- Email: [email protected]
MEASURING SULPHONAMIDE ACTIVITY
223
" XBD=1526 XBD=1622 XBD=1976 XBD=2138 XBD=2313 XBD=2445 XHG=1371 XHG=1578 XHG=1669 XHG=2030 XHG=2189 XHG=2365 XHG=2495 YBD=222 YBD=221 YHG=189>criteria YHG=187>of YHG=188>bacteriostasis. YHG=187>Thus YHG=187>WYSS YHG=187>and YHG=187>his " XBD=2556 XBD=342 XHG=744 XBD=422 XBD=637 XBD=722 XBD=957 XBD=1060 XBD=1142 XBD=1309 XHG=138 XHG=364 XHG=445 XHG=661 XHG=980YBD=233 XHG=1081 XHG=1164 YBD=223 YBD=232 YBD=222 YBD=221 YBD=221YHG=189>happiness YBD=222 YHG=189>determine YHG=189>his YHG=188>stability, YHG=188>his YHG=188>and YHG=188>his YHG=188>useful-
" " " " " " " "
XBD=2555XHG=729 XBD=231 XBD=363 XBD=615 XBD=696 XBD=863 XBD=1092 XBD=1206 XBD=1311 XBD=1587 XBD=1810 XBD=1905 XBD=2124 XBD=2197 XBD=2319 XHG=139 XHG=284 XHG=398 XHG=652 XHG=902YBD=277 XHG=1125 XHG=1241 XHG=1370 XHG=1616 XHG=1836 XHG=1935 XHG=2152 XHG=2220 XHG=2347 YBD=272 YBD=282 YBD=271 YBD=281 YBD=270YHG=237>death, YBD=271 YBD=282 YHG=249>ness. YHG=238>The YHG=238>proximity YHG=236>of YHG=236>hardship YHG=237>and YHG=237>colleagues YHG=237>observed YHG=237>the YHG=238>quantity YHG=236>of YHG=236>drug YHG=248>necessary XBD=314 XHG=829 XBD=383 XBD=648 XBD=802 XBD=918 XBD=1145 XBD=1198 XBD=1312 XBD=1413 XBD=1585 XBD=1806 XBD=1989 XBD=2060 XBD=2138 XBD=2287 XBD=2361 XBD=2479 XBD=2557 XHG=139 XHG=341 XHG=407 XHG=675 XHG=947YBD=330 XHG=1174 XHG=1225 XHG=1368 XHG=1442 XHG=1616 XHG=1835 XHG=2019 XHG=2093 XHG=2168 XHG=2318 XHG=2391 XHG=2504 YBD=331 YBD=320 YBD=319 YBD=319 YBD=319YHG=286>give YBD=331 YBD=321 YBD=320 YHG=287>ubiquity YHG=286>of YHG=286>destructive YHG=285>forces YHG=286>existence YHG=297>a YHG=297>new YHG=286>reduce YHG=286>bacterial YHG=286>growth YHG=287>in YHG=287>16 YHG=286>hours YHG=288>to YHG=285>half YHG=286>its XBD=323 XHG=803 XBD=425 XBD=528 XBD=644 XBD=713 XBD=779 XBD=940 XBD=1070 XBD=1208 XBD=1264 XBD=1312 XHG=140 XHG=377 XHG=448 XHG=552 XHG=670 XHG=737 XHG=964YBD=367 XHG=1096 XHG=1231 XHG=1289 YBD=379 YBD=368 YBD=374 YBD=374 YBD=367YHG=333>earlier YHG=336>meaning. YHG=335>In YHG=335>this YHG=345>war, YHG=345>as YHG=335>in YHG=345>ones, YHG=334>there YHG=334>is YHG=345>a XBD=2120 XBD=2201 XBD=2293 XBD=2487 XBD=2557 XHG=1933 XHG=2145 XHG=2224 XHG=2319 XHG=2512 YBD=380 YBD=369 YHG=335>3 YHG=335>by YHG=336>the YHG=335>absence YHG=335>of judged XBD=1523 XBD=1727 XHG=1369 XHG=1548 YBD=368 YBD=370 YHG=334>normal YHG=338>amount. XBD=352 XHG=923 XBD=455 XBD=530 XBD=634 XBD=888 XBD=968 XBD=1160 XBD=1313 XHG=140 XHG=385 XHG=489 XHG=565 XHG=670 XHG=1000YBD=416 XHG=1214 YBD=429 YBD=415 YBD=426 YBD=417YHG=382>of YHG=384>significant YHG=382>fall YHG=383>in YHG=382>the YHG=382>frequency YHG=382>suicide. YHG=382>New XBD=1510 XBD=1694 XBD=1866 XBD=1919 XBD=2050 XBD=2161 XBD=2386 XBD=2556 XHG=1372 XHG=1540 XHG=1724 XHG=1897 XHG=1951 XHG=2080 XHG=2189 XHG=2416 YBD=416 YBD=428 YBD=429 YBD=418 YBD=419 YBD=430 YHG=383>visible YHG=384>growth YHG=384>during YHG=386>5 YHG=384>days YHG=384>and YHG=384>therefore YHG=384>placed XBD=232 XHG=799 XBD=312 XBD=461 XBD=527 XBD=641 XBD=776 XBD=892 XBD=1083 XBD=1244 XBD=1313 XHG=140 XHG=254 XHG=336 XHG=484 XHG=551 XHG=668 XHG=916YBD=464 XHG=1107 XHG=1269 YBD=467 YBD=466 YBD=465 YBD=471 YBD=464 YBD=475YHG=431>that YBD=464 YHG=434>aims YHG=431>for YHG=431>which YHG=434>to YHG=430>live, YHG=431>work YHG=431>satisfies YHG=431>higher YHG=441>as XBD=219 XHG=869 XBD=287 XBD=420 XBD=676 XBD=838 XBD=892 XBD=1145 XBD=1219 XBD=1312 XHG=141 XHG=246 XHG=314 XHG=447 XHG=705 XHG=919YBD=512 XHG=1174 XHG=1242 YBD=516 YBD=515 YBD=514 YBD=520 YBD=524 YBD=513YHG=491>a YHG=481>well YHG=493>as YHG=492>more YHG=479>immediate YHG=479>needs, YHG=480>tightening YHG=478>of YHG=479>the XBD=258 XHG=634 XBD=400 XBD=526 XBD=615 XBD=885 XBD=1084 XBD=1183 XBD=1313 XHG=141 XHG=277 XHG=419 XHG=544 XHG=901YBD=573 XHG=1103 XHG=1201 YBD=566 YBD=563 YBD=562 YBD=573 YBD=563YHG=530>community YBD=562 YHG=530>bonds YHG=530>which YHG=529>draw YHG=539>our YHG=525>together YHG=528>and YHG=529>unite XBD=170 XHG=814 XBD=283 XBD=373 XBD=475 XBD=542 XBD=788 XBD=978 XBD=1053 XBD=1310 XHG=141 XHG=192 XHG=305 XHG=395 XHG=499 XHG=562 XHG=1001YBD=622 XHG=1075 YBD=615 YBD=613 YBD=612 YBD=611 YBD=612YHG=578>provide YBD=623 YHG=581>it YHG=580>with YHG=579>the YHG=581>rest YHG=577>of YHG=577>humanity, YHG=589>an YHG=578>inspiration
WOOD
" XBD=1185 |>" XBD=257 XBD=378 XBD=528 XBD=601 XBD=748 XBD=851 XBD=1311 XHG=141 XHG=288 XHG=411 XHG=558 XHG=632 XHG=782 XHG=883 XHG=1211 YBD=663 YBD=662 YBD=661 YBD=660 YBD=661 YBD=662 YHG=629>which YHG=628>does YHG=627>much YHG=629>to YHG=626>offset YHG=627>the YHG=627>circumstances YHG=628>-that
" XBD=993 XBD=223 XHG=806 XBD=294 XBD=662 XBD=775 XHG=141 YBD=710 XHG=251 XHG=325 XHG=695 YBD=713 YHG=677>neurosis. YBD=711 YBD=721 YHG=678>lead YHG=681>to YHG=677>discouragement YHG=676>and MEASURING SULPHONAMIDE ACTIVITY
" XBD=1244 XBD=1313XHG=507 XBD=275 XBD=433 XBD=494 XBD=896 XBD=1051 XHG=190 XHG=292 XHG=450 XHG=913YBD=873 XHG=1069 XHG=1262 YBD=864 YBD=874 YBD=863 YBD=873 YBD=874YHG=829>chemotherapeutic YBD=863 YHG=830>THE YHG=829>dosage YHG=828>of YHG=831>agents YHG=828>depends YHG=840>on " XBD=1313 XBD=165 XHG=704 XBD=279 XBD=458 XBD=518 XBD=689 XBD=830 XBD=891 XBD=1030 XBD=1168 XBD=1227 XHG=847 XHG=144 XHG=179 XHG=294 XHG=474 XHG=529 XHG=902YBD=912 XHG=1045 XHG=1184 XHG=1243 YBD=914 YBD=924 YBD=919 YBD=923 YBD=912 YBD=912YHG=877>of YHG=892>a YHG=879>large YHG=878>number YHG=877>factors, YHG=889>many YHG=878>which YHG=878>relate YHG=881>to YHG=878>the " XBD=1312 XBD=239 XHG=777 XBD=416 XBD=549 XBD=745 XBD=923 XBD=1150 XHG=145 XHG=305 XHG=446 XHG=580 XHG=956YBD=969 XHG=1184 YBD=963 YBD=961 YBD=968 YBD=962YHG=928>action, YHG=929>host. YHG=928>Even YHG=928>their YHG=928>in-vitro YHG=927>however, YHG=929>varies
" " " " "
XBD=1313XHG=665 XBD=289 XBD=433 XBD=640 XBD=900 XBD=1006 XBD=1100 XBD=1216 XHG=144 XHG=310 XHG=456 XHG=926YBD=1017 XHG=1029 XHG=1124 XHG=1240 YBD=1022 YBD=1011 YBD=1010 YBD=1011YHG=977>conditions, YBD=1021 YBD=1022 YHG=977>greatlv YHG=977>under YHG=976>different YHG=977>and YHG=980>not YHG=977>long YHG=988>ago XBD=174 XHG=868 XBD=273 XBD=467 XBD=544 XBD=843 XBD=911 XBD=1208 XBD=1315 XHG=145 XHG=198 XHG=299 XHG=492 XHG=568 XHG=937YBD=1060 XHG=1234 YBD=1061 YBD=1060 YBD=1071YHG=1029>to YHG=1029>it YHG=1038>was YHG=1026>counted YHG=1036>an YHG=1026>achievement YHG=1026>demonstrate YHG=1037>any XBD=299 XHG=842 XBD=479 XBD=534 XBD=672 XBD=826 XBD=886 XBD=1049 XBD=1313 XHG=146 XHG=310 XHG=492 XHG=549 XHG=686 XHG=898YBD=1110 XHG=1063 YBD=1111 YBD=1121 YBD=1120 YBD=1121 YBD=1121YHG=1074>of YHG=1077>in-vitro YHG=1076>activity YHG=1076>in YHG=1087>many YHG=1078>agents YHG=1075>proved YHG=1075>therapeutic XBD=264 XHG=821 XBD=425 XBD=789 XBD=890 XBD=1067 XBD=1313 XHG=146 XHG=316 XHG=456 XHG=920YBD=1159 XHG=1098 YBD=1160 YBD=1170 YBD=1159 YBD=1170YHG=1126>the YHG=1125>value. YHG=1125>With YHG=1125>sulphonamides, YHG=1124>factors YHG=1126>governing XBD=299 XHG=628 XBD=487 XBD=608 XBD=838 XBD=1006 XBD=1311 XHG=146 XHG=319 XHG=506 XHG=857YBD=1208 XHG=1025 YBD=1209 YBD=1219 YBD=1219 YBD=1219YHG=1174>now YHG=1175>in-vitro YHG=1175>activity YHG=1175>have YHG=1174>largely YHG=1174>disentangled. been
,
i
i
" XBD=1826 XBD=1994 XBD=2061 XHG=1536 XHG=1847 XHG=2017 XHG=2085 YBD=1254 YBD=1253 YHG=1233>ANTIBACTERIAL YHG=1233>INDICES YHG=1233>OF YHG=1233>SULPHONAMIDES " XBD=2389 XBD=222 XHG=810 XBD=373 XBD=438 XBD=638 XBD=789 XBD=913 XBD=1034 XBD=1250 XBD=1313 XHG=146 XHG=242 XHG=394 XHG=454 XHG=659 XHG=934YBD=1258 XHG=1054 XHG=1270 YBD=1257 YBD=1258 YBD=1258 YBD=1257 YHG=1224>The YHG=1223>effects YHG=1223>of YHG=1224>different YHG=1223>media YHG=1224>have YHG=1211>been YHG=1223>allocated YHG=1226>to
-
" XBD=2567 XBD=1597 XBD=1710 XBD=1835 XBD=1894 XBD=1978 XBD=2072 XBD=2234 XBD=2423 XHG=1420 XHG=1620 XHG=1733 XHG=1858 XHG=1918 XHG=2002 XHG=2095 XHG=2281 XHG=2446 YBD=1317 YBD=1316 YBD=1307 YBD=1309 YBD=1308 YHG=1280>Compiled YHG=1280>from YHG=1281>Wyss YHG=1282>et YHG=1280>a1.4 YHG=1280>and YHG=1279>Wood.3 YHG=1278>Wood’s YHG=1279>values XBD=297 XHG=895 XBD=592 XBD=865 XBD=939 XBD=1096 XBD=1312 XHG=147 XHG=329 XHG=621 XHG=968YBD=1307 XHG=1116 YBD=1318 YBD=1315 YBD=1307 YHG=1272>definite YHG=1274>antagonistic YHG=1272>substances, YHG=1272>of YHG=1273>which YHG=1274>p-amino|>" " XBD=1432 XBD=1484 XBD=1733 XBD=1852 XBD=1991 XBD=2059 XBD=2440 XBD=2513 XBD=2235 XHG=1375 XHG=1448 XHG=1498 XHG=1780 XHG=1867 XHG=2006 XHG=2251 XHG=2456 XHG=2528 XHG=2075 YBD=1356 YBD=1357 YBD=1348 YBD=1347 YBD=1348 YHG=1320>parentheses. YHG=1320>The YHG=1320>figures YHG=1320>for YHG=1320>organisms YHG=1329>are YHG=1320>in YHG=1320>different "" XBD=2566 XBD=326 XBD=379 XBD=467 XBD=681 XBD=788 XBD=967 XBD=1054 XBD=1164 XBD=1313 XHG=147 XHG=347 XHG=399 XHG=488 XHG=702 XHG=843 XHG=989 XHG=1074 XHG=1183 YBD=1368 YBD=1357 YBD=1357 YBD=1357 YBD=1367 YHG=1323>benzoate YHG=1323>is YHG=1323>the YHG=1322>principal YHG=1334>one. YHG=1323>These YHG=1334>are YHG=1334>now YHG=1334>recogXBD=1434 XBD=1548 XBD=1797 XBD=1883 XBD=1963 XBD=2129 XBD=2184 XBD=2350 XBD=2565 XHG=1374 XHG=1453 XHG=1568 XHG=1818 XHG=1900 XHG=1982 XHG=2147 XHG=2204 XHG=2369 YBD=1387 YBD=1397 YBD=1396 YBD=1388 YHG=1360>the YHG=1360>main YHG=1360>comparable, YHG=1360>but YHG=1363>not YHG=1360>entirely YHG=1369>so YHG=1360>because YHG=1360>conditions "" XBD=1315 XBD=250 XBD=346 XBD=416 XBD=682 XBD=858 XBD=975 XBD=1047 XBD=1218 XHG=148 XHG=277 XHG=374 XHG=445 XHG=710 XHG=1003 XHG=1075 XHG=1245 YBD=1407 YBD=1406 YBD=1407 YBD=1417 YBD=1406 YHG=1372>nised YHG=1375>not YHG=1384>as YHG=1376>extraneous YHG=1372>factors YHG=1375>sent YHG=1376>to YHG=1372>plague YHG=1372>the XBD=1415XHG=888 XBD=1563 XBD=1665 XBD=1744 XBD=1899 XHG=1375 XHG=1428 XHG=1577 XHG=1680 XHG=1759 YBD=1435 YBD=1427 YBD=1428 YHG=1399>of YHG=1400>growth YHG=1408>were YHG=1402>not YHG=1399>inform.
