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Molecular probes—technology and medical applications
1258
Book Reviews
-the mammalian egg; -the biology of the embryo; -teratocarcinomas; -manipulation of genes and embryos; -cis/truns-acting factors during gene activation. This book has been written by eminent scientists and contains extensive bibliography with up-to-date references. It would be very useful for clinicians, research workers in molecular biology, immunologists, embryologists, geneticists and physiologists. Molecular ProbesTechnology
and Medical Applications. Edited by A. ALBERTINI,R. PAOLET~and R. A. REWELD. Published 1989 by Raven Press, New York. No. of pages: 316. ISBN: 0-88167-504-O. US$l12.50 (May, 1989). This book contains 3 big sections. The first concerns Molecular Probes in Genetic Diseases and describes new methodologies aimed at improving the detection of genetic defects at the molecular level. The second covers Molecular Probes in Infectious Diseases and focuses on the presentation of HIV studies, based on new diagnostic assays and on seroepidemiological characterization of the infection; and the third presents new exciting data on the use of monoclonal antibodies as the most useful and important tool in diagnosis, prognosis and therapy of human tumors. This book would be useful for clinicians, researchers working in the field of molecular biology, immunologists, geneticists and physiologists. Advances
in Biotechnology
of Membrane
Ion Transport,
(Serona Symposia, Vol. 51). Edited by P. L. JORGENSEN and R. VERNA.Published 1988 by Raven Press, New York. No. of pages: 276. ISBN: 0-88167-423-O. USS75.00 (May, 1989). The study of membrane transport is a very important problem in understanding the biological processes and this book is concerned with how membrane technology may be used for diagnostic and therapeutic purposes. The main chapters included are as follows: -structure and molecular mechanism of the Na,K-pump from mammalian kidney; -structural and functional modifications of erythrocyte Ca2’-ATPase by limited digestion with Calpain;
-extracellular potassium as a regulator of glycogenolysis in the cerebral cortex: studies in normal mice and in the spontaneously epileptic quaking mutant; -molecular properties of voltage-sensitive sodium and calcium channels; -the two roads to the voltage-dependent K+-channel; -Na,K-ATPase: molecular basis for the species difference in cardiac glycoside sensitivity; -nucleocytoplasmic transport: molecular characterization of the nuclear pore; -site specificity and effect of iron presence in the binding of various ovotransferrin proteolytic fragments to chick embryo red blood cells; -changes in allosteric properties of ascorbate-modified (Na +/K+)-ATPase; -NMR and ESR studies of active site structures and intermediate states of kidney Na,K-ATPase and SR Ca-ATPase; -tertiary structure of the (Ca(I1) + Mg(II))-ATPase probed by laser-excited lanthanide luminescence spectroscopy; -molecular dynamics stimulations on the role of water for the ion transport through narrow transmembrane channels; -regulation of ion transport properties of the nicotinic acetylcholine receptor channel; -permeation mechanism of the background chloride channel from rat spinal cord neurons; -proton-mediated gating of membrane fusion mediated by viral spike glycoproteins; -the role of membrane lipid and structure asymmetry on transport systems; -fusion of vesicular stomatitis virus with human red blood cell membranes: the role of phospholipid distribution; -modulation of human erythrocyte Na-pump by changes of plasma membrane lipid fluidity; -use of human red blood cells for the search of potent and specific inhibitors of ion transport mechanisms: therapeutical implications; -the effects of loop diuretics on the HCO;/Cl- anion exchanger in human red blood cells; -do Canrenone and 6,7-dihydroxylated derivatives compete with ouabain at the same on Na,K-ATPase? This book would be useful for clinicians, molecular biolouists. immunoloeists. eeneticists and ohvsioloaists. .r c
Book Reviews
-the mammalian egg; -the biology of the embryo; -teratocarcinomas; -manipulation of genes and embryos; -cis/truns-acting factors during gene activation. This book has been written by eminent scientists and contains extensive bibliography with up-to-date references. It would be very useful for clinicians, research workers in molecular biology, immunologists, embryologists, geneticists and physiologists. Molecular ProbesTechnology
and Medical Applications. Edited by A. ALBERTINI,R. PAOLET~and R. A. REWELD. Published 1989 by Raven Press, New York. No. of pages: 316. ISBN: 0-88167-504-O. US$l12.50 (May, 1989). This book contains 3 big sections. The first concerns Molecular Probes in Genetic Diseases and describes new methodologies aimed at improving the detection of genetic defects at the molecular level. The second covers Molecular Probes in Infectious Diseases and focuses on the presentation of HIV studies, based on new diagnostic assays and on seroepidemiological characterization of the infection; and the third presents new exciting data on the use of monoclonal antibodies as the most useful and important tool in diagnosis, prognosis and therapy of human tumors. This book would be useful for clinicians, researchers working in the field of molecular biology, immunologists, geneticists and physiologists. Advances
in Biotechnology
of Membrane
Ion Transport,
(Serona Symposia, Vol. 51). Edited by P. L. JORGENSEN and R. VERNA.Published 1988 by Raven Press, New York. No. of pages: 276. ISBN: 0-88167-423-O. USS75.00 (May, 1989). The study of membrane transport is a very important problem in understanding the biological processes and this book is concerned with how membrane technology may be used for diagnostic and therapeutic purposes. The main chapters included are as follows: -structure and molecular mechanism of the Na,K-pump from mammalian kidney; -structural and functional modifications of erythrocyte Ca2’-ATPase by limited digestion with Calpain;
-extracellular potassium as a regulator of glycogenolysis in the cerebral cortex: studies in normal mice and in the spontaneously epileptic quaking mutant; -molecular properties of voltage-sensitive sodium and calcium channels; -the two roads to the voltage-dependent K+-channel; -Na,K-ATPase: molecular basis for the species difference in cardiac glycoside sensitivity; -nucleocytoplasmic transport: molecular characterization of the nuclear pore; -site specificity and effect of iron presence in the binding of various ovotransferrin proteolytic fragments to chick embryo red blood cells; -changes in allosteric properties of ascorbate-modified (Na +/K+)-ATPase; -NMR and ESR studies of active site structures and intermediate states of kidney Na,K-ATPase and SR Ca-ATPase; -tertiary structure of the (Ca(I1) + Mg(II))-ATPase probed by laser-excited lanthanide luminescence spectroscopy; -molecular dynamics stimulations on the role of water for the ion transport through narrow transmembrane channels; -regulation of ion transport properties of the nicotinic acetylcholine receptor channel; -permeation mechanism of the background chloride channel from rat spinal cord neurons; -proton-mediated gating of membrane fusion mediated by viral spike glycoproteins; -the role of membrane lipid and structure asymmetry on transport systems; -fusion of vesicular stomatitis virus with human red blood cell membranes: the role of phospholipid distribution; -modulation of human erythrocyte Na-pump by changes of plasma membrane lipid fluidity; -use of human red blood cells for the search of potent and specific inhibitors of ion transport mechanisms: therapeutical implications; -the effects of loop diuretics on the HCO;/Cl- anion exchanger in human red blood cells; -do Canrenone and 6,7-dihydroxylated derivatives compete with ouabain at the same on Na,K-ATPase? This book would be useful for clinicians, molecular biolouists. immunoloeists. eeneticists and ohvsioloaists. .r c