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Immunotoxicology and immunopharmacology
Book reviews / Toxicology Letters 81 (1995) 79-83
82
is a vital reference and information source for initiating studies and expanding programs in immunotoxicology. Frederick
W. Oehme
Comparative Toxicology Laboratories, Kansas State University, Manhattan, KS 66506-5606, USA
SSDI 0378-4274(95)03458-W
Immunotoxicology
and
Immunopharmacology,
Second Edition. Edited by J.H. Dean, M.I. Luster, A.E. Munson and I. Kimber, Raven Press, New York, NY 10936. 1994, 761 pp., $135.00.
immune question is covered from several directions by 5 well-written chapters. Throughout the volume the editors have emphasized assessment of the immune status, and contributors have by providing responded current reality assessments of actual immune system modulations. This is a good volume, but don’t throw out your first edition; they go together like hand- andglove. Reading the 2 volumes would provide excellent orientation and upgrading for students and researchers beginning studies in this area, and working toxicologists and environmental scientists will benefit from the scope and depth offered by the cadre of authoritative writers. This is an outstanding book that offers state-of-the-art information on how our immune system is affected by the chemicals to which it is exposed. Frederick
In the 10 years since the first edition of this volume appeared, the study and information known about the immune system has expanded dramatically. The second edition of this focused book documents that growth. Although 3 of the 4 editors from the first edition remain the same, the similarity between the 2 editions ends there. A total 42 chapters involving 89 authors (29 international) have resulted in a volume with 50% more pages than the first edition. The index is exactly doubled in size. While the previous work dealt with function and mechanisms, general groups of compounds (drugs and xenobiotics) and experimental animals versus man, now the themes are focused more on assessment, specific immune modulations from a host of environmental agents, impacts on major organs, autoimmunity, clinical response and risk assessment. There is special emphasis on the clinical aspects and the specific effects on immunity of individual chemicals. This is a handy place to get the latest information on immune system impacts from cannabinoids, ethanol, a variety of drugs, pesticides, organic solvents, recombinant cytokines, lead and arsenic, polycyclic aromatic hydrocarbons, TCDD and mycotoxins. This latter group of agent-oriented chapters is particularly instructive for clinicians with patients having occupational or environmental exposures to such compounds. The auto-
W. Oehme
Comparative Toxicology Laboratories, Kansas State University, Manhattan, KS 66506-5606, USA
SSDI 0378-4274(95)03459-X
Carcinogenesis. Edited by M.P. Waalkes and J.M. Ward. Raven Press Ltd, New York, NY 10036. 1994, 478 pp., $100.00.
This fifteenth volume of the Target Organ Toxicology Series examines the carcinogenic specificity of various chemicals to particular target organs in laboratory animals and in man. The first 2 chapters detail the general principles of chemical carcinogenesis and the chemicals causally associated with cancers. The next 10 chapters deal with carcinogenesis of the various target sites, such as liver, kidneys, gastrointestinal tract, respiratory tract and skin. The final chapter investigates pathology procedures appropriate for laboratory animal carcinogenesis studies. While the chapters focus on laboratory animal studies, they are directly relevant to humans, as pointed out in Chapter 2. Photomicrographs are abundant throughout the text to aid recognition of the various cancers
82
is a vital reference and information source for initiating studies and expanding programs in immunotoxicology. Frederick
W. Oehme
Comparative Toxicology Laboratories, Kansas State University, Manhattan, KS 66506-5606, USA
SSDI 0378-4274(95)03458-W
Immunotoxicology
and
Immunopharmacology,
Second Edition. Edited by J.H. Dean, M.I. Luster, A.E. Munson and I. Kimber, Raven Press, New York, NY 10936. 1994, 761 pp., $135.00.
immune question is covered from several directions by 5 well-written chapters. Throughout the volume the editors have emphasized assessment of the immune status, and contributors have by providing responded current reality assessments of actual immune system modulations. This is a good volume, but don’t throw out your first edition; they go together like hand- andglove. Reading the 2 volumes would provide excellent orientation and upgrading for students and researchers beginning studies in this area, and working toxicologists and environmental scientists will benefit from the scope and depth offered by the cadre of authoritative writers. This is an outstanding book that offers state-of-the-art information on how our immune system is affected by the chemicals to which it is exposed. Frederick
In the 10 years since the first edition of this volume appeared, the study and information known about the immune system has expanded dramatically. The second edition of this focused book documents that growth. Although 3 of the 4 editors from the first edition remain the same, the similarity between the 2 editions ends there. A total 42 chapters involving 89 authors (29 international) have resulted in a volume with 50% more pages than the first edition. The index is exactly doubled in size. While the previous work dealt with function and mechanisms, general groups of compounds (drugs and xenobiotics) and experimental animals versus man, now the themes are focused more on assessment, specific immune modulations from a host of environmental agents, impacts on major organs, autoimmunity, clinical response and risk assessment. There is special emphasis on the clinical aspects and the specific effects on immunity of individual chemicals. This is a handy place to get the latest information on immune system impacts from cannabinoids, ethanol, a variety of drugs, pesticides, organic solvents, recombinant cytokines, lead and arsenic, polycyclic aromatic hydrocarbons, TCDD and mycotoxins. This latter group of agent-oriented chapters is particularly instructive for clinicians with patients having occupational or environmental exposures to such compounds. The auto-
W. Oehme
Comparative Toxicology Laboratories, Kansas State University, Manhattan, KS 66506-5606, USA
SSDI 0378-4274(95)03459-X
Carcinogenesis. Edited by M.P. Waalkes and J.M. Ward. Raven Press Ltd, New York, NY 10036. 1994, 478 pp., $100.00.
This fifteenth volume of the Target Organ Toxicology Series examines the carcinogenic specificity of various chemicals to particular target organs in laboratory animals and in man. The first 2 chapters detail the general principles of chemical carcinogenesis and the chemicals causally associated with cancers. The next 10 chapters deal with carcinogenesis of the various target sites, such as liver, kidneys, gastrointestinal tract, respiratory tract and skin. The final chapter investigates pathology procedures appropriate for laboratory animal carcinogenesis studies. While the chapters focus on laboratory animal studies, they are directly relevant to humans, as pointed out in Chapter 2. Photomicrographs are abundant throughout the text to aid recognition of the various cancers