Scientific

academy sections scientific Chairman-Robert F. Doerge Chairman -elect-Dale E. Wurster Vice Chairman-Harry B. Kostenbauder ~;ecretary-Rudolph H. Blythe (Papers submitted to the scientific section for presentation at the Dallas meeting were accepted by the secretary of that section but are tIeing presented here by the appropriate "new sections." This has been done in order to expedite the development of the Academy and the several sections representing specific areas of interest.)

breakfast Monday, April 25, 7:30 a.m.-Adolphus, Civic Room II (Executive committee of Academy and presiding officers for sessions on contributed papers.)

first session Tuesday, April 26, 9:00 a.m.-Baker, Crystal Ballroom Industrial Pharmacy and Scientific Sections' Joint SymposiumPresent Concepts of the Biopharmaceutics of Oral Dosage Forms (see industrial pharmacy section for program)

9:45 a.m.-4. Kinetics of Reactions Involved in Penicillin Allergy I. Mechanism of Reaction of Penicillins with Glycine in Alkaline Solution-M.A. Schwartz and Gay-May Wu 10:00 a.m.-5. Utilization of a Model Copolymer to Evaluate the Contribution of Hydrophobic Bonding in Drug Binding-J.B. Nagwekar and H.B. Kostenbauder 10:15 a.m.-6. Interaction of Nonionic Hydrophilic Polymers with Phenols II. Interaction of Phenol, Tannin and Hydroxyphenols with Certain Polyethylene Glycols-B.N. Kabadi and E.R. Hammarlund 10:30 a.m.-7. Diffuse Reflectance Studies of Solid-Solid Interactions II. Interaction of Metallic and Nonmetallic Adjuvants with Anthracene, Prednisone and Hydrochlorothiazide-Michael Bornstein,Ting-fong Chin and John L. Lach 10:45 a.m.-8. Diffuse Reflectance Studies of Solid-Solid Interactions Ill. I nteraction Studies of Oxytetracycline with Metallic and Nonmetallic Adjuvants-John L. Lach and Michael Bornstein 11:00 a.m.-g. Interaction of a Group of Weak Organic Acids and Phenols with Nylon-6-Michael B. Rodell, Wallace L. Guess and John Autian 11:15 a.m.-IO. Permeation Studies of Selected Preservatives through Polyethylene-Mario A. Gonzalez, Wallace L. Guess and John Autian 11:30 a.m.-l1. Sorption and Diffusion Studies of Dicarboxylic Acids with Nylon, 6,6- Part II-R. Kent Stobaugh, H. Berg, W.L. Guess and J. Autian 11:45 a.m.-12. Molecular Orbital Calculations on Sulfonamide Molecules-E.C. Foernzler and A.N. Martin

second session

second session

Monday, April 25, 1:30 p.m.-DMA Room 3A

Tuesday, April 26, 9:00 a.m.-Baker, Terrace Room

Presiding-Louis J. Ravin and John A. Biles

Medicinal Chemistry and Scientific Sections' Joint SymposiumAdvances in Natural Product Chemistry (see section on medicinal chemistry for program)

third session-business Wednesday, April 27, 9:00 a.m.-Baker, Crystal Ballroom 1.

Call to order Chairman's address-Robert F. Doerge Secretary's report-Rudolph H. Blythe Treasurer' s report-Rudolph H. Blythe Committee reports A. Auditing-Louis J. Ravin B. Ebert prize-Howard J. Schaeffer C. Kilmer prize-Melvin R. Gibson D. Physiological testing-Frederick C. Armstrong E. Awards and prizes-E. Roy Hammarlund 6. Unfinished business 7. New business A. Consideration of section dissolution 8. Adjournment

2. 3. 4. 5.

