- Email: [email protected]
Pharmacology of intestinal permeation
978
Book Reviews
and the presentation is high. The chapters deal with spinal cord anatomy, organization, afferent inputs, synapses in the dorsal horn, synapses in the central gray matter, membrane properties of cat spinal motoneurones, dendrites and motoneuronal integration, mammalian motor units, excitatory synapses, spinal inhibition, recurrent inhibition, muscle receptors, spinal mechanisms for the control of muscle length and tension, central pattern generators in the spinal cord, spinal lemniscal pathways, dorsal horn mechanisms of pain, spinal cord and autonomic NS, local spinal cord blood flow and oxygen metabolism. The references at the end of each chapter are given with full titles of papers and there is a very extensive author index at the back of the volume so that every author cited can be easily located. The volumes provide an excellent addition to the review literature on the spinal cord. Pat~physioiogy of Plasma Protein Meta~lis~Edited by G. Mariani. 402 pp. 1984. Plenum Press, New York. $59.50. The regulation and control of the levels of albumin, immunoglobulins, complement proteins, acute phase proteins, fibrinogen, antithrombins, apolipoproteins AI and AH, and tumour produced proteins are discussed in this proceedings of a symposium held in Pisa. There is emphasis on the mathemati~i modeling of protein metabolism, so that one could predict the levels of plasma proteins following plasmaphoresis treatment used in auto-immune diseases. In addition to chapters on the plasma proteins described above, there are reviews on lipid disorders and atherogenesis, protein-energy malnutrition, and transferrins.
Cardiology: An international Perspective--Edited by E. Chazov, V. N. Smirnov and R. G. Oganov. Two volumes. 1421 pp. 1984. Plenum Press, New York. These two volumes are the published proceedings of the World Congress of Cardiology held in Moscow in 1982. The first section contains the lectures on the physiopathology of essential hypertension; control and treatment of arterial hypertension; metabolism of the ischaemic heart; calcium and cardiovascular disease; coronary artery disease in children; atherosclerosis; cardiomyopathies; thrombosis; echocardigraphy; ventricular arrhythmias; anti-arrhythmic drugs. These topics are considerably expanded in the later sections of the volumes and provide an interesting picture of the manner in which many investigators throughout the world are studying cardiovascular diseases. If you are working on this subject then the present volumes will certainly contain information of importance to you. M~icinai Chemistry; A Bioc~mieal Approach. Tbomas Nogrady. 449 pp. 1985. Oxford University Press, New York. $27.95 paperback, $47.50 hard covers. The understanding of the mechanism of drug action and the search for new drugs is based on the nature of the interaction between the drug and the receptor site in the cell membrane. The present book deals with the molecular action of drugs on the receptor complex. The main chapters of the book are; physicochemical principles of drug action; receptor-effecter theories; methods of receptor characterization; drugs acting on neurotransmitters and their receptors; drugs acting on hormones, neurohormones and their receptors; non-messenger targets for drug action; drug distribution and metabolism; principles of drug design; appendix A, generic list of drugs; appendix B, list of drugs arranged by pharmacological activity.
The book is clearly written and well illustrated and will give the reader a better understanding of the mechanisms of drug action as well as insight into the development of new drugs.
