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Program and abstracts of the Fourth Meeting of Japanese Section of the International Society for Heart Research
PROGRAM AND ABSTRACTS THE FOURTH MEETING THE INTERNATIONAL
4-5
OF JAPANESE
SOCIETY
November
OF SECTION
FOR HEART RESEARCH
1983
Chairman: Motoomi
Nakamura,
Research Institute and Cardiovascular Kyushu University 3-1-1, Maidashi, Japan 812
Denki Bld. Fukuoka, Japan
OF
M.D. of Angiocardiology Clinic, Medical School, Higashi-ku, Fukuoka,
iii
OFFICERS OF THE JAPANESE SECTION SOCIETY FOR HEART RESEARCH Honorary
OF THE INTERNATIONAL
Members: T. Kobayashi, Y. Yamamura,
Tokyo Osaka
President: Y. Ito, Executive
Tokyo
Secretary: M. Nagano,
Members
of
Executive
Tokyo
Committee: S. M. H. C. H. H. S. F. S. E. T.
Ebashi, Tokyo Goto, Fukuoka Irisawa, Okazaki Kawai, Kyoto Mashima, Tokyo Manabe, Osaka Onishi, Osaka Takenaka, Kumamoto Toyama, Osaka Yamada, Tokyo Yamano, Osaka
Secretariat: Department of Internal Medicine School of Medicine Aoto Hospital, Jikei University, Tokyo 125, Katsushika-ku, Aoto 6-41-2, Japan
Friday,
4 November
1983
(1l:OOa.m.
to
12noon)
ROOM A
Chairman:
SPECIAL
LECTURE
Motoomi
Nakamura,
Fukuoka
MECHANISMUS OF THE MAMMALIAN CARDIAC PACEMAKER. H. Irisawa. Institute for Physiological Science, Okazaki, Japan. Friday,
4 November
1983
(2:3Op.m.
National
to 5:OOp.m.)
ROOM A SYMPOSIUM ROLE OF CALCIUM IN FUNCTION AND METABOLISM AND INJURED MYOCARDIUM Chairman:
Tsuguhisa
Ehara
and Hideo
Kanaide,
OF NORMAL Fukuoka
lONlC MECHANISM UNDERLYING POST-ACETYLCHOLINE POTENTIATION OF CATECHOLAMINF RESPONSE IN MAMMALIAN MYOCARDIUM. T. Ehara, T. Mitsuiye. Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. MEASUREMENT OF INTRACELLULAR Ca TRANSIENTS IN CARDIAC MUSCLE WITH AEQUORIN. S. Kurihara, M. Konishi. Department of Physiol., The Jikei Univ. Sch. of Med., Tokyo, Japan. CALCIUM TRANSPORT MECHANISMS IN THE CARDIAC SARCOLEMMA AND SARCOPLASMIC kETICULUM. M. Kadoma, M. Tada. The First Department of Medicine, Osaka University School of Medicine, Osaka, Japan. ELECTROPHYSIOLOGY OF THE HYPOXIC CARDIAC MUSCLE. J. Toyama, T. Furuta, T. Anno. Cardiovascular Division, Research Institute of Enviromental Medicine, Nagoya University, Nagoya, Japan. CALCIUM IONS AS A POTENTlATER OF MYOCARDIAL DEGRADATION AND CELL DEATH UNDER HYPOXIA: A new quantificantion method for cell injury.
T. Toyo-oka, N. Nakamura*, Hosoda. Dept. of Cardiol., Tokyo Metropolitan Inst. of Sci., Sch. of Med., Tsukuba
M. Kitahara*, T. Tanaka*, T. Masakiij, S. Jichi Med. Sch., Tochigi, *Muscle Res. Sec., Med. Sci., Tokyo and #Inst. of Basic Med. Univ., Ibaraki, Japan.
EARLY CHANGES IN ENERGY METABOLISM AND CALCIUM TRANSPORT DURING THE CALCIUM PARADOX. H. Kanaide, H. Meno, M. Okada, M. Nakamura. Research Institute of Angiocardiology and Cardiovascular Clinic, School of Medicine, Kyushu University, Fukuoka, Japan. Friday,
4 November
1983
(9:30a.m.
to 1l:OOa.m.)
ROOM A SESSION
1
COMPARATIVE BINDING STUDY OF 'H-PRAZOSIN AND 3H-NITRENDIPINE TO Y. Watanabe*, Y. Kamino**, H. Abe. MYOCARDIAL MEMBRANE. T. Kagiya, Department of Pharmacology I*, Intensive Care Unit** and Internal Medicine I, Osaka University School of Med., Osaka, Japan. (1) 'H DILTIAZEM BINDING TO CARDIAC MUSCLE MEMBRANES IS DEPENDENT ON THE CONCENTRATION OF DIVALENT CATIONS. U. Ikeda, T. Toyo-oka, S. Hosoda, S. Harigaya*. Dept. of Cardiol., Jichi Med. School, Tochigi and *Tanabe Phar. Inst., Saitama, Japan. (2) PROTECTIVE EFFECT OF VERAPAMIL ON ISCHEMIC MYOCARDIAL DAMAGE. Y. Miyazaki, S. Nagai, K. Ogawa, T. Satake, S. Sugiyama*, T. Ozawa*. of Internal Medicine and *Biomedical Chemistry, Faculty of Depts. Medicine, University of Nagoya, Nagoya, Japan. (3) EFFECT OF Ca-ANTAGONIST "DILTIAZEM" ON THE ACUTE ISCHEMIC MYOCARDIAL INJURY. T. Katagiri, E. Iijima, S. Sekita, N. Konno, T. Yanagishita, The Third Kanaya, K. Akiyama, Y. Kobayashi, Y. Takeyama, H. Niitani. Department of Internal Medicine, Showa University, Tokyo, Japan. (4) ANTIARRHYTHMIC AND MYOCARDIAL METABOLIC EFFECTS OF VERAPAMIL DURING A. Kobayashi, Y. Suzuki, Y. Masumura, CORONARY ARTERIAL REPERFUSION. Third Hayashi, M. Abe, K. Nishihara, T. Kamikawa, N. Yamazaki. Hamamatsu University School of Department of Internal Medicine, Medicine, Hamamatsu, Japan.(S)
H.
H.
Vii
DIRECT EFFECT OF OUABAIN AND DILTIAZEM ACTION ON CULTURED SINGLE HEART The 3rd Dep. of CELLS. T. Samoto, S. Yoneda, N. Ohte, T. Katoh. Internal Medicine, Nagoya City University Medical School, Nagoya, Japan. Friday,
4 November
1983
(9:30a.m.
to
1l:OOa.m.)
ROOM B SESSION
2
EFFECTS OF CATECHOLAMINE ON K-RELATED CURRENTS OF THE BULLFROG ATRIAL MUSCLE. T. Hyodo, K. Ikeda, M. Goto. Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.('l) AN ANALYSIS OF CHANGES IN RESTING MEMBRANE POTENTIAL INDUCED BY HIGH-RATE STIMULATION IN FROG ATRIA. T. Fujino, M. Goto. Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. (8) EFFECTS OF LOW pH ON THE Na CURRENT (I ) AND THE SLOW INWARD CURRENT ) IN ISOLATED, SINGLEN!?AT VENTRICULAR CELLS. A. ~~@~i~S6.a~~t:Ba Dept. of Physiology, Faculty of Medicine, Kyushu Univ., Fukuoka, Japan. (9) REQUENCY-DEPENDENT ACTION OF GONIOPORA PROPERTIES OF BULLFROG ATRIAL MUSCLE. Fujiwara. Department of Pharmacology, Department of Pharmacology, Faculty of Kyoto, Japan. (10)
TOXIN ON ELECTROMECHANICAL M. Noda, I. Muramatsu, M. Fukui Medical School, Fukui, Medicine, Kyoto University,
and
ROLE OF VOLTAGE DEPENDENT Na-Ca EXCHANGE MECHANISM FOR Ca ACCUMULATION IN THE STORE SITE OF THE GUINEA PIG VENTRICULAR MUSCLE. M. Konishi, S. Kurihara, T. Sakai. Dept. of Physiol., The Jikei University School of Medicine, Tokyo, Japan. (11) CHANGES OF CELLULAR INTERNAL RESISTANCE BY ACETYLSTROPHANTHIDIN. K. Endou, H. Yamamoto, T. Sato, *T. Sawanobori, M. Hiraoka. Dept. of Medicine, Kitasato University, Kanagawa, *Dept. of Cardiovascular Diseases, Tokyo Medical and Dental University, Tokyo, Japan. (12) Friday,
4 November
1983
(9:30a.m.
to 1l:OOa.m.)
