.20
Poster number 52 Dominique Heymann, France: «Non-viral osteoprotegerin gene transfer inhibits the tumor progression and prolongs survival in a mouse experimental model of osteosarcoma»
19.20–19.30
Poster number 53 Willy Hofstetter, Switzerland: «The effects of tumor necrosis factor 움 on osteoclast formation depends on the haematopoietic precursors»
Afternoon 15.30–16.30
Coffee / Tea
16.00–17.00
Poster session «Osteoclasts and bone resorption» Posters 44–66
17.00–17.45
Keynote address Lawrence Riggs, USA: «Impact on clinical medicine of discovery of osteoclast growth factors»
17.45–18.00
Recess
18.00–19.30
9 selected short oral presentations
Evening
18.00–18.10
Poster number 19 Yasuo Imanishi, Japan: «Elevated expression of FGF23 in bone in an in vivo murine model of primary hyperparathyroidism»
Fireside discussions (ad hoc organization)
18.10–18.20
Poster number 23 Rachel Locklin, U.K.: «Selective targeting of DR5 circumvents resistance of MG-63 osteosarcoma to trailinduced apoptosis»
TUESDAY MARCH 21, 2006
Afternoon
Morning
15.30–16.30
Coffee / Tea
Keynote address Henry Kronenberg, USA: «PTH/PTHrP in bone development and in maturity»
16.00–17.00
Poster session Posters 1–77
09.15–10.00
Keynote address Roger Bouillon, Belgium: «Vitamin D and the skeleton»
17.00–17.30
10.00–10.30
Coffee
Hot Topic Rutger L. van Bezooijen, The Netherlands: «Sclerostin’s mechanism of inhibiting bone formation»
10.30–11.30
6 selected short oral presentations
17.30–18.00
10.30–10.40
Poster number 54 Shintaro Koga, Japan: «Association of C-SRC and adhesion and degranulation-promoting adaptor protein (ADAP) in osteoclastogenesis in vitro»
Hot Topic Hansjörg Keller, Switzerland: «Hormone regulation of SOST gene»
18.00–18.30
Hot Topic Chris Paszty, USA: «Anti-SOST as an anabolic therapy for bone»
18.30–18.45
Recess
18.45–19.45
Valedictory lecture Jack Martin, Australia: «Bone cell biology; two decades providing for the future» In honour of Dr. Gideon Rodan
19.45
Herbert Fleisch, Switzerland: Closure of the workshop
From 22.00
After Dinner Farewell Party
08.30–09.15
10.40–10.50
10.50–11.00
Poster number 58 Takashi Nakamura, Japan: «Functional analysis of HB-EGF during osteoclastogenesis» Poster number 59 Kazuya Oshima, Japan: «Adiponectin increases bone mass by suppressing osteoclasts and activating osteoblasts»
11.00–11.10
Poster number 61 Natalie Sims, Australia: «Cardiotrophin-1 regulates osteoclast and osteoblast function in a manner distinct from other gp130 cytokines»
11.10–11.20
Poster number 64 Keith Thompson, U.K.: «Alkaylamines prevent osteoclast formation and activity by inhibiting the mevalonate pathway»
11.20–11.30
Poster number 74 Junko Murai, Japan: «Identification of a CTCF-binding site between the RXRB and the COL11A2 genes, and its functions»
11.30–12.30
Poster session «Cartilage cells and other cells» Posters 67–77
12.30–16.00
Free time (Posters can be viewed)
Special Session on Sclerostin:
