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P853 Effect of Allium Sativum and Nigella Sativa ingestion on antioxidant status in healthy postmenopausal women
S656
Poster presentations / International Journal of Gynecology & Obstetrics 107S2 (2009) S413–S729
P853 Effect of Allium Sativum and Nigella Sativa ingestion on antioxidant status in healthy postmenopausal women R. Mostafa1 , Y. Mostafa2 , Z. Mirghani1 , K. Mostafa1 . 1 College of Medicine Sharjah University, 2 College of Pharmacy Suez Canal University Egypt As women’s childbearing years come to an end, she begins to experience the first signs of menopause. Unless brought by surgery, chemotherapy or other factors, physiologic menopause occurs in most women by age 50–51. Oxidative stress has been implicated in the pathogenesis of aging and menopause, and can arise through the increased production of lipid peroxides and/or a deficiency of antioxidant defense. The objective of this study is principally to investigate the antioxidant effects of garlic extract and crude black seeds consumption on blood oxidant/antioxidant status in healthy postmenopausal women. 30 healthy postmenopausal women, mean age (50.31±4.23) participated in this study. They ingested 2 garlic soft gel/day (each softgel equivalent to 1,000 mg of fresh garlic bulb), and crude black seed ground to powder in a dose of 3 grams/day for 8 weeks. Before and after this period, fasting blood samples were obtained, oxidant (Malondialdehyde) was measured in plasma and antioxidants superoxide dismutase and glutathione peroxidase activities were studied in erythrocytes. Plasma Malondialdehyde levels were found to be significantly lower but erythrocyte glutathione peroxidase and superoxide dismustase activities were significantly higher in the second samples relative to the first ones. In conclusion, our results suggest that it may be possible that improved the balance between blood oxidants and antioxidants may play a part in some of the beneficial effects of garlic extracts and crude black seeds in healthy postmenopausal women. P854 Bone mineral density and lipid profile in postmenopausal patients with osteoporosis C. Fernandes1 , C. Stephan2 , L. Pompei1 , E. Nahas2 , J. Nahas Neto2 , S. Peixoto1 . 1 ABC School of Medicine, Santo Andr´e, Brazil, 2 Medical School of S˜ ao Paulo State University (UNESP) at Botucatu, Brazil Objective: To analyze the association between bone mineral density (BMD) in the lumbar spine and femoral neck and the lipidlipoprotein profile of postmenopausal women with osteoporosis. Methods: A cross-sectional study was performed to which 351 women were included. The mean age of patients was 64.4 years. A linear correlation was performed between lumbar spine BMD and variables comprising the lipid-lipoprotein profile: total cholesterol (TC); high-density lipoprotein cholesterol (HDL-C); low-density lipoprotein cholesterol (LDL-C); and triglycerides (TG). The same procedure was performed with respect to femoral neck BMD. Time since menopause and body mass index were variables that were also evaluated. Results: In patients who had undergone menopause 10 or more years previously, a statistically significant association was found between plasma HDL-C levels and femoral neck BMD. Plasma HDL-C levels were higher in these patients. There was no association between femoral neck BMD and the other variables comprising the lipid-lipoprotein profile (TC, LDL-C or TG). Moreover, no association was found between lumbar spine BMD and the lipid-lipoprotein variables (TC, HDL-C, LDL-C or TG). Conclusion: There was a significant association between plasma HDL-C levels and femoral neck BMD only in those women who had undergone menopause more than 10 years previously.
