Recurrence and mortality of bladder cancers across age groups

3rd EAU Baltic Meeting, 27-28 May 2016, Tallinn, Estonia

63 Recurrence and mortality of bladder cancers across age groups Kannan S.1, Bhuvanagiri A.1, Kelleher J.F.1, Kowalski P.M.1, Butu D.1, Alexandrou K.1, Ahiaku E.K.N.1, Breeze J.2, Hussain M.Y.2 1 Gwynedd Hospital North West Wales NHS Trust, Dept. of Urology, Bangor, United Kingdom, 2Bangor University, Dept. of Statistics, Bangor, United Kingdom

INTRODUCTION & OBJECTIVES: We compared histological grading and staging, recurrence and mortality of transitional cell carcinoma (TCC) of the bladder across age groups (5 th - 8th decade). MATERIAL & METHODS: Retrospective analysis of patients with TCC between 2003 and 2015 in North Wales Hospital. 593 patients were diagnosed with TCC (448 Male = 76%, Mean Age = 72.1 years; range = 50-89). RESULTS: Histology showed G1 (N = 287, 48%), G2 (N = 183, 24%), and G3 (N = 123, 21%); Non-invasive (CIS/PTA/PT1, N = 451, 76%), and Invasive (PT2, N = 142, 24%). Neither histological grading, staging, nor recurrence rate were significant across age groups respectively (p = 0.63, p = 0.39, p = 0.35). Forty five percent (N = 87) of patients died in the group with recurrences; this was only 38% (N = 152) in those without recurrences. In those who had recurrences, we did not see any change in mortality rate across the different age groups (p = 0.71). However, in patients without recurrences, we saw a marginal increase in the mortality in over 60’s compared to the 50-59 group ([p = 0.06], 50-59 (N = 5, 17%), 60-69 (N = 42, 36%), 70-79 (N = 69, 43%), 80-89 (N = 36, 40%).

CONCLUSIONS: Our study confirms that there is no statistically significant difference in the histological grading, staging and recurrence rate across age groups (50-89). Mortality rates did not differ across the age groups with TCC recurrences, but did differ in those without recurrences. Eur Urol Suppl 2016; 15(5): e1230