Scientific abstract sessions

Scientific Abstract Sessions Poster Session

2Medical

Department, C.B.F. LETI, S.A., Tres Cantos, SPAIN, Department, C.B.F. LETI, S.A., Tres Cantos, SPAIN. Fexofenadine HCl 180 mg Provides Greater and Faster Histamine-Induced Flare Suppression Than Desloratadine 5 mg E. O. Meltzer1, S. A. Gillman2, S. Meeves3, Y. Liao3, G. Georges3; 1Research Center, Allergy and Asthma Medical Group, San Diego, CA, 2Division of Allergy and Immunology, Children’s Hospital of Orange County, Orange, CA, 3Aventis Pharma, Bridgewater, NJ. Olopatadine Suppresses Nasal Allergic Reactions A. M. Sanico1, C. Bloom1, C. J. Reynolds1, G. M. Wall2, M. M. Drake2, S. F. Beezley2, A. Togias1; 1Department of Medicine, Johns Hopkins University, Baltimore, MD, 2Alcon Research Ltd., Fort Worth, TX. A Study to Determine if Rhinitis Sufferers Understand What Is Meant by Perennial Nonallergic Rhinitis P. Lieberman; College of Medicine, University of Tennessee, Memphis, TN. Expression of the Cys LT2 Receptor on Mucosal Inflammatory Cells in Patients With Chronic Rhinosinusitis K. Mallett1, Y. Sun1, M. Qiu1, A. R. Sousa2, G. Scadding3, A. Parikh3, T. H. Lee1, C. J. Corrigan1; 1Asthma, Allergy & Respiratory Science, Guy’s, King’s & St. Thomas’ School of Medicine, London, UNITED KINGDOM, 2GlaxoSmithKline, London, UNITED KINGDOM, 3Royal National Throat, Nose and Ear Hospital, London, UNITED KINGDOM. Treatment With Desloratadine Improves Quality of Life and Symptom Scores, Including Nasal Congestion, in Patients With Seasonal Allergic Rhinitis A. Pradalier1, C. Neukirch2, M. Aubier2, F. Saint-Martin3, I. Dreyfus4; 1Hôpital Louis Mourier, Colombes, FRANCE, 2Hôpital Bichat, Paris, FRANCE, 3Villebon-sur-Yvette, FRANCE, 4Schering-Plough, Levallois Perret, FRANCE. T Helper-2 (Th2) Lymphocytes in Chronic Rhinitis: Initiators of the IL-4 Response but Superceded by Mast Cells D. Powe1, C. Jagger1, M. Sisson1, N. S. Jones2; 1School of Molecular Medical Sciences, Queen’s Medical Centre, Nottingham, UNITED KINGDOM, 2Department of Medical and Surgical Sciences, Queen’s Medical Centre, Nottingham, UNITED KINGDOM. Dose-Dependent Effectiveness of Ciclesonide Nasal Spray in the Treatment of Seasonal Allergic Rhinitis (SAR) P. H. Ratner1, J. H. van Bavel2, F. Hampel3, M. A. Wingertzahn4, P. F. Darken4, T. Shah4, S. Hellbardt5, S. Brookman6; 1Sylvana Research Associates, San Antonio, TX, 2Allergy and Asthma Associates, Austin, TX, 3Central Texas Health Research, New Braunfels, TX, 4ALTANA Pharma, Florham Park, NJ, 5ALTANA Pharma, Konstantz, GERMANY, 6Clinical Research and Regulatory Affairs, Teijin America, Inc., Princeton, NJ. Desloratadine Improves Quality of Life and Measures of Impaired Sleep and Daily Activity in Chronic Idiopathic Urticaria J. J. Grob1, J. F. Stalder2, I. Dreyfus3, J. P. Ortonne4; 1Hôpital Sainte Marguerite, Marseille, FRANCE, 2Hôpital Hôtel-Dieu, Nantes, FRANCE, 3Schering-Plough, Levallois Perret, FRANCE, 4Hôpital l’Archet 2, Nice, FRANCE. Regulation of Mast Cell Migration Into the Allergic Nasal Epithelium by RANTES and not SCF C. Ozu, R. Pawankar, R. Takizawa, S. Yamagishi, T. Yagi; Otolaryngology, Nippon Medical School, Tokyo, JAPAN. The Effect of a Novel Inhibitor of Mast Cell Activation on Mediators, Symptoms and Nasal Patency in Allergic Rhinitis 3R&D

2401 Saturday, March 20 11:00 AM to 12:00 PM Advances in Rhinitis and Sinusitis 1 Association Between TLR3 Gene Variants and Japanese Cedar Pollinosis L. Cheng1,2, T. Enomoto3, T. Hirota4, M. Shimizu4, M. Tamari4, T. Shirakawa1,4; 1Department of Health Promotion and Human Behavior, Kyoto University, Kyoto, JAPAN, 2International Research Center for Nasal Allergy, Nanjing Medical University, Nanjing, CHINA, 3Department of Otolaryngology, Japanese Red Cross Society Wakayama Medical Center, Wakayama, JAPAN, 4Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN, Yokohama, JAPAN. 2 Heparin Attenuates the Release of Histamine and Tryptase Induced by AMP Nasal Provocation D. Zeng1, G. Prosperini2, L. Spicuzza2, G. U. Di Maria2, C. Pagano2, R. Polosa2; 1Department of Drug Research and Pharmacological Sciences, CV Therapeutics, Inc., Palo Alto, CA, 2Dip. di Medicina Interna e Specialistica, University of Catania, Catania, ITALY. 3 Desloratadine Inhibits Basal and Histamine-Induced NF-kB Activity Via the Histamine Receptor 1 C. Roumestan1, C. Henriquet1, C. Gougat-Barbera1, P. Demoly2, J. Bousquet2, M. Mathieu1; 1U454, INSERM, Montpellier Cedex 5, FRANCE, 2U454/Service des Maladies Respiratoires, INSERM/CHU, Montpellier Cedex 5, FRANCE. 4 Improved Quality Of Life (QoL) Among Seasonal Allergic Rhinitis (SAR) Patients Treated With Olopatadine HCl Nasal Spray, 0.4% and Olopatadine HCl Nasal Spray, 0.6% Compared to Vehicle F. C. Hampel, Jr.1, P. H. Ratner2, N. J. Amar3, J. H. van Bavel4, D. Mohar5, K. Venkataraman6, G. M. Wall6, M. Brubaker6, M. Drake6, K. Crenshaw6; 1Central Texas Health Research, New Braunfels, TX, 2Sylvana Research, San Antonio, TX, 3Allergy and Asthma Center, Waco, TX, 4Allergy and Asthma Assoc., Austin, TX, 5Kerrville Allergy and Asthma Associates, PA, Kerrville, TX, 6Alcon Research, Ltd., Fort Worth, TX. 5 Correlation Between Disease-Specific and Generic Measures of Quality of Life (QOL) Support Improvement in Nocturnal Rhinitis-Related QOL in Allergic Rhinitis (AR) Patients Treated With Triamcinolone Acetonide Aqueous (TAA AQ) Nasal Spray J. Garcia, P. Diener, Y. Liao, C. Crivera, S. Malieckal, G. Georges; Avenits Pharmaceuticals Inc., Bridgewater, NJ. 6 ARIA Guidelines for Allergic Rhinitis in Specialist Practices. A Randomized Controlled Trial With Ebastine J. Klossek1, F. Neukirch2, P. Gehanno3, T. Bodez4, F. Liard5, N. Janin6, J. Bousquet7; 186021, Hopital de la Milétrie - Dpt ORL, Poitiers, FRANCE, 275018, INSERM 408, Paris, FRANCE, 375018, Groupe Bichat-Claude-Bernard, Paris, FRANCE, 475019, ORL, Paris, FRANCE, 537800, MG, Saint-Epain, FRANCE, 675013, Almirall SAS, Paris, FRANCE, 734000, Faculté de Médecine, Montpellier, FRANCE. 7 Nasal Provocation Tests With Dermatophagoides pteronyssinus, D. farinae, Lepidoglyphus destructor, and Tyrophagus putrescentiae A. Ferrer1, C. Andreu1, M. Casanovas2, V. Iraola3, J. Carnes3, E. Fernandez-Caldas3; 1Hospital de la Vega Baja, Alicante, SPAIN,

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B. Guyer1, S. Shimamoto1, A. Bradhurst1, E. Grossbard2, S. Dreskin3, H. Nelson4; 1National Jewish Medical and Research Center, Denver, CO, 2Rigel Inc., San Francisco, CA, 3University of Colorado Health Sciences, Denver, CO, 4National Jewish Medical and Research Center and University of Colorado Health Sciences, Denver, CO. Pretreatment With Lidocaine Does Not Inhibit the Maxillary Sinus Eosinophilic Response After Nasal Allergen Challenge F. M. Baroody1, S. Mucha2, M. Detineo2, R. M. Naclerio2; 1Surgery and Pediatrics, University of Chicago, Chicago, IL, 2Surgery, University of Chicago, Chicago, IL. Effect of Desloratadine on the Augmented Bacterial and Inflammatory Response in the Sinuses of Infected Mice V. Kirtsreesakul; Ohns, University of Chicago, Chicago, IL. Expression of Prostaglandin D Synthase and the Prostaglandin D2 Receptors DP and CRTH2 in Human Nasal Mucosa F. G. Gervais1, F. Nantel1, C. Fong1, S. Lamontagne1, D. H. Wright1, A. Giaid2, M. Desrosiers3, K. M. Metters1, G. P. O’Neill1; 1Biochemistry and Molecular Biology, Merck Frosst, Kirkland, PQ, CANADA, 2Montreal General Hospital, Montreal, PQ, CANADA, 3Nasal Physiology Laboratory, Hotel-Dieu de Montreal, Montreal, PQ, CANADA. In Vitro Diagnosis of Chronic Nasal Inflammation M. F. Kramer1, G. Burow2, E. Pfrogner1, G. Rasp1; 1Otorhinolaryngology, Head and Neck Surgery; Ludwig-Maximilians-University, Munich, GERMANY, 2Pharmacia Diagnostics, Freiburg, GERMANY. Effects of Single or Combined Mediator Antagonism on Nasal Adenosine Monophosphate Challenge in Perennial Allergic Rhinitis P. C. Reid, D. K. C. Lee, P. C. Soutar, C. M. Jackson, B. J. Lipworth; Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UNITED KINGDOM. The Effect of Fexofenadine on Expression of Intercellular Adhesion Molecule 1 and Induction of Apoptosis on Peripheral Eosinophils M. Failla, C. Vancheri, C. Mastruzzo, V. Tomaselli, G. Bellistrì, M. Pistorio, L. Greco, E. Trovato Salinaro, M. Contrafatto, N. Crimi; Allergy and Clinical Immunology Operative Unit, Department of Internal and Specialistic Medicine, Catania, ITALY. Association Between Cytokine Responses and Frequency of Common Cold Episodes D. Skoner1, D. Gentile1, B. Angelini1, A. Patel1, H. Richards1, H. Mizoguchi2, W. Doyle3; 1Department of Pediatrics, Allegheny General Hospital, Pittsburgh, PA, 2Proctor and Gamble, Cincinnati, OH, 3University of Pittsburgh, Pittsburgh, PA. Expression and Distribution of the Prostaglandin E2 (PGE2) Receptors EP1, EP2, EP3, and EP4 in Aspirin-Sensitive Rhinosinusitis and Controls Q. Meng1, K. Mallett1, G. Scadding2, A. Parikh2, T. Lee1, C. Corrigan1; 1Department of Asthma, Allergy & Respiratory Medicine, Guy’s, King’s & St Thomas Medical School, London, UNITED KINGDOM, 2Royal National Throat, Nose and Ear Hospital, London, UNITED KINGDOM. Gene Expression for NGF and NGF-Receptors in the Nasal Mucosa of Allergic Rhinitic and Control Subjects A. Tarun, D. Shusterman; Occupational and Environmental Medicine, University of California, San Francisco, San Francisco, CA. The Results of Nasal Provocation Test Do Not Correlate With the sIgE Level, Skin Prick Tests, and Seasonal Symptoms in Children Suffering From Allergic Rhinitis and/or Asthma Hypersensitive to Alternaria tenuis M. Kupczyk, J. Kaczmarek, I. Kuprys´, P. Górski, P. Kuna; Dept of Pneumonology and Allergy, Medical University of Lodz, Lodz, POLAND.

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27A Effectiveness of Azelastine Nasal Spray in Patients With a History of Intranasal Steroid Use M. A. Kaliner; Institute for Asthma and Allergy, Wheaton, MD.

Poster Session 2402 Saturday, March 20 11:00 AM to 12:00 PM Advances in Asthma Treatment 28 (S,S)-Formoterol Increases the Production of IL-4 in Mast Cells and the Airways of a Murine Asthma Model C. K. Oh, D. Abraha, J. M. Park, S. H. Cho; Pediatrics, HarborUCLA, Torrance, CA. 29 In Vitro Comparison of an Electronic Micropump Nebulizer With Other High Efficiency Nebulizers R. Simmons, P. Kakade, J. Fink, P. Uster; Aerogen, Inc., Mountain View, CA. 30 Impact of Racemic Albuterol Compared to Levalbuterol on Objective Measures of Hyperactivity and Inattentiveness in Children With Asthma W. Andrews1, M. H. Teicher2,3, A. Polcari2,3, M. Pankratrz1; 1Medical Affairs, Sepracor, Marlborough, MA, 2Dept of Psychiatry, Harvard Medical School, Boston, MA, 3Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, MA. 31 Blowby vs Face Mask for Nebulized Drugs in Young Children D. E. Geller, B. Kesser; Aerosol Research Laboratory, The Nemours Children’s Clinic, Orlando, FL. 32 Effect of Levalbuterol on Exhaled Nitric Oxide (NO) Levels in Asthmatic Subjects R. Otte1, D. Gentile2, B. Angelini2, J. Krahnke2, H. Richards2, J. Trecki2, W. Doyle1, D. Skoner2; 1Children’s Hospital of Pittsburgh, Pittsburgh, PA, 2Allegheny General Hospital, Pittsburgh, PA. 33 Development of a Novel Bronchoscopic Therapy for Asthma G. Cox1, J. Miller1, C. Danek2, A. Leff3, S. Lam4; 1St. Joseph’s Healthcare, McMaster University, Hamilton, ON, CANADA, 2Broncus Technologies Inc, Mountain View, CA, 3University of Chicago, Chicago, IL, 4Vancouver General Hospital, University of British Columbia, Vancouver, BC, CANADA. 34 Usefulness of a β2-Agonist Patch in the Long-Term Management of Childhood Asthma S. Yoshihara, Y. Yamada, T. Abe, O. Arisaka; Dokkyo University School of Medicine, Mibu, Tochigi, JAPAN. 35 Montelukast Sodium Increased IL-10 Production by Peripheral Blood Mononuclear Cells (PBMC) I. Stelmach1, P. Majak1, A. Sobocinska1, W. Stelmach2, P. Kuna3; 1Pediatrics and Allergy, M Curie Hospital, Zgierz, POLAND, 2Regional Health Authority, Lodz, POLAND, 3Dep. of Allergy and Pneumonology, Medical University, Lodz, POLAND. 36 Post-Exercise Response to Albuterol After Addition of Montelukast or Salmeterol to Inhaled Fluticasone L. Hendeles1, T. A. Erb2, S. Bird2, C. M. Hustad2, J. M. Edelman2; 1Pharmacy and Pediatrics, University of Florida, Gainesville, FL, 2Merck & Co., Inc, West Point, PA. 37 Retrospective Review of Studies Shows That Patients Receiving Salmeterol Plus an ICS Have Fewer Serious Asthma Exacerbations Versus Patients on an ICS Alone, Regardless of Ethnic Origin S. Yancey, B. Prillaman, P. Dorinsky; GlaxoSmithKline, Research Triangle Park, NC. 38 Formoterol Fumarate Inhalation Powder vs Albuterol Inhalation for Treatment of Asthma in the Acute Setting Y. Ogawa1, V. Chou2, N. Sharma2, L. Kalum2, M. Lee-Wong2; 1Division of Allergy and Immunology, Beth Israel Medical Center, New York, NY, 2Medicine, Beth Israel Medical Center, New York, NY.

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T-Cell Apoptotis Induced by Cysteinyl Leukotriene Receptor (CysLT-R) Antagonist Montelukast Occur Trough p53-Dependent Pathway F. Spinozzi1, E. Agea1, A. M. Russano1, S. Piattoni1, F. M. De Benedictis2; 1Internal Medicine, University of Perugia, Perugia, ITALY, 2Pediatrics, Ospedale Salesi, Ancona, ITALY. Which Is More Steroid Sparing in Persistent Bronchial Asthma? Montelukast or Theophylline A. R. Shah; B.J. Medical College, Ahmedabad, INDIA. Cross-Tolerance to Albuterol Occurs Independently of β2Adrenoceptor Genotype-16 in Asthmatic Patients Receiving Regular Formoterol or Salmeterol B. J. Lipworth, D. K. C. Lee, C. E. Bates, C. M. Jackson; Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UNITED KINGDOM. Montelukast Protects Against Nasal Lysine-Aspirin Challenge in Patients With Aspirin-Induced Asthma K. Haggart, D. K. C. Lee, F. M. Robb, B. J. Lipworth; Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UNITED KINGDOM. Single and Chronic Dosing Effects of Levocetirizine on Adenosine Monophosphate Bronchoprovocation in Atopic Asthma D. K. C. Lee, R. D. Gray, F. M. Robb, P. C. Soutar, A. M. Wilson, B. J. Lipworth; Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UNITED KINGDOM. Butterbur, an Herbal Remedy, Confers Complementary Antiinflammatory Activity in Asthmatic Patients Receiving Inhaled Corticosteroids F. M. Robb, D. K. C. Lee, K. Haggart, B. J. Lipworth; Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UNITED KINGDOM. Mechanisms of Action of Nebulized Low-Molecular-Weight Heparin in Patients With Bronchial Asthma A. M. Fal, M. Kraus-Filarska, J. Miecielica, J. Malolepszy; Dept. of Allergology, Wroclaw Medical University, Wroclaw, POLAND. Omalizumab Is Effective in Reducing Asthma Exacerbations Irrespective of Concomitant Long-Acting Beta2-Agonist Use J. Corren1, S. Hedgecock2, G. Ayre2, Y. Deniz3; 1Allergy Research Foundation, Inc., Los Angeles, CA, 2Novartis Horsham Research Centre, Horsham, UNITED KINGDOM, 3Genentech, South San Francisco, CA. Identification of Patients With Irreversible Asthma P. Gupta, P. A. Greenberger; Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL. Efficacy of Omalizumab, an Anti-IgE Antibody, in Patients With Concomitant Moderate-Severe Allergic Asthma and Persistent Allergic Rhinitis R. Dahl1, J. Ayres2, S. Hedgecock3, M. Blogg3, K. Surrey3, H. Fox3; 1Department of Respiratory Diseases and Allergology, University Hospital Aarhus, Aarhus, DENMARK, 2Department of Environmental and Occupational Medicine, Liberty Safe Work Research Centre, Aberdeen, UNITED KINGDOM, 3Clinical Development, Novartis Horsham Research Centre, Horsham, UNITED KINGDOM. Control of T-Cell Responses by the Combination of Low Dose Steroids With Beta2-Agonists A. Dunlap, E. Goleva, D. Y. M. Leung; Department of Pediatrics, National Jewish Medical & Research Center, Denver, CO. Benefits of a School-Based Asthma Treatment Program in the Absence of Secondhand Smoke Exposure R. J. Holzhauer1,2, J. S. Halterman1, P. G. Szilagyi1, H. L. Yoos3, K. M. Conn1, J. M. Kaczorowski1, S. C. Lauver4, T. L. Neely5, P. M. Callahan5, K. M. McConnochie1; 1Pediatrics, University of Rochester School of Medicine, Rochester, NY, 2Allergy Asthma

Immunology of Rochester, Rochester, NY, 3Nursing, University of Rochester School of Medicine, Rochester, NY, 4Center for Governmental Research, Washington, DC, 5University of Rochester, Rochester, NY. 50A Ciclesonide Is Well Tolerated and Has Minimal Oropharyngeal Side Effects at Once-Daily Doses of 80 µg, 160 µg, and 320 µg in the Treatment of Patients With Mild-to-Moderate Asthma W. E. Berger1, L. Mansfield2, C. Pinter3, J. Fish3, S. Kundu3, J. Williams3, D. Banerji, P. Hamedani3; 1Southern California Research, Mission Viejo, CA; 2El Paso Institute for Medical Research Development, El Paso, TX; 3Aventis, Bridgewater, NJ. 50B The Correlation of Cockroach and Dust Mite Specific IgE Levels and Medication Requirements Among Inner-City Asthmatic Children K. M. Schroederus1,2, H. Kaymakcalan2, J. Moy1,2, B. Yu1,2; 1Immunology/Microbiology, Rush Medical College, Chicago, IL, 2Pediatric Allergy/Immunology, Cook County Hospital, Chicago, IL.

Poster Session 2403 Saturday, March 20 11:00 AM to 12:00 PM Immunodeficiency I 51 Switched Memory B Cells in Common Variable Immunodeficiency J. Ko, L. Radigan, C. Cunningham-Rundles; Allergy and Immunology, Mount Sinai Medical Center, New York, NY. 52 An Epidemiological Comparative Analysis of CVID Patients With or Without Lung Damage D. Naimi, H. Tcheurekdjian, R. W. Hostoffer, Jr.; Pediatrics, Case Western Reserve University, Cleveland, OH. 53 The Immunologic Deficiency of Rubinstein-Taybi Syndrome F. Wertheimer1, D. Naimi2, J. Munoz3, L. Severidt4, J. Rubinstein5, R. W. Hostoffer, Jr.2; 1Ohio University College of Osteopathic Mediciene, Athens, OH, 2Pediatrics, Case Western Reserve University, Cleveland, OH, 3Pediatric, New York Medical College, Valhalla, NY, 4Pediatrics, Pella Regional Health Center, Pella, IA, 5Pediatrics, University of Cincinnati, Cincinnati, OH. 54 Cellular Immunity in Patients With Partial DiGeorge Syndrome Who Have Received Live Viral Vaccines A. N. Wasan, L. M. Noroski, W. T. Shearer, E. H. Moylett; Allergy/Immunology, Baylor College of Medicine, Houston, TX. 55 Response of Live Vaccines Administered to Clinically Immunocompetent Patients With a 22q11.2 Chromosomal Microdeletion O. M. Chen, C. F. Remer, B. J. Goldberg, A. M. Staveren, C. K. E. Lin, M. S. Kaplan; Allergy and Clinical Immunology, Kaiser Los Angeles Medical Center, Los Angeles, CA. 56 Common Variable Immunodeficiency in Children: Clinical and Immunological Features of Patients Diagnosed Before the Age of 13 E. J. Vukic1, C. Cunningham-Rundles2; 1Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY, 2Divison of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY. 57 Immune Response in Ring Chromosome 18 A. K. Sue-A-Quan1, R. S. Kagan2, B. D. Mazer2; 1Allergy & Clinical Immunology, McMaster University, Hamilton, ON, CANADA, 2Pediatrics, McGill University, Montreal, PQ, CANADA. 58 A Novel Termination Codon Mutation of the WAS Gene in a Thai Family With Wiskott-Aldrich Syndrome A. Chewataworn1, P. Chatchatee1, C. Srichomthong2, J. Ngamphaiboon1, V. Shotelersuk2; 1Division of Allergy and Immunology, Department of Pediatrics, Chulalongkorn University, Bangkok,

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THAILAND, 2Division of Medical Genetics and Metabolism, Department of Pediatrics, Chulalongkorn University, Bangkok, THAILAND. Sarcoidosis in 3 Adolescent Patients With Digeorge Syndrome P. N. Rancitelli1, P. J. Dowling2, J. D. Jacobson2, M. I. Grijnsztein3, V. R. Bonagura3, A. A. Hamed4, M. L. Markert1; 1Pediatrics, Duke University Medical Center, Durham, NC, 2Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, 3Pediatrics, North Shore-Long Island Jewish Health System, New Hyde Park, NY, 4Pediatrics, Memorial University of Newfoundland, St. John’s, NF, CANADA. Primary Antibody Immunodeficiency in Children: Clinical Presentation and Outcome M. Dow, P. D. Arkwright; Child Health, University of Manchester, Manchester, UNITED KINGDOM. Defects in CD27+ Memory B Cells and CCR4+ T Cells Occurring in Association With Elevated Serum Epstein-Barr Virus (EBV) Loads in XLP Patients Surviving Primary EBV Infection A. Malbran1, L. Belmonte2, B. Ruibal-Ares2, P. Bare2, K. E. Nichols3, M. M. Bracco2; 1Allergy and Immunology, Hospital Britanico de Buenos Aires, Buenos Aires, ARGENTINA, 2Immunology, Instituto de Investigaciones Hematologicas, Buenos Aires, ARGENTINA, 3Children’s Hospital of Philadelphia, Philadelphia, PA. Common Variable Immunodeficiency in Children. Cases Review M. D. Zárate-Hernández1, J. El-Haken-García2, M. HernándezGonzález2, A. Arias-Cruz1, S. N. González-Díaz1, T. Español2; 1Allergy and Clinical Immunology, University Hospital, Monterrey, MEXICO, 2Immunology, Vall d’Hebron Hospital, Barcelona, SPAIN. Transient Hypogammaglobulinemia of Infancy; Analysis and Follow-up M. A. Whelan1, W. H. Hwan1, S. J. McGeady2, J. Beausoleil3; 1Allergy/Immunology, Thomas Jefferson, Philadelphia, PA, 2Allergy/Immunology, AI duPont, Wilmington, DE, 3Allergy/Immunology, Children’s Hospital of Pennsylvania, Philadelphia, PA. Selective Abnormal Response to Streptococcus pneumoniae Heptavalent Conjugate Vaccine in Patients With Recurrent Infections and Normal Immunoglobulin Concentrations V. Moschese1, C. Capponi2, L. Chini1, L. Nicolosi3, F. Angelini1, M. Chianca1, E. Freda1, P. Ciaffi2, P. Rossi1,2; 1Dept of Pediatrics, Tor Vergata University, Rome, ITALY, 2Div. of Immunoinfectivology, Children’s Hospital Bambino Gesù, Rome, ITALY, 3Infectious Disease Unit, Children’s Hospital Bambino Gesù, Rome, ITALY. Intracellular Cytokine Production by T Cells in SCID Infants With Time Post-Bone Marrow Transplantation (BMT) E. O. Sajaroff, R. H. Buckley; Pediatrics & Immunology, Duke University Medical Center, Durham, NC. Subcutaneous Immunoglobulin Infusions for Treatment of a Child With Severe Protein-Losing Enteropathy J. H. Lin, R. L. Roberts; Division of Pediatric Allergy, Immunology, Rheumatology, UCLA, Los Angeles, CA. The General Characteristics of Our Patients With Primer Immunodeficiency M. Yilmaz, S. G. Kendirli, D. U. Altıntas, G. B. Karakoc; Pediatric Allergy and Immunology, Cukurova University, Adana, TURKEY. Gamma Radiation-Induced Human B Cell Defects: Model for Space Flight C. L. Nance1, W. T. Shearer1,2; 1Allergy/Immunology, Texas Children’s Hospital, Houston, TX, 2Dept. Pediatrics, Baylor College of Medicine, Houston, TX. Unresponsiveness to Conjugate Pneumococcal Polysaccharides in Children With Recurrent Respiratory Infections E. J. Saturno1, K. E. Mason2, L. Leiva1, R. U. Sorensen1; 1Pedi-

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atrics, Division of A/I, LSU Health Sciences Center, New Orleans, LA, 2School of Public Health, LSU Health Sciences Center, New Orleans, LA. Immune Thrombocytopenic Purpura (ITP) and Autoimmune Hemolytic Anemia (AHA) in Patients With Combined Variable Immunodeficiency (CVID) J. Wang1, C. Cunningham-Rundles2; 1Division of Allergy and Clinical Immunology, Mount Sinai School of Medicine, New York, NY, 2Division of Clinical Immunology, Mount Sinai School of Medicine, New York, NY. IgG Replacement by the Subcutaneous Route Using Preparations Licensed in the USA for Administration by Other Routes K. A. Duff1, S. Roy2, J. Poll2, M. Berger2; 1Allergy and Immunology, Case Western Reserve University, University Hospitals of Cleveland/Rainbow Babies and Childrens’ Hospital, Cleveland, OH, 2Allergy and Immunology, Case Western Reserve University, University Hospitals of Cleveland/Rainbow Babies and Childrens’ Hospital, Cleveland, OH. Characteristics and Health Outcomes of Patients With Primary Immune Deficiency Diseases in the United States J. Boyle; Immune Deficiency Foundation, Towson, MD. Successful HLA-Identical Bone Marrow Transplantation in a Patient With Interferon-γ Receptor 2 Deficiency and Disseminated Mycobacterium Avium Complex Infection A. M. Scurlock1, E. O. Sajaroff1, S. D. Rosenzweig2, P. L. Martin3, S. M. Holland2, R. H. Buckley1; 1Division of Pediatric Allergy and Immunology, Duke University Medical Center, Durham, NC, 2National Institutes of Health, Bethesda, MD, 3Duke University Medical Center, Durham, NC. A Case of Bare Lymphocyte Syndrome J. A. Flemming, G. Lacuesta; Dalhousie University Medical School, Halifax, NS, CANADA. Missense Mutation in Btk Exon 15 Results in Variant X-Linked Agammaglobulinemia (XLA) With Mild Clinical Phenotype H. M. Rosenblatt1,2, M. E. Paul1,2, H. Ochs3, C. Davis2, M. Coyne2, W. Lee3; 1Pediatrics, Baylor College of Medicine, Houston, TX, 2Texas Children’s Hospital, Houston, TX, 3Pediatrics, University of Washington, Seattle, WA. Single Mutation in the Cystic Fibrosis Transmembrane Regulatory Gene in Patients With Chronic Sinusitis and Hypogammaglobulinemia: A Novel Immunodeficiency A. Smith1, F. Accurso2, I. Melamed1; 11st Allergy and Asthma Clinical Research, Englewood, CO, 2Pulmonary, Children’s Hospital, Denver, CO. A Kindred With a Non-WASP-Associated Wiskott-Aldrich Syndrome Variant Characterized by Mental Impairment and Dominant Inheritance S. M. Sheikh1, H. W. Schroeder, Jr.2; 1Pediatrics, Division of Allergy & Immunology, University of Alabama at Birmingham, Birmingham, AL, 2Medicine, Microbiology & Genetics, University of Alabama at Birmingham, Birmingham, AL. Description of a Cohort of Patients With Selective Polysaccharide Antibody Deficiency A. Madaan1, K. Drain2, A. Vaishnav3, D. Lowe4, R. Ten5, C. R. Weiler1; 1Division of Allergic Diseases, Mayo Clinic, Rochester, MN, 2Spokane Allergy & Asthma Clinic, Spokane, WA, 3Johns Hopkins Asthma & Allergy Center, Baltimore, MD, 4Olmsted Medical Center, Rochester, MN, 5Section of Pediatric Pulmonary, Critical Care & Allergy, Indiana University School of Medicine, Indianapolis, IN. Preclinical Characterization of a New Liquid “Immune Globulin Intravenous (Human), 10% Triple Virally Reduced Solution” (IGIV, 10%TVR) W. Teschner, IV1, W. Auer2, L. Pichler3, U. Bölzlbauer4, A. Butterweck1, H. Schwarz5; 1Product and Process Development Immunoglobulin/Albumin, Baxter BioScience, Vienna, AUSTRIA,

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2Toxicology, Baxter BioScience, Vienna, AUSTRIA, 3Pharmacology, Toxicology and Preclinicals, Baxter BioScience, Vienna, AUSTRIA, 4Product and Process Development Immunology/Albumin, Baxter BioScience, Vienna, AUSTRIA, 5Global Preclinical R&D, BioPharmaceuticals, Baxter BioScience, Vienna, AUSTRIA. Skeletal Anomalies in Hyper-IgE Recurrent Infection Syndrome (HIES, Job Syndrome) J. Chinen1, J. Davis1, D. Darnell2, B. Hay1, S. Hill3, S. M. Holland2, J. M. Puck1; 1Genetics and Molecular Biology Branch, NHGRI, NIH, DHHS, Bethesda, MD, 2Laboratory of Host Defenses, NIAID, NIH, DHHS, Bethesda, MD, 3Diagnostic Radiology Department, Clinical Center, NIH, DHHS, Bethesda, MD. Longstanding Common Variable Immunodeficiency (CVID) Sans Recurrent Sinopulmonary Infection M. C. Glaum, D. F. LaRosa, A. J. Apter, A. I. Levinson; Allergy and Clinical Immunology, Hospital of the University of Pennsylvania, Philadelphia, PA. Clinical and Immunologic Features of 24 Patients With Transient Hypogammaglobulinemia of Infancy M. J. Dorsey, J. S. Orange; Immunology, Children’s Hospital Boston, Boston, MA. Evidence of Thymic Dysfunction in Ataxia Telagiectasia D. D. Siri, N. -. Tangsinmankong; Pediatrics, University of South Florida - ACH, Saint Petersburg, FL. Diagnosis of Primary Immunodeficiency; Can Review of Medical History Help? H. Yarmohammadi, L. Estrella, C. Cunningham-Rundles; Mt Sinai Hospital, New York City, NY. Impaired Regulation of Immune Cells With Low Doses of Radiation Exposure: Possible Connection to Allergy Development L. Titov1, D. Charnashey1, E. Kirylchyk1, P. Rytik1, L. M. DuBuske2, H. C. Schroder3, W. Muller3; 1RIEM, Minsk, BELARUS, 2Immunology Research Institute of New England, Fitchburg, MA, 3Institute for Physiologische Chemie, Mainz, GERMANY.

