Index of articles published

RESEARCH IN IMMUNOLOGY

604 immunity ; PERFEXT method, SEB, LPS, Quantitative measurement . , . . . . . . . . . . . . . 257 Immunodeficiency, T lymphocyte, Rhodococcus equi, Virulence, Pneumonia, AIDS; Mouse . . . . . 387 Immunorestoration, Glycopeptidolipid, Megakaryocyte, Haematopoietic stem cell, Mycobacterium chelonae; pGPL-MC, CFU-S, pre-CFU-S, CFU-Meg . . . . . . . . . . . . . . 127 Inflammation, Asthma, T lymphocyte, Airway responsiveness, Allergy, Lung ; Cytokines, Eosinophils, Inter7 leukins, Mouse; Forum . . . . . Interleukin 15, NK cell, Haematopoiesis, HLA, MHC, T lymphocyte, Receptor; Evolution, Mouse, 145 Rat; Forum . . . . , . . . . . Internalization, TCR ; TCR-CD3, Superantigens, Internalization motifs, Downregulation, Degradation . . . . . . . . . . . . . . . . 231 Liver, Schistosomiasis, Granuloma, Myelopoiesis ; Colony-forming cell, Inflammation . _ . . . _ . 437 Local immunity, Cytokine, IL2, IFNY; PERFEXT method, SEB, LPS. Quantitative measurement . 257 Lung, Asthma, T lymphocyte, Airway responsiveness, Allergy, Inflammation; Cytokines, Eosinophils, Interleukins, Mouse; Forum . .. 7 Macrophage, HBV, TNFa, B lymphocyte; THF-1 and Namalwa cell lines, mRNA . . . . . . . . 399 Macrophage, Mucosa, Adjuvant, T lymphocyte, B lymphocyte, Dendritic cell, Cytokine, Oral tolerance,

Clonal

deletion

; Inflamma-

tory bowel diseases, Animal models ; Forum . . . . . . . . 489 Megakaryocyte, Immunorestoration, Glycopeptidolipid, Haematopoietic stem cell, Mycobacterium chelonae ; pGPL-MC, CFU-S, preCFU-S, CFU-Meg . . . . . . . 127 MHC class II, HLA-DR, SEA, Superantigen; TCR; Review . , . . 217 MHC, NK cell, Interleukin 15, Haematopioesis, HLA, T lymphocyte, Receptor; Evolution, Mouse, Rat; 145 Forum . . . . , . . . . . MHC, NOD mouse, Diabetes, T lymphocyte, p cell ; Autoimmunity, IDDM; Forum . .. . . . 285 Monoclonal antibody, ELISA, Polyreactivity, IgG, Temperature 267 Mucosa, Adjuvant, T lymphocyte, B lymphocyte, Macrophage, Dendritic cell, Cytokine, Oral tolerance. Clonal deletion ; Inflammatory bowel diseases, Animal models ; Forum . . . . . . . . . . . 489 Mucosa, Helicobacterpylori, Cellular

immunity, Humoral immunity ; Immunogenesis; Review . . . 91 Mycobacterium chelonae, Immunorestoration, Glycopeptidolipid, Megakaryocyte, Haematopoietic stem cell ; pGPL-MC, CFU-S, preCFU-S, CFU-Meg . . . . . . 127 Myelopoiesis, Schistosomiasis, Granuloma, Liver; Colony-forming cell, Inflatnmation . . . . . . . . 437 NK cell, Interleukin 15, Haematopoiesis, HLA, MHC, T lymphocyte, Receptor; Evolution, Mouse, Rat; Forum . . . . . . . . . . 145 NOD mouse, Diabetes, MHC, T lymphocyte. p cell ; Autoimmunity, IDDM; Forum . . . . . . . . . 285 Oral tolerance, Mucosa, Adjuvant, T lymphocyte, B lymphocyte, Macrophage, Dendritic cell, Cytokine, Clonal deletion ; Inflammatory bowel diseases, Animal models ; 489 Forum . . . .. PAF, Haematopoiesis, Bone marrow; Human, Marrow mononuclear and stromal ceIIs, Cytokines . 119 Pneumonia, T lymphocyte, Rhodococcw equi, Virulence, Immunodeficiency. AIDS; Mouse . . 387 Polyreactivity, ELISA, Monoclonal antibody, IgG, Temperature. . . 267 Receptor, NK cell, Interleukin 15, Haematopoiesis. HLA, MHC, T lymphocyte ; Evolution, Mouse, Rat; Forum . . . . . . . 145 Rhodococcus equi, T lymphocyte, Virulence, Itnmunodeficiency, Pneumonia, AIDS; Mouse . . . . 387 Schistosomiasis, Granuloma, Liver, Myelopoiesis ; Colony-forming cell, Inflammation . . . . . . . 437 SEA, HLA-DR, MHC class II, Superantigen; TCR: Review . . . . 217 Staphylococcal enterotoxin, Superantigen, T lymphocyte; Times and Trends .. . . . .. . . . . . 373 Superantigen, HLA-DR, MHC class II, SEA; TCR; Review . . . . 217 Superantigen, T lymphocyte, Staphylococcal enterotoxin ; Times and Trends , . .... . . . 373 T lymphocyte, Asthma, Airway responsiveness, Allergy, Lung, Inflammation ; Cytokines, Eosinophils, lnterleukins, Mouse; Forum 7 T lymphocyte, Gene targeting, B lymphocyte ; KO mice; Forum. . 447 T lymphocyte, Mucosa. Adjuvant, B lymphocyte, Macrophage, Dendritic cell, Cytokine. Oral tolerance, Clonal deletion ; Inflammatory bowel diseases, Animal models ; Forum . . ,. . . 489 T lymphocyte, NK cell, Interleukin IS. Haematopoiesis, HLA, MHC,

