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Psychosocial problem of people with epilepsy in Ulaanbaatar of Mongolia
Abstracts / Journal of the Neurological Sciences 405S (2019) 116542
Conclusions The highest satisfaction observed with primary focal HH, and the least with focal dystonia disorders. These surveys indicate that patients’ satisfaction with BTX is overall good.
doi:10.1016/j.jns.2019.10.803
WCN19-0288 Journal of the Neurological Sciences 405S (2019) 104466
23
Methods In this cross-sectional study, we enrolled 62 PD, 27 AD and 52 controls from Phramongkutklao Neurology clinic. Odor identification kit with 8 familiar-to-Thai odors was used to evaluate odor scores. To assess disease severity, Thai Mental State Examination, Functional Assessment Staging Test, The Lawton Instrumental Activities of Daily Living Scale, Thai Neuropsychiatric Inventory Questionnaire were applied in AD patients. While PD patients were evaluated using modified Hoehh & Yahr staging and Unified Parkinson’s Disease Rating Scale part I and II. Kruskal-Wallis test as a rank-based nonparametric test was performed to determine difference of odor scores between groups.
Agenesis of the corpus callosum: A rare association with EhlersDanlos syndrome
Results A total 141 volunteers were included in the analysis. PD and AD patients had significantly lower scores compared with controls. The analysis also revealed significantly lower scores in PD compared with controls between 51-60 years of age. There was no correlation between the scores and disease severity in both disease groups.
M. Afrakhteh, F. Haji-akhoundi, M. Almasi-dooghaee, Z. Mirzaasgari Iran university of medical science, Firouzgar hospital-neurology ward, Tehran, Iran
Conclusions Phramongkutklao odor identification kit is applicable as a supplementary tool to diagnose patients with PD and AD.
Ehlers-Danlos syndrome (EDS) is a rare congenital disorder of connective tissues which involves skin and musculoscleletalsystem. There are also some reports for involvement of central and peripheral nervous system. We want to present a very rare coassociation of EDS, spondylolisthesis and Agenesis of the corpus callosum in an Iranian lady.
doi:10.1016/j.jns.2019.10.805
Poster Session 2
Keywords: Ehlers-Danlos syndrome, Spondylolisthesis, Agenesis of the corpus callosum
doi:10.1016/j.jns.2019.10.804
WCN19-0311 Journal of the Neurological Sciences 405S (2019) 104467 Poster Session 2 Odor identification kit as a diagnostic tool for patients with Parkinson's and Alzheimer's disease K. Paurika, P. Sithinamsuwan, N. Namphol, L. Cheewakriengkrai Phramongkutklao Hospital, Neurology division Department of Medicine, Bkk, Thailand Introduction Olfactory dysfunction has been described in preclinical stages of certain neurodegenerative diseases. The association has been described in Alzheimer’s disease (AD) and Parkinson’s disease (PD). However, there are no standard methods in Thailand to study the olfactory dysfunction among these groups of patients. Objectives Primary: to verify Phramongkutklao odor identification kit as an accurate tool to identify patients with early and established AD and PD. Secondary : to find correlations between degree of olfactory dysfunction with patient characteristics and severity of the two diseases.
WCN19-0313 Journal of the Neurological Sciences 405S (2019) 104468 Poster Session 2 Psychosocial problem of people with epilepsy in Ulaanbaatar of Mongolia B. Dagvadorja, T. Avirmedb a The Central Hospital of the Khuvsgul Province, Neurology, Khuvsgul, Mongolia b Mongolian National University of Medical Sciences, Neurology, Ulaanbaatar, Mongolia Background Epilepsy is a common neurological disease, which need to health care and public health service topicality that is a very important for people with epilepsy (PWE). Purpose To investigate psychosocial problem of the people with epilepsy. Method 77 patients were included in our study. In order to identify psychosocial problems we used the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI) and a ten-item measure of felt stigma for this cross-sectional study. Result There were 46.8% female, 44.2% were married, 75.3% unemployment. The frequencies of anxiety symptoms in PWE were 31.2% very anxiety, 32.5% anxiety and 36.4% not anxiety, the rates of depressive symptoms in PWE were 18.2% very depressed, 19.5% depressed and 62.3% not depressed, respectively. All of the 62.3% PWE felt stigma. Considering the age, psychological problem, some of the variables of
24
Abstracts / Journal of the Neurological Sciences 405S (2019) 116542
the participants, the age of the people with epilepsy was associated with depression and the stigma scores, negatively. (r= -0.2 p=0.05; r = -0.2 p=0.05). There are relationships between stigma and anxiety, depression, social-interaction of the attitude scores in PWE. (r= 0.5 p= 0.01; r= 0.5 p= 0.01; r=0.4 p= 0.01). Whereas that the correlation statistic did not indicate a relationship between the duration of the epilepsy and anxiety, depression, stigma and socialinteraction’s scores
WCN19-0332
Conclusion This reveals that it has positive relationship with social-interaction and attitude. Frequency of epileptic seizures induces the anxiety and depression of the people with epilepsy and thus worsens their stigmatization.
