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POU Family Transcription Factor and not by Brn-3a or Brn-3c. J Bio/Chem 1995, 270:15143-15147 Mollard P, Seward EP, NowyckyMC: Activation of Nicotinic Receptors Triggers Exocytosis from Bovine Chromaffin Cells in the Absence of Membrane Depolarization. Proc Nat/Acad Sci USA 1995, 92:3065-3069. Monnet FP, Mahe V, Rebel P, Baulieu EE: Neurostaroids, Via Sigma Receptors, Modulate The [H-3]norepinephrine Release Evoked by N-methyI-D-aspartata in the Rat Hippocampus. Proc Nat/Acad Sci USA 1995, 92:3774-3778. Muller BM, Kistner U, Veh RW, Cases-LanghoffC, Becker • B, Gundelfinger ED, Garner CC: SAP97,a Novel Member of the Superfamily of Brain-related Guanylate Kinases. J Neurosci 1995, 15:2354-2366. [451 Niethammer M, Kim E, Sheng M: Interaction Between • the C-terminus of NMDA Receptor Subunits and Multiple Members of the PSD-95 Family of Membrene-associated Guanylate Kinases. J Neurosci 1996, 16:2157-2163. [35]. Nowak MW, KeameyPC, Sampson JR, Saks ME, Labarca CG, Silverman SK, Zhong WG, Thorson J, Abelson JN, Davidson N, Schultz PC, Dougherty DA, Lester HA: Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells. Science 1995, 268:439-442. Ohno K, Hutchinson DO, Milone M, BrengmanJM, Bouzat C, Sine SM, Engel AG: Congenital Myasthenic Syndrome Caused by Prolonged Acetylcholine Receptor Channel Openings Due to a mutation in the M2 Domain of the Epsilon Subunit. Pros Nat/ Acad Sci USA 1995, 92:758-762. Olivares L, Aragon C, Gimenez C, Zafra F: The Role of N-glycosylation in the Targeting and Activity of the GLYT1 Glycine Transporter. J Bio/Chem 1995, 270:9437-9442. Peter D, Vu T, Edwards RH: Chimeric Vesicular Monoamine Transporters Identify Structural Domains that Influence Substrate Affinity and Sensitivity to Tetrebenazine.J Bio/Chem 1996, 271:2979-2986. Picciotto MR, Zoll M, Lena C, Bessis A, Lallemand Y, Lenovere N, Vincent P, Pich EM, Brulet P, Changeux JP: Abnormal Avoidance Learning in Mice Lacking Functional High-affinity Nicotine Receptor in the Brain. Nature 1995, 374:65-67 Pollard S, Thompson CL, Stephenson FA: Quantitative Characterization of Alpha 6 and Alpha 1 Alpha 6 Subunit-containing Native Gamma-aminobutyric Acid(A) Receptors of Adult Rat Cerebellum Demonstrates Two Alpha Subunits Per Receptor Oligomer. J Biol Chem 1995, 270:21285-21290. Postma FR, Jalink K, HengeveldT, Bet AGM, Alblas J, Dejonge HR, MoolenaarWH: Serum-induced Membrane Depolarization in Quiescent Fibroblasts: Activation of a Chloride Conductance Through the G Protain-coupled LPA Receptor. EMBO J 1996, 15:63-72. Rathouz MM, VijayaraghavanS, Berg DK: Acetylcholine Differentially Affects Intrecellular Calcium Via Nicotinic and Muscarinic Receptors on the Same Population of Neurons, J Bio/Chem 1995, 270:14366-14375. Ray A, KyselovicJ, Leddy JJ, Wigle JT, Jasmin BJ, Tuana BS: Regulation of Dihydropyridine and Ryanodine Receptor Gene Expression in Skeletal Muscle - Role of Nerve, Protein Kinase C, and cAMP Pathways. J Biol Chem 1995, 270:25837-25844. Rosen LB, Greenberg ME: Stimulation of Growth Factor Receptor Signal Transduction by Activation of Voltage-sensitive Calcium Channels. Proc Nat/Acad Scl U S A 1996, 93:1113-1116. Shen BQ, Widdicombe JH, Mrsny RJ: Effects of Lovastatin on Trafficking of Cystic Fibrosis Transmembrane Conductance Regulator in Human Tracheal Epithelium. J Biol Chem 1995, 270:25102-25106. Shen BQ, Widdicombe JH, Mrsny RJ: Effects of Lovastatin on Trafficking, of Cystic Fibrosis Trensmembrene Conductance Regulator in Human Tracheal Epithelium (vol 270, Pg 25102, 1995). J Biol Chem 1996, 271:1250. Simske JS, Kaech SM, Harp SA, Kim SK: LET-23 Receptor • • Localization by the Cell Junction Protein LIN-7 During C. elegans Vulval Induction. Cell 1996, 85:195-204. [42]. Sivilotti L, Colquhoun D: Acetylcholine Receptors: Too Many Channels. Too Few Functions. Science 1995, 269:1681-1682.

