- Email: [email protected]
Neuroblastoma metastatic to the liver in infants
627
BOOKS
and 9 yr, with intraspinal epidermoid cysts causing spinal cord pressure with severe back and leg pain. All three of the children had previously had lumbar punctures performed at the level of the cysts. It was thought that the punctures might have been done with a nonstyletted needle. It is stated that a well-fitting stylet in the lumbar puncture needle will prevent this complication.-David L. Collins Ambulation of the Bmced Myelomeningocele Patient. L. J. &Sousa and N. Carroll. J Bone Joint Surg Am 58:112-l 18 (December), 1976. This study of 68 patients corroborates the study from Ranch0 Los Amigos. It reviewed meningocele patients, ages 20-30 yr. Although motivation, age, height. weight, and orthotic design tend to play a role in the patient’s ability to ambulate, the major determinant for ultimate ambulation in adulthood was a function of the neural segmental level of the lesion. Low lumbosacral lesions tended to be community ambulators. High lumbar lesions tend to be nonfunctional ambulators and thoracic lesions usually do not ambulate. Surgery tends to play only a minor role in altering this prognosis.-Anthonv H. Alter
at presentation. All had raised V.M.A. levels in the urine. The first patient had the right adrenal with the primary neuroblastoma removed followed by hepatic irradiation (500 rad). Subsequently V.M.A. levels fell and the patient is well 4 yr later. The second had hepatic irradiation (500 rad) without any initial improvement but one month later he began to improve. He was then given vincristine and cyclophosphamide intravenously for two successive weeks. A further course of hepatic irradiation was given (dose unspecified). The liver slowly regressed and the V.M.A. fell to normal. Two years later he had recurrent intraabdominal and hepatic disease and failed to respond to treatment. The third patient had a liver biopsy. She deteriorated and died two weeks later. Autopsy showed spread from a left adrenal neuroblastoma to liver, pancreas, paraaortic nodes and vertebral bone marrow as well as infiltration into the left kidney. The fourth was treated with fortnightly intravenous vincristine and cyclophosphamide and by the sixth dose the liver had shrunk to being only just palpable. This child is well at one year of age. The results and treatment of these patients is discussed.-D. G‘. Young Curcinomotous
Tumors of the Colon and Anus in
Childhood and Adolescence: Report of 2 Cases.
NEOPLASMS Neuroblastoma Metastatic to the Liver in Infants. Jane V. Bond. Arch Dis Child 51:879-882
(November), 1976. Four infants in whom a diagnosis of secondary neuroblastoma causing rapid hepatic enlargement was made are described. In three the primary tumor was in the adrenal gland and in the fourth the primary tumor was not identified. The age of the patients was from 8-16 wk
BOOKS
A. Ottolenghi, G. Rosa, and E. Boggio. chir 19:384-389, 1976.
Z Kinder-
Two patients 8 and I7 yr old with carcinoma of the iarge bowel and anus are presented. Reviewing the literature, only 12 malignant tumors of the anus were found. Neoplasms of the large bowel are two to three times as frequent as those of the anus. Mucous-producing adenocarcinomas are the most frequent ones. Survival is usually less than 6 mo.--Karl-f&wig Waag
OF INTEREST
Pediatric and Adolescent Gynecology. By S. Jean Herriot Emans and Donald Peter Goldsfein. 195 pages, illustrated. Boston, Little, Brown, 1977. Congenital Adrenal Hyperplasia. Edited by Peter A. Lee, Leslie P. Plotnick, A Avinoam Kowarski. and Claude J. Migeon 592 pages,
illustrated. Park, 1977.
$37.50.
Baltimore.
University
Antimicrobial Drug Therapy. By Abraham I. Eraude. 218 pages. illustrated. $12.00. Philadelphia, London. Toronto. Saunders. 1976. Handbook
of Critical
Care.
Edited by James
BOOKS
and 9 yr, with intraspinal epidermoid cysts causing spinal cord pressure with severe back and leg pain. All three of the children had previously had lumbar punctures performed at the level of the cysts. It was thought that the punctures might have been done with a nonstyletted needle. It is stated that a well-fitting stylet in the lumbar puncture needle will prevent this complication.-David L. Collins Ambulation of the Bmced Myelomeningocele Patient. L. J. &Sousa and N. Carroll. J Bone Joint Surg Am 58:112-l 18 (December), 1976. This study of 68 patients corroborates the study from Ranch0 Los Amigos. It reviewed meningocele patients, ages 20-30 yr. Although motivation, age, height. weight, and orthotic design tend to play a role in the patient’s ability to ambulate, the major determinant for ultimate ambulation in adulthood was a function of the neural segmental level of the lesion. Low lumbosacral lesions tended to be community ambulators. High lumbar lesions tend to be nonfunctional ambulators and thoracic lesions usually do not ambulate. Surgery tends to play only a minor role in altering this prognosis.-Anthonv H. Alter
at presentation. All had raised V.M.A. levels in the urine. The first patient had the right adrenal with the primary neuroblastoma removed followed by hepatic irradiation (500 rad). Subsequently V.M.A. levels fell and the patient is well 4 yr later. The second had hepatic irradiation (500 rad) without any initial improvement but one month later he began to improve. He was then given vincristine and cyclophosphamide intravenously for two successive weeks. A further course of hepatic irradiation was given (dose unspecified). The liver slowly regressed and the V.M.A. fell to normal. Two years later he had recurrent intraabdominal and hepatic disease and failed to respond to treatment. The third patient had a liver biopsy. She deteriorated and died two weeks later. Autopsy showed spread from a left adrenal neuroblastoma to liver, pancreas, paraaortic nodes and vertebral bone marrow as well as infiltration into the left kidney. The fourth was treated with fortnightly intravenous vincristine and cyclophosphamide and by the sixth dose the liver had shrunk to being only just palpable. This child is well at one year of age. The results and treatment of these patients is discussed.-D. G‘. Young Curcinomotous
Tumors of the Colon and Anus in
Childhood and Adolescence: Report of 2 Cases.
NEOPLASMS Neuroblastoma Metastatic to the Liver in Infants. Jane V. Bond. Arch Dis Child 51:879-882
(November), 1976. Four infants in whom a diagnosis of secondary neuroblastoma causing rapid hepatic enlargement was made are described. In three the primary tumor was in the adrenal gland and in the fourth the primary tumor was not identified. The age of the patients was from 8-16 wk
BOOKS
A. Ottolenghi, G. Rosa, and E. Boggio. chir 19:384-389, 1976.
Z Kinder-
Two patients 8 and I7 yr old with carcinoma of the iarge bowel and anus are presented. Reviewing the literature, only 12 malignant tumors of the anus were found. Neoplasms of the large bowel are two to three times as frequent as those of the anus. Mucous-producing adenocarcinomas are the most frequent ones. Survival is usually less than 6 mo.--Karl-f&wig Waag
OF INTEREST
Pediatric and Adolescent Gynecology. By S. Jean Herriot Emans and Donald Peter Goldsfein. 195 pages, illustrated. Boston, Little, Brown, 1977. Congenital Adrenal Hyperplasia. Edited by Peter A. Lee, Leslie P. Plotnick, A Avinoam Kowarski. and Claude J. Migeon 592 pages,
illustrated. Park, 1977.
$37.50.
Baltimore.
University
Antimicrobial Drug Therapy. By Abraham I. Eraude. 218 pages. illustrated. $12.00. Philadelphia, London. Toronto. Saunders. 1976. Handbook
of Critical
Care.
Edited by James