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Orbital Metastatic Neuroblastoma
Ophthalmology Volume 123, Number 8, August 2016 Funded by the US Centers for Disease Control and Prevention (Grant Number 1U58DP004060). The sponsor or funding organization participated in the preparation, review, and approval of the manuscript. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the US Centers for Disease Control and Prevention. Lumenis Inc. (San Jose, CA) donated the Selecta Duet laser platform. Author Contributions: Conception and design: Crews, Saaddine, Henderer, Hark, Katz Data collection: Waisbourd, Pruzan, Johnson, Ugorets, Henderer Analysis and interpretation: Waisbourd, Pruzan, Johnson, Ugorets, Hark, Katz
Obtained funding: Katz, Hark Manuscript preparation, approval, and overall responsibility: Waisbourd, Pruzan, Johnson, Ugorets, Crews, Saaddine, Henderer Hark, Katz Abbreviations and Acronyms: IOP ¼ intraocular pressure; LPI ¼ laser peripheral iridotomy; OAG ¼ open-angle glaucoma; PACG ¼ primary angle-closure glaucoma; POAG ¼ primary open-angle glaucoma; SLT ¼ selective laser trabeculoplasty. Correspondence: Michael Waisbourd, MD, Glaucoma Research Center, Wills Eye Hospital, 840 Walnut Street, Philadelphia, PA 19107. E-mail: MWaisbourd@ willseye.org.
Pictures & Perspectives Orbital Metastatic Neuroblastoma A 5-year-old boy presented with painless right-sided proptosis, inferomedial globe dystopia, and decreased supraduction for 2 months from a superolateral periorbital mass (Fig 1A). Orbital computed tomography revealed an ill-defined lytic mass centered in the right zygoma with both intra- and extraorbital extension (Fig 1B). Incisional biopsy displayed sheets and nests of a small blue cell tumor infiltrating the bone marrow space with areas of hemorrhage and cystic formation consistent with metastatic neuroblastoma (Fig 1C). Systemic work up revealed diffusely metastatic disease with a paraspinal primary location.
JOSHUA KURIAN, BA1 N. NEIL CHEN, MD, PHD2 ROMAN SHINDER, MD, FACS1 1 Ophthalmology, State University of New York (SUNY), Downstate Medical Center, Brooklyn, New York; 2Pathology, SUNY Downstate Medical Center, Brooklyn, New York
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Obtained funding: Katz, Hark Manuscript preparation, approval, and overall responsibility: Waisbourd, Pruzan, Johnson, Ugorets, Crews, Saaddine, Henderer Hark, Katz Abbreviations and Acronyms: IOP ¼ intraocular pressure; LPI ¼ laser peripheral iridotomy; OAG ¼ open-angle glaucoma; PACG ¼ primary angle-closure glaucoma; POAG ¼ primary open-angle glaucoma; SLT ¼ selective laser trabeculoplasty. Correspondence: Michael Waisbourd, MD, Glaucoma Research Center, Wills Eye Hospital, 840 Walnut Street, Philadelphia, PA 19107. E-mail: MWaisbourd@ willseye.org.
Pictures & Perspectives Orbital Metastatic Neuroblastoma A 5-year-old boy presented with painless right-sided proptosis, inferomedial globe dystopia, and decreased supraduction for 2 months from a superolateral periorbital mass (Fig 1A). Orbital computed tomography revealed an ill-defined lytic mass centered in the right zygoma with both intra- and extraorbital extension (Fig 1B). Incisional biopsy displayed sheets and nests of a small blue cell tumor infiltrating the bone marrow space with areas of hemorrhage and cystic formation consistent with metastatic neuroblastoma (Fig 1C). Systemic work up revealed diffusely metastatic disease with a paraspinal primary location.
JOSHUA KURIAN, BA1 N. NEIL CHEN, MD, PHD2 ROMAN SHINDER, MD, FACS1 1 Ophthalmology, State University of New York (SUNY), Downstate Medical Center, Brooklyn, New York; 2Pathology, SUNY Downstate Medical Center, Brooklyn, New York
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