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Phenotypic characterization and genetic mapping of the dwarf mutant m34 in maize
18.92 (10.086)
16.62 (9.578)
19 (73.1) 6 (23.1) 1 (3.8) 7 (29.2)
10 14 0 17
3 (12.0)
18 (81.8)
0 (0.0) 8 (32.0) 13 (52.0) 4 (16.0)
2 (8.3) 3 (12.5) 15 (62.5) 4 (16.7)
8.5 (3.536)
5.0 (1.789)
3.0 (2.646)
7.25 (2.500)
2 (28.6) 4 (57.1)
9 (64.3) 5 (35.7)
1 1 16 1
0 (0.0) 1 (10.0) 8 (80.0) 1 (10.0)
(5.6) (5.6) (88.9) (5.6)
AGA Abstracts
Gender Duration of disease - mean in years (SD) Ulcerative Colitis Crohn's Disease Indeterminate Colitis Endoscopic disease present Adjacent histological inflammation Current Medications Steroids Mesalamines Biologics Immunomodulators Duration of biologics mean in years (SD) Duration of immunomodulators - mean in years (SD) Location of luminal CD Ileocolonic Colonic Location of UC Proctitis Left-sided colitis Pancolitis Unknown
Healed PP - n (%) Traditional PP - n (%) Female - 16 (61.5) Male - Female - 14 (58.3) Male 10 (38.5) 10 (41.7)
(41.7) (58.3) (0.0) (81.0)
Sa1854 IMPACT OF BARIATRIC SURGERY ON THE LONG-TERM CLINICAL COURSE OF INFLAMMATORY BOWEL DISEASES Manuel Bonfim Braga Neto, Martin H. Gregory, Guilherme Piovezani Ramos, David H. Bruining, Fateh Bazerbachi, Barham K. Abu Dayyeh, Vladimir Kushnir, Laura H. Raffals, Matthew A. Ciorba, Edward V. Loftus, Parakkal Deepak Background: Our aim was to determine the impact of bariatric surgery on long-term clinical course of obese pts with IBD, either Crohn's disease (CD) or ulcerative colitis (UC). Methods: Electronic medical records from two tertiary IBD centers were reviewed using informatics search tools to identify pts with co-occurrence of an ICD-9/10 code for CD or UC and note terms of bariatric surgery (Roux-en-Y, bariatric surgery, gastroplasty, gastric bypass, gastric sleeve, duodenal switch, gastric banding) after the diagnosis of IBD. Patients with IBD and bariatric surgery (cases) were matched 1:1 for age, gender, IBD type, phenotype and location, to those with IBD without bariatric surgery (controls). Data on IBD medication usage and disease-related complications (need for steroids, hospitalizations and surgeries) were captured. Controls started follow-up at a time point in their disease similar to the disease duration in the matched case at the time of bariatric surgery. Matched cases and controls were compared for disease-related complications with McNemar's test. Results: After record review, 47 pts met inclusion criteria (18 CD and 29 UC). For the case control analysis, a total of 25 cases (12 CD and 13 UC) were included after excluding 22 pts from case series (9 UC with prior colectomy; 13 IBD cases without adequate control matching). Overall, Roux-en-Y (60%) and gastric banding (24%) were the two most common types of bariatric surgery (Table 1). Median follow-up among cases (after bariatric surgery) and controls were 7.69 and 7.89 yrs. respectively. Among cases, weight loss was recorded after bariatric surgery among pts with CD (median body mass index [BMI], 49.5 before vs. 34 after) and UC (median BMI, 43 before vs. 32.8 after). Among UC cases, extensive colitis was the predominant disease extent before bariatric surgery (61.5%). In the CD cases, the most common disease extent before bariatric surgery was ileocolonic (79%), while penetrating phenotype (41.2%) was the predominant disease behavior (Table 1). IBD-related complications were less common in cases than controls (40% vs 72%, respectively; p=0.01); specifically, in rescue corticosteroid use (24% vs 52%, respectively; p=0.02), although IBD-related surgeries were numerically lower in cases (Table 2). Among cases, one patient with CD progressed from inflammatory to stricturing phenotype while one UC patient progressed from left-sided to extensive. Among controls, 1 pt. with CD progressed from inflammatory to penetrating phenotype. Two cases and one control pt were able to discontinue biologics during followup. Conclusion: IBD pts have a lower requirement of rescue corticosteroids after weight loss from bariatric surgery. This observation requires validation in larger, prospective cohorts to study effect of weight loss on IBD disease activity and course.
