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Hematocrit and hypertension incidence: the Gubbio study
AIR 1996; 9:16A-17A
ORALS: Homocysteine and Nutritional Factors
Friday, May 17, 11:20 am
Friday, May 17, 11:35 am
A Randomized Control Trial of the Effects of a Comprehensive Risk Reduction Nutrition Program on Plasma Homocysteine Levels in HypeMensives with Associated Cardiovascular Risk Factors. A Chait, R Malinow, L Resnick·, S Oparil, D Nevin, DA McCarron· on behalf of the Vanguard Study Group. University of Washington, Wayne State University, University of Alabama at Birmingham, and Oregon Health Sciences University, Portland, OR Increased plasma homocysteine (HCY) is a risk factor for atherosclerotic cardiovascular disease. This association is amplified where hypeMension (HTN) or hyperlipidemia (HLP) coexist. The impact of increasing dietary folate, B.., and B. on HCY and the possible interaction of disease conditions in subjects at risk is I10t known. In 343 subjects with HTN, HLP, and/or NIDDM, we evaluated the sbort-term (10 wk) impact on Hey of two dietary regimens: A) a commercially prepared risk reduction nutrition program which provides all the recommended dietary allowances of all nutrients (folate 400 mcg/d, n-171), or B) a nutritionist-guided self-prepared diet meeting the macronutrient goals of a AHH step 1111 diet (n= 172). Plasma HCY (mean±SD) for subjects receiving diet A:
FAMILY HISTORY OF HYPERTENSION-ALTERED SUSCEPTIBILITY OF LDL TO IN VITRO OXIDATION C.~ R. Locher, P. Suter, and W. Vetter. Medical Policlinic, University Hospital ZUrich, Switzerland
N
HTN
43
HTN + NIDDM
8
HTN + HLP
87
HTN + HLP + NIDDM
33
Wk 0 II.4±S.7 1O.6± 11.2 !0.8H.! I I.0±4.S Wk 10 1O.0±S.9 9.3±7.1 9.8±4.6 1I.6±8.S Across HTN diagnostic groups the risk reduction diet (A) significantly (p < .00S) lowered HCY compared to the selfselected diet (B). Subjects with all 3 risk factors though failed to demonstrate a benefit. The presence of more than one cardiovascular risk factor in HTN subjects is associated with 110 reduction in HCY when folate, BI2 , and B. intake is increased. Key Words:
Oxidative mod~ication of Iow-densny lipoprotein (LOLl Increases Is atherogenic potential to Induce the accumulation 01 lipids and cells In the vascular wa•. In order to study an association between hypertension and the susceptibility of LDL oxidation, 8 normotensive patients wnhout family history of hypertension (NT), S normotensive patients wnh family history of hypertension (NT-FHI, 6 hypertensive patients with (HT-FH) and S wnhout family history of hypertension (HT) were evaluated. LOL was oxidatively modnied by Incubation with copper Ions (1.611M1. The course 01 LDL-oxidation was measured In vnro by continuous photometric rnonnoring of the diene formation through an Increase In absorption at wavelenght 234 nm at 37"C.
