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Normative values of event-related potentials (erps) for children in manado, Indonesia
Abstracts / Journal of the Neurological Sciences 405S (2019) 116543
outpatient clinic were reviewed. 1015 of EEGs were ordered by general neurologists (70.05), 355 by epilepsy specialists (24.5%) and 79 by other departments (5.5%). Department of psychiatry was leading among other departments by one third. 281 out of 1449 EEGs were abnormal (19.4%). Only three patients had a seizure during EEG recording. Preliminary diagnosis for EEG record request were epilepsy in 829 patients (57.2%), syncope in 257 patients (17.8%), headache in 12 (0.8%), vertigo in 12 (0.8%), cognitive dysfunction in 71 (4.9%), sleep disorder in 16 (1.1%), intracranial mass lesion in 18 (1.0%), cerebrovascular diseases in 54 (3.7%), altered mental status in 26 (73.3%) and encephalitis in 15 patients (1.0%). Normal EEG recording results were 76.5% in the recordings with preliminary diagnosis of epilepsy. Abnormalities found in patients with preliminary diagnosis of epilepsy patients were sharp/spike (Interictal Epileptiform Discharges=IED) in 45.1%, focal/generalied slowing in 41.5% and background slowing in 11.8%. Overall abnormality percentage was similar in EEGs requested by either general neurologists (76.0%) or epilepsy specialists (76.9%) but not by other departments (82.1%). As a result; EEG should not be interpreted as a screening test, patients’ details and clinical features during loss of consciousness episode has a priceless importance and preliminary diagnosis should be re- and reevaluated before EEG recording request.
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Discussion The neurological involvement in lyme disease is relatively frequent (30-60%), it can cause several neural manifestations from the peripheral and central neural system. Very few cases of retrobulbar optic neuritis, papillitis, neuroretinitis and ischemic optic neuropathy have been reported in Lyme disease. Conclusion Lyme disease must be evoked and researched in any optical neuropathy for early and effective management. doi:10.1016/j.jns.2019.10.1703
WCN19-1852 Journal of the Neurological Sciences 405S (2019) 105365 Poster Session 4 Normative values of event-related potentials (erps) for children in manado, Indonesia
doi:10.1016/j.jns.2019.10.1702 R. Sidharta, A. Mawuntu, H. Khosama Faculty of Medicine Universitas Sam Ratulangi, Neurology, Manado, Indonesia
WCN19-1851 Journal of the Neurological Sciences 405S (2019) 105364 Poster Session 4 Optic neuropathy: unusual mode of revelation of lyme disease (new case report and review of literature) M. Matia, A. Bouarfab a Neurologist, Faculty of Medicine of Algiers, Tipaza, Algeria b Ophtalmologist, Hospital, Algiers, Algeria Introduction Lyme disease is an infectious disease caused by spirochete Borrelia burgdorferi, transmitted to humans by an infected tick bite. It is characterized by a large clinical polymorphism and multiystemic involvement in the literature Lyme optic neuritis is rare only a few cases have been reported. The peculiarity of our observation is the isolated involvement of the optic nerve during Lyme disease. Patients and methods We report the case of a 26-year-old female with no particular pathological history, from endemic areas. Who consults for helmet headaches with a decrease in visual acuity progressing to worsening after one week.Ophthalmologic examination revealed visual acuity at 6/10 on the left and 4/10 on the right with bilateral papillary edema stage 2. Cerebral MRI: aspect of a right optic neuritis with discrete widening of the subarachnoid spaces of the bilateral optic nerve sheaths.Medullary MRI: without abnormalities. Intraveinous Ceftriaxone antibiotherapy combined with corticosteroid therapy was followed by a rapidly favorable evolution, marked by an almost complete recovery of visual acuity (09/10) after only ten months of follow-up.
