- Email: [email protected]
News from the Controlled Release Society, Inc.
L~L3235,DaerfielU. IL6K;S.U.S.A. lel.(7O8)908-7971 Fax(708)8087073 A~INISIRATIVEOFFiCE:10ZOMilwaukeeAvenue.
Ih’VITATIoN To he Society has made arrangements for exhibitions during the 19th International Symposium in Orlando. At previous meetings, attendees included government personnel and research and development professionals, quality assurance/control spsciahsts, production engineers, marketing coordinators and managers from pharmaceutical, agrie& ture and cosmeti-, industries. More than 786 participants registered from all over the world, including: Canada, Europe, the Middle East, the Far East, and th,s U.S.A. Similar participation is expected during the 19th Symposium, which will provide the exhibiter a good opportunity to promote products and services related to -ontrolled release technology. The Exhibition will open on Monday, July 27, 1992, at 930 a.m. and will close ou Wednesday, July 29, at noon. The prebanquet cocktail hour, coffee breaks and poster sessions will take place in or near
the Exhibition area. The booth fee is US $16OOBtlper 8 x 10 unit (approximately 2.5 m x 3 ml, and a deposit of 50% of the total booth space fee is required if the application is received before March 16,1992. Thereafter, the application must be sent with full payment. Exhibits, advertising materials and samples are antitled to duty free and tax free entry privileges under U.S. Customs Regulations. E’orfurther information, please contact: Controlled Release Society, Administrative Office, 1026 Milwaukee Avenue, Suite 235, Deerfield, IL 60015, U.S.A. Tel: (708) ROS7071; Pax: (7083087073 Exhibition space is limited, and space is reserved on a first come, first serve basis, except 1991 and previous years’ exhibitors will be given priority for their preferrad space. Potential exhibitors should note that in past years, space has been sold out well in advance, preventing some companies from promoting their goods and services.
rarrperson: Professor Jindrich Kopecek
Dr. Karel Ulbricb, Institute of Macromolecular Chemistry, Czechoslovakia New Drug Release and Drug Delivery Systems based on Copolymers ofN-Substituted @¶ethhzerylamides c
Professor Helmut Ringsdorf, Johannes Gutenberg-Universitet M&XL, Germany Organization, Surface Recognition and Dynamics ofBiomemb,-aneModcls Professor Junzo Sunamoto, Kyoto University, Japan Cell Specific Liposomes in Aiotechnology and Medicine Professor David A. Tirrell, University of Massachusetts. U.S.A. Genetic .&&eeringas a Tool in Desrgning New Biomaterials and Drug DeliveqJ Systems
Professor Sung Wan Kim, University of Utah, U.S.A. Implantable, Injectable and Targetable Biodegradable Drug Delivery Systems - Ouerniew Dr. Abraham J. Domb, Nova Pharmaceutica! Corporation, U.S.A. Biodegradable Implants for Site Specific Delivery of Drugs Dr. Jorge Weller, Stanford Research International, U.S.A. The USPofPoly(ortho Esters) in the Treatment of &neer and forthe Pulsed Release of Proteins Dr. Colin G: Pitt, AMGEN, U.S.A. Polyester Delivery Systems: Delivery by Difision or Depradation .> Professor Jr02 Feijen, ?Jnivers?ty of Twenb, The Netherlands Albumin-&pa& Microspheres for the Controlled Delivery of Drugs
sy Dr. John Woodley, University of Keele,U.K. Peptidase Ensymcs ofthe GI Tract: Barriers to Peptide Delivery, but ..%tential for Controlled Release Dr. Roger Erickson. V.A. Medical Center, San Francisco, CA, U.S.A. Pe:>tidases of the SmallIntest~nal Brush Border Membrane To be announced Luminal Peptidases
Dr. Richard C. Straight, University of Utah, U.S.A. Mechanism, Issues andApplications of Photodynamic Therapy Dr. Alan Morgan, University of Toledo, U.S.A. L&h&Activated Druss fPhotosensitizori) and Drug Deliv&Systems Dr. Dan Doiron, Therapeutics, Inc., U.S.A. Light-Drug Dosimetry for Ca,noor D&ction and Therapy Special Ir.vZtedLectures Dr. William Abraham, University of Iowa, U.S.A. Deuterium NMR Study of Structures Formed by Stratum Corneum Lipids in Vitro Dr. Raman Baweja, Food and Drug Administration, U.S.A. Controlled Release Dosage Forms and TheirBiopharmaceuticaZRegulatory Assessment
