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Method and apparatus for anchorage and suspension cell culture
Patent Reports Applications Multiple Stage Affhdty Process for Isolation of Specific Cells from a Cell Mixture Arlauskas et al. CellPro, Inc. US 5506130; April 9, 1996 Process for obtaining desired cells positively separated from a mixture of cells using multiple stages of affinity surfaces. Bound cells from each surface are removed and subjected to a further surface for further enrichment.
Gene Delivery Instrument with Replaceable Cartridges Heinzen et al. Agrace us US 5506125; April 9, 1996 An apparatus for acceleration of carrier particles into a target organism which may be used for rapid, sequential particle acceleration procedures which is a holder for removable mounting cartridges.
Methods of Using the a Form of the Progesterone Receptor to Screen for Antagonists of Steroid Intracellar Receptor-Mediated Transcription McDonnell Ligand Pharmaceuticals, Inc. US 5506102; April 9, 1996 Methods to screen for antagonists of steroid IR transcription as mediated by the PR-A isoform of the progesterone receptor. Such a cell-based method includes a cell in which PR-A is transcriptionally inactive containing asteroid 1R other than PR, PR-A, and a reporter vector that includes a promoter which is transcriptionally active in the presence of the steroid R and an activator of said steroid IR, but is substantially transcriptionally inactive in the presence of PR-A.
Hybridoma Producing Monoclonal Antibody F4 Which Speclflcally Binds to Multidrug Resistant P-Glycoprotein and Assays for Detection of P-Glycoprotein Chu et al. Health Research, Inc. US 5503984; April 2, 1996 A unique monoclonal antibody against P-glycoprotein. The monoclonal antibody has the surprising property of reacting to a soluble form of P-glycoprotein.
Split Ubiquitin Protein Sensor Johnsson et al. California Institute of Technology US 5503977; April 2, 1996 Compositions and methods useful for studying interactions between proteins. An N-terminal subdomain and a c-terminal subdomain of ubiquitin are linked to a pair of proteins or peptides to be
72
Enzyme Microb. Technol.,
1997, vol. 21, July
examined for their ability to interact. When contacted with one another, a quasi-native ubiquitin moiety is reconstituted provided that the protein or peptide pair do, in fact, interact with one another.
Method and Apparatus for Anchorage and Suspension Cell Culture Freedman et al. New Brunswick Scientific Co., Inc. US 5501971; March 26, 1996 A method and apparatus for cultivating anchorage and nonanchorage cells in a reactor. A reactor includes a basket-type packed bed and an internal recirculation device. The basket includes a top and bottom protion for allowing medium to flow uniformly through the basket. Medium flows downwardly from the top of the basket through the basket for providing gentle flow and preventing removal of cells from the carrier.
Determination of Potassium Ions in Fluids Berry et al. Boehringer Mannheim GmbH US 5501958; March 26, 1996 A process and a reagent for the determination of ions in fluids wherein the influence of these ions on the activity of an enzyme is measured. The ions, for example, are sodium, potassium, calcium, magnesium, manganese, lithium, lead, zinc, copper, iron, or other heavy metals or nonmetallic ions comprising chloride, bicarbonate, protons, ammonium, and substances that give rise to ammonium. The enzymes which are used may be a transferase, a hydrodase, an oxidoreductase, or a lyase.
Stabilized Hepatitis B E Antigen Suitable for Immunoassays Hicklin et al. ImClone Systems, Inc. US 5501948; M ch 26, 1996 Methods and mat3 rials for producing hepatitis virus HBe antigenic proteins useful in immunoassays without the necessity of maintaining these proteins in denaturing environments.
Mammalian
cells
Biochemical Process for Growing Living Cells by Measuring the Amount of Nutrient Added to the Reaction Medium Andrews et al. Applied Power Concepts, Inc. US 5506117; April 9, 1996 A process for growing living cellular material in a reaction zone having a membrane in contact with an aqueous medium. The rate at which nutrient is fed to the reaction zone is altered based on the determination of concentration of nutrient components as required to optimize the process.
Gene Delivery Instrument with Replaceable Cartridges Heinzen et al. Agrace us US 5506125; April 9, 1996 An apparatus for acceleration of carrier particles into a target organism which may be used for rapid, sequential particle acceleration procedures which is a holder for removable mounting cartridges.
Methods of Using the a Form of the Progesterone Receptor to Screen for Antagonists of Steroid Intracellar Receptor-Mediated Transcription McDonnell Ligand Pharmaceuticals, Inc. US 5506102; April 9, 1996 Methods to screen for antagonists of steroid IR transcription as mediated by the PR-A isoform of the progesterone receptor. Such a cell-based method includes a cell in which PR-A is transcriptionally inactive containing asteroid 1R other than PR, PR-A, and a reporter vector that includes a promoter which is transcriptionally active in the presence of the steroid R and an activator of said steroid IR, but is substantially transcriptionally inactive in the presence of PR-A.
Hybridoma Producing Monoclonal Antibody F4 Which Speclflcally Binds to Multidrug Resistant P-Glycoprotein and Assays for Detection of P-Glycoprotein Chu et al. Health Research, Inc. US 5503984; April 2, 1996 A unique monoclonal antibody against P-glycoprotein. The monoclonal antibody has the surprising property of reacting to a soluble form of P-glycoprotein.
Split Ubiquitin Protein Sensor Johnsson et al. California Institute of Technology US 5503977; April 2, 1996 Compositions and methods useful for studying interactions between proteins. An N-terminal subdomain and a c-terminal subdomain of ubiquitin are linked to a pair of proteins or peptides to be
72
Enzyme Microb. Technol.,
1997, vol. 21, July
examined for their ability to interact. When contacted with one another, a quasi-native ubiquitin moiety is reconstituted provided that the protein or peptide pair do, in fact, interact with one another.
Method and Apparatus for Anchorage and Suspension Cell Culture Freedman et al. New Brunswick Scientific Co., Inc. US 5501971; March 26, 1996 A method and apparatus for cultivating anchorage and nonanchorage cells in a reactor. A reactor includes a basket-type packed bed and an internal recirculation device. The basket includes a top and bottom protion for allowing medium to flow uniformly through the basket. Medium flows downwardly from the top of the basket through the basket for providing gentle flow and preventing removal of cells from the carrier.
Determination of Potassium Ions in Fluids Berry et al. Boehringer Mannheim GmbH US 5501958; March 26, 1996 A process and a reagent for the determination of ions in fluids wherein the influence of these ions on the activity of an enzyme is measured. The ions, for example, are sodium, potassium, calcium, magnesium, manganese, lithium, lead, zinc, copper, iron, or other heavy metals or nonmetallic ions comprising chloride, bicarbonate, protons, ammonium, and substances that give rise to ammonium. The enzymes which are used may be a transferase, a hydrodase, an oxidoreductase, or a lyase.
Stabilized Hepatitis B E Antigen Suitable for Immunoassays Hicklin et al. ImClone Systems, Inc. US 5501948; M ch 26, 1996 Methods and mat3 rials for producing hepatitis virus HBe antigenic proteins useful in immunoassays without the necessity of maintaining these proteins in denaturing environments.
Mammalian
cells
Biochemical Process for Growing Living Cells by Measuring the Amount of Nutrient Added to the Reaction Medium Andrews et al. Applied Power Concepts, Inc. US 5506117; April 9, 1996 A process for growing living cellular material in a reaction zone having a membrane in contact with an aqueous medium. The rate at which nutrient is fed to the reaction zone is altered based on the determination of concentration of nutrient components as required to optimize the process.