Peer review report 1 on “Safety and feasibility of single-incision laparoscopic cholecystectomy in obese patients”

Peer review report 1 on “Safety and feasibility of single-incision laparoscopic cholecystectomy in obese patients”

Annals of Medicine and Surgery 13 Supplement 1 (2017) S57 Contents lists available at ScienceDirect Annals of Medicine and Surgery journal homepage:...

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Annals of Medicine and Surgery 13 Supplement 1 (2017) S57

Contents lists available at ScienceDirect

Annals of Medicine and Surgery journal homepage: www.annalsjournal.com

Peer Review Report

Peer review report 1 on “Safety and feasibility of single-incision laparoscopic cholecystectomy in obese patients” 1. Original Submission 1.1. Recommendation Minor Revision 1.2. Comments to the author The current manuscript is a case-control study of single incision laparoscopic surgery (SILS) for cholecystectomy in obese patients. 608 patients undergoing SILS cholecystectomy from 2009-2015 were included in the analysis. 38 obese patients (BMI >30) were compared to 362 normal weight patients (BMI <25). Operating times were significantly longer in the obese group; otherwise outcome parameters were comparable. The authors conclude that SILC is feasible and safe and offers good cosmetic outcomes.

DOI of published article: http://dx.doi.org/10.1016/j.amsu.2016.12.048. http://dx.doi.org/10.1016/j.amsu.2017.01.003 2049-0801

This is a potentially interesting and generally well written analysis. There are a few concerns with the present study, the most important one the rather small cohort size of 38 patients in the obese group. The authors should define clinical relevant differences in outcome and calculate the sample size required to detect this difference. The point is: is the current sample size adequate to detect clinical relevant differences, or is the study underpowered? Do the authors have any long-term data, for example regarding the incidence of incisional site hernia during follow-up? Jorg Kleeff, MD University of Liverpool, Department of Surgery, Prescot Street, Liverpool, L78XP, United Kingdom E-mail addresses: [email protected], [email protected].