16
Viii
ROOM C SESSION 3 MYOCARDIAL CARNITINE DEFICIENCY IN CHRONIC HEART FAILURE AND IN HYPERTROPHIED HEART. Y. Masumura, Y. Suzuki, A. Kobayashi, T. Kamikawa, H. Hayashi, K. Nishihara, M. Abe, N. Yamamzaki. Third Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan. (13) EFFECTS OF l-PROPIONYL CARNITLNE ON ELECTRICAL AND MECHANICAL PROPERTIES OF GUINEA PIG VENTRICULAR MUSCLE AND CANINE PURKINJE FIBERS. M. Aomine, M. Arita, S. Imanishi, T. Kiyosue, T. Shimada*. Dept. of Physiol. and Anat*., Med. Coil. of Oita, Oita, Japan. (14) ANTIARRHYTHMIC EFFECTS OF L-CARNITINE AND ACETYL-L-CARNITINE AGAINST VENTRICULAR ARRHYTHMIA INDUCED BY TWO-STAGE CORONARY LIGATION. K. Matsui, N. Takatsuka*, T. Shibuya**, M. Nakazawa, K. Takeda, S. Imai. Department of Pharmacology and **College of Bio-Medical Technology, Niigata University School of Medicine, Niigata and *Earth Cehmical Co., Ltd., Ako, Japan (15) ELECTROPHYSIOLOGICAL EFFECTS OF L-CARNITINE ON HYPOXIC CANINE PAPILLARY MUSCLE. H. Hayashi, Y. Suzuki, M. Abe, K. Nishihara, Y. Masumura, T. Kamikawa, A. Kobayashi, N. Yamazaki. The Third Department of Internal Medicine, Hammatsu University School of Medicine, Hamamatsu, Japan. (16) ANTIARRHYTHMIC EFFECT OF l-CARNITINE. Miyazaki", S. Nagai*, T. Ozawa. Depts. *Internal Medicine, Faculty of Medicine, Japan. (17)
S. Sugiyama, of Biomedical University
M. Hattori*, Chemistry of Nagoya,
Y. and Nagoya,
LONG-CHAIN ACYL-COA AND MITOCHONDRIAL DYSFUNCTION. S. Nagai, Y. Miyazaki, M. Hattori, K. Ogawa, T. Satake, S. Sugiyama*, T. Ozawa*. Depts. of Internal Medicine and *Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Nagoya, Japan. (18) Friday,
4 November
1983
(1:OOp.m.
ROOM A SESSION 4
to 2:30p.m.)
ix
TISSUE COENZYMEQlQ LEVEL IN OPEN HEART SURGERY. Sunamori, J. Amano, A. Suzuki. Thoracic-Cardiovasc & Dent. Univ., Tokyo. Japan. (19)
T. Okamura, Surgery.,
M. Tokyo
Med
ENDOGENOUS COENZYME Q AND ' ) IN THE MURINE HEART WITH VIRAL MYOCARDlTIS ANDgEFFEC~oO;C~~8G~~~U~%oQ ON THE MYOCARDITIS. Y. Kitaura, H. Morita, H. Deguchi, M. Kodaka, K. If? awamura. The 3rd Div., Dept. of Int. Med., Osaka Medical College, Takatsuki, Osaka, Japan. (20) k STUDY ON MYOCARDIAL ENERGY METABOLISM IN ISCHEMIC HEART DISEASES THE EFFECTS BY A LARGE DOSE ADMINISTRATION OF CoQ M. Kato, M. Koh, Y. Fukuhara, A. Mikuniya, T. Kanazawa, K . OnACiera . The Second Department of Internal Medicine, Hirosaki University, Hirosaki, Japan.
(2.1
RESTORATIVE EFFECT OF CoQ ON REDUCED POSITIVE INOTROPIC ACTION OF STROPHANTHIDIN ON HYPOXIC%YOCARDiUM. R. Kamei, I. Imanaga, M. Kuroiwa, T. Miyase. Dept. of Physiol., School of Med., Fukuoka Univ., Fukuoka, Japan. (22) PROTECTIVE EFFECTS OF COENZYME-Q ON THE DERANGEMENT OF MYOCARDIAL CALClUM AND CONTRACTILITY IN THY#!TOXIC RABBIT. T. Miyazaki, Y. Ito, Tamada, J. Sasaki, E. Komoto, Y. Ueba*, H. Fukuzaki. Dept of Intern. Med., Div. I, Kobe Univ. *Sch. of Allied Med. Sci., Kobe Univ., Kobe, .Japan. (23)
K.
PROlECTIVE ACTION OF PROSTACYCLIN FOR OXYGEN PARADOX. I. Kimura, H. Okamori, K. Nakamura, M. Yasumi, A. Kizu, H. Ijichi. 2nd Department of Internal Medicine, Kyoto Prefectural Univerisy of Medicine, Kyoto, .Japan. (24) Firday,
4 November
1983
(1:OOp.m.
to 2:30p.m.)
ROOM B SESSION 5 1NOTROPIC STATE-INDUCED MOLECULAR ALTERATION OF ISOMYOSIN SUBFRAGMENTOF RABBIT AND CANINE HEARTS. IMMUNOLOGICAL PROPERTIES OF 90,000 DALTON-HEAVY AND 27,000 DALTON-LIGHT CHAINS OF ISOSUBFRAGMENT-1. S. Ueda, E. Tsuchimochi, K. Yamaoki, R. Nagai, K. Imataka, C. Chu, Y. Yazaki. The Thrid Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan. (25)
X
SERIAL CHANGES IN SERUM CARDIAC MYOSIN LIGHT CHAIN I AFTER CORONARY REPERFUSION IN ACUTE MYOCARDIAL INFARCTION. PI. Isobe, R. Nagai, S. Ueda, Y. Yazaki, T. Yamaguchi*, K. Machii*. Third Dept. of Int. Med. Univ. of Tokyo, *Mitsui Memorial Hospital, Tokyo, Japan. (26) CALCIUM-ACTIVATED NEUTRAL PROTEASE (CANP) Y. Yamaoki, Y. Takayama, A. Seki, J. Fujii, for Adult Diseases, Asahi Life Foundation, Department of Internal Medicine, University
IN ISCHEMIC CANINE MYOCARDIUM. Y. Yazaki** The Institute Tokyo, and The Third of Tokyo, Tokyo, Japan. (27)
DEGRADATION PROCESS OF CELLULAR ELEMENTS IN THE INFARCTED MYOCARDIUM AND EFFECT OF PROTEASE-INHIBITER ON THE PROCESS. N. Shibata, H. Akagami, K. The Center for Adult Disease, Osaka, Okamoto. Dep. of Cardiology, Japan. (28 ) CARDIAC CONTRACTILE PROTEINS OF HYPERTENSIVE-DIABETIC Department of Internal Kazama, T. Ohkubo, M. Nagano. Univ., School of Medicine, Tokyo, Japan. (29)
RAT. M. Kato, Medicine, Jikei
PRODUCTION OF A NOVEL CORTICOSTEROID, 18, 19-DIHYDROXYDEOXYCORTICOSTERONE(18, 19-diOH-DOC), BY ADRENAL TISSUES. M. Okamoto, Momoi, S. Fujii, T. Yamano. Department of Biochemistry, Osaka University Medical School, Osaka, Japan. (30) Friday,
4 November
1983
(1:OOp.m.