1:30 p.m.-B. The Influence of Ions and Urea on the Surface Activity of Chlorpromazine-Rashmikant M. Patel and George Zografi 1:45 p.m.-14. The Effect of Micelle Formation on the Concen tration Dependence of Surface Tension-Albert J. Flood and L. Dallas Tuck 2:00 p.m.-15. The Effects of Aging and Surfactant Concentration on the Rheology and Droplet Size Distribution of a Nonaqueous Emulsion-R.D. Hamill and R.V. Petersen 2:15 p.m.-16. The Effect of Surfactant Concentration on the Interfacial Viscosity of a Nonaqueous System-R.D. Hamill and R.V. Petersen 2:30 p.m.-17. Kinetics of Metabolism and Urinary Excretion of Dextrorotatory and Levorotatory Mandelic Acid in Humans-J.B. Nagwekar and H.B. Kostenbauder 2:45 p.m.-18. Acetylsalicylic Acid Hydrolysis in Human Blood and Plasma. I. Methodology and in Vitro Studies-P.A. Harris and S. Riegelman

fou rth session Thursday, April 28, 1:30 p.m.-Adolphus, Cactus Room Drug Standards, Analysis and Control and Scientific Sections' Joint Symposium-The Appl ication of Analytical Technics to the Stability of Drugs (see section on drug standards, analysis and control for program)

basic pharmaceutics Chairman-Dale E. Wurster Chairman-elect-John A. Biles Vice Chairman-Harry B. Kostenbaudet Secretary-James E. Tingstad

Academy section chairmen-(Ieft to right, above) Robert F. Doerge, scientific; Dale E. Wurster, basic pharmaceutics, and Lloyd C. Miller, drug standards, analysis and control.

Academy section secretaries-(Ieft to right, below) Rudolph H. Blythe, scientific; James E. Tingstad, basic pharmaceutics, and Dale H. Szulcewski, drug standards, analysis and control.

fi rst session Monday, April 25, 9:00 a.m.-DMA Room 3A Presiding-John L. Lach and John Autian 9:00 a.m.-I. Transition Metal Complexes of Substituted Thiouracils-Edward R. Garrett and Dennis J. Weber 9:15 a.m.-2. The Thermodynamics of Chelation by TetracyclinesLeslie Z. Benet and Jere E. Goyan 9:30 a.m.-3 . A Comparison of the Solubility, Spectral and Kinetic Technics for Studying Complex Formation-Joseph A. Mollica, Jr. and Kenneth A. Connors

Vol. NS6, No. 3, March 1966

121

3:00 p.m.-ISa. Theoretical Formulation of Sustained Release Dosage Forms-J.R. Robinson, H. Stelmach and S.P. Eriksen 3:15 p.m.-Business meeting

third session Tuesday, April 26, 2:30 p.m.-Baker, Texas Room Presiding-Edward G. Rippie and David E. Guttman 2:30 p.m.-19. Interaction of Di- and Tri-Carboxylic Acids with Glutaric Anhydride in Aqueous Solution-J.R. Robinson, A.J. Repta and T. Higuchi 2:45 p.m.-20. Interaction of Acetic Anhydride with Citrate Ions in Aqueous Solution-A. J. Repta, J. R. Robinson and T. Higuchi . 3:00 p.m.-2L Catalytic Effect of Copper (II) Ion on th e HydrolYSIS of Some Esters and Amides-A.J. Agren 3:15 p.m.-22. Kinetics of Solvolysis of Various N,N ' -Disubstituted N-Nitrosoureas in Neutral and Alkaline Solution-Edward R. Garrett and Shigeru Goto 3:30 p.m.-23. Kinetics of Solvolysis of Some 3- and 3,4-Substituted Sydnones-Edward R. Garrett and Parimal J. Mehta 3:45 p.m.-24. Kinetics and Mechanisms of Hydrolysis or I-Substituted 6-Amino-2-Thiouracils-Ting-fong Chin, Wen-hung Wu and John L Lach 4:00 p.m.-25. The Hydrolytic Behavior of Riboflavin and Related Isoalloxazines 1. Studies with 9-Methylisoalloxazine-D.A. Wadke and D.E. Guttman 4:15 p.m.-26. The Hydrolytic Decomposition of Sodium Sulfacetamide in Selected Aqueous Systems-Sr. Francis Mary Schleider, OP, D.M. Eno, J.A. Feldman and A.M. Galinsky 4:30 p.m.-27. The Photochemical Formation of Hydrogen Peroxide in White Lotion USP-E.P Guth and Z. Mansour 4:45 p.m.-2S. The Effect of Organic Inhibitors on in Vitro Activity of Several Antacids-H. Stromberg and R.C. Brogle