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Protein translocation across the ER and ER events Related review: A p p r o a c h i n g the mechanism of protein transport across the ER m e m b r a n e (pp 4 9 9 - 5 0 4 ) Allen S, Naim HY, Bulleid NJ: Intrecellular Folding of Tissue-type Plasminogen Activator -Effects of Disulfide Bond Formation on N-linked Glycesylation and Secretion. J Biol Chem 1995, 270:4797-4804. Bacher G, Luetcke H, Jungnickel B, Rapoport TA, • D o b b e r s t e i n B: Regulation by the Ribosome of the GTPase of the Signal-recognition Particle During Protein Targeting. Nature 1996, in press. [7]. Beh CT, Rose MD: Two Redundant Systems Maintain Levels of Resident Proteins Within the Yeast Endoplasmic Reticulum. Proc Nat/Acad Sci USA 1995, 92:9820-9823. Belin D, Best S, Vassalli JD, Strub K: A Two-step Recognition of Signal Sequences Determines the Trenslocation Efficiency of Proteins. EMBO J 1996, 15:468-476. Bilge A, Warner CV, Press OW: Trenslocetion of Ricin A-chain into Proteoliposomes Reconstituted from Golgi and Endoplasmic Reticulum. J Biol Chem 1995, 270:23720-23725. Brodsky JL, Goeckeler J, Schekman R: BiP and Sec63p are Required for Both Co- and Posttranslational Protein Trenslocation into the Yeast Endoplasmic Reticulum. Proc Nat/Acad Sci USA 1995, 92:9643-9646. Bruneau N, Lombardo D: Chaperone Function of a Grp 94-relatad Protein for Folding and Transport of the Pancreatic Bile Salt-dependent Lipase. J Bio/Chem 1995, 270:13524-13533. Buchholz D, Scott P, Shastri N: Presentation Without Protaolytic Cleavage of Endogenous Precursors in the MHC Class I Antigen Processing Pathway. J Bio/ Chem 1995, 270:6515-6522. Busch R, Cloutier I, Sekaly RP, Hammerling GJ: Invariant Chain Protects Class II Histocompetibility Antigens from Binding Intact Polypeptides in the Endoplasmic Reticulum. EMBO J 1996, 15:418-428, Castano AR, Tangri S, Miller JEW, Holcombe HR, Jackson MR, Huse WD, Kronenberg M, Peterson PA: Peptide Binding and Presentation by Mouse CDI. Science 1995, 269:223-226. Chen HF, Kendall DA: Artificial Transmembrane Segments - Requirements for Stop Transfer and Polypeptide Orientation. J Bio/Chem 1995, 270:14115-14122. Cho HS, Cmnan JE: Defective Export of a periplasmic Enzyme Disrupts Regulation of Fatty Acid Synthesis. J Bio/Chem 1995, 270:4216-4219. Coleman CE, Lopes MA, Gillikin JW, Boston RS, Larkins BA: A Defective Signal Peptide in the Maize

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Phosphatidylinositol - Cloning of the GP12 Gene. J Bio/Chem 1995, 270:13029-13035. Letourneur O, Sechi S, Willettebrown J, Robertson MW, Kinet JP: Glycosylation of Human Truncated Fc Epsilon RI Alpha Chain is Necessary for Efficient Folding in the Endoplasmic Reticulum. J B/el Chem 1995, 270:8249-8256. LevitskayaJ, Coram M, Levitsky V, Imreh S, SteigerwaLdmuilen PM, Klein G, Kuri~la MG, Masucci MG: Inhibition of Antigen Processing by the Internal Repeat Region of the Epstein-Barr Virus Nuclear Antigen-1. Nature 1995, 375:685-688. Lyko F, Martoglio B, Jungniokel B, Rapoport TA, Dobberstein B: