~HE~CHR~M~~YT~MY-.~~ URCENT SUHGICAL CONDITION. J. Ringel, K. Hurt and Rozhl.
J. lsede. SvBb, 385. 1%*5.
J..
A short
is given
report
chir.
44:382,
of a pheochro-
mocytoma of the right adrenal in a 11 year old boy, where the most interesting feature was the need for immediate removal of the tumor on account of retinal edema and hemorrhages with loss of eyesight. Within 6 months of operation the ophthalmologic findings showed only irrelevant changes in the fundus.-V. Kafka. OF NEOPLASM IN Rxr THYROID GLAND BY X-&RADIATION OF A SINGLE
INDUCTION
LOBE. C. W. Nichols, Jr., S. Lindsay, G. E. Sheline and I. L. Chsikof. Arch. Path. HO:177.
1965
A total of 1,191 female Long-Evans rats from 6 to 7 weeks of age were divided into control and treatment groups. A stock diet and a desiccated thyroid containing
213
SURGERY
diet
were
used.
One
thousand
r. was
ap-
plied to the left or right lobe of the thyroid to each group of rats on the different diets. The survivors were sacrificed at the age of 2 years. Benign adenomas, mainly follicular, were found in the thyroid glands of 15 per cent of the irradiated rats, and in 3 per cent of the normal control rats. On those rats fed a desiccated thyroid containing diet, no adenomas were found indicating complete suppression of the development of these lesions by desiccated thyroid. Three papillary carcinomas were found in thyroid glands of the irradiated rats. Two of these carcinomas developed in lobes that had been shielded from irradiation. There was no indication that natmally occurring thyroid lobular carcinomas were influenced either by x-irradiation or the feeding of desiccated thyroid. Thyroid stimulating hormone or irradiation per se are both implicated as the agent in development of malignant papillary neoplasms in this series.-Daniel T. Cloud.