301
Professor Ronald T. Borchexdt. University of Kansas, U.S.A. Rational Delivery Strategies to Circumvent Physical and Metabolic Barriers in the OralAbsorption ofPeptides Professor Daan J.A. Crommelin, University of Utrecht, The Netherlands Targeting ofDrugs with ImmunolipoSOl7ES
Professor Ruth Duncan, University of Keele, U.K. Design of Polymeric Drug-Carriers for Use as Lung-Specific Delivery Systems Professor William I. Higxhi, University of Utah,U.S.A. Mechanistic Studies of Skin Permcation Enhancement Employing the NormalACkanols Professor Rakesh K. Jain, Harvard University. U.S.A. Deiiky of Therapeutic Agents to Solid Tumors: Physiological Barriers and
strategtis Dr. Kazunori Kataoka, Science University of Tokvo. Jaoan Pol&&& Micelles as Novel Carriers forAnti-CancerAgents Professor Hans P. Merkle, Swiss Federal Institute of Technology, S&tzerland Epitkelial Peptide Delivery: Chances and Risks ofNasal andBuccalAbsorpttan Enhancement Professor Nicholas A. Peppas, Purdue University, U.S.A. Mechanisms of Peptide and Protein Transport in Hydrogek Dr. Gregory J. Russell-Jones, Biotech Australia, Australia Vitamin BlZDrug Delivery: A Taste of the Future in Oral Delivery
Dr. Ronald A. Siegel, University of California, San Francisco, U.S.A. ModelingApproaches to Design of aMechanockemical insulin Pump Dr. Philip M. Wallace, Bristol-Myers Squibb, U.S.A. Controlled Release ofDrugs by Targeted Enzymes Dr. Glynn Wilson, SmithKline Beecham, U.S.A. Biological Barriers to the Pulmonary 4bsorption of Peptides and Proteins ~~~Co~su~~r~oduc~
(Susan Cady, American Cyanamid, Organizer) Mr. William J, Connick, Jr., U.S. Department of Agriculture, U.S.A. Pesta: New Formulations for Release of Biopesticides Dr. Charles Garrison. Pro&r and Gamble, U.&A. Controlled Release of Consumer Products: Capabilities and Functions Dr. Michael J. Hageman, The Upjohn Comoanv. U.S.A. Inherent Instability of Somatotropins: A Critical Factor in Sustained Release Dosage Forms Dr. Dieter Lohmann, Ciba Geigy, Switzerland Biodegradable Polymers in Agricultural Controlled Release Systems Dr. Ed Schmitt, Landec Laboratories, U.S.A. Temperature Activated Release ofAdhesives Mr. Joel R. Zingerman, Merck Sharp & Dohme, U.S.A. ZVERMECB Sustained Release Bolus for Cattle: In Vitro and In Viva Drug Release Characteristics
CRS is approved by the American Council on Pharmaceutical Education as a provider of I ContinuingPharmaceutical Education (Pros-ramCredit No. 689-160-22-02).
Proyessor Jindrich Kopecek, Departments of Pbarmaceutics/CCCD and Bioengineering, University of Utah, Salt Lake City, Uteb34112, U.S.A. Arrangements
Chairpsrson
George Janes, IvIarinr, Test Stations, 886 Snowfall Spur, Akron, Ohio 44313, U.S.A.
’
enb Correlation ante. I%?&op Chairpeople: Kristine Knotson, Ph.D., Dept. of Pharmaceutics, Univer&ty of Utah, 421 W&am Way, &ah Lake City, UT 84163, U.S.A.; William R. Good, Ph.D., CIBA-GEIGY, 444 Saw Mill River Road, Ardsley, NY 10692, USA. Veterinary Applications
February 2, 1992: Abstract Due (Only one abstract required) March 30, 1992: Notification of action on abstracts
Chairman:
of Control-
Workshop Choirpe~son: John R. Cardinal, Ph.D., Merck, Sharp & Dohme Resear& Labs., Building 27-1, West Point, PA 19486, U.S.A.
John R. Cardinal, Ph.D. niticant and will also be reviewed.
Needs for imal Science C~~t~~~~e~ R&use Technology (Dr. Sidney Brokin, Sckering-Plough Corporation, U.S.A.1
for Grazing Animals (Dr. J. R. Cardinal, Merck Sharp & Dohme Resew& Laboratories, U.S.A.)
A review of marketing opportunities for the use of controlled release technology in the veterinary arena. Opportunities and market needs for both food producing animals and for companion animals are sig-
A review of boluses that have been developed to meet the need for long term delivery of drugs to grazing animals. Specific technologies to meet these needs for cattle and sheep will be covered.
