Repertoire cloning process, products derived therefrom and uses for said products

• les derniers brevets deposes: morceaux choisis • realisee en collaboration avec I'inpi

AGRICULTURE AGROINDUSTRIE Productions animales > Gene marker associated with swine proliferacy (BA Didion and MA Johns, US). Dekalb Swine Breeders Inc and Northern Illinois University W WO 96/33288. PCT A random amplification method for determining swine genetic markers associated with small and large Jitter sizes is provided. One such marker is an approximatively 270 base-pair amplification product... This marker can be used to inform breeding programs designed to increase the litter size of certain swine breeds.

Productions veglHales > Transgenic plants with

altered senescence characteristics (RM Amasino and S Gan, US). Wisconsin Alumni Resarch Foundation and the inventors N°WO 96/29858. PCT

> Use of Streptomyces bacteria to control plant pathogens and degrade turf thatch (DL Crawford, US). Idaho Research Foundation and the inventor W WO 96/29874, PCT This invention relates to biocontrol formulations suitable for reducing the susceptibility of plants to fungal phytopathogens and for degrading turf thatch...

>

Genetic sequences conferring nematode resistance in plants and uses therefor (ES Lagudah, AU). Commonwealth Scientific and Industrial Research Organisation and the inventor N" WO 96/30517, PCT The present invention relates generally to a nucleic acid molecule encoding, or complementary to a nucleic acid molecule encoding, a polypeptide which confers, enhances, or otherwise facili-

tares resistance to J nematode in a plant cell...

> Regeneration of both plant tissues and transgenic plant tissues using a new plant hormone-5-bromoindole-3-acetic acid (JJ Lin et ai, US). Life Technologies Inc W WO 96/34089. PCT The present invention describes the use of 5-hrornoindole-Laccric acid 15B-lAA) as an auxin afb:ting plant cell growth ...

> Method for production of plant biological products in precocious neomorphic embryoids (SR Wann, US). Union Camp Corp W WO 96/34522. PCT The present invention relates to making precocious ncomorphic embryoids (PNE) and their use for producing biological products. Specifically, the invention provides a method for increasing taxol production from embryogenic Taxus cultures...

Alimentation > Procede d'lnteresterification de phospholipides (0 Chmiel et ai, CH). Societe des produits Nestle SA W 739985, EP. Un precede dintersesterification d'un phospholipide avec un triacylglycerol consiste it utiliser un systeme enzymarique constitue d'une lipase immobilisee et d'une phospholipase imrnobilisee, Les phospholipides obtenus peuvent etre utilises dans des systernes ernulsionnes ou dans des enrobages pour poudres instantaneisees,

> High trehalose content

syrup (K Okada et ai, JP). Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo W 739986, EP.

> Barley

~-amylase structural gene (N Yoshigi and Y Okada, JP). Sapporo Breweries Ltd W WO 96/30525, PCT.

> Bread-improving addi-

tive comprising a xylano-

lytic enzyme (OB Jorgensen et ai, OK). Novo Nordisk AlS and the inventors N" WO 96/32472. PCT The prcscnr invcnrion relates to brcad-uuprovi nu additives ...

> Ensemencement par Geotrichum candidum au cours du maltage de cereales ou autres vegetaux (P Boivin et M'B Malanda, FR). Instirur fLlI1<;ais des boissons. de la br.isseri« maltcric et Irs in H'ntCLI rs W WO 96/34085. ret

SANTE Pr u t ein es et p e pt i d es > New chemokine expressed in eosinophils (0 Bandman et ai, US). lncyte Pharmaceuticals Inc W WO 96/32481. PCl

> Genetic sequences and proteins related to Alzheimer's disease, and uses therefor (PH George-Hyslop et ai, CAl. HSC Research and Development Ltd Partnership, the Governing Council of the University of Toronto and the inventors W WO 96/34099, PCl The present invention describes the identification, isolation, sequencing and characterization of two human presenilin genes, PS-l and PS-2, mutations which lead to familial Alzheimer's disease ... Nucleic acids and proteins comprising or derived from the presenilins are useful in screening and diagnosing Alzheimer's disease ...

