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PP - ROLE OF MSX1, TCOF1, FGFR1, COL2A1, WNT3, AND TIMP3 POLYMORPHISMS IN NONSYNDROMIC ORAL CLEFTS
OOOO Volume 123, Number 2 environmental factors may be associated with the risk of NSCL/P. This multicenter study evaluated the interactions of 12 single nucleotide polymorphisms in DNA repair genes (ADPRT, OGG1, MLH1, APEX1, XRCC3, RAD51, XRCC1 and ERCC2) with common maternal exposures, including agrotoxics, cigarette smoking, and consumption of alcohol and drugs during the first trimester of gestation, with the risk of NSCL/P in 223 trios composed of two living biological parents and one affected. The results showed a significant interaction between RAD51 rs1801321 polymorphism and maternal cigarette smoking. Children carrying the minor T allele of rs1801321 and exposed to maternal cigarette smoking showed an increased risk in comparison with children with the T allele of non-exposed mothers (OR¼4.25, p¼0.004). Although other gene-environment interactions were detected in this cohort, none has resisted the Bonferroni correction for multiple tests. In conclusion, the results of this study suggested that RAD51 rs1801321 genotypes interact with maternal cigarette smoking to increase the risk of NSCL/P.
PP - ROLE OF MSX1, TCOF1, FGFR1, COL2A1, WNT3, AND TIMP3 POLYMORPHISMS IN NONSYNDROMIC ORAL CLEFTS. RENATO ASSIS MACHADO, SIBELE NASCIMENTO DE AQUINO, HERCÍLIO MARTELLI, JÚNIOR, SILVIA REGINA DE ALMEIDA REIS, HELENARA SALVATI BERTOLOSSI MOREIRA, DARLENE CAMATI PERSUHN, RICARDO D. COLETTA. FOP/UNICAMP. Craniofacial development involves a series of highly coordinated events, and polymorphisms in genes that control these events can affect the morphogenesis of the lip and palate, resulting in nonsyndromic oral clefts. This multicenter study evaluated the association of polymorphisms in genes related to craniofacial development, including TNP1, MSX1, TCOF1, FGFR1, COL2A1, WNT3, and TIMP3. A sample with 296 trios was initially evaluated by transmission disequilibrium test, and significant associations were validated in a case-control analysis based on the individual ancestry proportions in 507 patients affected with oral clefts and 599 controls. A significant overtransmission of rs28372960 and rs7829058 polymorphisms in nonsyndromic cleft lip with or without cleft palate (NSCLP) trios was observed (p¼0.04), as well as the rs11653738 polymorphism in nonsyndromic cleft palate (NSCP) trios (p¼0.04). However, the structured case-control analysis did not confirm those associations. The haplotype T-C-C formed by rs28372960, rs15251, and rs2569062 polymorphisms in the TCOF1 gene was significantly more frequent in patients with NSCLP than in the control group (p¼0.01). With the modest associations, our results do not support the hypothesis that TNP1, MSX1, TCOF1, FGFR1, COL2A1, WNT3, and TIMP3 variants are risk factors for oral clefts in the Brazilian population.
PP - FIBROMATOSIS IN POSTERIOR UPPER JAW BILATERALLY: A CASE REPORT. LEO KRAETHER NETO, JAMIL SALEH, MICHELE GASSEN KELLERMANN, JOEL HENRIQUE ELLWANGER, DANIELI ROSANE DALLEMOLE. UNIVERSIDADE DE SANTA CRUZ DO SUL - UNISC/ UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL UFRGS.
Gingival fibromatosis is a form of increased gingival volume that consists of firm and fibrous tissue. Its evolution is slow and
ABSTRACTS Abstracts e45 progressive. We report one case involving a 44-year-old male patient with leukoderma who was an alcoholic and former smoker. The patient presented to the Ambulatory of Oral Diagnosis at the University of Santa Cruz do Sul (UNISC) complaining of increased bilateral volume in the maxillary tuberosity as well as painless and episodic bleeding. The intraoral examination revealed the presence of gingival tissue superimposed on the upper posterior molars that extended past the tuberosity. The growth was asymptomatic and did not show changes. Panoramic radiographies showed no bone loss or changes consistent with a gingival overgrowth. An excisional biopsy was performed using a cold scalpel and electrocautery. Wound healing by secondary intention was implemented by the use of prosthetic device protecting. The histopathological findings indicated the presence of epithelial hyperplasia and fibrosis connective tissue, which are consistent with fibromatosis. The patients postoperative clinical condition remains under control.
