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Renal graft in a protein C deficient patient under protein C concentrate infusion
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FIBRINOLYSIS
304 Retention of the FDP level In blood serum in patients with acute postviral glomerulonephritis STECIWXO A, SZEWCZYK Z, DUTKIEWICZ K RABCZYNSKJ Nephrologv Depamnent and Clinic of Medical Academy, Wroclaw, Poland
Among patients treated in our clinic in 1984-1989 because of acute glomerulonephritis, in 17 cases post-influenza glomerulonephritis was diagnosed. Anamnestic data, epidemiology and viral studies of pharyngeal swabs showed presence of influenza virus type A or B depending on epidemic. Other cases of patients with suggestions of viral infections but not confirmed by viral studies were not analyzed. Biochemical and immunological studies of blood serum were carried out in all patients. Kidney biopsy was
Changes in hemostatic after neonatal thymectomy LAKOVA E, *PENKOVA T, *MENOT/ K UZUNOVA A Department of Pathophysiology, *Department of Chemkhy and Biochemise, Medical Institute, Pleven ,Bulgaria
The effects of neonatal thymectomy (NI) on the levels of main serine protease inhibitors -antithrombin III (AT III) and as-antiplasmin (AP) and fibrinopeptide A (FPA) were investigated in male Wistar rats at 15 w of age (n=30). The control group included age matched rats with sham thymectomy (ST) (n=25). The mean activity of both AT III and AP (measured by calorimetric methods) were significantly higher in NT as compared to ST (12.2824.9 III/ml vs 8.00~500 IU/ml, ~~0.01, and 0.7220.30 IU/ml vs 05420.29 IU/ml, ~~0.05, respectively). The level of FPA (measured by ELISA method) was decreased in NT as compared to ST (1.72kO.55 ng/ml vs 6.17kO.56 rig/ml,
306 Renal graft in a protein C deficient patient under protein C concentrate infusion NGUYEN P, *TOUPANCE 0, **BRANDTB, ***BURNOUF T, POTRON G, *CHANARD J, ***GOUDEMAND M Laboratoire central d’Ht!matologie, CHU Robert-Deb&, Reims Ckdex, *Unitk de Nt”phrologie,CHU Makon-Blanche, Reims Ct!dex, **Unitt! d’Urologie, CHU Robert-Debrk, Reims Ckdex, ***Centre RQional de lIans$.&on Sanguine, Lille, France
We report the case of a 59 year old patient who was presenting a long standing history of renal failure and thrombotic events. Protein C type II deficiency was diagnosed in patients and two family members. When dialysis was not feasible and effective by hemodialysis or intraperitoneally, the indication of renal graft was discussed as an ultimate alternative. Preliminary infusion and results of hemostatic
taken in majority of cases. Retention of sialic acid level, /?-glucuronidase, as-microglobulin ASO, the titre of complete haemolytic complement activity, presence of circulating immune complexes, concentration of FDP in blood serum and their 24 hours excretion with urine were analyzed in details. The obtained results led to the following conclusions: 1) In 48% of patients a clearly higher concentration of FDP in blood serum was discovered and in 22% of patients an increase of 24 hours- FDP excretion in urine was found. 2) There was no statistically significant correlation between FDP concentration in blood serum and in urine. 3) In case of all patients an increase of sialic acid concentration in blood serum was noted as well as its gradual decrease with viral infection extinction.
pcO.001). The thymectomized rats had a significant leukopenia (p
and fibrinolytic parameters allowed us to plan surgical procedure. We present the preparation and protocol of infusion we used to perform successfully this renal graft. Infusion was repeated every 12 hours after surgery and maintained during 15 days. The choice of the donor, the reanimation during and after surgery are presented. The influence of pathology (renal failure, dialysis) and of possible prothrombotic (cyclosporin A, high dose of steroids) as well as antithrombotic therapy (low molecular weight heparin) are also discussed.
FIBRINOLYSIS
304 Retention of the FDP level In blood serum in patients with acute postviral glomerulonephritis STECIWXO A, SZEWCZYK Z, DUTKIEWICZ K RABCZYNSKJ Nephrologv Depamnent and Clinic of Medical Academy, Wroclaw, Poland
Among patients treated in our clinic in 1984-1989 because of acute glomerulonephritis, in 17 cases post-influenza glomerulonephritis was diagnosed. Anamnestic data, epidemiology and viral studies of pharyngeal swabs showed presence of influenza virus type A or B depending on epidemic. Other cases of patients with suggestions of viral infections but not confirmed by viral studies were not analyzed. Biochemical and immunological studies of blood serum were carried out in all patients. Kidney biopsy was
Changes in hemostatic after neonatal thymectomy LAKOVA E, *PENKOVA T, *MENOT/ K UZUNOVA A Department of Pathophysiology, *Department of Chemkhy and Biochemise, Medical Institute, Pleven ,Bulgaria
The effects of neonatal thymectomy (NI) on the levels of main serine protease inhibitors -antithrombin III (AT III) and as-antiplasmin (AP) and fibrinopeptide A (FPA) were investigated in male Wistar rats at 15 w of age (n=30). The control group included age matched rats with sham thymectomy (ST) (n=25). The mean activity of both AT III and AP (measured by calorimetric methods) were significantly higher in NT as compared to ST (12.2824.9 III/ml vs 8.00~500 IU/ml, ~~0.01, and 0.7220.30 IU/ml vs 05420.29 IU/ml, ~~0.05, respectively). The level of FPA (measured by ELISA method) was decreased in NT as compared to ST (1.72kO.55 ng/ml vs 6.17kO.56 rig/ml,
306 Renal graft in a protein C deficient patient under protein C concentrate infusion NGUYEN P, *TOUPANCE 0, **BRANDTB, ***BURNOUF T, POTRON G, *CHANARD J, ***GOUDEMAND M Laboratoire central d’Ht!matologie, CHU Robert-Deb&, Reims Ckdex, *Unitk de Nt”phrologie,CHU Makon-Blanche, Reims Ct!dex, **Unitt! d’Urologie, CHU Robert-Debrk, Reims Ckdex, ***Centre RQional de lIans$.&on Sanguine, Lille, France
We report the case of a 59 year old patient who was presenting a long standing history of renal failure and thrombotic events. Protein C type II deficiency was diagnosed in patients and two family members. When dialysis was not feasible and effective by hemodialysis or intraperitoneally, the indication of renal graft was discussed as an ultimate alternative. Preliminary infusion and results of hemostatic
taken in majority of cases. Retention of sialic acid level, /?-glucuronidase, as-microglobulin ASO, the titre of complete haemolytic complement activity, presence of circulating immune complexes, concentration of FDP in blood serum and their 24 hours excretion with urine were analyzed in details. The obtained results led to the following conclusions: 1) In 48% of patients a clearly higher concentration of FDP in blood serum was discovered and in 22% of patients an increase of 24 hours- FDP excretion in urine was found. 2) There was no statistically significant correlation between FDP concentration in blood serum and in urine. 3) In case of all patients an increase of sialic acid concentration in blood serum was noted as well as its gradual decrease with viral infection extinction.
pcO.001). The thymectomized rats had a significant leukopenia (p
and fibrinolytic parameters allowed us to plan surgical procedure. We present the preparation and protocol of infusion we used to perform successfully this renal graft. Infusion was repeated every 12 hours after surgery and maintained during 15 days. The choice of the donor, the reanimation during and after surgery are presented. The influence of pathology (renal failure, dialysis) and of possible prothrombotic (cyclosporin A, high dose of steroids) as well as antithrombotic therapy (low molecular weight heparin) are also discussed.