Sa1855 ANALYSIS OF THE CLINICAL, GASTROSCOPIC, AND PATHOLOGICAL FEATURES OF UPPER GASTROINTESTINAL LESIONS IN CROHN'S DISEASE Miao Li, Qingfan Yang, Zi Cheng Huang, JunZhang Zhao, Kang Chao, Jian Tang, Xinjuan Fan, Honglei Chen, Yan Huang, Chujun Li, Min Zhi, Pinjin Hu, Xiang Gao Aims: With the increasing incidence of Crohn's disease (CD) of the upper gastrointestinal (UGI) tract, whether gastroscopy should be routinely performed in asymptomatic adult CD patients is controversial. We aimed to assess the prevalence of UGI involvement, determine the role of gastroscopy in the diagnosis, and assess whether UGI symptoms should be used as guidelines for gastroscopy. Methods: This cross sectional study included consecutive patients diagnosed with CD at our center between June 2017 and May 2018. gastroscopies and histological reviews were performed by designated endoscopists and pathologists. Ten specimens were obtained from six areas of the UGI tract (the esophagus, gastric body, antrum and angulus, duodenal bulb, and descending duodenum). Both demographic and clinical data were collected. Results: Among the 169 included patients, endoscopic and histological lesions suspected to be of UGI CD were found in 74 (43.79%) and 106 (62.72%) patients respectively. 7 (4.14%) patients had non-caseating granulomas, 15 (8.88%) patients had focally enhanced gastritis, and 36 (21.3%) patients had focal active gastritis. 137 (81.1%) patients had no UGI symptoms, among these, endoscopic and/or pathological abnormalities were observed in 108 (78.8%) patients. Twenty-four (75%) patients with UGI symptoms did not have any endoscopic or histological abnormalities. In total, the rates of non-caseating granulomas, focally enhanced gastritis, and focal active inflammation were significantly higher in the asymptomatic group (P=0.033). According to the endoscopic and histological features, 26 patients (15.4%) were identified having UGI CD involvement among 169 CD patients, and among these, 24 patients (17.5%) were asymptomatic, whereas 2 (6.3%) were symptomatic. We further observed that the frequency of characteristic histological lesions was significantly higher in the gastric antrum and angulus than in any other biopsy site (P= 0.028). Focally enhanced gastritis and focal active inflammation had significantly higher frequencies than non-caseating granulomas in the stomach (P<0.01). There were no significant differences in the basic data between patients with or without endoscopic or pathological abnormalities (P>0.05). Conclusion: There was a high frequency of UGI involvement in adult CD patients, irrespective of the presence or absence of UGI symptoms. Confirmable characteristic UGI lesions of CD are also common, and routine gastroscopy and biopsy may be recommended for patients suspected of having or diagnosed with CD. Focally enhanced gastritis and focal active inflammation were observed to be more common than non-caseating granulomas which may helpful in the diagnosis of CD and are worth focusing on.
S-429
AGA Abstracts
16.62 (9.578)
19 (73.1) 6 (23.1) 1 (3.8) 7 (29.2)
10 14 0 17
3 (12.0)
18 (81.8)
0 (0.0) 8 (32.0) 13 (52.0) 4 (16.0)
2 (8.3) 3 (12.5) 15 (62.5) 4 (16.7)
8.5 (3.536)
5.0 (1.789)
3.0 (2.646)
7.25 (2.500)
2 (28.6) 4 (57.1)
9 (64.3) 5 (35.7)
1 1 16 1
0 (0.0) 1 (10.0) 8 (80.0) 1 (10.0)
(5.6) (5.6) (88.9) (5.6)
AGA Abstracts
Gender Duration of disease - mean in years (SD) Ulcerative Colitis Crohn's Disease Indeterminate Colitis Endoscopic disease present Adjacent histological inflammation Current Medications Steroids Mesalamines Biologics Immunomodulators Duration of biologics mean in years (SD) Duration of immunomodulators - mean in years (SD) Location of luminal CD Ileocolonic Colonic Location of UC Proctitis Left-sided colitis Pancolitis Unknown
Healed PP - n (%) Traditional PP - n (%) Female - 16 (61.5) Male - Female - 14 (58.3) Male 10 (38.5) 10 (41.7)
(41.7) (58.3) (0.0) (81.0)
Sa1854 IMPACT OF BARIATRIC SURGERY ON THE LONG-TERM CLINICAL COURSE OF INFLAMMATORY BOWEL DISEASES Manuel Bonfim Braga Neto, Martin H. Gregory, Guilherme Piovezani Ramos, David H. Bruining, Fateh Bazerbachi, Barham K. Abu Dayyeh, Vladimir Kushnir, Laura H. Raffals, Matthew A. Ciorba, Edward V. Loftus, Parakkal Deepak Background: Our aim was to determine the impact of bariatric surgery on long-term clinical course of obese pts with IBD, either Crohn's disease (CD) or ulcerative colitis (UC). Methods: Electronic medical records from two tertiary IBD centers were reviewed using informatics search tools to identify pts with co-occurrence of an ICD-9/10 code for CD or UC and note terms of bariatric surgery (Roux-en-Y, bariatric surgery, gastroplasty, gastric bypass, gastric sleeve, duodenal switch, gastric banding) after the diagnosis of IBD. Patients with IBD and bariatric surgery (cases) were matched 1:1 for age, gender, IBD type, phenotype and location, to those with IBD without bariatric surgery (controls). Data on IBD medication usage and disease-related complications (need for steroids, hospitalizations and surgeries) were