E.
K.
to 2:30p.m.)
ROOM C SESSION 6 BETA-ADRENERGIC RECEPTOR IN HYPERTROPHIED RAT HEART INDUCED BY AORTIC BANDING AND DOCA-SALT LOADING WITH SPECIAL REFFERENCE TO CATECHOLAMINES. H. Okamori, M. Yasumi, I. Kimura, M. Maeda, K. Nakamura, A. Kusaba, A. Kizu, H. Ijichi. 2nd Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan. (31) EFFECTS 0~ DIBUTYRYL cYcLIc GMP (DBcGMP) 0~ CANINE CARDIOVASCULAR K. Imura, K. Ogawa, T. Satake. The 2nd Department of Internal SYSTEM. Medicine Nagoya University School of Medicine, Nagoya Japan. (32)
Xi
THE EFFECT OF CYCLIC-GMP IN ATRIAL FIBRILLATION. T. Uno, H. Kanayama, K. Imura, K. Ogawa, T. Satake. The 2nd Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan. (33) EFFECTS OF DIBUTYRYL CYCLIC AMP AND ISOPROTERENOL ON THE ACUTELY ISCHEMIC MYOCARDIUM. T. Saito, E. Tokutake, K. Hibiya, I. Watanabe, Saito, Y. Ozawa, M. Hatano. The 2nd Dept. of Medicine, Nihon Univ. (34) School of Medicine, Tokyo, Japan.
S.
EFFECT OF CATECHOLAMINE ON REPERFUSED ISCHEMIC CANlNE MYOCARDIUM. M. Sunamori, T. Okamura, M. Ozeki*, J. Amano, A. Suzuki. Dept of Thoracic (35 1 Surg. Tokyo Med & Dent Univ, and *Juntendo Univ, Tokyo, Japan. CORONARY CIRCULATION AND MYOCARDIAL METABOLISM DURING EXERCISE PATIENTS WITH SYNDROME X. N. Kishima, T. Miyagi, T. Ishihara, Shimada, H. Hamada, K. Kondo, I. Seki. 1st Internal Medicine, Medical College, Takatsuki, Japan. (36) Saturday,
5 November
1983
(9:OOa.m.
IN T. Osaka
to 10:30a.m.)
ROOM A SESSION 7 ENZYMATIC DEFENCE MECHANISM AGAINST DOXORUBICIN-INDUCED CARDIOTOXICITY. E. Nakano, Y. Ueno, H. Ando, K. Shiki, K. Yonenaga, I. Kuboyama, H. Kohno, K. Tokunaga. Department of Cardiac Surgery, Kyushu University, Fukuoka, Japan. (37) TAURINE ON THE CARDIAC FUNCTION IN RABBITS WITH CHRONIC AORTIC REGURGITATION. K. Yamauchi, J. Azuma, N. Awata, H. Ohta, K. Ogura, Sawamura, H. Harada, S. Kishimoto. Third Department of Internal Medicine, Osaka University Medical School, Osaka, Japan. (38)
A.
EFFECT OF SODIUM CONCENTRATION OF THE CARDIOPLEGIC SOLUTION ON THE MYOCARDIAL ENERGY METABOLISM. Y. Ueno, E. Nakano, H. Ando, K. Tokunaga. Department of Cardiac Surgery, Kyushu University, Fukuoka, Japan. (39) EFFECT OF OXYGENATION OF CRYSTALLOID CARDIOPLEGIC SOLUTION. K. Yonenaga, I. Kuboyama, H. Kohno, K. Shiki, K. Tokunaga. Department Cardiac Surgery, Kyushu University, Fukuoka, Japan. (40)
of
xii
MYOCARDIAL PRESERVATION DURING CARDIOPLECIC ARREST: EFFECT OF TEMPERATURE. K. Maruyama*, S. Mochizuki, S. Ishikawa, H. Ozasa, F. Saso, H. Yamaoka, M. Taniguchi, T. Yoshiwara, I. Masuda, M. Shimizu and T. Arai*. Department of Cardiac Sergery* and Medicine, Jikei University School of Medicine, Tokyo. (41) EFFECTS OF NITROGLYCERIN ON MYOCARDIAL CONTRACTILE FORCE DURING ACUTE ISCHEMIA. M. Higuchi, T. Asakawa. Department of Pharmacology, Saga Medical School, Saga, Japan. (42) Saturday,
5 November
1983 (10:30a.m.
to 12noon)
ROOM A SESSION 7 ELECTRON MICROSCOPIC STUDIES ON THE MYOCARDIUM OF NEWBORNAND CULTURED HEART CELLS FROM GENETICALLY DIABETIC KK MICE. H. Fukunaga, K. Saito, T. Matsuoka, T. Kashima, H. Tanaka. The First Dep. of Int. Med., Fat. of Med., Kagoshima University, Kagoshima, Japan. (43) ELECTRON MICROSCOPICSTUDIESOF SARCOPLASMIC RETICULUMIN CARDIAC MUSCLESOF DYSTROPHICMICE. K. Saito, T. Matsuoka, H. Fukunaga, T. Kashima, H. Tanaka. The First Dep. Int. Med., Fat. Med., Kagoshima University, Kagoshima, Japan. (44) ELECTRON MICROSCOPICAUTORADIOGRAPHIC STUDYOF THE RAT HEARTPULSELABELLEDBY INJECTION OF 3H PALMITIC ACID IN VIVO. T. Gotoh. Department of Anatomy, Saitama Medical School, Saitama, Japan. (45) ULTRASTRUCTURAL PROPERTIESOF SPECIALIZED MYOCARDIALCELLSOF SINOATRIAL AND ATRIOVENTRICULAR NODESIN DEVELOPINGGOATS. Y. Sugi and R. Hirakow. Department of Anatomy, Saitana Medical School, Saitama, Japan. (46) FUNCTIONALLIPOPROTEINLIPASE ACTIVITY IN PERFUSEDRATEHEART: EFFECT OF RASTINGAND DIABETES. S. Mochizuki, T. Murase", S. Ishikawa and H. Ozasa. Department of Medicine, Jikei University School of Medicine and University of Tokyo*, Tokyo, Japan. (47 1 ENHANCED SUPPRESSION OF MYOCARDIALSLOWACTION POTENTIALSDURINGHYPOXIA BY FREE FATTY ACID. H. Harada, J. Azuma, H. Hasegawa, H. Ohta, K.
xiii
Yamauchi, K. Ogura, N. Awata, A. Sawamura, S. Kishimoto. Department of Internal Medicine, Osaka Unviersity Medical Japan. (48) Saturday,
5 November
1983
(9:OOa.m.
Third School,
Osaka,
to 10:3Oa.m.)
ROOM B SESSION 9 CARDIAC CONTRACTILE Meno, H. Kanaide, M. Angiocardiology and University, Fukuoka, CARDIAC CONTRACTILITY RETICULLM IN ISCHEMIA Yamamoto, M. Nakamura. Cardiovascular Clinic, (50) Japan.