Pharmacology of Intestinal Permeatioo-Edited by T. Z. Csaky. Handbook of Experimental Pharmacology, Volume 70, parts I and II. Part I, 708 pp. 1984. Springer-Verlag, Berlin. DM 580, $216. Part Ii, 589 pp. 1984. SpringerVeriag, Berlin. DM 480, $188. Intestinal permeatian refers to the process of passage of substances across the gut wall, either from the lumen to the blood or lymph or vice versa. This is controlled by the permeability of the gut. These two volumes provide reviews of the following aspects of the subject. Volume I. Morphology of the intestinal mucosa; intestinal permeability; methods for investigating intestinal permeability; vascular perfusion of rat small intestine for permeation and metabolism studies; isolated membrane vesicles in the study of intestinal permeability; the transport carrier principle; energetics of intestinal absorption; polarity of intestinal epithelial cells, permeability of brush border and basolateral membranes; electrical phenomena and ion transport in the small intestine; intestinal permeation of water; intestinal permeability to calcium and phosphate; protein-mediated epithelial iron transfer; intestinal absorption of heavy metals; intestinal absorption of sugars, amino acids and peptides; pharmacologic aspects of permeability to lipids; absorption of fat-soluble vitamins, physiology and pharmacology. Volume II. Intestinal absorption of xenobiotics; role of digestive enzymes in the permeability of the enterocyte; the surface pH of the intestinal mucus and its significance in the permeability of organic anions; the role of the unstirred water layer in intestinal permeability; intestinal permeation of organic bases and quarternary ammonium compounds; role of blood flow in intestinal permeation; hormonal effects on intestinal permeability; influence of opiates on intestinal transport; effect of cholera endotoxin on intestinal pe~eabi~ity; aspects of bacterial endotoxins other than cholera on intestinal permeability; mechanisms of action of laxative drugs: action mechanism of secretagogue drugs; use and abuse of cathartics; intestinal permeability studies in humans. The gut is still the main route for drug administration and so its ~~eability and properties are of considerable importance in determining the pharmacod~amics of drug action. The present volumes with their expertiy written chapters provide an excellent review of the different aspects of gut permeability and will be essential to physiologists who wish to understand the basic problems of gut permeability and to pharmacologists concerned with the passage of drugs from the gut to the tissues of the body.
Dopamine Receptor AgonistsEdited by G. Poste and S. T. Crooke. 388 pp. 1984. Plenum Press, New York. $55. This is the first volume in a series of symposia on “New Horizons in Therapeutics” founded by Smith. Kline and French. The realization that dopamine (DA) was a neutotransmitter like adrenaline and noradrenahne led to a boost in DA research especially when DA was shown to be involved in Parkinson’s disease, hyperprolactinemia, certain pituitary tumors, and in the therapy of cardiovascular shock. The differentiation of different types of DA receptors and their specific antagonists promises selective treatment of those in the gut, kidney, heart and specific regions of the vascular bed.
Book Reviews
and the presentation is high. The chapters deal with spinal cord anatomy, organization, afferent inputs, synapses in the dorsal horn, synapses in the central gray matter, membrane properties of cat spinal motoneurones, dendrites and motoneuronal integration, mammalian motor units, excitatory synapses, spinal inhibition, recurrent inhibition, muscle receptors, spinal mechanisms for the control of muscle length and tension, central pattern generators in the spinal cord, spinal lemniscal pathways, dorsal horn mechanisms of pain, spinal cord and autonomic NS, local spinal cord blood flow and oxygen metabolism. The references at the end of each chapter are given with full titles of papers and there is a very extensive author index at the back of the volume so that every author cited can be easily located. The volumes provide an excellent addition to the review literature on the spinal cord. Pat~physioiogy of Plasma Protein Meta~lis~Edited by G. Mariani. 402 pp. 1984. Plenum Press, New York. $59.50. The regulation and control of the levels of albumin, immunoglobulins, complement proteins, acute phase proteins, fibrinogen, antithrombins, apolipoproteins AI and AH, and tumour produced proteins are discussed in this proceedings of a symposium held in Pisa. There is emphasis on the mathemati~i modeling of protein metabolism, so that one could predict the levels of plasma proteins following plasmaphoresis treatment used in auto-immune diseases. In addition to chapters on the plasma proteins described above, there are reviews on lipid disorders and atherogenesis, protein-energy malnutrition, and transferrins.