" XBD=1320 XBD=469 XHG=653 XBD=567 XBD=634 XBD=936 XBD=1002 XBD=1094 XBD=1252 XHG=149 XHG=494 XHG=591 XHG=958YBD=1460 XHG=1025 XHG=1118 XHG=1276 YBD=1467 YBD=1456 YBD=1456 YBD=1456YHG=1421>fundamental YHG=1421>chemotherapist YHG=1422>but YHG=1434>as YHG=1425>to YHG=1422>the YHG=1423>action YHG=1421>of XBD=211 XHG=913 XBD=375 XBD=511 XBD=873 XBD=979 XBD=1315 XHG=149 XHG=248 XHG=429 XHG=552 XHG=1019YBD=1505 YBD=1515 YBD=1504 YBD=1516 YBD=1505YHG=1483>are YHG=1471>the YHG=1471>drugs. YHG=1471>The YHG=1471>sulphonamides YHG=1471>bacteriostatic "" XBD=2560 XBD=1675 XBD=1827 XBD=1903 XBD=2109 XBD=2186 XHG=1378 XHG=1710 XHG=1861 XHG=1938 XHG=2142 XHG=2222 YBD=1529 YBD=1519 YBD=1530 YHG=1483>sulphadiazine YHG=1484>equal YHG=1486>in YHG=1485>activity YHG=1487>to YHG=1484>sulphapyridine, XBD=303 XHG=807 XBD=425 XBD=532 XBD=781 XBD=954 XBD=1022 XBD=1245 XBD=1315 XHG=150 XHG=328 XHG=451 XHG=543 XHG=979YBD=1555 XHG=1048 XHG=1272 YBD=1554 YBD=1558 YBD=1565 YBD=1554 YBD=1554YHG=1520>similar YHG=1520>because YHG=1520>they YHG=1532>are YHG=1520>sufficiently YHG=1521>in YHG=1523>structure YHG=1523>to "" XBD=2561 XBD=1990 XBD=2099 XBD=2237 XBD=2296 XBD=2475 XHG=1847 XHG=2002 XHG=2113 XHG=2254 XHG=2312 XHG=2491 YBD=1579 YBD=1568 YBD=1580 YBD=1569 YHG=1537>2 YHG=1535>with YHG=1534>Wyss YHG=1535>in YHG=1536>putting YHG=1535>the agree XBD=1492 XBD=1626 XBD=1724 XHG=1379 XHG=1510 XHG=1644 YHG=1533>while YHG=1534>RosE YHG=1534>and XBD=504 XHG=856 XBD=599 XBD=734 XBD=810 XBD=960 XBD=1080 XBD=1317 XHG=147 XHG=556 XHG=644 XHG=777 XHG=1011YBD=1604 XHG=1133 YBD=1615 YBD=1604YHG=1569>from YHG=1570>p-aminobenzoate YHG=1573>to YHG=1574>oust YHG=1571>it YHG=1570>the YHG=1569>essential "" XBD=2563 XBD=1550 XBD=1612 XBD=1932 XBD=2069 XBD=2130 XBD=2240 XBD=2302 XHG=1379 XHG=1569 XHG=1636 XHG=1951 XHG=2086 XHG=2148 XHG=2259 XHG=2317 YBD=1629 YBD=1618 YBD=1619 YBD=1630 YHG=1584>activity YHG=1583>of YHG=1583>sulphadiazine YHG=1584>equal YHG=1587>to YHG=1584>that YHG=1584>of YHG=1584>sulphathia"" XBD=1317 XBD=325 XBD=547 XBD=714 XBD=823 XBD=907 XBD=1055 XHG=152 XHG=365 XHG=587 XHG=753 XHG=962 XHG=1095 YBD=1664 YBD=1653 YBD=1653 YBD=1654 YHG=1619>bacterial YHG=1631>enzymes YHG=1620>which YHG=1632>use YHG=1620>This YHG=1619>functional XBD=1474XHG=862 XBD=1584 XBD=1680 XBD=1999 XBD=2179 XBD=2327 XBD=2474 XBD=2564 XHG=1379YBD=1654 XHG=1530 XHG=1610 XHG=1712 XHG=2026 XHG=2199 XHG=2355 XHG=2494 YBD=1679YHG=1621>it. YBD=1668 YHG=1633>zole. YHG=1633>Of YHG=1633>the YHG=1630>conditions YHG=1633>growth YHG=1634>which YHG=1634>affect YHG=1634>the ’of "" XBD=1317 XBD=393 XBD=461 XBD=859 XBD=956 XBD=1071 XBD=1195 XHG=152 XHG=418 XHG=484 XHG=884 XHG=981 XHG=1096 XHG=1219 YBD=1713 YBD=1703 YBD=1703 YBD=1702 YHG=1668>relationship YHG=1672>to YHG=1669>p-aminobenzoate YHG=1670>has YHG=1680>now YHG=1669>been XBD=1811 XHG=2519 XBD=1920 XBD=2080 XBD=2108 XBD=2238 XBD=2402 XBD=2493 XBD=2563 XHG=1379 YBD=1718 XHG=1839 XHG=1947 XHG=2094 XHG=2135 XHG=2265 XHG=2423 YBD=1724 YHG=1669>used YBD=1704 YBD=1717 YBD=1729 YHG=1680>indices,JScHMELKES YHG=1683>and YHG=1684>others YHG=1686>5 YHG=1683>have YHG=1683>shown YHG=1684>pH YHG=1687>to "" XBD=1317 XBD=188 XBD=304 XBD=550 XBD=722 XBD=800 XBD=904 XBD=1137 XBD=1217 XHG=149 XHG=221 XHG=337 XHG=586 XHG=757 XHG=940 XHG=1173 XHG=1247 YBD=1763 YBD=1752 YBD=1752 YHG=1719>give YHG=1718>numerical YHG=1718>values YHG=1721>to YHG=1718>activities YHG=1717>of YHG=1718>the XBD=1428XHG=835 XBD=1487 XBD=1776 XBD=2045 XBD=2139 XBD=2253 XBD=2565 XHG=1379YBD=1752 XHG=1443 XHG=1498 XHG=1786 XHG=2059 XHG=2150 XHG=2265 YBD=1778YHG=1718>the YBD=1767 YHG=1732>be YHG=1733>of YHG=1733>fundamental YHG=1734>importance, YHG=1733>and YHG=1733>have YHG=1733>demonstrated "" XBD=1316 XBD=321 XBD=688 XBD=826 XBD=963 XBD=1089 XBD=1254 XHG=151 XHG=357 XHG=744 XHG=861 XHG=1001 XHG=1127 XHG=1291 YBD=1813 YBD=1802 YBD=1814 YBD=1802 YBD=1803 YHG=1767>different YHG=1767>sulphonamides. YHG=1768>The YHG=1769>ratio YHG=1768>S/P, YHG=1768>where XBD=1472 XHG=2467 XBD=1556 XBD=1745 XBD=1803 XBD=1991 XBD=2051 XBD=2115 XBD=2451 XBD=2564 XHG=1379 YBD=1817 XHG=1486 XHG=1571 XHG=1760 XHG=1817 XHG=2006 XHG=2062 XHG=2130 YBD=1828 YHG=1768>S YHG=1782>that YHG=1783>the YHG=1783>increase YHG=1784>in YHG=1786>potency YHG=1782>of YHG=1782>all YHG=1782>sulphonamides YHG=1783>with "" XBD=1317 XBD=355 XBD=468 XBD=814 XBD=904 XBD=969 XHG=149 XHG=400 XHG=515 XHG=860 XHG=946 XHG=1016 YBD=1863 YBD=1852 YBD=1851 YBD=1863 YHG=1821>represents YHG=1818>the YHG=1819>concentration YHG=1817>of YHG=1830>a XBD=1554 XHG=2471 XBD=1617 XBD=1707 XBD=1761 XBD=1825 XBD=1989 XBD=2107 XBD=2242 XBD=2450 XBD=2564 XHG=1380 YBD=1867 XHG=1575 XHG=1638 XHG=1728 XHG=1782 XHG=1846 XHG=2009 XHG=2129 XHG=2264 YBD=1878 YHG=1817>sulphonamide YHG=1832>increase YHG=1833>pH YHG=1834>is YHG=1833>in YHG=1832>accord YHG=1833>with YHG=1832>other YHG=1832>evidence YHG=1833>that "" XBD=1318 XBD=343 XBD=416 XBD=781 XBD=864 XBD=1063 XBD=1123 XHG=152 XHG=357 XHG=432 XHG=879 XHG=1078 XHG=1134 YBD=1912 YBD=1902 YBD=1913 YBD=1901 YHG=1879>necessary YHG=1866>for YHG=1867>bacteriostasis YHG=1879>presence YHG=1867>of YHG=1867>different in XBD=1449XHG=795 XBD=1608 XBD=1880 XBD=1995 XBD=2064 XBD=2107 XBD=2433 XBD=2490 XBD=2566 XHG=1379YBD=1901 XHG=1474 XHG=1630 XHG=1903 XHG=2019 XHG=2083 XHG=2132 XHG=2456 XHG=2513 YBD=1917YHG=1868>the YBD=1928 YBD=1916 YHG=1882>the YHG=1882>actual YHG=1882>functioning YHG=1885>part YHG=1882>of YHG=1895>a YHG=1881>sulphonamide YHG=1883>is YHG=1894>an "" XBD=1317 XBD=454 XBD=509 XBD=576 XBD=980 XBD=1037 XBD=1204 XHG=153 XHG=477 XHG=532 XHG=592 XHG=1004 XHG=1059 XHG=1227 YBD=1952 YBD=1951 YBD=1962 YBD=1950 YBD=1951 YHG=1918>concentrations YHG=1917>P YHG=1917>of YHG=1917>p-aminobenzoate, YHG=1918>is YHG=1917>almost YHG=1928>conXBD=1513 XHG=2432 XBD=1617 XBD=1825 XBD=1885 XBD=2080 XBD=2418 XBD=2564 XHG=1381 YBD=1966 XHG=1567 XHG=1633 XHG=1841 XHG=1897 XHG=2096 YBD=1967 YHG=1932>whose YBD=1978 YHG=1933>anion. YHG=1932>In YHG=1932>solutions YHG=1932>of YHG=1932>different YHG=1932>sulphonamides "" XBD=1317 XBD=251 XBD=325 XBD=365 XBD=498 XBD=817 XBD=915 XBD=955 XBD=1089 XHG=152 XHG=267 XHG=343 XHG=382 XHG=515 XHG=835 XHG=972 XHG=1107 YBD=2012 YBD=2012 YBD=2012 YHG=1970>stant YHG=1966>for YHG=1968>given YHG=1966>sulphonamide YHG=1967>and YHG=1967>given YHG=1968>organism, XBD=1564XHG=932 XBD=1620 XBD=1831 XBD=1897 XBD=2009 XBD=2150 XBD=2356 XBD=2449 XBD=2563 XHG=1382YBD=2001 XHG=1587 XHG=1644 XHG=1853 XHG=1921 XHG=2033 XHG=2173 XHG=2380 XHG=2475 YBD=2026YHG=1979>a YBD=2027 YBD=2016 YBD=2015 YHG=1982>strength YHG=1983>is YHG=1981>adjusted YHG=1985>to YHG=1983>give YHG=1982>equal YHG=1982>activity, YHG=1982>the YHG=1992>con"" XBD=1323 XBD=225 XBD=271 XBD=309 XBD=506 XBD=570 XBD=653 XBD=813 XBD=1108 XBD=1260 XHG=153 XHG=240 XHG=290 XHG=329 XHG=526 XHG=584 XHG=672 XHG=830 XHG=1127 XHG=1280 YBD=2050 YBD=2051 YBD=2062 YBD=2051 YBD=2050 YBD=2051 YHG=2014>and YHG=2017>is YHG=2028>a YHG=2028>measure YHG=2016>of YHG=2016>the YHG=2016>purely YHG=2016>antibacterial YHG=2017>action XBD=1626 XHG=2415 XBD=1690 XBD=1843 XBD=1928 XBD=1991 XBD=2075 XBD=2202 XBD=2337 XBD=2400 XBD=2564 XHG=1383 YBD=2076 XHG=1646 XHG=1704 XHG=1862 XHG=1947 XHG=2005 XHG=2094 XHG=2221 XHG=2356 YBD=2066 