FUNCTION AND ENERGY METABOLISM Research Okada, M. Nakamura. Cardiovascular Clinic, Faculty Japan. (49)
DURING ISCHEMIA. H. Institute of of Medicine, Kyushu
AND CALCIUM TRANSPORT ACTIVITY OF SARCOPLASMLC AND REPERFUSION. H. Meno, H. Kanaide, M. Research Institute of Angiocaridology and Faculty of Medicine, Kyushu University, Fukuoka,
REVERSIBLE PERIODS FOR HYPOXIA-INDUCED DAMAGE IN CARDIAC FUNCTION AND ENERGY PRODUCTION. S. Takeo, K. Noguchi, M. Sakanashi. Department of Pharmacology, Faculty of Medicine, University of the Ryukyu, Okinawa, Japan. (51) ULTRASTRUCTURAL STUDY OF REPERFUSION EFFECT ON ISCHEMIC MYOCARDIAL INJURY. T. Fukuhara, K. Mitsunami, K. Bito, M. Kinoshita, S. Kawakita. The First Department of Internal Medicine, Shiga University of Medical Science, Shiga Pref., Japan. (52) EFFECT OF L-LYSINE ON THE CARDIAC FUNCTION AND METABOLISM IN HEART LUNG PREPARATION. M. Nagano, K. Takahashi, H. Maeno, A. Komori, T. Shikano. Department of Internal Medicine, Jikei Univ., School of Medicine, Tokyo, Japan. (53) RELATIONSHIP BETWEEN AND REPERFUSION. T. S. Yasui. The First University School of
MYOCARDIAL Kaminishi, Department Medicine,
FUNCTION AND METABOLISM DURING ISCHEMIA M. Oguma, I. Ohta, N. Ohara, K. Tsuiki, of Internal Medicine, Yamagata Yamagata, Japan. (54)
xiv
Saturday,
5 November
1983
(10:30a.m.
to 12noon)
ROOM A SESSION
10
TIME COURSE OF MYOCARDIAL HIGH ENERGY PHOSPHATES AND ORGANIC ACIDS IN DOGS WITH ACUTE ISCHEMIA. T. Hashimoto, B. Itoh, C.L. Chen, T. Matsubara, K. Itoh, N, Hibi, K. Nishimura, T. Kambe, N. Sakamoto, S. Sugiyama*, 'I. Ozawa*, T. Ohki**, A. Saitoh**, K. Ohta**. 3rd Dept. of Intern. Med. and Dept. of Biomed. Chem.*, School of Med., Nagoya Univ., The Bio-Dynamics Res. Instit.**, Nagoya, Japan. (55) IS ISCHEMIA-INDUCED PH DECREASE OF DOG MYOCARDIUM RESPIRATORY OR METABOLIC ACIDOSIS? K. Ichihara, N. Haga, Y. Abiko. Department of Pharmacology, Asahikawa Medical College, Asahikawa, Japan. (56) RIGHT AND LEFT VENTRICULAR OXYGEN METABOLISM IN OPEN-CHEST DOGS. K. Takeda, T. Hyodo, Y. Abe, D. Saito, S. Haraoka, H. Nagashima. The First Department of Internal Medicine, Okayama Unviersity Medical School, Okayama, Japan. (57) HIGH GRADE HYPOXIA IN MYOCARDIAL CELL CULTURES. H. Ishida, F. Ohsuzu, H. Kohara, K. Hosono. National Defense Medical Tokorozawa, Japan. (58)
N. Aosaki, College,
ELECTRICAL ACTIVITY OF CARDIAC CELLS TRANSPLANTED INTO THE RENAL Y. Nishizono, K. CAPSULAR SPACE OF THE RAT AND EFFECTS OF ISCHFMIA. Nishi. Department of Pharmacology, Kumamoto University Medical School, Kumamoto, Japan. (59) MYOCARDIAL Tamura, N. Mori. 2nd Tokushima,
DISORDERS OF HEREDITARILY DIABETIC KK MICE. S. Miyakami, Nagase, S. Kobayashi, H. Sako, T. Kudo, K. Saito, T. Niki, Department of Internal Medicine, Tokushima University, Japan. (60) Saturday,
5 November
1983
(10:OOa.m.
ROOM B SESSION
11
to 0:lsp.m.)
Y. H.
xv
EFFECT OF LIDOCAINE, DISOPYRAMIDE AND PROCAINEAMIDE OF CARDIAC T. Shirai, K. Izumo, S. Hara, H. EXCITABILITY OF RABBITS VENTRICLES. Showa University Fujigaoka Osada, K. Harumi. Cardiovascular Division, Hospital, Yokohama, Japan. (61) CHRONIC AND ACUTE EFFECTS OF AMIODARONE ON THE RABBIT HEART MUSCLES. The 3rd Div., Kadoya, T. Konishi, T. Tamamura, S. Ikeguchi, C. Kawai. Med., Fat. of Med., Kyoto Univ., Kyoto, Japan. (62) Dep. of Int. EFFECTS OF CONTRAST MEDIA AND HYPEROSMOLALITY ON ACTION POTENTIAL OF GUINEA PIG PAPILLARY MUSCLE. M. Sumikawa, Y. Hirata, K. Shimomura. Dept. Int. Med., National Cardiovascular Center, Suita, Osaka, Japan.
M.
(6 3)
EFFECTS OF CO'+ AND DANTROLENE OF ELECTRICAL AND MECHANICAL OSCILLATIONS H. Kinoshita, S. Kawano, M. Hiraoka. IN GUINEA-PIG VENTRICULAR MUSCLES. Dept. Cardiovasc. Dis., MRI, Tokyo Medical and Dental University, Tokyo,
OF (66)
INWARD RECTIFYING PROPERTIES IN SINGLE CHANNEL K+ CURRENT OF ISOLATED GUINEA PIG MYOCARDIAL CELL. J. Taniguchi. Fat. Science, Deet , Biology, Osaka University, Osaka & Dept, Molecular Physiology, National Cardiovascular Center Research Institute, Osaka, Japan. (67) Saturday,
5 November
1983
(10:30a.m.
to 12noon)
ROOM C SESSION
12
THE EFFECTS 0~ SELECTIVE THROMBOXANE SYNTHETASE INHIBITOR (OKY-046) 0~ MYOCARDIAL INFARCT SIZE IN ANESTHETIZED DOGS. M. Moriuchi, M. Tsuji, S. Saito, Y. Tamura, Y. Ozawa, M. Hatano, I. Sakurai*. The 2nd Department
XVI
of Internal Department
Medicine, Nihon University of Pathology, Tokyo, Japan.
School (68 )
of Medicine,
*The
2nd
ELECTROPHYSIOLOGICAL ANALYSES OF THE EFFECTS OF PROSTAGLANDINS ON THE BULLFROG ATRIAL MUSCLES. M. Hachisuga, M. Goto. Department of Physiology, Faculty of Medicine, Fukuoka, Japan. (69) EXCESSIVE THROMBOXANE A2 PRODUCTION DURING EVOLUTING PROCESS IN ACUTE MYOCARDIAL INFARCTION. S. Hoshida, T. Kuzuya, M. Ohmori, M. Yamagishi, H. Matsuda, M. Tada, H. Abe. The First Dept. of Med., Osaka Univ. Sch. of Med., Osaka, Japan. (70) EFFECTS OF SELECTIVE THROMBOXANE A2 SYNTHETASE INHIBITOR (OKY-1518, 046) IN PATIENTS WITH ANGINA PECTORIS. T. Ito, M. Sikano, L.S. Chen, K. Ogawa, T. Satake. The 2nd Dep. of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan. (71) 2+ TENSION IN GLYCERINATED CARDIAC MUSCLE AT VARIOUS Mg AND MgATP CONCENTRATIONS, AND THE TRANSIENT TENSION RESPONSES TO STEP LENGTH C. Kato, T. Horikoshi, K. Yanagisawa. CHANGES. Y. Saeki, Dept. of Physiol., Tsurumi Univ. Sch. of Dent. Med., Yokohama, Japan. (72) MECHANISM OF DIRECT CARDIOSTIMULATING ACTIONS OF HYDRALAZINE. A. Sawamura, J. Azuma, H. Harada, K. Ogura, N. Awata, H. Ohta, K. Yamauchi,. S. Kishimoto. Third Department of Internal Medicine, Osaka University Medical School, Osaka, Japan. (73)
4-5
OF JAPANESE
SOCIETY
November
OF SECTION
FOR HEART RESEARCH
1983
Chairman: Motoomi
Nakamura,
Research Institute and Cardiovascular Kyushu University 3-1-1, Maidashi, Japan 812
Denki Bld. Fukuoka, Japan
OF
M.D. of Angiocardiology Clinic, Medical School, Higashi-ku, Fukuoka,
iii
OFFICERS OF THE JAPANESE SECTION SOCIETY FOR HEART RESEARCH Honorary
OF THE INTERNATIONAL
Members: T. Kobayashi, Y. Yamamura,
Tokyo Osaka
President: Y. Ito, Executive
Tokyo
Secretary: M. Nagano,
Members
of
Executive
Tokyo
Committee: S. M. H. C. H. H. S. F. S. E. T.
