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Molecular Structure Description
Toxicon 39 (2001) 733
Book Reviews Molecular Structure Description L.B. Kier, L.H. Hall; Academic Press, Harcourt Brace and Company, San Diego, London, New York, 1999, 239 pages plus Appendix 40 pages plus E-Calc. software on CD-ROM, hardcover Structure–activity relationship is an old challenge to scientists involved in work on biological activities, be it e.g. inhibition, or synergism of compounds, or even designing of drugs, before a synthesis has started. In the past many attempts have been made to approach a solution of these problems, most of them on an empirical basis. Success as well as failures were the results, the so-called combinatorial chemistry has made available huge numbers of compounds for biological testing. The development of useful quantitative structure–activity analyses (QSAR) and their exploitation are the essential sequel to combinatory chemistry. The authors of this book develop the electrotopical state (E-state) as a method which may explain certain properties from the electrodensity within a molecule, arising from the electronic properties of the single atoms and their binding states.
Humantoxikologie J. Oehlmann, B. Markert; Stuttgart, Wissenschaftliche Verlagsgesellschaft, 1998, 261 pages, 97 figures, 30 tables ¨ S 496.00 (in German), DM/SFR 68.00, O This book is one of those one has missed on the market, namely an understandable introduction to human toxicology for students and for beginners in this field. It is subdivided into three main chapters, the first one being devoted to general toxicology including environmental aspects of toxicity assessment as well as treatment of poisonings. The second chapter goes into detail as concerns the toxicology of the special organs giving valuable information on anatomy, physiology, and biochemistry. The third chapter is devoted to the chemistry of toxic compounds (metals, hydrocarbons, organic halo-
www.elsevier.com/locate/toxicon
The first five chapters deal with the theoretical fundamentals as well as sample calculations, the fifth chapter is on strategies of the E-state, and chapters 6–9 show applications; chapter 10, finally, is devoted to “future” directions of E-state studies. Each chapter closes with a summary and a list of references. The book contains a CD-ROM for E-calculations. This book is a very interesting introduction into this method showing the reasons for interactions between biologic active molecules, and also for constructing molecules with certain properties, i.e. strategies for drug design. It is a real progress compared to earlier attempts in this direction. It can be highly recommended for all those who are involved either in designing molecules with certain properties but also to those who want to know more about the mechanisms and reasons of interactions. G. Habermehl Department of Chemistry, Building 123, Hannover School of Veterinary Medicine, Bischofsholder Damm 15, 30173 Hannover, Germany PII: S0041-0101(00)00178-1
genated compounds, amines and azo compounds and many others), giving details on their metabolism. The figures and tables are very informative, and add much to the information. A glossary and a good subject index complete the book. I can recommend this book not only to students but also to chemists, physicians, ecologists and especially to engineers and material scientists. G. Habermehl Department of Chemistry, Building 123, Hannover School of Veterinary Medicine, Bischofsholder Damm 15, 30173 Hannover, Germany
PII: S0041-0101(00)00179-3
Book Reviews Molecular Structure Description L.B. Kier, L.H. Hall; Academic Press, Harcourt Brace and Company, San Diego, London, New York, 1999, 239 pages plus Appendix 40 pages plus E-Calc. software on CD-ROM, hardcover Structure–activity relationship is an old challenge to scientists involved in work on biological activities, be it e.g. inhibition, or synergism of compounds, or even designing of drugs, before a synthesis has started. In the past many attempts have been made to approach a solution of these problems, most of them on an empirical basis. Success as well as failures were the results, the so-called combinatorial chemistry has made available huge numbers of compounds for biological testing. The development of useful quantitative structure–activity analyses (QSAR) and their exploitation are the essential sequel to combinatory chemistry. The authors of this book develop the electrotopical state (E-state) as a method which may explain certain properties from the electrodensity within a molecule, arising from the electronic properties of the single atoms and their binding states.
Humantoxikologie J. Oehlmann, B. Markert; Stuttgart, Wissenschaftliche Verlagsgesellschaft, 1998, 261 pages, 97 figures, 30 tables ¨ S 496.00 (in German), DM/SFR 68.00, O This book is one of those one has missed on the market, namely an understandable introduction to human toxicology for students and for beginners in this field. It is subdivided into three main chapters, the first one being devoted to general toxicology including environmental aspects of toxicity assessment as well as treatment of poisonings. The second chapter goes into detail as concerns the toxicology of the special organs giving valuable information on anatomy, physiology, and biochemistry. The third chapter is devoted to the chemistry of toxic compounds (metals, hydrocarbons, organic halo-
www.elsevier.com/locate/toxicon
The first five chapters deal with the theoretical fundamentals as well as sample calculations, the fifth chapter is on strategies of the E-state, and chapters 6–9 show applications; chapter 10, finally, is devoted to “future” directions of E-state studies. Each chapter closes with a summary and a list of references. The book contains a CD-ROM for E-calculations. This book is a very interesting introduction into this method showing the reasons for interactions between biologic active molecules, and also for constructing molecules with certain properties, i.e. strategies for drug design. It is a real progress compared to earlier attempts in this direction. It can be highly recommended for all those who are involved either in designing molecules with certain properties but also to those who want to know more about the mechanisms and reasons of interactions. G. Habermehl Department of Chemistry, Building 123, Hannover School of Veterinary Medicine, Bischofsholder Damm 15, 30173 Hannover, Germany PII: S0041-0101(00)00178-1
genated compounds, amines and azo compounds and many others), giving details on their metabolism. The figures and tables are very informative, and add much to the information. A glossary and a good subject index complete the book. I can recommend this book not only to students but also to chemists, physicians, ecologists and especially to engineers and material scientists. G. Habermehl Department of Chemistry, Building 123, Hannover School of Veterinary Medicine, Bischofsholder Damm 15, 30173 Hannover, Germany
PII: S0041-0101(00)00179-3