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2404 Saturday, March 20 11:00 AM to 12:00 PM Innate and Adaptive Immunity 86 The Effect of Human Beta-Defensin 2 on Innate Immunity of CaCo-2 Colonic and MCF-7 Breast Epithelial Cells N. Stroinigg1, M. Srivastava2; 1Miami University, Oxford, OH, 2Metrohealth Medical Center, Cleveland, OH. 87 Modulation and Function of Progesterone Induced Blocking Factor (PIBF) in U937 and T-PLL Cell Lines A. Thomas1, M. D. Srivastava1, J. H. Check2, J. Szekeres-Bartho3; 1Pediatrics, Case Western Reserve University, Cleveland, OH, 2Obstetrics and Gynecology, Robert Wood Johnson Medical School, Camden, NJ, 3Department of Medical Microbiology and Immunology, Medical School at Pecs University, Pecs, HUNGARY. 88 Peanut-Specific B and T Cell Responses Are Correlated in Peanut Allergic Individuals Whereas Tetanus-Specific B and T Cell Responses Are Not V. H. Turcanu1, M. Winterbotham2, P. Kelleher2, G. Lack1; 1Paediatrics, Imperial College London, London, UNITED KINGDOM, 2Clinical Immunology, Imperial College London, London, UNITED KINGDOM. 89 Costimulatory Signal Confers Steroid Resistance on Human Helper T Cells A. Mori, T. Hashimoto, K. Akiyama; Clinical Research Center, National Sagamihara Hospital, Sagamihara, JAPAN.

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Consolidation Of Der p 1-Specific Antibody Responses in Atopic and Non-Atopic Infants D. R. Jackola1, C. L. Liebeler1, C. Lin2, Y. Chai2, M. N. Blumenthal1; 1Medicine/Allergy, University of Minnesota, Minneapolis, MN, 2Pediatrics, Changua Christian Hospital, Changua, TAIWAN REPUBLIC OF CHINA. Production of IFN-α by Human and Murine Mast Cells Induced by Double-Stranded RNA: Evidence for Activation Through Toll-like Receptor-3 (TLR-3) M. Kulka1, B. Kelsall2, H. Rosenberg3, L. Alexopoulou4, R. Flavell4, D. Metcalfe1; 1Laboratory of Allergic Diseases, NIH/NIAID, Bethesda, MD, 2Laboratory of Clinical Investigation, NIH/NIAID, Bethesda, MD, 3Laboratory of Host Defenses, NIH/NIAID, Bethesda, MD, 4Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT. Polarization of Chemokine Receptor Expression in Human Peripheral Blood and Bronchoalveolar T Cells A. J. Morgan, F. A. Symon, M. A. Berry, C. E. Brightling, A. J. Wardlaw; Respiratory Medicine, Institute for Lung Health, Leicester, UNITED KINGDOM. Assessment of the Association Between Measles Vaccine Response and Asthma Status Y. J. Juhn1, H. Kita1, M. F. DeBolt1, G. A. Poland2, S. V. Pankratz3, R. M. Jacobson1; 1Pediatric and Adolescent Med., Mayo Clinic, Rochester, MN, 2Internal Medicine, Mayo Clinic, Rochester, MN, 3Heaslth Science Research, Mayo Clinic, Rochester, MN. Chemokine CCL5 Signals Required for Survival During Viral Infection J. W. Tyner1, O. Uchida1, N. Kajiwara1, E. Y. Kim1, M. P. O’Sullivan1, M. J. Walter1, D. N. Cook2, T. M. Danoff3, M. J. Holtzman1; 1Medicine and Cell Biology, Washington University, St. Louis, MO, 2Medicine, Duke University, Durham, NC, 3Medicine, University of Pennsylvania, Philadelphia, PA. The Macrophage Mannose Receptor (MMR) and Toll-like Receptor 2 (TLR2) and 4 (TLR 4) in Chronic Sinus Disease S. E. M. Claeys; Ent, University Hospital, Gent, BELGIUM. Development of a Whole Blood Stimulation Assay to Assess TLR-Dependent Innate Immune Responses C. W. Thurm, S. Manna, J. F. Halsey; IBT Reference Laboratory, Lenexa, KS. B Cell Priming In Utero to Influenza Vaccination D. Rastogi1, Y. Ogawa2, C. Lendor3, D. Blythe4, R. L. Miller1; 1Devision of Pulmonary, Allergy, Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NY, 2Medicine, Beth Israel Medical Center, New York, NY, 3Devision of Allergy, Pulmonary, Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NY, 4Devision of Pulmonary, Allergy, Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NY. De Novo Generation of T cells Against Viruses Present in the Body During Immune Reconstitution J. Storek, T. Kalina, H. Lu, H. Kiem; University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA. IL-7 Improves Reconstitution of CD4 T Cells, Including Cytomegalovirus-Specific CD4 T Cells, in Lymphopenic Monkeys J. Storek, H. Lu, T. Kalina, H. Kiem; University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA. T Cell Depletion in Wolf-Hirschhorn Syndrome D. M. Zacharias1, N. Tangsinmankong2; 1Department of Pediatrics, University of South Florida/All Children’s Hospital, St. Petersburg, FL, 2University of South Florida/All Children’s Hospital, St. Petersburg, FL.

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The Interaction of Lysozyme and Glycosaminoglycans: An Element of the Intrinsic Immune System A. S. Josephson; Department of Medicine, State University of New York, Brooklyn, NY. Differential Involvement of Adaptor Molecules in Individual TLR Signalings S. Akira; Department of Host Defense, Osaka University, Research Institute for Microbial Diseases, Suita, Osaka, JAPAN. Differential Effects of Fluticasone Propionate (FP) on Gene Expression in Airway Epithelial cells Q. Sha, A. Troung-Tran, R. P. Schleimer; Johns Hopkins Asthma and Allergy Center, Baltimore, MD. Nitration Immunology A. F. Smith, S. Samee, J. W. Vaughan, J. F. Hunt; Pediatric & Respiratory Medicine, University of Virginia, Charlottesville, VA. Increased Propensity of Atopic Dermatitis (AD) Patients to Viral Infections May Be Due to Th2 Cytokines Which DownRegulate Cathelicidins With Anti-Viral Activity M. D. Howell1, J. E. Streib1, K. O. Kisich1, J. F. Jones2, R. L. Gallo3, D. Y. M. Leung1; 1Department of Pediatrics, National Jewish Medical & Research Center, Denver, CO, 2Centers for Disease Control, Atlanta, GA, 3Department of Dermatology, Veterans Hospital of San Diego, San Diego, CA. Toll-like Receptors and Control of Mammalian Immunity R. Medzhitov, R. Medzhitov; Section of Immunobiology, Yale University School of Medicine, New Haven, CT. The Mature Activating Natural Killer Cell Immunologic Synapse Is Formed in Distinct Stages J. S. Orange1, R. S. Geha2, J. L. Strominger3; 1Immunology, Children’s Hospital of Philadelphia - University of Pennsylvania School of Medicine, Philadelphia, PA, 2Immunology, Children’s Hospital Boston - Harvard Medical School, Boston, MA, 3Molecular and Cellular Biology, Harvard University, Cambridge, MA. Declining Cell-Mediated Immunity Is Associated With Increased Chronic Disease Burden A. W. Rafi, W. W. Crawford, W. B. Klaustermeyer; Division of Allergy and Immunology, Veterans Affairs Greater Los Angeles Healthcare System, The David Geffen School of Medicine at UCLA, Los Angeles, CA. Airway Epithelial Cells Express Toll-like Receptor 3 and Its Ligand Stimulates Inflammatory Cytokines and Chemokines Through NF-kB and IRF3 S. Matsukura1, F. Kokubu1, M. Kawaguchi1, K. Ieki1, M. Kurokawa1, S. Suzuki1, M. Odaka1, S. Watanabe1, M. Adachi1, R. P. Schleimer2; 1First Department of Internal Medicine, Showa University School of Medicine, Tokyo, JAPAN, 2Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Baltimore, MD. Different Requirements for CD40-DC154 Interaction During Thymic Negative Selection of CD4+ T Cells Z. Nayak, J. Hegde, L. Vogel; Department of Biological Sciences, Illinois State University, Normal, IL. Expression of IL13 Receptor Alpha 1 in Human B Cells Committed to Produce IgE H. Zheng1, O. Hajoui1, L. M. Fawaz1, B. D. Mazer1,2; 1Meakins Christie Laboratories, McGill University, Montreal, PQ, CANADA, 2Montreal Children’s Hospital, Montreal, PQ, CANADA. Unique Culture System for Investigation of Human B-Lymphocyte Colonies B. D. Mazer1, H. Zheng2; 1Montreal Children’s Hospital, Montreal, PQ, CANADA, 2Meakins Christie Laboratories, McGill University, Montreal, PQ, CANADA. Distantly Related Members of T Cell Co-stimulatory Pathways M. J. Butte1, A. H. Sharpe2, R. S. Geha1; 1Division of Immunology, Children’s Hospital Boston, Boston, MA, 2Department of Pathology, Brigham and Women’s Hospital, Boston, MA. Signaling of Human B Cells Via Toll-like Receptors 7 and 8

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Modulates Immunoglobulin Production J. Lynn, M. C. Glaum, A. I. Levinson; Allergy and Clinical Immunology, Hospital of the University of Pennsylvania, Philadelphia, PA. The Strength and Duration of Naïve T-Cell Stimulation Directs Their Responsiveness to TGF-β1 B. R. Ludviksson1, S. M. Maggadottir1, B. Gunnlaugsdottir2; 1Department of Immunology, Landspitali - University Hospital, Reykjavík, ICELAND, 2Center for Rheumatology Research, Landspitali - University Hospital, Reykjavík, ICELAND.

Poster Session 2405 Saturday, March 20 11:00 AM to 12:00 PM Inflammatory Mediators in Atopic Dermatitis 116 Distinct Patterns of Chemokine Gene Expression in the Skin Lesions of Atopic Dermatitis and Psoriasis: A Gene Microarray Analysis I. Nomura1, Y. Ohya1, B. Gao2, M. Boguniewicz3, M. A. Darst4, J. B. Travers4, D. Y. M. Leung3; 1Allergy and Immunology, National Center for Child Health and Development, Setagaya-ku, Tokyo, JAPAN, 2Microarray Core Laboratory, University of Colorado Health Sciences Center, Denver, CO, 3Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO, 4Departments of Dermatology, Pediatrics, Indiana University School of Medicine, Indianapolis, IN. 117 Polymorphisms of Cytokine Genes in Atopic Dermatitis A. Sediva1, K. Sismova1, E. Vernerova1, S. Capkova2, O. Cinek3, V. Malinova3; 1Institute of Immunology, Charles University, Prague, CZECH REPUBLIC, 2Department of Dermatovenereology, Charles University, Prague, CZECH REPUBLIC, 3Pediatric Clinic, Charles University, Prague, CZECH REPUBLIC. 118 Expression Analysis of Macrophage-Derived Chemokine (MDC/CCL22) Gene in Canine Atopic Dermatitis T. Tsukui1, S. Maeda2, K. Ohmori2, K. Masuda2, K. Ohno2, M. Sakaguchi3, H. Tsujimoto2, S. Iwabuchi1; 1Central Recearch Laboratories, NIPPON ZENYAKU KOGYO CO., LTD., Koriyama, Fukushima, JAPAN, 2Department of Veterinary Internal Medicine, The University of Tokyo, Tokyo, JAPAN, 3Department of Immunology, National Institute of Infectious Diseases, Tokyo, JAPAN. 119 Evaluation of Cytokine Production, Activation Marker and Homing Receptors in Children With Atopic Dermatitis and Atopic Bronchial Asthma C. Antunez1, M. J. Torres2, C. Mayorga1, J. L. Corzo3, A. Vera4, J. A. Cornejo-Garcia1, A. Jurado3, M. Blanca2; 1Research Laboratory, Carlos Haya Hospital, Málaga, SPAIN, 2Allergy Service, Carlos Haya Hospital, Málaga, SPAIN, 3Allergy Pediatric Unit, Carlos Haya Hospital, Málaga, SPAIN, 4Dermatology Service, Carlos Haya Hospital, Málaga, SPAIN. 120 Modulation of Chemokine Receptor Expression on CLA+ T Cells in Atopic Dermatitis S. L. Seneviratne, A. Black, L. Jones, R. Chakraborthy, A. King, S. Powell, A. J. McMichael, G. S. Ogg; Molecular Immunology Group, Weatherall Institute of Molecular Medicine, Oxford, UNITED KINGDOM. 121 Study of Urinary Leukotriene E4 and Serum Eosinophil Cationic Protein in Children With Atopic Dermatitis and Their Correlation With Disease Activity J. Oh1, H. Lee2; 1Pediatrics, Hanyang University Hospital, Guri, Kyunggi-Do, REPUBLIC OF KOREA, 2Pediatrics, Hanyang University Hospital, Seoul, REPUBLIC OF KOREA. 122 Urinary Eosinophilic Protein X (U-EPX) and Prediction of Development of Atopy and Atopic Dermatitis

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C. Gore1, C. G. B. Peterson2, A. Simpson1, B. M. Simpson1, P. Kissen1, A. Woodcock1, A. Custovic1; 1North West Lung Research Centre, Wythenshawe Hospital, Manchester, UNITED KINGDOM, 2Pharmacia Diagnostics, Uppsala, SWEDEN. Enhanced Reactive Oxygen Species Formation by Peripheral Blood Mononuclear Cells, Not by Polymorphonuclear Leukocytes, in Atopic Dermatitis J. T. Kim1, S. W. Kim2, H. H. Kim3, M. H. Lee3, J. S. Lee3; 1Catholic University Medical College, Uijongbu-city, REPUBLIC OF KOREA, 2St. Benedict Hospital, Busan, REPUBLIC OF KOREA, 3Catholic University Medical College, Seoul, REPUBLIC OF KOREA. Altered Lipid Cell Membrane Profile in Children Affected by Atopic Dermatitis L. Chini1, F. Angelini1, V. Moschese1, S. Dellonte2, C. Chatgilialoglu2, R. Iannini1, A. Polito1, P. Rossi1,3, C. Ferreri2; 1Dpt of Pediatrics, University of Rome “Tor Vergata”, Rome, ITALY, 2National Council of Research (CNR), I.S.O.F, Bologna, ITALY, 3Dpt of Immunoinfettivology, Children’s Hospital Bambino Gesù, Rome, ITALY. Short Term Exposure to Volatile Organic Compounds Enhances Atopy Patch Test Reaction J. Huss-Marp1, B. Eberlein-Koenig1, U. Darsow2, K. Breuer3, S. Mair3, U. Kraemer1, E. Mayer3, K. Gertis3, J. Ring2, H. Behrendt1; 1Dep. Dermatol. & Allergy Biederstein, TU Munich, Div. Environm. Dermatol & Allergy, GSF/TUM, Munich, GERMANY, 2Dep. Dermatol. & Allergy Biederstein, TU Munich, Munich, GERMANY, 3Fraunhofer Institute for Building Physics IBP, Valley, GERMANY.

Poster Session 2406 Saturday, March 20 11:00 AM to 12:00 PM Mechanisms of Allergic Skin Inflammation 126 Increase of CCR4+ Cells in Peripheral Blood CD4+ Cells in Dogs With Allergic Diseases S. Maeda, K. Ohmori, N. Yasuda, K. Masuda, K. Ohno, H. Tsujimoto; Department of Veterinary Internal Medicine, The University of Tokyo, Tokyo, JAPAN. 127 The Effects of Skin Integrity on Para-Phenylenediamine Hypersensitivity in BALB/c Mice R. Sullivan1, S. Azadi2, B. B. Hayes1, B. J. Meade2; 1University of Tennessee College of Medicine - Chattanooga Unit, Chattanooga, TN, 2NIOSH, Morgantown, WV. 128 Contact Hypersensitivity to Methyl Red in Female Balb/c Mice B. B. Hayes1, S. Azadi2, R. R. Sullivan1, B. J. Meade2; 1University of Tennessee College of Medicine - Chattanooga Unit, Chattanooga, TN, 2NIOSH, Morgantown, WV. 129 The Role of Matrix Metalloproteinase (MMP)-2, MMP-9, and MMP-13 in Bullous Pemphigoid Y. Niimi1, R. Pawankar2, S. Kawana1; 1Dermatology, Nippon Medical School, Tokyo, JAPAN, 2Otolaryngology, Nippon Medical School, Tokyo, JAPAN. 130 Using TRUE Patch Test TM for the Diagnosis of Allergic Contact Dermatitis in China L. Wen, J. Yin; Allergy, Peking Union Medical College Hospital, Beijing, CHINA.

Poster Session 2407 Saturday, March 20 11:00 AM to 12:00 PM Occupational Allergic Disease, Asthma and Latex 131 IPEADAM Study: Indoor Characteristics Predictors of High Endotoxin Exposure G. Tavernier1, G. Fletcher1, G. Blacklock2, A. Watson2, I. Gee2, M. Hazell1, T. Frank1, P. Frank1, A. Pickering1, R. M. L. Niven1; 1North West Lung Research Centre, Wythenshawe Hospital, Manchester, UNITED KINGDOM, 2Atmospheric Research and Information Centre, Manchester Metropolitan University, Manchester, UNITED KINGDOM. 132 Agreement on Smoking Behavior and Asthma Medications Among Rural School Age Children With Asthma, Their Parents and Primary Care Providers (PCPs) K. L. Hill1, C. J. Lewis1, K. Huss2, R. Thompson3, L. LewisBoyer1, T. Brennan-Smith1, A. Butz4, M. Winkelstein1; 1School of Nursing, Johns Hopkins University, Baltimore, MD, 2National Institute of Nursing, National Institutes of Health, Bethesda, MD, 3Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 4School of Medicine, Dept of Pediatrics, Johns Hopkins University, Baltimore, MD. 133 Effect of Preexposure to Endotoxins in Cat Allergic Asthmatics C. Sohy1, F. Lieutier-Colas1, A. Casset1, P. Meyer2, G. Pauli1, F. de Blay1; 1Hôpitaux Universitaires de Strasbourg, Service de Pneumologie, Strasbourg, FRANCE, 2Faculté de Médecine, Service de Biostatistiques et Informatique Médicale, Strasbourg, FRANCE. 134 Health Effects of a Mold-Contaminated Automobile J. Santilli1, W. Rockwell2, W. Vaughan3; 1St. Vincent’s Medical Center, Bridgeport, CT, 2Bridgeport Hospital, Bridgeport, CT, 3Nauset Environmental, Orleans, MA. 135 Clusters of Autoimmune Diseases in Microbial Exposure in Moisture Damaged Buildings T. M. Husman; Department of Environmental Health, National Public Health Institute, Kuopio, FINLAND. 136 The Effect of Smoking on the Serum Concentrations of IgE and Eosinophilic Cationic Protein in Children With Acute Asthma Exacerbation H. Kim, D. Song, J. Choung; Pediatrics, Korea University Medical College Hospital, Seoul, REPUBLIC OF KOREA. 137 Effects of Paternal Tobacco Smoking on Children’s Pulmonary Function D. J. Song, H. J. Kim, J. T. Choung; Department of Pediatrics, Korea University Medical College Hospital, Seoul, REPUBLIC OF KOREA. 138 Challenge Tests With Powder-Free Natural Rubber Latex (NRL) Gloves in Health Care Workers With a History of NRLInduced Asthma H. Allmers1, D. Beezhold2, R. G. Hamilton3, E. R. Sutherland4; 1University of Osnabrueck, Osnabrueck, Nds, GERMANY, 2NIOSH, Morgantown, WV, 3The Johns Hopkins University, Baltimore, MD, 4National Jewish Medical and Research Center, Denver, CO. 139 Causative Agents of Baker’s Asthma: A Clinical and Immunologic Study C. Escudero, S. Quirce, M. Fernández-Nieto, J. Cuesta, M. de las Heras, J. Sastre; Allergy, Fundación Jiménez Díaz, Madrid, SPAIN. 140 A Significant Decrease in the Incidence of Latex-Allergic Health Care Workers Parallels With a Decreasing Percentage of Highly Allergenic Latex Gloves in the Market in Finland T. Reunala1, K. Turjanmaa1, H. Alenius2, H. Reinikka-Railo3, T. Palosuo4; 1Tampere University Hospital, Tampere, FINLAND, 2National Institute of Occupational Health, Helsinki, FINLAND, 3National Agency of Medicines, Helsinki, FINLAND, 4National Institute of Public Health, Helsinki, FINLAND.

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HDI-Specific IgE Antibody Results Are Influenced by Relative Antibody Affinity P. Campo1, Z. L. Lummus1, A. Cartier2, J. Côté3, J. Malo2, L. Boulet3, J. L’Archevéque2, J. Milot3, D. I. Bernstein1; 1Internal Medicine/Division Immunology, University of Cincinnati, Cincinnati, OH, 2Hôpital du Sacré Coeur de Montréal, Montréal, PQ, CANADA, 3Hôpital Laval, Sainte-Foy, PQ, CANADA. Prevalence of Upper and Lower Respiratory Symptoms in Workers Exposed to Colophony and MBTS A. Siracusa1, M. Pace2, C. Tacconi2, A. Silvestrelli3, A. Bussetti1; 1Occupational Allergology, University of Perugia, Terni, ITALY, 2Occupational Medicine and Toxicology, University of Perugia, Perugia, ITALY, 3Occupational Physician, Terni, ITALY. Cutaneous Route Latex Sensitization Followed by Latex Challenge Induces Airway Hyperresponsiveness (AHR) and Th2 Dominated Lung Inflammation in Mice M. Lehto1, R. Haapakoski1, H. Wolff1, M. Majuri1, K. Turjanmaa2, T. Palosuo3, T. Reunala4, H. Alenius1; 1Finnish Institute of Occupational Health, Helsinki, FINLAND, 2University and University Hospital of Tampere, Tampere, FINLAND, 3National Public Health Institute, Helsinki, FINLAND, 4University and University Hospital of Tampere, Tampere, FINLAND. Latex Allergy and Cross-Reactivity to Manioc: Report of 2 Cases C. E. S. Galvao1, L. K. Iwai2, M. E. B. Andrade3, J. Kalil4, F. F. Morato Castro4; 1Clinical Immunology and Allergy Division, University of Sao Paulo Medical School, Sao Paulo, BRAZIL, 2Laboratory of Immunology - Heart Institute, University of Sao Paulo Medical School, Sao Paulo, BRAZIL, 3Allergy and Immunology Division, Hospital do Servidor Estadual, Sao Paulo, BRAZIL, 4Clinical Immunology and Allergy, University of Sao Paulo Medical School, Sao Paulo, BRAZIL. Occupational Rhinitis Due to Pepsin L. Marquès1, S. Lara2, T. Abós2, B. Bartolomé3; 1Allergy Department, Hospital Universitari Arnau de Vilanova, Lleida, SPAIN, 2Allergy Department, Hospital Santa Maria, Lleida, SPAIN, 3R&D Department, Bial-Arístegui, Bilbao, SPAIN. Occupational Rhinoconjunctivitis Due to Hops Exposure in a Brewery Worker A. Garcia; Allergology, Ramon Y Cajal Hospital, Madrid, SPAIN. Occupational Pollinosis Induced by Radish and Chinese Cabbage Pollen N. Kwon, J. Park, J. Lee, S. Choi, C. Hong; Department of Internal Medicine, Division of Allergy and Immunology, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA.

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Poster Session 2408 Saturday, March 20 11:00 AM to 12:00 PM Clinical Significance of Pollen and Spore Counts 148 The Relationship Between Airborne Ascospores, Cladosporium and Rainfall Events T. J. Van Osdol, F. Hu, C. S. Barnes, J. Portnoy; Children’s Mercy Hospital, Kansas City, MO. 149 Predicting Onset and Severity of Pollen Seasons in a Semi-Arid Climate M. J. Schumacher1, M. Hjelmroos-Koski2, M. K. O’Rourke3; 1University Arizona Health Sciences Center, Tucson, AZ, 2University of California at Berkeley, Berkeley, CA, 3University Arizona, Tucson, AZ. 150 Interpretation of Pollen Exposure Data T. J. O’Meara1, B. J. Green2, J. K. Sercombe1, E. R. Tovey1; 1Woolcock Institute of Medical Research, Sydney, AUSTRALIA, 2University of Sydney, Sydney, AUSTRALIA.

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Climatic Variables Affecting Mold Spore Counts (MSC) in Newark, NJ 1987-2002 J. B. Hein, A. Port, L. Bielory; Allergy/Immunology, UMDNJ, Newark, NJ. Ragweed Pollen Forecasting E. Levetin; Biological Science, University of Tulsa, Tulsa, OK. Study of Moulds Sensitization Prevalence in Patients With Allergic Rhinitis and/or Asthma in Catalonia (Spain) J. Bartra1, W. Societat Catalana Allergia e Immunologia Clinica2; 1Hospital Universitari de Girona Dr. Josep Trueta, Girona (Spain), SPAIN, 2S.C.A.I.C, Catalunya, SPAIN. Pollen Count Variability M. S. Larsen-Purvis, K. Joshi, E. Levetin; Department of Biological Sciences, University of Tulsa, Tulsa, OK. The Effects of Light and Weather on Ragweed Season B. D. Lewis, C. S. Barnes, F. Hu, J. Shireman, J. M. Portnoy; Allergy/Immunology, UMKC - Children’s Mercy Hospital, Kansas City, MO. Cutaneous Sensitization to Common Aeroallergens in Patients Under 14 Years Old, in the Southwest of Madrid Region (Spain) A. Rosado, M. A. Tejedor, C. Vila, M. D. Alonso, M. FernándezRivas, E. González-Mancebo; Allergy Unit, Fundación Hospital Alcorcón, Alcorcón (Madrid), SPAIN. A Preliminary Investigation on the Atmospheric Mycoflora of Austin, TX, USA N. Udaya Prakash; Aerobiology Laboratory, Omni Environmental Inc, Austin, TX. Sensitization to Black Locust Pollen Among Patients With Pollinosis in Madrid E. Compés, S. Quirce, E. Hernández, J. Cuesta, M. de las Heras, J. Sastre; Allergy Department, Fundación Jimenez Díaz, Madrid, SPAIN. Rhinoconjunctivitis and Bronchial Asthma Due to Monosensitization to Quercus Pollen J. Bartra1, M. San Miguel-Moncin2, M. Lombardero3, R. Alonso4, B. Fernández Parra4, R. Tella4, A. Cistero-Bahima4; 1Hospital Universitari de Girona Dr. Josep Trueta, Girona (Spain), SPAIN, 2Institut Universitari Dexeus, Barcelona, Barcelona, SPAIN, 3Departamento I+D; ALK-Abello, Madrid, SPAIN, 4Institut Universitari Dexeus, Barcelona, SPAIN. Air Pollution and Pulmonary Function E. Thaller, L. Hollaway, V. Mai, D. Hochman, B. Bharti, E. Brooks, S. Petronella; UTMB, Galveston, TX. Prenatal Exposure to Organochlorine Compounds and Allergic Eczema in One Year Old Children P. Ciznar1,1, E. Reichrtova2, L. Palkovicova2, K. Rausova2, M. Veningerova2, A. Adamcakova-Dodd2, S. J. N. McNabb3; 1First Pediatric Clinic, Comenius University, Bratislava, SLOVAKIA, 2Environmental Health, Institute of Preventive and Clinical Medicine, Bratislava, SLOVAKIA, 3National Centers fo HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA. Effects of Air Pollutants on Basophil Degranulation C. R. Collaco, D. J. Hochman, M. Yngve, E. G. Brooks; Pediatrics, University of Texas Medical Branch, Galveston, TX. Personal Exposure to Nitrogen Dioxide and Changes of Lung Function in Asthmatics H. Kwon1, Y. Jee2, S. Lee1, S. Hwang1; 1Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, REPUBLIC OF KOREA, 2Department of Internal Medicine, Dankook University College of Medicine, Cheonan, REPUBLIC OF KOREA. The Combinatorial Effect of Both the Industrial and Coastal Environment on the Manifestation of Allergic Symptoms R. A. Rao, P. S. Kumar; Biochemistry, Andhra University, Visakhapatnam, INDIA.

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Effects of Fluoride and Mercury on Human Cytokine Response In Vitro G. de Vos1, E. Jerschow2, Z. Liao2, D. Rosenstreich2; 1Department of Allergy and Immunology, Albert Einstein College of Medicine, Bronx, NY, 2Allergy and Immunology, Albert Einstein College of Medicine, Bronx, NY. Comparison of Chemosensory Function and Psychological Profile in Patients With Idiopathic Environmental Intolerances (IEI)/Multiple Chemical Sensitivity (MCS), Odorant Sensitive and Insensitive Controls D. Papo1, B. Eberlein-Koenig2, H. Berresheim3, J. Huss-Marp1, V. Grimm1, J. Walkowiak3, U. Kraemer3, J. Ring2, G. Winneke3, H. Behrendt1; 1Division of Environmental Dermatology and Allergology, GSF/TUM, Neuherberg-Munich, Munich, GERMANY, 2Department of Dermatology and Allergy Biederstein, Technical University, Munich, GERMANY, 3Medical Institute of Environmental Hygiene, Heinrich-Heine University, Düsseldorf, GERMANY.

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Poster Session 2409 Saturday, March 20 11:00 AM to 12:00 PM Adverse Reactions to Drugs and Biologicals I 167 Desensitization to Methotrexate in Acute Lymphocytic Leukemia A. Des Roches1, L. Paradis1, A. Moghrabi2, S. Singer1; 1Department of Allergy, Hopital Sainte-Justine, Montreal, PQ, CANADA, 2Department of Haematology, Hopital Sainte-Justine, Montreal, PQ, CANADA. 168 Re-prescription of Penicillin in Patients Who Have Had Allergic-like Reactions: Investigation Using a Large Electronic Medical Record A. J. Apter1, J. L. Kinman2, W. B. Bilker2, M. Herlim2, D. J. Margolis3, E. Lautenbach1, S. Hennessy2, B. L. Strom2; 1Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, 2Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, 3Center for Clinical Epidemiology and Biostatistics, Dermatology, University of Pennsylvania, Philadelphia, PA. 169 Delayed Reaction Due to Trimebutine C. Martin Garcia, N. Martinez Borque, D. Martinez Bohigas, M. Torrecillas Toro, M. Palomeque Rodriguez; Allergy, Hospital Ntra. Sra. Perpetuo Socorro, Albacete, SPAIN. 170 Desensitization Reaction of Patients With Antituberculosis Drug Adverse Reactions B. S. Vicente; Department of Internal Medicine, Angeles University Foundation Medical Center, Angeles City, PHILIPPINES. 171 Detection of Specific IgE to Quinolones P. Campi1, M. Manfredi2, M. Severino1, S. Testi1, D. Macchia1, G. Ermini1, W. Pichler3; 1Allergy Clinic, Ospedale San Giovanni di Dio, Firenze, ITALY, 2Immunology and Allergy Laboratory, Ospedale San Giovanni di Dio, Firenze, ITALY, 3Clinic for Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern, SWITZERLAND. 172 Management of Hypersensitivity Reactions Caused by Oxaliplatin S. Infante1, P. Tornero1, M. Díaz-Jara1, M. N. Sánchez2, M. De Barrio1, M. Calvo1, T. Herrero1; 1Allergy Department, Hospital General Universitario Gregorio Marañón, Madrid, SPAIN, 2Pharmacology Department, Hospital General Universitario Gregorio Marañón, Madrid, SPAIN. 173 Management of Glatiramer Reactions: Experience With Desensitization S. R. Inamdar1, M. Rensel2, F. Hsieh3, T. Rambasek3, C. Radoji-

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cic3, H. Katz3, D. Lang3; 1Allergy and Immunology, University of Mississippi Medical Center, Madison, MS, 2Neurology, Cleveland Clinic Foundation, Cleveland, OH, 3Allergy and Immunology, Cleveland Clinic Foundation, Cleveland, OH. Allergy to Systemically Administered Corticoids A. Padial1, S. Posadas1, J. Alvarez1, M. J. Torres2, J. A. Alvarez3, C. Mayorga2, M. Blanca2; 1Allergy Service, La Paz Hospital, Madrid, SPAIN, 2Allergy Service, Carlos Haya Hospital, Malaga, SPAIN, 3Pathology Service, La Paz Hospital, Madrid, SPAIN. Role of the Basophil Activation Test (BASOTEST) in the Diagnosis of Immediate Allergic Reactions to Betalactams M. J. Torres1, C. Mayorga2, A. Padial3, C. Antunez2, J. A. Cornejo-Garcia2, J. L. Rodriguez-Bada2, M. Blanca1; 1Allergy Service, Carlos Haya Hospital, Málaga, SPAIN, 2Research Laboratory, Carlos Haya Hospital, Málaga, SPAIN, 3Allergy Service, La Paz Hospital, Madrid, SPAIN. Differential Expression Pattern and Functioning of CD80 and CD86 in Th1 and Th2 Immune Responses Induced by Immunogenic Drugs S. Nierkens1, M. Aalbers1, M. Oosterwegel2, P. van Kooten3, L. Boon4, R. Pieters1; 1Immunotoxicology, IRAS, Utrecht University, Utrecht, NETHERLANDS, 2Department of Immunology, University Medical Center, Utrecht, NETHERLANDS, 3Immunology Division, Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, NETHERLANDS, 4Bioceros B.V., Amsterdam, NETHERLANDS. Topical Tacrolimus Alcohol Induced Flush Presenting as Food Allergy A. K. Knight, M. J. Chandler; Mount Sinai Medical Center, New York, NY. Skin Testing Recommendations for Available Heterologous Immunoglobulin Products in the US H. S. Ko1, K. W. Chan2; 1Cber/OBRR/DH, Food and Drug Administration, Rockville, MD, 2M. D. Anderson Cancer Center, Houston, TX. Quality of Life in Patients With Adverse Reactions to Drugs: Preliminary Results From a New Questionnaire I. Baiardini, Jr.1, L. Guerra, Jr.1, M. Pasquali1, P. Bonadonna2, G. Passalaqua1, G. W. Canonica1; 1DiMI University of Genoa, Allergy and Respiratory Diseases, Genoa, ITALY, 2University of Verona, Allergy and Respiratory Diseases, Verona, ITALY. Desensitization to Allopurinol A. Spínola Santos1, M. Branco Ferreira1, A. Lopes Pregal1, S. Lopes Silva1, A. C. Costa1, A. Mendes1, E. Pedro1, M. Pereira Barbosa1, A. G. Palma-Carlos2; 1Immunoallergology Unit, Santa Maria Hospital, Lisbon, PORTUGAL, 2Immunoallergology Unit, Allergy and Clinical Immunology Center, Lisbon, PORTUGAL. Allergic Reactions to β-Lactams – In Vitro and In Vivo Diagnosis A. Lopes Pregal1, M. C. Santos2, A. Spínola Santos1, S. Lopes Silva1, M. Branco Ferreira1, E. Pedro1, G. Palma-Carlos1, M. L. Palma-Carlos2, A. G. Palma-Carlos2, M. Pereira Barbosa1; 1Immunoallergology Unit, Santa Maria Hospital, Lisbon, PORTUGAL, 2Hematology and Immunology Center, Lisbon Faculty of Medicine, Lisbon, PORTUGAL. A 10-Year Experience With Steven Johnson Syndrome and Toxic Epidermal Necrolysis at a Tertiary Burn Center A. Majmundar, R. Gruchalla, H. Earl; Allergy Immunology, University of Texas Southwestern, Dallas, TX. Lack of Risk of Sensitization Due to the Diagnostic Procedures (Skin Test and Challenge) in Patients With History of Recent Allergic Reaction to Amoxicillin P. Bonadonna, M. Schiappoli, A. Dama, M. A. Crivellaro, G. Senna; Allergy Unit, Verona General Hospital, Verona, ITALY. Low Risk of Cross-Reactivity to Cephalosporins Among Patients Allergic to Penicillins

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M. B. Bilò1, P. Bonadonna2, M. Schiappoli2, A. Dama2, M. A. Crivellaro2, G. Senna2; 1Allergy Unit - Dpt. of Respiratory Diseases, University Hospital, Ancona, ITALY, 2Allergy Unit, Verona General Hospital, Verona, ITALY. β-Lactam Allergy in Clinical Practice, Relevance of Clinical History and/or Laboratory Test B. Arnoux1, V. Kvedariene2, M. Rongier1, J. Bousquet1, P. Demoly3; 1U454, INSERM, Montpellier Cedex 05, FRANCE, 2U454, CHU Montpellier, Montpellier Cedex 05, FRANCE, 3Education Natoinale, Montpellier Cedex 05, FRANCE. Outpatient Penicillin Use After Negative Skin Testing and Penicillin Challenge in a Pediatric Population M. Nguyen, A. Des Roches, L. Paradis, M. Primeau, J. Paradis; Allergy Department, Hôpital Sainte-Justine, Montreal, PQ, CANADA. Carboplatin and Cisplatin Hypersensitivity - Pattern, Potential Mechanism, and Desensitization M. Fukui1, R. T. Penson2, V. Krishna1, M. V. Seiden2, C. N. Krasner2, J. T. Wong1; 1Clinical Allergy and Immunology, Massachusetts General Hospital, Boston, MA, 2Medical Gynecologic Oncology, Massachusetts General Hospital, Boston, MA. Differences in Antioxidant Enzyme Activity in Adverse Drug Reactions J. A. Cornejo-Garcia1, M. J. Torres2, C. Mayorga1, C. Antunez1, M. Blanca2, J. M. Matés3, C. Juarez1; 1Research Laboratory, Carlos Haya Hospital, Málaga, SPAIN, 2Allergy Service, Carlos Haya Hospital, Málaga, SPAIN, 3Biochemistry and Molecular Biology Department, Málaga University, Málaga, SPAIN. Near-Fatal Anaphylaxis to Patent Blue V S. Wohrl1, M. Focke2, G. Hinterhuber3, G. Stingl1, M. Binder3; 1Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, University of Vienna Medical School (AKH Wien), Vienna, AUSTRIA, 2Division of Immunopathology, Department of Pathophysiology, University of Vienna Medical School (AKH Wien), Vienna, AUSTRIA, 3Division of General Dermatology, Department of Dermatology, University of Vienna Medical School (AKH Wien), Vienna, AUSTRIA. T Cell-Mediated Immunity to Quinolones D. A. Schmid; Clinic for Rheumatology and Clinical Immunology/Allergology, Bern, SWITZERLAND. New Scheme of Oral Rapid Desensitization to TMP-SMX in HIV-Infected Patients. Efficacy and Safety P. Mantilla Guevara1, G. R. Hernandez Vivas1, V. A. Quintero Parada1, C. R. Pérez Pérez2, M. I. Rivera Suarez3; 1Immunology, Instituto de Oncología y Hematología, Caracas, VENEZUELA, 2Immunology, Hospital JM de los Ríos, Caracas, VENEZUELA, 3Immunology, Centro de Inmunología IVSS, Caracas, VENEZUELA. Recognition of Allergenic Determinants to Cefaclor in Patients With Cefaclor-Induced Anaphylaxis S. Kim1, J. Choi2, H. Park2; 1Internal Medicine, Nowon Eulji Hospital, Seoul, REPUBLIC OF KOREA, 2Department of AllergyRheumatology, Ajou University School of Medicine, Suwon, REPUBLIC OF KOREA.