YHG=2016>of YHG=2032>centrations YHG=2033>anions YHG=2043>are YHG=2032>the YHG=2043>same YHG=2031>order YHG=2031>of YHG=2032>magni" XBD=1320 XBD=215 XHG=657 XBD=334 XBD=470 XBD=641 XBD=738 XBD=1000 XBD=1060 XBD=1147 XHG=154 XHG=230 XHG=388 XHG=486 XHG=752YBD=2100 XHG=1016 XHG=1078 XHG=1164 YBD=2101 YBD=2112 YBD=2101 YBD=2107YHG=2066>this YBD=2100 YHG=2067>the YHG=2066>drug. YHG=2066>The YHG=2065>smaller YHG=2066>ratio-that YHG=2067>is, YHG=2066>the YHG=2066>smaller " XBD=1321 XBD=216 XHG=818 XBD=424 XBD=494 XBD=615 XBD=793 XBD=880 XHG=155 XHG=242 XHG=450 XHG=516 XHG=641 XHG=905YBD=2150 YBD=2161 YBD=2150YHG=2115>for YHG=2117>the YHG=2117>quantity YHG=2115>of YHG=2116>drug YHG=2115>needed YHG=2116>bacteriostasis-the " XBD=1321 XBD=252 XHG=893 XBD=425 XBD=538 XBD=628 XBD=750 XBD=873 XBD=955 XBD=1045 XBD=1216 XBD=1270 XHG=158 XHG=273 XHG=445 XHG=559 XHG=650 XHG=770 XHG=975YBD=2200 XHG=1065 XHG=1236 XHG=1289 YBD=2210 YBD=2199 YBD=2210YHG=2165>for YBD=2199 YHG=2177>more YHG=2165>affinity YHG=2165>does YHG=2166>the YHG=2165>drug YHG=2165>have YHG=2165>the YHG=2168>system YHG=2166>it YHG=2166>is " XBD=1323 XBD=374 XHG=835 XBD=532 XBD=680 XBD=810 XBD=925 XBD=1051 XHG=157 XHG=428 XHG=557 XHG=706 XHG=951YBD=2250 XHG=1076 YBD=2260 YBD=2249 YBD=2249 YBD=2249YHG=2227>now YHG=2216>disturbing. YHG=2215>Such YHG=2216>ratios YHG=2215>have YHG=2215>been YHG=2215>determined " XBD=1324 XBD=209 XHG=773 XBD=386 XBD=633 XBD=744 XBD=919 XBD=1062 XBD=1193 XHG=157 XHG=235 XHG=417 XHG=663 XHG=964YBD=2310 XHG=1090 XHG=1224 YBD=2300 YBD=2299 YBD=2309 YBD=2299YHG=2265>drugs YHG=2264>for YHG=2266>various YHG=2265>organisms YHG=2264>and YHG=2264>they YHG=2265>have; YHG=2265>been "" XBD=1322 XBD=311 XBD=375 XBD=441 XBD=942 XBD=1008 XBD=1074 XHG=156 XHG=332 XHG=399 XHG=465 XHG=965 XHG=1032 XHG=1097 YBD=2349 YBD=2348 YBD=2356 YBD=2348 YBD=2348 YBD=2359 YHG=2315>referred YHG=2318>to YHG=2326>as YHG=2314>antibacterial’indices,l YHG=2325>or YHG=2325>as XBD=1498 XHG=2498 XBD=1725 XBD=1836 XBD=2161 XBD=2353 XBD=2445 XBD=2567 XHG=1385 YBD=2371 XHG=1546 XHG=1766 XHG=1883 XHG=2205 XHG=2401 YBD=2373 YHG=2315>measuring YBD=2374 YBD=2372 YHG=2350>ences YHG=2339>between YHG=2339>the YHG=2338>antibacterial YHG=2338>indices YHG=2337>of YHG=2337>the "" XBD=1322 XBD=436 XBD=671 XBD=785 XBD=921 XBD=1186 XHG=158 XHG=470 XHG=705 XHG=817 XHG=953 XHG=1219 YBD=2399 YBD=2409 YBD=2398 YBD=2409 YBD=2398 YHG=2365>bacteriostatic YHG=2366>potency,2 YHG=2364>and YHG=2364>their YHG=2364>reciprocals YHG=2364>have XBD=1706 XBD=1796 XBD=1844 XBD=1985 XBD=2207 XBD=2387 XHG=1385 XHG=1735 XHG=1820 XHG=1867 XHG=2008 XHG=2237 XHG=2411 YBD=2434 YBD=2423 YBD=2422 YBD=2433 YBD=2432 YHG=2388>sulphonamides YHG=2388>for YHG=2400>a YHG=2390>given YHG=2389>organism YHG=2387>largely YHG=2387>depend "" XBD=2567 XBD=245 XBD=412 XBD=757 XBD=1043 XBD=1208 XBD=1321 XHG=156 XHG=293 XHG=461 XHG=808 XHG=1095 XHG=1255 YBD=2449 YBD=2448 YBD=2448 YBD=2458 YBD=2447 YHG=2414>been YHG=2414>called YHG=2414>bacteriostatic YHG=2416>constants.3 YHG=2413>They XBD=1437 XHG=2140 XBD=1528 XBD=1719 XBD=1788 XBD=1927 XBD=1991 XBD=2117 XBD=2345 XHG=1385 YBD=2472 XHG=1459 XHG=1552 XHG=1743 XHG=1807 XHG=1949 XHG=2012 YBD=2471 YHG=2425>are YHG=2449>on YHG=2439>the YHG=2441>amount YHG=2438>of YHG=2439>anion YHG=2439>in YHG=2438>their YHG=2437>solutions. "" XBD=1316 XBD=325 XBD=487 XBD=546 XBD=757 XBD=1164 XHG=156 XHG=337 XHG=504 XHG=563 XHG=776 XHG=1183 YBD=2508 YBD=2498 YBD=2497 YBD=2508 YBD=2504 YHG=2463>formally YHG=2463>related YHG=2467>to YHG=2462>Ehrlich’s YHG=2463>chemotherapeutic YHG=2462>index, XBD=1486 XBD=1597 XBD=1765 XBD=1861 XBD=1935 XBD=2281 XBD=2434 XHG=1436 XHG=1513 XHG=1611 XHG=1792 XHG=1890 XHG=1959 XHG=2309 XHG=2460 YBD=2522 YBD=2534 YBD=2521 YBD=2532 YBD=2520 YHG=2488>In YHG=2488>the YHG=2487>clinical YHG=2499>use YHG=2486>of YHG=2487>sulphonamides YHG=2498>many YHG=2497>more "" XBD=2569 XBD=296 XBD=393 XBD=646 XBD=706 XBD=791 XBD=1097 XBD=1213 XBD=1322 XHG=156 XHG=326 XHG=427 XHG=673 XHG=735 XHG=820 XHG=1133 XHG=1248 YBD=2558 YBD=2547 YBD=2546 YBD=2557 YBD=2558 YBD=2547 YBD=2546 YHG=2513>though YHG=2513>the YHG=2514>connexion YHG=2513>is YHG=2512>by YHG=2513>computation YHG=2513>and YHG=2517>not XBD=1814 XBD=1909 XBD=2177 XBD=2273 XBD=2570 XHG=1384 XHG=1866 XHG=1961 XHG=2230 XHG=2325 YBD=2571 YBD=2570 YBD=2581 YHG=2525>factors-differences YHG=2536>solubility, YHG=2537>in YHG=2536>absorption, experiment. "" XBD=287 XBD=219 XHG=157 XHG=236 YBD=2608 YBD=2607 YHG=2568>yet YHG=2564>by XBD=1659 XBD=1773 XBD=2007 XBD=2096 XBD=2198 XBD=2323 XBD=2440 XBD=2573 XHG=1386 XHG=1692 XHG=1806 XHG=2042 XHG=2128 XHG=2231 XHG=2357 XHG=2472 YBD=2630 YBD=2621 YBD=2620 YHG=2587>detoxication YHG=2586>and YHG=2586>excretion YHG=2586>by YHG=2586>the YHG=2586>host YHG=2585>and YHG=2597>even "" XBD=1321 XBD=278 XBD=432 XBD=494 XBD=632 XBD=733 XBD=911 XBD=1100 XBD=1183 XHG=202 XHG=294 XHG=451 XHG=508 XHG=652 XHG=750 XHG=1059 XHG=1114 XHG=1200 YBD=2647 YBD=2646 YBD=2652 YBD=2646 YBD=2653 YHG=2613>The YHG=2612>results YHG=2612>of YHG=2613>WYSS YHG=2611>and YHG=2611>others,4 YHG=2613>in YHG=2611>the YHG=2611>table, given XBD=1427 XBD=1697 XBD=1797 XBD=2063 XBD=2133 XBD=2277 XBD=2381 XBD=2573 XHG=1384 XHG=1446 XHG=1717 XHG=1818 XHG=2084 XHG=2152 XHG=2296 XHG=2403 YBD=2671 YBD=2681 YBD=2669 YBD=2670 YHG=2637>in YHG=2636>availability YHG=2635>and YHG=2638>cost-must YHG=2635>be YHG=2635>taken YHG=2636>into YHG=2639>account "" XBD=1322 XBD=315 XBD=423 XBD=484 XBD=602 XBD=951 XBD=1054 XBD=1173 XHG=158 XHG=333 XHG=440 XHG=503 XHG=621 XHG=971 XHG=1072 XHG=1192 YBD=2696 YBD=2697 YBD=2707 YBD=2706 YBD=2695 YBD=2696 YHG=2663>indicate YHG=2663>that YHG=2665>to YHG=2662>both YHG=2661>sulphanilamide YHG=2662>(the YHG=2660>least YHG=2663>active XBD=1427 XBD=1649 XBD=1754 XBD=1890 XBD=2014 XBD=2182 XBD=2261 XBD=2321 XHG=1385 XHG=1463 XHG=1684 XHG=1790 XHG=1926 XHG=2051 XHG=2216 XHG=2297 XHG=2356 YBD=2730 YBD=2720 YBD=2719 YBD=2731 YHG=2687>in YHG=2686>choosing YHG=2685>the YHG=2685>drug YHG=2684>best YHG=2685>suited YHG=2688>to YHG=2697>a YHG=2685>particular "" XBD=2572 XBD=258 XBD=382 XBD=738 XBD=868 XBD=1017 XBD=1206 XBD=1322 XHG=156 XHG=304 XHG=425 XHG=784 XHG=912 XHG=1062 XHG=1252 YBD=2746 YBD=2757 YBD=2756 YBD=2745 YBD=2756 YBD=2745 YHG=2712>drug) YHG=2712>and YHG=2711>sulphathiazole YHG=2711>(the YHG=2714>most YHG=2712>active) YHG=2711>the XBD=1569 XBD=1700 XBD=1923 XBD=2012 XBD=2185 XBD=2572 XHG=1386 XHG=1622 XHG=1730 XHG=1955 XHG=2045 XHG=2216 YBD=2776 YBD=2769 YBD=2770 YBD=2781 YHG=2747>purpose. YHG=2735>For YHG=2735>instance, YHG=2747>we YHG=2734>choose YHG=2735>sulphaguanidine "" XBD=1324 XBD=459 XBD=523 XBD=657 XBD=894 XBD=1012 XBD=1072 XHG=157 XHG=479 XHG=537 XHG=676 XHG=911 XHG=1030 XHG=1090 YBD=2796 YBD=2795 YBD=2806 YBD=2794 YBD=2794 YBD=2806 YHG=2761>susceptibilities YHG=2761>of YHG=2772>seven YHG=2761>organisms YHG=2772>were YHG=2761>in YHG=2760>practically XBD=1429 XBD=1596 XBD=1828 XBD=2072 XBD=2292 XBD=2376 XBD=2573 XHG=1385 XHG=1457 XHG=1622 XHG=1854 XHG=2099 XHG=2323 XHG=2408 YBD=2819 YBD=2829 YBD=2831 YBD=2820 YHG=2788>to YHG=2785>attack YHG=2784>intestinal YHG=2785>organisms YHG=2785>although YHG=2787>its YHG=2786>in-vitro "" XBD=1323 XBD=220 XBD=337 XBD=492 