Macromolecuies > Nucleic acid ligands of tissue target (A Sthephens at ai, US). Nexstar Pharmaceuticals Inc and Schering AG W WO 96/34874, PCl This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tis-

sue targets, and the methods for obtaining such ligands...

Antibiotiques > Procede d'identification bacterienne et de determination de la sensibilite de bacteries it des antibiotiques et appareil de supports de mesure pour la mise en ceuvre de ce precede (J Bajard, FR). Pasteur Sanofi Diagnositcs W 742284 EP > Glycopeptide antibiotic derivatives (RD Cooper et ai, US). Eli Lilly and Co and the inventors W WO 96/30401, PCl The present invention provides glycopeptide antibiotic derivative compounds. These derivatives compounds possess antibacterial activity against a wide varierv of bacteria, including activirv against vancomycinresistant isolates ....

Diagnostic > Isolated 55 to 75 kDa protein which binds to prion protein (RR Brentani et ai, BR). Ludwig Institute for Cancer Resarch and the inventors W WO 96/32128, PCl The invention involves isolated anti prion-protein binding proteins which have molecular weights of from about 55 kD to about 72 kD as determined by SDSPAGE. Also described is a peptide derived from an isolated anti-prion protein binding protein. Diagnostic uses for each of these molecules are discussed. > Genetic markers for breast and ovarian cancer (MC King et ai, US). The Regents of the University of California W WO 96/33271, PCT. Specific BRCAI mutations, PCR primers and hybridization probes are used in nucleic acid-based methods for diagnostic of inheritable breast cancer susceptibility... > Repertoire cloning process, products derived therefrom and uses for BIOFUTUR 163 • Janvier 1997 43

•••

• •• said products (GF Okasinski and DG Fry, US). Abbott Laboratories W WO 96/33279. PCT A repertoire cloning process for producing mammalian monoclonal antibodies. Also provided are methods for using these monoclonal antibodies, and kits which contain these monoclonal antibodies.

Vaccins > Vaccine for the immunoprophylaxis of the infection from feline immunodeficiency virus in the domestic cat (M Bendinelli et ai, IT). Istituto Superiore di Sanita' , Universita' Degli Studi di Pisa and the inventors W WO 96/30045. PCT It is disclosed an immunizing vaccine for prophylaxis of the infection from feline immunodeficiency virus and/or the pathological syndrome know as feline AIDS induced by said virus ... > A pluripotent vaccine against enveloped viruses (DL Morton, US). John Wayne Cancer Institute W WO 96/33734. PCT

> Malaria peptides and vaccines (01 Baruch et ai, US). Affymax Technologies NV and the inventors W WO 96/33736. PCT The present invention generally relates to novel proteins, and fragments thereof, as well as nucleic acids which encode these proteins and methods of making and using these proteins in both diagnostic and therapeutic applications...

Maladies qene t i qu es > Single chain insulin with high bioactivity (RE Chance et ai, US). Eli Lilly and Co W 741188, EP The instant invention provides polypeptide compounds of the formula b-BPa having significant insulin activity...

i r 1IS > Bispecific reagents for

44 BIOFUTUR 163 • Janvier 1997

AIDS therapy (MW Fanger etal, US). Medarex Inc W 739904, EP Bispecific molecules which react both with the high-affinity Fe receptor of human effector cells and with a virus or virus component arc disclosed ... > Induction of protection against viral infection (M Girard et ai, FR). Institut Pasteur W 742229. EP. This invention relates to monoclonal or polyclonal antibodies having neutralizing properties regarding the infection bv a determined virus, obtained after administration to a host. .. The invention further relates to the use of these antibodies as serotherapeuric drug. > Fragments d'acide nuclelque derives du genome du virus VIH-1, peptides correspondants et leurs applications en tant que reactifs d'evaluation du risque de transmission materno-fcetal du VIH-1 (R Narwa et P Roques, FR). Commissariat l'enerqie atomique W 743364 EP. Fragments d'acide nucleique derives du genome du virus de l'imrnunodeficience humaine de type 1 (VIH-l) ainsi que peptides correspendants et leurs applications en rant que reactits de de pi stage et devaluation du risque de transmission rnaterno-foerale du VIH-l.