Compared to NT. a shorter lag-phase (antioxidative capacny) In normotensive patlSnts wnh family history was observed: NT 107±10 min vs NTIFH 87.S±11 min, p
blood pressure, homocysteine, hyperlipidemia, NIDDM
Friday, May 17, 11:50 am
Friday, May 17, 12:05 pm
RELATIONSI;lIP BETWEEN SERUM MICRONUTRIENTS AND BLOOD PRESSURE IN SOUTHWESTERN CHINESE MEN. He J, Klag MJ', Whelton PK·. Johns Hopkins Medical Institutions, Baltimore, MD
HEMATOCRIT AND HYPERTENSION INCIDENCE: TIlE GUBBIO STUDY M....QciJ.1l1•• M Laurenzi, W Panarelli, R Stamler. and J Stamler. Cbair of Nephrology, SUN. Naples. Italy; Dept. of Preventive Medicine. Northwestern Univ. Medical School, Chicago (lL), USA; Merck Sharp &. Dohme, Italy; Gubbio Hospital, Italy High hematoerit is cross-sectionally associated with hypenension. Aim of the study is to investigate this relationship prospectively. Data collected in the Gubbio Population Study at baseline and 6-year follow-up were analyzed. The cohort is 1.670 persons seen at both visits. IlOn-hypenensive at baseline, with hematocrit (HTC) measurement, and baseline ages 18-74 years. At both visits, hypertension was defined as SBP ~ 140 mm Hg, or DBP ~ 90 mm Hg, or antihypertensive treatment. Baseline and follow-up HTC were positively related (r-0.630 in men, r=0.S3O in women. p
To study the reletionship of serum celcium (Ca), magnesium (Mgl, Zinc (Znl end Copper (Cu) to systolic (SBP) and diastolic (DBPI blood pressure, we conducted e cross-sectionel study in community semples of e remote unacculturated population (521 Yi fermers) and 701 urban reSidents from southwestern Chine. Serum Ca, Mg, Zn, and Cu were measured after a 14-hour fastlOg. Blood pressure and dietary nutrient intake were measured on three consecutive deys. Multiple hnear regression enelysis was used to adjust for ege, body mass index, alcohol consumption and sodium lOtake. T~ mean SBP was 103.5 and 113.6 and mean DBP was 64.3 and 71.6 mm Hg lO fermers end urban residents, respectively. The meen level of serum micronutrlents and their partial regression coefficients on BP were as follows: Urban Residents Yi Farmers Mall s.ae o.ae Mall s.ae o.ae 8.85 1.12'" 8.06 1.28'" 0.70'" Ca, mg/dl 2.23 Mg, mg/dl 2.46 -3.83'" -1.89" 113.1 0.04' Zn. pgldl 118.2 0.06'" 106.3 Cu, pg/dl 113.0 • P<0.05; .. P
Key Words:
blood pressure, calcium. magnesium, zinc, copper
Key Words:
Hematoerit. hypertension, incidence, Gubbio study
ORALS: Homocysteine and Nutritional Factors
Friday, May 17, 11:20 am
Friday, May 17, 11:35 am
A Randomized Control Trial of the Effects of a Comprehensive Risk Reduction Nutrition Program on Plasma Homocysteine Levels in HypeMensives with Associated Cardiovascular Risk Factors. A Chait, R Malinow, L Resnick·, S Oparil, D Nevin, DA McCarron· on behalf of the Vanguard Study Group. University of Washington, Wayne State University, University of Alabama at Birmingham, and Oregon Health Sciences University, Portland, OR Increased plasma homocysteine (HCY) is a risk factor for atherosclerotic cardiovascular disease. This association is amplified where hypeMension (HTN) or hyperlipidemia (HLP) coexist. The impact of increasing dietary folate, B.., and B. on HCY and the possible interaction of disease conditions in subjects at risk is I10t known. In 343 subjects with HTN, HLP, and/or NIDDM, we evaluated the sbort-term (10 wk) impact on Hey of two dietary regimens: A) a commercially prepared risk reduction nutrition program which provides all the recommended dietary allowances of all nutrients (folate 400 mcg/d, n-171), or B) a nutritionist-guided self-prepared diet meeting the macronutrient goals of a AHH step 1111 diet (n= 172). Plasma HCY (mean±SD) for subjects receiving diet A:
FAMILY HISTORY OF HYPERTENSION-ALTERED SUSCEPTIBILITY OF LDL TO IN VITRO OXIDATION C.~ R. Locher, P. Suter, and W. Vetter. Medical Policlinic, University Hospital ZUrich, Switzerland
N
HTN
43
HTN + NIDDM
8
HTN + HLP
87
HTN + HLP + NIDDM
33
Wk 0 II.4±S.7 1O.6± 11.2 !0.8H.! I I.0±4.S Wk 10 1O.0±S.9 9.3±7.1 9.8±4.6 1I.6±8.S Across HTN diagnostic groups the risk reduction diet (A) significantly (p < .00S) lowered HCY compared to the selfselected diet (B). Subjects with all 3 risk factors though failed to demonstrate a benefit. The presence of more than one cardiovascular risk factor in HTN subjects is associated with 110 reduction in HCY when folate, BI2 , and B. intake is increased. Key Words:
Oxidative mod~ication of Iow-densny lipoprotein (LOLl Increases Is atherogenic potential to Induce the accumulation 01 lipids and cells In the vascular wa•. In order to study an association between hypertension and the susceptibility of LDL oxidation, 8 normotensive patients wnhout family history of hypertension (NT), S normotensive patients wnh family history of hypertension (NT-FHI, 6 hypertensive patients with (HT-FH) and S wnhout family history of hypertension (HT) were evaluated. LOL was oxidatively modnied by Incubation with copper Ions (1.611M1. The course 01 LDL-oxidation was measured In vnro by continuous photometric rnonnoring of the diene formation through an Increase In absorption at wavelenght 234 nm at 37"C.