A. Diwan DR VP Medical College- Nashik, Pediatrics, Nashik, India
Key words: Epilepsy, Anxiety, Depression
doi:10.1016/j.jns.2019.10.806
WCN19-0316 Journal of the Neurological Sciences 405S (2019) 104469 Poster Session 2 Pachymeningitis as a presenting manifestation of Wegener`s granulomatosis D. Hota West Bengal University of Health Science, Department of Neurology, Burdwan, India
Journal of the Neurological Sciences 405S (2019) 104470 Poster Session 2 Awake epilepsy surgery
Epilepsy surgery performed as curative or palliative to control epilepsy by resecting the epileptogenic region while preserving function. In some patients the epileptogenic foci can be involving or very next to eloquent cortex. In those patients, Epilepsy surgery becomes challenging and awake surgery is implemented. We present our experience of 2 cases, who underwent lesionectomy for epilepsy with awake craniotomy. Both cases had FCD (focal cortical dysplsia in left frontal cortex, near motor strip and Broca’s speech area. Presurgical work up and functional MRI were performed. Intraoperatively under awake conditions, patients were asked to move Rt hand or speak continuously. Electrocorticograms (ECoGs) were recorded in both cases before and after the excision of lesion (FCD). EcoG information did not change surgical strategy. Postoperatively, both patients did not have any neurodeficit. 1st patient 18 mths after surgery, is still seizure free. 2nd patient is just 6mths post surgery and without any seizures. Thus, for patients with epileptogenic foci in and around functionally eloquent areas, awake surgery allows safe and maximal resection of the epileptic foci; intraoperative ECoG evaluation did not changed much of our surgical strategy. Awake craniotomy for epilepsy leads to improved seizure control and functional outcomes. doi:10.1016/j.jns.2019.10.808
An 18yr old married female presented with 3 month history of intermittent headache mostly on right side of hemicranium associated with on & off fever along with nausea and vomiting. The pain in right side of head is radiating into right inner canthus of eye along with right side of neck. Non diabetic but past history of multiple episodes of epistaxis in the childhood period along with chest infections which resulted in multiple local doctor consultation with permanent cure. She has normal menstrual cycle. On examination she has mild pallor. On Cranial nerve examination there is restriction of lateral rectus on right gaze but rest of movement is normal with pupil normally reacting to light. motor & sensory system normal. There is mild neck stiffness with kernig`s negative. CSF study shows no pleocystosis with normal protein and sugar showing noninfective nature. As there is history of multiple episode of epistaxis along with that she herself again developed 2-3 episodes of epistaxis during hospitalisation with normal PT-INR. CT Scan of PNS showed hyperintensity of maxillary sinus margin with HRCT of Thorax showed granulomatous interstitial lung diseases. So we suspected Wegener`s granulomatosis (GPA) and sent ANCA profile which came out to be C-ANCA positive. On MRI of Brain & Orbit it showed patchy meningitis at and along the lateral wall of right cavernous sinus extending into right temporal bone. Finally we concluded that constrast enhancement along cavernous sinus is non-infective with inflammatory lesion most probably due to Granulomatosis with polyangitis doi:10.1016/j.jns.2019.10.807
WCN19-0342 Journal of the Neurological Sciences 405S (2019) 104471 Poster Session 2 Comparison of zonisamide with non-levodopa, anti-Parkinson’s disease drugs in the incidence of Parkinson’s disease-relevant symptoms M. Nomotoa, H. Iwakia, M. Tagawab, K. Iwasakic a Ehime University Graduate School of Medicine, Department of Neurology and Clinical Pharmacology, Ehime, Japan b Sumitomo Dainippon Pharma Co. Ltd., Medical Affairs, Tokyo, Japan c Milliman Inc., Japan Healthcare Practice and Data Analytics, Tokyo, Japan Backgrond and objective Patients with Parkinson’s disease (PD) experience various symptoms, both from the disease progression itself and the medication. Few large-scale studies have investigated the associations between zonisamide and these symptoms. This study compared zonisamide and other anti-PD drugs by analyzing their associations with the incidence of PD-relevant symptoms.