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Poster Session 2410 Saturday, March 20 11:00 AM to 12:00 PM Insect and Latex Allergy 193 The Sequence of Sol i 1 the Cross-Reactive Allergen of Imported Fire Ant Venom M. Schmidt1, R. H. Sakell2, D. R. Hoffman2; 1Biology, East Carolina University, Greenville, NC, 2Pathology and Laboratory Medicine, Brody School of Medicine, Greenville, NC.

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Comparison of Venom Protease Allergens From Bees and Paper Wasps D. R. Hoffman1, C. D. Fitch1, M. Schmidt2; 1Pathology and Laboratory Medicine, Brody School of Medicine, Greenville, NC, 2Biology, East Carolina University, Greenville, NC. Role of Recombinant Mosquito Salivary Allergens in the Diagnosis of Individuals with Allergic Reactions to Mosquito Bites A. N. Beckett, W. Sun, F. E. R. Simons, Y. Ma, Z. Peng; Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, CANADA. Venom Immunotherapy (VIT) for Large Local Reactions (LLR) to Insect Stings: A Pilot Study D. B. K. Golden, R. G. Hamilton, D. Kelly, A. Kagey-Sobotka, P. S. Norman, L. M. Lichtenstein; Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD. A Case of Leukocytoclastic Vasculitis Following Insect Immunotherapy S. D. Betschel1, G. L. Sussman2; 1University Of Toronto, Toronto, ON, CANADA, 2Allergy and Clinical Immunology, University Of Toronto, Toronto, ON, CANADA. Prevalence of Allergic Sensitivity to Imported Fire Ants in Children From an Endemic Region E. L. Caplan, J. L. Ford, P. F. Young, D. R. Ownby; Allergy and Immunology, Medical College of Georgia, Augusta, GA. The Natural History of Cutaneous Reactions to Imported Fire Ant Stings in Children S. A. Nguyen, D. C. Napoli; Allergy/Immunology, Wilford Hall Medical Center, San Antonio, TX. Bronchial Reactivity in Hymenoptera Venom Allergic Patients R. Gawlik, Z. Brzoza, B. Rogala; Head and Clinic of Internal, Allergic Diseases and Clinical Immunology, Silesian University School of Medicine, Zabrze, POLAND. Anaphylaxis to Stinging Insect With Myocardial Infarction: A Case Report C. C. Randolph; Allergy, Yale/Waterbury Affiliate, Waterbury, CT. Fire Ant Sting Anaphylaxis in Australia G. O. Solley1, C. Vanderwoude2; 1Watkins Medical Centre, Brisbane, Queensland, AUSTRALIA, 2Fire Ant Control Centre, Brisbane, Queensland, AUSTRALIA. Case Report: Bullous Scarring Reactions After Imported Fire Ant (IFA) Envenomation D. D. Albright, L. L. Hagan; Department of Allergy and Immunology, Wilford Hall Medical Center, Lackland Air Force Base, TX. Unusual Neurological Reaction in a Patient Allergic to Wasp Venom W. Pfützner, A. Niedermeier, F. Rueff, B. Przybilla; Klinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, Munich, GERMANY. Specific IgE-Binding of rHev b 12 Is Restricted to Fruit-Allergic Patients H. P. Rihs1, F. Rueff2, M. Lundberg3, P. Rozynek1, J. Garcia-Selles4, D. Barber5, S. Scheurer6, R. Alonso7, A. Cistero-Bahima7, T. Bruning1, M. Raulf-Heimsoth1; 1BGFA, Bochum, GERMANY, 2LMU, Munich, GERMANY, 3MIAB, Uppsala, SWEDEN, 4Hopital Virgen de la Arrixaca, Murcia, SPAIN, 5ALK-Abello, Madrid, SPAIN, 6P.E.I, Langen, GERMANY, 7Institute Universitari Dexeus, Barcelona, SPAIN. A New Latex Allergen Classified Into the Plant Defense-Related Reductase Family T. Yagami1, Y. Haishima1, T. Tsuchiya1, A. Tomitaka-Yagami2, H. Kano2, K. Matsunaga2; 1Division of Medical Devices, National Institute of Health Sciences, Tokyo, JAPAN, 2Department of Dermatology, Fujita Health University School of Medicine, Toyoake, JAPAN. Profile of Sensitization to Individual Latex Allergens Among Health Care Workers Allergic to Natural Rubber Latex

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J. Sastre1, M. Raulf-Heimsoth2, M. Fernandez-Nieto1, D. Barber3, S. Martin4, S. Quirce1; 1Allergy, Fundacion Jimenez Diaz, Madrid, SPAIN, 2Allergy, BGFA, Bochum, GERMANY, 3ALK-Abello, Madrid, SPAIN, 4Medical Department, ALK-Abello, Madrid, SPAIN. Antigenic Latex Protein From Rubber Bands K. Yoon1, J. F. Halsey2, K. T. Kim1; 1Allergy, Asthma & Respiratory Care Medical Center, Long Beach, CA, 2IBT Reference Laboratory, Lenexa, KS. Prevalence of IgE Antibodies to Extensively Purified Hev b13 and Hev b2 in Natural Rubber Latex (NRL) Allergic Patients T. Palosuo1, M. Lehto2, A. Kotovuori3, N. Kalkkinen3, H. Alenius2, T. Reunala4, K. Turjanmaa4; 1Department of Health and Functional Ability, National Public Health Institute, Helsinki, FINLAND, 2Institute of Occupational Health, Helsinki, FINLAND, 3Institute of Biotechnology, University of Helsinki, Helsinki, FINLAND, 4Department of Dermatology, Tampere University Hospital, Tampere, FINLAND. Prevalence of Latex-Specific IgE Antibody Among the Children With/Without Allergic Disease in Japan K. Akashi1, M. Akashi1, M. Narita1, T. Suda1, I. Nomura1, Y. Ohya1, A. Akasawa2; 1Allergy and Immunology, National Center for Child Health and Development, Setagaya-ku, Tokyo, JAPAN, 2Interdisciplinary Medicine, National Center for Child Health and Development, Setagaya-ku, Tokyo, JAPAN. Performance of Methods for the Measurement of Natural Rubber Latex (NRL) Proteins, Antigens and Allergens V. J. Tomazic-Jezic1, D. H. Beezhold2, H. Hashim3, T. Palosuo4, M. Raulf-Heimsoth5, M. Swanson6, R. G. Hamilton7; 1FDA, Rockville, MD, 2NIOSH, Morgantown, WV, 3RRIM, Kuala Lumpur, MALAYSIA, 4NPHI, Tampere, FINLAND, 5BGFA, Bochum, GERMANY, 6Mayo Clinic, Rochester, MN, 7Johns Hopkins Univ., Baltimore, MD. Diagnosis of Natural Rubber Latex Allergy by the Basotest Method M. Hemery1, M. Rongier2, H. Dhivert-Donnadieu3, E. Barbotte4, R. Verdier4, P. Demoly5, B. Arnoux2; 1Service d’allergologie, CHU Montpellier, Montpellier Cedex 05, FRANCE, 2Inserm u454, INSERM, Montpellier Cedex 05, FRANCE, 3Allergologie, CHU Montpellier, Montpellier Cedex 05, FRANCE, 4Département d’Information Médicale, CHU Montpellier, Montpellier Cedex 05, FRANCE, 5Exploration des Allergies, CHU Montpellier, Montpellier Cedex 05, FRANCE. The Ficus-Fruit-Syndrome Is a Distinct Entity Not Related to Natural Rubber Latex Allergy W. Hemmer, M. Focke, M. Götz, R. Jarisch; Floridsdorf Allergy Center, Vienna, AUSTRIA.

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Poster Session 2411 Saturday, March 20 11:00 AM to 12:00 PM Burden of Allergic Disease 214 Quality of Patient Reported Outcome Data Captured Using Paper and Interactive Voice Response Diaries in an Allergic Rhinitis Study; Is Electronic Data Capture Really Better? K. Weiler1, A. Christ2, G. Woodworth3, R. Weiler2, J. M. Weiler1; 1CompleWare Corporation and Iowa Clinical Research Corporation, Iowa City, IA, 2CompleWare Corporation, Iowa City, IA, 3CompleWare Corporation and University of Iowa, Iowa City, IA. 215 Life Quality in Patients Presenting Allergic Rhinitis M. A. Calvo, Sr.; Pediatrics Institute, Austral University, Valdivia, CHILE. 216 Result of QOL Scores in Contrast With the Psychological Test Scales in Asthma Patients

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M. Haida, Y. Tsuchikawa; Department of Allergy and Respiratory Diseases, Hanzomon Hospital, Tokyo, JAPAN. A Pre-operative Allergy Clinic: The First Thousand Patients M. A. Park, P. Markus, A. Madaan, J. Li; Division of Allergic Disease, Mayo Clinic, Rochester, MN. Determination of the Accuracy of Antimicrobial Allergy History in the Medical Records of Hospitalized Patients C. B. Lauter1, R. A. McPhee2; 1Division of Allergy - Immunology, William Beaumont Hospital, Royal Oak, MI, 2Allergy, Henry Ford Hospital, Detroit, MI. Budget Model for Estimating Economic Impact of Fluticasone Propionate/Salmeterol via Diskus® in an Adult Asthma Population J. Mauskopf1, T. Shih2, R. D. Borker3, B. Tano4, R. Stanford3, P. Jhingran3; 1RTI Health Solutions, Research Triangle Park, NC, 2Global Health Outcomes, University of Texas MD Anderson Cancer Center, Houston, TX, 3Global Health Outcomes, GlaxoSmithKline, Research Triangle Park, NC, 4Global Health Outcomes, Ohio State University/GlaxoSmithKline, Research Triangle Park, NC. A Clinical Quality Assessment Comparing Actual Practice to Standard of Care in Patients With Anaphylaxis Y. J. Tsai1, M. Halasyamani1, E. Robinson1, M. McMorris2; 1St. Joseph Mercy Hospital, Ann Arbor, MI, 2University of Michigan Medical School, Ann Arbor, MI. Asthma in the Elderly: Results From TENOR R. G. Slavin1, T. Haselkorn2, H. Zayed3, K. Miller2, E. Warren2, B. Zheng2, S. Wenzel2; 1Internal Medicine, Division of Allergy, Saint Louis University Sch Med, St. Louis, MO, 2Genentech, South San Francisco, CA, 3Quintiles Late Phase, San Francisco, CA. Demographics and Long-Term Follow-Up in a Veteran Affairs Allergy/Immunology Clinic: A 10-Year Analysis S. Gupta, W. B. Klaustermeyer; V A Greater Los Angeles Med Ctr, Los Angeles, CA. Serum IgE and Lung Function in the TENOR Asthma Cohort L. C. Borish1, M. K. Miller2, B. Zheng2, C. M. Dolan2, Y. Deniz2; 1University of Virginia Health Systems, Charlottesville, VA, 2Genentech, South San Francisco, CA. Addressing the Burden of Asthma in San Francisco Through the San Francisco Asthma Task Force P. Strub1, B. Conner-Andersen2, R. Castro3, L. Kroon3, M. Alioto3, J. McKown4, M. Hoemke5, K. Cohn6, D. Rossi7, B. Saiki8, N. Warren9, & The San Francisco Asthma Task Force9, & District 10 Supervisor, Sophenia Maxwell10; 1Kaiser Permanente Medical Center, San Francisco, CA, 2Peninsula Allergy Associates, Burlingame, CA, 3University of California, San Francisco, CA, 4St. Luke’s Health Care Center, San Francisco, CA, 5San Francisco Unified School District (retired), San Francisco, CA, 6San Francisco Department of Public Health, San Francisco, CA, 7Wu Yee Children’s Services, San Francisco, CA, 8American Lung Association, San Francisco and San Mateo Counties, CA, 9San Francisco Asthma Task Force, San Francisco, CA, 10San Francisco, City and County Board of Supervisors, San Francisco, CA. Comparison of Quality of Life of Asthmatic Children: Pediatricians vs Pediatric Allergists E. Yousef, S. J. McGeady; Division of Allergy and Clinical Immunology, Thomas Jefferson University, Wilmington, DE. Co-morbidities in Adults With Asthma: Cross-sectional Analyses Using 2001 Behavioral Risk Factor Surveillance Survey (BRFSS) Data H. J. Zeitz1, M. N. Lutfiyya2, J. L. Kappleman3, J. E. McCullough4; 1Department of Medicine, Univ of IL College Medicine, Rockford, IL, 2Department of Family and Community Medicine, Univ of IL College Medicine, Rockford, IL, 3Univ of IL College Medicine, Rockford, IL, 4Chicago Department of Public Health, Chicago, IL. Reduced Emergency and Hospital Utilization Following Home Assessment and Case Management

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E. M. Jones, C. S. Barnes, F. Pacheco, F. Hu, J. M. Portnoy; Allergy/Asthma/Immunology, Children’s Mercy Hospital, Kansas City, MO. The Financial Impact of an Acute Asthma Emergency Department Visit on Low-Income Families in Los Angeles S. A. McGhee1, C. Sherbourne2, M. Lara2; 1Department of Pediatrics, Mattel Children’s Hospital at UCLA, Los Angeles, CA, 2UCLA/RAND Program on Latino Children with Asthma, RAND Corporation, Los Angeles, CA.

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Poster Session 2412 Saturday, March 20 11:00 AM to 12:00 PM Mast Cells/Basophils/IgE 229 Evidence That Thrombopoietin (TPO) Is Capable of Supporting Human Mast Cells A. S. Kirshenbaum, D. D. Metcalfe; Niaid/lad, National Institutes of Health, Bethesda, MD. 230 Prevalence of Increased Serum Total IgE and Specific Aeroallergen Sensitivity in 5-8 Year Old Alaska Native Children G. J. Redding1, R. J. Singleton2, T. C. Lewis3, P. Martinez4, J. DeMain2, B. Morray5, H. Peters2, L. Bulkow2, C. Jones2, D. Stamey5, J. C. Butler2; 1Pediatrics, University of Washington School of Medicine, Seattle, WA, 2Centers for Disease Control, Anchorage, AK, 3University of Michigan School of Medicine, Ann Arbor, MI, 4Yukon Kuskokwin Delta Regional Hospital, Bethel, AK, 5University of Washington School of Medicine, Seattle, WA. 231 Chemokine Gene Expression in CD133 Cord Blood Derived Human Mast Cells and Modulation by Cyclosporin A and Dexamethasone M. Holm1,2, H. K. Nielsen1, H. B. Andersen1, P. O. Schiotz1, S. Junker2; 1Pediatric Department, Aarhus University Hospital, Aarhus, DENMARK, 2Institute of Human Genetics, Aarhus University, Aarhus, DENMARK. 232 Cutaneous Anaphylaxis in Mice to Der p 2 Independent of IgE and IgG1 F. A. Redegeld, M. Kool, B. Blokhuis, A. Kraneveld, F. Nijkamp; Utrecht University, Utrecht Institute for Pharmaceutical Sciences, Utrecht, NETHERLANDS. 233 Lysophosphatidic Acid Induces Human Mast Cell Activation in an IL-4-Dependent Manner D. A. Lin, S. Bagga, J. A. Boyce; Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA. 234 Cultured Human Mast Cells Express a Novel Gs-Coupled Purinergic Receptor A. G. Mery1, E. A. Beller1, J. A. Boyce2; 1Rheumatology,Immunology, Allergy, Brigham and Women’s, Boston, MA, 2Harvard Medical School, Boston, MA. 235 A Randomized Double-Blind, Placebo-Controlled Study to Assess the Effects of Omalizumab (Humanized Monoclonal Anti-IgE Antibody) on the Early- and Late-Phase Skin Reactions and Cellular Infiltrate After Multiple Intradermal Allergen Challenges Y. Ong1, A. Menzies-Gow1, J. Matthews2, A. B. Kay1; 1Allergy and Clinical Immunology, Imperial College, NHLI Division, London, UNITED KINGDOM, 2Novartis Horsham Research Centre, West Sussex, UNITED KINGDOM. 236 Expression of CD33-Related Siglecs on Human Eosinophils, Basophils and Mast Cells E. Nutku1, H. Aizawa1, L. H. K. Lim1, H. Tashimoto1, S. Hudson1, P. Crocker2, B. Bochner1; 1Clinical Immunology, Johns Hopkins University, Baltimore, MD, 2University of Dundee, Dundee, UNITED KINGDOM. 237 Canine Mastocytoma CM-MC Cells Express Two Variants of High-Affinity Receptors for IgG

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R. Nakamura1, Y. Sato2, K. Takagi1, N. Sasaki2, J. Sawada1, S. Kitani3, R. Teshima1; 1Div Biochem Immunochem, Natl Inst Health Sci, Tokyo, JAPAN, 2Univ Tokyo, Tokyo, JAPAN, 3Tokyo Univ Fisheries, Tokyo, JAPAN. Transfection of a Rat Cell Line With the Genes of the Human High Affinity IgE Receptor Yields a Model Mast Cell That Reacts With Human IgE L. Vogel, D. Lüttkopf, L. Hatahet, S. Vieths, D. Haustein; Dept. of Allergology, Paul-Ehrlich-Institut, Langen, GERMANY. Interleukin-3 and Interleukin-18 Induce Leukotriene Synthesis in KU812 Cells M. Zaitsu1,2, T. Midoro-Horiuti1, R. M. Goldblum1, Y. Hamasaki2; 1Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, 2Department of Pediatrics, Saga Medical School, Saga, JAPAN. Successful Treatment of Systemic Mastocytosis With High Dose Interferon Alfa: Long-Term Follow-Up of a Case J. H. Butterfield1, G. F. Kozuh2; 1Mayo Clinic & Foundation, Rochester, MN, 2Oncology Joint Practice, Wheaton, IL. Studies on the Regulation of IgE Expression by the use of “Knock In” Mice G. Achatz1, A. Karnowsky2, M. C. Lamers2, G. Achatz-Straussberger1; 1Institute for Genetics, Salzburg, AUSTRIA, 2MPI for Immunobiology, Freiburg, GERMANY. Autoimmune Chronic Urticaria Is Caused by IgG3 and IgG1 Autoantibodies to the α Subunit of the IgE Receptor S. Soundararajan, K. Joseph, A. P. Kaplan; Medine/Pulmonary, Medical University of South Carolina, Charleston, SC. Cross-reactivity of Shrimp, Abalone and Derp1 B. Sun1,2, A. Wu3, N. Zhong2; 1Dept of Medicine, The University of Hong Kong, Hong Kong, CHINA, 2Guangzhou Institute of Respiratory Disease, Guangzhou, CHINA, 3The University of Hong Kong, Hong Kong, CHINA. α4β7 Integrin Is Required for the Inflammatory Recruitment of Mast Cell Progenitors to the Lung J. P. Abonia, M. F. Gurish, D. S. Friend, K. F. Austen, J. A. Boyce; Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA. Intestinal IgE Secretion in Food Allergy: Potential Role for CD23 Isoforms on Intestinal Epithelial Cells C. Berin1, P. Beuria2, A. Nowak-Wegrzyn1, K. Sperber2; 1Pediatrics, Mount Sinai School of Medicine, New York, NY, 2Clinical Immunology, Mount Sinai School of Medicine, New York, NY. Human Mast Cells Express Inducible PGE Synthase and Generate PGE2 in Response to TLR2-Dependent Activation C. Feng, E. A. M. Beller, J. A. Boyce; Rheumatology, Immunology and Allergy, Brigham & Women’s Hospital, Boston, MA. Transcription Factors of Mast Cells in Comparison With Monocytes and Granulocytes: Characterization of the Mature Human Mast Cell as C/EBPαlow, C/EBPε-, PU.1low, GATA-1low, GATA-2+, Elf-1+, SCL+, MITFhigh M. Babina1, S. Guhl1, Y. Schulke1, L. Kirchhof1, B. M. Henz1, A. F. Gombart2; 1Dept. Dermatol., Charite Clinic Berlin, Berlin, GERMANY, 2Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, CA. Expression of SNARE Proteins as Potential Regulators of Exocytosis in the Basophil-like Cell Line KU-812 R. Dyatlova, A. D. Befus, R. Moqbel; Department of Medicine, University of Alberta, Edmonton, AB, CANADA. In Vivo Association of Cytokine Production and IgE Levels in Infants and Adults E. Crestani1,2, S. Guerra1, I. C. Lohman1, G. L. Tebow1, F. D. Martinez1, A. L. Wright1, M. Halonen1; 1Arizona Respiratory Center, University of Arizona, Tucson, AZ, 2Department of Pediatrics, University of Verona, Verona, ITALY. CpG-Oligonucleotides Induce the Production of Th1 Type

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Cytokines From Mouse Bone Marrow Derived Mast Cells S. Lehtimäki, A. Lauerma, H. Wolff, H. Alenius; The Finnish Institute of Occupational Health, Helsinki, FINLAND. Modulation of the IgE Response by Blocking Membrane IgE D. Infuehr, G. Achatz; Institute for Genetics, Salzburg, AUSTRIA. Relationship Between the Sensitization to Outdoor Aeroallergen and the Month of Birth Y. M. Park, H. Choi, Y. Ahn, K. Son; Pediatrics, Eulji University School of Medicine, Seoul, REPUBLIC OF KOREA. IRp60 Is Expressed and Functional on Human Cord Blood Derived Mast Cells I. Bachelet1, A. Munitz1, A. Nagler2, G. J. Gleich3, L. Moretta4,5, A. Moretta4, F. Levi-Schaffer1; 1Department of Pharmacology, The Hebrew University, School of Pharmacy, Jerusalem, ISRAEL, 2Department of Haematology, The Chaim Sheba Center, TelHashomer, ISRAEL, 3Department of Dermatology and Medicine, University of Utah, Salt Lake City, UT, 4Dipartimento di Medicina Spermintale, Universita’ degli Studi di Genova, Genova, ITALY, 5Istituto Giannina Gaslini, Genova, ITALY. Is the Autologous Serum Skin Test Useful Only in Chronic Urticaria? A Study in Respiratory Patients A. Mari; Allergy Unit, National Health Service, Latina, ITALY. Mast Cell-Derived Plasminogen Activator Inhibitor-1 in the Airways of a Murine Asthma Model and Its Regulation by Cysteinyl Leukotrienes S. H. Cho1, J. A. Boyce2, E. A. Mellor2, J. M. Park1, C. K. Oh1; 1Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, 2Internal Medicine, Brigham and Women’s Hospital, Boston, MA. Modulation of Signaling Proteins in Cultured Mast Cells From Chronic Idiopathic Urticaria Patients B. M. Vonakis1, K. H. Nocka2, S. Rao2, S. Gibbons, Jr.1, K. Vasagar1, S. S. Saini1; 1Medicine, Johns Hopkins University, Baltimore, MD, 2Target Discovery and Bioinformatics, UCB-Pharma, Cambridge, MA. Relationship Between Syk Protein and Degranulation in Basophils From Chronic Urticaria Donors S. S. Saini, S. Gibbons, Jr., K. Vasagar, B. M. Vonakis; JHAAC, Baltimore, MD. Identification of Granulocyte Subtype-Selective Receptors and Ion Channels by High-Density Oligonucleotide Probe Array X. Yang1, T. Nakajima2, M. Iikura3, Y. Okayama4, K. Matsumoto2, C. Uchiyama5, T. Shirakawa6, K. Hirai3, H. Saito4,7, C. N. Adra1,8; 1Medicine, BIDMC, Harvard Medical School, Boston, MA, 2National Research Institute for Child Health & Development, Tokyo, JAPAN, 3Department of Bioregulatory Function, University of Tokyo, Tokyo, JAPAN, 4Laboratory for Allergy Transcriptome, RIKEN Research Center for Allergy & Immunology, Yokohama, JAPAN, 5University of Tokyo, Tokyo, JAPAN, 6Department of Health Promotion and Human Behavior, Kyoto University, Kyoto, JAPAN, 7Department of Allergy and Immunology, National Research Institute for Child Health & Development, Tokyo, JAPAN, 8The Children’s Hospital, Boston, MA. Mast Cell-Fibroblast Interactions: Role of Monomeric IgE in MMP-9 Upregulation H. Vliagoftis, M. Abel; Department of Medicine, University of Alberta, Edmonton, AB, CANADA. Selective Cyclooxygenase-2-Inhibitors Can Modulate IgEMediated Histamine Release In Vitro A. Babakhin1, L. M. DuBuske2; 1Institute of Immunology, National Research Center, Moscow, RUSSIAN FEDERATION, 2Immunology Research Institute of New England, Fitchburg, MA. Antibody Response to Natural Rubber Latex Following Mucosal Exposure S. J. McGeady; Thomas Jefferson University, Philadelphia, PA. Cultured Mast Cells (MC) From Histamine Releasing Factor-

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Poster Session 2413 Saturday, March 20 11:00 AM to 12:00 PM Allied Health Poster Sessions 264 How Effort Independent Measures of Respiratory Resistance Compare to the Gold Standard (FEV1) E. O. Corazalla1, M. N. Blumenthal1, A. T. Johnson2; 1University of Minnesota, Minneapolis, MN, 2University of Maryland, College Park, MD. 265 Perception of Risk of Death From Asthma in Adolescents E. Horowitz1, D. Joyner1, F. Malveaux2, A. Togias1; 1Johns Hopkins University, Baltimore, MD, 2Howard University, Washington, DC. 266 Study on the Fungal Aeroallergen Concentration in the Texas Panhandle Using a Burkard Volumetric Spore Trap N. Ghosh1, R. Camacho1, C. Saadeh2, M. Gaylor2, D. W. Smith3; 1Life Sciences, West Texas A & M University, Canyon, TX, 2Allergy Clinic, AARTS Allergy Clinic, Amarillo, TX, 3Biology, University of North Texas, Denton, TX. 267 The Relationship Between the Number of Patients With Cedar Fever and the Dosage of Medication During Cedar Pollination Season in Fukuoka City, Japan R. Kishikawa1, E. Kotoh1, T. Shimoda, Sr.1, S. Shoji, Sr.1, S. Nishima, Sr.2; 1Allergology, The Minami Fukuka Hospital Clinical Research Center, Fukuoka, JAPAN, 2Pediatrics, The Minami Fukuka Hospital Clinical Research Center, Fukuoka, JAPAN. 268 The Study of Nebulizer (Accessory Instrument) Using Problems in Asthma Children H. Yoon1, W. Kim2; 1Pediatrics, Kangnam Sacred Heart Hospital, Hallym University, Seoul, REPUBLIC OF KOREA, 2Pediatrics, Seoul Paik Hospital, Inje University, Seoul, REPUBLIC OF KOREA.

Oral Abstract Session 2601 Saturday, March 20 1:30 PM to 2:45 PM Molecular and Cellular Mechanisms in Allergy 1:30 269 Sex-Specific Protective Effects of Interleukin-9 Receptor Gene Haplotypes on Childhood Wheezing E. Melén1,2, H. Gullstén3, M. Zucchelli4, A. Lindstedt3, F. Nyberg1, G. Pershagen1, M. Wickman5, J. Kere4; 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SWEDEN, 2Centre for Allergy Research, Karolinska Institutet, Stockholm, SWEDEN, 3Clinical Research Centre, Huddinge University Hospital, Stockholm, SWEDEN, 4Centre for Biotechnology at Novum, Karolinska Institutet, Stockholm, SWEDEN, 5Department of Occupational and Environmental Health, Karolinska Hospital, Stockholm, SWEDEN. 1:45 270 ISS Inhibits Expression of MMP-9 and MMP-2 in a Mouse Model of Airway Remodeling

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J. Cho; Medicine, University of California San Diego, La Jolla, CA. 2:00 271 Anti-IL-5 Treatment (Mepolizumab) Reduces EosinophilAssociated TGF-β Relationship to Deposition of Extracellular Matrix Proteins in the Bronchial Subepithelial Basement Membrane of Mild Atopic Asthmatics P. Flood-Page1, A. N. Menzies-Gow1, S. Phipps1, S. Ying2, A. Wangoo1, M. S. Ludwig3, N. C. Barnes4, D. S. Robinson1, A. B. Kay1; 1Allergy and Clinical Immunology, Imperial College, NHLI Division, London, UNITED KINGDOM, 2Asthma, Allergy and Lung Biology, Guy’s Hospital, London, UNITED KINGDOM, 3Meakins Christie Laboratories, McGill University Hospital, Montreal, PQ, CANADA, 4Respiratory Medicine, Barts and the Royal London Hospitals Trust, London, UNITED KINGDOM. 2:15 272 Racial Differences in T Lymphocyte Response to Glucocorticoids J. D. Spahn1, R. A. Covar1, M. J. Federico2, E. E. Brown1, D. Y. M. Leung1; 1Pediatrics, National Jewish Medical and Research Center, Denver, CO, 2Pediatric Pulmonary, The Children’s Hospital, Denver, CO. 2:30 273 Analysis of Th2-Specific Chemokines in Exhaled Breath Condensate From Asthmatic Children T. F. Leung1, G. W. K. Wong1, F. W. S. Ko2, C. Y. Li1, C. K. Wong3, E. Yung1, C. W. K. Lam3, T. F. Fok1; 1Department of Pediatrics, The Chinese University of Hong Kong, Hong Kong SAR, HONG KONG SPECIAL ADMINISTRATIVE REGION OF CHINA, 2Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, HONG KONG SPECIAL ADMINISTRATIVE REGION OF CHINA, 3Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, HONG KONG SPECIAL ADMINISTRATIVE REGION OF CHINA.

