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Pharmacology of Intestinal Permeation
Int. J, Biochem. Vol. 18, No. I, pp. 99-102, Printed in Great Britain. All rights reserved
1986 Copyright
0020-711X:86 $3.00 to.00
BOOK REVIEWS A Guided Tour of the Living Ceil-by C. DE DUVE. Two volumes (slipcased), 423~~. 1984. Freeman, New York. $55.95.
Part I. 708~~. 1984. Springer-Verlag, Berlin. DM 580; $216. Part II. 589~~. 1984. Springer-Verlag. Berlin. DM 480; $188.
In Christmas 1976 de Duve gave the Mirsky Science lectures at Rockefeller University to 5.50 selected highschool students. These lectures have been expanded, brought up to date and published in the 19 chapters of these two volumes. The living cell is explored in a series of imaginative journeys; the extracellular structures, the cell surface, endocytosis vesicular transport, lysosomes and intracellular digestion, the cells export system, endoplasmic reticulum, Golgi apparatus and secretion. the cytoso1 and cytoplasmic organelles, glycolysis and electron transport, mi~ochondria, chloroplasts, peroxisomes, cytoplasmic movement, membranes in action, metabolic integration and regulation, the nucleus, transcription and editing of genetic material, DNA replication and repair, recombination and other genetic rearrangements, mitosis and meiosis. The two volumes are well-written, beautifully illustrated in colour, and will delight all students of living systems and bi~h~mistry~whatever their age.
Intestinal permeation refers to the process of passage of substances across the gut wall either from the lumen to the blood or lymph or vice versa. This is controlled by the permeability of the gut. These two volumes provide reviews of the following aspects of the subject. Volume I. Morphology of the intestinal mucosa; Intestinal permeability; Methods for investigating intestinal permeability; Vascular perfusion of rat small intestine for permeation and metabolism studies; Isolated membrane vesicles in the study of intestinal permeability; The transport carrier principle; Energetics of intestinal absorption; Polarity of intestinal epitheliai cells, permeability of brush border and basolateral membranes; Electrical phenomena and ion transport in the small intestine; Intestinal permeation of water; Intestinal permeability to calcium and phosphate; Protein mediated epithelial iron transfer: Intestinal absorption of heavy metals: Intestinal absorption of sugars, amino acids and peptides; Pha~acologic aspects of ~rmeability to lipids; Absorption of fat soluble vitamins, physiology and pharmacology. Volume Il. Intestinal absorption of xenobiotics: Role of digestive enzymes in the permeability of the enterocyte; The surface pH of the intestinal mucus and its significance in the permeability of organic anions; The role of the unstirred water layer in intestinal permeability; Intestinal permeation of organic bases and quarternary ammonium compounds; Role of blood flow in intestinal permeation; Hormonal effects on intestinal permeability; Influence of opiates on intestinal transport; Effect of cholera endotoxin on intestinal permeability; Aspects of bacterial endotoxins other than cholera on intestinal permeability; Mechanisms of action of laxative drugs; Action mechanism of secretagogue drugs; Use and abuse of cathartics; Intestinal permeability studies on humans. The gut is still the main route for drug administration and so its permeability and properties are of considerable importance in determining the pharmacodynamic of drug action. The present volumes with their expertly written chapters provide an excellent review of the different aspects of gut permeability and will be essential to biochemists who wish to understand the basic problems of gut permeability and to pharmacologists concerned with the passage of drugs from the gut to the tissues of the body.
Medicinal
Chemistry; a Biochemical Approacl+by T. 1985. Oxford Univ. Press, New York. $27.95 (paperback); $47.50 (hard back).
NOCJRADY.449~~.