Controlled
Release
Ruminal
Roluses
303
Control of Ectoparasites with Topical &very Sys$.ems O!ir. Kelly Smith,
BendResearch, Inc., U.S.A.)
The next area of product growth in the veterinary field may be in the application of gene therapy for growth and for disease prevention. This talk will introduce some of the new directions for research and the potential needs for delivery system technology.
Topical products have long been a mainstay in the veterinary field. Products, such as dips, spot-ons, and collars, for flea control in small animals are well known. In addition, topical products for parasite conJULY.%, 1992 trol in cattle are gaining prommnence. These ,areaswill be reviewed. Sessiora: d Release Systems: Qther Afternoon Session: Biodegradable and NonbiodegradA~p~~G~tious (Dr. Lisa Brannon-Peppas, L&y Research Laboratories, U.S.A.) able Implants and Injectables for Animal
Health Applications
(Dr.
Danny H. Lewis, Stolle Research and Development, U.S.A.1 Biodegradableand non-biodegradableimplants have been developed for numerous applications in the food animal field. Products for disease control, growth, and improved productivity have been developed and will bs reviewedin this presentation. Delivery Systems for Proteins and Peptides (Somatotropins: Ms. Susan M.
Cady, American Cyanamid, U.S.A.; Other Applications: Dr. Thomas Ferguson, Lilly Research Laboratories, U.S.A.) Several groups have been active in the development of sustained release systems for growth hormones in swine and cattle. This is an area where the veterinary field is far ahead of the human field in the applications of controlled release technology for protein delivery. Two speakers will address these issues. Animal Health Applications of Gene Expression &the Potential Needs for Delivery &tern l’ecbnology (Dr. Roy
Smith, Merck Sha-p & Dohme Research Laboratories, U.S.A.)
Sustained release systems are being developed for a number of other applications in the veterinary field. Included among these are systems for aquaculture and vaccines. These developments will be reviewed. Experiences from FDA inspections of Produets for
Announced) An extended session on regulatory issues will be held with an invited speaker from the FDA compliance divisicn to address preapproval inspection issues in the animal health arena. Also, speakers will provide an industrial perspective. These talks will be followed by a panel discussion to review these experiences and related topics.
CRS is approved by the American Council on Pharmaceutical Education a as a provider of Continuing Pharmaceutical Education (Program Credit No. 689-l 60-92-04).
Ih’VITATIoN To he Society has made arrangements for exhibitions during the 19th International Symposium in Orlando. At previous meetings, attendees included government personnel and research and development professionals, quality assurance/control spsciahsts, production engineers, marketing coordinators and managers from pharmaceutical, agrie& ture and cosmeti-, industries. More than 786 participants registered from all over the world, including: Canada, Europe, the Middle East, the Far East, and th,s U.S.A. Similar participation is expected during the 19th Symposium, which will provide the exhibiter a good opportunity to promote products and services related to -ontrolled release technology. The Exhibition will open on Monday, July 27, 1992, at 930 a.m. and will close ou Wednesday, July 29, at noon. The prebanquet cocktail hour, coffee breaks and poster sessions will take place in or near
the Exhibition area. The booth fee is US $16OOBtlper 8 x 10 unit (approximately 2.5 m x 3 ml, and a deposit of 50% of the total booth space fee is required if the application is received before March 16,1992. Thereafter, the application must be sent with full payment. Exhibits, advertising materials and samples are antitled to duty free and tax free entry privileges under U.S. Customs Regulations. E’orfurther information, please contact: Controlled Release Society, Administrative Office, 1026 Milwaukee Avenue, Suite 235, Deerfield, IL 60015, U.S.A. Tel: (708) ROS7071; Pax: (7083087073 Exhibition space is limited, and space is reserved on a first come, first serve basis, except 1991 and previous years’ exhibitors will be given priority for their preferrad space. Potential exhibitors should note that in past years, space has been sold out well in advance, preventing some companies from promoting their goods and services.
