How to Protect Your Intellectual Property

2010 Official Program Abstracts erratum front of patient safety and quality improvement over the past year. Two studies from the PSQI Committee will be presented – inadvertent intubation of post-laryngectomy patients and tracheotomy in obese patients. Sentinel articles regarding patient safety and quality improvement will be discussed including the WHO Surgical Checklist and the use of chlorohexadine as a surgical prep solution. EDUCATIONAL OBJECTIVES: 1) Understand the current “state of the union” in patient safety. 2) Understand the patient safety scenarios presented so you may practically utilize the information presented. 3) Understand the latest tools available to assist physicians with patient safety.

Facial Plastic and Reconstructive Surgery Cartilage Tissue Reshaping and Nerve Injury John S Rhee, MD, MPH (moderator); Tessa Hadlock, MD; Brian J F Wong, MD PROGRAM DESCRIPTION: A 25-year-old woman with a broad nasal tip and thin skin desires refinement in her nasal contour. Classic surgical maneuvers could be performed including a myriad of endonasal and open techniques. Regardless of technique, incisions would be needed to expose the lower lateral cartilages to be cut, sutured, scored, or morselized in order to balance the intrinsic forces that resist deformation. What if cartilage could be shaped without the need for these classic maneuvers? Cartilage is a charged polymer hydrogel and shares similarities with many polymers and plastics. Can it be shaped in the same way plastics are reshaped? Recently, several approaches have been developed in the US and Europe to reshape cartilage in living tissues by exploiting the visco-elastic nature of this unique tissue. As with all polymers, changing the physical and chemical environment of the cartilage tissue matrix leads to profound changes in the mechanical properties so that they can be exploited to achieve shape change. Several methods, techniques and devices will be discussed, including: thermoforming, lasers, and electromechanical shaping. Collectively, these minimally invasive approaches may lead to minimally invasive needle-based methods to reshape the cartilage in the face and upper airway. EDUCATIONAL OBJECTIVES: 1) Understand the current “state of the union” in translational research in facial plastics. 2) Understand the patient scenarios presented so you may practically utilize the information presented. 3) Understand the near- and longer-term possibilities either in treatment or other innovations.

How to Protect Your Intellectual Property John S Rhee, MD, MPH (moderator); Lita Nelsen, MS PROGRAM DESCRIPTION: Patents and other intellectual property ideas are an important mechanisms through which medical inventions attract investment for development and market introduction. Without IP protection from later competitors, companies and venture investors will not

717 take the risk of investment. The more innovative the invention is, the higher the risk of ultimate market adoption, and the more IP protection is needed. This presentation will briefly review the ground rules for IP protection in the academic environment. We will then discuss mechanisms for moving biomedical inventions into product development, through translational research and licensing to companies or entrepreneurial startups. MIT’s experience in working with its local business and investment community via its “entrepreneurial eco-system” will inform the discussion. EDUCATIONAL OBJECTIVES: 1) Understand how to protect your intellectual property. 2) Understand the ground rules for IP protection in the academic environment. 3) Understand mechanisms for moving biomedical inventions into product development, translational research, licensing to companies.

Nasal Airway Computer Modeling and Tissue Engineering John S Rhee, MD, MPH (moderator); Julia Kimbell, PhD; Deborah Watson, MD PROGRAM DESCRIPTION: Computer modeling: Wouldn’t it be extremely useful to have a universal or gold standard objective test, consistently predictive of surgical outcomes, providing clinicians and the healthcare industry the ability to better select surgically treatable patients and help guide the best surgical intervention to target the particular nasal anatomic deformity? With increasing sophistication of computer technology, powerful bioengineering tools are now available for investigating airflow and air conditioning in the nasal cavity. Computational fluid dynamics (CFD) techniques allow for the merger of anatomy with physiology by creating a virtual model of the nasal cavity with computed measures of airflow, heat transfer, and air humidification. Furthermore, the computed nasal geometry can be virtually modified in a manner reflecting surgical techniques and new patterns of airflow, heat and water vapor transport can be predicted that could effectively estimate surgical outcomes: e.g., virtual surgery. In this session we will review the state of the art in nasal CFD modeling, with examples of model creation, simulation, and results analysis, and provide a glimpse of the enormous promise that CFD modeling has for optimizing treatment and correction of nasal deformities. Tissue Engineering: Can you foresee a future where there are no tissue limitations for craniofacial reconstruction? Tissue engineering of human cartilage offers a unique opportunity to bridge the gap between basic science and the application of a fabricated tissue product for patients undergoing nasal, or more broadly, craniofacial reconstruction. Autologous tissue-engineered septal cartilage can now be created from a small sample of septal cartilage taken from a patient. This tissue-engineered product could eventually provide a surgeon with adequate grafting material with which to complete a nasal reconstructive case without the