Oral Abstract Session 2602 Saturday, March 20 1:30 PM to 2:45 PM Anti-Inflammatory Treatment of Asthma 1:30 274 Identifying Corticosteroid Dose Regimens That Do Not Inhibit Growth P. T. Daley-Yates, D. H. Richards; GlaxoSmithKline R&D, Greenford, UNITED KINGDOM. 1:45 275 Combination of IL-2 and IL-4 Inhibits Glucocorticoid Receptor Alpha (GCR-alpha) Nuclear Translocation in Peripheral Blood Mononuclear Cells (PBMC) and This Effect Is Reversed by Gamma Interferon E. Goleva1, R. J. Martin2, D. Y. M. Leung1; 1Department of Pediatrics, National Jewish Medical & Research Center, Denver, CO, 2Department of Medicine, National Jewish Medical & Research Center, Denver, CO. 2:00 276 Evaluation of Inhaled Corticosteroid (ICS) Use Before Exacerbations in Pediatric Patients With Asthma P. Patel1, M. Johnsrud2, L. McDermott1, B. Parasuraman1; 1AstraZeneca, Wilmington, DE, 2The University of Texas at Austin, Austin, TX. 2:15 277 Loss of Asthma Control When Patients Receiving Fluticasone Propionate/Salmeterol 100/50µg Diskus® Are “SteppedDown” to Fluticasone Propionate, Salmeterol or Montelukast Alone

S. Keonig1, K. Waitkus-Edwards2, S. Yancey2, B. Prillaman2, P. Dorinsky2; 1University of Virginia, Charlottesville, VA, 2GlaxoSmithKline, Research Triangle Park, NC. 2:30 278 Protective Effect of Montelukast on Both Lower and Upper Respiratory Responses to Acute Cat Allergen Exposure R. A. Wood1, T. Perry1, G. Philip2, J. Corren3, M. Malice2, R. Massaad2, T. F. Reiss2; 1Johns Hopkins Asthma and Allergy Center (Johns Hopkins University School of Medicine), Baltimore, MD, 2Merck & Co., Inc., Rahway, NJ, 3Allergy Research Foundation, Inc., Los Angeles, CA.

Oral Abstract Session 2603 Saturday, March 20 1:30 PM to 2:45 PM Immunomodulation 1:30 279 Cat Allergen Sensitivity in HLA DR1-Transgenic Mice: A Model to Investigate Mechanisms of Prophylactic Allergen Tolerance D. Campbell1, S. McMillan1, H. Gronlund2, M. van Hage-Hamsten2, D. Altmann3, M. Larché4, C. Lloyd1; 1Leukocyte Biology Section, Biomedical Sciences Division, Imperial College London, London, UNITED KINGDOM, 2Karolinska Institutet, Stockholm, SWEDEN, 3Department of Infectious Diseases, Imperial College London, London, UNITED KINGDOM, 4National Heart & Lung Institute, Imperial College London, London, UNITED KINGDOM. 1:45 280 Effect of Maternal Allergy on Effector Responses in the Neonates H. Uthoff1, A. Spenner1, W. Reckelkamp1, R. Hackler2, F. Hardung3, A. Scheffold3, H. Renz1, U. Herz1; 1Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps-University, Marburg, GERMANY, 2Internal Medicine - Cardiology, Hospital of the Philipps-University, Marburg, GERMANY, 3Deutsches Rheumaforschungszentrum, Berlin, GERMANY. 2:00 281 Circulating ICAM-1, VCAM-1, E-selectin, P-selectin and TNFαRII in Patients With Coronary Artery Disease A. Masood, A. Masood; Immunology, Tehran university, Tehran, IRAN (ISLAMIC REPUBLIC OF). 2:15 282 Mast Cells Generate Intracellular Reactive Oxygen Species That Are Involved in Ag Mediated Degranulation. Evidence for the Lack of Involvement of Endogenous Nitric Oxide E. J. Swindle1,2; 1Lad, niaid, NIH, Bethesda, MD, 2Pharmacology, The University of Liverpool, Liverpool, UNITED KINGDOM. 2:30 283 The Effect of TGF-β1 on Adhesion Molecule and Chemokine Receptor Expression on Naive T-Cells S. Maggadottir1, B. Gunnlaugsdottir2, B. R. Ludviksson1; 1Department of Immunology, Landspitali - University Hospital, Reykjavík, ICELAND, 2Center for Rheumatology Research, Landspitali - University Hospital, Reykjavík, ICELAND.

Oral Abstract Session 2604 Saturday, March 20 1:30 PM to 2:45 PM Mechanisms of Skin Inflammation in Atopic Dermatitis 1:30 284 T Regulatory Cells in Atopic Dermatitis (AD) and Subversion of Their Activity by Superantigens

L. S. Ou, E. Goleva, D. Y. M. Leung; Department of Pediatrics, National Jewish Medical & Research Center, Denver, CO. 1:45 285 Elevated Levels of IL-10 in Intrinsic (IAD) and Extrinsic Atopic Dermatitis (EAD) Is Associated With Deficiency in AntiMicrobial Peptide (AMP) Production D. Y. M. Leung1, N. Novak2, M. Boguniewicz1, T. Bieber2, M. D. Howell1; 1Department of Pediatrics, National Jewish Medical & Research Center, Denver, CO, 2Department of Dermatology and Immunobiology, University of Bonn, Bonn, GERMANY. 2:00 286 Staphylococcal Alpha Toxin Induces IFN-γ in Skin and Blood Derived T Cells of Patients With Atopic Dermatitis K. Breuer, V. Kohlrautz, K. Kempe, A. Kapp, T. Werfel; Department of Dermatology and Allergology, Hannover Medical University, Hannover, GERMANY. 2:15 287 Interaction of Staphylococcus aureus Peptidoglycan With TollLike Receptor 2, but not Platelet Activating Factor Receptor, Promotes TNFα Release From Human Conjunctival Epithelial Cells E. B. Cook1, J. L. Stahl1, N. P. Barney2, F. M. Graziano1; 1Medicine, University of Wisconsin-Madison, Madison, WI, 2Ophthalomology and Visual Sciences, University of Wisconsin-Madison, Madison, WI. 2:30 289 Repeated Topical Exposure to Staphylococcal Enterotoxin B (SEB) Elicits Vigorous IgE Antibody Production and Exacerbates Allergen Induced Skin Inflammation T. Träskbäck, A. Lauerma, M. Majuri, H. Wolff, H. Alenius; Finnish Institute of Occupational Health, Helsinki, FINLAND.

Oral Abstract Session 2605 Saturday, March 20 1:30 PM to 2:45 PM Allergens, Endotoxin and Asthma in Infancy 1:30 290 Cat Ownership in Early Life and Sensitization to Cat at Age 5 Years: A Prospective Study A. Custovic, B. Simpson, P. Kissen, M. Craven, C. Murray, A. Woodcock, A. Simpson; North West Lung Research Centre, Manchester, UNITED KINGDOM. 1:45 291 Risk Factors for Persistent Wheezing in Young Children V. P. L. Ferriani1, J. M. Silva1, A. A. Camara1, K. R. Tobias1, I. S. Macedo1, M. R. Cardoso2, E. Arruda1, T. A. E. Platts-Mills3, L. K. Arruda1; 1School of Medicine of Ribeirao Preto - University of Sao Paulo, Ribeirao Preto, BRAZIL, 2School of Public Health - University of Sao Paulo, Ribeirao Preto, BRAZIL, 3Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA. 2:00 292 Effects of Environmental Endotoxin and Can f1 on Interleukin-10 Responses in Infancy C. L. Reardon1, J. Kohls1, Z. Li2, K. A. Roberg1, E. Anderson1, C. Tisler1, D. DaSilva1, R. Gangnon2, H. Hiemke1, A. H. Liu3, P. A. Eggleston4, R. F. Lemanske, Jr.1, J. E. Gern1; 1Department of Pediatrics, University of Wisconsin Medical School, Madison, WI, 2Department of Bioinformatics, University of Wisconsin Medical School, Madison, WI, 3Department of Pediatrics, National Jewish Medical Research Center, Denver, CO, 4Department of Pediatrics, Johns Hopkins University, Baltimore, MD. 2:15 293 Endotoxin in Inner-City Homes and Atopy and Wheeze in the First Two Years of Life

M. S. Perzanowski1, R. L. Miller1, P. S. Thorne2, B. J. Sheares1, J. C. Correa1, F. P. Perera1, I. F. Goldstein1, G. L. Chew1; 1Columbia’s Center for Children’s Environmental Health, Columbia University, New York, NY, 2University of Iowa College of Public Health, Iowa City, IA. 2:30 294 Parental Reports of Indoor Environmental Exposures in Underserved Populations: Validity and Predictive Utility D. S. Catz1, S. Milan2, A. Mehta-Sampath3, J. N. Tobin1; 1Clinical Directors Network, Inc., New York, NY, 2Center for Interdisciplinary Research on AIDS, Yale School of Medicine, New Haven, CT, 3Radiation and Indoor Air Branch, Environmental Protection Agency Region II, New York, NY.

Oral Abstract Session 2606 Saturday, March 20 1:30 PM to 2:45 PM Food Allergy - Prevalence and Agent 1:30 295 Prevalence of Peanut and Tree Nut (TN) Allergy in the US Determined by a Random Digit Dial Telephone Survey: A Five Year Follow-Up Study S. H. Sicherer1, A. Muñoz-Furlong2, H. A. Sampson1; 1Pediatrics, Mt Sinai School of Medicine, New York, NY, 2Food Allergy and Anaphylaxis Network, Fairfax, VA. 1:45 296 Soybean Oil Is Not Allergenic to Soybean-Allergic Individuals S. L. Taylor1, J. A. Nordlee1, S. H. Sicherer2, H. A. Sampson2, M. B. Levy3, H. Steinman4, R. K. Bush5, P. Vadas6, S. L. Hefle1, F. Rancé7; 1Food Science & Technology, University of Nebraska, Lincoln, NE, 2Mount Sinai School of Medicine, New York, NY, 3Medical College of Wisconsin, Milwaukee, WI, 4Allergy Resources International, Milnerton, SOUTH AFRICA, 5University of Wisconsin Hospital & Clinics, Madison, WI, 6Saint Michael’s Hospital, Toronto, ON, CANADA, 7Hôpital des Enfants, Toulouse, FRANCE. 2:00 297 Immunochemical Analysis of Various Foods and Food Ingredients for Detectable Gluten Content: Implications for WheatAllergic and Celiac Sprue Patients A. L. Lardizabal1, L. M. Niemann2, S. L. Hefle2; 1Food Science and Technology, Food Allergy Research and Resource Program/University of Nebraska-Lincoln, Lincoln, NE, 2Food Science and Technology, Food Allergy Research and Resource Program/University of Nebraska-Lincoln, Lincoln, NE. 2:15 298 Breastfeeding and Food Avoidance Are Ineffective in Preventing Sensitization in High Risk Children G. K. Appelt1, M. Chan-Yeung2, W. T. A. Watson1, H. DimichWard2, A. Ferguson3, J. Manfreda4, A. B. Becker1; 1Pediatric Allergy and Clinical Immunology, University of Manitoba, Winnipeg, MB, CANADA, 2Respiratory Division, University of British Columbia, Vancouver, BC, CANADA, 3Pediatric Allergy, University of British Columbia, Vancouver, BC, CANADA, 4Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, CANADA. 2:30 299 Prevalence of Self-Reported Seafood Allergy in the US A. Muñoz-Furlong1, H. A. Sampson2, S. H. Sicherer2; 1The Food Allergy and Anaphylaxis Network, Fairfax, VA, 2Pediatrics, Mt Sinai School of Medicine, New York, NY.

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Oral Abstract Session 2607 Saturday, March 20 1:30 PM to 2:45 PM Treatment of Inner City Asthma 1:30 300 Patterns of Childhood Asthma Management Practices by Physicians in the Inner City C. M. Patino, K. A. Riekert, A. Bilderback, J. A. Krishnan, G. B. Diette, C. S. Rand; Medicine, Johns Hopkins University, Baltimore, MD. 1:45 301 Predicting Asthma Symptoms in Low-Income Children With Persistent Asthma: The Role of Medication Adherence, Depressive Symptoms and Behavior Problems C. N. Mobley1, M. Celano2, K. Phillips3, J. Linzer3; 1Department of Maternal and Child Health, University of Alabama at Birmingham, School of Public Health, Birmingham, AL, 2Department of Psychiatry and Behavioral Sciences, Emory University, School of Medicine, Atlanta, GA, 3Department of Pediatrics, Emory University, School of Medicine, Atlanta, GA. 2:00 302 Predictors of Control Over Time Among Poor, Inner-City, Children With Asthma J. A. Fifield1, A. Apter2, R. Cushman1, E. Jackson1, J. Twiggs3, J. Sheehan4, J. Burleson4, M. Peele1, S. Reisine5, J. Hepworth1, A. Gilchrist1; 1Family Medicine, University of Connecticut Health Center, Farmington, CT, 2University of Pennsylvania, Philadelphia, PA, 3Kansas State University, Manhattan, KS, 4Community Medicine, University of Connecticut Health Center, Farmington, CT, 5Behavioral Sciences, University of Connecticut Health Center, Farmington, CT. 2:15 303 Asthma Screening Among Inner City Youth and High School Athletes L. Caliguiri1,2, J. Kilby2, W. Light2, J. Gloster1; 1CHASE, Coalition of Health for Asthmatics in Sports and Exercise, Pittsburgh, PA, 2Center for Asthma and Allergy Care, Pittsburgh, PA. 2:30 304 Coping With Asthma Among African Americans: A Focus Group Study G. Mosnaim1, L. Sharp2, L. Grammer2, C. Kohrman3; 1Rush Presbyterian St. Luke’s Medical Center, Chicago, IL, 2Northwestern University School of Medicine, Chicago, IL, 3Community Research and Training Consultant, Chicago, IL.

Oral Abstract Session 2608 Saturday, March 20 1:30 PM to 2:45 PM Mast Cells/Basophils 1:30 305 Differential Modulation of Human Basophil Functions Through PGD2 Receptors DP and CRTH2/DP2 C. Yoshimura-Uchiyama1,2, M. Iikura1, M. Yamaguchi1, H. Nagase1, A. Ishii3, K. Matsushima4, K. Yamamoto1, M. Shichijo5, K. B. Bacon5, K. Hirai6; 1Allergy & Rheumatology, Univ of Tokyo, Tokyo, JAPAN, 2Pediatrics, Univ of Tokyo, Tokyo, JAPAN, 3Laboratory Medicine, Univ of Tokyo, Tokyo, JAPAN, 4Molecular Preventive Medi, Univ of Tokyo, Tokyo, JAPAN, 5Research Center Kyoto, Bayer Yakuhin, Kyoto, JAPAN, 6Bioregulatory Function, Univ of Tokyo, Tokyo, JAPAN.

1:45 306 FcεRI and TLR2-Dependent Cytokine Generation by Human Mast Cells Utilize Both Convergent and Divergent Signaling Pathways S. Bagga1, J. M. Lora2, J. Villeval2, A. J. Coyle2, C. Feng1, J. A. Boyce1; 1Rheumatology, Immunology & Allergy, Brigham & Womens Hospital, Harvard Medical School, Boston, MA, 2Millennium Pharmaceuticals Inc., Cambridge, MA. 2:00 307 Human Mast Cell Tolerance Due to Syk Deficiency; an Unrecognized Mechanism for FceRI Regulation C. Kepley; Virginia Commonwealth University Health Systems, Richmond, VA. 2:15 308 NTAL Phosphorylation Is a Common Event in the Signaling Pathways Initiated by Antigen and Stem Cell Factor (SCF) in Mast Cells S. Iwaki1, C. Tkaczyk1, A. B. Satterthwaite2, P. Draber3, V. Horejsi3, D. D. Metcalfe1, A. M. Gilfillan1; 1Lad/niaid, NIH, Bethesda, MD, 2Department of Internal Medicine and Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX, 3Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, CZECH REPUBLIC. 2:30 309 Relative Expression of Toll-Like Receptor (TLR)-9 Protein in Human Basophils vs. Plasmacytoid Dendritic Cells (PDC): Effects of CpG-ODN on FceRIa mRNA levels J. T. Schroeder, Y. Chen, A. P. Bieneman, K. L. Chichester, E. Siekierski; Department of Medicine, Johns Hopkins University, Baltimore, MD.

Oral Abstract Session 2609 Saturday, March 20 1:30 PM to 2:45 PM Saturday Allied Health Oral Abstract Session 1:30 310 Providing an In-Home Allergen Control Intervention: A Comparison of Behavioral Changes in Inner-City Homes of Children With Asthma K. A. Callahan1, C. S. Rand1, M. M. Grant1, J. M. Curtin-Brosnan2, L. J. Swartz1, G. B. Diette1, P. Breysse2, J. A. Krishnan1, S. Kanchanaraksa2, P. A. Eggleston1; 1School of Medicine, Johns Hopkins University, Baltimore, MD, 2Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD. 1:45 311 Predictors of Indoor Allergen J. Curtin-Brosnan1, T. T. Perry2, R. A. Wood2, C. S. Rand2, K. A. Callahan2, L. J. Swartz2, E. C. Matsui2, S. Kanchanaraksa1, P. A. Eggleston2; 1Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, 2Johns Hopkins University, School of Medicine, Baltimore, MD. 2:00 312 Interdisciplinary Education: Perceptions of the Usefulness of a Clinical Simulation to Promote Learning About Asthma in Children T. K. C. Rodehorst1, S. L. Wilhelm1, L. Jensen2; 1College of Nursing, University of Nebraska Medical Center, Scottsbluff, NE, 2College of Nursing, University of Nebraska Medical Center, Kearney, NE. 2:15 313 The Impact of Asthma Action Plans on Quality of Life and Other Asthma Outcomes K. E. Mudd1, M. E. Bollinger1, M. Donithan2, A. M. Butz3; 1Pediatrics, University of Maryland School of Medicine, Baltimore,

MD, 2Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 3Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. 2:30 314 CRS, a Clinical Registration System B. A. Miller1, M. E. Dennis1, M. Muncy2; 1Dept. Internal Medicine, Div. of Allergy/Immunology, University of Kentucky, Lexington, KY, 2Hensley, Elam & Associates, Lexington, KY.

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Poster Session 3401 Sunday, March 21 11:00 AM to 12:00 PM Immunotherapy 315 An Experimental Animal Model for Investigation of the Influence of Oral Tolerance on Airway Hyperreactivity A. Nakonechna1, H. Renz2, M. Wegmann2, G. Drannik1, L. M. DuBuske3; 1National Medical University, Kiev, UKRAINE, 2Philipps University Marburg, Marburg, GERMANY, 3Immunology Research Institute of New England, Fitchburg, MA. 316 Serum IgA Response to Grass Pollen During Allergen-Injection Immunotherapy for Seasonal Rhinitis C. Pilette, K. T. Nouri-Aria, S. R. Durham; Upper Respiratory Medicine, Imperial College London, London, UNITED KINGDOM. 317 Alutard SQ Grass Demonstrates Clinical Efficacy in Subjects With Seasonal Allergic Rhinoconjunctivitis in a Large-Scale Double-Blind Placebo Controlled Study of Specific Allergy Vaccination (the AVANZ Study) A. J. Frew1, R. J. Powell2, S. R. Durham3; 1Southampton General Hospital, Southampton, UNITED KINGDOM, 2University Hospital, Nottingham, UNITED KINGDOM, 3National Heart and Lung Institute, London, UNITED KINGDOM. 318 Long-Lasting Effect of Sublingual Ragweed Immunotherapy: A 5 Year Prospective Study D. Maria, M. Dervaderics; Dervaderics BT, Kronberg, GERMANY. 319 T Cell Expression of CXCR1 Is a Marker of Atopic Allergy and Is Downregulated Following Grass Pollen Immunotherapy J. N. Francis1, S. J. Till1, C. M. Lloyd2, I. Sabroe3, S. R. Durham1; 1Upper Respiratory Medicine, Imperial College, London, UNITED KINGDOM, 2Leukocyte Biology, Imperial College, London, UNITED KINGDOM, 3Section of Functional Genomics, University of Sheffield, Sheffield, UNITED KINGDOM. 320 Grass Pollen Immunotherapy (IT) Decreases IL-9 mRNA Expressing Cells in the Nasal Mucosa During the Pollen Season K. T. Nouri-Aria, C. Pilette, M. R. Jacobson, D. R. Wilson, S. R. Durham; Upper Respiratory Medicine, National Heart & Lung Institute @Imperial College London, London, UNITED KINGDOM. 321 The Blocking Activity of Birch Pollen Specific Immunotherapy Induced IgG4 Is Not Qualitatively Superior to That of Other IgG Subclasses A. M. Ejrnaes1,2, U. Bodtger3, J. N. Larsen1, M. Svenson2; 1ALKAbelló A/S, Hørsholm, DENMARK, 2Institute for Inflammation Research, Rigshospitalet University Hospital, Copenhagen, DENMARK, 3Allergy Unit, Rigshospitalet University Hospital, Copenhagen, DENMARK. 322 High Dose Sublingual Immunotherapy: Economic Evaluation From an Italian Observational Database Study M. Bassi1, P. Berto2, C. Incorvaia3, F. Frati4, L. A. Magni1, C. Ortolani5; 1Pediatrics, Rho Hospital, Rho, ITALY, 2PBE Consulting, Verona, ITALY, 3Allergy Unit, ICP Hospital, Milan, ITALY, 4Obstetrics, Ginaecology and Pediatrics, University of Perugia, Perugia, ITALY, 5Allergy Centre, Niguarda Hospital, Milan, ITALY.

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Comparisons Between Injection and Sublingual Immunotherapy for Rhinitis and Asthma in Allergic Children to House Dust Mite or Parietaria Pollen. A Case Controlled Study G. B. Pajno, D. Vita, L. Caminiti, G. Di Dio, S. Carcione, G. Barberio; Department of Pediatrics - Allergy Unit, University of Messina, Messina, ITALY. Aluminium Hydroxide Promotes Th1 Responses by Peripheral Blood-Mononuclear Cells (PBMCs) Obtained From Grass Pollen-Allergic Subjects L. K. Wilcock, J. N. Francis, S. R. Durham; Upper Respiratory Medicine, Imperial College, London, UNITED KINGDOM. Expression, in Basophils, of Activation Molecule CD63 in Patients With Mites Rhinitis Submitted to Specific Immunotherapy A. C. S. Melo, M. Pereira Santos, M. Branco Ferreira, M. Palma Carlos, A. Palma Carlos; C.h.i.u.l., FAC. MED. LISBON, Lisbon, PORTUGAL. Peptide-Based Allergen Immunotherapy Is Associated With Improvements in Symptoms of Rhinitis C. Alexander, M. Tarzi, M. Larché, A. B. Kay; Allergy and Clinical Immunology, Imperial College, NHLI Division, London, UNITED KINGDOM. Safety and Tolerability of Ultra-Rush (20 minutes) Allergoid Sublingual Immunotherapy in Patients With Allergic Rhinitis and/or Asthma E. Gammeri; Azienda U.S.L. 5, Osp. Centro Prev. Malattie Respiratorie, Messina, ITALY. Tolerability of Sublingual Immunotherapy With Monomeric Allergoid in Allergic Sensitizations to House Dust Mite, Parietaria and Grass A. Silvestris, P. Camassa, M. Lomuto; U.O. Dermatologia Servizio di Allergologia, Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), ITALY. Efficacy and Safety of Sublingual Immunotherapy With High Dose House Dust Mite Extract in Asthmatic Children - A Multicenter Randomized Double-Blind, and Placebo-Controlled Study C. Niu1, J. Wang2, J. Huang3, K. Lue4, W. Chen5; 1Pediatric Pulmonology, Chang Gung Children’s Hospital, Kaohsiung, Taiwan, Kaohsiung, TAIWAN REPUBLIC OF CHINA, 2Pediatrics, National Chen Kung University Hospital, Tainan, TAIWAN REPUBLIC OF CHINA, 3Pediatrics, Chang Gung Children’s Hospital, Taipei, Taiwan, Taipei, TAIWAN REPUBLIC OF CHINA, 4Pediatrics, Chun-Shan Medical university, Taichung, TAIWAN REPUBLIC OF CHINA, 5Pediatrics, Kaohsiung Medical University, Kaohsiung, TAIWAN REPUBLIC OF CHINA. Efficacy and Safety of Subcutaneous and Sublingual Immunotherapy in Birch Pollinosis M. Mauro1, M. Russello1, C. Incorvaia2, E. D’Ingianna1, G. Gazzola1; 1Allergy Unit, Ospedale Sant’Anna, Como, ITALY, 2Allergy Unit, Ospedale ICP, Milan, ITALY. Comparison Of Immunological Changes Induced by Sublingual and Subcutaneous Specific Immunotherapy in Children With Allergic Respiratory Disease C. Mayorga1, J. L. Corzo2, C. Antunez1, M. J. Torres3, J. A. Cornejo-Garcia1, R. Santos2, A. Jurado2, M. Blanca3; 1Research Laboratory, Carlos Haya Hospital, Málaga, SPAIN, 2Allergy Pediatric Unit, Carlos Haya Hospital, Málaga, SPAIN, 3Allergy Service, Carlos Haya Hospital, Málaga, SPAIN. Outcome of Bee and Wasp Venom Immunotherapy (VIT) in a Major Allergy Center in the UK K. K. Jones, P. Fitzharris, A. Kerlin, T. H. Lee, C. J. Corrigan; Asthma, Allergy & Respiratory Science, Guy’s, King’s & St. Thomas’ School of Medicine, London, UNITED KINGDOM. Allergen Immunotherapy Increases Suppressive Activity by CD4+CD25-, IL-10 Producing T Cells, But Does Not Affect Suppression by CD4+CD25+ T Cells

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E. M. Ling1, M. Calderon2, D. Nguyen1, K. Powrie3, S. R. Durham2, D. S. Robinson1; 1Allergy and Leukocyte Biology, Imperial College London, London, UNITED KINGDOM, 2Upper Respiratory Medicine, Imperial College London, London, UNITED KINGDOM, 3Allergy Clinic, St Mary’s Hospital, London, UNITED KINGDOM. Adhesion Molecules and Efficacy of Specific Immunotherapy M. Pereira Santos, A. Melo, M. Branco Ferreira, M. Palma Carlos, A. Palma Carlos; C.h.i.u.l., FAC. MED. LISBON, Lisbon, PORTUGAL. A New and Safer Method for Preserving Allergen Stability in Human Vaccines S. Kagen1, R. Muthiah1, J. Holinbeck2; 1Kagen Allergy Clinic, Appleton, WI, 2Biology, Lawrence University, Appleton, WI. Comparison of Allergic Indices Between Monosensitized and Polysensitized Patients in Childhood Asthma T. Song, E. Kim, B. Kwon, S. Choi, M. Sohn, K. Kim; Pediatrics, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA. A Double-Blind, Placebo-Controlled Study of House Dust Mite Immunotherapy in Asthmatic Patients in China H. Wang1, C. Zhang1, B. Sun1, S. Li1, Y. He1, N. Zhong1, X. Lin2, W. Sun2, P. Chen2, C. Hao3, Z. Hou3, J. Sheng3, A. Y. Wu4; 1Guangzhou Institute of Respiratory Diseases, Guangzhou, CHINA, 2Shenyang General Military Hospital, Shenyang, CHINA, 3Suzhou Children’s Hospital, Suzhou, CHINA, 4University of Hong Kong, Pokfulam, HONG KONG SPECIAL ADMINISTRATIVE REGION OF CHINA. Systemic Reactions in Multiple Aeroallergen Rush Immunotherapy: A Two-Year Follow-Up S. Laurie; Dallas Allergy and Asthma Center, Dallas, TX. Tolerability of the Allergoid Sublingual Immunotherapy With a Monomeric Allergoid in Patients With Allergic Rhinitis and/or Asthma R. M. Scolozzi; Centro Allergologico, Sezione di Medicina Interna I, Azienda Ospedaliera Universitaria, Ferrara, ITALY. Efficacy of Allergoid Sublingual Immunotherapy in Children With Asthma and/or Allergic Rhinoconjunctivitis: Comparison Study With Drugs C. Melaranci, M. C. Matteoli; Pediatria, Ospedale Pediatrico Bambino Gesù, Presidio di Santa Marinella, Roma, ITALY. Dose Adjustments Are Unnecessary for Local Reactions Occurring at Immunotherapy Satellite Clinics M. S. Tankersley; Department of Allergy, Asthma and Immunology, Third Medical Group, Anchorage, AK. Efficacy of Allergoid Sublingual Immunotherapy in Patients With Allergic Bronchial Asthma to House Dust Mite U. Orefice; Pneumological Dept., Ospedale Civile, Udine, ITALY. Assessment of Patient Knowledge on Immunotherapy Before and After an Educational Intervention: A Comparison of Two Methods M. M. Rathkopf, D. L. Proffer, J. M. Quinn, D. C. Napoli; Department of Allergy and Immunology, Wilford Hall Medical Center, San Antonio, TX. The Effect of Treatment With HLA-DR Based T Cell Peptides Derived From Phospholipase A2 on Late-Phase Skin Reactions and T Cell Function in Subjects With Mild Honeybee Allergy M. Tarzi1, M. Larché1, A. B. Kay1, C. Texier2, B. Maillière2; 1Allergy and Clinical Immunology, Imperial College, NHLI Division, London, UNITED KINGDOM, 2Protein Engineering and Research, CEA-Saclay, Gif sur Yvette, FRANCE. Exhaled Nitric Oxide Levels Rise and Then Fall During the First Three Months of Immunotherapy C. Dinakar1, A. Ziegler1, T. J. Van Osdol1, C. S. Barnes2, P. J. Dowling1; 1Section of Allergy/Asthma/Immunology, Department of Pediatrics, Univ of Missouri at Kansas City, Kansas City, MO,

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Poster Session 3402 Sunday, March 21 11:00 AM to 12:00 PM Corticosteroid Treatment of Asthma 346 Safety of Fluticasone Propionate HFA in Treating Children 411 Years of Age With Asthma J. Given1, E. Kent2, D. Gossage3, D. Clements4, C. Scott4, W. Wu4, C. Crim4; 1Allergy and Respiratory Center, Canton, OH, 2Timber Lane Allergy and Asthma Research, So. Burlington, VT, 3The Allergy, Asthma and Sinus Center, Knoxville, TN, 4GlaxoSmithKline, Research Triangle Park, NC. 347 Fluticasone Propionate HFA Improves Asthma Control in Children Aged 4 to 11 Years With Asthma A. Levy1, J. Condemi2, L. Landwehr3, D. Clements4, C. Scott4, W. Wu4, C. Crim4; 1Foothills Allergy and Asthma Associates, Spartanburg, SC, 2Allergy Asthma Immunology of Rochester, Rochester, NY, 3Clinical Research of the Ozarks, Warrensburg, MO, 4GlaxoSmithKline, Research Triangle Park, NC. 348 Fluticasone Propionate (FP) Was Superior to Montelukast (MON) in Producing at Least a 2-Step Improvement in Asthma Severity in Children 6-12 Years of Age W. R. Lincourt, C. Crim, K. M. Hanson, L. D. Edwards; Respiratory, GlaxoSmithKline Inc, Research Triangle Park, NC. 349 Ciclesonide Has Minimal Oropharyngeal Side Effects in the Treatment of Patients With Moderate-to-Severe Asthma J. A. Bernstein1, M. J. Noonan2, C. Rim3, J. Fish3, S. Kundu3, J. Williams3, D. D. Banerji3, P. Hamedani3; 1Bernstein Clinical Research Center, Cincinnati, OH, 2Allergy Associates Research Center, Portland, OR, 3Aventis Pharmaceuticals, Bridgewater, NJ. 351 The Effect of Oral Corticosteroids and High-Dose Combination Therapy on Achieving Control of Refractory Asthma J. Bousquet1, E. Bateman2, H. Boushey3, W. Busse4, T. Clark5, R. Pauwels6, S. Pedersen7; 1Hospital Arnaud De Villeneuve, Montpellier, FRANCE, 2UCT Lung Institute, University of Cape Town, Cape Town, SOUTH AFRICA, 3University of California, San Francisco, CA, 4Department of Medicine, University of Wisconsin, Madison, WI, 5National Heart and Lung Institute, Imperial College, London, UNITED KINGDOM, 6Ghent University Hospital, Ghent, BELGIUM, 7University of Southern Denmark, Kolding Hospital, Kolding, DENMARK. 352 Early Intervention With Increased Inhaled Corticosteroids (ICS) for Controlling of Acute Asthma Exacerbations Improves Outcomes R. Wachs, S. McGeady, E. Yousef; Division of Allergy and Clinical Immunology, Thomas Jefferson University, Wilmington, DE. 353 Measurement of Peak Inspiratory Flow Rates With an InCheck Meter to Identify Preschool Children’s Ability to Use Dry Powder Inhalers; Diskus and Turbuhaler Y. Adachi1, Y. S. Adachi1, T. Itazawa1, J. Yamamoto2, G. Murakami1, T. Miyawaki1; 1Department of Pediatrics, Toyama Medical & Pharmaceutical University, Toyama, JAPAN, 2Department of Pediatrics, Toyama Red Cross Hospital, Toyama, JAPAN. 355 Cross-Sectional Assessment of Persistency With Inhaled Corticosteroids (ICS) in Pediatric Asthmatic Patients Aged 8 Years or Younger M. Johnsrud1, P. A. Patel2, B. Parasuraman2, L. McDermott2; 1The University of Texas at Austin, Austin, TX, 2AstraZeneca, Wilmington, DE. 356 Achieving GINA/NIH Guideline-Based Asthma Control With Salmeterol/Fluticasone Compared With Fluticasone Alone: The Results of the GOAL Study