PP - ORTHOKERATINIZED ODONTOGENIC CYST: A CASE REPORT. LEO KRAETHER NETO, MICHELE GASSEN KELLERMANN, JOEL HENRIQUE ELLWANGER, DANIELI ROSANE DALLEMOLE. UNIVERSIDADE DE SANTA CRUZ DO SUL - UNISC/UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - UFRGS. Orthokeratinized odontogenic cyst (OOC) is a relatively uncommon developmental cyst comprising approximately 10% of developmental cyst cases and has been previously coded as an odontogenic keratocyst. This is a case report of a 10-year-old male child with leukoderma. The patient attended a medical consultation complaining of trauma during a football game. The trauma was along the jaw on the right side and happened due to a hit with another player’s shoulder. Since then, the child presented with trismus. The patient was evaluated by computed tomography in the medical emergency service and, unexpectedly, an osteolytic lesion with well-defined limits was observed throughout the body of the jaw. We chose the total removal of the tumor, taking into account the benign characteristics of the lesion. The lesion was completely removed under general anesthesia via intraoral access. There was no pathological fracture, although the lesion was extensive. The alveolar neurovascular bundle was preserved. The histological findings indicated OOC. The patient is well, with no postoperative complication. He will have a panoramic control x-ray within six months.
PP - MULTIPLE ENDOCRINE NEOPLASIA TYPE 2B IN CHILD: CASE REPORT. ROSANA BARROS, CAMILA FREITAS, PAULA LOPES, SILVIA SANCHES, LUIZ SOUZA, OLIVIA VIANNA. UNIVERSIDADE FEDERAL DE MATO GROSSO DO SUL. Multiple endocrine neoplasias are autosomal dominant genetic syndromes. The MEN type 2B is featured by mucosal neuromas with tumoral involvement in thyroid, parathyroid and adrenal. Individuals present marfanoid and dolichocephalic body, narrow face, thick and protruding lips, overbite, anterior diastema, and may have nodular lesions on the tongue and oral mucosa. The patient, S.A.S., female, African American, 5 years, accompanied by her father, appeared in 1FAODO-UFMS suspected of retention cyst or pyogenic granuloma. On examination, there were thin and elongated limbs, café au lait spots on trunk, front and hypertelorism bossa, primary teeth, permanent teeth
PP - ROLE OF MSX1, TCOF1, FGFR1, COL2A1, WNT3, AND TIMP3 POLYMORPHISMS IN NONSYNDROMIC ORAL CLEFTS. RENATO ASSIS MACHADO, SIBELE NASCIMENTO DE AQUINO, HERCÍLIO MARTELLI, JÚNIOR, SILVIA REGINA DE ALMEIDA REIS, HELENARA SALVATI BERTOLOSSI MOREIRA, DARLENE CAMATI PERSUHN, RICARDO D. COLETTA. FOP/UNICAMP. Craniofacial development involves a series of highly coordinated events, and polymorphisms in genes that control these events can affect the morphogenesis of the lip and palate, resulting in nonsyndromic oral clefts. This multicenter study evaluated the association of polymorphisms in genes related to craniofacial development, including TNP1, MSX1, TCOF1, FGFR1, COL2A1, WNT3, and TIMP3. A sample with 296 trios was initially evaluated by transmission disequilibrium test, and significant associations were validated in a case-control analysis based on the individual ancestry proportions in 507 patients affected with oral clefts and 599 controls. A significant overtransmission of rs28372960 and rs7829058 polymorphisms in nonsyndromic cleft lip with or without cleft palate (NSCLP) trios was observed (p¼0.04), as well as the rs11653738 polymorphism in nonsyndromic cleft palate (NSCP) trios (p¼0.04). However, the structured case-control analysis did not confirm those associations. The haplotype T-C-C formed by rs28372960, rs15251, and rs2569062 polymorphisms in the TCOF1 gene was significantly more frequent in patients with NSCLP than in the control group (p¼0.01). With the modest associations, our results do not support the hypothesis that TNP1, MSX1, TCOF1, FGFR1, COL2A1, WNT3, and TIMP3 variants are risk factors for oral clefts in the Brazilian population.
