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Guillain-Barre syndrome associated with Hodgkin’s lymphoma: A case report
Abstracts / Journal of the Neurological Sciences 405S (2019) 116542
97
DEDICATION for moral-scientific support (2019-1980): Africa: N.Mahfouz*/Egypt, W.Soyinka*/Nigeria, Bishop D.Tutu*/South-Africa, Australia: Sir J.Eccles*, Austria: K.Lorenz*, E.Busek, France: J.Dausset*, J.-M.Lehn*, Germany: M.Eigen*, K.v.Klitzing*, E.Neher*, H.Michel*, B.Vogel, W.Scheel, J. &Th.v.Uexküll, GB: A.Hewish*, B.Josephson*, Sir J.Kendrew*, Lord A.Todd*, N.Tinbergen*, India-USA: J.Deisenhofer*, D.Hubel*, H.G.Khorana*, L.Pauling*, K.Singh, Japan-USA: K.Fukui*, Y.Ikemi, S.Tonegawa*, Norway: D. Föllesdal, L.-R.Langslet, Pakistan: A.Salam*, Russia: N.Basov*, A.Prokhorov*, A.Sacharow*, Sweden: S.Bergström*, B.Samuelson* (*Nobel Laureate).
WCN19-1107
doi:10.1016/j.jns.2019.10.952
J.P. Duran Ayllóna, J.A. Gutiérrez Baqueroa, M.A. Silva Solerb, E. Palacios Sanchezb a San José Hospital – Bogotá- Colombia, Neurology, Bogota, Colombia b San José Hospital – Bogotá- Colombia, Neurology, Bogota, Colombia
WCN19-1098 Journal of the Neurological Sciences 405S (2019) 104615 Poster Session 2 Guillain-Barre syndrome associated with Hodgkin’s lymphoma: A case report K. Gowthamana, S. Kandaswamyb a Kumaran Medical Center, Neurology, Coimbatore, India b SRM Medical College Hospital and Research Center, Pathology, Kanchipuram, India Introduction Guillain-Barre syndrome or acute inflammatory demyelinating polyneuropathy has been described in association with different malignant lymphomas, particularly with Hodgkin’s lymphoma. Guillain-Barre syndrome causes muscle weakness and paresthesias which interferes in treatment and can affects the prognosis of patients with underlying lymphoma. We report here a case of Guillain-Barre syndrome in a patient with Hodgkin's lymphoma. Case presentation A 27-year-old man with a diagnosis of stage IIIA relapsed refractory Hodgkin’s lymphoma presented with asymmetrical flaccid arefelxic paraparesis, one month after the end of the third course of chemotherapy. He had been treated 3 years previously for Hodgkin's lymphoma. The clinical course and neurological examination were consistent with Guillain-Barre syndrome. Cerebrospinal fluid studies revealed markedly elevated protein. Nerve conduction studies demonstrated demyelinating motor polyneuropathy with conduction block. Magnetic resonance imaging did not show evidence of metastasis or spinal cord compression. Following intravenous immunoglobulin administration, the neurological symptoms were significantly reduced after one month and subsequently treated with chemotherapy for his lymphoma. Conclusion This case report highlights the importance of considering GBS in the background of Hodgkin’s lymphoma. Guillain-Barre syndrome can make the treatment of patients with lymphoma more difficult and can interfere with delivering full-dose conventional chemotherapy. However, the patient will require follow-up examinations. Keywords: Guillain-Barre syndrome, Hodgkin's lymphoma, Intravenous immunoglobulin doi:10.1016/j.jns.2019.10.953
Journal of the Neurological Sciences 405S (2019) 104616 Poster Session 2 Rapidly progressive dementia secondary to meningeal infiltration by mantle cell lymphoma
Mantle cell lymphoma is part of the Non-Hodgkin lymphomas in which its main characteristics have been described at the level of the lymphoid nodes, spleen, blood and spinal cord. The involvement of the central nervous system is rare and occurs in the late stages of the disease, with a poor short-term prognosis. The most frequent clinical presentations of central nervous system involvement are manifestations related to elevated intracranial pressure and meningeal infiltration. We present a 61-year-old man with a history of mantle cell lymphoma with initial cervical nodular involvement; at the time with a history of 8 months consisting of tremor of low asymmetric amplitude in the upper limbs associated with a clinical progression in the last 3 months given by temporo-spatial disorientation and multi-domain cognitive compromise. It is possible to identify in the first instance a lepomeningeal compromise associated parenchymal involvement, which is why it is considered to expand the study in cerebrospinal fluid evidencing lymphocytic pleocytosis not suggestive of infectious processes with subsequent flow cytometry that recognizes blastoid histology, confirming the central nervous system's involvement. The involvement of the central nervous system secondary to mantle cell lymphoma cells is a rare complication and with poor short-term prognosis, this can be explained by subtle changes in the neurological symptoms of patients. The fact that it has been reported in the late course of the disease makes us think that these patients
97
DEDICATION for moral-scientific support (2019-1980): Africa: N.Mahfouz*/Egypt, W.Soyinka*/Nigeria, Bishop D.Tutu*/South-Africa, Australia: Sir J.Eccles*, Austria: K.Lorenz*, E.Busek, France: J.Dausset*, J.-M.Lehn*, Germany: M.Eigen*, K.v.Klitzing*, E.Neher*, H.Michel*, B.Vogel, W.Scheel, J. &Th.v.Uexküll, GB: A.Hewish*, B.Josephson*, Sir J.Kendrew*, Lord A.Todd*, N.Tinbergen*, India-USA: J.Deisenhofer*, D.Hubel*, H.G.Khorana*, L.Pauling*, K.Singh, Japan-USA: K.Fukui*, Y.Ikemi, S.Tonegawa*, Norway: D. Föllesdal, L.-R.Langslet, Pakistan: A.Salam*, Russia: N.Basov*, A.Prokhorov*, A.Sacharow*, Sweden: S.Bergström*, B.Samuelson* (*Nobel Laureate).
