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PO21-650 EPICARDIAL ADIPOSE TISSUE IS AN INDEPENDENT RISK FACTOR FOR CORONARY ARTERY DISEASE
Poster Sessions PO21 Obesity/Metabolic syndrome boys) ageing from 6 to 16 years old. Secondary, this value was correlated with height, weight, BMI, systolic blood pressure, age and sex. Results: Waist circumference was considerably higher in boys’ population comparing to girls’ population (boys: 66.9 girls: 61.7 p<0.024 95% CI 2.92-7.51) and was increasing by age, in both genders. The correlation between Body Weight, BMI and Waist Circumference was 0.01, while waist circumference correlation with height and systolic blood pressure was considerably lower. Conclusions: Waist circumference should be considered as a useful tool for obesity evaluation in childhood, although additional studies are required for better comprehension and more effective use of paediatric obesity indexes. PO21-648
CHILDWOOD OBESITY. A 16 YEARS FOLLOW-UP STUDY IN GREEK CHILDREN
H. Bilianou 1 , C. Ntellos 1 , G. Fountakis 2 , V. Tsiribis 1 , F. Kritikou 1 , E. Halli 1 , S. Foussas 1 . 1 Tzanio Hospital, Pireas, Greece; 2 GP Iraklion, Crete, Greece
PO21-649
CARDIOVASCULAR RISK FACTORS PREVALENCE IN THE SPANISH POPULATION AND IMPACT OF OBESITY (DORICA STUDY)
J. Millan 1 , T. Mantilla 2 , J. Aranceta 4 , B. Moreno 1 , M. Foz 5 , S. Monereo 3 . Gregorio Marañon Hospital, Madrid, Spain; 2 IMSALUD Health Clinic Prosperidad, Madrid, Spain; 3 Getafe Hospital, Madrid, Spain; 4 Nutrition Community Town Hall, Bilbao, Spain; 5 Clinic Hospital, Barcelona, Spain 1 IMSALUD
Objective: To know the prevalence of obesity and Cardiovascular Risk Factors (CVRF) in the Spanish population. Persons and Methods: 14.616 healthy subjects (6.796 men, 7.820 women) ages 25-64 years old. HT defined PA ≥ 140/90 mmHg; Hypercholesterolemia: CT ≥ 240 mg/dl; Hypertrigliceridemia: TG ≥ 150 mg/dl; Diabetes Mellitus: ≥ 126 mg/dl; Obesity BMI > 30 kg/m2 ; tobacco consumption. Statistical analysis: SPSS 10 and Stata 7. Statistical significance p <0, 05. Results: 13.2% of men and 17.5% of women were obese. HT 36.4% men and 24.8% women. CT≥240 mg/dl: 20.7% men and 18.2% women. HDL <40 mg/dl: 15% men and 6% women. Smoked: 48% men and 30.2% women. Type 2 DM: 5.3% men and 2.4% women. BMI> 30: 13.2% men and 17.5% women. Obesity was increasing with age and significantly in women from 45 years. 26% of the obese people had 2 associate CVRF. No physical activity: 62.6%. Metabolic syndrome 10.87% (12% men, 9.9% women). Lipids increase significantly with BMI, high in the hypertense subjects. Positive correlations between BMI and BP and BMI and LDLc. Conclusions: There is a high association between obesity and CVRF. The higher BMI the more increased in BP and lipids. Prevalence of metabolic syndrome is high. It is necessary to promote measures in order to improve the control of obesity with preventive programs, food habits and physical exercise.