Receptor; Evolution, Mouse, Rat; Forum . . . . . . . . . . . . . 145 T lymphocyte, NOD mouse, Diabetes, MHC, /3 cell ; Autoimmunity, IDDM; Forum . . . . . . . . 285 T lymphocyte, Rhodococcus equi, Virulence, Immunodeficiency, Pneumonia, AIDS; Mouse . . . . . . 387 T lymphocyte, Superantigen, Staphylococcal enterotoxin ; Times and Trends . . . . . . . . . I . . . . . . 373 TCR, Internalization ; TCR-CD3, Superantigens, Internalization motifs, Downregulation, Degradation . . . . . . . . . . . . . . . . . . 231 Temperature, ELISA, Polyreactivity, Monoclonal antibody, IgG . 267 TNFa, HBV, Macrophage, B lymphocyte; THP-1 and Namalwa cell lines! mRNA .... . . 399 Transmissible gastroenteritis virus, Coronavirus, IFNol; ELISA, ELISPOT, Foetus, Pig . . . . 247 Virulence. T lymphocyte, Rhodococcus equi, Immunodeficiency, Pneumonia. AIDS: Mouse . . 387

INDEX OF ARTICLES PUBLISHED 68th Forum in Immunology : “Biology of airway inflammation : from immunology to altered responsiveness”. Introduction, B.B. VARGAF~G. . . 7 Basic concepts in lung immunology, L.W.

POULTER

. . ..

.

. .

8

Lymphocyte subsets in experimental bronchopulmonary inflammation and hyperresponsiveness, A.J. COYLE and M. KOPF . . 13 Adhesion molecules and the recruitment of eosinophils to the airways, P.A.J. HENRICKS, P.G.M. BLOEMEN and F.P. NumMP .. . . 18 Immunobiology of eosinophils in allergy and inflammation, M. CAPRON and P. DESREUMAUX 29 Cytokines involved in the downregulation of allergic airway inflamma[ion. M. PRETOLANI and M. GOLDMAN . . . . . . 33 Interleukins involved in the pathogenesis of chronic airway inflammation. J.A. LASKY and A.R. BRODY . . . , . 39 Role of the respiratory epithelium in 48 asthma. D.13. JACOBY . . . Smooth muscle as a direct or indirect target accounting for bronchopul-

INDEX monary WILLS-KARP

hyperresponsiveness, . . . .

M.

. . . . . . .

59

Genetics of airway responsiveness in the inbred mouse, G.T. DE SANCTIS and J.M. DRAZEN . . . . . . . 73

Original articles: Immune responses to mucosal infection: the Helicobacter pylori paradigm, R.L. FERRERO . . . . . 91 Circulating cell adhesion molecules in HIVI-infected patients as indicator markers for AIDS progression, P. GALEA, C. VERMOT-DESROCHES, C. LE CONTEL, J. WUDENES and J.-C. CHERMANN . . . . .. . . . . 109 Production and metabolism of plateletactivating factor by human bone marrow cells, F. DUFUS, F. ROUGIER, F. TRIMOREAU, E. OSTYN, C. DULERY, 119 V. PRALORAN and Y. DENIZ~T Stimulatory effects of polar glycopeptidolipids of Mycobacterium ch~lonae on murine haematopoietic stem cells and megakaryocyte progenitors, S. VINCENT-NAULLEAU, D. THIRALJLT. T. NEWAY and C. PILET 127

OF ARTICLES

PUBLISHED

for MHC

class I molecules, A. E. VIVIER and L. . . . . . . . . . . . . . 172 NKRPlA and p40 molecules are involved in regulation of activation and maturation of human NK cells, A. POGGI, E. TOMASELLO and P. COSTA . .. .. . 179 NK receptors and signalling, G. PALMIERI and A. SANTONI . . . . . 184 Events in the adaptation of natural killer cell receptors to MHC class I polymorphisms, P. PARHAM . . . . . 190 Ontogeny of NK cells and the bone marrow microenvironment: where does IL15 fit in?, I.J. PUZANOV, N.S. WILLIAMS, J. SCHATZLE, P.V. SIVAKUMAR, M. BENNETT and V. KUMAR . . . . 195 CAMBIAGGI, OLCESE

Times and Trends: “Bazinc” instinct: how SEA attracts MHC class II molecules. J. THIBODEACJ, P.M. LAVOIE and P.-A. CAZENAVE

. .

