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Reply to the letter: "Sweet taste disorder and vascular complications in patients with abnormal glucose tolerance"
International Journal of Cardiology 229 (2017) 37
Contents lists available at ScienceDirect
International Journal of Cardiology journal homepage: www.elsevier.com/locate/ijcard
Correspondence
Reply to the letter: "Sweet taste disorder and vascular complications in patients with abnormal glucose tolerance" Tetsuro Tsujimoto Department of Diabetes, Endocrinology, and Metabolism, Center Hospital, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162–8655, Japan
Dr. Karimi et al. noted that the effects of taste on cardiac function have been studied since ancient time. It is particularly interesting to assess whether astringent in taste affects cardiac function in the modern era. The receptors of basic five tastes, namely sweet, salt, bitter, sour, and umami, are mediated by separate populations of selectively tuned taste receptor cells. Recent studies have revealed that cells with taste receptors were not restricted to the taste buds of the tongue; they elaborately control intake and absorption to maintain homeostasis. Although our study focused on the association between sweet taste disorder and vascular complications in patients with abnormal glucose tolerance [1], other tastes may also be associated with important clinical findings. For example, targeting bitter taste receptors may have a therapeutic role in upper respiratory tract infections [2]. In addition,
DOI of original article: http://dx.doi.org/10.1016/j.ijcard.2016.11.295. E-mail address: [email protected].
http://dx.doi.org/10.1016/j.ijcard.2016.11.298 0167-5273/© 2016 Elsevier Ireland Ltd. All rights reserved.
antagonists of taste receptors, including artificial sweeteners and natural ingredients, are being actively researched [3]. Further investigations about taste may lead to better medical care and prevention of diseases.
References [1] T. Tsujimoto, K. Imai, S. Kanda, M. Kakei, H. Kajio, T. Sugiyama, Sweet taste disorder and vascular complications in patients with abnormal glucose tolerance, Int. J. Cardiol. 221 (2016) 637–641. [2] R.J. Lee, J.M. Kofonow, P.L. Rosen, et al., Bitter and sweet taste receptors regulate human upper respiratory innate immunity, J. Clin. Invest. 124 (2014) 1393–1405. [3] J. Suez, T. Korem, D. Zeevi, et al., Artificial sweeteners induce glucose intolerance by altering the gut microbiota, Nature 514 (2014) 181–186.
Contents lists available at ScienceDirect
International Journal of Cardiology journal homepage: www.elsevier.com/locate/ijcard
Correspondence
Reply to the letter: "Sweet taste disorder and vascular complications in patients with abnormal glucose tolerance" Tetsuro Tsujimoto Department of Diabetes, Endocrinology, and Metabolism, Center Hospital, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162–8655, Japan
Dr. Karimi et al. noted that the effects of taste on cardiac function have been studied since ancient time. It is particularly interesting to assess whether astringent in taste affects cardiac function in the modern era. The receptors of basic five tastes, namely sweet, salt, bitter, sour, and umami, are mediated by separate populations of selectively tuned taste receptor cells. Recent studies have revealed that cells with taste receptors were not restricted to the taste buds of the tongue; they elaborately control intake and absorption to maintain homeostasis. Although our study focused on the association between sweet taste disorder and vascular complications in patients with abnormal glucose tolerance [1], other tastes may also be associated with important clinical findings. For example, targeting bitter taste receptors may have a therapeutic role in upper respiratory tract infections [2]. In addition,
DOI of original article: http://dx.doi.org/10.1016/j.ijcard.2016.11.295. E-mail address: [email protected].
http://dx.doi.org/10.1016/j.ijcard.2016.11.298 0167-5273/© 2016 Elsevier Ireland Ltd. All rights reserved.
antagonists of taste receptors, including artificial sweeteners and natural ingredients, are being actively researched [3]. Further investigations about taste may lead to better medical care and prevention of diseases.
References [1] T. Tsujimoto, K. Imai, S. Kanda, M. Kakei, H. Kajio, T. Sugiyama, Sweet taste disorder and vascular complications in patients with abnormal glucose tolerance, Int. J. Cardiol. 221 (2016) 637–641. [2] R.J. Lee, J.M. Kofonow, P.L. Rosen, et al., Bitter and sweet taste receptors regulate human upper respiratory innate immunity, J. Clin. Invest. 124 (2014) 1393–1405. [3] J. Suez, T. Korem, D. Zeevi, et al., Artificial sweeteners induce glucose intolerance by altering the gut microbiota, Nature 514 (2014) 181–186.