Introduction Event-related potentials (ERPs) are objective electrophysiological measuring instruments for cognitive function. The ERPs normative values have never been determined in children of our local population. We want to determine the normative values of ERPs for children in Manado, Indonesia. Methods A cross-sectional study examining auditory ERPs in 88 children from Manado. The eligibility criteria were healthy children aged 8 to 12 years old. Cognitive function was screened using pediatric minimental state examination. Subjects should have enough sleep before the examination. The values were assessed using Natus DantecTMKeypoint® Focus 6 channels machine. The results were read by an expert examiner. The median and interquartile range were used to describe the normative data across five age groups. Examined variables were the median latency and amplitude of ERPs components (N100, N200, and P300) and motor performance (reaction time, hits, omission error, and commission error). These variables were analyzed for between-group difference (age and sex). Results Median latency values of P300 at Fz, Cz, Pz, and combined leads for the youngest and the oldest ages were as follow: 347ms, 402ms, 346ms, and 373.3ms on 8 years old subjects and 394ms, 303ms, 385ms, and 362ms on 12 years old subjects. There was no significant between-group difference for age groups and sex. Conclusion We have determined the normative values of ERPs for children in Manado. Keyword: ERPs, P300, Normative values, Latency, Amplitude, Children, Indonesia doi:10.1016/j.jns.2019.10.1704
outpatient clinic were reviewed. 1015 of EEGs were ordered by general neurologists (70.05), 355 by epilepsy specialists (24.5%) and 79 by other departments (5.5%). Department of psychiatry was leading among other departments by one third. 281 out of 1449 EEGs were abnormal (19.4%). Only three patients had a seizure during EEG recording. Preliminary diagnosis for EEG record request were epilepsy in 829 patients (57.2%), syncope in 257 patients (17.8%), headache in 12 (0.8%), vertigo in 12 (0.8%), cognitive dysfunction in 71 (4.9%), sleep disorder in 16 (1.1%), intracranial mass lesion in 18 (1.0%), cerebrovascular diseases in 54 (3.7%), altered mental status in 26 (73.3%) and encephalitis in 15 patients (1.0%). Normal EEG recording results were 76.5% in the recordings with preliminary diagnosis of epilepsy. Abnormalities found in patients with preliminary diagnosis of epilepsy patients were sharp/spike (Interictal Epileptiform Discharges=IED) in 45.1%, focal/generalied slowing in 41.5% and background slowing in 11.8%. Overall abnormality percentage was similar in EEGs requested by either general neurologists (76.0%) or epilepsy specialists (76.9%) but not by other departments (82.1%). As a result; EEG should not be interpreted as a screening test, patients’ details and clinical features during loss of consciousness episode has a priceless importance and preliminary diagnosis should be re- and reevaluated before EEG recording request.
75
Discussion The neurological involvement in lyme disease is relatively frequent (30-60%), it can cause several neural manifestations from the peripheral and central neural system. Very few cases of retrobulbar optic neuritis, papillitis, neuroretinitis and ischemic optic neuropathy have been reported in Lyme disease. Conclusion Lyme disease must be evoked and researched in any optical neuropathy for early and effective management. doi:10.1016/j.jns.2019.10.1703
WCN19-1852 Journal of the Neurological Sciences 405S (2019) 105365 Poster Session 4 Normative values of event-related potentials (erps) for children in manado, Indonesia
doi:10.1016/j.jns.2019.10.1702 R. Sidharta, A. Mawuntu, H. Khosama Faculty of Medicine Universitas Sam Ratulangi, Neurology, Manado, Indonesia
WCN19-1851 Journal of the Neurological Sciences 405S (2019) 105364 Poster Session 4 Optic neuropathy: unusual mode of revelation of lyme disease (new case report and review of literature) M. Matia, A. Bouarfab a Neurologist, Faculty of Medicine of Algiers, Tipaza, Algeria b Ophtalmologist, Hospital, Algiers, Algeria Introduction Lyme disease is an infectious disease caused by spirochete Borrelia burgdorferi, transmitted to humans by an infected tick bite. It is characterized by a large clinical polymorphism and multiystemic involvement in the literature Lyme optic neuritis is rare only a few cases have been reported. The peculiarity of our observation is the isolated involvement of the optic nerve during Lyme disease. Patients and methods We report the case of a 26-year-old female with no particular pathological history, from endemic areas. Who consults for helmet headaches with a decrease in visual acuity progressing to worsening after one week.Ophthalmologic examination revealed visual acuity at 6/10 on the left and 4/10 on the right with bilateral papillary edema stage 2. Cerebral MRI: aspect of a right optic neuritis with discrete widening of the subarachnoid spaces of the bilateral optic nerve sheaths.Medullary MRI: without abnormalities. Intraveinous Ceftriaxone antibiotherapy combined with corticosteroid therapy was followed by a rapidly favorable evolution, marked by an almost complete recovery of visual acuity (09/10) after only ten months of follow-up.
Introduction Event-related potentials (ERPs) are objective electrophysiological measuring instruments for cognitive function. The ERPs normative values have never been determined in children of our local population. We want to determine the normative values of ERPs for children in Manado, Indonesia. Methods A cross-sectional study examining auditory ERPs in 88 children from Manado. The eligibility criteria were healthy children aged 8 to 12 years old. Cognitive function was screened using pediatric minimental state examination. Subjects should have enough sleep before the examination. The values were assessed using Natus DantecTMKeypoint® Focus 6 channels machine. The results were read by an expert examiner. The median and interquartile range were used to describe the normative data across five age groups. Examined variables were the median latency and amplitude of ERPs components (N100, N200, and P300) and motor performance (reaction time, hits, omission error, and commission error). These variables were analyzed for between-group difference (age and sex). Results Median latency values of P300 at Fz, Cz, Pz, and combined leads for the youngest and the oldest ages were as follow: 347ms, 402ms, 346ms, and 373.3ms on 8 years old subjects and 394ms, 303ms, 385ms, and 362ms on 12 years old subjects. There was no significant between-group difference for age groups and sex. Conclusion We have determined the normative values of ERPs for children in Manado. Keyword: ERPs, P300, Normative values, Latency, Amplitude, Children, Indonesia doi:10.1016/j.jns.2019.10.1704