Conclusions The highest satisfaction observed with primary focal HH, and the least with focal dystonia disorders. These surveys indicate that patients’ satisfaction with BTX is overall good.
doi:10.1016/j.jns.2019.10.803
WCN19-0288 Journal of the Neurological Sciences 405S (2019) 104466
23
Methods In this cross-sectional study, we enrolled 62 PD, 27 AD and 52 controls from Phramongkutklao Neurology clinic. Odor identification kit with 8 familiar-to-Thai odors was used to evaluate odor scores. To assess disease severity, Thai Mental State Examination, Functional Assessment Staging Test, The Lawton Instrumental Activities of Daily Living Scale, Thai Neuropsychiatric Inventory Questionnaire were applied in AD patients. While PD patients were evaluated using modified Hoehh & Yahr staging and Unified Parkinson’s Disease Rating Scale part I and II. Kruskal-Wallis test as a rank-based nonparametric test was performed to determine difference of odor scores between groups.
Agenesis of the corpus callosum: A rare association with EhlersDanlos syndrome
Results A total 141 volunteers were included in the analysis. PD and AD patients had significantly lower scores compared with controls. The analysis also revealed significantly lower scores in PD compared with controls between 51-60 years of age. There was no correlation between the scores and disease severity in both disease groups.
M. Afrakhteh, F. Haji-akhoundi, M. Almasi-dooghaee, Z. Mirzaasgari Iran university of medical science, Firouzgar hospital-neurology ward, Tehran, Iran
Conclusions Phramongkutklao odor identification kit is applicable as a supplementary tool to diagnose patients with PD and AD.
Ehlers-Danlos syndrome (EDS) is a rare congenital disorder of connective tissues which involves skin and musculoscleletalsystem. There are also some reports for involvement of central and peripheral nervous system. We want to present a very rare coassociation of EDS, spondylolisthesis and Agenesis of the corpus callosum in an Iranian lady.
doi:10.1016/j.jns.2019.10.805
Poster Session 2
Keywords: Ehlers-Danlos syndrome, Spondylolisthesis, Agenesis of the corpus callosum
doi:10.1016/j.jns.2019.10.804
WCN19-0311 Journal of the Neurological Sciences 405S (2019) 104467 Poster Session 2 Odor identification kit as a diagnostic tool for patients with Parkinson's and Alzheimer's disease K. Paurika, P. Sithinamsuwan, N. Namphol, L. Cheewakriengkrai Phramongkutklao Hospital, Neurology division Department of Medicine, Bkk, Thailand Introduction Olfactory dysfunction has been described in preclinical stages of certain neurodegenerative diseases. The association has been described in Alzheimer’s disease (AD) and Parkinson’s disease (PD). However, there are no standard methods in Thailand to study the olfactory dysfunction among these groups of patients. Objectives Primary: to verify Phramongkutklao odor identification kit as an accurate tool to identify patients with early and established AD and PD. Secondary : to find correlations between degree of olfactory dysfunction with patient characteristics and severity of the two diseases.
WCN19-0313 Journal of the Neurological Sciences 405S (2019) 104468 Poster Session 2 Psychosocial problem of people with epilepsy in Ulaanbaatar of Mongolia B. Dagvadorja, T. Avirmedb a The Central Hospital of the Khuvsgul Province, Neurology, Khuvsgul, Mongolia b Mongolian National University of Medical Sciences, Neurology, Ulaanbaatar, Mongolia Background Epilepsy is a common neurological disease, which need to health care and public health service topicality that is a very important for people with epilepsy (PWE). Purpose To investigate psychosocial problem of the people with epilepsy. Method 77 patients were included in our study. In order to identify psychosocial problems we used the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI) and a ten-item measure of felt stigma for this cross-sectional study. Result There were 46.8% female, 44.2% were married, 75.3% unemployment. The frequencies of anxiety symptoms in PWE were 31.2% very anxiety, 32.5% anxiety and 36.4% not anxiety, the rates of depressive symptoms in PWE were 18.2% very depressed, 19.5% depressed and 62.3% not depressed, respectively. All of the 62.3% PWE felt stigma. Considering the age, psychological problem, some of the variables of
24
Abstracts / Journal of the Neurological Sciences 405S (2019) 116542
the participants, the age of the people with epilepsy was associated with depression and the stigma scores, negatively. (r= -0.2 p=0.05; r = -0.2 p=0.05). There are relationships between stigma and anxiety, depression, social-interaction of the attitude scores in PWE. (r= 0.5 p= 0.01; r= 0.5 p= 0.01; r=0.4 p= 0.01). Whereas that the correlation statistic did not indicate a relationship between the duration of the epilepsy and anxiety, depression, stigma and socialinteraction’s scores
WCN19-0332
Conclusion This reveals that it has positive relationship with social-interaction and attitude. Frequency of epileptic seizures induces the anxiety and depression of the people with epilepsy and thus worsens their stigmatization.
