- Email: [email protected]
RELATIONSHIP BETWEEN THE EXCESS OF EEG THETA ACTIVITY AND COGNITIVE PERFORMANCE IN HEALTHY ELDERLY SUBJECTS
Poster Presentations: P4 California, United States; 3University of California Davis, Sacramento, California, United States; 4Memory Clinic, UCSF, San Francisco, California, United States. Contact e-mail: [email protected] Background: A significant obstacle to developing effective treatments for Alzheimer’s disease (AD) is the cost of clinical trials. Valid internet-based neuropsychological tests may reduce the costs to longitudinally assess cognitively normal subjects who are at risk for cognitive decline and to recruit these subjects into AD prevention trials. Memory Match (LMM) is an online working memory game developed by Lumos Labs. Although the validity of LMM scores as measures of working memory has not yet been evaluated, longitudinal trends in LMM scores may indicate declining performance due to aging or disease. Methods: LMM learning rates, forgetting rates, and changes in the learning rates over time can be estimated before subjects are enrolled in randomized studies and used to predict decline, thus increasing statistical power, reducing sample sizes, and lowering costs. With data provided by Lumos Labs, the effects of age and time on learning and forgetting rates were estimated with a mixed effects linear regression model. 2,212 Lumosity users (ages, 40 - 79) played forty LMM game sessions following ten run-in sessions for > 1 year. Sample sizes were calculated for 80% power to detect slowing the rate of decline in the learning rate by 25% in 1 year trials for subjects selected from the lowest quartile of learning rate change estimates (decliners). Results: There were significant effects of age on lower initial LMM scores (b ¼ -.39, P <.0001), lower initial learning rates (b ¼ -.0031, P <.0001) and greater declines in learning rates over time (b ¼ -8.00E-06, P < .001). Sample sizes as small as 136 subjects/arm were estimated for 1year trials using subjects in the lower quartile of learning rate decline. Conclusions: The data suggest that declining learning rates are associated with older ages and that recruiting subjects in the lower quartile of learning rate decline significantly increases the statistical power to detect a treatment effect in clinical trials. As such, our data support the potential use of online memory games to identify subjects at risk for cognitive decline with smaller sample sizes and lower cost than traditional recruitment methods. P4-319
APATHY MAY LEAD TO DEMENTIA IN PATIENTS WITH PARKINSON’S DISEASE
Annalena Venneri, Hamad Alzahrani, University of Sheffield, Sheffield, United Kingdom. Contact e-mail: [email protected] Background: Apathy refers to a combination of behavioural, emotional and cognitive features that lead to reduced interest and participation in daily life activities. Apathy is considered one of the most common neuropsychiatric symptoms in Parkinson’s Disease (PD). The prevalence of apathy in PD is approximately 40%. Few studies have investigated the cognitive and neuroanatomical correlates of apathy in PD. From apathy studies in Alzheimer’s disease and other neurological disorders we expected to find deficits in frontal regions and in cognitive functions associated with frontal and temporal structures. Methods: Forty PD patients in the early stages of the disease (18 with apathy and 22 without apathy) underwent extensive neuropsychological screening, neuropsychiatric assessment using the Neuropsychiatric Inventory, structural MRI scanning and neurological examination. A voxel-based multiple regression analysis was used to measure negative correlation between grey matter volumes and apathy scores. Results: Higher apathy scores correlated with lower grey matter volume in several brain areas including the left insula, left inferior frontal gyrus, left middle frontal gyrus, left medial frontal gyrus, right anterior cingulate and the left superior temporal gyrus. Patients with apathy had lower scores in all cognitive tests. However, significant impairments were found in tests assessing executive functions (Letter Fluency Test and Stroop Test) and a trend-level significant difference was observed in memory tests (Rey 15-word Memory Test and Category Fluency Test) in patients with apathy when compared with patients without apathy. Conclusions: Apathy was associated with greater levels of atrophy in the frontal cortex, temporal cortex and anterior cingulate as well as overall lower level of cognitive performance, particularly in executive function and
P903
memory skills. These findings are in line with results from studies of other neurological conditions. For instance, a similar pattern of executive dysfunction has been reported in apathetic patients with PD with dementia and apathetic patients with Alzheimer disease. Apathy appears to be a risk factor for cognitive impairments in PD and might be a useful clinical indicator of dementia risk in PD. P4-320