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W. W. Busse1, E. Bateman2, H. Boushey3, J. Bousquet4, T. Clark5, R. Pauwels6, S. Pedersen7; 1Medicine/Allergy and Immunology, University of Wisconsin Medical School, Madison, WI, 2UCT Lung Institute, University of Cape Town, Cape Town, SOUTH AFRICA, 3University of California, San Francisco, CA, 4Hospital Arnaud de Villeneuve, Montpellier, FRANCE, 5National Heart and Lung Institute, Imperial College, London, UNITED KINGDOM, 6Ghent University Hospital, Ghent, BELGIUM, 7Kolding Hospital, University of Southern Denmark, Kolding, DENMARK. Improvements in Asthma Outcomes Following 1 Year of Treatment With Salmeterol/Fluticasone or Fluticasone Alone When Stepped Up to Achieve Guideline-Defined Total Control H. Boushey1, E. Bateman2, J. Bousquet3, W. Busse4, T. Clark5, R. Pauwels6, S. Pedersen7; 1University of California, San Francisco, CA, 2UCT Lung Institute, University of Cape Town, Cape Town, SOUTH AFRICA, 3Hospital Arnaud De Villeneuve, Montpellier, FRANCE, 4University of Wisconsin Medical School, Madison, WI, 5National Heart and Lung Institute, Imperial College, London, UNITED KINGDOM, 6Ghent University Hospital, Ghent, BELGIUM, 7University of Southern Denmark, Kolding Hospital, Kolding, DENMARK. Degradation of Mometasone Furoate in the Lung S. Sahasranaman1, M. Issar1, G. Toth2, G. Horvath2, G. Hochhaus1; 1Pharmaceutics, University of Florida, Gainesville, FL, 2Structure Elucidation Group, IVAX Drug Research Institute, Budapest, HUNGARY. Salmeterol/Fluticasone and Fluticasone Alone Are Well Tolerated Over 1 Year of Treatment Stepped-Up to Achieve Total Control: Safety Results of the GOAL Study T. Clark1, E. Bateman2, H. Boushey3, J. Bousquet4, W. Busse5, R. Pauwels6, S. Pedersen7; 1National Heart and Lung Institute, Imperial College, London, UNITED KINGDOM, 2UCT Lung Institute, University of Cape Town, Cape Town, SOUTH AFRICA, 3University of California, San Francisco, CA, 4Hospital Arnaud De Villeneuve, Montpellier, FRANCE, 5Department of Medicine, University of Wisconsin, Madison, WI, 6Ghent University Hospital, Ghent, BELGIUM, 7University of Southern Denmark, Kolding Hospital, Kolding, DENMARK. Single Inhaler Therapy With Budesonide/Formoterol Provides Superior Asthma Control Compared With Fixed Dosing With Budesonide Plus Terbutaline As Needed K. F. Rabe1, E. Pizzichini2, B. Ställberg3, S. Romero4, A. Balanzat5, T. Soerensen6, T. Atienza7; 1Pulmonology, Leiden University Medical Center, 2333 ZA Leiden, NETHERLANDS, 2University Hospital of Florianopolis, Florianopolis, BRAZIL, 3Uppsala University, Uppsala, SWEDEN, 4Hospital General de Alicante, Alicante, SPAIN, 5Hospital de Clinicas ‘Jose de San Martin’, Buenos Aires, ARGENTINA, 6Private Practice, Bymidten, DENMARK, 7Mary Mediatrix Medical Center, Lipa City, PHILIPPINES. Glucocorticoids Suppress Goblet Cell Metaplasia in Natural and Experimental Asthma E. Y. Kim1,2, J. Kim1, J. D. Morton1,2, S. Swanson1, A. Patel1,3, M. Castro1, M. J. Holtzman2,4; 1Division of Pulmonary and Critical Care, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, 2Immunology Program, Washington University School of Medicine, Saint Louis, MO, 3Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO, 4Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Cell Biology, Washington University School of Medicine, Saint Louis, MO. Single Inhaler Therapy With Budesonide/Formoterol Reduces the Risk of Severe Exacerbations Compared With Budesonide Plus Terbutaline As Needed in Patients With Asthma R. Scicchitano1, R. Aalbers2, D. Ukena3, A. I. Manjra4, L. Fouquert5, S. Centanni6, L. Boulet7; 1Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, AUSTRALIA, 2Depart-

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ment of Pulmonology, Martini Hospital, Groningen, NETHERLANDS, 3University Hospital, Homburg, GERMANY, 4Westville Hospital, Westville, Durban, SOUTH AFRICA, 5Medical Practice, Grasse, FRANCE, 6Respiratory Unit, San Paolo Hospital, University of Milan, Milan, ITALY, 7The Laval University Cardiothoracic Institute, Laval Hospital, Quebec City, PQ, CANADA. Low Fluticasone Propionate (FP) Exposure and Effects on Cortisol for CFC-Free Metered Dose Inhalers (MDI) in Healthy Subjects and Asthmatics R. L. Kunka; Clinical Pharmacology & Discovery Medicine, GlaxoSmithKline, Research Triangle Park, NC. Factors Influencing the Responsiveness to High Dose Inhaled Glucocorticoids in Patients With Asthma A. S. Jang, J. H. Lee, S. W. Park, C. S. Park; Allergy and Pulmonology, Soonchunhyang University Hospital, Bucheon-si, Gyeonngi-do, REPUBLIC OF KOREA. Asthma Control With Fluticasone Propionate/Salmeterol 100/50µg Diskus® Versus Montelukast in Patients Previously Receiving Short-Acting Beta2-Agonists W. Calhoun1, L. Sutton2, A. Emmett2, P. Dorinsky2; 1Asthma, Allergy and Airway Research Center, University of Pittsburgh, Pittsburgh, PA, 2GlaxoSmithKline, Research Triangle Park, NC. The Safety and Effectiveness of Once Daily Administration of Fluticasone Propionate/Salmeterol 250/50µg P. Dorinsky, L. Schoaf, K. House, A. VanderMeer; GlaxoSmithKline, Research Triangle Park, NC. Comparison Of Effectiveness Between Nebulized Budesonide Plus Albuterol Versus Albuterol Alone in Children With Moderate Acute Asthma M. V. Blandon, M. A. Rosas, B. E. Del Rio, J. J. Sienra; Pediatric Allergy, Asthma and Immunology, Hospital Infantil de Mexico Federico Gomez, Mexico City, MEXICO. Fluticasone Propionate Administered Via Metered-Dose Inhaler With Valved Holding Chamber and Attached Facemask Is Effective in Improving Asthma Control by Producing At Least a 2-Step Improvement in Asthma Staging in PreSchool Age Children With Asthma C. Crim1, C. A. Scott1, C. J. Maden2, W. Wu1; 1GlaxoSmithKline, Inc., Research Triangle Park, NC, 2GlaxoSmithKline, Inc., Greenford, UNITED KINGDOM. Differences in Selectivity of Inhaled Glucocorticoids (IGCs) to the Glucocorticoid Receptors (GR) M. Issar, S. Sahasranaman, G. Hochhaus; Pharmaceutics, University of Florida, Gainesville, FL. Virus Specific Efficacy of Systemic Glucocorticoid in Wheezing Children T. Jartti1, P. Lehtinen2, T. Vanto2, T. Vuorinen3, M. Mäkelä1, O. Ruuskanen2; 1Department of Pediatrics, Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, FINLAND, 2Department of Pediatrics, Turku University Hospital, Turku, FINLAND, 3Department of Virology, University of Turku, Turku, FINLAND. Chronic Dosing Effects of Mediator Antagonists in Corticosteroid Treated Atopic Asthmatic Patients C. M. Jackson, D. K. C. Lee, K. Haggart, T. C. Fardon, B. J. Lipworth; Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UNITED KINGDOM. Effects of Hydrofluoroalkane Formulations of Ciclesonide 320µg Once Daily Versus Fluticasone Propionate 220µg Twice Daily on Methacholine Hyperresponsiveness in Mild-to-Moderate Persistent Asthma T. C. Fardon, D. K. C. Lee, R. D. Gray, G. P. Currie, K. Haggart, C. E. Bates, B. J. Lipworth; Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UNITED KINGDOM. Lower-Leg Growth Rate and HPA-Axis Function in Children

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With Asthma During Treatment With Inhaled Ciclesonide L. Agertoft, S. Pedersen; Department of Pediatrics, University of Southern Denmark, Kolding, DENMARK. 375 Efficacy of Inhaled Budesonide (Pulmicort Turbuhaler®) in Recent-Onset Moderate to Severe Persistent Asthma W. W. Busse1, T. Uryniak2; 1Division of Allergy and Immunology, University of Wisconsin Medical School, Madison, WI, 2Biostatistics Project Team, AstraZeneca LP, Wilmington, DE. 376 Equivalent Pharmacokinetics of the Active Metabolite of Ciclesonide With and Without Use of a Spacer for Inhalation A. Drollmann1, R. Nave1, V. W. Steinijans1, T. D. Bethke1, E. Baumgärtner2; 1ALTANA Pharma AG, Konstanz, GERMANY, 2Quintiles GmbH, Freiburg, GERMANY. 377 Inhaled Corticosteroid (ICS) Prescribing Patterns for Pregnant Women With Asthma: US Allergists and Pulmonologists Compared With Primary Care Physicians N. K. Ostrom1, P. Park2, L. O’Dowd2; 1Allergy and Asthma Medical Group and Research Center, San Diego, CA, 2AstraZeneca LP, Wilmington, DE. 378 Evaluation of Basal and Dynamic Measures of Adrenocortical Activity With High Dose Inhaled Fluticasone in Asthmatic and Healthy Subjects C. E. Bates, D. K. C. Lee, G. P. Currie, L. M. Cowan, L. C. McFarlane, B. J. Lipworth; Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UNITED KINGDOM. 379 The Effectiveness of Once-Daily Dosing of Inhaled Budesonide in Maintaining Control of Childhood Asthma F. Cetinkaya; Pediatrics, Sisli Etfal Hospital, Istanbul, TURKEY. 380 GATA-3 Nuclear Import Plays a Critical Role in Regulating Th2 Cytokine Gene Expression: Effects of Fluticasone I. M. Adcock, O. S. Usmani, P. J. Barnes, K. Maneechotesuwan; Thoracic Medicine, NHLI, Imperial College London, London, UNITED KINGDOM. 380A Safety of Once-Daily Budesonide Inhalation Suspension (Pulmicort Respules®) in Infants Aged 6 to 12 Months W. E. Berger1, P. Y. Qaqundah2, K. Blake3, J. Rodriguez-Santana4, A. Irani5, J. Xu6, M. Goldman6; 1Allergy and Asthma Associates of Southern California, Mission Viejo, CA, 2Pediatric Care Medical Group, Inc., Huntington Beach, CA, 3Nemours Children’s Clinic, Jacksonville, FL, 4Pediatric Pulmonary and Critical Care, Pediatric Pulmonary Program of San Juan, San Juan, MEXICO, 5Virginia Commonwealth University, Richmond, VA, 6AstraZeneca, LP, Wilmington, DE.

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3403 Sunday, March 21 11:00 AM to 12:00 PM Immunodeficiency II 381 IgE and Allergic Diseases in HIV-Infected Adults Randomized to IL-2 and Antiretrovirals (ARV) Versus ARV Alone J. Ananworanich1, H. Chantapakul2, S. Teeratakulpisarn1, S. Ubolyam1, U. Siangphoe1, K. Ruxrungtham1,2; 1HIV-NAT, The Thai Red Cross AIDS Research Center, Bangkok, THAILAND, 2Allergy and Immunology, Chulalongkorn University Hospital, Bangkok, THAILAND. 382 Demodicosis: An Unusual Presentation of Small Lymphocytic Lymphoma M. Rawal1, A. Tiliakos2, R. W. Hostoffer, Jr.1; 1Pediatrics, Case Western Reserve University, Cleveland, OH, 2Kirksville College Of Osteopathic Medicine, Kirksville, MO. 383 Analysis of Headaches Associated With Gammaglobulin Infusion P. Ogbogu, R. W. Hostoffer, Jr.; Pediatrics, Case Western Reserve University, Cleveland, OH.

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Hyper-IgE Syndrome, or Not H. Tcheurekdjian, R. W. Hostoffer, Jr.; Pediatrics, Case Western Reserve University, Cleveland, OH. Clinical Course of Concurrent Lymphocytic Interstitial Pneumonia and Common Variable Immunodeficiency E. R. Scannell1, M. B. Fasano2, M. Larj2; 1Department of Pediatrics, Wake Forest University Baptist Medical Center, WinstonSalem, NC, 2Department of Medicine, Wake Forest University Baptist Medical Center, Winston-Salem, NC. Prophylactic Intravenous Immunoglobulin (IVIG) in Patients With Chronic Lymphatic Leukemia (CLL) & Secondary Hypogammaglobulinemia Improve the Morbidity & Mortality Outcomes M. Ishaq; Allergy, Immunology, Al-Junaid Hospital, Nowshera, PAKISTAN. Acquired IgG Subclass Deficiency - A Gene Mutation? O. O. Raines, A. L. Cosby; Sneeze, Wheeze & Itch Associates, Normal, IL. New Role of IgE V. I. Kvitash; Family & Community Medicine, UCSF, San Francisco, CA. Mannose-Binding Lectin (MBL) Deficiency as a Cause of Worsening Primary Immunodeficiency S. Roy1, N. Wasserbauer2, R. W. Hostoffer, Jr.2; 1Medicine, Case Western Reserve University, Cleveland, OH, 2Pediatrics, Case Western Reserve University, Cleveland, OH. Mycobacterium simiae Infection in a Patient With Common Variable Immunodeficiency R. Arora1, L. Hagan1, N. G. Conger2; 1Allergy/Immunology, Wilford Hall Medical Center, San Antonio, TX, 2Infectious Disease, Wilford Hall Medical Center, San Antonio, TX. Long-Term Follow-Up of a Patient With Intestinal and Pulmonary Lymphangiectasia and Acquired Humoral and Cellular Immunodeficiency W. T. Corder, M. B. Hogan, J. E. Welch, N. W. Wilson; Pediatrics, West Virginia University School of Medicine, Morgantown, WV. Wiskott-Aldrich Syndrome (WAS) With Renal Failure: To Transplant or Not To S. Mathew; Pediatrics, University of New Mexico, Albuquerque, NM. Successful Seven-Day Efavirenz Desensitization Protocol in Two HIV-Positive Patients B. Werner1, M. Burke2, I. Yust1; 1Clinical Immunology Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, ISRAEL, 2Clinical immunology unit, Tel Aviv Sourasky Medical Center, Tel Aviv, ISRAEL. HIV-1 Nef Decreases CXCR4 Expression on CD4+ T-Lymphocytes W. Kamchaisatian, S. Haraguchi, R. A. Good, N. K. Day, P. Emmanuel, J. W. Sleasman, N. Tangsinmankong; Pediatrics, All Children’s Hospital/University of South Florida, St. Petersburg, FL. Transient Hypogammaglobulinemia in a Child With Multiple Infections and Dysmorphic Features M. B. Castro1, N. Mathur1, R. Wallerstein2, H. J. Moallem1; 1Division of Allergy & Immunology, SUNY Downstate Medical Center, Brooklyn, NY, 2Division of Genetics, SUNY Downstate Medical Center, Brooklyn, NY. Comparative Clinical Morbidity of an (Autosomal) Agammaglobulinemic Female and Bruton’s XLA L. G. Scott1, C. M. Bowman1, R. B. Pillai1, C. A. Little1, P. M. Scibielski1, A. F. Finn, Jr.2, F. M. Schaffer1,2; 1Pediatric Pulmonary, Allergy and Immunology, Medical University of South Carolina, Charleston, SC, 2National Allergy, Asthma, and Urticaria Centers, Charleston, SC. Common Variable Immune Deficiency With Gastrointestinal Graft Versus Host Disease

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T. R. Kreil1, G. Poelsler1, W. Teschner2, H. Schwarz2; 1Pathogen Safety, Baxter BioScience, Vienna, AUSTRIA, 2Research & Development, Baxter BioScience, Vienna, AUSTRIA.

Poster Session 3404 Sunday, March 21 11:00 AM to 12:00 PM Autoimmunity 411 Proinflammatory Cytokines Modulates Expression of Novel Isoforms of PM/Scl-75 Transcripts Through Alternative Splicing: Pathogenic Role in Enhancing Autoantigen Immunogenicity in Idiopathic Inflammatory Myositis B. Ng, Y. Yan, D. P. Huston, X. Yang; Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX. 412 Are Storage Conditions of the Substrate Responsible for the Variations of Immunofluorescent Perinuclear Antineutrophil Cytoplasmic Antibodies (pANCA) Pattern? D. Zauli, A. Grassi, G. Vukatana, G. Ballardini, P. Terlizzi, F. B. Bianchi; Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, Italy, Bologna, ITALY. 413 Neonatal Microscopic Polyangiitis Secondary to Transfer of Maternal MPO-ANCA Resulting in Neonatal Pulmonary Hemorrhage and Renal Involvement P. J. Bansal1,2, M. C. Tobin1,2, R. Kimura3; 1Immunology/Microbiology, Rush University Medical Center, Chicago, IL, 2Pediatrics, Cook County Hospital, Chicago, IL, 3Pediatrics, Rush University, Chicago, IL. 414 T Cell Autoimmunity Mediates Experimental Autoimmune Hearing Loss C. A. Solares1, A. E. Edling2, K. Hirose1, G. B. Hughes1, V. K. Tuohy2; 1Otolaryngology, Cleveland Clinic Foundation, Cleveland, OH, 2Immunology, Cleveland Clinic Foundation, Cleveland, OH. 415 Churg Strauss Syndrome in the Absence of Asthma S. E. Bagenstose, D. I. Bernstein, I. L. Bernstein; Immunology Allergy, University of Cincinnati, Cincinnati, OH. 416 Role of Leptin in Autoimmune Arthritis S. M. De Silva1, X. Zhang2, D. Huston1, S. Han2, B. Zheng2; 1Allergy/Immunology and Rheumatology, Baylor College of Medicine, Houston, TX, 2Immunology, Baylor College of Medicine, Houston, TX. 417 Reconstitution of Immunity After Autologous CD34 Cell Transplantation for Autoimmune Diseases J. Storek, Z. Zhao, P. A. McSweeney, R. A. Nash, K. M. Sullivan, D. E. Furst, G. A. Kraft, M. H. Wener; University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA. 418 Wegener’s Granulomatosis in a 16-Year-Old Girl N. Mathur1, M. Castro2, C. Bowser1, H. J. Moallem1; 1Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY, 2Medicine, SUNY Downstate Medical Center, Brooklyn, NY. 419 Cyclosporine Treatment for Autoimmune Sensorineural Hearing Loss A. Z. Hatab1, B. J. Gantz2, Z. K. Ballas1; 1Allergy-Immunology, University of Iowa Hospitals and Clinics and VA Medical Center, Iowa City, IA, 2Otolaryngology–Head and Neck Surgery, University of Iowa Hospitals and Clinics and VA Medical Center, Iowa City, IA. 420 Idiopathic Fibrosclerosis Presenting as Angioedema and Upper Airway Obstruction W. Maek-a-nantawat, J. Klaewsongkram, K. Ruxrungtham, H. Chantaphakul; Department of Medicine, Division of Allergy and Clinical Immunology, Chulalongkorn University, Bangkok, THAILAND. 421 Induction of Allergy and Autoreactivity After Immunization With a Foreign Allergen and the Respective Autoantigen

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J. Venglarcik, III1, L. Seidu1, R. W. Hostoffer, Jr.2; 1Pediatrics, Northeastern University College of Medicine, Rootstown, OH, 2Pediatrics, Case Western Reserve University, Cleveland, OH. Sarcoidosis in a Patient With Common Variable Immunodeficiency I. Veksler Offengenden1, P. F. Maloney2, A. M. Szema1; 1Division of Allergy and Clinical Immunology, SUNY Stony Brook, Stony Brook, NY, 2Division of Allergy and Immunology, SUNY Stony Brook, Stony Brook, NY. Immune Dysfunction in Camurati-Engelmann Disease E. Lu1,2, Z. K. Ballas1,2; 1Department of Internal Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, 2Iowa City VA Medical Center, Iowa City, IA. Atypical Kawasaki Disease (KD) in an HIV-Infected Adolescent O. Belostotsky1, D. Chowdhury2, S. J. Schuval1; 1AllergyImmunology, Long Island Jewish Medical Ctr., New Hyde Park, NY, 2Pediatric Cardiology, Long Island Jewish Medical Ctr., New Hyde Park, NY. Asymptomatic Cryptosporidiosis With Atypical Cholangitis and Eosinophilic Hepatitis in X-Linked Hyper-IgM Syndrome (XHIM) H. Reddy1, B. S. Reid2, L. M. Noroski1, M. R. Coyne1, H. M. Rosenblatt1; 1Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, 2Pediatric Digestive Disease Specialists, Houston, TX. Family Members of Patients With Selective IgA Deficiency Should Be Routinely Screened for Primary Immunodeficiency E. J. Schenkel, K. A. Holdren; Valley Allergy and Asthma Treatment Center, Easton, PA. Rosai-Dorfman Disease: A Case Report Associated With Oral Papillomatosis and Severe Lymphopenia L. B. Moreno, M. A. Cavuoto, B. Kaplan; North Shore-Long Island Jewish Health System, New Hyde Park, NY. Common Variable Immunodeficiency in a Six-Year-Old Boy With Sarcoidosis T. N. Tran1, P. F. Maloney1, L. Romard2, C. T. Kier2; 1Division of Allergy & Clinical Immunology, SUNY-Stony Brook Hospital, Stony Brook, NY, 2Division of Pediatric Pulmonary, Allergy, and Immunology, SUNY-Stony Brook Hospital, Stony Brook, NY. HIV-Related Risk Factors for Asthma in Children F. Gutin, E. Secord; Allergy/Immunology, Wayne State University/Children’s Hospital of Michigan, Detroit, MI. Multiple Intestinal Atresia and Immunodeficiency H. Rascoff1, E. J. Vukic2, C. Cunningham-Rundles2; 1Pediatrics, Mount Sinai School of Medicine, New York, NY, 2Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY. NK Cell Dysfunction and Hypogammaglobulinemia in a Patient Presenting With Invasive Rhinocerebral Mucormycosis D. R. Doshi1,2, E. Lu1,2, Z. K. Ballas1,2; 1Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 2Iowa City VA Medical Center, Iowa City, IA. Phenotypic Characteristics of Immunocompetent Cells in the Blood of Patients With Pneumonia T. Slavyanskaya1, G. Y. Kosovsky2, R. Sepiashvili1; 1National Institute of Clinical Immunology, Allergology and Asthma, Moscow, RUSSIAN FEDERATION, 2State University, Belgorod, RUSSIAN FEDERATION. Phenotypic Characteristics of Immunocompetent Cells in Blood of Patients With Pneumonia and New Effective Method of Immunotherapy T. Slavyanskaya, G. Kosovsky, Y. Sepiashvili; Inst Cl Immunology & Allergology, Moscow, RUSSIAN FEDERATION. Development of a New 10% Liquid, Triple Virus Reduced Intravenous Immune Globulin Product, New Generation IGIV

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R. Buender1, I. Mittermann2, U. Herz1, R. Valenta2, H. Renz1; 1Department of Clinical Chemistry, University of Marburg, Marburg, GERMANY, 2Department of Pathophysiology, University of Vienna, Vienna, AUSTRIA. Naked DNA Encoding INF-γ Enhances Tubulin Induced Hearing Loss in Guinea Pigs X. Du, H. Matsuno, S. Kanangat, U. Nair, W. Cheng, B. D. Hill, T. J. Yoo; Allergy/Immunology, University of Tennessee, Memphis, TN. The Levels of Bactericidal/Permeability Increasing Protein (BPI) in Body Fluids J. Bartunkova1, A. Sediva2, A. Skalicka2, H. Tomasova3, J. Bartosova4, V. Vavrova4; 1Institute of Immunology, 2nd Medical School, Charles University, Prague, CZECH REPUBLIC, 2Institute of Immunology, Charles University, Prague, CZECH REPUBLIC, 3Institute of Medical Chemistry and Biochemistry, Charles University, Prague, CZECH REPUBLIC, 4Pediatrics, Charles University, Prague, CZECH REPUBLIC. Anti-C1q-autoantibodies in SLE Patients I. A. Perahud1, I. P. Titova1, S. V. Hidchenko1, J. A. Schifferli2, S. Sadallah2, L. P. Titov3, L. M. DuBuske4; 1Belarus State Medical University, Minsk, BELARUS, 2Basel University, Basel, SWITZERLAND, 3Research Institute for Epidemiology and Microbiology, Minsk, BELARUS, 4Immunology Research Institute of New England, Fitchburg, MA. CINCA Syndrome (Chronic Infantile Neurological Cutaneous Articular Syndrome). A Case Report of a Superficial Resemblance to Systemic-Onset JRA With Mutation in CIAS 1 Gene From Thailand K. Kittisarapong1, N. Thavonpanich1, S. Benjapolpitak1, G. Basile2; 1Pediatrics, Ramathibodi Hospital, Bangkok, THAILAND, 2Unite de Recherche sur le Developmental et Pathologique du Systeme Immunitaire, INSERM U 429, Paris, FRANCE.

Poster Session 3405 Sunday, March 21 11:00 AM to 12:00 PM Urticaria and Angioedema: Pathogenesis 426 Hepatitis C & Urticaria: Cause & Effect? N. Siddique, B. N. Pereira, S. H. Arshad; The David Hide Asthma and Allergy Research Centre, St. Mary’s Hospital, Newport, Isle of Wight, UNITED KINGDOM. 427 Monoclonal Gammopathy (MG) in Patients With Angioedema, Urticaria, Respiratory Allergies, and Other Dermatologic Manifestations M. J. Ku1, B. A. Silverman1, P. Kapur2, A. T. Schneider1; 1Allergy and Immunology, Long Island College Hospital, Brooklyn, NY, 2Ochsner Clinic Foundation, New Orleans, LA. 428 Allergic Symptoms Due to Silk Dress T. Valbuena, M. Reche, C. Pascual, M. C. García-Ara, M. MartínEsteban; Allergology, Hospital “La Paz”, Madrid, SPAIN. 429 Urticarial Dermatitis Caused by Dental Implant Adhesive Compounds: A Case Report B. Hadjiev, G. Avshalomov; North Shore-LIJ Healthcare System, New Hyde Park, NY. 430 Contact Urticaria to Compositae: Ratibida columnifera, the Prairie Coneflower C. E. Thornblade, B. A. Whisman, L. L. Hagan; Allergy/Immunology, Wilford Hall Medical Center, Lackland AFB, TX. 431 Is Wide Spectrum Autoantibody Testing Cost-Effective in the Management of Chronic Urticaria (CU)? D. Zauli, G. Vukatana, A. Grassi, G. Ballardini, P. Terlizzi, F. B. Bianchi; Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, Italy, Bologna, ITALY.

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Predictive Value of Autologous Serum Testing (AST) in Patients With Chronic Idiopathic Urticaria (CIU). PK Vedanthan, PA Mahesh, AD Holla. Allergy, Asthma and Chest Center, Mysore, India P. K. Vedanthan; University of Colorado Health Sciences Center, Denver, CO. Chronic Urticaria: What Is Worth Doing in Pediatric Population? S. Pongpreuksa, S. Boochoo, K. Kulthanan, V. Luengvechakarn, N. Visitsunthorn, P. Vichyanond, O. Jirapongsananuruk; Siriraj Hospital, Bangkok, THAILAND. Chronic Urticaria: Incidence of Thyroiditis and Response to Medications A. L. Economides; Institute for Asthma & Allergy, Chevy Chase, MD. Hereditary Angioedema - Retrospective of the Last 20 Years S. Lopes Silva1, A. Spínola Santos1, A. Lopes Pregal1, M. Branco Ferreira1, E. Alonso1, T. Michelena1, E. Pedro1, G. Palma-Carlos1, M. H. Clode2, M. Pereira Barbosa1, A. G. Palma-Carlos2; 1Immunoallergology Unit, Santa Maria Hospital, Lisbon, PORTUGAL, 2Allergy and Clinical Immunology Center, Lisbon, PORTUGAL. Angioedema Without Urticaria in 929 Patients: Description and Proposal for a Diagnostic Approach M. Cicardi, L. Beltrami, L. C. Zingale; Internal Medicine, University of Milan, Milan, ITALY.

Poster Session 3406 Sunday, March 21 11:00 AM to 11:00 AM Urticaria and Angioedema: Therapy 437 Sympathomimetic Amines as a Novel Treatment for Refractory Chronic Idiopathic Urticaria J. H. Check, C. Amadi, H. Kaplan; Dept. OB/GYN, UMDNJ, Robert Wood Johnson Med. School at Camden, Melrose Park, PA. 438 Desloratadine Has a Rapid and Enduring Impact on Signs & Symptoms in Chronic Idiopathic Urticaria J. P. Ortonne1, M. Dron Gonzalvez2, I. Brassac3, M. T. Guinnepain4; 1Hôpital l’Archet 2, Nice, FRANCE, 2Martigues, FRANCE, 3Schering-Plough, Levallois Perret, FRANCE, 4Institut Pasteur, Paris, FRANCE. 439 Steroid Sparing Agents for the Treatment of Patients With Chronic Urticaria Requiring Daily Oral Corticosteroids and Sedating H1 Antihistaminics R. R. Mian, H. Wedner; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO. 440 Intravenous Immune Globulin (IVIG) in a Patient With Urticaria and Hypogammaglobulinemia A. O. Khadavi1, B. Silverman1, C. Cunningham-Rundles2, A. Schneider1; 1Allergy/Immunology, Long Island College Hospital, Brooklyn, NY, 2Mount Sinai Hospital, New York, NY. 441 Mizolastine Provides Effective Symptom Relief in Patients Suffering From Chronic Idiopathic Urticaria: A Randomized, Comparative Study Versus Loratadine in China H. Li, J. Yin, L. Wen, F. Yue, Q. Fang, R. Wang, H. Zhang; Allergy, Peking Union Medical College Hospital, Beijing, CHINA. 442 C1 Inhibitor Concentrate Therapy in 473 Patients With Hereditary and Acquired Angioedema L. C. Zingale, A. Zanichelli, L. Maggioni, M. Cicardi; Internal Medicine, University of Milan, Milan, ITALY.

Poster Session 3407 Sunday, March 21 11:00 AM to 12:00 PM New Trends in Allergy Diagnosis 443 Diagnostic Performance of Various In Vitro Assays for Specific IgE in Adults Allergic to Natural Rubber Latex M. W. Ollert, J. Merkl, J. Ring; Dermatology and Allergy, Technical University Munich, Munich, GERMANY. 444 Endotoxin in Dust Mite Allergen Extracts C. Valerio1, P. Murray2, L. G. Arlian3, J. E. Slater1; 1US Food and Drug Administration, Rockville, MD, 2National Institute of Health, Bethesda, MD, 3Wright State University, Dayton, OH. 445 Chemically Modified Recombinant Fel d 1: A Good Alternative to Hypoallergenic Mutants S. A. Versteeg1, I. Bulder1, A. van Leeuwen1, F. Ferreira2, R. van den Hout3, H. van Schijndel3, R. van Ree1; 1Immunopathology, Sanquin Research, Amsterdam, NETHERLANDS, 2University of Salzburg, Salzburg, AUSTRIA, 3HAL Allergen Laboratories, Haarlem, NETHERLANDS. 446 Successful Standardization of Purified Natural and Recombinant Mite Allergens as Part of the European Union (EU) CREATE Project L. D. Vailes1, A. Tsay1, F. Ferreira2, R. van Ree3, M. D. Chapman1; 1Indoor Biotechnologies, Inc., Charlottesville, VA, 2University of Salzburg, Salzburg, AUSTRIA, 3Central Laboratory of Bloodtransfusion, Amsterdam, NETHERLANDS. 447 Monomorium pharaonis Ant: Identification of New Inhalant Allergens and Characterization of Its Major Allergens C. Kim1, C. Hong2, S. Choi2, H. Park3; 1Department of Internal Medicine, Inha University College of Medicine, Incheon, REPUBLIC OF KOREA, 2Department of Internal Medicine, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA, 3Department of Internal Medicine, Ajou University College of Medicine, Suwon, REPUBLIC OF KOREA. 448 Effects of SDS, PBS, Coca’s and NH4HCO3 Solutions on the Fluorescence Values of Radioallergosorbent Test Inhibition J. L. Sun, H. Y. Zhang, H. J. He, R. Q. Wang; Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, CHINA. 449 Quality Control of Non-Standardized Allergenic Extracts: Major Allergen and IgE Binding of Birch, English Plantain and Olive Pollen G. Plunkett, J. Gaswint, N. Noieam; ALK-Abello, Inc., Round Rock, TX. 450 A Disposable Sampler for Collecting Volumetric Air Samples Onto Agar Media D. Gallup, J. Purves, H. Burge; Environmental Microbiology Laboratory, Inc., San Bruno, CA. 451 Pure Mite Bodies Generate High Quality Allergenic Extracts V. Mahakittikun1, C. Bunnag1, P. Vichyanond1, S. Wongkamchai1, C. Komoltri1, P. Eakpo1, J. J. Boitano2; 1Mahidol University, Bangkok, THAILAND, 2Mahidol University, Stratford, CT. 452 Comparison of Monoclonal Antibodies Produced by In Vitro and In Vivo Methods M. Abebe, V. Kumar, S. Sevinc, H. M. Vijay; Environmental Health, Health Canada, Ottawa, ON, CANADA. 453 Characterization Of 4 Cupressus arizonica Extracts Using Different Solvents J. Carnés1, J. Carnés Isidro2, A. Ferrer3, J. Sastre4, C. Andreu3, E. Fernández-Caldas1; 1C.B.F. LETI S.A., Tres Cantos, SPAIN, 2Hospital Central de la Defensa, Madrid, SPAIN, 3Hospital de la Vega Baja, Alicante, SPAIN, 4Fundación Jiménez Díaz, Madrid, SPAIN. 454 The Detection of an Apicomplexan (Order Neogregarinorida)

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Pathogen in the Dust Mite Acarus siro – A Novel Host-Pathogen Relationship: Implication to Dust Mite Life Cycle and Allergen Extract Purity A. H. B. Loo1, T. C. Ong1, H. Jethanand1, M. S. Choy2, J. R. Barta3, F. T. Chew1; 1Biological Sciences, National University of Singapore, Singapore, SINGAPORE, 2Biochemistry, National University of Singapore, Singapore, SINGAPORE, 3Department of Pathobiology, Ontario Veterinary College, University of Guelph, Canada, ON, CANADA. Relative Utility of Skin Prick Tests, Total IgE and AllergenSpecific IgE in Allergy Diagnosis A. Blaziene, A. Chomiciene, A. Caponiene; Clinic of Pulmonology and Allergology, Vilnius University, Vilnius, LITHUANIA. Characterization of House Dust for Peptidase Activity From Fungal and Mite Allergens Using Monoclonal Antibodies and Specific Peptidase Assays P. J. Meighan, R. Pirzad, J. Baker, A. Cooke; Acaris Ltd, Cambridge, UNITED KINGDOM. Validation of the Purity of Acarid Mite Cultures Used for Allergen Extract Preparation and Identification of Contaminants by Ribosomal DNA Sequencing via a PCR-Cloning- and Sequence Homology-Based Approach L. H. B. Adrian, S. Y. Goh, K. Reginald, Y. F. Gao, H. Jethanand, H. S. Shang, F. T. Chew; Biological Sciences, National University of Singapore, Singapore, SINGAPORE.