XBD=594 XBD=713 XBD=909 XBD=994 XBD=1160 XBD=1237 XHG=159 XHG=236 XHG=356 XHG=524 XHG=609 XHG=731 XHG=925 XHG=1011 XHG=1176 XHG=1253 YBD=2853 YBD=2845 YBD=2844 YBD=2844 YHG=2822>same YHG=2811>order YHG=2811>the YHG=2811>ratio YHG=2810>between YHG=2810>the YHG=2810>indices YHG=2810>for YHG=2811>the ; XBD=1558 XBD=1611 XBD=1721 XBD=1841 XBD=1931 XBD=2062 XBD=2205 XBD=2271 XBD=2361 XBD=2509 XBD=2577 XHG=1387 XHG=1579 XHG=1633 XHG=1778 XHG=1861 XHG=1948 XHG=2083 XHG=2228 XHG=2291 XHG=2377 XHG=2532 YBD=2879 YBD=2868 YBD=2876 YBD=2870 YBD=2869 YHG=2835>activity YHG=2835>is YHG=2834>low. YHG=2833>On YHG=2834>the YHG=2834>other YHG=2834>hand, YHG=2835>in YHG=2836>the YHG=2836>choice YHG=2834>of "" XBD=1321 XBD=230 XBD=367 XBD=471 XBD=613 XBD=708 XBD=841 XBD=963 XBD=1085 XHG=158 XHG=253 XHG=392 XHG=495 XHG=639 XHG=734 XHG=866 XHG=988 XHG=1112 YBD=2904 YBD=2894 YBD=2893 YBD=2893 YBD=2904 YHG=2862>two YHG=2860>drugs YHG=2853>was YHG=2860>much YHG=2860>the YHG=2871>same YHG=2859>with YHG=2859>each YHG=2860>organism. XBD=1701 XBD=1776 XBD=2110 XBD=2204 XBD=2352 XHG=1388 XHG=1714 XHG=1790 XHG=2124 XHG=2217 XHG=2363 YBD=2929 YBD=2917 YBD=2928 YBD=2918 YBD=2919 YBD=2920 YHG=2883>sulphathiazole YHG=2882>for YHG=2883>staphylococcal YHG=2884>and YHG=2884>mixed YHG=2884>infections "" XBD=2575 XBD=269 XBD=321 XBD=482 XBD=577 XBD=760 XBD=892 XBD=980 XBD=1050 XBD=1137 XBD=1324 XHG=157 XHG=281 XHG=337 XHG=497 XHG=594 XHG=777 XHG=909 XHG=998 XHG=1066 XHG=1155 YBD=2951 YBD=2944 YBD=2954 YBD=2943 YBD=2943 YBD=2943 YBD=2954 YHG=2908>Thus, YHG=2921>as YHG=2909>GREEN YHG=2909>and YHG=2909>PARKIN YHG=2910>point YHG=2911>out YHG=2920>on YHG=2920>our YHG=2910>opening XBD=1667 XBD=1819 XBD=1882 XBD=1981 XBD=2237 XBD=2573 XHG=1388 XHG=1696 XHG=1848 XHG=1912 XHG=2013 XHG=2270 YBD=2968 YBD=2967 YBD=2980 YBD=2969 YHG=2933>antibacterial YHG=2932>index YHG=2934>is YHG=2933>the YHG=2935>overriding YHG=2934>consideration. "" XBD=1323 XBD=260 XBD=310 XBD=358 XBD=399 XBD=561 XBD=621 XBD=751 XBD=860 XBD=896 XBD=1125 XHG=160 XHG=279 XHG=326 XHG=376 XHG=416 XHG=578 XHG=633 XHG=768 XHG=873 XHG=910 XHG=1138 YBD=3002 YBD=3003 YBD=2993 YBD=2992 YBD=3003 YBD=3003 YHG=2970>page, YHG=2960>it YHG=2959>is YHG=2958>fallacy YHG=2962>to YHG=2958>think YHG=2959>that YHG=2970>a YHG=2958>particular YHG=2958>sulphonXBD=1497 XBD=1711 XBD=1882 XBD=1944 XBD=2069 XBD=2237 XBD=2413 XBD=2486 XBD=2574 XHG=1389 XHG=1517 XHG=1731 XHG=1902 XHG=1963 XHG=2090 XHG=2256 XHG=2433 XHG=2504 YBD=3027 YBD=3016 YBD=3018 YHG=2983>Thus YHG=2982>although YHG=2982>studies YHG=2984>in YHG=2984>vitro YHG=2987>cannot YHG=2983>include YHG=2984>all YHG=2985>the "" XBD=1325 XBD=278 XBD=326 XBD=500 XBD=579 XBD=621 XBD=855 XBD=1102 XBD=1204 XHG=159 XHG=296 XHG=348 XHG=517 XHG=598 XHG=638 XHG=879 XHG=1134 XHG=1219 YBD=3040 YBD=3042 YBD=3052 YBD=3052 YBD=3041 YHG=3007>amide YHG=3008>is YHG=3008>specific YHG=3008>for YHG=3020>a YHG=3008>particular YHG=3008>organism YHG=3007>the YHG=3010>most : XBD=1536 XBD=1692 XBD=1831 XBD=1912 XBD=1995 XBD=2264 XBD=2344 XBD=2575 XHG=1388 XHG=1563 XHG=1728 XHG=1867 XHG=1947 XHG=2035 XHG=2302 XHG=2383 YBD=3068 YBD=3066 YBD=3078 YHG=3031>factors YHG=3032>which YHG=3032>have YHG=3034>to YHG=3032>be YHG=3032>considered YHG=3034>in YHG=3034>practical "" XBD=1326 XBD=278 XBD=389 XBD=558 XBD=647 XBD=860 XBD=909 XBD=1122 XBD=1205 XHG=159 XHG=294 XHG=403 XHG=574 XHG=663 XHG=876 XHG=924 XHG=1135 XHG=1219 YBD=3089 YBD=3100 YBD=3101 YBD=3102 YBD=3091 YBD=3101 YBD=3090 YBD=3091 YHG=3057>active YHG=3056>drug YHG=3058>against YHG=3068>one YHG=3058>organism YHG=3057>is YHG=3056>normally YHG=3057>the YHG=3059>most XBD=1715 XBD=1840 XBD=1992 XBD=2121 XBD=2342 XBD=2473 XHG=1389 XHG=1770 XHG=1895 XHG=2051 XHG=2182 XHG=2404 XHG=2536 YBD=3126 YBD=3116 YBD=3127 YBD=3117 YBD=3118 YHG=3081>chemotherapy, YHG=3084>yet YHG=3082>with YHG=3083>the YHG=3085>present YHG=3094>use YHG=3083>of "" XBD=2581 XBD=278 XBD=457 XBD=549 XBD=696 XBD=895 XBD=1038 XBD=1108 XBD=1326 XHG=159 XHG=306 XHG=487 XHG=632 XHG=724 XHG=924 XHG=1066 XHG=1136 YBD=3138 YBD=3150 YBD=3140 YBD=3151 YBD=3140 YBD=3151 YHG=3105>active YHG=3106>against YHG=3105>all. YHG=3105>All YHG=3106>workers YHG=3117>agree YHG=3107>in YHG=3105>principle XBD=1546 XBD=1720 XBD=1854 XBD=1955 XBD=2125 XBD=2206 XBD=2358 XBD=2577 XHG=1389 XHG=1589 XHG=1754 XHG=1889 XHG=1990 XHG=2159 XHG=2239 XHG=2392 YBD=3166 YBD=3177 YBD=3165 YBD=3176 YBD=3167 YHG=3130>defined YHG=3131>media YHG=3131>they YHG=3143>are YHG=3133>giving YHG=3143>us YHG=3131>fairly YHG=3136>accurate "|>" XBD=372 XBD=530 XBD=624 XBD=732 XBD=936 XBD=1171 XBD=1326 XBD=247 XHG=265 XHG=389 XHG=550 XHG=643 XHG=752 XHG=954 XHG=1189 XHG=161 YBD=3187 YBD=3199 YBD=3189 YBD=3189 YBD=3187 YBD=3189 YHG=3154>these YHG=3155>results YHG=3155>but YHG=3156>give YHG=3155>different YHG=3155>numerical YHG=3154>with YHG=3154>values "" XBD=2579 XBD=1650 XBD=1751 XBD=1916 XBD=2162 XBD=2346 XHG=1389 XHG=1707 XHG=1796 XHG=1971 XHG=2217 XHG=2418 YBD=3225 YBD=3227 YBD=3215 YBD=3216 YHG=3179>information YHG=3180>of YHG=3184>great YHG=3181>practical YHG=3180>value. YHG=3181>Animal XBD=216 XBD=296 XBD=586 XBD=764 XBD=931 XBD=1142 XBD=1327 XHG=161 XHG=231 XHG=313 XHG=603 XHG=785 XHG=950 XHG=1159 YBD=3235 YBD=3236 YBD=3238 YBD=3245 YBD=3239 YBD=3249 YBD=3238 YHG=3201>for YHG=3203>the YHG=3204>antibacterial YHG=3204>indices, YHG=3204>almost YHG=3204>certainly YHG=3204>because "" XBD=2578 XBD=1651 XBD=1727 XBD=1882 XBD=1976 XBD=2302 XHG=1391 XHG=1694 XHG=1773 XHG=1927 XHG=2020 XHG=2350 YBD=3275 YBD=3264 YBD=3266 YBD=3271 YBD=3265 YHG=3230>experiment, YHG=3231>it YHG=3231>must YHG=3230>be YHG=3229>remembered, YHG=3231>introduces XBD=249 XBD=380 XBD=575 XBD=813 XBD=872 XBD=1035 XBD=1130 XBD=1328 XHG=159 XHG=262 XHG=394 XHG=591 XHG=827 XHG=878 XHG=1049 XHG=1143 YBD=3296 YBD=3297 YBD=3287 YBD=3288 YBD=3299 YBD=3288 YHG=3251>they YHG=3252>adopt YHG=3253>different YHG=3253>conditions YHG=3253>of YHG=3254>growth YHG=3254>and " XBD=2580 XBD=1478 XHG=2427 XBD=1591 XBD=1822 XBD=1998 XBD=2071 XBD=2171 XBD=2326 XBD=2400 XHG=1391 YBD=3314 XHG=1509 XHG=1619 XHG=1851 XHG=2028 XHG=2102 XHG=2203 XHG=2356 YBD=3315 YHG=3253>different YBD=3313 YBD=3322 YHG=3290>new YHG=3280>and YHG=3280>unknown YHG=3279>factors YHG=3283>to YHG=3280>the YHG=3279>study YHG=3280>of YHG=3281>human
" XBD=2569 |>" XBD=1510 XBD=1603 XBD=1660 XBD=1924 XBD=2010 XBD=2216 XBD=2409XHG=2440 XHG=1384 XHG=1562 XHG=1627 XHG=1685 XHG=1941 XHG=2035 XHG=2231YBD=2169 YBD=2182 YBD=2170 YBD=2181 YBD=2205YHG=2134>which YHG=2135>tude.6 YHG=2136>It YHG=2136>is YHG=2136>apparently YHG=2136>the YHG=2148>group YHG=2099>S"XBD=2567 XBD=1646 XBD=1865 XBD=1952 XBD=2071 XBD=2281 XBD=2423 XBD=1808XHG=2437 XHG=1384 XHG=1822 XHG=1883 XHG=1971 XHG=2088 XHG=2315 XHG=1663YBD=2268 YBD=2269 YBD=2280 YBD=2320YHG=2233>differYHG=2234>simulates YHG=2238>at YHG=2235>the YHG=2235>drug YHG=2237>receptor. YHG=2234>Thus YHG=2195>C( 0- -
Fox
0 B0-
0
B0-
C5
1. McIlwain, H. Brit. J. exp. Path. 1942, 23, 95. " XBD=1614 XHG=1390 YBD=3363 YHG=3328>infections.
2. Rose, H. M. and Fox, C. L. jun. Science, 1942, 95, 412. 3. Wood, W. B. jun. J. exp. Med. 1942, 75, 369. 4. Wyss, O., Grunbaugh, K. K. and Schmelkes, F. C. Proc. Soc. exp. Biol., N.Y. 1942, 49, 618.