Cardiology: An international Perspective--Edited by E. Chazov, V. N. Smirnov and R. G. Oganov. Two volumes. 1421 pp. 1984. Plenum Press, New York. These two volumes are the published proceedings of the World Congress of Cardiology held in Moscow in 1982. The first section contains the lectures on the physiopathology of essential hypertension; control and treatment of arterial hypertension; metabolism of the ischaemic heart; calcium and cardiovascular disease; coronary artery disease in children; atherosclerosis; cardiomyopathies; thrombosis; echocardigraphy; ventricular arrhythmias; anti-arrhythmic drugs. These topics are considerably expanded in the later sections of the volumes and provide an interesting picture of the manner in which many investigators throughout the world are studying cardiovascular diseases. If you are working on this subject then the present volumes will certainly contain information of importance to you. M~icinai Chemistry; A Bioc~mieal Approach. Tbomas Nogrady. 449 pp. 1985. Oxford University Press, New York. $27.95 paperback, $47.50 hard covers. The understanding of the mechanism of drug action and the search for new drugs is based on the nature of the interaction between the drug and the receptor site in the cell membrane. The present book deals with the molecular action of drugs on the receptor complex. The main chapters of the book are; physicochemical principles of drug action; receptor-effecter theories; methods of receptor characterization; drugs acting on neurotransmitters and their receptors; drugs acting on hormones, neurohormones and their receptors; non-messenger targets for drug action; drug distribution and metabolism; principles of drug design; appendix A, generic list of drugs; appendix B, list of drugs arranged by pharmacological activity.
The book is clearly written and well illustrated and will give the reader a better understanding of the mechanisms of drug action as well as insight into the development of new drugs.
Pharmacology of Intestinal Permeatioo-Edited by T. Z. Csaky. Handbook of Experimental Pharmacology, Volume 70, parts I and II. Part I, 708 pp. 1984. Springer-Verlag, Berlin. DM 580, $216. Part Ii, 589 pp. 1984. SpringerVeriag, Berlin. DM 480, $188. Intestinal permeatian refers to the process of passage of substances across the gut wall, either from the lumen to the blood or lymph or vice versa. This is controlled by the permeability of the gut. These two volumes provide reviews of the following aspects of the subject. Volume I. Morphology of the intestinal mucosa; intestinal permeability; methods for investigating intestinal permeability; vascular perfusion of rat small intestine for permeation and metabolism studies; isolated membrane vesicles in the study of intestinal permeability; the transport carrier principle; energetics of intestinal absorption; polarity of intestinal epithelial cells, permeability of brush border and basolateral membranes; electrical phenomena and ion transport in the small intestine; intestinal permeation of water; intestinal permeability to calcium and phosphate; protein-mediated epithelial iron transfer; intestinal absorption of heavy metals; intestinal absorption of sugars, amino acids and peptides; pharmacologic aspects of permeability to lipids; absorption of fat-soluble vitamins, physiology and pharmacology. Volume II. Intestinal absorption of xenobiotics; role of digestive enzymes in the permeability of the enterocyte; the surface pH of the intestinal mucus and its significance in the permeability of organic anions; the role of the unstirred water layer in intestinal permeability; intestinal permeation of organic bases and quarternary ammonium compounds; role of blood flow in intestinal permeation; hormonal effects on intestinal permeability; influence of opiates on intestinal transport; effect of cholera endotoxin on intestinal pe~eabi~ity; aspects of bacterial endotoxins other than cholera on intestinal permeability; mechanisms of action of laxative drugs: action mechanism of secretagogue drugs; use and abuse of cathartics; intestinal permeability studies in humans. The gut is still the main route for drug administration and so its ~~eability and properties are of considerable importance in determining the pharmacod~amics of drug action. The present volumes with their expertiy written chapters provide an excellent review of the different aspects of gut permeability and will be essential to physiologists who wish to understand the basic problems of gut permeability and to pharmacologists concerned with the passage of drugs from the gut to the tissues of the body.
Dopamine Receptor AgonistsEdited by G. Poste and S. T. Crooke. 388 pp. 1984. Plenum Press, New York. $55. This is the first volume in a series of symposia on “New Horizons in Therapeutics” founded by Smith. Kline and French. The realization that dopamine (DA) was a neutotransmitter like adrenaline and noradrenahne led to a boost in DA research especially when DA was shown to be involved in Parkinson’s disease, hyperprolactinemia, certain pituitary tumors, and in the therapy of cardiovascular shock. The differentiation of different types of DA receptors and their specific antagonists promises selective treatment of those in the gut, kidney, heart and specific regions of the vascular bed.