Compared to NT. a shorter lag-phase (antioxidative capacny) In normotensive patlSnts wnh family history was observed: NT 107±10 min vs NTIFH 87.S±11 min, p
blood pressure, homocysteine, hyperlipidemia, NIDDM
Friday, May 17, 11:50 am
Friday, May 17, 12:05 pm
RELATIONSI;lIP BETWEEN SERUM MICRONUTRIENTS AND BLOOD PRESSURE IN SOUTHWESTERN CHINESE MEN. He J, Klag MJ', Whelton PK·. Johns Hopkins Medical Institutions, Baltimore, MD
HEMATOCRIT AND HYPERTENSION INCIDENCE: TIlE GUBBIO STUDY M....QciJ.1l1•• M Laurenzi, W Panarelli, R Stamler. and J Stamler. Cbair of Nephrology, SUN. Naples. Italy; Dept. of Preventive Medicine. Northwestern Univ. Medical School, Chicago (lL), USA; Merck Sharp &. Dohme, Italy; Gubbio Hospital, Italy High hematoerit is cross-sectionally associated with hypenension. Aim of the study is to investigate this relationship prospectively. Data collected in the Gubbio Population Study at baseline and 6-year follow-up were analyzed. The cohort is 1.670 persons seen at both visits. IlOn-hypenensive at baseline, with hematocrit (HTC) measurement, and baseline ages 18-74 years. At both visits, hypertension was defined as SBP ~ 140 mm Hg, or DBP ~ 90 mm Hg, or antihypertensive treatment. Baseline and follow-up HTC were positively related (r-0.630 in men, r=0.S3O in women. p
To study the reletionship of serum celcium (Ca), magnesium (Mgl, Zinc (Znl end Copper (Cu) to systolic (SBP) and diastolic (DBPI blood pressure, we conducted e cross-sectionel study in community semples of e remote unacculturated population (521 Yi fermers) and 701 urban reSidents from southwestern Chine. Serum Ca, Mg, Zn, and Cu were measured after a 14-hour fastlOg. Blood pressure and dietary nutrient intake were measured on three consecutive deys. Multiple hnear regression enelysis was used to adjust for ege, body mass index, alcohol consumption and sodium lOtake. T~ mean SBP was 103.5 and 113.6 and mean DBP was 64.3 and 71.6 mm Hg lO fermers end urban residents, respectively. The meen level of serum micronutrlents and their partial regression coefficients on BP were as follows: Urban Residents Yi Farmers Mall s.ae o.ae Mall s.ae o.ae 8.85 1.12'" 8.06 1.28'" 0.70'" Ca, mg/dl 2.23 Mg, mg/dl 2.46 -3.83'" -1.89" 113.1 0.04' Zn. pgldl 118.2 0.06'" 106.3 Cu, pg/dl 113.0 • P<0.05; .. P
Key Words:
blood pressure, calcium. magnesium, zinc, copper
Key Words:
Hematoerit. hypertension, incidence, Gubbio study