NEUROPSYCHOLOGICAL ASSESSMENT OF ADULTS WITH DOWN SYNDROME USING THE CAMCOG-DS: A LONGITUDINAL COHORT STUDY
Bessy Benejam1, Laura Videla2, Susana Fernandez2, Maria CarmonaIragui3, Sebastian Videla2, Juan Fortea4, 1Catalan Down Syndrome Foundation, Barcelona, Spain; 2Catalan Down Syndrome Foundation, Barcelona, Spain; 3Biomedical Research Institute Sant Pau, Barcelona, Spain; 4Catalan Down Syndrome Foundation, Barcelona, Spain. Contact e-mail: [email protected] Background: Dementia caused by Alzheimer’s disease (AD) commonly affects the adult population with Down’s syndrome (DS). However, AD diagnosis represents a diagnostic challenge due to the intellectual disability associated with DS and to a lack of appropriate instruments. Methods: Prospective longitudinal 3 year cohort study. Forty-four healthy DS were recruited from the Down Medical Centre. We included only subjects with mild or moderate intellectual disability (ID) (DSM-IV and ICD-10 criteria). Subjects with cognitive and/or functional decline at baseline were excluded. Subjects underwent annual neuropsychological assessments using CAMCOG-DS. An evaluation for progression to AD was performed blinded to CAMCOG-DS scores. Results: Mean age at baseline was 38.8 years (SD 10.14). Twenty-seven patients were males (61.4%). Eighteen patients had mild ID (40.9%). CAMCOG-DS scores at baseline were related to severity of ID, but were not related to gender (p ¼ 0.43) or age (p ¼ 0.57). Subjects with mild ID scored higher on the total CAMCOG-DS score at baseline than patients with moderate ID (mean 83.9 vs 68.7; p < 0.001). At follow up, 10 patients developed AD dementia. The repeated longitudinal CAMCOG-DS evaluation in those subjects who progressed to AD dementia revealed an accelerated rate of change in total CAMCOG-DS scores (mean change after 1, 2 and 3 years was -9.6, -12.33 and -22.4, respectively). Memory, language and visual perception were the earliest cognitive domains affected. In healthy DS subjects, total CAMCOG-DS scores remained stable. When stratifying by age (< 40 and 40 years), only scores on memory CAMCOG-DS subscale declined significantly in older healthy DS patients. Conclusions: CAMCOG-DS is a sensitive neuropsychological battery to assess cognitive decline in DS patients who progress to dementia. However, cross-sectional CAMCOG-DS scores depend greatly on severity of ID. Therefore, for AD diagnosis in DS subjects, individual longitudinal change should be used. P4-321
RELATIONSHIP BETWEEN THE EXCESS OF EEG THETA ACTIVITY AND COGNITIVE PERFORMANCE IN HEALTHY ELDERLY SUBJECTS
Susana Angelica Castro Chavira1, Thalıa Fernandez2, Catalina Alatorre2, Sergio Sanchez-Moguel2, Marisol Rincon3, Thalıa Harmony2, Jimena Sandoval2, Marbella Espino4, 1Instituto de Neurobiologıa, Universidad Nacional Autonoma de Mexico, Queretaro, Mexico; 2Instituto de Neurobiologıa, UNAM, Queretaro, Mexico; 3Universidad Autonoma de Queretaro, Queretaro, Mexico; 4Centro Estatal de Salud Mental, Secretarıa de Salud del Estado de Queretaro, Queretaro, Mexico. Contact e-mail: [email protected] Background: Excess of theta EEG activity predicts cognitive decline 7-10 years before its presentation (Prichep et al, 2006). NEUROPSI is a neuropsychological test normalized for the Mexican population that thoroughly explores cognitive functions. Methods: Twenty eight right-handed healthy subjects older than 60 years were selected. They have no
P904
Poster Presentations: P4
neurological or psychiatric disorders.Their blood count,cholesterol test, triglycerides, glucose and TSH levels are normal, and their IQ is superior to 85.Their EEGs were recorded in the 19 leads of the 10-20 International System, considering the short-circuited earlobes as reference. Z values of Absolute Power corrected by Geometric Power were computed to separate the subjects into two groups: excess of theta (ET; n ¼ 16) or theta between normal limits (NT; n ¼ 12). Differences between groups of the NEUROPSI scores were analyzed using multivariate non-parametric permutation analysis (Galan et al., 1998). Results: There were no differences between groups in the sepatared cognitive processes (attention, memory coding or retrieval, language, reading comprehension, writing, or executive functions). However, the ET group showed a significantly lower performance in the total score of the NEUROPSI test (p ¼ 0.05). Conclusions: There were no significant differences between subjects with EEG risk to develop cognitive decline (ET) and without EEG risk (NT) for any of the individual cognitive processes evaluated. Furthermore, the subjects in both groups showed no cognitive deterioration. Even though the subjects with excessive EEG theta activity did not express cognitive deterioration, their performance was poorer than the performance of the subjects with normal EEG.