Poster Session 3408 Sunday, March 21 11:00 AM to 12:00 PM Modulation of Allergen Specific Immune Responses 458 Quantitative Assessment of the Adherence to Allergoid Sublingual Immunotherapy in Patients With House Dust Mite Sensitization: The INSIT Study C. Lombardi1, F. Gani2, M. Landi3, S. Gargioni1, P. Falagiani4, G. Passalacqua5, G. W. CANONICA5; 1Allergology Unit Dept of Internal Medicine, S.Orsola Hospital, Brescia, ITALY, 2Allergology Unit, L.Gonzaga Hospital, Orbassano, Turin, ITALY, 3ASL, Turin, ITALY, 4Lofarma S.p.A., Milan, ITALY, 5Allergy and Respiratory Diseases, Dept. of Internal Medicine, University of Genoa, Genoa, ITALY. 459 Dominant B Cell Epitope Region of a Vespid Allergen Antigen 5 T. P. King; The Rockefeller University, New York, NY. 460 HLA Class II Transgenic Mice as Models to Study the Allergenicity of Bacterial Protease Y217L BPN’ E. S. Finn1, S. P. Chapoval2, A. Xue3, V. R. Chowdhary3, E. V. Marietta3, T. A. Gaffey3, A. C. Pursifull1, C. S. David3; 1The Procter & Gamble Co., Cincinnati, OH, 2Yale University, New Haven, CT, 3Mayo Clinic, Rochester, MN. 461 The Influence of Oral Tolerance on Local and Systemic Immunoregulation in a Murine Model of Type I Allergy G. N. Drannik1, A. Nakonechna1, H. Renz2, M. Wegmann2, L. M. DuBuske3; 1National Medical University, Kiev, UKRAINE, 2Philipps University Marburg, Marburg, GERMANY, 3Immunology Research Institute of New England, Fitchburg, MA. 462 DNA Vaccination Inhibits Th2 Responses and Airway Inflammation in Mice Sensitized With Phl p 5b Y. Darcan1, A. Petersen1, J. Galle2, W. Becker1, J. Ahmed3, U. Seitzer3; 1Biochemical and Molecular Allergology, Research Center Borstel, Borstel, GERMANY, 2Clinical and Experimental Pathology, Research Center Borstel, Borstel, GERMANY, 3Veterinary Infectiology and Immunology, Research Center Borstel, Borstel, GERMANY. 463 Loss of Antigen-Specific IgE to Aeroallergens in Children Between Ages Two and Four Years

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M. R. Simon1, S. Havstad2, C. C. Johnson2, E. L. Peterson2, D. R. Ownby3; 1Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Henry Ford Health System, Detroit, MI, 2Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI, 3Section of Allergy and Immunology, Department of Pediatrics, Medical College of Georgia, Augusta, GA. Contrasting IgE and IgG Responses to Dust Mite, Cat, and Dog Allergens Among Children in New Zealand Who Have High Exposure to Each Allergen E. A. Erwin1, K. Wickens2, N. J. Custis1, M. S. Perzanowski3, D. Barry4, J. Crane2, T. A. E. Platts-Mills1; 1Allergy and Immunology, University of Virginia, Charlottesville, VA, 2Wellington School of Medicine and Health Sciences, Wellington, NEW ZEALAND, 3Columbia, New York, NY, 4Healthcare Hawkes Bay, Hastings, NEW ZEALAND. Specific IgE Response in Children With Cat Contact Is Different Between Social Groups U. Krämer1, C. Apfelbacher2, J. Ring3, H. Behrendt2; 1Epidemiology, Institut für Umweltmedizinische Forschung, Düsseldorf, GERMANY, 2Klinische Kooperationsgruppe Umweltdermatologie TUM/GSF, München, GERMANY, 3Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, München, GERMANY. The Effects of Dog Ownership on IgE and IgG Antibodies Among School Age Children in Sweden P. Pipkorn1, N. J. Custis2, E. Ronmark3, M. S. Perzanowski4, E. A. Erwin5, B. Lundback6; 1University of Gothenburg, Gothenburg, SWEDEN, 2University of Virginia, Charlottesville, VA, 3University of Umea, Umea, SWEDEN, 4Columbia, New York, NY, 5Allergy and Immunology, University of Virginia, Charlottesville, VA, 6Karolinska Institute, Stockholm, SWEDEN. Cockroach and Dust Mite Allergens Have Potent Toll-like Receptor 4 Dependent Innate Immune-Stimulatory Activity B. J. Song1, A. M. Schiltz1, L. Remigio2, D. Riches2, A. H. Liu1; 1Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, CO, 2Program of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO. Identification of T Cell Epitopes Derived From Cockroach Allergens A. Reefer1, A. Pomes2, M. Chapman2, N. Custis1, J. Hammer3, J. Woodfolk1; 1Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA, 2Indoor Biotechnologies, Inc., Charlottesville, VA, 3Department of Genomics and Information Sciences, Hoffman-La Roche Inc., Nutley, NJ. Comparable T-Cell Activation Induced by Natural and Recombinant Allergens P. Adler Würtzen, J. Holm, T. Lenhard, P. Thorsted, H. H. Jacobi, A. Millner; Research Department, ALK-Abelló, Hørsholm, DENMARK. Different Isotype Pattern of Antibody Response Between Food Allergen and Inhalant Allergen in Atopic Dermatitis G. Noh1, N. Cho2, J. Oh3, C. Hong4; 1Allergy & Clinical Immunology, Seoul Allergy Clinic, Seoul, REPUBLIC OF KOREA, 2Microarray & Molecular Immunology, Seoul Allergy Research Institute, Food BioTech Co.Ltd, Seoul, REPUBLIC OF KOREA, 3Pediatrics, Hanyang University, College of Medicine, Kuri, REPUBLIC OF KOREA, 4Internal Medicine, Yonsei University, College of Medicine, Seoul, REPUBLIC OF KOREA. Prevalence of Atopy and Parasitic Infections in Urban and Rural Children in Ghana B. B. Obeng1,2, A. S. Amoah1, R. Van Ree3, I. Hesse4, K. Bosompem1, L. Rodrigues5, S. Chai2, M. D. Wilson1, M. Yazdanbakhsh2, D. A. Boakye1; 1Parasitology, Noguchi Memorial Institute for Medical Research, Accra, GHANA, 2Parasitology, Leiden University Medical Centre, Leiden, NETHERLANDS, 3Allergy, Sanquin

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CLB, Amsterdam, NETHERLANDS, 4Medicine, Korle- Bu Teaching Hospital, Accra, GHANA, 5Epidemiology, London School of Hygiene and Tropical Medicine, London, UNITED KINGDOM. Depletion of Specific Cockroach Allergens May Not Affect Overall Allergenicity Determinations A. A. Gam, J. E. Slater; Laboratory of Immunobiochemistry, FDA/CBER, Rockville, MD. Specific IgE to Indoor Molds in Patients With Respiratory Allergies D. Galante1, P. A. Tassinari1, A. Conesa1, E. Trejo2, N. E. Bianco1; 1Institute of Immunology, Universidad Central de Venezuela, Caracas, VENEZUELA, 2Institute of Experimental Medicine, Universidad Central de Venezuela, Caracas, VENEZUELA. Mapping of Der p 2 Antibody Binding Epitopes by Site Directed Mutagenesis H. Ipsen1, H. Henmar1, C. Bolwig1, O. Duffort2, D. Barber2, F. Polo2, J. Larsen1; 1ALK-Abello, Hørsholm, DENMARK, 2ALKAbello, Madrid, SPAIN. Antigen-Specific Cytokine Responses After Intranasal Coexposure to Particles and Antigen C. de Haar, I. van Arkel, R. Bleumink, R. Pieters; Immunotoxicology, IRAS Utrecht University, Utrecht, NETHERLANDS. Immunological Characteristics of Heterodimeric Recombinant Fel d 1 U. Seppälä, P. A. Wurtzen, H. Ipsen, H. Jacobi, M. Spangfort; Biochemical and Biological Allergy Research, ALK-Abello’, Horsholm, DENMARK.

Poster Session 3409 Sunday, March 21 11:00 AM to 12:00 PM Food Hypersensitivity I 477 The Clinical Investigation of Kiwi Fruit Allergy J. S. A. Lucas, K. Collins, K. Grimshaw, J. Warner, J. Hourihane; Allergy and Inflammation Sciences, University of Southampton, Southampton, UNITED KINGDOM. 478 The Effect of Delayed Introduction of Solids on Rates of Eczema and Infant Sensitization to Food and Aeroallergens at 1 and 3 Years of Age K. E. C. Grimshaw, G. H. S. Vance, R. A. Briggs, N. D. Diaper, J. A. Warner, J. O. Warner; Child Health, University of Southampton, UK, Southampton, UNITED KINGDOM. 479 The Risk of Food Challenges M. K. Conover-Walker, R. A. Wood; Pediatrics, Johns Hopkins Hospital, Baltimore, MD. 480 Relationship Between Platanus acerifolia Pollinosis and Food Allergy in Barcelona Area R. Tella, M. Dall’Aglio, M. San Miguel-Moncin, R. Alonso, J. Bartra, B. Fernandez-Parra, A. Cistero-Bahima; Allergy Department, Institut Universitari Dexeus, UAB, Barcelona, Barcelona, SPAIN. 481 Specific IgE Level and Prediction of Tolerance in Mustard Allergy F. Rancé1, P. Micheau1, D. Janka1, M. Abbal2, L. Söderström3; 1Hôpital des Enfants, Toulouse, FRANCE, 2Laboratoire d’Immunologie, Toulouse, FRANCE, 3Pharmacia Diagnostic, Uppsala, SWEDEN. 482 Peanut Allergy: Recurrence and Its Management D. M. Fleischer, M. K. Conover-Walker, R. A. Wood; Pediatric Allergy and Immunology, Johns Hopkins, Baltimore, MD. 483 Birch and Ragweed Pollen Immunotherapy in the Treatment of Pollen-Food Allergy Syndrome A. H. Nowak-Wegrzyn1, S. Mofidi1, S. Ma2, L. Bardina1, K. Beyer1; 1Pediatrics, Mount Sinai School of Medicine, New York,

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NY, 2Clinical Immunology, Mount Sinai School of Medicine, New York, NY. Fruit and Vegetable Allergy in Children S. Ma, A. Nowak-Wegrzyn; Mount Sinai School of Medicine, New York, NY. IgE-Binding Peptides Coupled to a Commercial System as Diagnostic Instrument for Persistent Cow’s Milk Allergy K. Beyer1, K. M. Jarvinen2, L. Bardina2, M. Mishoe2, K. Turjanmaa3, B. Niggemann1, H. A. Sampson2; 1Pediatrics, Charite, Berlin, GERMANY, 2Pediatrics, Mount Sinai School of Medicine, New York, NY, 3Pediatrics, Tampere University Hospital, Tampere, FINLAND. Treatment of Eosinophilic Esophagitis With Specific Food Elimination Diet Directed by a Combination of Prick Skin Test and Patch Tests T. Andrews1, J. M. Spergel1, C. A. Liacouras2; 1Allergy Wood Center, The Children’s Hospital of Philadelphia, Philadelphia, PA, 2Gastroenterology Wood Center, The Children’s Hospital of Philadelphia, Philadelphia, PA. Esophageal Inflammation in Infants With Gastroesophageal Reflux Symptoms and Persistent Distress R. G. Heine1,2, S. Ymer3, C. W. Chow4, D. J. S. Cameron2, G. P. Davidson5, D. J. Moore5, M. L. Tang3, D. J. Hill1; 1Allergy Department, Royal Children’s Hospital, Melbourne, AUSTRALIA, 2Gastroenterology Department, Royal Children’s Hospital, Melbourne, AUSTRALIA, 3Immunology Department, Royal Children’s Hospital, Melbourne, AUSTRALIA, 4Department of Anatomical Pathology, Royal Children’s Hospital, Melbourne, AUSTRALIA, 5Gastroenterology Department, Women’s and Children’s Hospital, Adelaide, AUSTRALIA. Presence of Allergenic Food in the Diet of Children Given a Prophylactic Allergen-Restricted Diet B. J. Vlieg-Boerstra1, B. J. Beusekamp2, C. M. A. Bijleveld3, S. van der Heide1, S. A. A. Wolt-Plompen3, J. Kukler1, E. J. Duiverman3, A. E. J. Dubois1; 1Allergy, University Hospital Groningen, Groningen, NETHERLANDS, 2Dietetics, University Hospital Groningen, Groningen, NETHERLANDS, 3Beatrix Children’s Hospital, University Hospital Groningen, Groningen, NETHERLANDS. Sensitization Rates to Food Allergens and Prevalence of Reported and Objectively Assessed Food Allergies Amongst 15Year Olds in UK B. Pereira1, C. Venter1, M. Fenn1, S. Matthews1, J. Grundy1, B. Mealy1, N. Siddique1, S. H. Arshad1,2, T. Dean1,3; 1St. Mary’s Hospital, The David Hide Asthma & Allergy Research Centre, Newport, Isle of Wight, UNITED KINGDOM, 2University of Southampton, Southampton, UNITED KINGDOM, 3University of Portsmouth, Portsmouth, UNITED KINGDOM. Comparison of IgE Reactivity of Recombinant and Natural Pen a 1 by RAST and Mediator Release J. F. Villacis1, N. Lehrer1, L. Vogel2, S. Schicktanz2, S. Randow2, G. Reese2, J. M. El-Dahr1, S. Vieths2, S. B. Lehrer1; 1Section of Clinical Immunology, Allergy, and Rheumatology, Tulane University Medical Center, New Orleans, LA, 2Department of Allergology, Paul-Ehrlich-Institut, Langen, GERMANY. Nationwide Survey of Immediate Type Food Allergy in Japan T. Imai1, M. Ebisawa2; 1Pediatrics, Showa University School of Medicine, Tokyo, JAPAN, 2Pediatric Allergy, National Sagamihara Hospital, Kanagawa, JAPAN. Reactions to Food in Children Recurs After Negative Oral Challenge P. G. L. Lidman, W. T. A. Watson, F. E. R. Simons, A. B. Becker; Pediatric Allergy and Clinical Immunology, University of Manitoba, Winnipeg, MB, CANADA. Prediction of the Development of Tolerance to Milk in Children With Cow’s Milk Hypersensitivity T. T. Vanto1, K. Juntunen-Backman2, K. Kalimo3, T. Klemola2, P.

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Koskinen4; 1Department of Pediatrics, Turku University Hospital, Turku, FINLAND, 2Department of Allergology, Skin and Allergy Hospital, Helsinki, FINLAND, 3Department of Dermatology, Turku University Hospital, Turku, FINLAND, 4Central Laboratory, Turku University Hospital, Turku, FINLAND. Chestnut Allergy: Beyond the Latex-Fruit Syndrome P. Rico, J. F. Crespo, A. Feliu, J. Rodriguez; Allergy, Hospital 12 Octubre, Madrid, SPAIN. The Effect of Living in a Peanut Free Home on the Risk of Accidental Peanut Ingestion H. Seavolt1, N. Orfan1, T. Wilson2; 1Allergy and Asthma Center, Hagerstown, MD, 2Trajectory Inc., Cincinatti, OH. Sensitization Rates to Food and Aeroallergens Amongst 1 Year olds in UK – A Population Based Study J. Grundy1, B. Pereira1, B. Mealy1, M. Fenn1, N. Siddique1, C. Venter1, S. Matthews1, S. H. Arshad1,2, T. Dean1,3; 1St. Mary’s Hospital, The David Hide Asthma and Allergy Research Centre, Newport, Isle of Wight, UNITED KINGDOM, 2University of Southampton, Southampton, UNITED KINGDOM, 3University of Portsmouth, Portsmouth, UNITED KINGDOM. Parental Coping With Childhood Food Allergies K. D. Stone, F. J. Twarog, S. Raiselis, E. Bailey, L. C. Schneider; Division of Immunology, Children’s Hospital, Boston, MA. Treatment of Egg Allergy in Children Through Oral Desensitization A. D. Buchanan1, L. Christie2,3, K. M. Althage2,3, S. M. Jones2,3, L. A. Pons1, R. M. Helm4, A. W. Burks1; 1Pediatrics, Duke University Medical Center, Durham, NC, 2Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 3Arkansas Children’s Hospital, Little Rock, AR, 4Microbiology, University of Arkansas for Medical Sciences, Little Rock, AR. Characteristics of Infants Born From Atopic vs. Non-atopic Mothers During the First 6 Months of the Infants Life C. Venter, B. Pereira, C. Gant, M. Fenn, J. Grundy, B. Mealy, S. H. Arshad, T. Dean; The David Hide Asthma and Allergy Research Centre, Newport, UNITED KINGDOM. Public Perception of Food Allergy in a Colombian Population V. T. Villalba, L. C. Hernandez, J. A. Marrugo, L. R. Caraballo; Immunology, Universidad de Cartagena, Cartagena, COLOMBIA. Wheat Allergy: A Prospective Study in Children and Adults, With Reference to Celiac Disease A. A. D. Moneret-Vautrin1, A. D. Moneret-Vautrin2; 1Dept of Internal Medicine, Clinical Immunology and Allergology, University Hospital, Nancy, FRANCE, 2Dept of Internal Medicine, Clinical Immunology and Allergology, University Hospital, Nancy, FRANCE.

Poster Session 3410 Sunday, March 21 11:00 AM to 12:00 PM Food Hypersensitivity II 502 Peanut Resensitization After Negative Skin Tests and Negative Oral Challenge P. E. Kerr, A. Ham Pong; Children’s Hospital of Eastern Ontario, Ottawa, ON, CANADA. 503 Melon (Cucumis melo) Induced Allergic Sensitization in Occupationally Exposed Individuals C. Andreu1, A. Ferrer1, J. Huertas2, J. Carnes3, E. Fernández-Caldas3; 1Allergology, Hospital de la Vega Baja, Alicante, SPAIN, 2Allergology, Hospital Naval del Mediterraneo, Cartagena, SPAIN, 3Research & Development, C.B.F. LETI, S.A., Tres Cantos, SPAIN. 504 Detection of Genetically Modified Soybean by Monoclonal and Polyclonal Antibodies

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H. Park; Pediatrics, Samsung Medical Center, Seoul, REPUBLIC OF KOREA. Allergenicity of Peanut Protein Isolate After In Vitro Gastric and Pancreatic Hydrolysis Assessed in the Presence of Plant Polysaccharides J. Mouécoucou1, S. Frémont2, C. Sanchez3, C. Villaume4, D. Moneret-Vautrin1, L. Méjean1; 1Laboratoire des Sciences animales ENSAIA-INPL, Vandoeuvre-les-Nancy, FRANCE, 2Faculté de Médecine, Laboratoire de Biochimie Médicale et Pédiatrique, Vandoeuvre-les-Nancy, FRANCE, 3Ensaia-inpl, Laboratoire de Physico-Chimie et Génie Alimentaires, Vandoeuvre-les-Nancy, FRANCE, 4Faculté de Médecine, EMI 0014 INSERM, Laboratoire de Pathologie Cellulaire et Moléculaire en Nutrition, Vandoeuvreles-Nancy, FRANCE. Immunochemical Study of a Pineapple (Ananas comosus) Extract J. A. Marrugo, D. Mercado, L. D. Hernandez, N. Perez, L. R. Caraballo; Immunology, Universidad de Cartagena, Cartagena, COLOMBIA. Sequencing of Soy Oil and Soy Lecithin Allergens Y. Errahali1, G. Kanny1, M. Morisset1, C. Cren-Olive2, C. Rolando2, M. Metche1, D. A. Moneret-Vautrin1, J. P. Nicolas1, S. Fremont1; 1Faculty of Medicine, University Nancy I, Vandoeuvre les Nancy, FRANCE, 2Laboratoire de Chimie organique et Macromoleculaire, Université des Science et Technologies de Lille, Lille, FRANCE. Post-Transplant Food Allergy Development and Chronic Diarrhea in Pediatric Patient Taking Tacrolimus as Major Immunosuppressant A. A. Arrey-Mensah, A. A. Arrey-Mensah, R. U. Sorensen; Pediatrics, LSUHSC, New Orleans, LA. An Alternative Food Challenge in Oral Allergy Syndrome R. Alonso, E. Enrique, M. San Miguel-Moncin, R. Tella, B. Fernandez-Parra, J. Bartra, A. Cistero-Bahima; Allergy Department, Institut Universitari Dexeus, UAB, Barcelona, Barcelona, SPAIN. Parental Adherence to Peanut-free Lunch Guidelines in Schools in Montreal, Canada D. K. Banerjee1, R. S. Kagan1, E. Turnbull2, L. Joseph3, Y. St. Pierre2, C. Dufresne4, K. Gray-Donald5, A. E. Clarke6; 1Clinical Immunology/Allergy, McGill University Health Centre, Montreal, PQ, CANADA, 2Clinical Epidemiology, McGill University Health Centre, Montreal, PQ, CANADA, 3Epidemiology and Biostatistics, McGill University, Montreal, PQ, CANADA, 4Association Quebecoise des Allergies Alimentaires, Montreal, PQ, CANADA, 5School of Dietetics and Human Nutrition, McGill University, Montreal, PQ, CANADA, 6Clinical Immunology/Allergy and Clinical Epidemiology, McGill University Health Centre, Montreal, PQ, CANADA. Pru av 2, the Major Allergen From Sweet Cherry, Possesses Cross-reactive Carbohydrate IgE-Epitopes H. C. Fuchs1, C. Radauer1, A. Mari2, F. Altmann3, M. Bublin1, O. Scheiner1, H. Breiteneder1; 1Department of Pathophysiology, University of Vienna, AKH, EBO 3Q, Vienna, AUSTRIA, 2Allergy Data Laboratories p.s.c., Latina, ITALY, 3University of Natural Resources and Applied Life Sciences, Vienna, AUSTRIA. PR-1, a Novel Class of Plant Phatogenesis-Related Proteins Involved in Food Allergy T. Asensio Sánchez; Allergy, Hospital Universitario Río Hortega, Valladolid, SPAIN. Three Step Fermented Soybean Paste and Its Allergenicity D. Son1, C. Ryu2, K. Ahn1, S. Lee1; 1Sungkyunkwan University, Seoul, REPUBLIC OF KOREA, 2Gyeongsang National University, Jinju, REPUBLIC OF KOREA. Gold Kiwi Fruit - A New Food Allergen S. A. Lewis, J. O. Warner, J. O. Hourihane, J. S. A. Lucas; University of Southampton, Southampton, UNITED KINGDOM.

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Roasting May Alter the IgE Binding Epitopes and Sensitizing Ability of Peanut Allergens S. J. Maleki1, K. Yamaki2, C. Lewenson3, M. Galeano1, E. T. Champagne4, K. Shinohara5; 1Food Allergy, USDA, New Orleans, LA, 2Division of Crop Function Development, National Agricultural Research Organization, Fukushima, JAPAN, 3Food Allergy, Miami Dade Community College, Miami, FL, 4Food Processing and Sensory Quality, USDA, New Orleans, LA, 5National Food Research Institute, AFFRC, Tsukuba, JAPAN. Identification and Standardization of Anti Food Allergy Chinese Herbal Formula FAHF-5 by HPLC Chromatographic Fingerprint Z. M. Zou1, H. W. Zhang2, K. D. Srivastava1, H. A. Sampson1, X. M. Li1; 1Pediatrics, Mount Sinai School of Medicine, NY, NY, 2Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, CHINA. Food Fears in Children With Food Allergies L. Christie1, J. E. Watson2, S. M. Jones2; 1Pediatrics, Arkansas Children’s Hospital, Little Rock, AR, 2Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR. Use of an Amino Acid-Based Formula in the Management of Cow’s Milk Allergy and Multiple Food Protein Intolerance in Children E. Isolauri1, H. A. Sampson2; 1Department of Paediatrics, University of Turku, Turku, FINLAND, 2Department of Pediatrics, Mount Sinai School of Medicine, New York, NY. Factors Associated With Avoidance of Peanuts and/or Other Nuts During Pregnancy and Lactation T. Dean1,2, C. Venter1,3, B. Pereira1, C. Gant1, M. Fenn1, J. Grundy1, B. Mealy1, S. H. Arshad1,3; 1St. Mary’s Hospital, The David Hide Asthma and Allergy Research Centre, Newport, Isle of Wight, UNITED KINGDOM, 2University of Portsmouth, Portsmouth, UNITED KINGDOM, 3University of Southampton, Southampton, UNITED KINGDOM. Comparing the Effects of Boiling, Frying and Roasting on the Allergenicity of Peanuts D. A. Schmitt, S. J. Maleki; SRRC-ARS-USDA, New Orleans, LA. Microarray Assessment of IgE-Binding Proteins in Lentils (Lens culinaris L.) M. G. Zeece1, G. Sarath2, J. Markwell3, N. Palmer1, J. Steckelberg1, J. Schultz4, C. Pascual5; 1Food Science, University of Nebraska, Lincoln, NE, 2USDA-ARS, Lincoln, NE, 3Biochemistry, University of Nebraska, Lincoln, NE, 4University of Nebraska, Lincoln, NE, 5Hospital Universitario, “La Paz”, Madrid, SPAIN. Frequent Occurrence of IgE to Seeds of Rape, Oilseed Rape, Mustard and Soy in Children Suspected for Food Allergies T. Puumalainen1, S. Poikonen2, K. Vaali1, T. Reunala2, K. Turjanmaa2, T. Palosuo1; 1National Public Health Institute, Helsinki, FINLAND, 2Department of Dermatology, Tampere University Hospital, Tampere, FINLAND. Immunologic Food Protein Intolerance, Pseudopolypoid Lymphonodular Hyperplasia and Hypogammaglobulinemia Responsive to Steroids S. L. Friedlander1, B. B. Dahms2, S. Blanchard3, M. Berger4; 1Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, OH, 2Pathology and Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, OH, 3Pediatric Gastroenterology and Nutrition, Rainbow Babies and Childrens Hospital, Cleveland, OH, 4Pediatrics and Pathology, Rainbow Babies and Childrens Hospital, Cleveland, OH. Cross-Reactivity of Walnut, Cashew, and Hazelnut Legumin Proteins in Tree Nut Allergic Patients M. L. Wallowitz1, S. Teuber1, K. Beyer2, H. A. Sampson3, K. H. Roux4, S. K. Sathe4, F. Wang4, J. Robotham4; 1UCDavis, Davis,

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Poster Session 3411 Sunday, March 21 11:00 AM to 12:00 PM Patient Perceptions, Learning and Adherence 527 Breathing Counts: A Community-Focused Empowerment Model of Asthma Health Education L. Dill1, B. McGee2, R. Pitcher1; 1Asthma, Health and Environmental Resource Center, San Francisco, CA, 2Health and Environmental Resource Center, San Francisco, CA. 528 Adherence With Oral Montelukast Sodium or Fluticasone Propionate in a Clinical Trial C. S. Rand, A. Bilderback, J. Krishnan, K. Riekert, K. Schiller, for the MIAMI Study Research Group; Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD. 529 Parents’ Perception and Knowledge About Corticosteroid S. Huang; Department of Pediatrics, Univ. of FL College Medicine, Gainesville, FL. 530 Surveillance for Atopic Sensitization in Infants and Young Children by Skin Prick Test W. Rangchaikul, P. Suntipraron, T. Wirawarn, T. Choketeeraswad, B. Boonpirak, P. Chatchatee, J. Ngamphaiboon; Division of Allergy and Immunology, Department of Pediatrics, King Chulalongkorn Memorial Hospital, Bangkok, THAILAND. 531 Factors That Predict Which Parents Will Address Environmental Asthma Triggers M. Cabana, K. Slish, R. Brown, T. Lewis, B. Nan, X. Lin, N. Clark; University of Michigan School of Medicine & School of Public Health, Ann Arbor, MI. 532 Medication Event Monitoring System (MEMS®): The Asthma Clinical Research Network (ACRN) Experience N. J. Rollings1, R. R. Zimmerman1, T. S. King1, C. A. Sorkness2; 1Health Evaluation Sciences, Pennsylvania State University, Hershey, PA, 2Pharmacology, University of Wisconsin, Madison, WI. 533 Asthma Care in the Internal Medicine (IM) Clinic of a Community Hospital K. Alvi1, C. Lauter2; 1Department of Medicine, William Beaumont Hospital, Royal Oak, MI, 2Division of Allergy-Immunology, William Beaumont Hospital, Royal Oak, MI. 534 Greater Adherence in Montelukast Patients Compared to Those on Fluticasone F. C. Allen-Ramey1, D. T. Anstatt1, A. A. Riedel2, L. E. Markson1; 1Outcomes Research & Mgmt., Merck & Co., Inc., West Point, PA, 2Economic & Outcomes Research Division, Ingenix, Inc., Eden Prairie, MN. 535 [Withdrawn] 536 Learning Preferences of Caretakers of Asthmatic Children M. D. Silva1, C. Dinakar2; 1Univ of Missouri at Kansas City, Kansas City, MO, 2Pediatrics, Section of Allergy/Asthma/Immunology, Univ of Missouri at Kansas City, Kansas City, MO. 537 Parent-Youth Teamwork in Pediatric Asthma Management

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C. D. Adams1, K. E. Joseph2, J. E. MacLaren2, M. DeMore2, L. Koven2, M. F. Detweiler2, C. Muller2, N. W. Wilson3, M. B. Hogan3; 1Children’s Mercy Hospital, University of MissouriKansas City, Kansas City, MO, 2Department of Psychology, West Virginia University, Morgantown, WV, 3Department of Pediatrics, West Virginia University, Morgantown, WV. Determining the Definition of Non-Adherence With Fluticasone Pressure-MDI for Entry Into an Intervention Protocol to Improve the Adherence of Adolescent Asthmatics R. Wachs, A. Weinstein, A. Lateef, E. Yosef, S. McGeady; Pediatrics, Alfred I Dupont Hospital for Children, Wilmington, DE.

Poster Session 3412 Sunday, March 21 11:00 AM to 12:00 PM Regulation of Allergy & Inflammation 539 The Effect of Der f-Induced Airway Inflammation on Airway Remodeling in a Murine Model of Allergic Asthma S. S. Kwon1, S. J. Kim2, S. Y. Lee2, Y. K. Kim2, K. H. Kim2, H. S. Moon2, J. S. Song2, S. H. Park2; 1Dept. of Internal Medicine, Holy Family Hospital, Catholic University of Korea, Medical College, Bucheon City, Kunggido, REPUBLIC OF KOREA, 2Dept. of Internal Medicine, Catholic University of Korea, Medical College, Seoul, REPUBLIC OF KOREA. 540 Intranasal Vaccination With Peptidoglycan Primes Mice for Th2 Biased Airway Hypersensitivity Responses, While Intranasal Vaccination With Immunostimulatory Sequence Oligodeoxynucleotide Is Protective A. A. Horner1, L. Dang2, L. Libet2, D. Chisholm2; 1Medicine, University of CA-San Diego School of Medicine, La Jolla, CA, 2Department of Medicine, UCSD School of Medicine, La Jolla, CA. 541 Comparison of ECP, RANTES and Eotaxin in Nasopharyngeal Secretion in Bronchiolitis H. Kim; Dept. of Pediatrics, Catholic University of Korea, Holy Family Hospital, Pucheon, REPUBLIC OF KOREA. 542 Adjuvant Activity of Intact Pollen Z. Allakhverdi, G. Delespesse; Notre-Dame Hospital, CHUM Research Center, Montreal, PQ, CANADA. 543 Upregulation of Eosinophil Adhesion to Conjunctival Epithelial Cells by Allergic Tears Is Inhibited by Treatment With Olopatadine J. L. Stahl1, E. B. Cook1, A. M. Brooks1, F. M. Graziano1, N. P. Barney2; 1Medicine, University of Wisconsin-Madison, Madison, WI, 2Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI. 544 Platelet Abnormalities in Asthma and Allergy M. Ellaurie1, G. Wang2; 1Department of Medicine, Pennsylvania State University, Hershey Medical Center, Hershey, PA, 2Department of Cellular and Molecular Physiology, Penn State University, Hershey Medical Center, Hershey, PA. 545 Selenium Status Is Decreased in Patients With Allergic Diseases: A New Focus on an Old Trace Element as a Possible Modifier of Th1/Th2 Dichotomy R. Farid1, R. Pishnamaz1, A. Ranjbar2, Z. Nikjoo1, A. Pizzulli2; 1Mashad University of Medical Sciences, Mashad, IRAN (ISLAMIC REPUBLIC OF), 2The pediatric practice for Clinical Immunology and Allergy, Cologne, GERMANY. 546 Desloratadine Treatment Reduces Systemic Allergic Inflammation Following Nasal Allergen Provocation in Patients With Allergic Rhinitis and Asthma S. M. Reinartz1, S. E. Overbeek2, C. M. van Drunen1, G. J. Braunstahl2, H. C. Hoogsteden2, W. J. Fokkens1; 1Otorhinolaryngology, AMC, Amsterdam, NETHERLANDS, 2Pulmonary Medicine, Erasmus MC, Rotterdam, NETHERLANDS.

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CA, 2Clinic of Pediatrics, Charite CVK, Berlin, GERMANY, 3Mount Sinai School of Medicine, New York, NY, 4Florida State University, Tallahassee, FL. Th1/Th2 T Cell Sensitivity to Rice in an Infant H. C. Gray1, B. A. Becker2, A. P. Knutsen2; 1Allergy and Immunology, Saint Louis University School of Medicine, St. Louis, MO, 2Pediatric Allergy and Immunology, Saint Louis University School of Medicine, St. Louis, MO. Individuals With Cow’s Milk Allergy Are Sensitized to Milk From Deer and Ibex But Not to Milk From Pork. Is There a “Kosher” Epitope? Y. Katz, G. Zadik-Mnuchin; Allergy & Immunology Inst., AssafHarofeh medical center, Zeriffin, ISRAEL.