Schmelkes, F. C., Wyss, O., Marks, H. C., Ludwig, B. J. and Strandskov, F. B. Proc. Soc. exp. Biol., N.Y. 1942, 50, 145. 6. Fox, C. L. jun. and Rose, H. M. Ibid, 1942, 50, 142.
5.
" XBD=1526 XBD=1622 XBD=1976 XBD=2138 XBD=2313 XBD=2445 XHG=1371 XHG=1578 XHG=1669 XHG=2030 XHG=2189 XHG=2365 XHG=2495 YBD=222 YBD=221 YHG=189>criteria YHG=187>of YHG=188>bacteriostasis. YHG=187>Thus YHG=187>WYSS YHG=187>and YHG=187>his " XBD=2556 XBD=342 XHG=744 XBD=422 XBD=637 XBD=722 XBD=957 XBD=1060 XBD=1142 XBD=1309 XHG=138 XHG=364 XHG=445 XHG=661 XHG=980YBD=233 XHG=1081 XHG=1164 YBD=223 YBD=232 YBD=222 YBD=221 YBD=221YHG=189>happiness YBD=222 YHG=189>determine YHG=189>his YHG=188>stability, YHG=188>his YHG=188>and YHG=188>his YHG=188>useful-
" " " " " " " "
XBD=2555XHG=729 XBD=231 XBD=363 XBD=615 XBD=696 XBD=863 XBD=1092 XBD=1206 XBD=1311 XBD=1587 XBD=1810 XBD=1905 XBD=2124 XBD=2197 XBD=2319 XHG=139 XHG=284 XHG=398 XHG=652 XHG=902YBD=277 XHG=1125 XHG=1241 XHG=1370 XHG=1616 XHG=1836 XHG=1935 XHG=2152 XHG=2220 XHG=2347 YBD=272 YBD=282 YBD=271 YBD=281 YBD=270YHG=237>death, YBD=271 YBD=282 YHG=249>ness. YHG=238>The YHG=238>proximity YHG=236>of YHG=236>hardship YHG=237>and YHG=237>colleagues YHG=237>observed YHG=237>the YHG=238>quantity YHG=236>of YHG=236>drug YHG=248>necessary XBD=314 XHG=829 XBD=383 XBD=648 XBD=802 XBD=918 XBD=1145 XBD=1198 XBD=1312 XBD=1413 XBD=1585 XBD=1806 XBD=1989 XBD=2060 XBD=2138 XBD=2287 XBD=2361 XBD=2479 XBD=2557 XHG=139 XHG=341 XHG=407 XHG=675 XHG=947YBD=330 XHG=1174 XHG=1225 XHG=1368 XHG=1442 XHG=1616 XHG=1835 XHG=2019 XHG=2093 XHG=2168 XHG=2318 XHG=2391 XHG=2504 YBD=331 YBD=320 YBD=319 YBD=319 YBD=319YHG=286>give YBD=331 YBD=321 YBD=320 YHG=287>ubiquity YHG=286>of YHG=286>destructive YHG=285>forces YHG=286>existence YHG=297>a YHG=297>new YHG=286>reduce YHG=286>bacterial YHG=286>growth YHG=287>in YHG=287>16 YHG=286>hours YHG=288>to YHG=285>half YHG=286>its XBD=323 XHG=803 XBD=425 XBD=528 XBD=644 XBD=713 XBD=779 XBD=940 XBD=1070 XBD=1208 XBD=1264 XBD=1312 XHG=140 XHG=377 XHG=448 XHG=552 XHG=670 XHG=737 XHG=964YBD=367 XHG=1096 XHG=1231 XHG=1289 YBD=379 YBD=368 YBD=374 YBD=374 YBD=367YHG=333>earlier YHG=336>meaning. YHG=335>In YHG=335>this YHG=345>war, YHG=345>as YHG=335>in YHG=345>ones, YHG=334>there YHG=334>is YHG=345>a XBD=2120 XBD=2201 XBD=2293 XBD=2487 XBD=2557 XHG=1933 XHG=2145 XHG=2224 XHG=2319 XHG=2512 YBD=380 YBD=369 YHG=335>3 YHG=335>by YHG=336>the YHG=335>absence YHG=335>of judged XBD=1523 XBD=1727 XHG=1369 XHG=1548 YBD=368 YBD=370 YHG=334>normal YHG=338>amount. XBD=352 XHG=923 XBD=455 XBD=530 XBD=634 XBD=888 XBD=968 XBD=1160 XBD=1313 XHG=140 XHG=385 XHG=489 XHG=565 XHG=670 XHG=1000YBD=416 XHG=1214 YBD=429 YBD=415 YBD=426 YBD=417YHG=382>of YHG=384>significant YHG=382>fall YHG=383>in YHG=382>the YHG=382>frequency YHG=382>suicide. YHG=382>New XBD=1510 XBD=1694 XBD=1866 XBD=1919 XBD=2050 XBD=2161 XBD=2386 XBD=2556 XHG=1372 XHG=1540 XHG=1724 XHG=1897 XHG=1951 XHG=2080 XHG=2189 XHG=2416 YBD=416 YBD=428 YBD=429 YBD=418 YBD=419 YBD=430 YHG=383>visible YHG=384>growth YHG=384>during YHG=386>5 YHG=384>days YHG=384>and YHG=384>therefore YHG=384>placed XBD=232 XHG=799 XBD=312 XBD=461 XBD=527 XBD=641 XBD=776 XBD=892 XBD=1083 XBD=1244 XBD=1313 XHG=140 XHG=254 XHG=336 XHG=484 XHG=551 XHG=668 XHG=916YBD=464 XHG=1107 XHG=1269 YBD=467 YBD=466 YBD=465 YBD=471 YBD=464 YBD=475YHG=431>that YBD=464 YHG=434>aims YHG=431>for YHG=431>which YHG=434>to YHG=430>live, YHG=431>work YHG=431>satisfies YHG=431>higher YHG=441>as XBD=219 XHG=869 XBD=287 XBD=420 XBD=676 XBD=838 XBD=892 XBD=1145 XBD=1219 XBD=1312 XHG=141 XHG=246 XHG=314 XHG=447 XHG=705 XHG=919YBD=512 XHG=1174 XHG=1242 YBD=516 YBD=515 YBD=514 YBD=520 YBD=524 YBD=513YHG=491>a YHG=481>well YHG=493>as YHG=492>more YHG=479>immediate YHG=479>needs, YHG=480>tightening YHG=478>of YHG=479>the XBD=258 XHG=634 XBD=400 XBD=526 XBD=615 XBD=885 XBD=1084 XBD=1183 XBD=1313 XHG=141 XHG=277 XHG=419 XHG=544 XHG=901YBD=573 XHG=1103 XHG=1201 YBD=566 YBD=563 YBD=562 YBD=573 YBD=563YHG=530>community YBD=562 YHG=530>bonds YHG=530>which YHG=529>draw YHG=539>our YHG=525>together YHG=528>and YHG=529>unite XBD=170 XHG=814 XBD=283 XBD=373 XBD=475 XBD=542 XBD=788 XBD=978 XBD=1053 XBD=1310 XHG=141 XHG=192 XHG=305 XHG=395 XHG=499 XHG=562 XHG=1001YBD=622 XHG=1075 YBD=615 YBD=613 YBD=612 YBD=611 YBD=612YHG=578>provide YBD=623 YHG=581>it YHG=580>with YHG=579>the YHG=581>rest YHG=577>of YHG=577>humanity, YHG=589>an YHG=578>inspiration
WOOD
" XBD=1185 |>" XBD=257 XBD=378 XBD=528 XBD=601 XBD=748 XBD=851 XBD=1311 XHG=141 XHG=288 XHG=411 XHG=558 XHG=632 XHG=782 XHG=883 XHG=1211 YBD=663 YBD=662 YBD=661 YBD=660 YBD=661 YBD=662 YHG=629>which YHG=628>does YHG=627>much YHG=629>to YHG=626>offset YHG=627>the YHG=627>circumstances YHG=628>-that
" XBD=993 XBD=223 XHG=806 XBD=294 XBD=662 XBD=775 XHG=141 YBD=710 XHG=251 XHG=325 XHG=695 YBD=713 YHG=677>neurosis. YBD=711 YBD=721 YHG=678>lead YHG=681>to YHG=677>discouragement YHG=676>and MEASURING SULPHONAMIDE ACTIVITY
" XBD=1244 XBD=1313XHG=507 XBD=275 XBD=433 XBD=494 XBD=896 XBD=1051 XHG=190 XHG=292 XHG=450 XHG=913YBD=873 XHG=1069 XHG=1262 YBD=864 YBD=874 YBD=863 YBD=873 YBD=874YHG=829>chemotherapeutic YBD=863 YHG=830>THE YHG=829>dosage YHG=828>of YHG=831>agents YHG=828>depends YHG=840>on " XBD=1313 XBD=165 XHG=704 XBD=279 XBD=458 XBD=518 XBD=689 XBD=830 XBD=891 XBD=1030 XBD=1168 XBD=1227 XHG=847 XHG=144 XHG=179 XHG=294 XHG=474 XHG=529 XHG=902YBD=912 XHG=1045 XHG=1184 XHG=1243 YBD=914 YBD=924 YBD=919 YBD=923 YBD=912 YBD=912YHG=877>of YHG=892>a YHG=879>large YHG=878>number YHG=877>factors, YHG=889>many YHG=878>which YHG=878>relate YHG=881>to YHG=878>the " XBD=1312 XBD=239 XHG=777 XBD=416 XBD=549 XBD=745 XBD=923 XBD=1150 XHG=145 XHG=305 XHG=446 XHG=580 XHG=956YBD=969 XHG=1184 YBD=963 YBD=961 YBD=968 YBD=962YHG=928>action, YHG=929>host. YHG=928>Even YHG=928>their YHG=928>in-vitro YHG=927>however, YHG=929>varies
" " " " "
XBD=1313XHG=665 XBD=289 XBD=433 XBD=640 XBD=900 XBD=1006 XBD=1100 XBD=1216 XHG=144 XHG=310 XHG=456 XHG=926YBD=1017 XHG=1029 XHG=1124 XHG=1240 YBD=1022 YBD=1011 YBD=1010 YBD=1011YHG=977>conditions, YBD=1021 YBD=1022 YHG=977>greatlv YHG=977>under YHG=976>different YHG=977>and YHG=980>not YHG=977>long YHG=988>ago XBD=174 XHG=868 XBD=273 XBD=467 XBD=544 XBD=843 XBD=911 XBD=1208 XBD=1315 XHG=145 XHG=198 XHG=299 XHG=492 XHG=568 XHG=937YBD=1060 XHG=1234 YBD=1061 YBD=1060 YBD=1071YHG=1029>to YHG=1029>it YHG=1038>was YHG=1026>counted YHG=1036>an YHG=1026>achievement YHG=1026>demonstrate YHG=1037>any XBD=299 XHG=842 XBD=479 XBD=534 XBD=672 XBD=826 XBD=886 XBD=1049 XBD=1313 XHG=146 XHG=310 XHG=492 XHG=549 XHG=686 XHG=898YBD=1110 XHG=1063 YBD=1111 YBD=1121 YBD=1120 YBD=1121 YBD=1121YHG=1074>of YHG=1077>in-vitro YHG=1076>activity YHG=1076>in YHG=1087>many YHG=1078>agents YHG=1075>proved YHG=1075>therapeutic XBD=264 XHG=821 XBD=425 XBD=789 XBD=890 XBD=1067 XBD=1313 XHG=146 XHG=316 XHG=456 XHG=920YBD=1159 XHG=1098 YBD=1160 YBD=1170 YBD=1159 YBD=1170YHG=1126>the YHG=1125>value. YHG=1125>With YHG=1125>sulphonamides, YHG=1124>factors YHG=1126>governing XBD=299 XHG=628 XBD=487 XBD=608 XBD=838 XBD=1006 XBD=1311 XHG=146 XHG=319 XHG=506 XHG=857YBD=1208 XHG=1025 YBD=1209 YBD=1219 YBD=1219 YBD=1219YHG=1174>now YHG=1175>in-vitro YHG=1175>activity YHG=1175>have YHG=1174>largely YHG=1174>disentangled. been
,
i
i
" XBD=1826 XBD=1994 XBD=2061 XHG=1536 XHG=1847 XHG=2017 XHG=2085 YBD=1254 YBD=1253 YHG=1233>ANTIBACTERIAL YHG=1233>INDICES YHG=1233>OF YHG=1233>SULPHONAMIDES " XBD=2389 XBD=222 XHG=810 XBD=373 XBD=438 XBD=638 XBD=789 XBD=913 XBD=1034 XBD=1250 XBD=1313 XHG=146 XHG=242 XHG=394 XHG=454 XHG=659 XHG=934YBD=1258 XHG=1054 XHG=1270 YBD=1257 YBD=1258 YBD=1258 YBD=1257 YHG=1224>The YHG=1223>effects YHG=1223>of YHG=1224>different YHG=1223>media YHG=1224>have YHG=1211>been YHG=1223>allocated YHG=1226>to
-
" XBD=2567 XBD=1597 XBD=1710 XBD=1835 XBD=1894 XBD=1978 XBD=2072 XBD=2234 XBD=2423 XHG=1420 XHG=1620 XHG=1733 XHG=1858 XHG=1918 XHG=2002 XHG=2095 XHG=2281 XHG=2446 YBD=1317 YBD=1316 YBD=1307 YBD=1309 YBD=1308 YHG=1280>Compiled YHG=1280>from YHG=1281>Wyss YHG=1282>et YHG=1280>a1.4 YHG=1280>and YHG=1279>Wood.3 YHG=1278>Wood’s YHG=1279>values XBD=297 XHG=895 XBD=592 XBD=865 XBD=939 XBD=1096 XBD=1312 XHG=147 XHG=329 XHG=621 XHG=968YBD=1307 XHG=1116 YBD=1318 YBD=1315 YBD=1307 YHG=1272>definite YHG=1274>antagonistic YHG=1272>substances, YHG=1272>of YHG=1273>which YHG=1274>p-amino|>" " XBD=1432 XBD=1484 XBD=1733 XBD=1852 XBD=1991 XBD=2059 XBD=2440 XBD=2513 XBD=2235 XHG=1375 XHG=1448 XHG=1498 XHG=1780 XHG=1867 XHG=2006 XHG=2251 XHG=2456 XHG=2528 XHG=2075 YBD=1356 YBD=1357 YBD=1348 YBD=1347 YBD=1348 YHG=1320>parentheses. YHG=1320>The YHG=1320>figures YHG=1320>for YHG=1320>organisms YHG=1329>are YHG=1320>in YHG=1320>different "" XBD=2566 XBD=326 XBD=379 XBD=467 XBD=681 XBD=788 XBD=967 XBD=1054 XBD=1164 XBD=1313 XHG=147 XHG=347 XHG=399 XHG=488 XHG=702 XHG=843 XHG=989 XHG=1074 XHG=1183 YBD=1368 YBD=1357 YBD=1357 YBD=1357 YBD=1367 YHG=1323>benzoate YHG=1323>is YHG=1323>the YHG=1322>principal YHG=1334>one. YHG=1323>These YHG=1334>are YHG=1334>now YHG=1334>recogXBD=1434 XBD=1548 XBD=1797 XBD=1883 XBD=1963 XBD=2129 XBD=2184 XBD=2350 XBD=2565 XHG=1374 XHG=1453 XHG=1568 XHG=1818 XHG=1900 XHG=1982 XHG=2147 XHG=2204 XHG=2369 YBD=1387 YBD=1397 YBD=1396 YBD=1388 YHG=1360>the YHG=1360>main YHG=1360>comparable, YHG=1360>but YHG=1363>not YHG=1360>entirely YHG=1369>so YHG=1360>because YHG=1360>conditions "" XBD=1315 XBD=250 XBD=346 XBD=416 XBD=682 XBD=858 XBD=975 XBD=1047 XBD=1218 XHG=148 XHG=277 XHG=374 XHG=445 XHG=710 XHG=1003 XHG=1075 XHG=1245 YBD=1407 YBD=1406 YBD=1407 YBD=1417 YBD=1406 YHG=1372>nised YHG=1375>not YHG=1384>as YHG=1376>extraneous YHG=1372>factors YHG=1375>sent YHG=1376>to YHG=1372>plague YHG=1372>the XBD=1415XHG=888 XBD=1563 XBD=1665 XBD=1744 XBD=1899 XHG=1375 XHG=1428 XHG=1577 XHG=1680 XHG=1759 YBD=1435 YBD=1427 YBD=1428 YHG=1399>of YHG=1400>growth YHG=1408>were YHG=1402>not YHG=1399>inform.