P4-322
A SUITE OF DISCRIMINATION TASKS TO BEHAVIORALLY ASSESS THE INTEGRITY OF HIPPOCAMPAL PATTERN SEPARATION AND INDIVIDUAL DIFFERENCES IN NEUROCOGNITIVE AGING
Michael A. Yassa, Elizabeth Murray, Zachariah Reagh, Jared Roberts, University of California, Irvine, Irvine, California, United States. Contact e-mail: [email protected] Background: The hippocampus is a critical brain region for episodic memory. It is hypothesized that one of its core computations is pattern separation, the process of disambiguating similar neural inputs into distinct orthogonal representations, a process that depends on the dentate (DG) and CA3 regions. We have previously shown that DG/CA3 pattern separation is reduced in aging (manifesting as a functional rigidity in this region), which is also linked to perforant path integrity as well as performance on neuropsychological tasks that involve fine-level discriminations among mnemonic representations. The latter approach continues to be neurobiologically validated, but it also expanded here to include tasks that assess discrimination along several dimensions of memory (object, spatial, temporal). Methods: In the object discrimination task, subjects incidentally encode pictures and during test they view some of the same items (targets), some new items (foils), and some similar items (lures). They are asked to make a recognition judgment. In the spatial discrimination task, participants incidentally encode objects presented in 1 of 31 possible locations and during test they view the same objects and asked to indicate whether the location of the items has changed from study. Some items are presented in exactly the same location and some are presented in different locations on the screen. In the temporal discrimination task, participants incidentally encode objects in sequences of 30 items and during are shown pairs of objects that were presented during study and asked to indicate which one was presented first. Results: We show that older adults can exhibit one of two neuropsychological profiles across all tasks: (1) mild deficits with a recovery (relative to young) at the lowest levels of interference (aged-unimpaired AU), or (2) more severe deficits with no recovery even when interference is minimized (agedimpaired AI). Conclusions: We suggest that the AI group is likely more susceptible to AD brain pathologies and propose that our tools can be used as an early diagnostic/risk marker. These translational tools bridge from computational and animal models of episodic memory to human cognition and significantly expand our understanding of cognitive changes in aging and Alzheimer’s disease.