Ebashi, Tokyo Goto, Fukuoka Irisawa, Okazaki Kawai, Kyoto Mashima, Tokyo Manabe, Osaka Onishi, Osaka Takenaka, Kumamoto Toyama, Osaka Yamada, Tokyo Yamano, Osaka
Secretariat: Department of Internal Medicine School of Medicine Aoto Hospital, Jikei University, Tokyo 125, Katsushika-ku, Aoto 6-41-2, Japan
Friday,
4 November
1983
(1l:OOa.m.
to
12noon)
ROOM A
Chairman:
SPECIAL
LECTURE
Motoomi
Nakamura,
Fukuoka
MECHANISMUS OF THE MAMMALIAN CARDIAC PACEMAKER. H. Irisawa. Institute for Physiological Science, Okazaki, Japan. Friday,
4 November
1983
(2:3Op.m.
National
to 5:OOp.m.)
ROOM A SYMPOSIUM ROLE OF CALCIUM IN FUNCTION AND METABOLISM AND INJURED MYOCARDIUM Chairman:
Tsuguhisa
Ehara
and Hideo
Kanaide,
OF NORMAL Fukuoka
lONlC MECHANISM UNDERLYING POST-ACETYLCHOLINE POTENTIATION OF CATECHOLAMINF RESPONSE IN MAMMALIAN MYOCARDIUM. T. Ehara, T. Mitsuiye. Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. MEASUREMENT OF INTRACELLULAR Ca TRANSIENTS IN CARDIAC MUSCLE WITH AEQUORIN. S. Kurihara, M. Konishi. Department of Physiol., The Jikei Univ. Sch. of Med., Tokyo, Japan. CALCIUM TRANSPORT MECHANISMS IN THE CARDIAC SARCOLEMMA AND SARCOPLASMIC kETICULUM. M. Kadoma, M. Tada. The First Department of Medicine, Osaka University School of Medicine, Osaka, Japan. ELECTROPHYSIOLOGY OF THE HYPOXIC CARDIAC MUSCLE. J. Toyama, T. Furuta, T. Anno. Cardiovascular Division, Research Institute of Enviromental Medicine, Nagoya University, Nagoya, Japan. CALCIUM IONS AS A POTENTlATER OF MYOCARDIAL DEGRADATION AND CELL DEATH UNDER HYPOXIA: A new quantificantion method for cell injury.
T. Toyo-oka, N. Nakamura*, Hosoda. Dept. of Cardiol., Tokyo Metropolitan Inst. of Sci., Sch. of Med., Tsukuba
M. Kitahara*, T. Tanaka*, T. Masakiij, S. Jichi Med. Sch., Tochigi, *Muscle Res. Sec., Med. Sci., Tokyo and #Inst. of Basic Med. Univ., Ibaraki, Japan.
EARLY CHANGES IN ENERGY METABOLISM AND CALCIUM TRANSPORT DURING THE CALCIUM PARADOX. H. Kanaide, H. Meno, M. Okada, M. Nakamura. Research Institute of Angiocardiology and Cardiovascular Clinic, School of Medicine, Kyushu University, Fukuoka, Japan. Friday,
4 November
1983
(9:30a.m.
to 1l:OOa.m.)
ROOM A SESSION
1
COMPARATIVE BINDING STUDY OF 'H-PRAZOSIN AND 3H-NITRENDIPINE TO Y. Watanabe*, Y. Kamino**, H. Abe. MYOCARDIAL MEMBRANE. T. Kagiya, Department of Pharmacology I*, Intensive Care Unit** and Internal Medicine I, Osaka University School of Med., Osaka, Japan. (1) 'H DILTIAZEM BINDING TO CARDIAC MUSCLE MEMBRANES IS DEPENDENT ON THE CONCENTRATION OF DIVALENT CATIONS. U. Ikeda, T. Toyo-oka, S. Hosoda, S. Harigaya*. Dept. of Cardiol., Jichi Med. School, Tochigi and *Tanabe Phar. Inst., Saitama, Japan. (2) PROTECTIVE EFFECT OF VERAPAMIL ON ISCHEMIC MYOCARDIAL DAMAGE. Y. Miyazaki, S. Nagai, K. Ogawa, T. Satake, S. Sugiyama*, T. Ozawa*. of Internal Medicine and *Biomedical Chemistry, Faculty of Depts. Medicine, University of Nagoya, Nagoya, Japan. (3) EFFECT OF Ca-ANTAGONIST "DILTIAZEM" ON THE ACUTE ISCHEMIC MYOCARDIAL INJURY. T. Katagiri, E. Iijima, S. Sekita, N. Konno, T. Yanagishita, The Third Kanaya, K. Akiyama, Y. Kobayashi, Y. Takeyama, H. Niitani. Department of Internal Medicine, Showa University, Tokyo, Japan. (4) ANTIARRHYTHMIC AND MYOCARDIAL METABOLIC EFFECTS OF VERAPAMIL DURING A. Kobayashi, Y. Suzuki, Y. Masumura, CORONARY ARTERIAL REPERFUSION. Third Hayashi, M. Abe, K. Nishihara, T. Kamikawa, N. Yamazaki. Hamamatsu University School of Department of Internal Medicine, Medicine, Hamamatsu, Japan.(S)
H.
H.
Vii
DIRECT EFFECT OF OUABAIN AND DILTIAZEM ACTION ON CULTURED SINGLE HEART The 3rd Dep. of CELLS. T. Samoto, S. Yoneda, N. Ohte, T. Katoh. Internal Medicine, Nagoya City University Medical School, Nagoya, Japan. Friday,
4 November
1983
(9:30a.m.
to
1l:OOa.m.)
ROOM B SESSION
2
EFFECTS OF CATECHOLAMINE ON K-RELATED CURRENTS OF THE BULLFROG ATRIAL MUSCLE. T. Hyodo, K. Ikeda, M. Goto. Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.('l) AN ANALYSIS OF CHANGES IN RESTING MEMBRANE POTENTIAL INDUCED BY HIGH-RATE STIMULATION IN FROG ATRIA. T. Fujino, M. Goto. Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. (8) EFFECTS OF LOW pH ON THE Na CURRENT (I ) AND THE SLOW INWARD CURRENT ) IN ISOLATED, SINGLEN!?AT VENTRICULAR CELLS. A. ~~@~i~S6.a~~t:Ba Dept. of Physiology, Faculty of Medicine, Kyushu Univ., Fukuoka, Japan. (9) REQUENCY-DEPENDENT ACTION OF GONIOPORA PROPERTIES OF BULLFROG ATRIAL MUSCLE. Fujiwara. Department of Pharmacology, Department of Pharmacology, Faculty of Kyoto, Japan. (10)
TOXIN ON ELECTROMECHANICAL M. Noda, I. Muramatsu, M. Fukui Medical School, Fukui, Medicine, Kyoto University,
and
ROLE OF VOLTAGE DEPENDENT Na-Ca EXCHANGE MECHANISM FOR Ca ACCUMULATION IN THE STORE SITE OF THE GUINEA PIG VENTRICULAR MUSCLE. M. Konishi, S. Kurihara, T. Sakai. Dept. of Physiol., The Jikei University School of Medicine, Tokyo, Japan. (11) CHANGES OF CELLULAR INTERNAL RESISTANCE BY ACETYLSTROPHANTHIDIN. K. Endou, H. Yamamoto, T. Sato, *T. Sawanobori, M. Hiraoka. Dept. of Medicine, Kitasato University, Kanagawa, *Dept. of Cardiovascular Diseases, Tokyo Medical and Dental University, Tokyo, Japan. (12) Friday,
4 November
1983
(9:30a.m.
to 1l:OOa.m.)
