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Immunological surveillance
Exp. Geront. VoL b. pp. 267. Pergamon Press 1971. Printed in Great Britain
BOOK REVIEW I m m u n o l o g i c a l Surveillance: SIR M A c F A a L ~ BtmN~r. Oxford: Pergamon Press, pp. 280. Price £3. THtS book is both a review of modern immunology and an extended presentation of Burnet's own theoretical contribution to it. The general review is of importance to gerontolog/sts as an excellent summary of the machinery involved, or potentially involved, in autoimmune age phenomena. The special consideration of aging includes a discussion of the hypotheses of clonal divergence, mutative aging, and loss of surveillance through the Hayflick phenomenon in immunocyte, probably thymocyte, clones. The hypotheses of Butch (but not those of Walford, nor the experimental work of Albright and Makinodan) are discussed. There is a select bibliography of some 350 references.
267
BOOK REVIEW I m m u n o l o g i c a l Surveillance: SIR M A c F A a L ~ BtmN~r. Oxford: Pergamon Press, pp. 280. Price £3. THtS book is both a review of modern immunology and an extended presentation of Burnet's own theoretical contribution to it. The general review is of importance to gerontolog/sts as an excellent summary of the machinery involved, or potentially involved, in autoimmune age phenomena. The special consideration of aging includes a discussion of the hypotheses of clonal divergence, mutative aging, and loss of surveillance through the Hayflick phenomenon in immunocyte, probably thymocyte, clones. The hypotheses of Butch (but not those of Walford, nor the experimental work of Albright and Makinodan) are discussed. There is a select bibliography of some 350 references.
267