A. Diwan DR VP Medical College- Nashik, Pediatrics, Nashik, India
Key words: Epilepsy, Anxiety, Depression
doi:10.1016/j.jns.2019.10.806
WCN19-0316 Journal of the Neurological Sciences 405S (2019) 104469 Poster Session 2 Pachymeningitis as a presenting manifestation of Wegener`s granulomatosis D. Hota West Bengal University of Health Science, Department of Neurology, Burdwan, India
Journal of the Neurological Sciences 405S (2019) 104470 Poster Session 2 Awake epilepsy surgery
Epilepsy surgery performed as curative or palliative to control epilepsy by resecting the epileptogenic region while preserving function. In some patients the epileptogenic foci can be involving or very next to eloquent cortex. In those patients, Epilepsy surgery becomes challenging and awake surgery is implemented. We present our experience of 2 cases, who underwent lesionectomy for epilepsy with awake craniotomy. Both cases had FCD (focal cortical dysplsia in left frontal cortex, near motor strip and Broca’s speech area. Presurgical work up and functional MRI were performed. Intraoperatively under awake conditions, patients were asked to move Rt hand or speak continuously. Electrocorticograms (ECoGs) were recorded in both cases before and after the excision of lesion (FCD). EcoG information did not change surgical strategy. Postoperatively, both patients did not have any neurodeficit. 1st patient 18 mths after surgery, is still seizure free. 2nd patient is just 6mths post surgery and without any seizures. Thus, for patients with epileptogenic foci in and around functionally eloquent areas, awake surgery allows safe and maximal resection of the epileptic foci; intraoperative ECoG evaluation did not changed much of our surgical strategy. Awake craniotomy for epilepsy leads to improved seizure control and functional outcomes. doi:10.1016/j.jns.2019.10.808
An 18yr old married female presented with 3 month history of intermittent headache mostly on right side of hemicranium associated with on & off fever along with nausea and vomiting. The pain in right side of head is radiating into right inner canthus of eye along with right side of neck. Non diabetic but past history of multiple episodes of epistaxis in the childhood period along with chest infections which resulted in multiple local doctor consultation with permanent cure. She has normal menstrual cycle. On examination she has mild pallor. On Cranial nerve examination there is restriction of lateral rectus on right gaze but rest of movement is normal with pupil normally reacting to light. motor & sensory system normal. There is mild neck stiffness with kernig`s negative. CSF study shows no pleocystosis with normal protein and sugar showing noninfective nature. As there is history of multiple episode of epistaxis along with that she herself again developed 2-3 episodes of epistaxis during hospitalisation with normal PT-INR. CT Scan of PNS showed hyperintensity of maxillary sinus margin with HRCT of Thorax showed granulomatous interstitial lung diseases. So we suspected Wegener`s granulomatosis (GPA) and sent ANCA profile which came out to be C-ANCA positive. On MRI of Brain & Orbit it showed patchy meningitis at and along the lateral wall of right cavernous sinus extending into right temporal bone. Finally we concluded that constrast enhancement along cavernous sinus is non-infective with inflammatory lesion most probably due to Granulomatosis with polyangitis doi:10.1016/j.jns.2019.10.807
WCN19-0342 Journal of the Neurological Sciences 405S (2019) 104471 Poster Session 2 Comparison of zonisamide with non-levodopa, anti-Parkinson’s disease drugs in the incidence of Parkinson’s disease-relevant symptoms M. Nomotoa, H. Iwakia, M. Tagawab, K. Iwasakic a Ehime University Graduate School of Medicine, Department of Neurology and Clinical Pharmacology, Ehime, Japan b Sumitomo Dainippon Pharma Co. Ltd., Medical Affairs, Tokyo, Japan c Milliman Inc., Japan Healthcare Practice and Data Analytics, Tokyo, Japan Backgrond and objective Patients with Parkinson’s disease (PD) experience various symptoms, both from the disease progression itself and the medication. Few large-scale studies have investigated the associations between zonisamide and these symptoms. This study compared zonisamide and other anti-PD drugs by analyzing their associations with the incidence of PD-relevant symptoms.