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> Modified viral envelope polypeptide (W Anderson et ai, US). Genetic Therapy Inc, University of Southern California and the inventors N° WO 96/30504, PCT A retroviral vector particle having a modified envelope polypeptide wherein a portion of the receptor binding region of the envelope is replaced with a targeting polypeptide which binds to a ligand or a receptor on the targeted cells ... > Gene therapy for transplantation and inflammatory or thrombotic conditions (FH Bach and S Robson, US). Sandoz Ltd, New England

Deaconess Hospital Corp and the inventors W WO 96/30532, PCl A method to render in particular endothelial cells capable of inhibiting platelet and leukocyte-mediated injury and inflammation IS described... > Novel anti-AIDS immunotoxins (GB Kitto, US). Research Development Foundation W WO 96/32416. PCT ... The immunotoxin comprises a toxin chemically conjugated to a monoclonal antibody directed against viral reverse transcriptasc...

> Lignees immortalisees de cellules issues du tissu adipeux humain, leur procede de preparation et leurs applications (AD Strosberg et V Zilberfarb, FR). CNRS et les inventeurs N° WO 96/34100, PCT

SystEnne

mmuntt ai e > Composition destinee a I'induction d'une reponse immunitaire mucosaIe (B Guy et ai, FR). Pasteur Merieux Serums & Vaccins et les inventeurs W WO 96/31235, PCT Linvention a pour objet une composition pharmaceutique destinee a induire chez un rnamrnifere hore, une reponse immunitaire protectrice l'enconrre d'un anrigene, au niveau dun site mucosa! effecteur...

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Apup tus e > Intracellular signaling proteins and methods of use (DV Goeddel and H Hsu, US). Tularik Inc N° WO 96/30404. PCI A novel family of intracellular signaling proteins, exemplified by a tumor necrosis factor-receptor 1 associated death domain protein (TRADD), share a common TRADD sequence and include transducers of signals that modulate cell growth, differenciation and apoprosis.c.

> Apoptosis regulating gene (HS Shin et ai, KR). Korea Green Cross Corp,

Postech Foundation and the inventors N° WO 96/30513. PCI A new Bcl-2 related gene BfI-l, a polypeptide encoded by said gene, and a plasmid and a transformant comprising said gene are disclosed. The gene can be used to detect cancer.

Therapies qeniqu e et cellu lair e > Gene therapy by secretory gland expression (M German et ai, US). The Regents of the University of California N° WO 96/30050, PCI Secretory gland cells, particularly pancreatic and salivary gland cells, are genetically altered to operatively incorporate a gene which expresses a protein which has a desired therapeutic effect on mammalian subject. The expressed protein is secreted directly into the gastrointestinal tract and/or blood stream to obtain therapeutic blood levels of the protein thereby treating the patient in need of the protein ... > Adenovirus vectors for gene therapy (0 Armentano et ai, US). Genzyme Corp W WO 96/30534, PCI The present invention relates to a novel adenovirus vectors for use in gene therapy which are designed to prevent the generation of replicationcompetent adenovirus (RCA) during in vitro propagation and clinical use ...

Bioconversions > Precede de production de vanilline par bioconversion de precurseurs benzeniques (B Audras et J More, FR). Orsan SA N" 2733763, FR. > Hydantoinase from Agrobacterium tumefaciens and its use for the preparation of optically pure N-carbamyl-D-amino acids from racemic hydantoins (JE Weber and DR Durham et ai, US). WR Grace & Co-Conn W 739978. EP. A novel hydantoinase exhibiting high activity and sta-