" XBD=1320 XBD=469 XHG=653 XBD=567 XBD=634 XBD=936 XBD=1002 XBD=1094 XBD=1252 XHG=149 XHG=494 XHG=591 XHG=958YBD=1460 XHG=1025 XHG=1118 XHG=1276 YBD=1467 YBD=1456 YBD=1456 YBD=1456YHG=1421>fundamental YHG=1421>chemotherapist YHG=1422>but YHG=1434>as YHG=1425>to YHG=1422>the YHG=1423>action YHG=1421>of XBD=211 XHG=913 XBD=375 XBD=511 XBD=873 XBD=979 XBD=1315 XHG=149 XHG=248 XHG=429 XHG=552 XHG=1019YBD=1505 YBD=1515 YBD=1504 YBD=1516 YBD=1505YHG=1483>are YHG=1471>the YHG=1471>drugs. YHG=1471>The YHG=1471>sulphonamides YHG=1471>bacteriostatic "" XBD=2560 XBD=1675 XBD=1827 XBD=1903 XBD=2109 XBD=2186 XHG=1378 XHG=1710 XHG=1861 XHG=1938 XHG=2142 XHG=2222 YBD=1529 YBD=1519 YBD=1530 YHG=1483>sulphadiazine YHG=1484>equal YHG=1486>in YHG=1485>activity YHG=1487>to YHG=1484>sulphapyridine, XBD=303 XHG=807 XBD=425 XBD=532 XBD=781 XBD=954 XBD=1022 XBD=1245 XBD=1315 XHG=150 XHG=328 XHG=451 XHG=543 XHG=979YBD=1555 XHG=1048 XHG=1272 YBD=1554 YBD=1558 YBD=1565 YBD=1554 YBD=1554YHG=1520>similar YHG=1520>because YHG=1520>they YHG=1532>are YHG=1520>sufficiently YHG=1521>in YHG=1523>structure YHG=1523>to "" XBD=2561 XBD=1990 XBD=2099 XBD=2237 XBD=2296 XBD=2475 XHG=1847 XHG=2002 XHG=2113 XHG=2254 XHG=2312 XHG=2491 YBD=1579 YBD=1568 YBD=1580 YBD=1569 YHG=1537>2 YHG=1535>with YHG=1534>Wyss YHG=1535>in YHG=1536>putting YHG=1535>the agree XBD=1492 XBD=1626 XBD=1724 XHG=1379 XHG=1510 XHG=1644 YHG=1533>while YHG=1534>RosE YHG=1534>and XBD=504 XHG=856 XBD=599 XBD=734 XBD=810 XBD=960 XBD=1080 XBD=1317 XHG=147 XHG=556 XHG=644 XHG=777 XHG=1011YBD=1604 XHG=1133 YBD=1615 YBD=1604YHG=1569>from YHG=1570>p-aminobenzoate YHG=1573>to YHG=1574>oust YHG=1571>it YHG=1570>the YHG=1569>essential "" XBD=2563 XBD=1550 XBD=1612 XBD=1932 XBD=2069 XBD=2130 XBD=2240 XBD=2302 XHG=1379 XHG=1569 XHG=1636 XHG=1951 XHG=2086 XHG=2148 XHG=2259 XHG=2317 YBD=1629 YBD=1618 YBD=1619 YBD=1630 YHG=1584>activity YHG=1583>of YHG=1583>sulphadiazine YHG=1584>equal YHG=1587>to YHG=1584>that YHG=1584>of YHG=1584>sulphathia"" XBD=1317 XBD=325 XBD=547 XBD=714 XBD=823 XBD=907 XBD=1055 XHG=152 XHG=365 XHG=587 XHG=753 XHG=962 XHG=1095 YBD=1664 YBD=1653 YBD=1653 YBD=1654 YHG=1619>bacterial YHG=1631>enzymes YHG=1620>which YHG=1632>use YHG=1620>This YHG=1619>functional XBD=1474XHG=862 XBD=1584 XBD=1680 XBD=1999 XBD=2179 XBD=2327 XBD=2474 XBD=2564 XHG=1379YBD=1654 XHG=1530 XHG=1610 XHG=1712 XHG=2026 XHG=2199 XHG=2355 XHG=2494 YBD=1679YHG=1621>it. YBD=1668 YHG=1633>zole. YHG=1633>Of YHG=1633>the YHG=1630>conditions YHG=1633>growth YHG=1634>which YHG=1634>affect YHG=1634>the ’of "" XBD=1317 XBD=393 XBD=461 XBD=859 XBD=956 XBD=1071 XBD=1195 XHG=152 XHG=418 XHG=484 XHG=884 XHG=981 XHG=1096 XHG=1219 YBD=1713 YBD=1703 YBD=1703 YBD=1702 YHG=1668>relationship YHG=1672>to YHG=1669>p-aminobenzoate YHG=1670>has YHG=1680>now YHG=1669>been XBD=1811 XHG=2519 XBD=1920 XBD=2080 XBD=2108 XBD=2238 XBD=2402 XBD=2493 XBD=2563 XHG=1379 YBD=1718 XHG=1839 XHG=1947 XHG=2094 XHG=2135 XHG=2265 XHG=2423 YBD=1724 YHG=1669>used YBD=1704 YBD=1717 YBD=1729 YHG=1680>indices,JScHMELKES YHG=1683>and YHG=1684>others YHG=1686>5 YHG=1683>have YHG=1683>shown YHG=1684>pH YHG=1687>to "" XBD=1317 XBD=188 XBD=304 XBD=550 XBD=722 XBD=800 XBD=904 XBD=1137 XBD=1217 XHG=149 XHG=221 XHG=337 XHG=586 XHG=757 XHG=940 XHG=1173 XHG=1247 YBD=1763 YBD=1752 YBD=1752 YHG=1719>give YHG=1718>numerical YHG=1718>values YHG=1721>to YHG=1718>activities YHG=1717>of YHG=1718>the XBD=1428XHG=835 XBD=1487 XBD=1776 XBD=2045 XBD=2139 XBD=2253 XBD=2565 XHG=1379YBD=1752 XHG=1443 XHG=1498 XHG=1786 XHG=2059 XHG=2150 XHG=2265 YBD=1778YHG=1718>the YBD=1767 YHG=1732>be YHG=1733>of YHG=1733>fundamental YHG=1734>importance, YHG=1733>and YHG=1733>have YHG=1733>demonstrated "" XBD=1316 XBD=321 XBD=688 XBD=826 XBD=963 XBD=1089 XBD=1254 XHG=151 XHG=357 XHG=744 XHG=861 XHG=1001 XHG=1127 XHG=1291 YBD=1813 YBD=1802 YBD=1814 YBD=1802 YBD=1803 YHG=1767>different YHG=1767>sulphonamides. YHG=1768>The YHG=1769>ratio YHG=1768>S/P, YHG=1768>where XBD=1472 XHG=2467 XBD=1556 XBD=1745 XBD=1803 XBD=1991 XBD=2051 XBD=2115 XBD=2451 XBD=2564 XHG=1379 YBD=1817 XHG=1486 XHG=1571 XHG=1760 XHG=1817 XHG=2006 XHG=2062 XHG=2130 YBD=1828 YHG=1768>S YHG=1782>that YHG=1783>the YHG=1783>increase YHG=1784>in YHG=1786>potency YHG=1782>of YHG=1782>all YHG=1782>sulphonamides YHG=1783>with "" XBD=1317 XBD=355 XBD=468 XBD=814 XBD=904 XBD=969 XHG=149 XHG=400 XHG=515 XHG=860 XHG=946 XHG=1016 YBD=1863 YBD=1852 YBD=1851 YBD=1863 YHG=1821>represents YHG=1818>the YHG=1819>concentration YHG=1817>of YHG=1830>a XBD=1554 XHG=2471 XBD=1617 XBD=1707 XBD=1761 XBD=1825 XBD=1989 XBD=2107 XBD=2242 XBD=2450 XBD=2564 XHG=1380 YBD=1867 XHG=1575 XHG=1638 XHG=1728 XHG=1782 XHG=1846 XHG=2009 XHG=2129 XHG=2264 YBD=1878 YHG=1817>sulphonamide YHG=1832>increase YHG=1833>pH YHG=1834>is YHG=1833>in YHG=1832>accord YHG=1833>with YHG=1832>other YHG=1832>evidence YHG=1833>that "" XBD=1318 XBD=343 XBD=416 XBD=781 XBD=864 XBD=1063 XBD=1123 XHG=152 XHG=357 XHG=432 XHG=879 XHG=1078 XHG=1134 YBD=1912 YBD=1902 YBD=1913 YBD=1901 YHG=1879>necessary YHG=1866>for YHG=1867>bacteriostasis YHG=1879>presence YHG=1867>of YHG=1867>different in XBD=1449XHG=795 XBD=1608 XBD=1880 XBD=1995 XBD=2064 XBD=2107 XBD=2433 XBD=2490 XBD=2566 XHG=1379YBD=1901 XHG=1474 XHG=1630 XHG=1903 XHG=2019 XHG=2083 XHG=2132 XHG=2456 XHG=2513 YBD=1917YHG=1868>the YBD=1928 YBD=1916 YHG=1882>the YHG=1882>actual YHG=1882>functioning YHG=1885>part YHG=1882>of YHG=1895>a YHG=1881>sulphonamide YHG=1883>is YHG=1894>an "" XBD=1317 XBD=454 XBD=509 XBD=576 XBD=980 XBD=1037 XBD=1204 XHG=153 XHG=477 XHG=532 XHG=592 XHG=1004 XHG=1059 XHG=1227 YBD=1952 YBD=1951 YBD=1962 YBD=1950 YBD=1951 YHG=1918>concentrations YHG=1917>P YHG=1917>of YHG=1917>p-aminobenzoate, YHG=1918>is YHG=1917>almost YHG=1928>conXBD=1513 XHG=2432 XBD=1617 XBD=1825 XBD=1885 XBD=2080 XBD=2418 XBD=2564 XHG=1381 YBD=1966 XHG=1567 XHG=1633 XHG=1841 XHG=1897 XHG=2096 YBD=1967 YHG=1932>whose YBD=1978 YHG=1933>anion. YHG=1932>In YHG=1932>solutions YHG=1932>of YHG=1932>different YHG=1932>sulphonamides "" XBD=1317 XBD=251 XBD=325 XBD=365 XBD=498 XBD=817 XBD=915 XBD=955 XBD=1089 XHG=152 XHG=267 XHG=343 XHG=382 XHG=515 XHG=835 XHG=972 XHG=1107 YBD=2012 YBD=2012 YBD=2012 YHG=1970>stant YHG=1966>for YHG=1968>given YHG=1966>sulphonamide YHG=1967>and YHG=1967>given YHG=1968>organism, XBD=1564XHG=932 XBD=1620 XBD=1831 XBD=1897 XBD=2009 XBD=2150 XBD=2356 XBD=2449 XBD=2563 XHG=1382YBD=2001 XHG=1587 XHG=1644 XHG=1853 XHG=1921 XHG=2033 XHG=2173 XHG=2380 XHG=2475 YBD=2026YHG=1979>a YBD=2027 YBD=2016 YBD=2015 YHG=1982>strength YHG=1983>is YHG=1981>adjusted YHG=1985>to YHG=1983>give YHG=1982>equal YHG=1982>activity, YHG=1982>the YHG=1992>con"" XBD=1323 XBD=225 XBD=271 XBD=309 XBD=506 XBD=570 XBD=653 XBD=813 XBD=1108 XBD=1260 XHG=153 XHG=240 XHG=290 XHG=329 XHG=526 XHG=584 XHG=672 XHG=830 XHG=1127 XHG=1280 YBD=2050 YBD=2051 YBD=2062 YBD=2051 YBD=2050 YBD=2051 YHG=2014>and YHG=2017>is YHG=2028>a YHG=2028>measure YHG=2016>of YHG=2016>the YHG=2016>purely YHG=2016>antibacterial YHG=2017>action XBD=1626 XHG=2415 XBD=1690 XBD=1843 XBD=1928 XBD=1991 XBD=2075 XBD=2202 XBD=2337 XBD=2400 XBD=2564 XHG=1383 YBD=2076 XHG=1646 XHG=1704 XHG=1862 XHG=1947 