EPICARDIAL ADIPOSE TISSUE IS AN INDEPENDENT RISK FACTOR FOR CORONARY ARTERY DISEASE
S. Eroglu, L.E. Sade, A.S. Ozgul, H. Bozbas, A. Yildirir, U. Bal, H. Muderrisoglu. Department of Cardiology, University of Baskent, Ankara, Turkey Background and Aim: It has been shown that the epicardial adipose tissue is associated with metabolic syndrome. We aimed to test the hypothesis that epicardial adipose tissue is a risk factor for coronary artery disease (CAD). Method: Twenty eight patients (13 male, 15 female; 60±9 years) who underwent coronary angiography were studied. Carotid intima media thickness (IMT) was evaluated by carotid ultrasonography and epicardial adipose tissue by 2-D echocardiography. Serum C- reactive protein (CRP) levels were also measured. Results were correlated with coronary angiographic findings. Results: Group mean epicardial adipose tissue thickness, carotid IMT, and CRP levels were, 5.9±1.8 mm, 0.86±0.19 mm, and 6.7±6.3 mg/L respectively. Angiography revealed significant CAD in 10 patients. Epicardial adipose tissue thickness correlated significantly with carotid IMT (r= 0.47 p= 0.012), and CRP levels (r=0.47; p=0.02). Epicardial adipose tissue, carotid IMT and serum CRP levels were higher in patients with CAD as compared to those with normal coronary arteries (p<0.001, p<0.05, p<0.05 respectively). Epicardial adipose tissue was found to be the only independent predictor of CAD on multivariate regression model including CRP, IMT and epicardial adipose tissue (p=0.002, [95%CI, 0.7-2.8]). Conclusion: These findings suggest that echocardiographically measured epicardial adipose tissue is an independent risk factor for CAD and may be useful for risk stratification. PO21-651
MARKERS OF OBESITY AND ACUTE MYOCARDIAL INFARCTION
V. Raos, I. Rajcan-Spoljaric, H. Vrazic, M. Raguz, J. Sikic-Vagic, B. Starcevic, M. Spoljaric, J. Vincelj, T. Katic, M. Bergovec. Department of Cardiology, University Hospital Dubrava, Zagreb, Croatia Background: The role of obesity as independent risk factor for cardiovascular disease (CVD) is well known. Waist circumference (WC), waist-to-hip ratio (WHR) and body mass index (BMI) are widely used indicators of abdominal obesity. Aims: The aims of this study were to determine markers of obesity and to investigate relation between them and coronary risk factors in patients with acute myocardial infarction (AMI). Methods: The study included 148 patients, 104 men and 44 women, aged on average 62,28 (59,46 men and 68,93 women) years, hospitalized in CCU between April and October 2006. Subjects were classified into 2 groups: 1. AMI with ST elevation (STEMI) and 2. AMI without ST elevation (NSTEMI). BMI, WC, WHR, arterial hypertension (AH), smoking, cholesterol, triglycerides, LDL-C and HDL-C were measured. Results: STEMI and NSTEMI group comparison showed higher triglycerides level in STEMI patients (P=0.004) and higher prevalence of AH (P=0.02). STEMI group differed from all patients concerning age (younger, P=0.01), weight (more weight, P=0.001), LDL-C (lower level, P=0.003) and AH (higher prevalence, P=0.04). NSTEMI group differed from all patients concerning weight (lesser weight, P=0.04), waist (larger waist, P=0.04), cholesterol (higher level, P=0.04) and LDL-C (higher level, P=0.001). Conclusions: Data suggest that relations of markers of obesity as risk factors for CVD are opposite to previous studies. Important risk factors for STEMI were larger weight and younger age and for NSTEMI larger waist, higher cholesterol and LDL-c. Most significant finding using bivariate correlation analysis was positive correlation between WHR and cholesterol (R=0.31) in STEMI group. PO21-652
THE BODY MASS INDEX AS PREDICTOR OF POOR OUTCOMES IN CHRONIC HEART FAILURE PATIENTS AND PRESERVED LEFT VENTRICULAR SYSTOLIC FUNCTION
O.V. Kuryata, O.S. Mitrohina. Dept. of Hospital Therapy #1, Dnepropetrovsk State Medical Academy, Dnepropetrovsk, Ukraine We aimed to evaluate the body mass index (BMI), haemodynamics and endothelial vascular function and its relationship in patients with heart failure and preserved left ventricular systolic function.
76th Congress of the European Atherosclerosis Society, June 10–13, 2007, Helsinki, Finland
POSTER SESSIONS
Background and Aims: Obesity in children has becoming an increasing morbidity worldwide. The disease is related to metabolic abnormalities (increased levels of triglycerides and blood glucose and decreased HDL), sleep apnea, orthopedic and respiratory alterations, psychosocial problems and precoce puberty. In our study, we intended to evaluate the eventually changes in the anthropometric parameters of children during a 16 years follow-up. Methods: From 01.01.1990 to 31.12.2005, 11394 children 6575 boys and 4819 girls 4-16 years old, from the general population, were evaluated for athletic participation. Weight, height, Body Mass Index, blood pressure, electrocardiogram and echocardiogram were preformed at that purpose. All children with congenital heart diseases, endocrinopathies including diabetes, and foreigners were excluded from the study. Results: Boys had a significantly higher weight compared to girls (39,01 kg vs 37.35 kg, p<.002). Children at the city of Pireas gained about 2 kg (37.2 vs 39.3) in the years from 1990 to 2005 (sig .022 95% CI – 3.93-.30). Another parameter fount to be increased in systolic blood pressure (99.2 vs 101.2 sig .001 95% CI – 3.19-.85) Conclusions: Childhood obesity presents an alarming increase and probably contributes to an increase of the obesity in adults for the next decades. This serious problem has to be resolved urgently for the prevention of atherosclerosis and its complications.