16
Viii
ROOM C SESSION 3 MYOCARDIAL CARNITINE DEFICIENCY IN CHRONIC HEART FAILURE AND IN HYPERTROPHIED HEART. Y. Masumura, Y. Suzuki, A. Kobayashi, T. Kamikawa, H. Hayashi, K. Nishihara, M. Abe, N. Yamamzaki. Third Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan. (13) EFFECTS OF l-PROPIONYL CARNITLNE ON ELECTRICAL AND MECHANICAL PROPERTIES OF GUINEA PIG VENTRICULAR MUSCLE AND CANINE PURKINJE FIBERS. M. Aomine, M. Arita, S. Imanishi, T. Kiyosue, T. Shimada*. Dept. of Physiol. and Anat*., Med. Coil. of Oita, Oita, Japan. (14) ANTIARRHYTHMIC EFFECTS OF L-CARNITINE AND ACETYL-L-CARNITINE AGAINST VENTRICULAR ARRHYTHMIA INDUCED BY TWO-STAGE CORONARY LIGATION. K. Matsui, N. Takatsuka*, T. Shibuya**, M. Nakazawa, K. Takeda, S. Imai. Department of Pharmacology and **College of Bio-Medical Technology, Niigata University School of Medicine, Niigata and *Earth Cehmical Co., Ltd., Ako, Japan (15) ELECTROPHYSIOLOGICAL EFFECTS OF L-CARNITINE ON HYPOXIC CANINE PAPILLARY MUSCLE. H. Hayashi, Y. Suzuki, M. Abe, K. Nishihara, Y. Masumura, T. Kamikawa, A. Kobayashi, N. Yamazaki. The Third Department of Internal Medicine, Hammatsu University School of Medicine, Hamamatsu, Japan. (16) ANTIARRHYTHMIC EFFECT OF l-CARNITINE. Miyazaki", S. Nagai*, T. Ozawa. Depts. *Internal Medicine, Faculty of Medicine, Japan. (17)
S. Sugiyama, of Biomedical University
M. Hattori*, Chemistry of Nagoya,
Y. and Nagoya,
LONG-CHAIN ACYL-COA AND MITOCHONDRIAL DYSFUNCTION. S. Nagai, Y. Miyazaki, M. Hattori, K. Ogawa, T. Satake, S. Sugiyama*, T. Ozawa*. Depts. of Internal Medicine and *Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Nagoya, Japan. (18) Friday,
4 November
1983
(1:OOp.m.
ROOM A SESSION 4
to 2:30p.m.)
ix
TISSUE COENZYMEQlQ LEVEL IN OPEN HEART SURGERY. Sunamori, J. Amano, A. Suzuki. Thoracic-Cardiovasc & Dent. Univ., Tokyo. Japan. (19)
T. Okamura, Surgery.,
M. Tokyo
Med
ENDOGENOUS COENZYME Q AND ' ) IN THE MURINE HEART WITH VIRAL MYOCARDlTIS ANDgEFFEC~oO;C~~8G~~~U~%oQ ON THE MYOCARDITIS. Y. Kitaura, H. Morita, H. Deguchi, M. Kodaka, K. If? awamura. The 3rd Div., Dept. of Int. Med., Osaka Medical College, Takatsuki, Osaka, Japan. (20) k STUDY ON MYOCARDIAL ENERGY METABOLISM IN ISCHEMIC HEART DISEASES THE EFFECTS BY A LARGE DOSE ADMINISTRATION OF CoQ M. Kato, M. Koh, Y. Fukuhara, A. Mikuniya, T. Kanazawa, K . OnACiera . The Second Department of Internal Medicine, Hirosaki University, Hirosaki, Japan.
(2.1
RESTORATIVE EFFECT OF CoQ ON REDUCED POSITIVE INOTROPIC ACTION OF STROPHANTHIDIN ON HYPOXIC%YOCARDiUM. R. Kamei, I. Imanaga, M. Kuroiwa, T. Miyase. Dept. of Physiol., School of Med., Fukuoka Univ., Fukuoka, Japan. (22) PROTECTIVE EFFECTS OF COENZYME-Q ON THE DERANGEMENT OF MYOCARDIAL CALClUM AND CONTRACTILITY IN THY#!TOXIC RABBIT. T. Miyazaki, Y. Ito, Tamada, J. Sasaki, E. Komoto, Y. Ueba*, H. Fukuzaki. Dept of Intern. Med., Div. I, Kobe Univ. *Sch. of Allied Med. Sci., Kobe Univ., Kobe, .Japan. (23)
K.
PROlECTIVE ACTION OF PROSTACYCLIN FOR OXYGEN PARADOX. I. Kimura, H. Okamori, K. Nakamura, M. Yasumi, A. Kizu, H. Ijichi. 2nd Department of Internal Medicine, Kyoto Prefectural Univerisy of Medicine, Kyoto, .Japan. (24) Firday,
4 November
1983
(1:OOp.m.
to 2:30p.m.)
ROOM B SESSION 5 1NOTROPIC STATE-INDUCED MOLECULAR ALTERATION OF ISOMYOSIN SUBFRAGMENTOF RABBIT AND CANINE HEARTS. IMMUNOLOGICAL PROPERTIES OF 90,000 DALTON-HEAVY AND 27,000 DALTON-LIGHT CHAINS OF ISOSUBFRAGMENT-1. S. Ueda, E. Tsuchimochi, K. Yamaoki, R. Nagai, K. Imataka, C. Chu, Y. Yazaki. The Thrid Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan. (25)
X
SERIAL CHANGES IN SERUM CARDIAC MYOSIN LIGHT CHAIN I AFTER CORONARY REPERFUSION IN ACUTE MYOCARDIAL INFARCTION. PI. Isobe, R. Nagai, S. Ueda, Y. Yazaki, T. Yamaguchi*, K. Machii*. Third Dept. of Int. Med. Univ. of Tokyo, *Mitsui Memorial Hospital, Tokyo, Japan. (26) CALCIUM-ACTIVATED NEUTRAL PROTEASE (CANP) Y. Yamaoki, Y. Takayama, A. Seki, J. Fujii, for Adult Diseases, Asahi Life Foundation, Department of Internal Medicine, University
IN ISCHEMIC CANINE MYOCARDIUM. Y. Yazaki** The Institute Tokyo, and The Third of Tokyo, Tokyo, Japan. (27)
DEGRADATION PROCESS OF CELLULAR ELEMENTS IN THE INFARCTED MYOCARDIUM AND EFFECT OF PROTEASE-INHIBITER ON THE PROCESS. N. Shibata, H. Akagami, K. The Center for Adult Disease, Osaka, Okamoto. Dep. of Cardiology, Japan. (28 ) CARDIAC CONTRACTILE PROTEINS OF HYPERTENSIVE-DIABETIC Department of Internal Kazama, T. Ohkubo, M. Nagano. Univ., School of Medicine, Tokyo, Japan. (29)
RAT. M. Kato, Medicine, Jikei
PRODUCTION OF A NOVEL CORTICOSTEROID, 18, 19-DIHYDROXYDEOXYCORTICOSTERONE(18, 19-diOH-DOC), BY ADRENAL TISSUES. M. Okamoto, Momoi, S. Fujii, T. Yamano. Department of Biochemistry, Osaka University Medical School, Osaka, Japan. (30) Friday,
4 November
1983
(1:OOp.m.