P4-323
VALIDATION OF THE CHINESE VERSION OF RELEVANT OUTCOME SCALE FOR ALZHEIMER’S DISEASE (ROSA)
Qihao Guo, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China. Contact e-mail: [email protected] Background: The Relevant Outcome Scale for Alzheimer’s disease (ROSA) is a novel observer rating scale developed for daily clinical practice, with characteristics of easy and quick administration, multi-domain assessment, relevance for all AD severity stages, and suitability for long-term monitoring disease progression etc. This study was to verify the validity of the Chinese version of ROSA. Methods: The original English version of ROSA included 16 items was translated into Chinese and back-translated to verify by the study group. A total of 332 outpatients diagnosed with probable AD according to the criteria of NIA-AA guideline were recruited and assessed with ROSA and other standard Chinese rating scales which frequently used for the assessments of AD. Construct and concurrent validities of the Chinese version of ROSA were measured. Correlations of the total score of ROSA with scores of single item, subscales, and the other assessments were analyzed by Pearson correlation test or Spearman correlation analysis. Results: The scores of each single item were significantly correlated with the total score of ROSA (r-value range, 0.363-0.817, P < 0.01). The scores of six dimensions of ROSA, i.e., cognition (item 1-3), communication (item 4-6), behavior (item 7-11), function (item12-14), quality of life (item 15) and caregiver burden (item 16) were highly correlated with the total score of ROSA (r-value range, 0.638w0.855, P < 0.01). The score of ROSA was significantly correlated with the scores of Mini Mental State Examination, Mattis Dementia Rating Scale, and Disability Assessment for Dementia (r¼0.441, 0.575, 0.346 respectively, P < 0.01), and significantly negatively correlated with the scores of Alzheimer’s Disease Assessment Scale-cognitive, The Informant Questionnaire on Cognitive Decline in the Elderly, Neuropsychiatric Inventory, and Zarit Caregiver Burden Interview ((r¼-0.576, -0.540, -0.472, -0.346 respectively, P < 0.01). Conclusions: The Chinese version of ROSA is a valid and easyadministrative instrument to assess Chinese patients with AD and worth to be applied in the clinical practice and clinical studies. P4-324
UTILITY OF A NEUROPSYCHOLOGICAL BATTERY FOR DISCERNING DEMENTIA WITH LEWY BODIES FROM ALZHEIMER’S DISEASE
Hajime Tabuchi, Mika Konishi, Daisuke Ito, Bun Yamagata, Mizuki Oka, Masaru Mimura, Keio University, Tokyo, Japan. Contact e-mail: tabuchi@ a8.keio.jp Background: Dementia with Lewy bodies (DLB), the second most common cause of degenerative dementia after Alzheimer’s disease (AD), is
Table 1 Demographics and scores of the rating scales by stage of severity of AD (Mean6SD) Items
Early stage n¼89
Age 70.53 (9.36) ROSA 117.98 (21.27) MMSE 19.72 (2.15) DRS 113.73 (11.29) ADAS- 28.70 (9.25) cog IQCODE 63.83 (9.28) DAD (%) 84.75 (18.60) NPI 5.93 (4.90) ZBI 33.35 (18.37)
Moderate stage n¼162
Late stage n¼81
Total n¼332
70.58 (10.10) 100.27 (24.62) 14.80 (2.89) 88.99 (13.10) 40.42 (12.52)
68.59 (9.50) 79.01 (23.38) 8.23 (3.41) 66.11 (16.40) 53.72 (9.46)
70.08 (9.77) 99.83 (27.24) 14.50 (5.01) 90.71 (2.15) 53.71 (9.46)
68.63 (8.45) 82.86 (18.20) 7.41 (4.69) 37.19 (15.73)
75.95 (3.68) 69.11 (8.95) 60.19 (19.30) 77.78 (21.11) 9.51 (5.78) 7.52 (5.18) 38.20 (16.11) 36.38 (16.63)
APATHY MAY LEAD TO DEMENTIA IN PATIENTS WITH PARKINSON’S DISEASE
Annalena Venneri, Hamad Alzahrani, University of Sheffield, Sheffield, United Kingdom. Contact e-mail: [email protected] Background: Apathy refers to a combination of behavioural, emotional and cognitive features that lead to reduced interest and participation in daily life activities. Apathy is considered one of the most common neuropsychiatric symptoms in Parkinson’s Disease (PD). The prevalence of apathy in PD is approximately 40%. Few studies have investigated the cognitive and neuroanatomical correlates of apathy in PD. From apathy studies in Alzheimer’s disease and other neurological disorders we expected to find deficits in frontal regions and in cognitive functions associated with frontal and temporal structures. Methods: Forty PD patients in the early stages of the disease (18 with apathy and 22 without apathy) underwent extensive neuropsychological screening, neuropsychiatric assessment using the Neuropsychiatric Inventory, structural