XHG=2005 XHG=2094 XHG=2221 XHG=2356 YBD=2066 YHG=2016>of YHG=2032>centrations YHG=2033>anions YHG=2043>are YHG=2032>the YHG=2043>same YHG=2031>order YHG=2031>of YHG=2032>magni" XBD=1320 XBD=215 XHG=657 XBD=334 XBD=470 XBD=641 XBD=738 XBD=1000 XBD=1060 XBD=1147 XHG=154 XHG=230 XHG=388 XHG=486 XHG=752YBD=2100 XHG=1016 XHG=1078 XHG=1164 YBD=2101 YBD=2112 YBD=2101 YBD=2107YHG=2066>this YBD=2100 YHG=2067>the YHG=2066>drug. YHG=2066>The YHG=2065>smaller YHG=2066>ratio-that YHG=2067>is, YHG=2066>the YHG=2066>smaller " XBD=1321 XBD=216 XHG=818 XBD=424 XBD=494 XBD=615 XBD=793 XBD=880 XHG=155 XHG=242 XHG=450 XHG=516 XHG=641 XHG=905YBD=2150 YBD=2161 YBD=2150YHG=2115>for YHG=2117>the YHG=2117>quantity YHG=2115>of YHG=2116>drug YHG=2115>needed YHG=2116>bacteriostasis-the " XBD=1321 XBD=252 XHG=893 XBD=425 XBD=538 XBD=628 XBD=750 XBD=873 XBD=955 XBD=1045 XBD=1216 XBD=1270 XHG=158 XHG=273 XHG=445 XHG=559 XHG=650 XHG=770 XHG=975YBD=2200 XHG=1065 XHG=1236 XHG=1289 YBD=2210 YBD=2199 YBD=2210YHG=2165>for YBD=2199 YHG=2177>more YHG=2165>affinity YHG=2165>does YHG=2166>the YHG=2165>drug YHG=2165>have YHG=2165>the YHG=2168>system YHG=2166>it YHG=2166>is " XBD=1323 XBD=374 XHG=835 XBD=532 XBD=680 XBD=810 XBD=925 XBD=1051 XHG=157 XHG=428 XHG=557 XHG=706 XHG=951YBD=2250 XHG=1076 YBD=2260 YBD=2249 YBD=2249 YBD=2249YHG=2227>now YHG=2216>disturbing. YHG=2215>Such YHG=2216>ratios YHG=2215>have YHG=2215>been YHG=2215>determined " XBD=1324 XBD=209 XHG=773 XBD=386 XBD=633 XBD=744 XBD=919 XBD=1062 XBD=1193 XHG=157 XHG=235 XHG=417 XHG=663 XHG=964YBD=2310 XHG=1090 XHG=1224 YBD=2300 YBD=2299 YBD=2309 YBD=2299YHG=2265>drugs YHG=2264>for YHG=2266>various YHG=2265>organisms YHG=2264>and YHG=2264>they YHG=2265>have; YHG=2265>been "" XBD=1322 XBD=311 XBD=375 XBD=441 XBD=942 XBD=1008 XBD=1074 XHG=156 XHG=332 XHG=399 XHG=465 XHG=965 XHG=1032 XHG=1097 YBD=2349 YBD=2348 YBD=2356 YBD=2348 YBD=2348 YBD=2359 YHG=2315>referred YHG=2318>to YHG=2326>as YHG=2314>antibacterial’indices,l YHG=2325>or YHG=2325>as XBD=1498 XHG=2498 XBD=1725 XBD=1836 XBD=2161 XBD=2353 XBD=2445 XBD=2567 XHG=1385 YBD=2371 XHG=1546 XHG=1766 XHG=1883 XHG=2205 XHG=2401 YBD=2373 YHG=2315>measuring YBD=2374 YBD=2372 YHG=2350>ences YHG=2339>between YHG=2339>the YHG=2338>antibacterial YHG=2338>indices YHG=2337>of YHG=2337>the "" XBD=1322 XBD=436 XBD=671 XBD=785 XBD=921 XBD=1186 XHG=158 XHG=470 XHG=705 XHG=817 XHG=953 XHG=1219 YBD=2399 YBD=2409 YBD=2398 YBD=2409 YBD=2398 YHG=2365>bacteriostatic YHG=2366>potency,2 YHG=2364>and YHG=2364>their YHG=2364>reciprocals YHG=2364>have XBD=1706 XBD=1796 XBD=1844 XBD=1985 XBD=2207 XBD=2387 XHG=1385 XHG=1735 XHG=1820 XHG=1867 XHG=2008 XHG=2237 XHG=2411 YBD=2434 YBD=2423 YBD=2422 YBD=2433 YBD=2432 YHG=2388>sulphonamides YHG=2388>for YHG=2400>a YHG=2390>given YHG=2389>organism YHG=2387>largely YHG=2387>depend "" XBD=2567 XBD=245 XBD=412 XBD=757 XBD=1043 XBD=1208 XBD=1321 XHG=156 XHG=293 XHG=461 XHG=808 XHG=1095 XHG=1255 YBD=2449 YBD=2448 YBD=2448 YBD=2458 YBD=2447 YHG=2414>been YHG=2414>called YHG=2414>bacteriostatic YHG=2416>constants.3 YHG=2413>They XBD=1437 XHG=2140 XBD=1528 XBD=1719 XBD=1788 XBD=1927 XBD=1991 XBD=2117 XBD=2345 XHG=1385 YBD=2472 XHG=1459 XHG=1552 XHG=1743 XHG=1807 XHG=1949 XHG=2012 YBD=2471 YHG=2425>are YHG=2449>on YHG=2439>the YHG=2441>amount YHG=2438>of YHG=2439>anion YHG=2439>in YHG=2438>their YHG=2437>solutions. "" XBD=1316 XBD=325 XBD=487 XBD=546 XBD=757 XBD=1164 XHG=156 XHG=337 XHG=504 XHG=563 XHG=776 XHG=1183 YBD=2508 YBD=2498 YBD=2497 YBD=2508 YBD=2504 YHG=2463>formally YHG=2463>related YHG=2467>to YHG=2462>Ehrlich’s YHG=2463>chemotherapeutic YHG=2462>index, XBD=1486 XBD=1597 XBD=1765 XBD=1861 XBD=1935 XBD=2281 XBD=2434 XHG=1436 XHG=1513 XHG=1611 XHG=1792 XHG=1890 XHG=1959 XHG=2309 XHG=2460 YBD=2522 YBD=2534 YBD=2521 YBD=2532 YBD=2520 YHG=2488>In YHG=2488>the YHG=2487>clinical YHG=2499>use YHG=2486>of YHG=2487>sulphonamides YHG=2498>many YHG=2497>more "" XBD=2569 XBD=296 XBD=393 XBD=646 XBD=706 XBD=791 XBD=1097 XBD=1213 XBD=1322 XHG=156 XHG=326 XHG=427 XHG=673 XHG=735 XHG=820 XHG=1133 XHG=1248 YBD=2558 YBD=2547 YBD=2546 YBD=2557 YBD=2558 YBD=2547 YBD=2546 YHG=2513>though YHG=2513>the YHG=2514>connexion YHG=2513>is YHG=2512>by YHG=2513>computation YHG=2513>and YHG=2517>not XBD=1814 XBD=1909 XBD=2177 XBD=2273 XBD=2570 XHG=1384 XHG=1866 XHG=1961 XHG=2230 XHG=2325 YBD=2571 YBD=2570 YBD=2581 YHG=2525>factors-differences YHG=2536>solubility, YHG=2537>in YHG=2536>absorption, experiment. "" XBD=287 XBD=219 XHG=157 XHG=236 YBD=2608 YBD=2607 YHG=2568>yet YHG=2564>by XBD=1659 XBD=1773 XBD=2007 XBD=2096 XBD=2198 XBD=2323 XBD=2440 XBD=2573 XHG=1386 XHG=1692 XHG=1806 XHG=2042 XHG=2128 XHG=2231 XHG=2357 XHG=2472 YBD=2630 YBD=2621 YBD=2620 YHG=2587>detoxication YHG=2586>and YHG=2586>excretion YHG=2586>by YHG=2586>the YHG=2586>host YHG=2585>and YHG=2597>even "" XBD=1321 XBD=278 XBD=432 XBD=494 XBD=632 XBD=733 XBD=911 XBD=1100 XBD=1183 XHG=202 XHG=294 XHG=451 XHG=508 XHG=652 XHG=750 XHG=1059 XHG=1114 XHG=1200 YBD=2647 YBD=2646 YBD=2652 YBD=2646 YBD=2653 YHG=2613>The YHG=2612>results YHG=2612>of YHG=2613>WYSS YHG=2611>and YHG=2611>others,4 YHG=2613>in YHG=2611>the YHG=2611>table, given XBD=1427 XBD=1697 XBD=1797 XBD=2063 XBD=2133 XBD=2277 XBD=2381 XBD=2573 XHG=1384 XHG=1446 XHG=1717 XHG=1818 XHG=2084 XHG=2152 XHG=2296 XHG=2403 YBD=2671 YBD=2681 YBD=2669 YBD=2670 YHG=2637>in YHG=2636>availability YHG=2635>and YHG=2638>cost-must YHG=2635>be YHG=2635>taken YHG=2636>into YHG=2639>account "" XBD=1322 XBD=315 XBD=423 XBD=484 XBD=602 XBD=951 XBD=1054 XBD=1173 XHG=158 XHG=333 XHG=440 XHG=503 XHG=621 XHG=971 XHG=1072 XHG=1192 YBD=2696 YBD=2697 YBD=2707 YBD=2706 YBD=2695 YBD=2696 YHG=2663>indicate YHG=2663>that YHG=2665>to YHG=2662>both YHG=2661>sulphanilamide YHG=2662>(the YHG=2660>least YHG=2663>active XBD=1427 XBD=1649 XBD=1754 XBD=1890 XBD=2014 XBD=2182 XBD=2261 XBD=2321 XHG=1385 XHG=1463 XHG=1684 XHG=1790 XHG=1926 XHG=2051 XHG=2216 XHG=2297 XHG=2356 YBD=2730 YBD=2720 YBD=2719 YBD=2731 YHG=2687>in YHG=2686>choosing YHG=2685>the YHG=2685>drug YHG=2684>best YHG=2685>suited YHG=2688>to YHG=2697>a YHG=2685>particular "" XBD=2572 XBD=258 XBD=382 XBD=738 XBD=868 XBD=1017 XBD=1206 XBD=1322 XHG=156 XHG=304 XHG=425 XHG=784 XHG=912 XHG=1062 XHG=1252 YBD=2746 YBD=2757 YBD=2756 YBD=2745 YBD=2756 YBD=2745 YHG=2712>drug) YHG=2712>and YHG=2711>sulphathiazole YHG=2711>(the YHG=2714>most YHG=2712>active) YHG=2711>the XBD=1569 XBD=1700 XBD=1923 XBD=2012 XBD=2185 XBD=2572 XHG=1386 XHG=1622 XHG=1730 XHG=1955 XHG=2045 XHG=2216 YBD=2776 YBD=2769 YBD=2770 YBD=2781 YHG=2747>purpose. YHG=2735>For YHG=2735>instance, YHG=2747>we YHG=2734>choose YHG=2735>sulphaguanidine "" XBD=1324 XBD=459 XBD=523 XBD=657 XBD=894 XBD=1012 XBD=1072 XHG=157 XHG=479 XHG=537 XHG=676 XHG=911 XHG=1030 XHG=1090 YBD=2796 YBD=2795 YBD=2806 YBD=2794 YBD=2794 YBD=2806 YHG=2761>susceptibilities YHG=2761>of YHG=2772>seven YHG=2761>organisms YHG=2772>were YHG=2761>in YHG=2760>practically XBD=1429 XBD=1596 XBD=1828 XBD=2072 XBD=2292 XBD=2376 XBD=2573 XHG=1385 XHG=1457 XHG=1622 XHG=1854 XHG=2099 XHG=2323 XHG=2408 YBD=2819 YBD=2829 YBD=2831 YBD=2820 YHG=2788>to YHG=2785>attack YHG=2784>intestinal YHG=2785>organisms