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PROSTHODONTIC REHABILITATION OF PATIENTS WITH MANDIBULAR RESECTION: AN UPDATED REVIEW AND AN ILLUSTRATIVE CASE
OOOO Volume 129, Number 1 showed a higher frequency in Asia and North America, mainly affecting men in the fifth decade of life. Conclusion: DGCT is an extremely rare lesion. Data regarding age of the Brazilian patients reported here differ with findings from cases reported elsewhere. Support: FAPEMIG
RETROSPECTIVE ANALYSES OF 300 CASES OF ODONTOGENIC KERATOCYST. ROBERTA RAYRA MARTINS CHAVES, LAUREN FRENZEL SCHUCH, KAROLINA SKARLET SILVA VIANA, WAGNER HENRIQUES DE CASTRO, RICARDO SANTIAGO GOMEZ and, RICARDO ALVES DE MESQUITA Objectives: To analyze the clinical and radiographic features of odontogenic keratocyst (OKC) from a Brazilian oral and maxillofacial pathology reference center. Study Design: Data regarding sex, ethnicity, age, time of evolution, symptoms, location, radiographic features, size, treatment, and recurrence of OKC were collected. Results: Among 37,029 oral biopsies, 1915 (5.2%) were odontogenic cyst, of which 300 (0.8%) met the criteria of OKC. Males (51.3%) of African descent (57.1%) were more prevalent. Individuals in their third decade (31.4%) were more affected. Asymptomatic lesions (79.3%) were reported by most of the patients. Radiolucent (100.0%), well-defined (27.9%), unilocular (28.4%) lesions with a mean size of 3.5 cm on the posterior mandible (48.9%) were more commonly found. Impacted teeth were associated in 30 cases. The percentage of cases surgically excised was 65.8%. Recurrence was seen in 67 patients (25.4%). Conclusions: The findings of this study were similar in many ways to previous reports. However, concerning skin color, the literature shows a greater number of cases in Caucasian individuals. Support: FAPEMIG.
PROSTHODONTIC REHABILITATION OF PATIENTS WITH MANDIBULAR RESECTION: AN UPDATED REVIEW AND AN ILLUSTRATIVE CASE. JULIANA BIANCHI SOUZA DOS PASSOS, POLIANNE ALVES MENDES NASCIMENTO, JOSE ALCIDES ALMEIDA ARRUDA, FREDERICO DOS LUCAS GUIMARAES e ABREU, RICARDO REIS GOYATA, ALVES MESQUITA and, AMALIA MORENO Objective: To review 55 literature cases of patients with a history of mandibulectomy who were rehabilitated with a maxillofacial prosthesis and to discuss details such as age, sex, histopathology, type of mandibular resection, aesthetic and functional disorders, surgical reconstruction, treatment, and follow-up period. An illustrative case of prosthetic rehabilitation after hemi-mandibulectomy is also presented. Study Design: The study was carried out in 2 steps. In the first part, an electronic search of prosthetic rehabilitation after hemi- and complete mandibulectomy was undertaken in 4 databases. In the second part, we presented a case of a patient diagnosed with oral squamous cell carcinoma (OSCC) and rehabilitated with fixed and removable prostheses. Results: The sample consisted of 37 (67%) males and 18 (33%) females, with a mean age of 44.3 years. The predominant histopathology was OSCC (52.7%). All patients who had mandibulectomy were treated with a maxillary or mandibular prosthesis. Different types of prosthetic rehabilitation were detected,
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with follow-up periods between 3 weeks and 15 years. The illustrative case was submitted to hemi-mandibulectomy and received provisional and restorative prostheses, with 2 years of follow-up care. Conclusions: Prosthetic rehabilitation was fundamental in order to stabilize occlusion, to correct deviation from the midline, and to improve masticatory efficiency in addition to aesthetic appearance. Support: FAPEMIG.