fou rth session

9:45 a.m.-44. Factors Affecting the Absorption of Riboflavin in Man-Gerhard Levy and W.J. Jusko 10:00 a.m.-45. The Metabolism of C14 Labeled Glutamic and Pyroglutamic Acid in Animals-W.E. Lange and E.F. Carey 10:15 a.m.-46. Effect of pH on the in Vitro Absorption of Flufenamic Acid-Armando J. Aguiar and Richard J. Fifelski 10:30 a.m.-47 _ The Effect of Some Nonionic Surfactants on the Rate of Release of Aminophylline from Suppositories-J.M. Plaxco, Jr. and C.B. Free 10:45 a.m.-4S. In Vivo Pharmacodynamic Evaluation of Oral Dosage Forms by Whole Body Liquid SCintillometry-G. Hecht, J.E. Christian and G.S. Banker 11:00 a.m.-49_ Studies on the Mechanism of Action of Phenolic Disinfectants VII. Factors Affecting Binding of Phenol Derivatives to Micrococcus Lysodeikticus Cells-J. Judis 11:15a.m.- 50. A Mathematical Treatment of Repetitive-Dose Kinetics-King Chiu Kwan, Maurice P. Zirrith, Robert A. Castello and Arnold D. Marcus 11:30 a.m.-5L Effect of Inert Tablet Ingredients on Drug Absorption Part II. Effect of Various Adjuvants on the Dissolution Rate and Intestinal Absorption of Salicylic Acid-Ganga S. Pandey, Leslie Z. Benet, William E. Johnson and V.N. Bhatia 11:45 a.m.-52. A Study of Possible Mutagenic Effects of Gamma Radiation on Antibiotic-Producing Actinomycetes-Ada R. Dogger and James P. Vacik

drug standards, analysis and control Ch airman-Lloyd C. Miller Chairman-elect-Klaus Florey Vice Chairman-William J. Mader Secretary-Dale H. Szulcewski

first session-business Monday, April 25, 9:00a.m.-DMA Room 3B

Thursday, April 28, 9:00 a.m.-Adolphus, Cactus Room Presiding-William I. Higuchi and James E. Tingstad 9:00a.m.-29. Investigation of Factors Controlling Release of Solid Drug Dispersed in Inert Matrices II. Quantitation of ProceduresS.J. Desai, A.P. Simonelli and W.l. Higuchi 9:15 a.m.-30. Release of Drug Dispersed in Inert Matrices 111. Some Cases Involving the Polyethylene Matrix-S.J. Desai, P. Singh, W.I. Higuchi and A.P. Simonelli 9:30 a.m.-3L The Solubility of the Xanthines, Antipyrine and Several Derivatives in Syrup Vehicles-A.N. Paruta and B.B. Sheth 9:45 a.m.-32 . The Solubility of Succinic Acid in Binary Mixtures as a Function of the Dielectric Constant-A.N. Paruta 10:00 a.m .-33 . Solubilization of Gluco-Corticoids by Aqueous Solutions of Triton WR-1339-Witold Saski 10:15 a.m.-34 . Studies of the Crystal Growth Kinetics and Mechanisms of Sulfathiazole and Methylprednisolone in Various Solvents-P.O. Bernardo and W.I. Higuchi 10:30 a.m.-35. Dissolution Rate Behavior of the Polymorphic Forms of Sulfathiazole and Methylprednisolone-P.O. Bernardo, S.C. Mehta and W.I. Higuchi 10:45 a.m.-36 . Heats of Transition of Methylprednisolone and Sulfathiazole by a Differential Thermal Analysis Method-J. Keith Guillory 11:00 a.m.-37. The Influence of the State of Molecular Aggregation on the Enzymic Hydrolysis of Arylsulfate Esters-T.H. Baxter and H.B. Kostenbauder 11:15 a.m.-3S. Studies on the Aggregation of Denatured Proteins 1. Methodology Based on the Multichannel Particle Counter and Analyzer-N.F.H. Ho and W.I. Higuchi 11:30 a.m.-39. Aggregation of Certain Medicinal Amines in Aqueous Solution of Their Salts-B. Farhadieh, E.R. Hammerlund and N.A. Hall 11:45 a.m.-40. Negative Thixotropy in Flocculated Clay Suspensions-J.C. Samyn and W.Y. Jung