MRI scanning and neurological examination. A voxel-based multiple regression analysis was used to measure negative correlation between grey matter volumes and apathy scores. Results: Higher apathy scores correlated with lower grey matter volume in several brain areas including the left insula, left inferior frontal gyrus, left middle frontal gyrus, left medial frontal gyrus, right anterior cingulate and the left superior temporal gyrus. Patients with apathy had lower scores in all cognitive tests. However, significant impairments were found in tests assessing executive functions (Letter Fluency Test and Stroop Test) and a trend-level significant difference was observed in memory tests (Rey 15-word Memory Test and Category Fluency Test) in patients with apathy when compared with patients without apathy. Conclusions: Apathy was associated with greater levels of atrophy in the frontal cortex, temporal cortex and anterior cingulate as well as overall lower level of cognitive performance, particularly in executive function and
P903
memory skills. These findings are in line with results from studies of other neurological conditions. For instance, a similar pattern of executive dysfunction has been reported in apathetic patients with PD with dementia and apathetic patients with Alzheimer disease. Apathy appears to be a risk factor for cognitive impairments in PD and might be a useful clinical indicator of dementia risk in PD. P4-320
NEUROPSYCHOLOGICAL ASSESSMENT OF ADULTS WITH DOWN SYNDROME USING THE CAMCOG-DS: A LONGITUDINAL COHORT STUDY
Bessy Benejam1, Laura Videla2, Susana Fernandez2, Maria CarmonaIragui3, Sebastian Videla2, Juan Fortea4, 1Catalan Down Syndrome Foundation, Barcelona, Spain; 2Catalan Down Syndrome Foundation, Barcelona, Spain; 3Biomedical Research Institute Sant Pau, Barcelona, Spain; 4Catalan Down Syndrome Foundation, Barcelona, Spain. Contact e-mail: [email protected] Background: Dementia caused by Alzheimer’s disease (AD) commonly affects the adult population with Down’s syndrome (DS). However, AD diagnosis represents a diagnostic challenge due to the intellectual disability associated with DS and to a lack of appropriate instruments. Methods: Prospective longitudinal 3 year cohort study. Forty-four healthy DS were recruited from the Down Medical Centre. We included only subjects with mild or moderate intellectual disability (ID) (DSM-IV and ICD-10 criteria). Subjects with cognitive and/or functional decline at baseline were excluded. Subjects underwent annual neuropsychological assessments using CAMCOG-DS. An evaluation for progression to AD was performed blinded to CAMCOG-DS scores. Results: Mean age at baseline was 38.8 years (SD 10.14). Twenty-seven patients were males (61.4%). Eighteen patients had mild ID (40.9%). CAMCOG-DS scores at baseline were related to severity of ID, but were not related to gender (p ¼ 0.43) or age (p ¼ 0.57). Subjects with mild ID scored higher on the total CAMCOG-DS score at baseline than patients with moderate ID (mean 83.9 vs 68.7; p < 0.001). At follow up, 10 patients developed AD dementia. The repeated longitudinal CAMCOG-DS evaluation in those subjects who progressed to AD dementia revealed an accelerated rate of change in total CAMCOG-DS scores (mean change after 1, 2 and 3 years was -9.6, -12.33 and -22.4, respectively). Memory, language and visual perception were the earliest cognitive domains affected. In healthy DS subjects, total CAMCOG-DS scores remained stable. When stratifying by age (< 40 and 40 years), only scores on memory CAMCOG-DS subscale declined significantly in older healthy DS patients. Conclusions: CAMCOG-DS is a sensitive neuropsychological battery to assess cognitive decline in DS patients who progress to dementia. However, cross-sectional CAMCOG-DS scores depend greatly on severity of ID. Therefore, for AD diagnosis in DS subjects, individual longitudinal change should be used. P4-321
RELATIONSHIP BETWEEN THE EXCESS OF EEG THETA ACTIVITY AND COGNITIVE PERFORMANCE IN HEALTHY ELDERLY SUBJECTS
Susana Angelica Castro Chavira1, Thalıa Fernandez2, Catalina Alatorre2, Sergio Sanchez-Moguel2, Marisol Rincon3, Thalıa Harmony2, Jimena Sandoval2, Marbella Espino4, 1Instituto de Neurobiologıa, Universidad Nacional Autonoma de Mexico, Queretaro, Mexico; 2Instituto de Neurobiologıa, UNAM, Queretaro, Mexico; 3Universidad Autonoma de Queretaro, Queretaro, Mexico; 4Centro Estatal de Salud Mental, Secretarıa de Salud del Estado de Queretaro, Queretaro, Mexico. Contact e-mail: [email protected] Background: Excess of theta EEG activity predicts cognitive decline 7-10 years before its presentation (Prichep et al, 2006). NEUROPSI is a neuropsychological test normalized for the Mexican population that thoroughly explores cognitive functions. Methods: Twenty eight right-handed healthy subjects older than 60 years were selected. They have no