EVALUATION OF MIR-181 FAMILY MEMBERS IN ORAL CANCER. SILVIA MARIA DE CARVALHO LYRA, ANA BEATRIZ BRAGA MOLERI, FLAVIA MACHADO LIMA, ANDREA ^ REGINA SOUZA LIMA, ROMULO SPERDUTO DEZONNE, CARINA MACIEL DA SILVA BOGHOSSIAN and, CLAUDIA MARIA PEREIRA Oral cancer is the seventh most frequent type of cancer in the Brazilian population, with high invasiveness, metastasis rates, and recurrence. The main risk factors involved are tobacco consumption, alcoholism, and human papillomavirus (HPV) infection. Oral squamous cell carcinoma (OSCC) is the most frequent histologic type. Studies report miR-181 as an important biomarker for the prognosis and survival during glioblastoma multiforme pathogenesis. However, there is no evaluation of their expression in the OSCC, nor their relation with clinical-pathologic data. Objective: The aim of the present study was to evaluate miR-181 family members’ expression in patients with OSCC. Study Design: The expression of miR-181 a/b/c in 20 OSCC and 20 healthy oral mucosa samples was evaluated by quantitative PCR (qPCR). Results: Downregulation of miR-181 a and miR-181 c were observed in 30% and 35% of the samples, respectively. Overexpression of miR-181 b was present in 41% of the cases. A tendency between alcoholism and underexpression of miR-181 c was observed. Conclusions: There is a probable relation between a member of the miR-181 family and an etiologic factor associated with OSCC. However, new studies with a larger number of patients are required to determine the importance of these biomarkers on oral carcinogenesis.
IMMUNOHISTOCHEMICAL ANALYSIS OF HUMAN LEUKOCYTE ANTIGEN-DR (HLADR) IN LIP CARCINOGENESIS. EMANUENE GALDINO PIRES, LUANA SAMARA BALDUINO DE SENA, HELLEN BANDEIRA DE PONTES SANTOS, MARINA GONCALVES ¸ DO AMARAL, MANUEL ^ e NEZ, ANTONIO GORDON-N U POLLIANNA MUNIZ ALVES and, CASSIANO FRANCISCO WEEGE NONAKA Objective: To evaluate the immunoexpression of human leukocyte antigen-DR (HLA-DR) in actinic cheilitis (AC) and lower-lip squamous cell carcinomas (LLSCCs), and to correlate the findings with clinicopathologic parameters (tumor size and extent, regional lymph node metastasis, clinical stage, risk of malignant transformation for AC and histopathologic grade of malignancy for LLSCCs). Study Design: The percentage of HLA-DR positive cells in the epithelial component of 24 cases of AC and 48 LLSCCs (24 with regional nodal metastasis and 24 without
RETROSPECTIVE ANALYSES OF 300 CASES OF ODONTOGENIC KERATOCYST. ROBERTA RAYRA MARTINS CHAVES, LAUREN FRENZEL SCHUCH, KAROLINA SKARLET SILVA VIANA, WAGNER HENRIQUES DE CASTRO, RICARDO SANTIAGO GOMEZ and, RICARDO ALVES DE MESQUITA Objectives: To analyze the clinical and radiographic features of odontogenic keratocyst (OKC) from a Brazilian oral and maxillofacial pathology reference center. Study Design: Data regarding sex, ethnicity, age, time of evolution, symptoms, location, radiographic features, size, treatment, and recurrence of OKC were collected. Results: Among 37,029 oral biopsies, 1915 (5.2%) were odontogenic cyst, of which 300 (0.8%) met the criteria of OKC. Males (51.3%) of African descent (57.1%) were more prevalent. Individuals in their third decade (31.4%) were more affected. Asymptomatic lesions (79.3%) were reported by most of the patients. Radiolucent (100.0%), well-defined (27.9%), unilocular (28.4%) lesions with a mean size of 3.5 cm on the posterior mandible (48.9%) were more commonly found. Impacted teeth were associated in 30 cases. The percentage of cases surgically excised was 65.8%. Recurrence was seen in 67 patients (25.4%). Conclusions: The findings of this study were similar in many ways to previous reports. However, concerning skin color, the literature shows a greater number of cases in Caucasian individuals. Support: FAPEMIG.