FOR FURTHER INFORMATION, PLEASE CONTACT Heidi Triet Office Prof. H. Fleisch Effingerstrasse 40 CH-3008 Bern Switzerland Tel.: +41 31 389 92 76 Fax: +41 31 389 92 84 e-mail: secretariat@hfleisch.ch or see on http://www.ibmsonline.org/cellbiology.htm
Eleventh and Valedictory Workshop on Cell Biology of Bone and Cartilage in Health and Disease Davos, Switzerland March 18 (arrival) to 22 (departure), 2006
PROGRAM
18.15–18.30
Recess
18.30–19.30
6 selected short oral presentations
18.30–18.40
Poster number 3 Susan Allison, Australia: «Deletion of hypothalamic neuropeptide Y2-receptors in adult mice protects against continued ovariectomy-induced bone loss»
18.40–18.50
Poster number 4 Paul Baldock, Australia: «Central control of cortical bone homeostasis: Neuropeptide Y exerts a negative effect on cortical bone formation»
18.50–19.00
Poster number 5 Wendy Balemans, Belgium: «A novel LRP5 mutation in a patient with increased bone mass results in reduced DKK1-inhibition»
19.00–19.10
Poster number 8 Estelle Bianchi, Switzerland: «Arrestin-regulated genes in osteoblasts exposed to intermittent or continuous PTH»
19.10–19.20
Poster number 11 Aline Bozec, Austria: «FRA-2 is a novel regulator of bone development affecting osteoclasts, osteoblasts and chondrocytes»
19.20–19.30
Poster number 13 Belen Espina, U.K.: «BIM is a novel regulator of glucocorticoidinduced apoptosis in osteoblasts»
SATURDAY MARCH 18, 2006 15.00–18.30
Registration + Poster mounting
17.00–18.30
Welcome drink
SUNDAY MARCH 19, 2006 Morning 08.30–08.40
Opening of the Workshop H. Fleisch, Switzerland
08.40–09.25
Keynote address Bjorn Olsen, USA: «Lessons learnt from human genetics in 20 years»
09.25–10.10
Keynote address Shigeaki Kato, Japan: «Nuclear receptors and bone»
10.10–10.30
Coffee
10.30–11.15
Keynote address Benoit de Crombrugghe, USA: «Transcriptional controls in osteoblast and chondrocyte differentiation»
11.15–12.30
12.30–16.00
Poster session «Osteoblasts and bone formation» (1st part) Posters 1–21 Free time (Posters can be viewed)
Afternoon Evening 15.30–16.30
Coffee / Tea
16.00–17.00
Poster session «Osteoblasts and bone formation» (2nd part) Posters 22–43
17.00–17.45
Keynote address Peter Bodine, USA: «Wnt signaling in osteoblast differentiation and bone formation»
17.45–18.15
Hot topic Seiji Fukumoto, Japan: «Klotho protein in tissue selective activation of FGF23 receptor»
Fireside discussions (ad hoc organization)
MONDAY MARCH 20, 2006
18.20–18.30
Poster number 28 Deborah J. Mason, U.K.: «Do adenosine and glutamate-mediated signaling pathways interact in osteoblasts and osteocytes?»
18.30–18.40
Poster number 30 Keisuke Nakagawa, Japan: «Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation»
18.40–18.50
Poster number 37 René St-Arnaud, Canada: «Inhibition of FIAT (factor inhibiting ATF4-mediated transcription) by RNA knockdown upregulates osteocalcin transcription in osteoblastic cells»
Morning 08.30–09.15
Keynote address Erwin Wagner, Austria: «Transcriptional control of the osteoclast»
09.15–10.00
Keynote address Gerard Karsenty, USA: «Central control of bone».
