204 Written in a clear, easy-to-read style, this important reference discusses FDA regulations on validated chromatogranhic methods, presents simple published handling procedures, in&ding robotics, highlights state-of-the-art technology for thin-layer, gas, and high-performance chromatography and describes various chromatographic approaches to methods development. Chromatographic Analysis of Pharmaceuticals provides a time-saving resource for analytical, bioanalytical, pharmaceutical, organic, clinical, physical, quality control, and process chemists and biochemists; chromatographers; pharmaceutical scientists; and professional seminars and graduate-level courses in the above disciplines. Mass Spectrometry of Biological Materials, Practical Spectroscopy Series/s, edited by CN McEwen and BS Larsen. Marcel Dekker Inc, New York, 1990. Hardback, illustrated, pp 536, $ 125.00 (US and Canada), $ 150.00 (all other countries)
Documenting the latest advances in the application of mass spectrometrv (MS) to the biological sciences, this important volume discusses valuable techniques for-sample handling, pm&cation, data interpretation, and MS methods, including protein/peptide sequencing, isotope dilution /MS, biological matrix analysis, gas chromatography/MS and liquid chromatography/MS. Mass Spectrometrv of Biological Materials emphasizes mass spectrometry’s role in determining primary chemical structures. It contains nearly 300 illustrations, including diagrams, tables, and photographs and covers the analysis of selected biological matrices such as natural and recombinant proteins and glycoproteins, monoamines, indoles, and trace amines, lipids, sterols, bile acids, steroids, pesticide metabolites, and others. It provides an armamentarium of methods applicable to problems outside this volume’s scope. With more than 500 citations of relevant literature, Mass Spectrometry of Biological Materials is an essential reference for mass spectrometrists, analytical and protein chemists, biochemists, molecular biologists, and biotechnologists.
Selenium in Bioloav and Medicine. Proceedines of the 4th International Symposium on Se&ium in Biology and Medicine, July 18-21, 1988, Ttibingen, FRG, edited by A Wendel. Springer-Verlag, Berlin, 1989. pp 330, DM 176.00
This book gives an account of the most recent development in the understanding of the essential trace element selenium with respect to its role in animals and man. It is divided into five sections covering biochemistry, metabolism, pharmacology, human nutrition and epidemiology, and the interaction of selenium with malignant diseases. Primary new information is available on the synthesis of selenoproteins, metabolic selenium-dependent modulations in animals, and brand-new results on the development of a new, selenium-containing anti-inflammatory drug. For the first time, data from China are presented on the chronic toxicity of selenium in man. A critical appraisal of the debate on the anticarcinogenic effect of selenium is given. Recommended daily intakes of selenium for man and epidemiological data on different countries of the world are reported. Polymers. Properties and Applications, vol 13, Controlled Release. A Quantitative Treatment, edited by LT Fan and SK Singh, SpringerVerlag, Berlin, 1989. pp 250, DM 298.00
This book presents the quantitative aspects of controlled release systems. The factors or parameters governing the performance of these systems are reviewed and discussed, along with the principles for their design. The major mathematical models applicable to the systems are classified and analyzed. A stochastic approach to modelling the diffusion process pertinent to some of the systems is also introduced. The book orovides an introduction to students and scientists in this area with a comprehensive coverage of the principles (both qualitative and quantitative) behind the maior classes of controlled release svstems. The book can’be a ready reference for researchers and practitioners in analyzing and interpreting their experimental results.