Signal Sequence Processing in Rough Microsomes. J Bio/Chain 1995, 270:19873-19878. Marks MS, Germain RN, BonifacinoJS: Transient Aggregation of Major Histocompatibility Complex Class II Chains During Assembly in Normal Spleen Cells. J Bio/Chem 1995, 270:10475-10481. Marto91io B, Hofmann MW, Brunner J, Dobberstein B: The • • Protein-conducting Channel in the Membrane of the Endoplasmic Reticulum is Open Laterally Toward the Lipid Bilayer. Cell 1995, 8 1 : 2 0 ? - 2 1 4 . [20]. Montero M, Brini M, Marsault R, Alvarez J, Sitia R, Pozzan T, Rizzuto R: Monitoring Dynamic Changes in Free Ca2+ Concentration in the Endoplasmic Reticulum of intact Cells. EMBO J 1995, 14:5467-5475, Moore SEH, BauvyC, Codogno P: Endoplasmic Reticulum-to-cytosol Transport of Free Polymannose Oligosaccharides in Permeabilized HepG2 Cells. EMBO J 1998, 14:6034-6042. Mullins C, Lu YQ, Campbell A, Fang H, Green N: A Mutation Affecting Signal Peptidase Inhibits Degradation of an Abnormal Membrane Protein in Saccharomyces cerevisiae. J Bio/ Chem 1998, 270:17139-17147, Otsu M, Urade R, Kite M, Omura F, Kikuchi M: A Possible Role of ER-60 Protease in the Degradation of Misfolded Proteins in the Endoplasmic Reticulum. J Btol Chem 1995, 270:14958-14961. Ou WJ, Bergeron JJM, Li Y, Kang CY, Thomas DY: Conformational Changes Induced in the Endop|asmic Reticulum Luminal Domain of Calnexin by Mg-ATP and Ca2+. J Bio/Chain 1995, 270:18051-18059. Panzner S, Dreier L, Hartmann E, Kostka S, Rapoport • • TA: Posttransletional Protein Transport in Yeast Reconstituted with a Purified Complex of Sac Proteins and Kar2p. Cell 1995, 01:561-570. [37]. Pease R.I, Leiper JM, Harrison GB, Scott J: Studies on the Translecation of the Amino Terminus of Apolipoprotein B into the Endoplasmic Reticulum. J Bio/Chem 1995, 270:7261-7271. Powers T, Walter P: Reciprocal Stimulation of GTP • Hydrolysisby Two Directly Interacting GTPases. Science 1995, 269:1422-1424. [14]. Ricci B, Sharp D, Orourke E, Kienz~eB, Blinderman L, Gordon D, SmithrnonroyC, Robinson G, Gregg RE, Rader DJ, Wetterau JR: A 30-amino Acid Truncation of the Microsomal Triglyceride Transfer Protein Large Subunit Disrupts its Interaction with Protein Disulfide-isomerase and Causes Abetalipoproteinemia. J Bio/Chem 1995, 270:14231-14288. Rosqvist R, HakanssonS, Forsberg A, Wolfwatz H: Functional Conservation of the Secretion and Translocetion Machinery for Virulence Proteins of Yersiniae, Salmonellae and Shigellae. EMBO J 1995, 14:4187-4195. Russ G, Esquivel E Yewdell JW, Cmsswell P, Spies T, Bennick JR: Assembly, Intracellular Localization, and Nucleotide Binding Properties of the Human Peptide Transporters TAP1 and TAP2 Expressed by Recombinant Vaccinia Viruses. J Bio/Chem 1995, 270;21312-21318. Schmitz A, Maintz M, Kehle T, Herzog V: In vivo Iodination of a Misfolded Proinsulin Reveals Co-localized Signals for Bip Binding and for Degradation in the ER, EMBO J 1995, 14:1091-1098. Simpson JC, Dascher C, Roberts LM, Lord JM, Balch WE: Ricin Cytotoxicity is Sensitive to Recycling Between the Endoplasmic Reticulum and the Golgi Complex. J Biol Chem 1995, 270:20078-20083 Sipos G, Puoti A, ConzelmannA: Biosynthesis of the Side Chain of Yeast Glycosylphosphatidylinositol Anchors is Operated by Novel Mannosylb'ansferasas Located in the Endoplasmic Reticulum and the Golgi Apparatus. J Bio/Chem 1996, 270:19709-19715. Sousa M, Parodi AJ: The Molecular Basis for the Recognition of Misfolded Glycoproteins by the UDP-GIc:glycoprotein Glucosyltransferase. EMBO J 1995, 14:4196-4203.