E.
K.
to 2:30p.m.)
ROOM C SESSION 6 BETA-ADRENERGIC RECEPTOR IN HYPERTROPHIED RAT HEART INDUCED BY AORTIC BANDING AND DOCA-SALT LOADING WITH SPECIAL REFFERENCE TO CATECHOLAMINES. H. Okamori, M. Yasumi, I. Kimura, M. Maeda, K. Nakamura, A. Kusaba, A. Kizu, H. Ijichi. 2nd Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan. (31) EFFECTS 0~ DIBUTYRYL cYcLIc GMP (DBcGMP) 0~ CANINE CARDIOVASCULAR K. Imura, K. Ogawa, T. Satake. The 2nd Department of Internal SYSTEM. Medicine Nagoya University School of Medicine, Nagoya Japan. (32)
Xi
THE EFFECT OF CYCLIC-GMP IN ATRIAL FIBRILLATION. T. Uno, H. Kanayama, K. Imura, K. Ogawa, T. Satake. The 2nd Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan. (33) EFFECTS OF DIBUTYRYL CYCLIC AMP AND ISOPROTERENOL ON THE ACUTELY ISCHEMIC MYOCARDIUM. T. Saito, E. Tokutake, K. Hibiya, I. Watanabe, Saito, Y. Ozawa, M. Hatano. The 2nd Dept. of Medicine, Nihon Univ. (34) School of Medicine, Tokyo, Japan.
S.
EFFECT OF CATECHOLAMINE ON REPERFUSED ISCHEMIC CANlNE MYOCARDIUM. M. Sunamori, T. Okamura, M. Ozeki*, J. Amano, A. Suzuki. Dept of Thoracic (35 1 Surg. Tokyo Med & Dent Univ, and *Juntendo Univ, Tokyo, Japan. CORONARY CIRCULATION AND MYOCARDIAL METABOLISM DURING EXERCISE PATIENTS WITH SYNDROME X. N. Kishima, T. Miyagi, T. Ishihara, Shimada, H. Hamada, K. Kondo, I. Seki. 1st Internal Medicine, Medical College, Takatsuki, Japan. (36) Saturday,
5 November
1983
(9:OOa.m.
IN T. Osaka
to 10:30a.m.)
ROOM A SESSION 7 ENZYMATIC DEFENCE MECHANISM AGAINST DOXORUBICIN-INDUCED CARDIOTOXICITY. E. Nakano, Y. Ueno, H. Ando, K. Shiki, K. Yonenaga, I. Kuboyama, H. Kohno, K. Tokunaga. Department of Cardiac Surgery, Kyushu University, Fukuoka, Japan. (37) TAURINE ON THE CARDIAC FUNCTION IN RABBITS WITH CHRONIC AORTIC REGURGITATION. K. Yamauchi, J. Azuma, N. Awata, H. Ohta, K. Ogura, Sawamura, H. Harada, S. Kishimoto. Third Department of Internal Medicine, Osaka University Medical School, Osaka, Japan. (38)
A.
EFFECT OF SODIUM CONCENTRATION OF THE CARDIOPLEGIC SOLUTION ON THE MYOCARDIAL ENERGY METABOLISM. Y. Ueno, E. Nakano, H. Ando, K. Tokunaga. Department of Cardiac Surgery, Kyushu University, Fukuoka, Japan. (39) EFFECT OF OXYGENATION OF CRYSTALLOID CARDIOPLEGIC SOLUTION. K. Yonenaga, I. Kuboyama, H. Kohno, K. Shiki, K. Tokunaga. Department Cardiac Surgery, Kyushu University, Fukuoka, Japan. (40)
of
xii
MYOCARDIAL PRESERVATION DURING CARDIOPLECIC ARREST: EFFECT OF TEMPERATURE. K. Maruyama*, S. Mochizuki, S. Ishikawa, H. Ozasa, F. Saso, H. Yamaoka, M. Taniguchi, T. Yoshiwara, I. Masuda, M. Shimizu and T. Arai*. Department of Cardiac Sergery* and Medicine, Jikei University School of Medicine, Tokyo. (41) EFFECTS OF NITROGLYCERIN ON MYOCARDIAL CONTRACTILE FORCE DURING ACUTE ISCHEMIA. M. Higuchi, T. Asakawa. Department of Pharmacology, Saga Medical School, Saga, Japan. (42) Saturday,
5 November
1983 (10:30a.m.
to 12noon)
ROOM A SESSION 7 ELECTRON MICROSCOPIC STUDIES ON THE MYOCARDIUM OF NEWBORNAND CULTURED HEART CELLS FROM GENETICALLY DIABETIC KK MICE. H. Fukunaga, K. Saito, T. Matsuoka, T. Kashima, H. Tanaka. The First Dep. of Int. Med., Fat. of Med., Kagoshima University, Kagoshima, Japan. (43) ELECTRON MICROSCOPICSTUDIESOF SARCOPLASMIC RETICULUMIN CARDIAC MUSCLESOF DYSTROPHICMICE. K. Saito, T. Matsuoka, H. Fukunaga, T. Kashima, H. Tanaka. The First Dep. Int. Med., Fat. Med., Kagoshima University, Kagoshima, Japan. (44) ELECTRON MICROSCOPICAUTORADIOGRAPHIC STUDYOF THE RAT HEARTPULSELABELLEDBY INJECTION OF 3H PALMITIC ACID IN VIVO. T. Gotoh. Department of Anatomy, Saitama Medical School, Saitama, Japan. (45) ULTRASTRUCTURAL PROPERTIESOF SPECIALIZED MYOCARDIALCELLSOF SINOATRIAL AND ATRIOVENTRICULAR NODESIN DEVELOPINGGOATS. Y. Sugi and R. Hirakow. Department of Anatomy, Saitana Medical School, Saitama, Japan. (46) FUNCTIONALLIPOPROTEINLIPASE ACTIVITY IN PERFUSEDRATEHEART: EFFECT OF RASTINGAND DIABETES. S. Mochizuki, T. Murase", S. Ishikawa and H. Ozasa. Department of Medicine, Jikei University School of Medicine and University of Tokyo*, Tokyo, Japan. (47 1 ENHANCED SUPPRESSION OF MYOCARDIALSLOWACTION POTENTIALSDURINGHYPOXIA BY FREE FATTY ACID. H. Harada, J. Azuma, H. Hasegawa, H. Ohta, K.
xiii
Yamauchi, K. Ogura, N. Awata, A. Sawamura, S. Kishimoto. Department of Internal Medicine, Osaka Unviersity Medical Japan. (48) Saturday,
5 November
1983
(9:OOa.m.
Third School,
Osaka,
to 10:3Oa.m.)
ROOM B SESSION 9 CARDIAC CONTRACTILE Meno, H. Kanaide, M. Angiocardiology and University, Fukuoka, CARDIAC CONTRACTILITY RETICULLM IN ISCHEMIA Yamamoto, M. Nakamura. Cardiovascular Clinic, (50) Japan.