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175
CHILDWOOD OBESITY. A 16 YEARS FOLLOW-UP STUDY IN GREEK CHILDREN
H. Bilianou 1 , C. Ntellos 1 , G. Fountakis 2 , V. Tsiribis 1 , F. Kritikou 1 , E. Halli 1 , S. Foussas 1 . 1 Tzanio Hospital, Pireas, Greece; 2 GP Iraklion, Crete, Greece
PO21-649
CARDIOVASCULAR RISK FACTORS PREVALENCE IN THE SPANISH POPULATION AND IMPACT OF OBESITY (DORICA STUDY)
J. Millan 1 , T. Mantilla 2 , J. Aranceta 4 , B. Moreno 1 , M. Foz 5 , S. Monereo 3 . Gregorio Marañon Hospital, Madrid, Spain; 2 IMSALUD Health Clinic Prosperidad, Madrid, Spain; 3 Getafe Hospital, Madrid, Spain; 4 Nutrition Community Town Hall, Bilbao, Spain; 5 Clinic Hospital, Barcelona, Spain 1 IMSALUD
Objective: To know the prevalence of obesity and Cardiovascular Risk Factors (CVRF) in the Spanish population. Persons and Methods: 14.616 healthy subjects (6.796 men, 7.820 women) ages 25-64 years old. HT defined PA ≥ 140/90 mmHg; Hypercholesterolemia: CT ≥ 240 mg/dl; Hypertrigliceridemia: TG ≥ 150 mg/dl; Diabetes Mellitus: ≥ 126 mg/dl; Obesity BMI > 30 kg/m2 ; tobacco consumption. Statistical analysis: SPSS 10 and Stata 7. Statistical significance p <0, 05. Results: 13.2% of men and 17.5% of women were obese. HT 36.4% men and 24.8% women. CT≥240 mg/dl: 20.7% men and 18.2% women. HDL <40 mg/dl: 15% men and 6% women. Smoked: 48% men and 30.2% women. Type 2 DM: 5.3% men and 2.4% women. BMI> 30: 13.2% men and 17.5% women. Obesity was increasing with age and significantly in women from 45 years. 26% of the obese people had 2 associate CVRF. No physical activity: 62.6%. Metabolic syndrome 10.87% (12% men, 9.9% women). Lipids increase significantly with BMI, high in the hypertense subjects. Positive correlations between BMI and BP and BMI and LDLc. Conclusions: There is a high association between obesity and CVRF. The higher BMI the more increased in BP and lipids. Prevalence of metabolic syndrome is high. It is necessary to promote measures in order to improve the control of obesity with preventive programs, food habits and physical exercise.
EPICARDIAL ADIPOSE TISSUE IS AN INDEPENDENT RISK FACTOR FOR CORONARY ARTERY DISEASE
S. Eroglu, L.E. Sade, A.S. Ozgul, H. Bozbas, A. Yildirir, U. Bal, H. Muderrisoglu. Department of Cardiology, University of Baskent, Ankara, Turkey Background and Aim: It has been shown that the epicardial adipose tissue is associated with metabolic syndrome. We aimed to test the hypothesis that epicardial adipose tissue is a risk factor for coronary artery disease (CAD). Method: Twenty eight patients (13 male, 15 female; 60±9 years) who underwent coronary angiography were studied. Carotid intima media thickness (IMT) was evaluated by carotid ultrasonography and epicardial adipose tissue by 2-D echocardiography. Serum C- reactive protein (CRP) levels were also measured. Results were correlated with coronary angiographic findings. Results: Group mean epicardial adipose tissue thickness, carotid IMT, and CRP levels were, 5.9±1.8 mm, 0.86±0.19 mm, and 6.7±6.3 mg/L respectively. Angiography revealed significant CAD in 10 patients. Epicardial adipose tissue thickness correlated significantly with carotid IMT (r= 0.47 p= 0.012), and CRP levels (r=0.47; p=0.02). Epicardial adipose tissue, carotid IMT and serum CRP levels were higher in patients with CAD as compared to those with normal coronary arteries (p<0.001, p<0.05, p<0.05 respectively). Epicardial adipose tissue was found to be the only independent predictor of CAD on multivariate regression model including CRP, IMT and epicardial adipose tissue (p=0.002, [95%CI, 0.7-2.8]). Conclusion: These findings suggest that echocardiographically measured epicardial adipose tissue is an independent risk factor for CAD and may be useful for risk stratification. PO21-651
MARKERS OF OBESITY AND ACUTE MYOCARDIAL INFARCTION
