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Re: Klotho Gene Polymorphism of rs3752472 is Associated with the Risk of Urinary Calculi in the Population of Han Nationality in Eastern China
Urological Survey Urolithiasis/Endourology Re: Role of Proximal Tubule in the Hypocalciuric Response to Thiazide of Patients with Idiopathic Hypercalciuria K. J. Bergsland, E. M. Worcester and F. L. Coe Section of Nephrology, University of Chicago, Chicago, Illinois Am J Physiol Renal Physiol 2013; 305: F592eF599.
Abstract available at http://jurology.com/ Editorial Comment: The authors performed careful metabolic studies in patients with idiopathic hypercalciuria to determine the mechanisms behind the hypocalciuric action of chlorthalidone. They found that this action is most likely due to increased proximal tubular calcium and sodium reabsorption, resulting in reduced delivery to the distal nephron. They also found a decrease in urine pH. Both of these factors could theoretically reduce Randall plaque formation and perhaps attenuate stone activity. Dean G. Assimos, MD
Suggested Reading Ettinger B, Citron JT, Livermore B et al: Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. J Urol 1988; 139: 679.
Re: Klotho Gene Polymorphism of rs3752472 is Associated with the Risk of Urinary Calculi in the Population of Han Nationality in Eastern China C. Xu, R. J. Song, J. Yang, B. Jiang, X. L. Wang, W. Wu and W. Zhang State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China Gene 2013; 526: 494e497.
Abstract available at http://jurology.com/ Editorial Comment: Kidney stone formation may be linked to oxidative stress. Klotho is considered an antiaging molecule that is also involved in calcium and phosphate transport in the kidney. Some have hypothesized that it is an antioxidant. Dean G. Assimos, MD
Suggested Reading Khan SR: Reactive oxygen species as the molecular modulators of calcium oxalate kidney stone formation: evidence from clinical and experimental investigations. J Urol 2013; 189: 803.
0022-5347/14/1911-0097/0 THE JOURNAL OF UROLOGY® © 2014 by AMERICAN UROLOGICAL ASSOCIATION EDUCATION
AND
RESEARCH, INC.
http://dx.doi.org/10.1016/j.juro.2013.10.002 Vol. 191, 97-99, January 2014 Printed in U.S.A.
www.jurology.com
j
97
Abstract available at http://jurology.com/ Editorial Comment: The authors performed careful metabolic studies in patients with idiopathic hypercalciuria to determine the mechanisms behind the hypocalciuric action of chlorthalidone. They found that this action is most likely due to increased proximal tubular calcium and sodium reabsorption, resulting in reduced delivery to the distal nephron. They also found a decrease in urine pH. Both of these factors could theoretically reduce Randall plaque formation and perhaps attenuate stone activity. Dean G. Assimos, MD
Suggested Reading Ettinger B, Citron JT, Livermore B et al: Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. J Urol 1988; 139: 679.
Re: Klotho Gene Polymorphism of rs3752472 is Associated with the Risk of Urinary Calculi in the Population of Han Nationality in Eastern China C. Xu, R. J. Song, J. Yang, B. Jiang, X. L. Wang, W. Wu and W. Zhang State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China Gene 2013; 526: 494e497.
Abstract available at http://jurology.com/ Editorial Comment: Kidney stone formation may be linked to oxidative stress. Klotho is considered an antiaging molecule that is also involved in calcium and phosphate transport in the kidney. Some have hypothesized that it is an antioxidant. Dean G. Assimos, MD
Suggested Reading Khan SR: Reactive oxygen species as the molecular modulators of calcium oxalate kidney stone formation: evidence from clinical and experimental investigations. J Urol 2013; 189: 803.
0022-5347/14/1911-0097/0 THE JOURNAL OF UROLOGY® © 2014 by AMERICAN UROLOGICAL ASSOCIATION EDUCATION
AND
RESEARCH, INC.
http://dx.doi.org/10.1016/j.juro.2013.10.002 Vol. 191, 97-99, January 2014 Printed in U.S.A.
www.jurology.com
j
97