Multiple coronary risk factors increase rate of restenosis after PTCA

,J Mol

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Cardiol22

(Supplement

IV)

(1990)

13 BRADYKININ

MODIFIES THE PRESSOR EFFECT OF PHENYLEPHRINE. A. Benetos, M. Safar, Diagnosis Center, Broussais Hospital, Paris, France. The action of the bradykinin (BK) on the pressor effect of different vasoactive In a first set of experiments bolus drugs was studied in normotensive Wistar rats. intra-arterial injetions of Phenylephrine (PhE 5 vg) were administrated before, during and after a continuous infusion of 450 ng/min of Bradykinin (group I). In was followed replacing PhE by Arginingroups II and III, the same procedure Vasopressin (AVP 200 ng) or Angiotensin II (AI1 400 ng) respectively. Without BK With BK Inhibition (n=7) PhE 30+3mmHg 11+4mmHg 64% Gr I 5 I@ 32tSmmHg -19% Gr II (n=6) AVP 200 ng 26+2mmHg 8% Gr III (n=6) AI1 400 ng 28+6mmHg 26t6nunHg table shows that BK, decreases the pressor effect of the PhE by 64% (p
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CORONARY RISK P., Wittenberg Cardiologique,

FACTORS INCREASE RATE OF RESTENOSIS 0.. Gallay P., Messner P., Puech P., HBpital Saint-Eloi, 34059 MONTPELLIEH

AFTER PTCA. Grollaau F(. cedex.

To evaluate the role of cororlary risk factors (CRF) in restenosis after PTCA. we reviewed all cases of PTCA performed in 1988 (n = ?i)Qj. Of 160 patients included, 40 had restsnosis during follow-up (25 SJ. Data collected were age, sex. family history, diabetes, hypertenslnr, cigarette smoking, lipid fractions, unstable angina at PTCA, number and type of vessels attempted. Hestenosis (R) and non-restenosis (NP) groups were comparable for all factors individually. The (R) g:ro)ip had a higher number of CRF (2 or more CRF : 88 % in tR) group versus -1 9; in (NR) group. p.co.ol), with a rate of restenosis increasing witn the number of CRF. Hypercholesterolemia and cigarette smoking represented the majnr part of these CRFs, being the mnst frequent asecciat:,:r ;c.';?: in (R) group versus 36 % in (NR) group, pCO.05). We concluded 10, restenosis shares conventional CRF with common atherosclerosis 20/ ~-ate Of restenosis is higher in the multirisk group 3O/ improvement should be expected when reducing CRFS, especially cigarette smoking and hypercholesterolemia. s.5