captured. Controls started follow-up at a time point in their disease similar to the disease duration in the matched case at the time of bariatric surgery. Matched cases and controls were compared for disease-related complications with McNemar's test. Results: After record review, 47 pts met inclusion criteria (18 CD and 29 UC). For the case control analysis, a total of 25 cases (12 CD and 13 UC) were included after excluding 22 pts from case series (9 UC with prior colectomy; 13 IBD cases without adequate control matching). Overall, Roux-en-Y (60%) and gastric banding (24%) were the two most common types of bariatric surgery (Table 1). Median follow-up among cases (after bariatric surgery) and controls were 7.69 and 7.89 yrs. respectively. Among cases, weight loss was recorded after bariatric surgery among pts with CD (median body mass index [BMI], 49.5 before vs. 34 after) and UC (median BMI, 43 before vs. 32.8 after). Among UC cases, extensive colitis was the predominant disease extent before bariatric surgery (61.5%). In the CD cases, the most common disease extent before bariatric surgery was ileocolonic (79%), while penetrating phenotype (41.2%) was the predominant disease behavior (Table 1). IBD-related complications were less common in cases than controls (40% vs 72%, respectively; p=0.01); specifically, in rescue corticosteroid use (24% vs 52%, respectively; p=0.02), although IBD-related surgeries were numerically lower in cases (Table 2). Among cases, one patient with CD progressed from inflammatory to stricturing phenotype while one UC patient progressed from left-sided to extensive. Among controls, 1 pt. with CD progressed from inflammatory to penetrating phenotype. Two cases and one control pt were able to discontinue biologics during followup. Conclusion: IBD pts have a lower requirement of rescue corticosteroids after weight loss from bariatric surgery. This observation requires validation in larger, prospective cohorts to study effect of weight loss on IBD disease activity and course.
Sa1855 ANALYSIS OF THE CLINICAL, GASTROSCOPIC, AND PATHOLOGICAL FEATURES OF UPPER GASTROINTESTINAL LESIONS IN CROHN'S DISEASE Miao Li, Qingfan Yang, Zi Cheng Huang, JunZhang Zhao, Kang Chao, Jian Tang, Xinjuan Fan, Honglei Chen, Yan Huang, Chujun Li, Min Zhi, Pinjin Hu, Xiang Gao Aims: With the increasing incidence of Crohn's disease (CD) of the upper gastrointestinal (UGI) tract, whether gastroscopy should be routinely performed in asymptomatic adult CD patients is controversial. We aimed to assess the prevalence of UGI involvement, determine the role of gastroscopy in the diagnosis, and assess whether UGI symptoms should be used as guidelines for gastroscopy. Methods: This cross sectional study included consecutive patients diagnosed with CD at our center between June 2017 and May 2018. gastroscopies and histological reviews were performed by designated endoscopists and pathologists. Ten specimens were obtained from six areas of the UGI tract (the esophagus, gastric body, antrum and angulus, duodenal bulb, and descending duodenum). Both demographic and clinical data were collected. Results: Among the 169 included patients, endoscopic and histological lesions suspected to be of UGI CD were found in 74 (43.79%) and 106 (62.72%) patients respectively. 7 (4.14%) patients had non-caseating granulomas, 15 (8.88%) patients had focally enhanced gastritis, and 36 (21.3%) patients had focal active gastritis. 137 (81.1%) patients had no UGI symptoms, among these, endoscopic and/or pathological abnormalities were observed in 108 (78.8%) patients. Twenty-four (75%) patients with UGI symptoms did not have any endoscopic or histological abnormalities. In total, the rates of non-caseating granulomas, focally enhanced gastritis, and focal active inflammation were significantly higher in the asymptomatic group (P=0.033). According to the endoscopic and histological features, 26 patients (15.4%) were identified having UGI CD involvement among 169 CD patients, and among these, 24 patients (17.5%) were asymptomatic, whereas 2 (6.3%) were symptomatic. We further observed that the frequency of characteristic histological lesions was significantly higher in the gastric antrum and angulus than in any other biopsy site (P= 0.028). Focally enhanced gastritis and focal active inflammation had significantly higher frequencies than non-caseating granulomas in the stomach (P<0.01). There were no significant differences in the basic data between patients with or without endoscopic or pathological abnormalities (P>0.05). Conclusion: There was a high frequency of UGI involvement in adult CD patients, irrespective of the presence or absence of UGI symptoms. Confirmable characteristic UGI lesions of CD are also common, and routine gastroscopy and biopsy may be recommended for patients suspected of having or diagnosed with CD. Focally enhanced gastritis and focal active inflammation were observed to be more common than non-caseating granulomas which may helpful in the diagnosis of CD and are worth focusing on.
S-429
AGA Abstracts