The understanding of the mechanism of drug action and the search for new drugs is based on the nature of the interaction between the drug and the receptor site in the cell membrane. The present book deals with the molecular action of drugs on the receptor complex. The main chapters of the book are: Physicochemical principles of drug action; Receptor-effecter theories; Methods of receptor characterization: Drugs acting on neurotransmitters and their receptors: Drugs acting on hormones. neurohormones and their receptors; Non-messenger targets for drug action; Drug distribution and metabolism; Principles of drug design; Appendix A generic list of drugs; Appendix B list of drugs arranged by pharmacological activity. The book is clearly written, well-illustrated and will give the reader a better understanding of the mechanism of drug action as well as insight into the development of new drugs.
Research %--Edited
Advances in Alcohol and Drug Problems, Vol. by R. G. SMART, H. D. CAPPELL, F. B. GLASER, Y. ISRAEL,H. KALANT, R. E. POPHAM, W. SCHMIDT and E. M. SELLERS. 333~~. 1984. Plenum Press, New York. $49.50.
The review articles in this volume are as follows: Opiate tolerance and dependence; Alcohol self-administration by experimental animals; Genetics of alcoholism; Alcohol consumption and ischaemic heart disease; Heavy alcohol consumption and physical health; Assessing alcohol use by patients; Measurement of alcohol consumption; Driver impairment and alcohol linked collision; Etiologic factors in alcoholism; Treatment of non-opiate dependency; Less hazardous tobacco use as a treatment of smoking and health. Each review has a detailed bibliography with full titles of the references.
PathophysioIogy of Plasma Protein ‘~eta~lism-Edited by G. MARIANI. 402~~. 1984. Plenum Press, New York. $59.50. The regulation and control of the levels of albumin, immunoglobulins, complement proteins, acute phase proteins, fibrinogen, antithrombins, apolipoproteins AI and AI1 and tumour produced proteins are discussed in this proceedings of a symposium held in Pisa. There is emphasis on the mathematical modelling of protein metabolism, so that one could predict the levels of plasma proteins following plasmaphoresis treatment used in autoimmune diseases. In addition to chapters on the plasma proteins described above, there are reviews on lipid disorders and atherogenesis, protein-energy malnutrition and transferrins.
Pharmacology of Intestinal Permeatiou-Edited by T. 2. CSAKY. Handbook of Experimental Pharmacology, Vol. 70. 99
1986 Copyright
0020-711X:86 $3.00 to.00
BOOK REVIEWS A Guided Tour of the Living Ceil-by C. DE DUVE. Two volumes (slipcased), 423~~. 1984. Freeman, New York. $55.95.
Part I. 708~~. 1984. Springer-Verlag, Berlin. DM 580; $216. Part II. 589~~. 1984. Springer-Verlag. Berlin. DM 480; $188.
In Christmas 1976 de Duve gave the Mirsky Science lectures at Rockefeller University to 5.50 selected highschool students. These lectures have been expanded, brought up to date and published in the 19 chapters of these two volumes. The living cell is explored in a series of imaginative journeys; the extracellular structures, the cell surface, endocytosis vesicular transport, lysosomes and intracellular digestion, the cells export system, endoplasmic reticulum, Golgi apparatus and secretion. the cytoso1 and cytoplasmic organelles, glycolysis and electron transport, mi~ochondria, chloroplasts, peroxisomes, cytoplasmic movement, membranes in action, metabolic integration and regulation, the nucleus, transcription and editing of genetic material, DNA replication and repair, recombination and other genetic rearrangements, mitosis and meiosis. The two volumes are well-written, beautifully illustrated in colour, and will delight all students of living systems and bi~h~mistry~whatever their age.
