638
R. A. RAVICH AND A. RAVICH
the possible applications of the concept of lipoacid-lipobase disproportion in pathological lesions in controlled ser...
the possible applications of the concept of lipoacid-lipobase disproportion in pathological lesions in controlled series of operative cases. The results indicate not only that this approach appears to be more efficient than other known methods of pain control, but that profound physiological changes are brought about within the area of operative trauma as reflected by the reduction in the severity of hemorrhage and improved healing. This concept and these studies merely open the way to further investigations along this line. Much more detailed information concerning the nature of the local physico-chemical changes within pathological foci and the means of controlling such changes are necessary. SUMMARY
A new concept of the local physico-chemical changes occurring within pathological foci as introduced by Revici, has been briefly described. According to this view, pain is the result of local pH changes brought about by the accumulation of acid or alkaline substances within disturbed tissues. Changes in the lipid balance are associated with and may account for these alterations. The possibility of correcting or neutralizing such lipid changes has been explored clinically in several series of urological cases. The favorable effects upon pain as well as upon bleeding, wound healing and other important postoperative problems and complications indicate the need for further study along these lines.
54 Greene Ave., Brooklyn, N. Y.
MEETING, NEW YORK SECTION, November I6, I949
Yale Club, New York City 8:30 P.M.
MIXED TUMORS OF THE KIDNEY IN CHILDHOOD DR. ROBERT
E.
GROSS,
Ladd Professor of Children's Surgery, Howard Medical School, · and Surgeon-in-Chief, the Children's Hospital, Boston