.

. .

217

Original articles: 69th Forum in Immunology : “NK cell functions and receptors”. Introduction, L. MOREPA , . . . 145 HLA class-I-specific NK receptors belong to two distinct molecular families and display inhibitory or activating function, C. CANTCINI and R. BIASSON~ . . . . . . . . . . . . 146 HLA class-I-specific inhibitory receptor in human T lymphocytes: interference with T-cell functions, M.C. MINGARI, M. PONTE, C. VITALE, F. SCHIAVETTI, R. BELLOMO, S. BERTONE and L. NANNI . . . . . 150 The CD94/NKG2 C-type lectin receptor complex in recognition of HLA class I molecules, M. LOPEZBOTET, M. CARRETERO, T. BELL~N, J.J. PBREZ-VILLAR, M. LLANO and F. NAVARRO .. . . . . . , . . . 155

The role of natural killer cells in allograft responses to MHC antigens in the rat, B. ROLSTAD and J.T. VAAGE . . . . 159 Role for NK-cell-associated Fas ligand in cell-mediated cytotoxicity and apoptosis, C.M. EISCHEN and P.J. LEIBSON . . . .. 164 Immunoglobulin superfamily inhibitory receptors: from natural killer cells to antigen-presenting cells, M. COLONNA

Inhibitory

. . .

.

.

and activatory

.

169

receptors

Differential cytosolic tail dependence and intracellular fate of T-cell receptors internalized upon activation with superantigen or phorbol ester, F. NIEDERGANG, E. SAN Jose, B. RUBIN, B. ALARC~N, A. DAUTRYVAR~AT and A. ALCOVER . 231 In vivo study of interferon-alpha-secreting cells in pig foetal lymphohaematopoietic organs following in utero TGEV coronavirus injection, I. SpLfcH& Z. &%AKov.& M. SINKORA, J. !?INKORA, I. TREBICHAVSK?, H. LAUDE and B. CHARLEY 247 “PERFEXT” : a direct method for quantitative assessment of cytokine production in vivo at the local level, M. VILLAVEDRA, H. CAROL, M. HJULSTROM, J. HOLMGREN and C. CZERKINSKY . .. . . 257 Effect of temperature on the reactivities of polyreactive and monospecifit monoclonal IgG antibodies, H. LABROUSSE. M. ADIB-CONQUY and S. AVRAMEAS .. . . . 267

70th Forum in Immunology: “The NOD mouse”. Introduction, J.F. BACH and D. MATHIS . . .. 285 Questions about NOD mouse diabetes, I.R. COHEN 286

Insights into the chemistry and biology of the I-As7 class II molecule, E. CARRASCO-MARIN, 0. KANAGAWA and E.R. UNANUE . . . . . . . 291 Mechanisms underlying the loss of self tolerance in NOD mice, M.A. ATKINSON , . . . . . . . . . . . . 30 1 The role of TNFa(. and related cytokines in the development and function of the autoreactive T-cell repertoire, A. COPE, R. ETTIN~ER and H. MCDEVI~ . . . . . . . . 307 Immunobiology of autoimmune diabetes, K.J. LAFFERTY . . , . . 313 CD4+ and CD8+ T lymphocytes: clarification of their pathogenic roles in diabetes in the NOD mouse, T.W.H. Iby, H.L. CHAPLIN.J.L. PARKER,L.A. STFPHENSand H.E. THOMA.S . . 320 The role of CD4 and CD8 T cells in type I diabetes in the NOD mouse, F.S. WONG and C.A. JANEWAY, Jr. . . . . . . . . . . . 327 Autoimmune diabetes : how many steps for one disease?, J.F. BACH, L. CHATENOUD, A. HERBELIN, J.M. GOMBERT and C. CARNAUD . . . . . . 332 Characterization of immunodominant peptide determinants of IDDMassociated autoantigens in the NOD mouse, M.A. ZECHEL, P. CHATURVEDI and B. SINGH

. . .

.

.