rarrperson: Professor Jindrich Kopecek
Dr. Karel Ulbricb, Institute of Macromolecular Chemistry, Czechoslovakia New Drug Release and Drug Delivery Systems based on Copolymers ofN-Substituted @¶ethhzerylamides c
Professor Helmut Ringsdorf, Johannes Gutenberg-Universitet M&XL, Germany Organization, Surface Recognition and Dynamics ofBiomemb,-aneModcls Professor Junzo Sunamoto, Kyoto University, Japan Cell Specific Liposomes in Aiotechnology and Medicine Professor David A. Tirrell, University of Massachusetts. U.S.A. Genetic .&&eeringas a Tool in Desrgning New Biomaterials and Drug DeliveqJ Systems
Professor Sung Wan Kim, University of Utah, U.S.A. Implantable, Injectable and Targetable Biodegradable Drug Delivery Systems - Ouerniew Dr. Abraham J. Domb, Nova Pharmaceutica! Corporation, U.S.A. Biodegradable Implants for Site Specific Delivery of Drugs Dr. Jorge Weller, Stanford Research International, U.S.A. The USPofPoly(ortho Esters) in the Treatment of &neer and forthe Pulsed Release of Proteins Dr. Colin G: Pitt, AMGEN, U.S.A. Polyester Delivery Systems: Delivery by Difision or Depradation .> Professor Jr02 Feijen, ?Jnivers?ty of Twenb, The Netherlands Albumin-&pa& Microspheres for the Controlled Delivery of Drugs
sy Dr. John Woodley, University of Keele,U.K. Peptidase Ensymcs ofthe GI Tract: Barriers to Peptide Delivery, but ..%tential for Controlled Release Dr. Roger Erickson. V.A. Medical Center, San Francisco, CA, U.S.A. Pe:>tidases of the SmallIntest~nal Brush Border Membrane To be announced Luminal Peptidases
Dr. Richard C. Straight, University of Utah, U.S.A. Mechanism, Issues andApplications of Photodynamic Therapy Dr. Alan Morgan, University of Toledo, U.S.A. L&h&Activated Druss fPhotosensitizori) and Drug Deliv&Systems Dr. Dan Doiron, Therapeutics, Inc., U.S.A. Light-Drug Dosimetry for Ca,noor D&ction and Therapy Special Ir.vZtedLectures Dr. William Abraham, University of Iowa, U.S.A. Deuterium NMR Study of Structures Formed by Stratum Corneum Lipids in Vitro Dr. Raman Baweja, Food and Drug Administration, U.S.A. Controlled Release Dosage Forms and TheirBiopharmaceuticaZRegulatory Assessment
301
Professor Ronald T. Borchexdt. University of Kansas, U.S.A. Rational Delivery Strategies to Circumvent Physical and Metabolic Barriers in the OralAbsorption ofPeptides Professor Daan J.A. Crommelin, University of Utrecht, The Netherlands Targeting ofDrugs with ImmunolipoSOl7ES
Professor Ruth Duncan, University of Keele, U.K. Design of Polymeric Drug-Carriers for Use as Lung-Specific Delivery Systems Professor William I. Higxhi, University of Utah,U.S.A. Mechanistic Studies of Skin Permcation Enhancement Employing the NormalACkanols Professor Rakesh K. Jain, Harvard University. U.S.A. Deiiky of Therapeutic Agents to Solid Tumors: Physiological Barriers and
strategtis Dr. Kazunori Kataoka, Science University of Tokvo. Jaoan Pol&&& Micelles as Novel Carriers forAnti-CancerAgents Professor Hans P. Merkle, Swiss Federal Institute of Technology, S&tzerland Epitkelial Peptide Delivery: Chances and Risks ofNasal andBuccalAbsorpttan Enhancement Professor Nicholas A. Peppas, Purdue University, U.S.A. Mechanisms of Peptide and Protein Transport in Hydrogek Dr. Gregory J. Russell-Jones, Biotech Australia, Australia Vitamin BlZDrug Delivery: A Taste of the Future in Oral Delivery
Dr. Ronald A. Siegel, University of California, San Francisco, U.S.A. ModelingApproaches to Design of aMechanockemical insulin Pump Dr. Philip M. Wallace, Bristol-Myers Squibb, U.S.A. Controlled Release ofDrugs by Targeted Enzymes Dr. Glynn Wilson, SmithKline Beecham, U.S.A. Biological Barriers to the Pulmonary 4bsorption of Peptides and Proteins ~~~Co~su~~r~oduc~
(Susan Cady, American Cyanamid, Organizer) Mr. William J, Connick, Jr., U.S. Department of Agriculture, U.S.A. Pesta: New Formulations for Release of Biopesticides Dr. Charles Garrison. Pro&r and Gamble, U.&A. Controlled Release of Consumer Products: Capabilities and Functions Dr. Michael J. Hageman, The Upjohn Comoanv. U.S.A. Inherent Instability of Somatotropins: A Critical Factor in Sustained Release Dosage Forms Dr. Dieter Lohmann, Ciba Geigy, Switzerland Biodegradable Polymers in Agricultural Controlled Release Systems Dr. Ed Schmitt, Landec Laboratories, U.S.A. Temperature Activated Release ofAdhesives Mr. Joel R. Zingerman, Merck Sharp & Dohme, U.S.A. ZVERMECB Sustained Release Bolus for Cattle: In Vitro and In Viva Drug Release Characteristics
CRS is approved by the American Council on Pharmaceutical Education as a provider of I ContinuingPharmaceutical Education (Pros-ramCredit No. 689-160-22-02).
