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Pregnancy and polycystic disease of the kidneys
1633
SELECTED ABSTRACTS
Volume 68 Number 6
21 patients, 10 were followed, and of these 3 became pregnant. One individual gave birth to 3 full-term living children. The total percentage of success was 14.3 per cent and in those which were followed, 30 per cent. A rather complete citation of literature on this subject is given. STEWART A. FISH, M.D.
de Vere, :R. D., and Dempster, K. :R.: A Case of the Stein-Leventhal Syndrome Associated With Carcinoma of the Endometrium, p. 865. The authors report a case which met the clinical requirement for the Stein-Leventhal syndrome. Wedge resection of the ovaries was performed and at this time the endometrial curettings revealed cystic hyperplasia. Six months later curettage showed carcinoma of the endometrium and total hysterectomy with bilateral salpingo-oophorectomy was performed. The authors note references by other investigators who stress the possibility of endometrial carcinoma arising in patients with the Stein-Leventhal syndrome. No conclusions are drawn, but the reader is left with the impression that prolonged estrogen stimulation of the endometrium from persistent unruptured follicles in this syndrome may increase the chance of occurrence of carcinoma of the endometrium. STEW ART
Millar,
w.
Gordon:
A, FISH; M.D.
Pregnancy and Polycystic Disease of the Kidneys, p. 868.
Because of the paucity of reports of polycystic disease of the kidney associated with pregnancy, 5 cases which occurred at the Royal Maternity Hospital, Glasgow, are reported. Previous reports of the same condition are cited and clinical signs and symptoms are described. Of the 5 patients reported upon, 3 developed recurrent urinary tract infections which were controlled in all instances with antibiotics. HyperteRsion was severe in 3 cases and led to renal failure and death in one instance. V! tne other ;, nypertensive patients one developed eclampsia and one accidental hemorrhage. The author discusses the significance of hypertension in relation to polycystic disease and lists other urinary tract abnormalities which may be etiological agents in the development of hypertension. Despite the small series the author justifiably concludes that: (1) Asymptomatic polycystic disease of the kidney is not an indication for termination of pregnancy. (2) Despite frequent bouts of urinary tract infection, pregnancy should be allowed to continue, since antibiotics are usually successful in the control of these infections. ( 3) When hypertension is present, pregnancy is hazardous and interruption is advised. STEWART A. FISH, M.D.
Watson, H. B., and Taylor, C. W.: Vulva, p. 917.
A Case of Granular Cell Myoblastoma of the
The authors report a single case of granular-cell myoblastoma of the vulva which occurred in a 32-year-old white woman. Myoblastoma is the name given to a tumor which occurs in striated muscle, usually the tongue. It may also be seen below mucous membrane and skin. Histologically, the cells resemble myoblasts, are large and elongated, and show markedly granular acidophilic cytoplasm. The actual origin from myoblasts is open to doubt, and though striations and mergene into muscle fibers have been demonstrated in lesions of the tongue and skeletal muscles, these features are not seen in the cutaneous nodules. Willis believes the tumor is rarely neoplastic and that it may result from trauma. Other authors believe the tumor may arise from pluripotent mesenchymal cells. 1'he term myoblastoma is somewhat misleading since it implies malignancy. 1.nere are only a 1.ew eases reported which showed recurrence or metastasis. An abnormal proliferation of squamous epithelium overlying the tumors occurs and resembles early squamous-cell carcinoma. There is no evidence that this pseudomalignant proliferation is of any significance and its origin appears to be a reactive proliferation from the underlying growth.
SELECTED ABSTRACTS
Volume 68 Number 6
21 patients, 10 were followed, and of these 3 became pregnant. One individual gave birth to 3 full-term living children. The total percentage of success was 14.3 per cent and in those which were followed, 30 per cent. A rather complete citation of literature on this subject is given. STEWART A. FISH, M.D.
de Vere, :R. D., and Dempster, K. :R.: A Case of the Stein-Leventhal Syndrome Associated With Carcinoma of the Endometrium, p. 865. The authors report a case which met the clinical requirement for the Stein-Leventhal syndrome. Wedge resection of the ovaries was performed and at this time the endometrial curettings revealed cystic hyperplasia. Six months later curettage showed carcinoma of the endometrium and total hysterectomy with bilateral salpingo-oophorectomy was performed. The authors note references by other investigators who stress the possibility of endometrial carcinoma arising in patients with the Stein-Leventhal syndrome. No conclusions are drawn, but the reader is left with the impression that prolonged estrogen stimulation of the endometrium from persistent unruptured follicles in this syndrome may increase the chance of occurrence of carcinoma of the endometrium. STEW ART
Millar,
w.
Gordon:
A, FISH; M.D.
Pregnancy and Polycystic Disease of the Kidneys, p. 868.
Because of the paucity of reports of polycystic disease of the kidney associated with pregnancy, 5 cases which occurred at the Royal Maternity Hospital, Glasgow, are reported. Previous reports of the same condition are cited and clinical signs and symptoms are described. Of the 5 patients reported upon, 3 developed recurrent urinary tract infections which were controlled in all instances with antibiotics. HyperteRsion was severe in 3 cases and led to renal failure and death in one instance. V! tne other ;, nypertensive patients one developed eclampsia and one accidental hemorrhage. The author discusses the significance of hypertension in relation to polycystic disease and lists other urinary tract abnormalities which may be etiological agents in the development of hypertension. Despite the small series the author justifiably concludes that: (1) Asymptomatic polycystic disease of the kidney is not an indication for termination of pregnancy. (2) Despite frequent bouts of urinary tract infection, pregnancy should be allowed to continue, since antibiotics are usually successful in the control of these infections. ( 3) When hypertension is present, pregnancy is hazardous and interruption is advised. STEWART A. FISH, M.D.
Watson, H. B., and Taylor, C. W.: Vulva, p. 917.
A Case of Granular Cell Myoblastoma of the
The authors report a single case of granular-cell myoblastoma of the vulva which occurred in a 32-year-old white woman. Myoblastoma is the name given to a tumor which occurs in striated muscle, usually the tongue. It may also be seen below mucous membrane and skin. Histologically, the cells resemble myoblasts, are large and elongated, and show markedly granular acidophilic cytoplasm. The actual origin from myoblasts is open to doubt, and though striations and mergene into muscle fibers have been demonstrated in lesions of the tongue and skeletal muscles, these features are not seen in the cutaneous nodules. Willis believes the tumor is rarely neoplastic and that it may result from trauma. Other authors believe the tumor may arise from pluripotent mesenchymal cells. 1'he term myoblastoma is somewhat misleading since it implies malignancy. 1.nere are only a 1.ew eases reported which showed recurrence or metastasis. An abnormal proliferation of squamous epithelium overlying the tumors occurs and resembles early squamous-cell carcinoma. There is no evidence that this pseudomalignant proliferation is of any significance and its origin appears to be a reactive proliferation from the underlying growth.