PP - FIBROMATOSIS IN POSTERIOR UPPER JAW BILATERALLY: A CASE REPORT. LEO KRAETHER NETO, JAMIL SALEH, MICHELE GASSEN KELLERMANN, JOEL HENRIQUE ELLWANGER, DANIELI ROSANE DALLEMOLE. UNIVERSIDADE DE SANTA CRUZ DO SUL - UNISC/ UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL UFRGS.
Gingival fibromatosis is a form of increased gingival volume that consists of firm and fibrous tissue. Its evolution is slow and
ABSTRACTS Abstracts e45 progressive. We report one case involving a 44-year-old male patient with leukoderma who was an alcoholic and former smoker. The patient presented to the Ambulatory of Oral Diagnosis at the University of Santa Cruz do Sul (UNISC) complaining of increased bilateral volume in the maxillary tuberosity as well as painless and episodic bleeding. The intraoral examination revealed the presence of gingival tissue superimposed on the upper posterior molars that extended past the tuberosity. The growth was asymptomatic and did not show changes. Panoramic radiographies showed no bone loss or changes consistent with a gingival overgrowth. An excisional biopsy was performed using a cold scalpel and electrocautery. Wound healing by secondary intention was implemented by the use of prosthetic device protecting. The histopathological findings indicated the presence of epithelial hyperplasia and fibrosis connective tissue, which are consistent with fibromatosis. The patients postoperative clinical condition remains under control.
PP - ORTHOKERATINIZED ODONTOGENIC CYST: A CASE REPORT. LEO KRAETHER NETO, MICHELE GASSEN KELLERMANN, JOEL HENRIQUE ELLWANGER, DANIELI ROSANE DALLEMOLE. UNIVERSIDADE DE SANTA CRUZ DO SUL - UNISC/UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - UFRGS. Orthokeratinized odontogenic cyst (OOC) is a relatively uncommon developmental cyst comprising approximately 10% of developmental cyst cases and has been previously coded as an odontogenic keratocyst. This is a case report of a 10-year-old male child with leukoderma. The patient attended a medical consultation complaining of trauma during a football game. The trauma was along the jaw on the right side and happened due to a hit with another player’s shoulder. Since then, the child presented with trismus. The patient was evaluated by computed tomography in the medical emergency service and, unexpectedly, an osteolytic lesion with well-defined limits was observed throughout the body of the jaw. We chose the total removal of the tumor, taking into account the benign characteristics of the lesion. The lesion was completely removed under general anesthesia via intraoral access. There was no pathological fracture, although the lesion was extensive. The alveolar neurovascular bundle was preserved. The histological findings indicated OOC. The patient is well, with no postoperative complication. He will have a panoramic control x-ray within six months.
PP - MULTIPLE ENDOCRINE NEOPLASIA TYPE 2B IN CHILD: CASE REPORT. ROSANA BARROS, CAMILA FREITAS, PAULA LOPES, SILVIA SANCHES, LUIZ SOUZA, OLIVIA VIANNA. UNIVERSIDADE FEDERAL DE MATO GROSSO DO SUL. Multiple endocrine neoplasias are autosomal dominant genetic syndromes. The MEN type 2B is featured by mucosal neuromas with tumoral involvement in thyroid, parathyroid and adrenal. Individuals present marfanoid and dolichocephalic body, narrow face, thick and protruding lips, overbite, anterior diastema, and may have nodular lesions on the tongue and oral mucosa. The patient, S.A.S., female, African American, 5 years, accompanied by her father, appeared in 1FAODO-UFMS suspected of retention cyst or pyogenic granuloma. On examination, there were thin and elongated limbs, café au lait spots on trunk, front and hypertelorism bossa, primary teeth, permanent teeth