WCN19-1107
doi:10.1016/j.jns.2019.10.952
J.P. Duran Ayllóna, J.A. Gutiérrez Baqueroa, M.A. Silva Solerb, E. Palacios Sanchezb a San José Hospital – Bogotá- Colombia, Neurology, Bogota, Colombia b San José Hospital – Bogotá- Colombia, Neurology, Bogota, Colombia
WCN19-1098 Journal of the Neurological Sciences 405S (2019) 104615 Poster Session 2 Guillain-Barre syndrome associated with Hodgkin’s lymphoma: A case report K. Gowthamana, S. Kandaswamyb a Kumaran Medical Center, Neurology, Coimbatore, India b SRM Medical College Hospital and Research Center, Pathology, Kanchipuram, India Introduction Guillain-Barre syndrome or acute inflammatory demyelinating polyneuropathy has been described in association with different malignant lymphomas, particularly with Hodgkin’s lymphoma. Guillain-Barre syndrome causes muscle weakness and paresthesias which interferes in treatment and can affects the prognosis of patients with underlying lymphoma. We report here a case of Guillain-Barre syndrome in a patient with Hodgkin's lymphoma. Case presentation A 27-year-old man with a diagnosis of stage IIIA relapsed refractory Hodgkin’s lymphoma presented with asymmetrical flaccid arefelxic paraparesis, one month after the end of the third course of chemotherapy. He had been treated 3 years previously for Hodgkin's lymphoma. The clinical course and neurological examination were consistent with Guillain-Barre syndrome. Cerebrospinal fluid studies revealed markedly elevated protein. Nerve conduction studies demonstrated demyelinating motor polyneuropathy with conduction block. Magnetic resonance imaging did not show evidence of metastasis or spinal cord compression. Following intravenous immunoglobulin administration, the neurological symptoms were significantly reduced after one month and subsequently treated with chemotherapy for his lymphoma. Conclusion This case report highlights the importance of considering GBS in the background of Hodgkin’s lymphoma. Guillain-Barre syndrome can make the treatment of patients with lymphoma more difficult and can interfere with delivering full-dose conventional chemotherapy. However, the patient will require follow-up examinations. Keywords: Guillain-Barre syndrome, Hodgkin's lymphoma, Intravenous immunoglobulin doi:10.1016/j.jns.2019.10.953
Journal of the Neurological Sciences 405S (2019) 104616 Poster Session 2 Rapidly progressive dementia secondary to meningeal infiltration by mantle cell lymphoma
Mantle cell lymphoma is part of the Non-Hodgkin lymphomas in which its main characteristics have been described at the level of the lymphoid nodes, spleen, blood and spinal cord. The involvement of the central nervous system is rare and occurs in the late stages of the disease, with a poor short-term prognosis. The most frequent clinical presentations of central nervous system involvement are manifestations related to elevated intracranial pressure and meningeal infiltration. We present a 61-year-old man with a history of mantle cell lymphoma with initial cervical nodular involvement; at the time with a history of 8 months consisting of tremor of low asymmetric amplitude in the upper limbs associated with a clinical progression in the last 3 months given by temporo-spatial disorientation and multi-domain cognitive compromise. It is possible to identify in the first instance a lepomeningeal compromise associated parenchymal involvement, which is why it is considered to expand the study in cerebrospinal fluid evidencing lymphocytic pleocytosis not suggestive of infectious processes with subsequent flow cytometry that recognizes blastoid histology, confirming the central nervous system's involvement. The involvement of the central nervous system secondary to mantle cell lymphoma cells is a rare complication and with poor short-term prognosis, this can be explained by subtle changes in the neurological symptoms of patients. The fact that it has been reported in the late course of the disease makes us think that these patients