Sparkowski J, Anders J, Schlegel R: E50ncoprotein Retained in the Endoplasmic Reticulum/cis Golgi Still Induces PDGF Receptor Autophosphoryletion But Does not Transform Cells. EMBO J 1995, 14:3055-3063. Szczesnaskorupa E, Ahn KS, Chen CD, Doray B, Kemper B: The Cytoplasmic and N-terminal Transmembrane Domains of Cytochrome I)450 Contain Independent Signals for Retention in the Endoplasmic Reticulum. J Biol Chem 1995, 270:24327-24333. Tatu U, Hammond C, Helenius A: Folding and Oligomerization of Influenza Hemagglutinin in the ER and the Intermediate CompartmenL EMBO J 1995, 14:1340-1348. Traianedes K, Findlay DM, Martin TJ, Gillespie MT: Modulation of the Signal Recognition Particle 54-kDa Subunit (SRP54) in Rat Preosteoblasts by the Extrecellular Matrix. J Bio/Chem 1995, 270:20891-20894. Uebel S, MeyerTH, Kraas W, Kienle S, Jun9 G, Wiesmuller KH, Tampa R: Requirements for Paptide Binding to the Human Transporter Associated with Antigen Processing Revealed by Peptide Scans and Complex Peptide Libraries. J Die/Chem 1995, 270:18512-18516. Wada I, Imai S, Kai M, Sakane F, Kanoh H: Chaperone Function of Calreticulin when Expressed in the Endoplasmic Reticulum as the Membrane-anchored and Soluble Forms. J Bio/Chem 1995, 270:20298-20304. Wang CN, Hobman TC, Brindley DN: Degradation of Apolipoprotein B in Cultured Rat Hepatocytes Occurs in a Post-endoplasmic Reticulum Compartment. J Bio/Chem 1995, 270:24924-24931. Wiertz EJHJ, Jones TR, Sun L, Bogyo M, Geuze HJ, Ploegh • HL: The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol. Cell 1996, 84:769-779, [27]. Wolf PR, Ploegh HL: Antigen Presentation - DM Exchange Mechanism. Nature 1995, 376:464-465. Young JC, Andrews DW: The Signal Recognition Particle Receptor Alpha Subunit Assembles Co-transletionally on the Endoplasmic Reticulum Membrane During an MRNA-encoded Translation Pause in v/tro. EMBO J 1996, 15:172-181. Young JC, Ursini J, Legate KR, Miller JD, Walter P, Andrews DW: An Amino-terminal Domain Containing Hydrophobic and Hydrophilic Sequences Binds the Signal Recognition Particle Receptor Alpha Subunit to the Beta Subunit on the Endoplasmic Reticulum Membrane. J Bio/Chem 1995, 270:15650-15657. Yun HY, Eipper BA: Addition of an Endoplssmic Reticulum Retention/retrieval Signal Does not Block Maturation of Enzymatically Active Peptidylglycine Alpha-amidating Monooxygenase.J Bio/ Chem 1995, 270:15412-16416. Zhen L Rusiniak ME, Swank RT: The Beta Glucuronidase Propeptide Contains a Serpin-related Octamer Necessary for Complex Formation with Egasyn Esterase and for Retention Within the Endoplasmic Reticulum, J Biol Chem 1995, 270:11912-11920.