YHG=2785>although YHG=2787>its YHG=2786>in-vitro "" XBD=1323 XBD=220 XBD=337 XBD=492 XBD=594 XBD=713 XBD=909 XBD=994 XBD=1160 XBD=1237 XHG=159 XHG=236 XHG=356 XHG=524 XHG=609 XHG=731 XHG=925 XHG=1011 XHG=1176 XHG=1253 YBD=2853 YBD=2845 YBD=2844 YBD=2844 YHG=2822>same YHG=2811>order YHG=2811>the YHG=2811>ratio YHG=2810>between YHG=2810>the YHG=2810>indices YHG=2810>for YHG=2811>the ; XBD=1558 XBD=1611 XBD=1721 XBD=1841 XBD=1931 XBD=2062 XBD=2205 XBD=2271 XBD=2361 XBD=2509 XBD=2577 XHG=1387 XHG=1579 XHG=1633 XHG=1778 XHG=1861 XHG=1948 XHG=2083 XHG=2228 XHG=2291 XHG=2377 XHG=2532 YBD=2879 YBD=2868 YBD=2876 YBD=2870 YBD=2869 YHG=2835>activity YHG=2835>is YHG=2834>low. YHG=2833>On YHG=2834>the YHG=2834>other YHG=2834>hand, YHG=2835>in YHG=2836>the YHG=2836>choice YHG=2834>of "" XBD=1321 XBD=230 XBD=367 XBD=471 XBD=613 XBD=708 XBD=841 XBD=963 XBD=1085 XHG=158 XHG=253 XHG=392 XHG=495 XHG=639 XHG=734 XHG=866 XHG=988 XHG=1112 YBD=2904 YBD=2894 YBD=2893 YBD=2893 YBD=2904 YHG=2862>two YHG=2860>drugs YHG=2853>was YHG=2860>much YHG=2860>the YHG=2871>same YHG=2859>with YHG=2859>each YHG=2860>organism. XBD=1701 XBD=1776 XBD=2110 XBD=2204 XBD=2352 XHG=1388 XHG=1714 XHG=1790 XHG=2124 XHG=2217 XHG=2363 YBD=2929 YBD=2917 YBD=2928 YBD=2918 YBD=2919 YBD=2920 YHG=2883>sulphathiazole YHG=2882>for YHG=2883>staphylococcal YHG=2884>and YHG=2884>mixed YHG=2884>infections "" XBD=2575 XBD=269 XBD=321 XBD=482 XBD=577 XBD=760 XBD=892 XBD=980 XBD=1050 XBD=1137 XBD=1324 XHG=157 XHG=281 XHG=337 XHG=497 XHG=594 XHG=777 XHG=909 XHG=998 XHG=1066 XHG=1155 YBD=2951 YBD=2944 YBD=2954 YBD=2943 YBD=2943 YBD=2943 YBD=2954 YHG=2908>Thus, YHG=2921>as YHG=2909>GREEN YHG=2909>and YHG=2909>PARKIN YHG=2910>point YHG=2911>out YHG=2920>on YHG=2920>our YHG=2910>opening XBD=1667 XBD=1819 XBD=1882 XBD=1981 XBD=2237 XBD=2573 XHG=1388 XHG=1696 XHG=1848 XHG=1912 XHG=2013 XHG=2270 YBD=2968 YBD=2967 YBD=2980 YBD=2969 YHG=2933>antibacterial YHG=2932>index YHG=2934>is YHG=2933>the YHG=2935>overriding YHG=2934>consideration. "" XBD=1323 XBD=260 XBD=310 XBD=358 XBD=399 XBD=561 XBD=621 XBD=751 XBD=860 XBD=896 XBD=1125 XHG=160 XHG=279 XHG=326 XHG=376 XHG=416 XHG=578 XHG=633 XHG=768 XHG=873 XHG=910 XHG=1138 YBD=3002 YBD=3003 YBD=2993 YBD=2992 YBD=3003 YBD=3003 YHG=2970>page, YHG=2960>it YHG=2959>is YHG=2958>fallacy YHG=2962>to YHG=2958>think YHG=2959>that YHG=2970>a YHG=2958>particular YHG=2958>sulphonXBD=1497 XBD=1711 XBD=1882 XBD=1944 XBD=2069 XBD=2237 XBD=2413 XBD=2486 XBD=2574 XHG=1389 XHG=1517 XHG=1731 XHG=1902 XHG=1963 XHG=2090 XHG=2256 XHG=2433 XHG=2504 YBD=3027 YBD=3016 YBD=3018 YHG=2983>Thus YHG=2982>although YHG=2982>studies YHG=2984>in YHG=2984>vitro YHG=2987>cannot YHG=2983>include YHG=2984>all YHG=2985>the "" XBD=1325 XBD=278 XBD=326 XBD=500 XBD=579 XBD=621 XBD=855 XBD=1102 XBD=1204 XHG=159 XHG=296 XHG=348 XHG=517 XHG=598 XHG=638 XHG=879 XHG=1134 XHG=1219 YBD=3040 YBD=3042 YBD=3052 YBD=3052 YBD=3041 YHG=3007>amide YHG=3008>is YHG=3008>specific YHG=3008>for YHG=3020>a YHG=3008>particular YHG=3008>organism YHG=3007>the YHG=3010>most : XBD=1536 XBD=1692 XBD=1831 XBD=1912 XBD=1995 XBD=2264 XBD=2344 XBD=2575 XHG=1388 XHG=1563 XHG=1728 XHG=1867 XHG=1947 XHG=2035 XHG=2302 XHG=2383 YBD=3068 YBD=3066 YBD=3078 YHG=3031>factors YHG=3032>which YHG=3032>have YHG=3034>to YHG=3032>be YHG=3032>considered YHG=3034>in YHG=3034>practical "" XBD=1326 XBD=278 XBD=389 XBD=558 XBD=647 XBD=860 XBD=909 XBD=1122 XBD=1205 XHG=159 XHG=294 XHG=403 XHG=574 XHG=663 XHG=876 XHG=924 XHG=1135 XHG=1219 YBD=3089 YBD=3100 YBD=3101 YBD=3102 YBD=3091 YBD=3101 YBD=3090 YBD=3091 YHG=3057>active YHG=3056>drug YHG=3058>against YHG=3068>one YHG=3058>organism YHG=3057>is YHG=3056>normally YHG=3057>the YHG=3059>most XBD=1715 XBD=1840 XBD=1992 XBD=2121 XBD=2342 XBD=2473 XHG=1389 XHG=1770 XHG=1895 XHG=2051 XHG=2182 XHG=2404 XHG=2536 YBD=3126 YBD=3116 YBD=3127 YBD=3117 YBD=3118 YHG=3081>chemotherapy, YHG=3084>yet YHG=3082>with YHG=3083>the YHG=3085>present YHG=3094>use YHG=3083>of "" XBD=2581 XBD=278 XBD=457 XBD=549 XBD=696 XBD=895 XBD=1038 XBD=1108 XBD=1326 XHG=159 XHG=306 XHG=487 XHG=632 XHG=724 XHG=924 XHG=1066 XHG=1136 YBD=3138 YBD=3150 YBD=3140 YBD=3151 YBD=3140 YBD=3151 YHG=3105>active YHG=3106>against YHG=3105>all. YHG=3105>All YHG=3106>workers YHG=3117>agree YHG=3107>in YHG=3105>principle XBD=1546 XBD=1720 XBD=1854 XBD=1955 XBD=2125 XBD=2206 XBD=2358 XBD=2577 XHG=1389 XHG=1589 XHG=1754 XHG=1889 XHG=1990 XHG=2159 XHG=2239 XHG=2392 YBD=3166 YBD=3177 YBD=3165 YBD=3176 YBD=3167 YHG=3130>defined YHG=3131>media YHG=3131>they YHG=3143>are YHG=3133>giving YHG=3143>us YHG=3131>fairly YHG=3136>accurate "|>" XBD=372 XBD=530 XBD=624 XBD=732 XBD=936 XBD=1171 XBD=1326 XBD=247 XHG=265 XHG=389 XHG=550 XHG=643 XHG=752 XHG=954 XHG=1189 XHG=161 YBD=3187 YBD=3199 YBD=3189 YBD=3189 YBD=3187 YBD=3189 YHG=3154>these YHG=3155>results YHG=3155>but YHG=3156>give YHG=3155>different YHG=3155>numerical YHG=3154>with YHG=3154>values "" XBD=2579 XBD=1650 XBD=1751 XBD=1916 XBD=2162 XBD=2346 XHG=1389 XHG=1707 XHG=1796 XHG=1971 XHG=2217 XHG=2418 YBD=3225 YBD=3227 YBD=3215 YBD=3216 YHG=3179>information YHG=3180>of YHG=3184>great YHG=3181>practical YHG=3180>value. YHG=3181>Animal XBD=216 XBD=296 XBD=586 XBD=764 XBD=931 XBD=1142 XBD=1327 XHG=161 XHG=231 XHG=313 XHG=603 XHG=785 XHG=950 XHG=1159 YBD=3235 YBD=3236 YBD=3238 YBD=3245 YBD=3239 YBD=3249 YBD=3238 YHG=3201>for YHG=3203>the YHG=3204>antibacterial YHG=3204>indices, YHG=3204>almost YHG=3204>certainly YHG=3204>because "" XBD=2578 XBD=1651 XBD=1727 XBD=1882 XBD=1976 XBD=2302 XHG=1391 XHG=1694 XHG=1773 XHG=1927 XHG=2020 XHG=2350 YBD=3275 YBD=3264 YBD=3266 YBD=3271 YBD=3265 YHG=3230>experiment, YHG=3231>it YHG=3231>must YHG=3230>be YHG=3229>remembered, YHG=3231>introduces XBD=249 XBD=380 XBD=575 XBD=813 XBD=872 XBD=1035 XBD=1130 XBD=1328 XHG=159 XHG=262 XHG=394 XHG=591 XHG=827 XHG=878 XHG=1049 XHG=1143 YBD=3296 YBD=3297 YBD=3287 YBD=3288 YBD=3299 YBD=3288 YHG=3251>they YHG=3252>adopt YHG=3253>different YHG=3253>conditions YHG=3253>of YHG=3254>growth YHG=3254>and " XBD=2580 XBD=1478 XHG=2427 XBD=1591 XBD=1822 XBD=1998 XBD=2071 XBD=2171 XBD=2326 XBD=2400 XHG=1391 YBD=3314 XHG=1509 XHG=1619 XHG=1851 XHG=2028 XHG=2102 XHG=2203 XHG=2356 YBD=3315 YHG=3253>different YBD=3313 YBD=3322 YHG=3290>new YHG=3280>and YHG=3280>unknown YHG=3279>factors YHG=3283>to YHG=3280>the YHG=3279>study YHG=3280>of YHG=3281>human
" XBD=2569 |>" XBD=1510 XBD=1603 XBD=1660 XBD=1924 XBD=2010 XBD=2216 XBD=2409XHG=2440 XHG=1384 XHG=1562 XHG=1627 XHG=1685 XHG=1941 XHG=2035 XHG=2231YBD=2169 YBD=2182 YBD=2170 YBD=2181 YBD=2205YHG=2134>which YHG=2135>tude.6 YHG=2136>It YHG=2136>is YHG=2136>apparently YHG=2136>the YHG=2148>group YHG=2099>S
Fox
0 B0-
0
B0-
C5
1. McIlwain, H. Brit. J. exp. Path. 1942, 23, 95. " XBD=1614 XHG=1390 YBD=3363 YHG=3328>infections.
2. Rose, H. M. and Fox, C. L. jun. Science, 1942, 95, 412. 3. Wood, W. B. jun. J. exp. Med. 1942, 75, 369. 4. Wyss, O., Grunbaugh, K. K. and Schmelkes, F. C. Proc. Soc. exp. Biol., N.Y. 1942, 49, 618.
Schmelkes, F. C., Wyss, O., Marks, H. C., Ludwig, B. J. and Strandskov, F. B. Proc. Soc. exp. Biol., N.Y. 1942, 50, 145. 6. Fox, C. L. jun. and Rose, H. M. Ibid, 1942, 50, 142.
5.