PROSTHODONTIC REHABILITATION OF PATIENTS WITH MANDIBULAR RESECTION: AN UPDATED REVIEW AND AN ILLUSTRATIVE CASE. JULIANA BIANCHI SOUZA DOS PASSOS, POLIANNE ALVES MENDES NASCIMENTO, JOSE ALCIDES ALMEIDA ARRUDA, FREDERICO DOS LUCAS GUIMARAES e ABREU, RICARDO REIS GOYATA, ALVES MESQUITA and, AMALIA MORENO Objective: To review 55 literature cases of patients with a history of mandibulectomy who were rehabilitated with a maxillofacial prosthesis and to discuss details such as age, sex, histopathology, type of mandibular resection, aesthetic and functional disorders, surgical reconstruction, treatment, and follow-up period. An illustrative case of prosthetic rehabilitation after hemi-mandibulectomy is also presented. Study Design: The study was carried out in 2 steps. In the first part, an electronic search of prosthetic rehabilitation after hemi- and complete mandibulectomy was undertaken in 4 databases. In the second part, we presented a case of a patient diagnosed with oral squamous cell carcinoma (OSCC) and rehabilitated with fixed and removable prostheses. Results: The sample consisted of 37 (67%) males and 18 (33%) females, with a mean age of 44.3 years. The predominant histopathology was OSCC (52.7%). All patients who had mandibulectomy were treated with a maxillary or mandibular prosthesis. Different types of prosthetic rehabilitation were detected,
ABSTRACTS
e141
with follow-up periods between 3 weeks and 15 years. The illustrative case was submitted to hemi-mandibulectomy and received provisional and restorative prostheses, with 2 years of follow-up care. Conclusions: Prosthetic rehabilitation was fundamental in order to stabilize occlusion, to correct deviation from the midline, and to improve masticatory efficiency in addition to aesthetic appearance. Support: FAPEMIG.
EVALUATION OF MIR-181 FAMILY MEMBERS IN ORAL CANCER. SILVIA MARIA DE CARVALHO LYRA, ANA BEATRIZ BRAGA MOLERI, FLAVIA MACHADO LIMA, ANDREA ^ REGINA SOUZA LIMA, ROMULO SPERDUTO DEZONNE, CARINA MACIEL DA SILVA BOGHOSSIAN and, CLAUDIA MARIA PEREIRA Oral cancer is the seventh most frequent type of cancer in the Brazilian population, with high invasiveness, metastasis rates, and recurrence. The main risk factors involved are tobacco consumption, alcoholism, and human papillomavirus (HPV) infection. Oral squamous cell carcinoma (OSCC) is the most frequent histologic type. Studies report miR-181 as an important biomarker for the prognosis and survival during glioblastoma multiforme pathogenesis. However, there is no evaluation of their expression in the OSCC, nor their relation with clinical-pathologic data. Objective: The aim of the present study was to evaluate miR-181 family members’ expression in patients with OSCC. Study Design: The expression of miR-181 a/b/c in 20 OSCC and 20 healthy oral mucosa samples was evaluated by quantitative PCR (qPCR). Results: Downregulation of miR-181 a and miR-181 c were observed in 30% and 35% of the samples, respectively. Overexpression of miR-181 b was present in 41% of the cases. A tendency between alcoholism and underexpression of miR-181 c was observed. Conclusions: There is a probable relation between a member of the miR-181 family and an etiologic factor associated with OSCC. However, new studies with a larger number of patients are required to determine the importance of these biomarkers on oral carcinogenesis.
IMMUNOHISTOCHEMICAL ANALYSIS OF HUMAN LEUKOCYTE ANTIGEN-DR (HLADR) IN LIP CARCINOGENESIS. EMANUENE GALDINO PIRES, LUANA SAMARA BALDUINO DE SENA, HELLEN BANDEIRA DE PONTES SANTOS, MARINA GONCALVES ¸ DO AMARAL, MANUEL ^ e NEZ, ANTONIO GORDON-N U POLLIANNA MUNIZ ALVES and, CASSIANO FRANCISCO WEEGE NONAKA Objective: To evaluate the immunoexpression of human leukocyte antigen-DR (HLA-DR) in actinic cheilitis (AC) and lower-lip squamous cell carcinomas (LLSCCs), and to correlate the findings with clinicopathologic parameters (tumor size and extent, regional lymph node metastasis, clinical stage, risk of malignant transformation for AC and histopathologic grade of malignancy for LLSCCs). Study Design: The percentage of HLA-DR positive cells in the epithelial component of 24 cases of AC and 48 LLSCCs (24 with regional nodal metastasis and 24 without