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Re: Gender-Dependent Cancer-Specific Survival Following Radical Cystectomy
BLADDER, PENIS AND URETHRA CANCER, AND BASIC PRINCIPLES OF ONCOLOGY
seeding was identified, and no residual disease or local recurrence was reported. It appears that with experience complex cystic lesions can be treated with more confidence. Jeffrey A. Cadeddu, MD
Urological Oncology: Bladder, Penis and Urethra Cancer, and Basic Principles of Oncology Re: Gender-Dependent Cancer-Specific Survival Following Radical Cystectomy M. May, C. Stief, S. Brookman-May, W. Otto, C. Gilfrich, J. Roigas, M. Zacharias, €dter and M. Burger W. F. Wieland, H. M. Fritsche, F. Hofsta Department of Urology, St. Elisabeth Hospital, Straubing, Germany World J Urol 2012; 30: 707e713.
Abstract available at http://jurology.com/ Editorial Comment: Women had decreased cancer specific survival if treated from 1992 to 1999 but not from 1999 to 2007, after controlling for other prognostic factors. This result is probably related to better diagnosis in women with hematuria and more aggressive treatment. David P. Wood, MD
Re: Lymph Node Density for Patient Counselling about Prognosis and for Designing Clinical Trials of Adjuvant Therapies after Radical Cystectomy E. K. Lee, H. W. Herr, R. J. Dickstein, W. Kassouf, M. F. Munsell, H. B. Grossman, C. P. Dinney and A. M. Kamat Departments of Urology and Biostatistics, University of Texas M.D. Anderson Cancer Center, Houston, Texas BJU Int 2012; 110: E590eE595.
Abstract available at http://jurology.com/ Editorial Comment: It makes sense that the more metastatic lymph nodes found, the worse the prognosis. This article helps to categorize the lymph node density, although the range from low to high density groups is tight, as seen in the 5-year disease-free survival of 61.9% in patients with lymph node density less than 10% vs 19.2% in those with lymph node density greater than 15%. David P. Wood, MD
Re: Anatomic Basis for Lymph Node Counts as Measure of Lymph Node Dissection Extent: A Cadaveric Study J. D. Davies, C. M. Simons, N. Ruhotina, D. A. Barocas, P. E. Clark and T. M. Morgan Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee Urology 2013; 81: 358e363.
Abstract available at http://jurology.com/
57
DIAGNOSTIC UROLOGY, URINARY DIVERSION AND PERIOPERATIVE CARE
58
Editorial Comment: The optimal extent of lymph node dissection in patients with muscle invasive bladder cancer is unclear and is the subject of an ongoing SWOG (Southwest Oncology Group) trial. This study suggests that the number of lymph nodes retrieved from anatomical dissection is highly variable and might not be a surrogate for an adequate dissection. David P. Wood, MD
Diagnostic Urology, Urinary Diversion and Perioperative Care Re: Parenteral Nutrition Does Not Improve Postoperative Recovery from Radical Cystectomy: Results of a Prospective Randomised Trial €user, P. Zehnder, G. N. Thalmann, M. Huwyler, B. Roth, F. D. Birkha F. C. Burkhard and U. E. Studer Department of Urology, University of Bern, Bern, Switzerland Eur Urol 2013; 63: 475e482.
Abstract available at http://jurology.com/ Editorial Comment: The authors conducted a prospective randomized study of 157 consecutive patients undergoing cystectomy to determine whether total parenteral nutrition can affect complications and outcomes in these patients, who are usually in a catabolic state postoperatively. The results did not display any improvement, but rather a greater incidence of postoperative complications and infections, and much higher costs. Richard K. Babayan, MD
Benign Prostatic Hyperplasia Re: Benign Prostatic Hyperplasia is a Significant Risk Factor for Bladder Cancer in Diabetic Patients: A Population-Based Cohort Study Using the National Health Insurance in Taiwan C. H. Tseng Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan BMC Cancer 2013; 13: 7.