Intestinal permeation refers to the process of passage of substances across the gut wall either from the lumen to the blood or lymph or vice versa. This is controlled by the permeability of the gut. These two volumes provide reviews of the following aspects of the subject. Volume I. Morphology of the intestinal mucosa; Intestinal permeability; Methods for investigating intestinal permeability; Vascular perfusion of rat small intestine for permeation and metabolism studies; Isolated membrane vesicles in the study of intestinal permeability; The transport carrier principle; Energetics of intestinal absorption; Polarity of intestinal epitheliai cells, permeability of brush border and basolateral membranes; Electrical phenomena and ion transport in the small intestine; Intestinal permeation of water; Intestinal permeability to calcium and phosphate; Protein mediated epithelial iron transfer: Intestinal absorption of heavy metals: Intestinal absorption of sugars, amino acids and peptides; Pha~acologic aspects of ~rmeability to lipids; Absorption of fat soluble vitamins, physiology and pharmacology. Volume Il. Intestinal absorption of xenobiotics: Role of digestive enzymes in the permeability of the enterocyte; The surface pH of the intestinal mucus and its significance in the permeability of organic anions; The role of the unstirred water layer in intestinal permeability; Intestinal permeation of organic bases and quarternary ammonium compounds; Role of blood flow in intestinal permeation; Hormonal effects on intestinal permeability; Influence of opiates on intestinal transport; Effect of cholera endotoxin on intestinal permeability; Aspects of bacterial endotoxins other than cholera on intestinal permeability; Mechanisms of action of laxative drugs; Action mechanism of secretagogue drugs; Use and abuse of cathartics; Intestinal permeability studies on humans. The gut is still the main route for drug administration and so its permeability and properties are of considerable importance in determining the pharmacodynamic of drug action. The present volumes with their expertly written chapters provide an excellent review of the different aspects of gut permeability and will be essential to biochemists who wish to understand the basic problems of gut permeability and to pharmacologists concerned with the passage of drugs from the gut to the tissues of the body.
Medicinal
Chemistry; a Biochemical Approacl+by T. 1985. Oxford Univ. Press, New York. $27.95 (paperback); $47.50 (hard back).
NOCJRADY.449~~.
The understanding of the mechanism of drug action and the search for new drugs is based on the nature of the interaction between the drug and the receptor site in the cell membrane. The present book deals with the molecular action of drugs on the receptor complex. The main chapters of the book are: Physicochemical principles of drug action; Receptor-effecter theories; Methods of receptor characterization: Drugs acting on neurotransmitters and their receptors: Drugs acting on hormones. neurohormones and their receptors; Non-messenger targets for drug action; Drug distribution and metabolism; Principles of drug design; Appendix A generic list of drugs; Appendix B list of drugs arranged by pharmacological activity. The book is clearly written, well-illustrated and will give the reader a better understanding of the mechanism of drug action as well as insight into the development of new drugs.
Research %--Edited
Advances in Alcohol and Drug Problems, Vol. by R. G. SMART, H. D. CAPPELL, F. B. GLASER, Y. ISRAEL,H. KALANT, R. E. POPHAM, W. SCHMIDT and E. M. SELLERS. 333~~. 1984. Plenum Press, New York. $49.50.
The review articles in this volume are as follows: Opiate tolerance and dependence; Alcohol self-administration by experimental animals; Genetics of alcoholism; Alcohol consumption and ischaemic heart disease; Heavy alcohol consumption and physical health; Assessing alcohol use by patients; Measurement of alcohol consumption; Driver impairment and alcohol linked collision; Etiologic factors in alcoholism; Treatment of non-opiate dependency; Less hazardous tobacco use as a treatment of smoking and health. Each review has a detailed bibliography with full titles of the references.
PathophysioIogy of Plasma Protein ‘~eta~lism-Edited by G. MARIANI. 402~~. 1984. Plenum Press, New York. $59.50. The regulation and control of the levels of albumin, immunoglobulins, complement proteins, acute phase proteins, fibrinogen, antithrombins, apolipoproteins AI and AI1 and tumour produced proteins are discussed in this proceedings of a symposium held in Pisa. There is emphasis on the mathematical modelling of protein metabolism, so that one could predict the levels of plasma proteins following plasmaphoresis treatment used in autoimmune diseases. In addition to chapters on the plasma proteins described above, there are reviews on lipid disorders and atherogenesis, protein-energy malnutrition and transferrins.
Pharmacology of Intestinal Permeatiou-Edited by T. 2. CSAKY. Handbook of Experimental Pharmacology, Vol. 70. 99