fifth session Friday, April 29, 9:00 a.m.-Adolphus, Danish Room Presiding-Theodore D. Sokoloski and James A. Seitz 9:00 a.m.-4L Hemolysis of Erythrocytes by Antibacterial Preservatives III. Influence of Dimethylsulfoxide on the Hemolytic Activity of Phenol-H.C. Ansel and W.F. Leake 9:15 a.m.-42. A Study of the Retention, Excretion and Distribution of 2,3,5-Triiodobenzoic Acid and Its Metabolites in the Rat-R.D. Ice, C.E. Breckinridge, Jr. and J.E. Christian 9:30 a.m.-43. Physicochemical and Physiologic Factors Affecting the Absorption of Warfarin in Man-R.A. O'Reilly, Eino Nelson and Gerhard Levy

122

Journal of the. AMERICAN PHARMACEUTICAL ASSOCIATION

second session Monday, April 25, 1:30 p.m.-DMA Room 3B Presiding-Lester Chafetz and Richard Poe 1:30 p.m.-I. Determination of Aspirin and Barbiturate Combinations by Nonaqueous Titration-Song-Ling Lin and M.l. Blake 1:45 p.m.-2. The Effect of Diester Type Plasticizers on the Differential Thermal Spectrum of a Polyvinyl Chloride System- R.K. O'Leary, J. Foy, W.L Guess and J. Autian 2:00 p.m.-3. A Quantitative Evaluation of the Heat Stabilizing Properties of Organotin Compounds in Rigid Polyvinyl Chloride Using Differential Thermal Analysis-R.K. O'Leary, J. Foy, W.L Guess and J. Autian 2:15 p.m.-4. A Comparative Study of the Alternating and Direct Current Polarography of Several c,. ' -3-Ketosteroids-James L. Spahr and Adelbert M. Knevel 2:30 p.m.-5. Assay of Methenamine Mandelate and Its Pharmaceutical Preparations by Direct Cerimetric Titration-Lester Chafetz and Charles A. Gaglia, Jr. 2:45 p.m.-6. The Automated Determination of Thiamine in Both Simple Solutions and Complex Preparations-A.J. Khoury and LJ. Cali 3:00 p.m.-7. Separation and Quantitative Determination of Adrenaline Using Thin Layer Chromatography-N.H. Choulis 3:15 p.m.-S. Molecular Interaction of Stereoisomers When in Solid State-N.H. Chou lis 3:30 p.m.-9. The Fluorometric Investigation of Certain Aralkylamines-W.E. Lange and J.M. Theodore, Jr. 3:45 p.m.-IO. A Study of Indicators and EDTA Solutions in the Assay of Calcium Salts-Albert C. Smith 4:00 p.m.-H. Quantitative Analysis of Some Pharmaceutical Powders by Water Absorption Technic-LR. Ciufo and R.M. Cox 4:15 p.m.-12. Determination of in Vitro Release Rates of Sustained Action Preparations by Paper Chromatography and Electrophoresis-H. Schriftman

third session Thursday, April 28, 9:00 a.m.-AdolphUS, Parlor A Presiding-Carl Rehm and John Wind heuser 9:00 a.m.-13. Chemi stry of the Lavine Method for Determining Methionine. Mechanism of Reversible Oxidation with lodineK.H. Gensch and T. Higuchi 9:15 a.m.-14. Ion Pair Extraction of Pharmaceutical Amines . Role of Dipolar Solvating Agents in Extraction of Dextromethorphan-T. Higuchi, A. Hurwitz, A. Michaelis and T. Tan