Protein import into organelles and organelle biogenesis Related reviews: B i o g e n e s i s of mitochondrial proteins (pp 5 0 5 - 5 1 2); C o n v e r g e n c e of model systems for peroxisome biogenesis (pp 51 3 - 5 1 8 ) t Amri EZ, Bonino E Ailhaud G, Abumrad NA, Grimaldi PA: Cloning of a Protein that Mediates Transcriptional Effects of Fatty Acids in Preadipocytes - Homology to Peroxisome Proliferator-activated Receptors. J Bio/Chem 1995, 270:2367-2371 Authier F, Bergeron JJM, Ou WJ, Rachubinski RA, Posner BI, Walton PA: Degradation of the Cleaved Leader Peptide of Thiolase by a Peroxisomal Proteinase. Proc Nat/Acad Sci USA 1995, 92:3859-3863 Baneyx F, Bertsch U, Kalbach CE, Vandervies SM, Soil J, GatenbyAA: Spinach Chloroplast Cpn21 Co-chaperonin Possesses Two Functional Domains Fused Together in a Toroidal Structure and Exhibits Nucleotide-dependent Binding to Plastid Chaperonin 60. J Bio/Chem 1995, 270:10695-10702. Berthold J, Bauer MF, Schneider H, Klaus C, Dietmeier • • K, Neupert W, Brunner M: The MIM Complex Mediates Preprotein Translocetion Across the

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Mitochondrial Inner Membrane and Couples it to the Mt-Hsp70/ATP Driving System. Cell 1995, 81 :1085-1093. [32]. Bilge A, Warner CV, Press OW: Translocetion of Ricin A-chain into Proteoliposomes Reconstituted from Golgi and Endoplssmic Reticulum. J Biel Chem 1995, 270:23720-23725. Bolliger L JunneT, Sehatz G, Lithgow T: Acidic Receptor Domains on Both Sides of the Outer Membrane Mediate Translocation of Precursor Proteins into Yeast Mitochondria. EMBO J 1995, 14:6318-6326, Breukink E, Nouwen N, VanraalteA, MizushimaS, Tommassen J, Dekruijff B: The C Terminus of SecA is Involved in Both Lipid Binding and SecB Binding. J Biol Chem 1995, 270:?902-7907 Brink S, Fischer K, Klosgen RB, Flugge Ul: Sorting of Nuclear Encoded Chloroplast Membrane Proteins to the Envelope and the Thylakoid Membrane. J Bio/ Chem 1995, 270:20808-20815. Cao W, Douglas MG: Biogenesis of ISP6, a small Carboxyl-terminal Anchored Protein of the Receptor Complex of the Mitochondrial Outer Membrane. J Bio/Chem 1995, 270:5674-5679. Chaddock AM, Mant A, Karnauchov I, Brink S, Herrmann RG, Klosgen RB, Robinson C: A New Type of Signal PepUde: Central Role of a Twin-arginine Motif in Transfer Signals for the ~pH-dependent Thylakoidal Protein Translocase. EMBO J 1995, 14:2715-2722. Corrales FJ, Fersht AR: The Folding of CreEL-bound Barnase as a Model for Chaperonin-mediated Protein Folding. Proc Nat/Acad Sei USA 1995, 92:5326-5330. Decrouychanel A, ElyaagoubiA, KohiyamaM, Richarme G: Reversal by GroES of the CreEL Preference from Hydrophobic Amino Acids Toward Hydrophilic Amino Acids. J Bio/Chem 1995, 