P855 Comparative study of effects of abrupt versus progressive discontinuation of postmenopausal hormone therapy for vasomotor symptoms in climacteric women E. Cunha, C. Fernandes, L. Azevedo, L. Pompei, R. Strufaldi, M. Steiner, J. Ferreira, S. Peixoto. ABC School of Medicine, Santo Andr´e, Brazil Objective: To compare the effects of abrupt versus progressive post-menopausal hormone therapy (HT) discontinuation over the climacteric symptoms. Methods: Sixty postmenopausal women on full dosage HT were included in this prospective randomized study and were divided into 3 groups of 20 women: Group I – placebo for six months; Group II – low dosage HT (estradiol 1.0 mg + norethisterone acetate 0.5 mg) for two months followed by placebo for four months; and Group III – low dosage HT for four months followed by placebo for two months. All groups were evaluated on a bimonthly basis for a six months period, and the climacteric symptoms were quantified through the Blatt and Kupperman Menopause Index. Results: There was no statistically significant difference when comparing either the BKMI intergroups or the hot flushes alone, at baseline and at six months, when all groups were on full dosage HT and placebo, respectively. On intermediary evaluations, at two and four months, the groups appeared distinctively when comparing the total BKMI and the hot flush alone. At total BKMI evaluation it was impossible to find a statistically significant difference when comparing the placebo and low dosage groups. However, when analyzing hot flush alone, a significant statistic difference could be noticed. Conclusions: These results allow us to conclude that the return of the climacteric symptoms, particularly the hot flushes, is not related to the regimen of HT discontinuation. P856 Atrophic processes of lower urogenital tract in postmenopausal women V. Prilepskaya Thirty to forty percent of postmenopausal women have disorders caused by decrease of estrogen production. The most significant changes occur in urogenital tract. Objective: To examine the state of vagina and cervix uteri in elderly women with atrophic processes of lower urogenital tract. We have examined 163 women. Methods: The state of urogenital tract was assessed using a combination of the most informative methods of analysis: extended colposcopy, vulvoscopy, colpocytological analyses, study of pH of vaginal contents, bacterioscopic and bacteriological analyses of vaginal content and urinary sediment, analyses for STD, cytological analysis, biopsy and pathology analysis, echoscopy, immune and interferon status. Results: The most frequent clinical presentations of atrophic processes were the following: vulvodynia (itching, burning, pain, dryness, discomfort) in 88% of women, dyspareunia in 29%, dysuria and urinary incontinence in 68%, (coital) blood-tinged discharges in 5%, colpoptosis and vaginal prolapse and prolapsus uteri in 2%. Atrophic processes of lower urogenital tract were treated with the medicinal agent Ovestin (estriol). Effectiveness of the treatment was high and came to 87%. Thus the local treatment with Ovestin has a high therapeutic effect, which is manifested in the increase of proliferative process, improvements in vaginal trophism, alterations of cleanness and pH levels of vagina, and as a result in anti-inflammatory effect.
Poster presentations / International Journal of Gynecology & Obstetrics 107S2 (2009) S413–S729
P853 Effect of Allium Sativum and Nigella Sativa ingestion on antioxidant status in healthy postmenopausal women R. Mostafa1 , Y. Mostafa2 , Z. Mirghani1 , K. Mostafa1 . 1 College of Medicine Sharjah University, 2 College of Pharmacy Suez Canal University Egypt As women’s childbearing years come to an end, she begins to experience the first signs of menopause. Unless brought by surgery, chemotherapy or other factors, physiologic menopause occurs in most women by age 50–51. Oxidative stress has been implicated in the pathogenesis of aging and menopause, and can arise through the increased production of lipid peroxides and/or a deficiency of antioxidant defense. The objective of this study is principally to investigate the antioxidant effects of garlic extract and crude black seeds consumption on blood oxidant/antioxidant status in healthy postmenopausal women. 30 healthy postmenopausal women, mean age (50.31±4.23) participated in this study. They ingested 2 garlic soft gel/day (each softgel equivalent to 1,000 mg of fresh garlic bulb), and crude black seed ground to powder in a dose of 3 grams/day for 8 weeks. Before and after this period, fasting blood samples were obtained, oxidant (Malondialdehyde) was measured in plasma and antioxidants superoxide dismutase and glutathione peroxidase activities were studied in erythrocytes. Plasma Malondialdehyde levels were found to be significantly lower but erythrocyte glutathione peroxidase and superoxide dismustase activities were significantly higher in the second samples relative to the first ones. In conclusion, our results suggest that it may be possible that improved the balance between blood oxidants and antioxidants may play a part in some of the beneficial effects of garlic extracts and crude black seeds in healthy postmenopausal women. P854 Bone mineral density and lipid profile in postmenopausal patients with osteoporosis C. Fernandes1 , C. Stephan2 , L. Pompei1 , E. Nahas2 , J. Nahas Neto2 , S. Peixoto1 . 1 ABC School of Medicine, Santo Andr´e, Brazil, 2 Medical School of S˜ ao Paulo State University (UNESP) at Botucatu, Brazil Objective: To analyze the association between bone mineral density (BMD) in the lumbar spine and femoral neck and the lipidlipoprotein profile of postmenopausal women with osteoporosis. Methods: A cross-sectional study was performed to which 351 women were included. The mean age of patients was 64.4 years. A linear correlation was performed between lumbar spine BMD and variables comprising the lipid-lipoprotein profile: total cholesterol (TC); high-density lipoprotein cholesterol (HDL-C); low-density lipoprotein cholesterol (LDL-C); and triglycerides (TG). The same procedure was performed with respect to femoral neck BMD. Time since menopause and body mass index were variables that were also evaluated. Results: In patients who had undergone menopause 10 or more years previously, a statistically significant association was found between plasma HDL-C levels and femoral neck BMD. Plasma HDL-C levels were higher in these patients. There was no association between femoral neck BMD and the other variables comprising the lipid-lipoprotein profile (TC, LDL-C or TG). Moreover, no association was found between lumbar spine BMD and the lipid-lipoprotein variables (TC, HDL-C, LDL-C or TG). Conclusion: There was a significant association between plasma HDL-C levels and femoral neck BMD only in those women who had undergone menopause more than 10 years previously.