338

Role of T-cell anergy and suppression in susceptibility to IDDM, I. BERGEROT, G. ARREAZA, M. CAMERON, H. CHOU and T.L. DELOVITCH 348

Times and Trends : Superantigens: a tool to gain new insights into cellular immunity, S. FLORQUIN and L. AALDERING 373

Original articles : T-cell response during Rhodococcus equi infection in a murine experimental model, P. MATSIOTA-BERNARD. I. LAIR, E. VOGIATZAKIS and A. BERNEMANN . . . .. . . 387 Effect of hepatitis B virus on tumour necrosis factor TNFa gene expression in human THP-1 monocytic and Namalwa B-cell lines, J. OQUENDO. S. KARRAY, P. GALANAUD and M.-A. PIXI . 399

1997ENII Conference: Molecular and cellular components of the immune system, chaired by H.C. CLEVERS alld L. ADORINI 4 11

606

RESEARCH

Original article :

Generation and analysis of conditional mutant mice, U.A.K. BETZ . . 475

Haematopoietic capacity of colonyforming cells mobilized in hepatic inflammatory reactions as compared to that of normal bone marrow cells, H.S. DUTRA, M.I.D. Rossr, S.P. AZEVEDO, MC. EL-CHEIKH and R. BOROJEVIC . . . . . . . . . . . 437

“Gene targeting in immunology”. Introduction, R. KUHN and W. MOLLER . . . . . . . . . . . . . . . . . . 447 On the role of the common cytokine receptor y chain in B-cell vs. T-cell development, L.I. SHARARA. C.A.J. VOBHENRICH, W. MULLER and J.P. .. . . . .

.. . . .

. .

72nd Forum in Immunology : “Tolerance and immunity in the mucosal immune system”. Introduction, W. STR~BER and R.L. COFFMAN . . . . . . . . 489

I. Antigen presentation in the mucosalimmune system

71st Forum in Immunology :

DISANTO

IN IMMUNOLOGY

449

Inflammation and TGFPl : lessons from the TGFPl null mouse, A.B. KULKARN~and S. KARLSON. . . 453 Antigen receptor signalling in B cells, A. TARAKHOVSKY . . . . . . 457 Insights into the control of immunoglobulin class switch recombination from analysis of targeted mice, M.G.O. LORENZ and A. RADBRUCH . . . . . . . . . . . . 460 Gene targeting of adhesion molecules, N. WAGNER . . . . . . . 463 The role of FcR in immunity : lessons from gene targeting in mice, J.S. VERBEEK, W.L.W. HAZENBOS, P.J.A. CAPEL and J.G.J. VAN DE WINKEL . . . . 466

Peyer’s patch dendritic cells and the induction of mucosal immune responses, B. KELSAL.L and W. STROBER . . . . . . . . . . . . . . . 490 The role of the epithelium in mucosal immunity. L. MAYER . . . . . . 498

II.

Immunity in the mucosal immune system

The mechanism of cholera toxin adjuvanticity. N. LYCKE . . . . . . 504 Adjuvants or live delivery systems for the characterization of mucosal T helper subset responses, J.W. LILLARQ Jr. and J. MCGHEE .. . 520

III. Tolerance in the mucosal immune system Oral tolerance: cytokine milieu in the gut and modulation of tolerance by cytokines, H.L. WEINER, P.A. GONELL.A, A. SLAVIN and R. MARON . . . . . . . . . . 528 The role of clonal deletion and anergy in oral tolerance, J.M. BENSON and C.C. WHITACRE . . . . . 533 Bystander suppression induced by oral tolerance, M.G. von HERRATH 541

Oral tolerance and its modulation by anti-cytokines, T. MARTH and W. STROKER .. . . .. . . . . . 554 J.A. KAPP and Y. KE: The role of ~8 TCR-bearing T cells in oral tolerance . . . . . . . . . . . . . . 561

IV. Immunity and tolerance to normal intestinal microbial flora The influence of normal microbial flora on the development of chronic mucosal inflammation, R.B. SARTOR . . . . . . . . , . . . , 567 CD4+ T-cell subsets in the regulation of inflammatory responses in the intestine, F. POWRIE, S. MAUZE and R.L. COFFMAN . . . . . . . . . 576 Induction of colitis in IL2-deficient mice: the role of thymic and peripheral dysregulation in the generation of autoreactive T cells, R.O. EHRHARDT and B. LUDVIKSSON 582 Responses to self and non-self intestinal microtlora in health and inflammatory bowel disease, R. DLJCHMANN, M.F. NEURATH and K.H. MEYER zum B~SCHENFEI.DE 589

BOOKS

RECEIVED

P. & ANDERSON, J.A. Allergic diseases, diagnosis and treatment . . . . . . . . . . . , 203 MEYERS, R.A. - Encyclopedia of molecular biology and molecular medicine, Vols 4, 5 and 6 . . 429 LIBERMANS,