270:10571-10575. Dodt G, Braverman N, Wong C, Moser A, Moser HW, e. Watkins P, Valle D, Gould SJ: Mutations in the PTS1 Receptor Cane, PXR1, Define Complementation Group 2 of the Peroxisome Biogenesis Disorders. Nat Genet 1995, 9:115-125. [23~]. Engel A. Hayerhartl MK, Goldie KN, Pfeifer G, Hegerl R, Muller S, Dasilva ACR, BaumeisterW, Hartl FU: Functional Significance of Symmetrical Versus Asymmetrical CreEL-CreES Chaperonin Complexes. Science 1995, 269:832-836. F~sch H, Guiard B, Neupert W, Stuart RA: Internal • TargetingSignal of the BCS1 Protein: a Novel Mechanism of Import into Mitochondria. EMBO J 1996, 15:479-487. [57]. Fransen M, Brees C, Baumgart E, VanhoorenJC, Baes • M, Mannaerts GP, Van Veldhoven P: Identification and Characterization of the Putative Human Peroxisomal C-terminal Targeting Signal Import Receptor. J Biol Chem 1995, 270:7731-7736. [33~]. Gartner F, Bomer U, Guiard B, Planner N: The Sorting Signal of Cytochrome B(2) Promotes Early Divergence from the General Mitochondrial Import Pathway and Restricts the Unfoldase Activity of Matrix Hsp70. EMBO J 1995, 14:6043-6057. Gartner F, Voos W, Queml A, Miller BR, Craig EA, Cumsky MG. Planner N: Mitochondrial Import of Subunit Va of Cytochrome C Oxidase Characterized with Yeast Mutants - Independence fTom Receptors, But Requirement for Matrix HspT0 Translocese Function. J Biol Chem 1995, 270:3788-3795, Gibbons DL, Horowitz PM: Exposure of Hydrophobic Surfaces on the Chaperonin CreEL Oligomer by Protonation or Modification of His-4Ol. J Biol Chem 1995, 270:7335-7340, Glerum DM, KoernerTJ, TzagoloffA: Cloning and Characterization of COX14, Whose Product is Required for Assembly of Yeast Cytochrome Oxidase. J Bio/Chem 1995, 270:15585-15590 Gratzer S, Lithgow T, Bauer RE, Lampin9 E, Paltauf • o F, Kohlwein SD, Haucke V, JunneT, Schatz G, Horst M: Mas37p, a Novel Receptor Subunit for Protein Import into Mitochondria. J Cell Bio11995, 129:25-34. [17]. Gruhler A, Ono H, Guiard B, Neupert W, Stuart RA: A Novel Intermediate on the Import Pathway of Cytochrome B(2) into Mitochondria: Evidence for Conservative Sorting. EMBO J 1995, 14:1349-1359, Guerra C, Roncero C, Porras A, FernandezM, Benito M: Triiodothyronine Induces the Transcription of the Uncoupling Protein Gene and Stabilizes Its MRNA in Fetal Rat Brown Adipocyte Primary Cultures. J Bio/Chem 1996, 271:2076-2081. Haas A, Scheglmann D, LazarT, Gallwitz D, Wickner W: The GTPase Ypt7p of Saccherornyces cerevisiae is Required on Both Partner Vacuoles for the Homotypic Fusion Step of Vacuole Inheritance. EMBO J 1995, 14:5258-5270. Hachiya N, Mihara K, Suda K, Horst M, Schatz G, • • Lithgow T: Reconstitution of the Initial Steps

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