FUNCTION AND ENERGY METABOLISM Research Okada, M. Nakamura. Cardiovascular Clinic, Faculty Japan. (49)
DURING ISCHEMIA. H. Institute of of Medicine, Kyushu
AND CALCIUM TRANSPORT ACTIVITY OF SARCOPLASMLC AND REPERFUSION. H. Meno, H. Kanaide, M. Research Institute of Angiocaridology and Faculty of Medicine, Kyushu University, Fukuoka,
REVERSIBLE PERIODS FOR HYPOXIA-INDUCED DAMAGE IN CARDIAC FUNCTION AND ENERGY PRODUCTION. S. Takeo, K. Noguchi, M. Sakanashi. Department of Pharmacology, Faculty of Medicine, University of the Ryukyu, Okinawa, Japan. (51) ULTRASTRUCTURAL STUDY OF REPERFUSION EFFECT ON ISCHEMIC MYOCARDIAL INJURY. T. Fukuhara, K. Mitsunami, K. Bito, M. Kinoshita, S. Kawakita. The First Department of Internal Medicine, Shiga University of Medical Science, Shiga Pref., Japan. (52) EFFECT OF L-LYSINE ON THE CARDIAC FUNCTION AND METABOLISM IN HEART LUNG PREPARATION. M. Nagano, K. Takahashi, H. Maeno, A. Komori, T. Shikano. Department of Internal Medicine, Jikei Univ., School of Medicine, Tokyo, Japan. (53) RELATIONSHIP BETWEEN AND REPERFUSION. T. S. Yasui. The First University School of
MYOCARDIAL Kaminishi, Department Medicine,
FUNCTION AND METABOLISM DURING ISCHEMIA M. Oguma, I. Ohta, N. Ohara, K. Tsuiki, of Internal Medicine, Yamagata Yamagata, Japan. (54)
xiv
Saturday,
5 November
1983
(10:30a.m.
to 12noon)
ROOM A SESSION
10
TIME COURSE OF MYOCARDIAL HIGH ENERGY PHOSPHATES AND ORGANIC ACIDS IN DOGS WITH ACUTE ISCHEMIA. T. Hashimoto, B. Itoh, C.L. Chen, T. Matsubara, K. Itoh, N, Hibi, K. Nishimura, T. Kambe, N. Sakamoto, S. Sugiyama*, 'I. Ozawa*, T. Ohki**, A. Saitoh**, K. Ohta**. 3rd Dept. of Intern. Med. and Dept. of Biomed. Chem.*, School of Med., Nagoya Univ., The Bio-Dynamics Res. Instit.**, Nagoya, Japan. (55) IS ISCHEMIA-INDUCED PH DECREASE OF DOG MYOCARDIUM RESPIRATORY OR METABOLIC ACIDOSIS? K. Ichihara, N. Haga, Y. Abiko. Department of Pharmacology, Asahikawa Medical College, Asahikawa, Japan. (56) RIGHT AND LEFT VENTRICULAR OXYGEN METABOLISM IN OPEN-CHEST DOGS. K. Takeda, T. Hyodo, Y. Abe, D. Saito, S. Haraoka, H. Nagashima. The First Department of Internal Medicine, Okayama Unviersity Medical School, Okayama, Japan. (57) HIGH GRADE HYPOXIA IN MYOCARDIAL CELL CULTURES. H. Ishida, F. Ohsuzu, H. Kohara, K. Hosono. National Defense Medical Tokorozawa, Japan. (58)
N. Aosaki, College,
ELECTRICAL ACTIVITY OF CARDIAC CELLS TRANSPLANTED INTO THE RENAL Y. Nishizono, K. CAPSULAR SPACE OF THE RAT AND EFFECTS OF ISCHFMIA. Nishi. Department of Pharmacology, Kumamoto University Medical School, Kumamoto, Japan. (59) MYOCARDIAL Tamura, N. Mori. 2nd Tokushima,
DISORDERS OF HEREDITARILY DIABETIC KK MICE. S. Miyakami, Nagase, S. Kobayashi, H. Sako, T. Kudo, K. Saito, T. Niki, Department of Internal Medicine, Tokushima University, Japan. (60) Saturday,
5 November
1983
(10:OOa.m.
ROOM B SESSION
11
to 0:lsp.m.)
Y. H.
xv
EFFECT OF LIDOCAINE, DISOPYRAMIDE AND PROCAINEAMIDE OF CARDIAC T. Shirai, K. Izumo, S. Hara, H. EXCITABILITY OF RABBITS VENTRICLES. Showa University Fujigaoka Osada, K. Harumi. Cardiovascular Division, Hospital, Yokohama, Japan. (61) CHRONIC AND ACUTE EFFECTS OF AMIODARONE ON THE RABBIT HEART MUSCLES. The 3rd Div., Kadoya, T. Konishi, T. Tamamura, S. Ikeguchi, C. Kawai. Med., Fat. of Med., Kyoto Univ., Kyoto, Japan. (62) Dep. of Int. EFFECTS OF CONTRAST MEDIA AND HYPEROSMOLALITY ON ACTION POTENTIAL OF GUINEA PIG PAPILLARY MUSCLE. M. Sumikawa, Y. Hirata, K. Shimomura. Dept. Int. Med., National Cardiovascular Center, Suita, Osaka, Japan.
M.
(6 3)
EFFECTS OF CO'+ AND DANTROLENE OF ELECTRICAL AND MECHANICAL OSCILLATIONS H. Kinoshita, S. Kawano, M. Hiraoka. IN GUINEA-PIG VENTRICULAR MUSCLES. Dept. Cardiovasc. Dis., MRI, Tokyo Medical and Dental University, Tokyo,
OF (66)
INWARD RECTIFYING PROPERTIES IN SINGLE CHANNEL K+ CURRENT OF ISOLATED GUINEA PIG MYOCARDIAL CELL. J. Taniguchi. Fat. Science, Deet , Biology, Osaka University, Osaka & Dept, Molecular Physiology, National Cardiovascular Center Research Institute, Osaka, Japan. (67) Saturday,
5 November
1983
(10:30a.m.
to 12noon)
ROOM C SESSION
12
THE EFFECTS 0~ SELECTIVE THROMBOXANE SYNTHETASE INHIBITOR (OKY-046) 0~ MYOCARDIAL INFARCT SIZE IN ANESTHETIZED DOGS. M. Moriuchi, M. Tsuji, S. Saito, Y. Tamura, Y. Ozawa, M. Hatano, I. Sakurai*. The 2nd Department
XVI
of Internal Department
Medicine, Nihon University of Pathology, Tokyo, Japan.
School (68 )
of Medicine,
*The
2nd
ELECTROPHYSIOLOGICAL ANALYSES OF THE EFFECTS OF PROSTAGLANDINS ON THE BULLFROG ATRIAL MUSCLES. M. Hachisuga, M. Goto. Department of Physiology, Faculty of Medicine, Fukuoka, Japan. (69) EXCESSIVE THROMBOXANE A2 PRODUCTION DURING EVOLUTING PROCESS IN ACUTE MYOCARDIAL INFARCTION. S. Hoshida, T. Kuzuya, M. Ohmori, M. Yamagishi, H. Matsuda, M. Tada, H. Abe. The First Dept. of Med., Osaka Univ. Sch. of Med., Osaka, Japan. (70) EFFECTS OF SELECTIVE THROMBOXANE A2 SYNTHETASE INHIBITOR (OKY-1518, 046) IN PATIENTS WITH ANGINA PECTORIS. T. Ito, M. Sikano, L.S. Chen, K. Ogawa, T. Satake. The 2nd Dep. of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan. (71) 2+ TENSION IN GLYCERINATED CARDIAC MUSCLE AT VARIOUS Mg AND MgATP CONCENTRATIONS, AND THE TRANSIENT TENSION RESPONSES TO STEP LENGTH C. Kato, T. Horikoshi, K. Yanagisawa. CHANGES. Y. Saeki, Dept. of Physiol., Tsurumi Univ. Sch. of Dent. Med., Yokohama, Japan. (72) MECHANISM OF DIRECT CARDIOSTIMULATING ACTIONS OF HYDRALAZINE. A. Sawamura, J. Azuma, H. Harada, K. Ogura, N. Awata, H. Ohta, K. Yamauchi,. S. Kishimoto. Third Department of Internal Medicine, Osaka University Medical School, Osaka, Japan. (73)