P904
Poster Presentations: P4
neurological or psychiatric disorders.Their blood count,cholesterol test, triglycerides, glucose and TSH levels are normal, and their IQ is superior to 85.Their EEGs were recorded in the 19 leads of the 10-20 International System, considering the short-circuited earlobes as reference. Z values of Absolute Power corrected by Geometric Power were computed to separate the subjects into two groups: excess of theta (ET; n ¼ 16) or theta between normal limits (NT; n ¼ 12). Differences between groups of the NEUROPSI scores were analyzed using multivariate non-parametric permutation analysis (Galan et al., 1998). Results: There were no differences between groups in the sepatared cognitive processes (attention, memory coding or retrieval, language, reading comprehension, writing, or executive functions). However, the ET group showed a significantly lower performance in the total score of the NEUROPSI test (p ¼ 0.05). Conclusions: There were no significant differences between subjects with EEG risk to develop cognitive decline (ET) and without EEG risk (NT) for any of the individual cognitive processes evaluated. Furthermore, the subjects in both groups showed no cognitive deterioration. Even though the subjects with excessive EEG theta activity did not express cognitive deterioration, their performance was poorer than the performance of the subjects with normal EEG.
P4-322
A SUITE OF DISCRIMINATION TASKS TO BEHAVIORALLY ASSESS THE INTEGRITY OF HIPPOCAMPAL PATTERN SEPARATION AND INDIVIDUAL DIFFERENCES IN NEUROCOGNITIVE AGING
Michael A. Yassa, Elizabeth Murray, Zachariah Reagh, Jared Roberts, University of California, Irvine, Irvine, California, United States. Contact e-mail: [email protected] Background: The hippocampus is a critical brain region for episodic memory. It is hypothesized that one of its core computations is pattern separation, the process of disambiguating similar neural inputs into distinct orthogonal representations, a process that depends on the dentate (DG) and CA3 regions. We have previously shown that DG/CA3 pattern separation is reduced in aging (manifesting as a functional rigidity in this region), which is also linked to perforant path integrity as well as performance on neuropsychological tasks that involve fine-level discriminations among mnemonic representations. The latter approach continues to be neurobiologically validated, but it also expanded here to include tasks that assess discrimination along several dimensions of memory (object, spatial, temporal). Methods: In the object discrimination task, subjects incidentally encode pictures and during test they view some of the same items (targets), some new items (foils), and some similar items (lures). They are asked to make a recognition judgment. In the spatial discrimination task, participants incidentally encode objects presented in 1 of 31 possible locations and during test they view the same objects and asked to indicate whether the location of the items has changed from study. Some items are presented in exactly the same location and some are presented in different locations on the screen. In the temporal discrimination task, participants incidentally encode objects in sequences of 30 items and during are shown pairs of objects that were presented during study and asked to indicate which one was presented first. Results: We show that older adults can exhibit one of two neuropsychological profiles across all tasks: (1) mild deficits with a recovery (relative to young) at the lowest levels of interference (aged-unimpaired AU), or (2) more severe deficits with no recovery even when interference is minimized (agedimpaired AI). Conclusions: We suggest that the AI group is likely more susceptible to AD brain pathologies and propose that our tools can be used as an early diagnostic/risk marker. These translational tools bridge from computational and animal models of episodic memory to human cognition and significantly expand our understanding of cognitive changes in aging and Alzheimer’s disease.