V. Raos, I. Rajcan-Spoljaric, H. Vrazic, M. Raguz, J. Sikic-Vagic, B. Starcevic, M. Spoljaric, J. Vincelj, T. Katic, M. Bergovec. Department of Cardiology, University Hospital Dubrava, Zagreb, Croatia Background: The role of obesity as independent risk factor for cardiovascular disease (CVD) is well known. Waist circumference (WC), waist-to-hip ratio (WHR) and body mass index (BMI) are widely used indicators of abdominal obesity. Aims: The aims of this study were to determine markers of obesity and to investigate relation between them and coronary risk factors in patients with acute myocardial infarction (AMI). Methods: The study included 148 patients, 104 men and 44 women, aged on average 62,28 (59,46 men and 68,93 women) years, hospitalized in CCU between April and October 2006. Subjects were classified into 2 groups: 1. AMI with ST elevation (STEMI) and 2. AMI without ST elevation (NSTEMI). BMI, WC, WHR, arterial hypertension (AH), smoking, cholesterol, triglycerides, LDL-C and HDL-C were measured. Results: STEMI and NSTEMI group comparison showed higher triglycerides level in STEMI patients (P=0.004) and higher prevalence of AH (P=0.02). STEMI group differed from all patients concerning age (younger, P=0.01), weight (more weight, P=0.001), LDL-C (lower level, P=0.003) and AH (higher prevalence, P=0.04). NSTEMI group differed from all patients concerning weight (lesser weight, P=0.04), waist (larger waist, P=0.04), cholesterol (higher level, P=0.04) and LDL-C (higher level, P=0.001). Conclusions: Data suggest that relations of markers of obesity as risk factors for CVD are opposite to previous studies. Important risk factors for STEMI were larger weight and younger age and for NSTEMI larger waist, higher cholesterol and LDL-c. Most significant finding using bivariate correlation analysis was positive correlation between WHR and cholesterol (R=0.31) in STEMI group. PO21-652
THE BODY MASS INDEX AS PREDICTOR OF POOR OUTCOMES IN CHRONIC HEART FAILURE PATIENTS AND PRESERVED LEFT VENTRICULAR SYSTOLIC FUNCTION
O.V. Kuryata, O.S. Mitrohina. Dept. of Hospital Therapy #1, Dnepropetrovsk State Medical Academy, Dnepropetrovsk, Ukraine We aimed to evaluate the body mass index (BMI), haemodynamics and endothelial vascular function and its relationship in patients with heart failure and preserved left ventricular systolic function.
76th Congress of the European Atherosclerosis Society, June 10–13, 2007, Helsinki, Finland
POSTER SESSIONS
Background and Aims: Obesity in children has becoming an increasing morbidity worldwide. The disease is related to metabolic abnormalities (increased levels of triglycerides and blood glucose and decreased HDL), sleep apnea, orthopedic and respiratory alterations, psychosocial problems and precoce puberty. In our study, we intended to evaluate the eventually changes in the anthropometric parameters of children during a 16 years follow-up. Methods: From 01.01.1990 to 31.12.2005, 11394 children 6575 boys and 4819 girls 4-16 years old, from the general population, were evaluated for athletic participation. Weight, height, Body Mass Index, blood pressure, electrocardiogram and echocardiogram were preformed at that purpose. All children with congenital heart diseases, endocrinopathies including diabetes, and foreigners were excluded from the study. Results: Boys had a significantly higher weight compared to girls (39,01 kg vs 37.35 kg, p<.002). Children at the city of Pireas gained about 2 kg (37.2 vs 39.3) in the years from 1990 to 2005 (sig .022 95% CI – 3.93-.30). Another parameter fount to be increased in systolic blood pressure (99.2 vs 101.2 sig .001 95% CI – 3.19-.85) Conclusions: Childhood obesity presents an alarming increase and probably contributes to an increase of the obesity in adults for the next decades. This serious problem has to be resolved urgently for the prevention of atherosclerosis and its complications.
PO21-650
175