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Pharmaceutical and biomedical applications of liquid chromatography
JOURNAL OF CHROMATOGRAPHY B: BIOMEDICALAPPLICATIONS
ELSEVIER
Journal of ChromatographyB, 666 (1995) 194-195
Book Review Pharmaceutical and Biomedical Applications of Liquid Chromatography, edited by C.M. Riley, W.J. Lough and I.W. Wainer, Elsevier (Pergamon), Oxford, 1994, X + 379 pp., price £ 85.00, US$ 136.00, ISBN 0 08 041009 X. This monograph is the first volume of a new series of books entitled "Progress in Pharmaceutical and Biomedical Analysis". This multiauthored book is divided into four parts, each describing a different theme. Part one (Chaps. 1-3) discusses the application of new technology to pharmaceutical and biomedical analysis. The first chapter describes the application of the emerging new technique of capillary electrophoresis. The second chapter is devoted to novel approaches of liquid chromatographic (LC) analysis of primary amines, amino acids and peptides. The third chapter of part one is a review of different approaches for the "fast" LC used for the separation of enantiomers. Part two (Chaps. 4-7) of this book is titled "Recent Developments in the Isolation of Compouqds from Biological Matrices". Chapter four describes the increasingly used technique of solid-phase extraction for sample preparation in LC analysis. Chapter five reviews the application of restricted access media to the direct analysis of biological samples. Chapter six describes the use of on-line microdialysis sampling for the LC determination of endogenous biochemicals and pharmaceuticals. The last chapter of this part deals with current multi-column approaches to chiral bioanalysis by LC. Part three of this monograph (Chaps. 8 and 9) is devoted to preparative LC of drug substances. Chapter eight describes the application and im-
SSDI 0378-4347(95)00015-1
portance of preparative LC in the discovery of new drugs. Chapter nine specifically deals with the application of preparative LC for the purification of proteins and peptides. The last part (Chaps. 10 and 11) of this book deals with the development and validation of analytical methods in pharmaceutical and biomedical research. Chapter ten describes the development of LC procedures for drug assays acceptable for regulatory control of pharmaceuticals. Finally, chapter eleven describes a comprehensive method validation protocol for drug analysis useful for drug industry. The different chapters have been written by authors who are experts in their field. There is little duplication as the subject matter of each chapter is well defined. In some cases, however, the authors have concentrated on their own work. Thus the second chapter titled "Novel approaches to LC determination of primary amines, amino acids and peptides" is essentially a comprehensive review of the use of naphthalene-2,3-dicarboxaldehyde for the LC determination of compounds containing primary amino groups. "Application of naphthalene-2,3dicarboxaldehyde for the determination of compounds containing primary amino groups" may have been a more appropriate title for this chapter. The format of the various chapters is essentially similar. However, there are differences. There
R.N. Gupta / J. Chromatogr. B 666 (1995) 194-195
is only one chapter (Microdialysis sampling) which summarizes the applications of this technique in a tabular form. Every chapter has a section of conclusions or contains a summary. The conclusions described in chapter 3 (Fast liquid chromatography) appear to be part of the text rather than a summary of the chapter. The reviews are clearly written and include references up to 1992. A number of figures of structures, chromatograms and others showing mechanistic equations have been included for clarity. There is a detailed index. Typographical errors are minimal. Print size has been selected
195
for easy reading. The book is attractively hard bound. The development of a new drug has become quite costly. Analytical laboratories of the pharmaceutical industry are playing a very important role in keeping the cost of drug development from escalating further by providing validated assays at different stages of drug development. This book is expected to be useful to the analysts in the pharmaceutical industry. Hamilton, Canada
Ram N. Gupta
ELSEVIER
Journal of ChromatographyB, 666 (1995) 194-195
Book Review Pharmaceutical and Biomedical Applications of Liquid Chromatography, edited by C.M. Riley, W.J. Lough and I.W. Wainer, Elsevier (Pergamon), Oxford, 1994, X + 379 pp., price £ 85.00, US$ 136.00, ISBN 0 08 041009 X. This monograph is the first volume of a new series of books entitled "Progress in Pharmaceutical and Biomedical Analysis". This multiauthored book is divided into four parts, each describing a different theme. Part one (Chaps. 1-3) discusses the application of new technology to pharmaceutical and biomedical analysis. The first chapter describes the application of the emerging new technique of capillary electrophoresis. The second chapter is devoted to novel approaches of liquid chromatographic (LC) analysis of primary amines, amino acids and peptides. The third chapter of part one is a review of different approaches for the "fast" LC used for the separation of enantiomers. Part two (Chaps. 4-7) of this book is titled "Recent Developments in the Isolation of Compouqds from Biological Matrices". Chapter four describes the increasingly used technique of solid-phase extraction for sample preparation in LC analysis. Chapter five reviews the application of restricted access media to the direct analysis of biological samples. Chapter six describes the use of on-line microdialysis sampling for the LC determination of endogenous biochemicals and pharmaceuticals. The last chapter of this part deals with current multi-column approaches to chiral bioanalysis by LC. Part three of this monograph (Chaps. 8 and 9) is devoted to preparative LC of drug substances. Chapter eight describes the application and im-
SSDI 0378-4347(95)00015-1
portance of preparative LC in the discovery of new drugs. Chapter nine specifically deals with the application of preparative LC for the purification of proteins and peptides. The last part (Chaps. 10 and 11) of this book deals with the development and validation of analytical methods in pharmaceutical and biomedical research. Chapter ten describes the development of LC procedures for drug assays acceptable for regulatory control of pharmaceuticals. Finally, chapter eleven describes a comprehensive method validation protocol for drug analysis useful for drug industry. The different chapters have been written by authors who are experts in their field. There is little duplication as the subject matter of each chapter is well defined. In some cases, however, the authors have concentrated on their own work. Thus the second chapter titled "Novel approaches to LC determination of primary amines, amino acids and peptides" is essentially a comprehensive review of the use of naphthalene-2,3-dicarboxaldehyde for the LC determination of compounds containing primary amino groups. "Application of naphthalene-2,3dicarboxaldehyde for the determination of compounds containing primary amino groups" may have been a more appropriate title for this chapter. The format of the various chapters is essentially similar. However, there are differences. There
R.N. Gupta / J. Chromatogr. B 666 (1995) 194-195
is only one chapter (Microdialysis sampling) which summarizes the applications of this technique in a tabular form. Every chapter has a section of conclusions or contains a summary. The conclusions described in chapter 3 (Fast liquid chromatography) appear to be part of the text rather than a summary of the chapter. The reviews are clearly written and include references up to 1992. A number of figures of structures, chromatograms and others showing mechanistic equations have been included for clarity. There is a detailed index. Typographical errors are minimal. Print size has been selected
195
for easy reading. The book is attractively hard bound. The development of a new drug has become quite costly. Analytical laboratories of the pharmaceutical industry are playing a very important role in keeping the cost of drug development from escalating further by providing validated assays at different stages of drug development. This book is expected to be useful to the analysts in the pharmaceutical industry. Hamilton, Canada
Ram N. Gupta