P855 Comparative study of effects of abrupt versus progressive discontinuation of postmenopausal hormone therapy for vasomotor symptoms in climacteric women E. Cunha, C. Fernandes, L. Azevedo, L. Pompei, R. Strufaldi, M. Steiner, J. Ferreira, S. Peixoto. ABC School of Medicine, Santo Andr´e, Brazil Objective: To compare the effects of abrupt versus progressive post-menopausal hormone therapy (HT) discontinuation over the climacteric symptoms. Methods: Sixty postmenopausal women on full dosage HT were included in this prospective randomized study and were divided into 3 groups of 20 women: Group I – placebo for six months; Group II – low dosage HT (estradiol 1.0 mg + norethisterone acetate 0.5 mg) for two months followed by placebo for four months; and Group III – low dosage HT for four months followed by placebo for two months. All groups were evaluated on a bimonthly basis for a six months period, and the climacteric symptoms were quantified through the Blatt and Kupperman Menopause Index. Results: There was no statistically significant difference when comparing either the BKMI intergroups or the hot flushes alone, at baseline and at six months, when all groups were on full dosage HT and placebo, respectively. On intermediary evaluations, at two and four months, the groups appeared distinctively when comparing the total BKMI and the hot flush alone. At total BKMI evaluation it was impossible to find a statistically significant difference when comparing the placebo and low dosage groups. However, when analyzing hot flush alone, a significant statistic difference could be noticed. Conclusions: These results allow us to conclude that the return of the climacteric symptoms, particularly the hot flushes, is not related to the regimen of HT discontinuation. P856 Atrophic processes of lower urogenital tract in postmenopausal women V. Prilepskaya Thirty to forty percent of postmenopausal women have disorders caused by decrease of estrogen production. The most significant changes occur in urogenital tract. Objective: To examine the state of vagina and cervix uteri in elderly women with atrophic processes of lower urogenital tract. We have examined 163 women. Methods: The state of urogenital tract was assessed using a combination of the most informative methods of analysis: extended colposcopy, vulvoscopy, colpocytological analyses, study of pH of vaginal contents, bacterioscopic and bacteriological analyses of vaginal content and urinary sediment, analyses for STD, cytological analysis, biopsy and pathology analysis, echoscopy, immune and interferon status. Results: The most frequent clinical presentations of atrophic processes were the following: vulvodynia (itching, burning, pain, dryness, discomfort) in 88% of women, dyspareunia in 29%, dysuria and urinary incontinence in 68%, (coital) blood-tinged discharges in 5%, colpoptosis and vaginal prolapse and prolapsus uteri in 2%. Atrophic processes of lower urogenital tract were treated with the medicinal agent Ovestin (estriol). Effectiveness of the treatment was high and came to 87%. Thus the local treatment with Ovestin has a high therapeutic effect, which is manifested in the increase of proliferative process, improvements in vaginal trophism, alterations of cleanness and pH levels of vagina, and as a result in anti-inflammatory effect.