Abstract available at http://jurology.com/ Editorial Comment: The epidemic of obesity and its concomitant effects on various disease processes have been well described. Within urology a number of conditions have been associated with obesity, including late onset hypogonadism, overactive bladder and prostatic enlargement. Associated with obesity are components of the metabolic syndrome, most notably diabetes. It has been estimated that the global incidence of diabetes will increase from about 170 million in 2000 to 366 million by the year 2030, most of which will be seen in Asian countries. More recently it has been demonstrated that there is an increased risk of bladder cancer in patients with type 2 diabetes. Moreover, agents such as pioglitazone, a prescription drug of the class thiazolidinedione with hypoglycemic action to treat
seeding was identified, and no residual disease or local recurrence was reported. It appears that with experience complex cystic lesions can be treated with more confidence. Jeffrey A. Cadeddu, MD
Urological Oncology: Bladder, Penis and Urethra Cancer, and Basic Principles of Oncology Re: Gender-Dependent Cancer-Specific Survival Following Radical Cystectomy M. May, C. Stief, S. Brookman-May, W. Otto, C. Gilfrich, J. Roigas, M. Zacharias, €dter and M. Burger W. F. Wieland, H. M. Fritsche, F. Hofsta Department of Urology, St. Elisabeth Hospital, Straubing, Germany World J Urol 2012; 30: 707e713.
Abstract available at http://jurology.com/ Editorial Comment: Women had decreased cancer specific survival if treated from 1992 to 1999 but not from 1999 to 2007, after controlling for other prognostic factors. This result is probably related to better diagnosis in women with hematuria and more aggressive treatment. David P. Wood, MD
Re: Lymph Node Density for Patient Counselling about Prognosis and for Designing Clinical Trials of Adjuvant Therapies after Radical Cystectomy E. K. Lee, H. W. Herr, R. J. Dickstein, W. Kassouf, M. F. Munsell, H. B. Grossman, C. P. Dinney and A. M. Kamat Departments of Urology and Biostatistics, University of Texas M.D. Anderson Cancer Center, Houston, Texas BJU Int 2012; 110: E590eE595.
Abstract available at http://jurology.com/ Editorial Comment: It makes sense that the more metastatic lymph nodes found, the worse the prognosis. This article helps to categorize the lymph node density, although the range from low to high density groups is tight, as seen in the 5-year disease-free survival of 61.9% in patients with lymph node density less than 10% vs 19.2% in those with lymph node density greater than 15%. David P. Wood, MD
Re: Anatomic Basis for Lymph Node Counts as Measure of Lymph Node Dissection Extent: A Cadaveric Study J. D. Davies, C. M. Simons, N. Ruhotina, D. A. Barocas, P. E. Clark and T. M. Morgan Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee Urology 2013; 81: 358e363.
Abstract available at http://jurology.com/
57
DIAGNOSTIC UROLOGY, URINARY DIVERSION AND PERIOPERATIVE CARE
58
Editorial Comment: The optimal extent of lymph node dissection in patients with muscle invasive bladder cancer is unclear and is the subject of an ongoing SWOG (Southwest Oncology Group) trial. This study suggests that the number of lymph nodes retrieved from anatomical dissection is highly variable and might not be a surrogate for an adequate dissection. David P. Wood, MD
Diagnostic Urology, Urinary Diversion and Perioperative Care Re: Parenteral Nutrition Does Not Improve Postoperative Recovery from Radical Cystectomy: Results of a Prospective Randomised Trial €user, P. Zehnder, G. N. Thalmann, M. Huwyler, B. Roth, F. D. Birkha F. C. Burkhard and U. E. Studer Department of Urology, University of Bern, Bern, Switzerland Eur Urol 2013; 63: 475e482.
Abstract available at http://jurology.com/ Editorial Comment: The authors conducted a prospective randomized study of 157 consecutive patients undergoing cystectomy to determine whether total parenteral nutrition can affect complications and outcomes in these patients, who are usually in a catabolic state postoperatively. The results did not display any improvement, but rather a greater incidence of postoperative complications and infections, and much higher costs. Richard K. Babayan, MD
Benign Prostatic Hyperplasia Re: Benign Prostatic Hyperplasia is a Significant Risk Factor for Bladder Cancer in Diabetic Patients: A Population-Based Cohort Study Using the National Health Insurance in Taiwan C. H. Tseng Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan BMC Cancer 2013; 13: 7.
Abstract available at http://jurology.com/ Editorial Comment: The epidemic of obesity and its concomitant effects on various disease processes have been well described. Within urology a number of conditions have been associated with obesity, including late onset hypogonadism, overactive bladder and prostatic enlargement. Associated with obesity are components of the metabolic syndrome, most notably diabetes. It has been estimated that the global incidence of diabetes will increase from about 170 million in 2000 to 366 million by the year 2030, most of which will be seen in Asian countries. More recently it has been demonstrated that there is an increased risk of bladder cancer in patients with type 2 diabetes. Moreover, agents such as pioglitazone, a prescription drug of the class thiazolidinedione with hypoglycemic action to treat