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Efficacy Of Montelukast in Recurrent Wheezing Infants and Small Children M. V. Nanulescu, M. Farcau, L. Popescu, M. Muresan, G. E. Ichim; Clinica Pediatrie 3, University of Medicine, Cluj-Napoca, ROMANIA. Involvement of Drug-Specific T Cells in Drug-Induced Interstitial Nephritis M. Keller1, M. Britschgi1, T. Fehr2, M. G. Mohaupt3, J. Neuweiler4, W. J. Pichler1; 1Institute of Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern, SWITZERLAND, 2Division of Nephrology, Kantonsspital, St-Gall, SWITZERLAND, 3Institute of Nephrology/Hypertension, Inselspital, Bern, SWITZERLAND, 4Institute of Pathology, Kantonsspital, St-Gall, SWITZERLAND. Allergen Specific IgG Memory B Cells in Atopic and NonAtopic Individuals E. Luger1, G. Achatz2, H. Olze3, C. Mecho4, A. Radbruch1, C. Berek1; 1German Rheumatism Research Center, Berlin, GERMANY, 2Department of Genetics, University of Salzburg, Department of Genetics, AUSTRIA, 3Charite’, HNO, Virchow Klinikum, Berlin, GERMANY, 4HNO, St. Johann Hospital, Salzburg, AUSTRIA. Relationship of Maternal Skin Test Responses to Infant CordBlood Progenitor Cytokine Receptor Expression M. M. Cyr1, H. Hatfield1, J. A. Dunstan2, S. L. Prescott2, P. G. Holt3, J. A. Denburg1; 1Medicine, McMaster University, Hamilton, ON, CANADA, 2University of Western Australia, Perth, AUSTRALIA, 3Telethon Institute for Child Health Research, Perth, AUSTRALIA. The Benefit of Using Ceterizine (Zyrtec) With Stimulant in Children With Comorbid Allergy and ADHD I. Melamed1, B. G. Bender2, M. Z. Wamboldt3; 1National Jewish Center, 1st Allergy and Clinical Research, Englewood, CO, 2National Jewish Center, National Jewish Center, Denver, CO, 3Psychiatry, University of Colorado, The Childrens Hospital, Denver, CO. Allergen Inhalation Increases mRNA Expression in Induced Sputum From Mild Atopic Asthmatics E. M. Hessel; Dynavax Technologies, Berkeley, CA. The Effect of Salmeterol (SAL) on the Late Phase Response (LPR) to Antigen Challenge (AC), Sputum Eosinophilia and Generation of IL-5 and IFN-gamma C. Swenson, J. Laseman, G. Crisafi, W. Busse; University of Wisconsin, Madison, WI. Increased Allergic Airway Responses in a Murine Model of Intestinal Anaphylaxis E. B. Brandt, T. A. Scribner, L. M. Hassman, M. E. Rothenberg; Dept of Pediatrics; Div of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. Stimulation of Innate Immune Response Induces Long Term Allergic Sensitization and Allergic Airway Inflammation Independent of STAT-6 B. K. Choudhury1, J. S. Wild1, N. Dharajiya1, A. Bacsi2, R. Alam3, I. Boldogh2, S. Sur1; 1NIH Asthma and Allergic Diseases Research Center and the Departments of Internal Medicine, University of Texas Medical Branch, Galveston, TX, 2Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 3Division of Allergy and Immunology, Department of Medicine, National Jewish Medical and Research Center, Denver, CO. Systemic PGE2 Neutralization Results in Enhanced Allergic Pulmonary Inflammation in a Murine Model R. Peebles, Jr.1, S. J. Mnich2, K. Goleniewska1, J. F. O’Neal1, D. Mitchell1, B. S. Graham3, J. R. Sheller1; 1Division of Allergy, Pulmonary, & Critical Care Medicine, Vanderbilt Univ School of Medicine, Nashville, TN, 2Pharmacia, St. Louis, MO, 3VRC/NIAID, Bethesda, MD.

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Reactive Oxygen Species Generated by Pollen Grain’s NAD(P)H Oxidase Augment Allergic Ocular Symptoms A. Bacsi1, N. Dharajiya2, B. K. Choudhury2, S. Sur2, I. Boldogh1; 1Department of Microbiology and Immunology, UTMB, Galveston, TX, 2NIH Asthma and Allergic Diseases Research Center of Department of Internal Medicine, UTMB, Galveston, TX. Evidence for a Th2-to-Th1 Shift in IL-4 Deficient Mice in Response to Chronic House Dust Mite Exposure J. R. Johnson1, F. K. Swirski1, R. Fattouh1, M. D. Inman2, M. Jordana1; 1Pathology and Molecular Medicine, McMaster University, Hamilton, ON, CANADA, 2Firestone Institute for Respiratory Health, McMaster University, Hamilton, ON, CANADA. Oxidative Stress Generated by Intrinsic Pollen NADPH Oxidases Is Required for Inducing Allergic Airway Inflammation I. Boldogh1, A. Bacsi1, B. K. Choudhury2, N. Dharajiya2, R. Alam2, S. Sur2; 1Department of Microbiology and Immunology, UTMB, Galveston, TX, 2NIH Asthma and Allergic Diseases Research Center of Department of Internal Medicine, UTMB, Galveston, TX.

Poster Session 3413 Sunday, March 21 11:00 AM to 12:00 PM Eosinophils 560 Association Between Hypereosinophilia and Alopecia D. H. Jones1, T. J. Craig2; 1Internal Medicine, Creighton University Medical Center, Omaha, NE, 2Internal Medicine, Pennsylvania State University, Milton S. Hershey Medical Center, Hershey, PA. 561 An Atypical Protein Kinase C, PKC ζ, Regulates Human Eosinophil Effector Functions M. Kato1, A. Tachibana2, M. Suzuki2, Y. Tsuchida3, H. Kimura4; 1Department of Allergy, Gunma Children’s Medical Center, Hokkitsu, Gunma, JAPAN, 2Department of Pediatrics, Gunma University School of Medicine, Maebashi, JAPAN, 3Department of Surgery, Gunma Children’s Medical Center, Hokkitsu, Gunma, JAPAN, 4Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, JAPAN. 562 Clinical Presentation and Allergy Data in Patients With Eosinophilic Inflammation of the Esophagus S. Baxi1, F. Leickly2, N. Swigonski3, S. Gupta4; 1General Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University Medical Center, Indianapolis, IN, 2Division of Pulmonary, Allergy, and Critical Care, James Whitcomb Riley Hospital for Children, Indiana University Medical Center, Indianapolis, IN, 3Children’s Health Services Research, James Whitcomb Riley Hospital for Children, Indiana University Medical Center, Indianapolis, IN, 4Division of Gastroenterology, James Whitcomb Riley Hospital for Children, Indiana University Medical Center, Indianapolis, IN. 563 Effect of Pranlukast, a Cysteinyl Leukotriene-Receptor 1Antagonist, on Eosinophil Tranendothelial Migration M. Nagata, I. Kikuchi, K. Saito, K. Hagiwara, M. Kanazawa; Department of Respiratory Medicine, Saitama Medical School, Saitama, JAPAN. 564 Autocrine Activation of Eosinophil Transmigration With Cyteinyl Leukotrienes Y. Kato1, T. Fujisawa1, H. Kamiya1, O. Yoshie2; 1Institute for Clinical Research, National Mie Hospital, Tsu, JAPAN, 2Department of Microbiology, Kinki University, Osaka, JAPAN. 565 CpG Oligodeoxynucleotide Prolongs Human Eosinophil Survival Through Activation of NF-κB K. Matsumoto, S. Fukuda, M. Terakawa, A. Kato, H. Saito; Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, JAPAN.

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Relationship of In Vitro Survival and Eosinophil Derived Neurotoxin (EDN) Degranulation in Blood and Airway Eosinophils (EOS) Following Segmental Bronchoprovocation With Allergen (SBP-AG) J. B. Sedgwick1, K. Bartemes2, H. Kita2, W. W. Busse1; 1Department of Medicine, University of Wisconsin, Madison, WI, 2Department of Allergic Research, Mayo Clinic, Rochester, MN. Human Eosinophils Express IL-18 mRNA and Protein S. K. Mathur, J. B. Sedgwick, R. F. Vrtis, A. M. Brooks, W. W. Busse; University of Wisconsin Hospital and Clinics, Madison, WI. Three Cases of Idiopathic Hypereosinophilic Syndrome (IHES) Presenting as Lower Gastrointestinal Bleeding Y. Lim, S. Kyung, C. An, S. Lee, J. Park, S. Jeong; Internal Medicine, Division of Pulmory Medicine, Gachon Medical School, Ghil Medical Center, Incheon, REPUBLIC OF KOREA. Hypereosinophilic Syndrome Masking as a Hepato-Biliary Mass M. R. Reyes1, L. R. Carucci2, C. Abraham3, M. Abedi4, L. B. Schwartz1; 1Allergy & Immunology, Virginia Commonwealth University Health Systems, Richmond, VA, 2Radiology, Virginia Commonwealth University Health Systems, Richmond, VA, 3Internal Medicine, University of Virginia, Roanoke, VA, 4Gastroenterology, Washington Hospital Center, Washington, DC. Regulatory Role of the Carcinoembryonic Antigen (CEA)Family Molecules in the Innate Eosinophil Response to Staphylococcus aureus A. Terada1,2, H. Kita1; 1Department of Medicine and Immunology, Mayo Clinic, Rochester, MN, 2Department of Pediatrics, Nagoya City University School of Medicine, Nagoya, JAPAN. Donor to Donor Variation of the Chemokine Receptor CCR1 on Human Eosinophils and Its Prolonged Internalization by RANTES Y. Dulkys1, S. E. Escher2, J. Elsner1; 1Department of Dermatology and Allergology, Hannover Medical University, Hannover, GERMANY, 2Hannover Medical University, Hannover, GERMANY. Interleukin-5 (IL-5) and Fetal Bovine Serum (FBS) Induce Downregulation of CD30 Surface Expression but Not mRNA Expression in Human Blood Eosinophils A. I. Berro, D. K. Agrawal; School of Medicine, Creighton University, Omaha, NE. The Effect of PPAR gamma Agonists Thiazolidinediones on Eosinophil Function T. Adachi1, Y. Matsuwaki2, S. Ueki2, J. Chihara2, K. Ohta1; 1Dept. of Internal Medicine, Teikyo University School of Medicine, Tokyo, JAPAN, 2Dept. of Clinical and Laboratory Medicine, Akita University School of Medicine, Akita, JAPAN. Neurotrophins Have a Functional Role on Eosinophils in Atopic Dermatitis U. Raap1, C. Goltz1, N. Deneka1, H. Renz2, A. Kapp1, B. Wedi1; 1Department of Dermatology and Allergology, Hannover, GERMANY, 2Department of Clinical Chemistry and Molecular Diagnostics, Marburg, GERMANY. Modulation of the Level of Natural Antibodies to Endotoxin in Bronchial Asthma Patients Receiving Mite Allergen Immunotherapy V. A. Beloglazov1, L. K. Znamenskaya1, A. I. Gordienko1, A. V. Rosovenko1, L. M. DuBuske2; 1Crimean State Medical University, Simferopol, Crimea, UKRAINE, 2Immunology Research Institute of New England, Fitchburg, MA. Kinetics of GATA-1 Expression in Cord Blood Eosinophil Progenitors: Effects of Budesonide L. Crawford, A. J. Baatjes, M. M. Cyr, L. M. Hayes, J. A. Denburg; Department of Medicine, McMaster University, Hamilton, ON, CANADA. Suppression of CFU-eo Formation by Bone Marrow Stromal Cells and IL-4

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M. Hogan1, D. Piktel2, R. Simpson3, L. F. Gibson1, J. E. Welch1, K. S. Landreth2; 1Department of Pediatrics, West Virginia University, Morgantown, WV, 2Department of Microbiology and Immunology, West Virginia University, Morgantown, WV, 3West Virginia University, Morgantown, WV. The Development and Characterization of Novel EosinophilSpecific Polyclonal Antibody With Pan-Species Specificity That Includes Humans T. D. Nguyen1, K. A. Dobos-Elder2, S. A. Cormier1,3, E. M. H. Hulburd1, E. Lenkiewicz1, C. A. Protheroe1, D. M. Dimina1, S. I. Ochkur1, M. P. McGarry1,4, N. A. Lee1, J. J. Lee1; 1Mayo Clinic Arizona, Scottsdale, AZ, 2Colorado State University, Fort Collins, CO, 3Louisiana State University, Baton Rouge, LA, 4Arizona State University, Tempe, AZ. Detection of Mouse Eosinophils and Quantitative Assessments of Degranulation Using Secondary Granule Protein-Specific Polyclonal and Monoclonal Antibodies M. P. McGarry1,2, S. A. Cormier1,3, K. Dobos-Elder4, E. Lenkiewicz1, K. R. O’Neill1, D. C. Colbert1, C. A. Protheroe1, D. M. Dimina1, T. L. Biechele5, N. A. Lee1, J. J. Lee1; 1Mayo Clinic Arizona, Scottsdale, AZ, 2Arizona State University, Tempe, AZ, 3Louisiana State University, Baton Rouge, LA, 4Colorado State University, Fort Collins, CO, 5University of Washington, Seattle, WA. Eosinophils Differentially Accumulate in the Necrotic and Capsule Areas of Solid Tumors Independent of CD4+ T-Cell Activities T. D. Nguyen1, S. A. Cormier1,2, C. E. Bedient1, C. A. Protheroe1, D. M. Dimina1, S. I. Ochkur1, M. P. McGarry1,3, N. A. Lee1; 1Mayo Clinic Arizona, Scottsdale, AZ, 2Louisiana State University, Baton Rouge, LA, 3Arizona State University, Tempe, AZ. Upregulated Response to Chemokines in the Expression of Adhesion Molecules on Eosinophils From Allergic Patients S. Ueki, Y. Kamada, N. Saito, K. Yamaguchi, A. Kanda, K. Hamada, H. Kayaba, J. Chihara; Department of Clinical and Laboratory Medicine, Akita University School of Medicine, Akita, JAPAN. Human Peripheral Blood Eosinophils Express Functional CD2-Subfamily Immunoglobulin Receptors A. Munitz1, S. Fraenkel1, M. Colonna2, D. Pende3, L. Moretta4,5, F. Levi-Schaffer1; 1Department of Pharmacology, Hebrew University of Jerusalem, School of Pharmacy, Jerusalem, ISRAEL, 2Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, 3Istituto Nazionale per la Ricerca sul Cancro, Genova, ITALY, 4Dipartimento di Medicina Sperimentale, Universita’ degli Studi di Genova, Genova, ITALY, 5Istituto Giannina Gaslini, Genova, ITALY. Selective Activation of Human Eosinophils by Bacteria Belonging to Different Taxonomic Groups C. Wennerås1, L. Svensson2; 1Clinical Bacteriology/Hematology, Sahlgrenska University Hospital, Göteborg, SWEDEN, 2Clinical Bacteriology, Göteborg University, Göteborg, SWEDEN. Human Eosinophils Are Activated by Necrotic Epithelial Cells A. Stenfeldt1, C. Wennerås2; 1Clinical Bacteriology, Göteborg University, Göteborg, SWEDEN, 2Clinical Bacteriology/Hematology, Sahlgrenska University Hospital, Göteborg, SWEDEN. Allergens Directly Mobilize and Activate Human Eosinophils L. Svensson1, A. Rudin2, C. Wennerås3; 1Clinical Bacteriology, Göteborg University, Göteborg, SWEDEN, 2Rheumatology and Inflammation Research, Göteborg University, Göteborg, SWEDEN, 3Clinical Bacteriology/Hematology, Sahlgrenska University Hospital, Göteborg, SWEDEN. Epidermal Allergen Sensitization Primes for Aeroallergen Induced Eosinophilic Esophagitis (EE) L. M. Hassman, A. Mishra, H. Saito, M. Doepker, M. E. Rothenberg; Allergy, Cincinnati Children’s Hospital, Cincinnati, OH. Beneficial Effects of Eosinophils in Colitis Induced by Dextran Sulfate Sodium

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T. Kobayashi, K. Iijima, H. Kita; Division of Allergy, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, MN. Effect of Suplatast Tosilate (IPD) on Chloride Currents in Human Blood Eosinophils G. Cheng1, M. Kim1,2, A. Berro1,2, D. K. Agrawal1,2; 1Department of Internal Medicine, Allergy, Creighton University School of Medicine, Omaha, NE, 2Medical Microbiology and Immunology and Biomedical Sciences, Creighton University School of Medicine, Omaha, NE. Human Eosinophils Regulate T-Cell Functions Through Induction of Indoleamine 2,3-Dioxygenase S. O. Odemuyiwa1, A. G. Ghahary1, L. Puttagunta2, Y. Li3, A. Ghahary3, R. Moqbel1; 1Department of Medicine, Pulmonary Research Group, University of Alberta, Edmonton, AB, CANADA, 2Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, CANADA, 3Department of Surgery, University of Alberta, Edmonton, AB, CANADA. Serum Eosinophil Cationic Protein (ECP) Elevation Correlates With Asthma Symptoms and Reduced FEV1 in an Outpatient Screening Population A. Oughourli1, M. Michelis2, T. Selvaggi2, A. Sailon2; 1Hackensack University Medical Center, Hackensack, NJ, 2The Center for Allergy, Asthma and Immune Disorder, Hackensack University Medical Center, Hackensack, NJ. SNARE Isoforms in Granule-Derived Mediator Secretion From Human Eosinophils and Neutrophils: A Conserved Mechanism for Granule Docking? M. R. Logan, S. O. Odemuyiwa, F. Davoine, M. Steward, P. Lacy, R. Moqbel; Department of Medicine, University of Alberta, Edmonton, AB, CANADA. Hydroxychloroquine (HCQ) Treatment of Eosinophils Blocks IL-5 and Eotaxin-Promoted Functions and Induces Early Apoptosis B. L. Charous1, J. L. Bankers-Fulbright2; 1Allergy and Respiratory Care Center, Advanced Healthcare, Milwaukee Medical Clinic, Milwaukee, WI, 2Department of Medicine, Allergic Diseases Research Laboratory, Mayo Clinic, MN.

Oral Abstract Session 3601 Sunday, March 21 1:30 PM to 2:45 PM Inflammation in Asthma 1:30 593 Maintenance of Airway Hyperresponsiveness in Chronic Asthma May Be Mediated by Th2-Independent Mechanisms N. J. Lin1, J. R. Baker, Jr.1, J. M. Schuh2, C. M. Hogaboam2; 1Division of Allergy and Immunology, University of Michigan, Ann Arbor, MI, 2Department of Pathology, University of Michigan, Ann Arbor, MI. 1:45 594 Isolated Late Asthmatic Reactions Provoked by Inhalation of T-Cell Peptide Epitopes Are Associated With Bronchial Mucosal Infiltration of CD4+ T Cells and Increased Airway Hyperresponsiveness F. R. Ali, W. K. Tse, F. Benyahia, M. Larché, A. B. Kay; Allergy and Clinical Immunology, Imperial College London, NHLI Division, London, UNITED KINGDOM. 2:00 595 Association Between TNF and TGF Gene Polymorphisms in Infants and Family History of Allergic Rhinitis and Asthma A. Patel1, D. Gentile1, J. Trecki1, J. Howe-Adams1, A. Zeevi2, W. Doyle2, D. Skoner1; 1Department of Pediatrics, Allegheny General Hospital, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA.

2:15 596 Allergen-Induced Injury to the Epithelial Mesenchymal Trophic Unit in Mild Atopic Asthmatics S. Phipps, F. Benyahia, T. T. Ou, J. Barkans, A. B. Kay; Allergy and Clinical Immunology, Imperial College, NHLI Division, London, UNITED KINGDOM. 2:30 597 Inhalation of Interleukin-5 Induces an Increase in Bronchial Mucosal Eosinophils in Non-Asthmatics and Increased Release of CD34/CCR3+ Cells From the Bone Marrow of Asthmatics A. Menzies-Gow, P. Flood-Page, D. S. Robinson, A. B. Kay; Allergy and Clinical Immunology, Imperial College, NHLI Division, London, UNITED KINGDOM.

Oral Abstract Session 3602 Sunday, March 21 1:30 PM to 2:45 PM Treatment and Sinus Imaging Findings in Rhinitis 1:30 598 Does Abnormal Sinus X-ray Findings Mean Infection in Allergic Rhinitis Patients? J. A. Rizzo, A. R. Silva, R. Queiroz, E. S. C. Sarinho; Centro de Pesquisas em Alergia e Imunologia em Pediatria - Disciplina de Pediatria, Universidade Federal de Pernambuco, Recife, BRAZIL. 1:45 599 A Comparison of Rofleponide Palmitate Nasal Spray (RPNS) With Placebo and Mometasone Furoate Nasal Spray (MFNS) in Adolescent and Adult Patients With Seasonal (Mountain Cedar) Allergic Rhinitis (AR) D. A. Atkinson1, T. Uryniak2, B. Simpson2, L. O’Dowd2; 1Oklahoma Allergy & Asthma Clinic, Oklahoma City, OK, 2AstraZeneca LP, Wilmington, DE. 2:00 600 Recommended Once-Daily Dose of Budesonide Aqueous Nasal Spray (Rhinocort Aqua®) Does Not Suppress Growth Velocity in Pediatric Patients With Perennial Allergic Rhinitis K. R. Murphy1, T. Uryniak2, B. Simpson2, L. O’Dowd2; 1Midwest Allergy and Asthma Clinic, Omaha, NE, 2AstraZeneca LP, Wilmington, DE. 2:15 601 Phototherapy for Hay Fever - A New Therapeutic Tool for the Management of Allergic Rhinitis A. I. Koreck1, Z. Csoma1, F. Ignacz2, Z. Bor2, G. Szabo2, L. Bodai1, E. Kadocsa3, A. Dobozy1, L. Kemeny1; 1Department of Dermatology and Allergology, University of Szeged, Szeged, HUNGARY, 2Department of Optics and Quantum Electronics, University of Szeged, Szeged, HUNGARY, 3Department of OtoRhino-Laryngology and Head-Neck Surgery, University of Szeged, Szeged, HUNGARY. 2:30 602 Omalizumab, an Anti-IgE Antibody, Improves Both Asthmaand Rhinitis-Related Quality of Life in Patients With Concomitant Moderate-Severe Disease U. Harnest1, L. Boulet2, S. Hedgecock3, M. Blogg3, K. Surrey3, H. Fox3; 1CLIN-GUARD GMBH, Munich, GERMANY, 2Institut de cardiologie et de pneumologie de l’Universite Laval, Quebec City, PQ, CANADA, 3Clinical Development, Novartis Horsham Research Centre, Horsham, UNITED KINGDOM.

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3603 Sunday, March 21 1:30 PM to 2:45 PM Innate Immunity 1:30 603 Inhibitory Effect of CpG on IgE Production by Id2-Deficient B cells T. Kusunoki1, M. Sugai2, M. Kusunoki2, Y. Yokota3, T. Nakahata1, A. Shimizu2,4; 1Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, JAPAN, 2The Center for Molecular Biology and Genetics, Kyoto University, Kyoto, JAPAN, 3Department of Biochemisty, Fukui Medical School, Fukui, JAPAN, 4Translational Research Center, Kyoto University Hospital, Kyoto, JAPAN. 1:45 604 MyD88 Dependent Induction of Th2 Responses in a Mouse Model of Asthma D. A. Piggott; Section of Immunobiology, Yale University School of Medicine, New Haven, CT. 2:00 605 Alpha-Defensins NHP-1 and NHP-2 Induce Strong PlateletActivation Leading to CD40L Expression B. E. Kehrel, M. Horn, M. F. Brodde, K. Jurk, S. Niemann, H. K. Van Aken; Anaesthesiology and Intensive Care, Universityhospital Münster, Muenster, GERMANY. 2:15 606 CpG-B Directly Induces CXCR3 Chemokines via IFN-Independent, NF-κB- and p38-Dependent Pathways in Human B Lymphocytes A. Kato1,2, T. Homma1, T. Ogasawara1, H. Saito1, K. Matsumoto1; 1Allergy and Immunology, National Research Institute for Child Health & Development, Tokyo, JAPAN, 2Nikken Chemicals Co Ltd, Saitama, JAPAN. 2:30 607 Human Respiratory Tract Dendritic Cells Are Susceptible to Modulation by GM-CSF: Induction of a Th2 Profile in Naïve CD4+ T Cells A. Faith1, J. McDonald1, D. Richards1, E. Chevretton2, D. Roberts2, T. Lee1, C. Corrigan1, C. Hawrylowicz1; 1Asthma, Allergy and Respiratory Medicine, King’s College, London, UNITED KINGDOM, 2Ear, Nose and Throat, King’s College, London, UNITED KINGDOM.

Oral Abstract Session 3604 Sunday, March 21 1:30 PM to 2:45 PM Ocular Allergy: Mechanisms of Inflammation and Therapy 1:30 608 Mitogenic and Anti-apoptotic Effects of IL-4 and IL-13 on Human Conjunctival Fibroblasts N. Kumagai1, Y. Fujitsu1, K. Fukuda2, K. Seki2, T. Nishida1; 1Department of Biomolecular Recognition and Opthalmology, Yamaguchi University, Ube, JAPAN, 2Department of Ocular Pathophysiology, Yamaguchi University, Ube, JAPAN. 1:45 609 Stimulation of Interleukin-6 Production by Human Conjunctival Epithelial Cells (HCEC) With Thrombin and Tryptase T. J. Nickel, M. H. Kabir, J. Talreja, K. Dileepan, D. J. Stechschulte; Allergy, Immunology, and Rheumatology, University of Kansas, Kansas City, KS. 2:00 610 Regulation of Mast Cell Degranulation in Allergic Eye Disease by IL-10

A. M. Keane-Myers1, B. Wetzel1, K. Druey2, V. Bundoc1; 1NIH/NIAID/LAD/EBS, Rockville, MD, 2NIH/NIAID/LAD/MSTS, Rockville, MD. 2:15 611 Duration of Ascaris Infection Modulates Allergic Disease in a Mouse Model of Allergic Conjunctivitis B. J. Wetzel1, L. Schopf2, V. Bundoc1, J. Urban2, A. KeaneMyers1; 1National Institute of Allergy and Infectious Diseases, Rockville, MD, 2USDA, Beltsville, MD. 2:30 612 Vernal Keratoconjunctivitis: Result of a Novel Therapy With 0.1% Topical Ophthalmic FK-506 Ointment P. Dumrongkigchaiporn1, P. Kosrirukvongs2, C. Tantimongkolsuk1, O. Jirapongsananuruk1, N. Visitsunthorn1, P. Vichyanond1; 1AI/Imm Div, Dept Pediatrics, Siriraj Hospital, Bangkok, THAILAND, 2Dept Ophthalmology, Siriraj Hospital, Bangkok, THAILAND.

Oral Abstract Session 3605 Sunday, March 21 1:30 PM to 2:45 PM Environmental Control for Asthma Management in Inner Cities 613 Environmental Intervention Reduces Mouse Allergen Levels in Homes of Boston Inner-City Children With Asthma B. Cronin1, R. Tachdjian2, H. C. Oettgen1, R. A. Wood3, P. A. Eggleston3, M. Shih4, L. Song1, W. Phipatanakul1; 1Immunology and Allergy, Children’s Hospital, Boston, Harvard Medical School, Boston, MA, 2Pediatrics, Massachusetts General Hospital, Boston, MA, 3Allergy and Immunology, Johns Hopkins University, Baltimore, MD, 4Biostatistics, Harvard School of Public Health, Boston, MA. 614 Does a Multifaceted Environmental Intervention Alter the Effect of Asthma Among Inner-City Children? S. G. Williams, K. H. Falter, C. J. Alverson, C. Brown, S. Redd; National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA. 615 Abatement of Cockroach Allergens (Bla g 1 and Bla g 2) in Low-Income, Urban Housing: 12-Month Continuation Results M. Sever1, S. Arbes, Jr.1, J. Mehta1, J. C. Gore2, C. Schal2, B. Vaughn3, H. Mitchell3, D. C. Zeldin1; 1NIEHS, Research Triangle Park, NC, 2North Carolina State University, Raleigh, NC, 3Rho, Inc., Chapel Hill, NC. 616 Home Environmental Treatment Improves Asthma in Inner City Children P. A. Eggleston1, P. A. Eggleston1, A. Butz1, C. Rand2, L. Swartz1, K. Callahan1, J. Curtin-Brosnan1, B. Merriman2, M. Huffman1, P. Breysse3, T. Buckley3, G. Diette2, J. Krishnan4, S. Kanchanaraksa5; 1Pediatrics, Johns Hopkins University, Baltimore, MD, 2Medicine, Johns Hopkins University, Baltimore, MD, 3Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 4Medicine, Johns Hopkins University, Baltimore, MT, 5Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. 617 Efficacy of Sodium Hypochlorite Disinfectant on the Viability and Allergenic Properties of Household Mold K. A. Reynolds1, S. Boone2, K. Bright1, C. P. Gerba1; 1Department of Soil, Water and Environmental Science, The University of Arizona, Tucson, AZ, 2Department of Public Health and Epidemiology, The University of Arizona, Tucson, AZ.

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Oral Abstract Session 3606 Sunday, March 21 1:30 PM to 2:45 PM

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Adverse Reactions to Drugs and Vaccines 1:30 618 Penicillin Skin Testing in the Pediatric Outpatient Setting B. C. Jost1,2, G. R. Bloomberg1,3; 1Division of Allergy and Immunology, Washington University School of Medicine, St. Louis, MO, 2St. Louis Children’s Hospital, St. Louis, MO, 3Division of Allergy and Pulmonary Medicine, St. Louis Children’s Hospital, St. Louis, MO. 1:45 619 Patients With Sulfonamide Antimicrobial “Allergy”: Are They Able to Tolerate Sulfonamide-Containing Non-Antimicrobial Agents? M. Morgan, R. S. Gruchalla, H. S. Earl; Allergy & Immunology, UT Southwestern, Dallas, TX. 2:00 620 Selective COX-2 Inhibitors: A Safety Alternative for Patients With Intolerance to Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) D. Giamarchi, R. Escamilla, S. Carme, M. Krempf; Pneumology and Allergology, Hôpital Purpan, Toulouse, FRANCE. 2:15 621 Lost of Sensitivity to Diphteria-Tetanus Vaccine Over Time M. Primeau, A. Des Roches; Pediatric Department, Sainte-Justine Hospital, University of Montreal, Montreal, PQ, CANADA. 2:30 622 Reactivity of IgE and IgG Antibodies to Human Collagen Type I in Children With Bovine Gelatin Allergy M. Sakaguchi1, H. Miyazawa2, H. Hori3, T. Ebihara4, S. Hattori4, S. Irie4, S. Inouye5; 1National Institute of Infectious Diseases, Tokyo, JAPAN, 2Kyorin University, Tokyo, JAPAN, 3Tokyo Medical and Dental University, Tokyo, JAPAN, 4Nippi Research Institute of Biomatrix, Tokyo, JAPAN, 5Otsuma University, Tokyo, JAPAN.

Oral Abstract Session 3607 Sunday, March 21 1:30 PM to 2:45 PM Epidemiology 1:30 623 The Variances in Histamine Control Skin-Testing Response Between Asian/Pacific Islanders and Other Racial Groups V. H. Chou1, M. Lee-Wong2, R. Wong3, H. W. Cohen4; 1Medicine, Beth Israel Medical Center, New York, NY, 2Allergy/Immunology, Beth Israel Medical Center, New York, NY, 3Beth Israel Medical Center, New York, NY, 4Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY. 1:45 624 Prevalence of Obstructive Airway Disease Among Self-Reporting County and State Fair Attendees in Iowa D. M. Coleman, Jr., D. Pfab, S. Reed, Z. K. Ballas, I. Hussain; University of Iowa, Iowa City, IA. 2:00 625 Prevalence of the Epidemiological Markers of Asthma in Schoolchildren in Georgia A. G. Gamkrelidze1, M. A. Gotua2, M. T. Rukhadze2, T. G. Abramidze2; 1Ministry of Labor, Health and Social Affairs, Tbilisi, GEORGIA, 2Center of Allergy & Immunology, Tbilisi, GEORGIA.

2:15 626 NAEPP Severity Classification as a Measure of Disease Burden in Children With Acute Asthma M. Kwok1, M. Gorelick1, C. M. Walsh-Kelly1, L. Grabowski2, K. J. Kelly2; 1Pediatric Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, 2Allergy/Immunology, Medical College of Wisconsin, Milwaukee, WI. 2:30 627 Parent and Child Reports of Asthma Symptoms, Activity Limitations and Emotional Distress: Early Results From the Child Health Information Reporting Project (CHIRP) L. Asmussen1, K. B. Weiss2, D. Elfring2, L. M. Olson1; 1American Academy of Pediatrics, Elk Grove Village, IL, 2Feinberg School of Medicine, Northwestern University, Chicago, IL.

Oral Abstract Session 3608 Sunday, March 21 1:30 PM to 2:45 PM Signaling in Inflammatory Cells 1:30 628 FcεRI-Mediated-Activation of PLC-γ Is Not Defective in Mouse Bone Marrow-Derived Mast Cells (BMMC) Lacking PI-3 Kinase-p85α or p85β Gene Products C. Tkaczyk1, M. A. Beaven2, S. Brachman3, D. D. Metcalfe1, A. M. Gilfillan1; 1Niaid, Laboratory of Allergic Diseases, Bethesda, MD, 2Nhlbi, Laboratory of Molecular Immunology, Bethesda, MD, 3Harvard Medical School and Division Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA. 1:45 629 Reduced Airway Inflammation, Mucus Production and Airway Remodeling in MAP Kinase-Activated Protein Kinase (MK2) Knockout Mice M. M. Gorska1, S. Stafford2, N. Dharajiya2, Q. Liang1, S. Sur2, M. Gaestel3, R. Alam1; 1Medicine, National Jewish Medical and Research Center, Denver, CO, 2Medicine, University of Texas Medical Branch, Galveston, TX, 3Medicine, Hannover Medical School, Hannover, GERMANY. 2:00 630 Gene Deletion of Rac2 Leads to Defective Primary Granule Translocation in Neutrophils P. Lacy, D. Abdel Latif, M. Steward; Department of Medicine, University of Alberta, Edmonton, AB, CANADA. 2:15 631 Regulation of STAT6 by Interferon- (IFN-) γ in Human Airway Epithelial Cells N. M. Heller1, S. Matsukura2, S. N. Georas1, M. Boothby3, C. Stellato1, R. P. Schleimer1; 1Johns Hopkins Asthma/Allergy, Baltimore, MD, 2Showa University, Tokyo, JAPAN, 3Vanderbilt University, Nashville, TN. 2:30 632 Cytokine-Mediated Regulation of Toll-like Receptor Expression in Eosinophils H. Nagase1, S. Okugawa2, Y. Ota2, M. Yamaguchi2, H. Tomizawa3, K. Matsushima 2, K. Ohta 1, K. Yamamoto2, K. Hirai2; 1Teikyo University School of Medicine, Tokyo, JAPAN, 2University of Tokyo, Tokyo, JAPAN, 3Japan Energy Corporation, Saitama, JAPAN.