Proyessor Jindrich Kopecek, Departments of Pbarmaceutics/CCCD and Bioengineering, University of Utah, Salt Lake City, Uteb34112, U.S.A. Arrangements
Chairpsrson
George Janes, IvIarinr, Test Stations, 886 Snowfall Spur, Akron, Ohio 44313, U.S.A.
’
enb Correlation ante. I%?&op Chairpeople: Kristine Knotson, Ph.D., Dept. of Pharmaceutics, Univer&ty of Utah, 421 W&am Way, &ah Lake City, UT 84163, U.S.A.; William R. Good, Ph.D., CIBA-GEIGY, 444 Saw Mill River Road, Ardsley, NY 10692, USA. Veterinary Applications
February 2, 1992: Abstract Due (Only one abstract required) March 30, 1992: Notification of action on abstracts
Chairman:
of Control-
Workshop Choirpe~son: John R. Cardinal, Ph.D., Merck, Sharp & Dohme Resear& Labs., Building 27-1, West Point, PA 19486, U.S.A.
John R. Cardinal, Ph.D. niticant and will also be reviewed.
Needs for imal Science C~~t~~~~e~ R&use Technology (Dr. Sidney Brokin, Sckering-Plough Corporation, U.S.A.1
for Grazing Animals (Dr. J. R. Cardinal, Merck Sharp & Dohme Resew& Laboratories, U.S.A.)
A review of marketing opportunities for the use of controlled release technology in the veterinary arena. Opportunities and market needs for both food producing animals and for companion animals are sig-
A review of boluses that have been developed to meet the need for long term delivery of drugs to grazing animals. Specific technologies to meet these needs for cattle and sheep will be covered.
Controlled
Release
Ruminal
Roluses
303
Control of Ectoparasites with Topical &very Sys$.ems O!ir. Kelly Smith,
BendResearch, Inc., U.S.A.)
The next area of product growth in the veterinary field may be in the application of gene therapy for growth and for disease prevention. This talk will introduce some of the new directions for research and the potential needs for delivery system technology.
Topical products have long been a mainstay in the veterinary field. Products, such as dips, spot-ons, and collars, for flea control in small animals are well known. In addition, topical products for parasite conJULY.%, 1992 trol in cattle are gaining prommnence. These ,areaswill be reviewed. Sessiora: d Release Systems: Qther Afternoon Session: Biodegradable and NonbiodegradA~p~~G~tious (Dr. Lisa Brannon-Peppas, L&y Research Laboratories, U.S.A.) able Implants and Injectables for Animal
Health Applications
(Dr.
Danny H. Lewis, Stolle Research and Development, U.S.A.1 Biodegradableand non-biodegradableimplants have been developed for numerous applications in the food animal field. Products for disease control, growth, and improved productivity have been developed and will bs reviewedin this presentation. Delivery Systems for Proteins and Peptides (Somatotropins: Ms. Susan M.
Cady, American Cyanamid, U.S.A.; Other Applications: Dr. Thomas Ferguson, Lilly Research Laboratories, U.S.A.) Several groups have been active in the development of sustained release systems for growth hormones in swine and cattle. This is an area where the veterinary field is far ahead of the human field in the applications of controlled release technology for protein delivery. Two speakers will address these issues. Animal Health Applications of Gene Expression &the Potential Needs for Delivery &tern l’ecbnology (Dr. Roy
Smith, Merck Sha-p & Dohme Research Laboratories, U.S.A.)
Sustained release systems are being developed for a number of other applications in the veterinary field. Included among these are systems for aquaculture and vaccines. These developments will be reviewed. Experiences from FDA inspections of Produets for
Announced) An extended session on regulatory issues will be held with an invited speaker from the FDA compliance divisicn to address preapproval inspection issues in the animal health arena. Also, speakers will provide an industrial perspective. These talks will be followed by a panel discussion to review these experiences and related topics.
CRS is approved by the American Council on Pharmaceutical Education a as a provider of Continuing Pharmaceutical Education (Program Credit No. 689-l 60-92-04).