P4-323
VALIDATION OF THE CHINESE VERSION OF RELEVANT OUTCOME SCALE FOR ALZHEIMER’S DISEASE (ROSA)
Qihao Guo, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China. Contact e-mail: [email protected] Background: The Relevant Outcome Scale for Alzheimer’s disease (ROSA) is a novel observer rating scale developed for daily clinical practice, with characteristics of easy and quick administration, multi-domain assessment, relevance for all AD severity stages, and suitability for long-term monitoring disease progression etc. This study was to verify the validity of the Chinese version of ROSA. Methods: The original English version of ROSA included 16 items was translated into Chinese and back-translated to verify by the study group. A total of 332 outpatients diagnosed with probable AD according to the criteria of NIA-AA guideline were recruited and assessed with ROSA and other standard Chinese rating scales which frequently used for the assessments of AD. Construct and concurrent validities of the Chinese version of ROSA were measured. Correlations of the total score of ROSA with scores of single item, subscales, and the other assessments were analyzed by Pearson correlation test or Spearman correlation analysis. Results: The scores of each single item were significantly correlated with the total score of ROSA (r-value range, 0.363-0.817, P < 0.01). The scores of six dimensions of ROSA, i.e., cognition (item 1-3), communication (item 4-6), behavior (item 7-11), function (item12-14), quality of life (item 15) and caregiver burden (item 16) were highly correlated with the total score of ROSA (r-value range, 0.638w0.855, P < 0.01). The score of ROSA was significantly correlated with the scores of Mini Mental State Examination, Mattis Dementia Rating Scale, and Disability Assessment for Dementia (r¼0.441, 0.575, 0.346 respectively, P < 0.01), and significantly negatively correlated with the scores of Alzheimer’s Disease Assessment Scale-cognitive, The Informant Questionnaire on Cognitive Decline in the Elderly, Neuropsychiatric Inventory, and Zarit Caregiver Burden Interview ((r¼-0.576, -0.540, -0.472, -0.346 respectively, P < 0.01). Conclusions: The Chinese version of ROSA is a valid and easyadministrative instrument to assess Chinese patients with AD and worth to be applied in the clinical practice and clinical studies. P4-324
UTILITY OF A NEUROPSYCHOLOGICAL BATTERY FOR DISCERNING DEMENTIA WITH LEWY BODIES FROM ALZHEIMER’S DISEASE
Hajime Tabuchi, Mika Konishi, Daisuke Ito, Bun Yamagata, Mizuki Oka, Masaru Mimura, Keio University, Tokyo, Japan. Contact e-mail: tabuchi@ a8.keio.jp Background: Dementia with Lewy bodies (DLB), the second most common cause of degenerative dementia after Alzheimer’s disease (AD), is
Table 1 Demographics and scores of the rating scales by stage of severity of AD (Mean6SD) Items
Early stage n¼89
Age 70.53 (9.36) ROSA 117.98 (21.27) MMSE 19.72 (2.15) DRS 113.73 (11.29) ADAS- 28.70 (9.25) cog IQCODE 63.83 (9.28) DAD (%) 84.75 (18.60) NPI 5.93 (4.90) ZBI 33.35 (18.37)
Moderate stage n¼162
Late stage n¼81
Total n¼332
70.58 (10.10) 100.27 (24.62) 14.80 (2.89) 88.99 (13.10) 40.42 (12.52)
68.59 (9.50) 79.01 (23.38) 8.23 (3.41) 66.11 (16.40) 53.72 (9.46)
70.08 (9.77) 99.83 (27.24) 14.50 (5.01) 90.71 (2.15) 53.71 (9.46)
68.63 (8.45) 82.86 (18.20) 7.41 (4.69) 37.19 (15.73)
75.95 (3.68) 69.11 (8.95) 60.19 (19.30) 77.78 (21.11) 9.51 (5.78) 7.52 (5.18) 38.20 (16.11) 36.38 (16.63)