10.00–10.30
Coffee
10.30–11.00
Hot Topic Andrew Karaplis, Canada: «Mouse genetic evidence for paracrine role of PTHrP in bone»
11.00–11.30
Hot Topic Paul Frenette, USA: «Sympathetic control of hemopoiesis in stem cell compartment in marrow»
18.50–19.00
Poster number 39 Itaru Urakawa, Japan: «Klotho is an essential molecule responsible for tissue specific FGF23 signaling»
11.30–12.30
Poster session «Osteoclasts and bone resorption» Posters 44–66
19.00–19.10
12.30–16.00
Free time (Posters can be viewed)
Poster number 51 Dominique Heymann, France: «Characterization of osteoprotegerin binding to glycosaminoglycans by surface plasmon resonance: Role in the interactions with receptor activator of nuclear factor KB ligand (RANKL) and RANK»
19.10–19.20
Poster number 52 Dominique Heymann, France: «Non-viral osteoprotegerin gene transfer inhibits the tumor progression and prolongs survival in a mouse experimental model of osteosarcoma»
19.20–19.30
Poster number 53 Willy Hofstetter, Switzerland: «The effects of tumor necrosis factor 움 on osteoclast formation depends on the haematopoietic precursors»
Afternoon 15.30–16.30
Coffee / Tea
16.00–17.00
Poster session «Osteoclasts and bone resorption» Posters 44–66
17.00–17.45
Keynote address Lawrence Riggs, USA: «Impact on clinical medicine of discovery of osteoclast growth factors»
17.45–18.00
Recess
18.00–19.30
9 selected short oral presentations
Evening
18.00–18.10
Poster number 19 Yasuo Imanishi, Japan: «Elevated expression of FGF23 in bone in an in vivo murine model of primary hyperparathyroidism»
Fireside discussions (ad hoc organization)
18.10–18.20
Poster number 23 Rachel Locklin, U.K.: «Selective targeting of DR5 circumvents resistance of MG-63 osteosarcoma to trailinduced apoptosis»
TUESDAY MARCH 21, 2006
Afternoon
Morning
15.30–16.30
Coffee / Tea
Keynote address Henry Kronenberg, USA: «PTH/PTHrP in bone development and in maturity»
16.00–17.00
Poster session Posters 1–77
09.15–10.00
Keynote address Roger Bouillon, Belgium: «Vitamin D and the skeleton»
17.00–17.30
10.00–10.30
Coffee
Hot Topic Rutger L. van Bezooijen, The Netherlands: «Sclerostin’s mechanism of inhibiting bone formation»
10.30–11.30
6 selected short oral presentations
17.30–18.00
10.30–10.40
Poster number 54 Shintaro Koga, Japan: «Association of C-SRC and adhesion and degranulation-promoting adaptor protein (ADAP) in osteoclastogenesis in vitro»
Hot Topic Hansjörg Keller, Switzerland: «Hormone regulation of SOST gene»
18.00–18.30
Hot Topic Chris Paszty, USA: «Anti-SOST as an anabolic therapy for bone»
18.30–18.45
Recess
18.45–19.45
Valedictory lecture Jack Martin, Australia: «Bone cell biology; two decades providing for the future» In honour of Dr. Gideon Rodan
19.45
Herbert Fleisch, Switzerland: Closure of the workshop
From 22.00
After Dinner Farewell Party
08.30–09.15
10.40–10.50
10.50–11.00
Poster number 58 Takashi Nakamura, Japan: «Functional analysis of HB-EGF during osteoclastogenesis» Poster number 59 Kazuya Oshima, Japan: «Adiponectin increases bone mass by suppressing osteoclasts and activating osteoblasts»
11.00–11.10
Poster number 61 Natalie Sims, Australia: «Cardiotrophin-1 regulates osteoclast and osteoblast function in a manner distinct from other gp130 cytokines»
11.10–11.20
Poster number 64 Keith Thompson, U.K.: «Alkaylamines prevent osteoclast formation and activity by inhibiting the mevalonate pathway»
11.20–11.30
Poster number 74 Junko Murai, Japan: «Identification of a CTCF-binding site between the RXRB and the COL11A2 genes, and its functions»
11.30–12.30
Poster session «Cartilage cells and other cells» Posters 67–77
12.30–16.00
Free time (Posters can be viewed)
Special Session on Sclerostin:
FOR FURTHER INFORMATION, PLEASE CONTACT Heidi Triet Office Prof. H. Fleisch Effingerstrasse 40 CH-3008 Bern Switzerland Tel.: +41 31 389 92 76 Fax: +41 31 389 92 84 e-mail: secretariat@hfleisch.ch or see on http://www.ibmsonline.org/cellbiology.htm