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4401 Monday, March 22 11:00 AM to 12:00 PM Mechanisms of Asthma 633 The Effect of Daily Budesonide Therapy on IL-10 in a Murine Model of Asthma K. S. Konduri1, S. D. Nandedkar1, D. A. Rickaby2, J. D. Henderson3, N. Duzgunes4; 1Pediatrics, Medical College of Wisconsin, Milwaukee, WI, 2Physiology, Zablocki VA Medical Center, Milwaukee, WI, 3Surgery, Zablocki VA Medical Center, Milwaukee, WI, 4Microbiology, University of the Pacific School of Dentistry, San Francisco, CA. 634 Eosinophil Cells and Eosinophil Peroxidase Composition in Sputa of Severe Asthmatic Patients Before and After Systemic Steroid Therapy W. Sarti; Faculdade de Medicina de Ribeirão Preto - Division of Clinical Immunology, University of São Paulo, Ribeirão Preto, BRAZIL. 635 Phosphorylated Stat-6 Levels in Human Nasal Epithelial (HNE) Cells in Acute and Controlled Asthmatic Children M. D. Stevenson1, M. O. Daines2, R. M. Ruddy1, G. K. Khurana Hershey2; 1Division of Emergency Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. 636 Expression of CD163 in Asthmatic Patients During Specific Bronchial Challenge With Dermatophagoides Pteronyssinus (Dp) Allergen K. Kowal1, S. Zukowski1, L. M. DuBuske2, A. BodzentaLukaszyk1; 1Department of Allergology and Internal Medicine, University Medical School of Bialystok, Bialystok, POLAND, 2Immunology Research Institute of New England, Fitchburg, MA. 637 Evaluation of Exhaled Nitric Oxide and Nitric Oxide Metabolites in Exhaled Breath Condensate During Asthma D. Jourd’heuil1, F. L. Jourd’heuil1, K. S. Patil2, A. Harish2, P. J. Feustel3, H. Jafri4, M. A. Pasha2; 1Center for Cardiovascular Diseases, Albany Medical College, Albany, NY, 2Allergy, Asthma, & Immunology Center, Albany Medical College, Albany, NY, 3Center for Neuropharmacology & Neuroscience, Albany Medical College, Albany, NY, 4Division of Pediatric Infectious Diseases, U.T. Southwestern Medical Center at Dallas, Dallas, TX. 638 Resistin-Like Molecule (RELM)-Alpha and Beta Are AllergenInduced Cytokines With Potent Remodeling Activity in the Murine Lung A. Mishra1, C. W. DeBrosse2, M. E. Rothenberg1; 1Allergy and Immunology, Cincinnati Childrens Hospital Medical Center, Cincinnati, OH, 2University of Cincinnati, Collage of Medicine, Cincinnati, OH. 639 Effect of IL-13 and IL-13 Blocker (mIL-13Rα2) on Airway Smooth Muscle (ASM) N. M. A. Qutna; Medicine-Allergy-Biomedical sciences, Creighton Univ. Sch. of Med., Omaha, NE. 640 Neuroimmune Dysregulation in a Mouse Model for Allergic Asthma C. Hahn, S. Kerzel, H. Renz, W. A. Nockher; Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps University, Marburg, GERMANY. 641 Comparison of Airway and Peripheral Blood T Cell Characteristics in Severe Asthma and COPD J. C. Ratoff1, M. I. Allenby1, M. W. Lethbridge1, W. Turnbull2, A. C. L. Cheung1, T. Snape1, A. C. Hayday2, C. J. Corrigan1, B. J. O’Connor1; 1Asthma, Allergy and Respiratory Science, King’s College, London, UNITED KINGDOM, 2Immunobiology, King’s College, London, UNITED KINGDOM.

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Susceptibility to Asthma Phenotype in Human Airway Smooth Muscle Mannose Receptor (huASM-MR) Transgenic Mice W. Robinson, Jr.1, C. Michael1, T. Overbeck1, F. Kirkland1, E. Bonten2, A. d’Azzo1, B. Lew1; 1Pediatrics, University of Tennessee, Memphis, TN, 2Genetics, St Jude Research Children’s Hospital, Memphis, TN. Eotaxin/CCL11, RANTES/CCL5 and MCP-1/CCL2 Modulate Airway Fibroblast Properties In Vitro I. Puxeddu1, N. Berkman2, F. Levi-Schaffer1; 1Dep. of Pharmacology, School of Pharmacy The Hebrew University of Jerusalem, Jerusalem, ISRAEL, 2Institute of Pulmonology, Hadassah-University Hospital and Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, ISRAEL. Local and Systemic Responses in Murine Experimental Allergic Airways Inflammation: Mechanisms Linking Rhinitis to Asthma J. Li, H. Saito, L. Crawford, J. A. Denburg; Medicine, McMaster University, Hamilton, ON, CANADA. Quantitative Analysis of IgE Antibodies Food and Inhalant Allergens in Children 4 Years Old Reflects the Likelihood of Allergic Disease M. Wickman1, S. Ahlstedt1, G. Lilja2, M. van Hage Hamsten3; 1National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SWEDEN, 2Institutionen Södersjukhuset, Karolinska Institutet, Stockholm, SWEDEN, 3Institute of Medicine, Karolinska Institutet, Stockholm, SWEDEN. Leukotrienes and Prostanoids in Exhaled Breath Condensate in Childhood Asthma P. Montuschi1, C. Mondino2, R. Pistelli3, A. Trové3, P. Koch4, G. Ciabattoni5; 1Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, ITALY, 2Department of Immunodermatology, Istituto Dermopatico dell’Immacolata, IDI, Rome, ITALY, 3Department of Internal Medicine and Geriatrics, Catholic University of the Sacred Heart, Rome, ITALY, 4Department of Respiratory Medicine, Ospedale Pediatrico Bambino Gesù, Palidoro, ITALY, 5Department of Drug Sciences, School of Pharmacy, University of Chieti, Chieti, ITALY. Effects of Mycobacterium vaccae on Toll-like Receptor Expression R. Martinelli1, V. C. Adams2, G. A. W. Rook2, L. Rosa Brunet1; 1SR Pharma, London, UNITED KINGDOM, 2Department of Medical Microbiology, University College London, London, UNITED KINGDOM. Co-Expression of Eotaxin-2 and IL-5 in Double Transgenic Mice Leads to Eosinophil Degranulation and the Development of Pulmonary Pathologies S. I. Ochkur1, T. L. Biechele2, B. McElhinney3, C. A. P1, R. S. Pero1, M. T. Borchers1,4, K. R. O’Neill1, D. C. Colbert1, M. P. McGarry1,5, Y. Janssen-Heininger3, C. R. Irvin3, H. H. Shen1,6, N. A. Lee1, J. J. Lee1; 1Mayo Clinic Arizona, Scottsdale, AZ, 2University of Washington, Scottsdale, WA, 3Vermont Asthma Center, Burlington, VT, 4University of Cincinnati, Cincinnati, OH, 5Arizona State University, Tempe, AZ, 6Second Hospital, Zhejiang University, Hangzhou, CHINA. CD69 Expression on Eosinophils Is a Marker of Activation in the Lung Following Allergen Provocation H. Wang1,2, S. I. Ochkur1, M. P. McGarry1,3, K. R. O’Neill1, D. C. Colbert1, S. A. Cormier1,4, N. A. Lee1, H. H. Shen1,2, J. J. Lee1; 1Mayo Clinic Arizona, Scottsdale, AZ, 2Second Hospital, Zhejiang University, Hangzhou, CHINA, 3Arizona State University, Tempe, AZ, 4Louisiana State University, Baton Rouge, LA. Indoor Degree of Cockroach Infestation and Asthma E. S. C. Sarinho, D. Schor, M. A. Veloso, J. A. Rizzo; Centro de Pesquisas em Alergia e Imunologia em Pediatria - Disciplina de Pediatria, Universidade Federal de Pernambuco, Recife, BRAZIL. Alterations in the Lung Distribution of Hyaluronan and Versican in a Murine Model of Asthma

MONDAY

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T. S. Wilkinson1, E. Chi2, W. Henderson, Jr.2, S. Lara3, S. PotterPerigo1, M. Merrilees4, L. Altman1, T. Wight1; 1Vascular Biology, Hope Heart Institute, Seattle, WA, 2Department of Medicine, University of Washington, Seattle, WA, 3Department of Pathology, University of Washington, Seattle, WA, 4Department of Anatomy and Radiology, University of Auckland, Auckland, NEW ZEALAND. Cytokine Production If Circulating Lymphocytes From Children Treated for Wheezing in the Emergency Department (ED) M. S. Shaker1, H. T. Carper1, W. Woods1, L. Borish2, J. F. Hunt1, F. G. Hayden2, T. A. E. Platts-Mills2, P. W. Heymann1; 1Pediatrics, University of Virginia, Charlottesville, VA, 2Internal Medicine, University of Virginia, Charlottesville, VA. Expression of Interleukin (IL)-17F in a Mouse Model of Asthma S. Suzuki1, F. Kokubu1, M. Odaka1, S. Watanabe1, K. Ieki1, M. Kawaguchi1, S. Matsukura1, M. Kurokawa1, M. Adachi1, H. Ota2; 11st Department of Internal Medicine, Showa University, Tokyo, JAPAN, 22nd Department of Pathology, Showa University, Tokyo, JAPAN. Expression of Th Cytokine-Associated Transcription Factors in the PBMCs of Atopic Asthmatics Y. Jee1, Y. Kim1, J. Park1, K. Lee1, H. Kwon2; 1Department of Internal Medicine, Dankook University College of Medicine, Cheonan, REPUBLIC OF KOREA, 2Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, REPUBLIC OF KOREA. Exhaled Eicosanoids Following Oral Aspirin Challenge in Patients With Asthma M. Sanak, B. Kielbasa, G. Bochenek, K. Nagraba, A. Szczeklik; Department of Medicine, Jagiellonian University Medical School, Cracow, POLAND. Angiogenesis in Response to Allergen Challenge in a Murine Model of Asthma S. S. Aceves, S. Y. Lee, J. Y. Cho, D. H. Broide; Division of Allergy, Immunology, University of California, San Diego, La Jolla, CA. An Important Role for Relaxin-1 in the Regulation of Airway Fibrosis and Airway Hyperresponsiveness in an Animal Model of Asthma M. L. Tang1, M. Burton1, G. W. Tregear2, C. S. Samuel2; 1Department of Immunology, Royal Children’s Hospital, Melbourne, AUSTRALIA, 2Howard Florey Institute of Experimental Physiology & Medicine, University of Melbourne, Melbourne, AUSTRALIA. Eformoterol Fumarate & Sodium Cromoglycate (SCG) Inhibit the Airway Response to Inhaled Mannitol in Asthmatics by Mast Cell Inhibition J. D. Brannan1, M. Gulliksson2, S. D. Anderson1, N. Chew3, J. P. Seale4, M. Kumlin2; 1Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, AUSTRALIA, 2Division for Experimental Asthma & Allergy Research, Karolinska Institutet, Stockholm, SWEDEN, 3Department of Pharmacy, University of Sydney, Sydney, AUSTRALIA, 4Department of Pharmacology, University of Sydney, Sydney, AUSTRALIA. Enantiomers of Beta-Agonists Exhibit Differential Effects in Combination With Dexamethasone on GM-CSF Production in Human Airway Smooth Muscle Cells B. T. Ameredes, A. L. Gligonic, W. J. Calhoun; AAARC: Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA. Plasmin and the Regulation of TGF-β1 Bioavailability in Asthma M. G. Buckley, L. C. Lau, T. J. Shaw, P. H. Howarth; Rcmb, University of Southampton, Southampton, UNITED KINGDOM.

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PPAR-γ Activity Is Deficient in Alveolar Macrophages of Allergic Asthmatics T. E. Rambasek1, M. T. Follettie2, I. W. Wang2, S. Wei2, J. Cai2, T. L. Bonfield1, A. Malur1, B. P. Barna1, T. Isabella1, S. L. Goldman2, M. S. Kavuru1, M. Kobayashi2, M. Thomassen1; 1Pulmonary, Cleveland Clinic Foundation, Cleveland, OH, 2Inflammation Research, Wyeth, Cambridge, MA. Anti-IgE Inhibition of Antigen-Stimulated Human Bronchial Epithelial Cells (BEC) Release of Proinflammatory Cytokines M. Frieri1,2, Y. Huang1; 1Nassau University Medical Center, East Meadow, NY, 2State University of New York at Stony Brook, Stony Brook, NY. German Cockroach Extract Induces [Ca2+] Oscillations From Thapsigargin-Sensitive Ca2+ Stores via Protease Activated Receptor-2 in Human Airway Epithelial Cells M. Sohn1, J. Hong2, K. Kim1, D. Shin2; 1Department of Pediatrics, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA, 2Yonsei University College of Dentistry, Seoul, REPUBLIC OF KOREA. Markers of Eosinophil Activation in Fasting Gastric Juice in Infants With Wheezing Episodes N. Tomac1, C. Acun2, B. D. Gun3, I. Tekin4, A. Sogut2, S. Cavuldak2; 1Pediatric Allergy, Zonguldak Karaelmas University, Zonguldak, TURKEY, 2Pediatrics, Zonguldak Karaelmas University, Zonguldak, TURKEY, 3Pathology, Zonguldak Karaelmas University, Zonguldak, TURKEY, 4Immunology, Zonguldak Karaelmas University, Zonguldak, TURKEY. Complement Does Not Exhibit Abnormal Sensitivity to Activation via the Classical, Alternative, or Lectin Pathway in Subjects With Asthma S. K. Wust1, M. N. Blumenthal1, B. Benson2, A. P. Dalmasso2; 1Medicine, University of Minnesota, Minneapolis, MN, 2Surgery, University of Minnesota, Minneapolis, MN. Dust Mite (DM) Allergen and IL-1b-Stimulated Human Alveolar Epithelial Cells (A549) Secrete Vascular Endothelial Growth Factor (VEGF) A. Capetandes1, L. Xie2, Y. Huang1, M. Frieri1,3; 1Division of Allergy Immunology, Nassau University Medical Center, East Meadow, NY, 2Dept of Pathology, Nassau University Medical Center, East Meadow, NY, 3SUNY Stony Brook, Stony Brook, NY. Modulation of IL-8 mRNA Expression and Production in Respiratory Syncytial Virus (RSV) Stimulated Human Alveolar Epithelial Cells by Budesonide and Montelukast N. S. Horne1, H. Shaw1, Y. Huang1, M. Frieri1,2; 1Internal Medicine/Pathology, Nassau University Medical Center, East Meadow, NY, 2Internal Medicine/Pathology, SUNY Stony Brook, Stony Brook, NY. Nitric Oxide (NO) Production by Human Bronchial Epithelial Cells (BEC) – Modulation by Anti-IgE B. T. Leyko1, Y. Huang1, M. Frieri1,2; 1Nassau University Medical Center, East Meadow, NY, 2Internal Medicine/Pathology, SUNY Stony Brook, Stony Brook, NY. Assessment of a Protocol for Sputum Freezing and Subsequent Examination T. A. Popov1, A. Petlichkovski2, T. B. Mustakov1, L. M. DuBuske3, D. N. Popova1; 1Allergology, Medical University Sofia, Sofia, BULGARIA, 2Medical Faculty, University, Skopje, THE FORMER YUGOSLAV REPUBLIC OF MACEDONIA, 3Immunology Research Institute of New England, Fitchburg, MA. IgA Sensitizes Airway Smooth Muscle to Histamine J. Richman-Eisenstat, K. Grant, J. Yu, R. Bose; Manitoba Institute of Cell Biology, Depts. of Medicine and Pharmacology, University of Manitoba, Winnipeg, MB, CANADA. A2B Adenosine Receptors Mediate Human Lung Fibroblast Differentiation via Releasing IL-6 H. Zhong, L. Belardinelli, T. Maa, D. Zeng; Department of Drug

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682A Prevalence of Asthma and Inhalant Allergy Symptoms Among Recreational Road Runners C. C. Randolph, D. Dreyfus, B. Fraser, J. Olson; Allergy/, Yale/Waterbury Affiliate, Waterbury, CT.

Poster Session 4402 Monday, March 22 11:00 AM to 12:00 PM Clinical Advances in Rhinitis and Sinusitis 683 A Placebo-Controlled Evaluation of Butterbur and Fexofenadine on Objective and Subjective Outcomes in Perennial Allergic Rhinitis R. D. Gray, D. K. C. Lee, F. M. Robb, S. Fujihara, B. J. Lipworth; Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UNITED KINGDOM. 684 Desloratadine Inhibits GM-CSF Secretion From Nasal Mucosa and Polyps and Eosinophil Survival Induced by Epithelial Cells J. Mullol1, J. Roca-Ferrer2, G. Güell2, I. Alobid1, P. Benítez1, M. Bernal1, A. L. Valero3, C. Picado3; 1ENT Department, Hospital Clínic, Barcelona, SPAIN, 2Clinical and Experimental Respiratory Immunoallergy, IDIBAPS, Barcelona, SPAIN, 3Pneumology & Allergy Department, Hospital Clínic, Barcelona, SPAIN. 685 The Correlation Between Upper and Lower Respiratory Inflammation D. Han, X. Wang, B. Zhou, Y. Wei; Department of Otolaryngology, Beijing TongRen Hospital, Beijing, China, CHINA. 686 Effects of Intranasal Fluticasone and Salmeterol on AllergenInduced Nasal Inflammation and Nasal Electrical Potential in Allergic Rhinitis A. Fanat, K. Parameswaran, P. M. O’Byrne; Medicine, McMaster University, Hamilton, ON, CANADA. 687 Low Dose Intranasal Lysine-Aspirin in Patients With AspirinSensitive Nasal Polyps A. A. Parikh1, G. K. Scadding2; 1Dept. of Otolaryngology, St. Mary’s Hospital, London, UNITED KINGDOM, 2Dept. of Rhinology, Royal National Throat, Nose & Ear Hospital, London, UNITED KINGDOM. 688 Impact of Smoking on Scores of Nasal-Specific Quality of Life P. J. Bousquet1, P. Fabbro-Perray2, I. Annesi3, N. Janin4, J. P. Daures2, J. Bousquet1; 1University, CHU, Montpellier, FRANCE, 2University, CHU, Nimes, FRANCE, 3INSERM, Villejuif, FRANCE, 4Pharmapharm, Paris, FRANCE. 689 Comparative Effects of Desloratadine, Fexofenadine and Levocetirizine on Nasal Adenosine Monophosphate Challenge in Patients With Perennial Allergic Rhinitis S. Fujihara, D. K. C. Lee, K. Haggart, M. Gardiner, B. J. Lipworth; Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UNITED KINGDOM. 690 Determinants of Bronchial Hyperresponsiveness (BHR) in Patients With Allergic Rhinitis (AR) N. Mete1, O. Gulbahar1, A. Sin1, M. Erdinc2, F. Sebik1, A. Kokuludag1; 1Internal Medicine, Division of Clinical Immunology and Allergy, Ege University Medical Faculty, Izmir, TURKEY, 2Chest Diseases, Ege University Medical Faculty, Izmir, TURKEY. 691 A Subgroup Analysis in Hispanic Patients With Allergic Rhinitis of Fluticasone Propionate Aqueous Nasal Spray for Sinus Pain and Pressure Caused by Nasal Congestion C. K. Cook, E. E. Philpot, B. A. Prillaman, K. A. Rickard; GlaxoSmithKline, Research Triangle Park, NC. 692 Effects of Surgery to the Function of Maxillary Sinus Mucosa E. M. Toskala1, M. Rautiainen2; 1Otorhinolaryngology, Finnish Institute of Occupational Health, Helsinki, FINLAND, 2Otorhinolaryngology, Tampere University Hospital, Tampere, FINLAND.

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Research and Pharmacological Sciences, CV Therapeutics, Inc., Palo Alto, CA. Association Between Environmental Tobacco Smoke (ETS) and Diminished Dendritic Cell (DC) IL-10 Production During Infancy D. Gentile, J. Howe-Adams, J. Trecki, A. Patel, B. Angelini, D. Skoner; Department of Pediatrics, Allegheny General Hospital, Pittsburgh, PA. Cellular Expressin of Prostaglandin E2 Receptor EP1-4 in Induced Sputum From Atopic Asthmatics: Effect of Allergen Inhalational Challenge Q. Meng, S. Ying, N. L. Woodman, S. Greenaway, K. Mallett, B. O’Connor, T. Lee, C. Corrigan; Department of Asthma, Allergy & Respiratory Medicine, Guy’s, King’s & St Thomas’ Medical School, London, UNITED KINGDOM. Cyclooxygenase-2 Gene Polymorphism G–765C and Prostaglandin Synthesis in Patients With Bronchial Asthma W. Szczeklik, M. Sanak, A. Szczeklik; Department of Medicine, Jagiellonian University School of Medicine, Krakow, POLAND. Importance of Serum IgE for the Improvement in Bronchial Hyperresponsiveness With Inhaled Corticosteroids in Asthmatic Children Y. Park1, Y. Y. Koh2; 1Dept of Pediatrics, Wonkwang University Kunpo Medical Center, Gunpo City, REPUBLIC OF KOREA, 2Dept of Pediatrics, College of Medicine, Seoul National University, Seoul, REPUBLIC OF KOREA. Induction of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) by a Novel Cytokine, IL-17F (ML-1), in Bronchial Epithelial Cells M. Kawaguchi1, F. Kokubu1, M. Odaka1, S. Suzuki1, S. Watanabe1, K. Ieki1, S. Matsukura1, M. Kurokawa1, M. Adachi1, S. Huang2; 11st Department of Internal Medicine, Showa University, Tokyo, JAPAN, 2Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD. Depleting Anti-CD4 Monoclonal Antibody Inhibits the Bronchial Late Phase Response in a Mouse Model of Asthma I. Meyts, P. W. Hellings, P. Cadot, A. Kasran, E. Dilissen, D. Bullens, J. Ceuppens; Laboratory for Experimental Immunology, KU Leuven, Leuven, BELGIUM. Increased Release of Matrix Metalloproteinase-9 and Transforming Growth Factor-β1 in the Plasma of Children With Persistent Asthma H. Chung1, S. Kim2; 1Dept. of Pediatrics, School of Medicine, Catholic University of Taegu, Taegu, REPUBLIC OF KOREA, 2Dept. of Clinical Pathology, School of Medicine, Catholic University of Taegu, Taegu, REPUBLIC OF KOREA. Association of Cytokines IL-13 & RANTES Gene Promoter Polymorphism With Asthma &/or Atopy in African Americans I. A. Moissidis, B. Chinoy, K. Yanamandra, D. Napper, T. F. Thurmon, J. A. Bocchini, Jr., S. L. Bahna; Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, LA. Resolution of Atopic Wheezer Is Associated With Normalization of T-bet Expression and Interferon-γ Response C. Lin; Department of Pediatrics, Children Hospital, Changhua Christian Hospital, Changhua, TAIWAN REPUBLIC OF CHINA. Inhibition of PKC-Alpha Activity Blocks Respiratory Syncytial Virus Infection H. G. San Juan Vergara1,2, R. F. Lockey1,2, S. S. Mohapatra1,2; 1University of South Florida, Tampa, FL, 2VA Hospital, Tampa, FL. Giant Ragweed Pollen Causes an Increase in Bronchial Airway Permeability S. Ramanuja, K. A. Mohammed, R. Van Horn, V. B. Antony; Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University, Indianapolis, IN.

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Nasal Inspiratory Flow After the Cold Pressor Test in Normal Subjects, Non-Allergic Rhinitis and Allergic Rhinitis A. Mongia1,2, A. Wolff1,2, R. Witkowska1, K. Patel1, L. Bielory1; 1UMDNJ-New Jersey Medical School, Newark, NJ, 2VA New Jersey Healthcare Center, East Orange, NJ. Is Acne Associated With Sinusitis? L. Yao1, M. Fazekas-May2, S. Kamboj1, P. Kumar1; 1Allergy & Clinic Immunology, LSUMC, New Orleans, LA, 2Ent, LSUMC, New Orleans, LA. A Comparison of the Increase in Airflow Following Treatment of Seasonal Allergic Rhinitis (SAR) With Desloratadine or Budesonide M. Detineo1, S. Bhatia1, R. M. Naclerio1, F. M. Baroody2; 1Otolaryngology, University of Chicago, Chicago, IL, 2Otolaryngology and Pediatrics, University of Chicago, Chicago, IL. In Patients Taking Fluticasone Propionate/Salmeterol 100/50µg Diskus® for Asthma, Fluticasone Propionate Nasal Spray 200µg QD Is Superior to Montelukast 10mg QD in the Treatment of Allergic Rhinitis in Patients With Coexistent Allergic Rhinitis: Implication for the One Airway Hypothesis H. S. Nelson1, S. Yancey2, K. Waitkus-Edwards2, B. Prillaman2, E. Philpot2, P. Dorinsky2; 1National Jewish Medical and Research Center, Denver, CO, 2GlaxoSmithKline, Research Triangle Park, NC. Clinical Implications of the Desloratadine Slow Metabolizer (DSM) Phenotype Based on Pharmacokinetic (PK) Principles R. A. Blum1, G. Frick2, S. J. Kovacs3, S. Meeves4, G. Georges3, W. Kraft2; 1Buffalo Clinical Research Center, Buffalo, NY, 2Thomas Jefferson University, Philadelphia, PA, 3Aventis Pharma, Bridgewater, NJ, 4Aventis, Bridgewater, NJ. Olopatadine HCl Nasal Spray Is Effective and Safe for the Treatment of Seasonal (Mountain Cedar) Allergic Rhinitis P. H. Ratner1, F. C. Hampel2, N. J. Amar3, J. H. van Bavel4, D. Mohar5, G. M. Wall6, M. Brubaker6, M. Drake6, S. Potts6; 1Sylvana Research, San Antonio, TX, 2Central Texas Health Research, New Braunfels, TX, 3Allergy and Asthma Center, Waco, TX, 4Allergy and Asthma Assoc., Austin, TX, 5Kerrville Allergy and Asthma Associates, PA, Kerrville, TX, 6Alcon Research, Ltd., Fort Worth, TX. Desloratadine Does Not Adversely Impact Subject-Reported Clear-Headedness, Perception of Performance, or Proficiency J. A. Wilken1, C. Sullivan1, R. Kane2; 1Neuropsychology, V.A. Medical Center, Washington, D.C., Rockville, MD, 2Neuropsychology, V.A. Medical Center, Baltimore, Baltimore, MD. Fexofenadine HCl 60 mg/Pseudoephedrine HCl 120 mg Has a Rapid Onset of Action of 45 Minutes in Seasonal Allergic Rhinitis (SAR) Patients R. Berkowitz1, F. McCafferty1, S. Shaver1, C. Lutz1, D. Bazelmans1, P. Godfrey1, S. Meeves2, Y. Liao2, C. Qiu2, G. Georges2; 1Atlanta Allergy & Asthma Clinic, Atlanta, GA, 2Aventis Pharma, Bridgewater, NJ. Inflammation in Nasal Lavage Fluid in Chronic Rhinosinusitis A. Tripathi1, A. M. Ditto1, D. B. Conley2, R. C. Kern2, C. L. Goolsby3, L. C. Grammer1; 1Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL. Measuring the Senses: Patients Do Have Like/Dislike for Various Intranasal Corticosteroid (INS) Product Sensory Attributes C. Leibman, L. O’Dowd, T. Uryniak, J. Levinson; AstraZeneca, Wilmington, DE. A Comparison of Rofleponide Palmitate Nasal Spray (RPNS) With Budesonide Aqueous Nasal Spray (BANS) and Placebo for Seasonal Allergic Rhinitis (AR) Using the Environmental Exposure Unit (EEU)

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J. H. Day1, M. Briscoe1, E. Rafeiro1, C. Schrewelius2, B. Simpson3, L. O’Dowd3; 1Division of Allergy and Immunology, Kingston General Hospital, Kingston, ON, CANADA, 2AstraZeneca R & D, Lund, SWEDEN, 3AstraZeneca LP, Wilmington, DE. Chronic Nonallergic Rhinitis in Children: Role of Adenoidal Hypertrophy M. Rama, E. Yousef, S. J. McGeady; Allergy-Immunology, A.I. duPont Hospital for Children/Thomas Jefferson University, Wilmington, DE. Xenon Chloride Ultraviolet-B Laser Phototherapy in Allergic Rhinitis L. Kemeny1, Z. Csoma1, A. I. Koreck1, F. Ignacz2, Z. Bor2, G. Szabo2, L. Bodai1, A. Dobozy1; 1Department of Dermatology and Allergology, University of Szeged, Szeged, HUNGARY, 2Department of Optics and Quantum Electronics, University of Szeged, Szeged, HUNGARY. Clinical Efficacy of Cysteinyl Leukotriene Receptor Antagonism in Nasal Polyposis: Relationship to Systemic Action on Eosinophils? P. K. Keith1, P. Ferrie1, M. Conway1, A. Dalrymple1, S. Waserman1, M. L. Schmuck2, J. Denburg1; 1Medicine, McMaster University, Hamilton, ON, CANADA, 2Educational Research and Development, McMaster University, Hamilton, ON, CANADA. In Patients Taking Fluticasone Propionate/Salmeterol 100/50µg Diskus® for Asthma, the Addition of Fluticasone Propionate Nasal Spray 200µg QD to Treat Concomitant Allergic Rhinitis Has a Safety Profile Comparable to the Addition of Montelukast 10mg QD or Placebo R. A. Nathan1, E. Philpot2, M. Faris2, B. Prillaman2, S. Yancey2, P. Dorinsky2; 1University of Colorado Health Sciences Center, Denver, CO, 2GlaxoSmithKline, Research Triangle Park, NC. Chronic Sinusitis Subtypes and Airway Function J. N. Baraniuk, K. White; Georgetown University Medical Center, Washington, DC. Immunodeficiency in Subtypes of Chronic Sinusitis K. White, J. N. Baraniuk; Georgetown University Medical Center, Washington, DC.

Poster Session 4403 Monday, March 22 11:00 AM to 12:00 PM Immunogenetics 710 HE2000 Upregulates Expression of the Interferon Gamma Receptor in the L. donovani-Infected U937 Human Macrophage Cell Line W. W. Carr, J. Hershey, M. Nelson; Allergy and Immunology, Walter Reed Army Medical Center, Washington, DC. 711 Overexpression of Leukotriene C4 Synthase (LTC4S) and Plasminogen Activator Inhibitor 1 (PAI-1) Gene Promoter Polymorphisms in Sinusitis J. W. Steinke, E. Barekzi, K. Hise, L. Borish; Asthma & Allergic Diseases Ctr, University of Virginia, Charlottesville, VA. 712 Association Between TBXA2R T924C Polymorphism and Pulmonary Function in Korean Children With Asthma S. Lee1, J. Kim1, B. Kim1, S. Choi2, S. Lee2, S. Hong1; 1Department of Pediatrics, Asan Medical Center, Seoul, REPUBLIC OF KOREA, 2Asan Institute for Life Sciences, Seoul, REPUBLIC OF KOREA. 713 Sequence Variants in the 3’-Untranslated Region of CRTH2 Are Associated With Asthma and Differentially Influence the mRNA Stability P. S. Gao1, R. A. Mathisas2, S. Hsu1, B. Plunkett1, A. Togias1, K. C. Barnes1, C. Stellato1, T. H. Beaty3, S. K. Huang1; 1Division of

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Human Genome Research Institute, National Institutes of Health, Baltimore, MD, 3Pediatric Pneumology and Immunology, Charite-Humboldt University, Berlin, GERMANY, 4Allergy & Clinical Immunology, Johns Hopkins University, Baltimore, MD, 5Pilot Therapeutics, Inc., Charleston, SC.

Poster Session 4404 Monday, March 22 11:00 AM to 12:00 PM Immunoregulation and Modulation 724 Humoral Immune System Role in the Pathogenesis of Vitiligo S. Farrokhi, Sr.; Department of Immunology of Boushehr Medical Sciences, Medical Sciences, Tehran, IRAN (ISLAMIC REPUBLIC OF). 725 Non-specific Elevation of Antistreptolysin Antibody (ASO) in the Absence of Streptococcal Pharyngitis D. S. Theodoropoulos1,2; 1Department of Allergy and Marshfield Medical Research Foundation, Marshfield Clinic, Marshfield, WI, 2Departments of Internal Medicine and Pediatrics, University of Wisconsin, Medical School, Madison, WI. 726 Effect of Neonatal Antigen Exposure on Airways Hyperresponsiveness in a Murine Model of Allergic Rhinitis and Asthma Y. Wang, C. McCusker; Division of Allergy and Immunology, Montreal Children’s Hospital Research Institute and MeakinsChristie Laboratories, McGill University, Montreal, PQ, CANADA. 727 Inhibition of Matrix Metalloproteinase-9 by Doxycycline Reduces Airway Inflammation and Hyperresponsiveness in a Murine Model of Toluene Diisocyanate-Induced Asthma Y. C. Lee, K. S. Lee, S. M. Jin, J. S. Lim, H. L. Jin, H. J. Kim, J. H. You; Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, Jeonju, Chonbuk, REPUBLIC OF KOREA. 728 Mechanisms of Non-IgE Mediated Adverse Reaction to Common Dietary Proteins (DPs) in Children With Autism Spectrum Disorders (ASD) H. Jyonouchi, L. Geng, A. Cushing-Ruby, B. Zimmerman-Bier; Pediatrics, New Jersey Medical School, UMDNJ, Newark, NJ. 729 Selective Modulation of Inflammatory Responses Without Immunosuppression With the Dual α4/β1-α4/β7 Integrin Antagonist R411 In Vivo K. Pendino, J. W. Tilley, L. M. Renzetti; Hoffmann-La Roche Inc, Nutley, NJ. 730 IgA Increases NF-kB in CALU-3 Cells: Implications for Cystic Fibrosis Airway Inflammation K. D. Hauff, J. Yu, J. Richman-Eisenstat; Manitoba Institute of Cell Biology, Depts. of Pharmacology & Therapeutics, Medicine, University of Manitoba, Winnipeg, MB, CANADA. 731 Serum IgE Responses to Alternaria in Th1-Biased Fisher-344 Rats M. M. Montalbano1, H. Sanchez2, R. Bush1; 1University of Wisconsin Department of Medicine, Madison, WI, 2William S Middleton VA Medical Center, Madison, WI. 732 Comparative In Vitro Bioactivity of Cyclosporine on the Proliferation of Cultured Peripheral Blood Mononuclear Cells (PBMC) in Sarcoidosis Patients (SP) and Healthy Controls (HC) P. Buddiga1, R. Witkowska1, A. Garcia2, E. Capitle1, J. Du1, A. Mongia1, L. Bielory1; 1Div. of Allergy/Immunology, UMDNJ-New Jersey Medical School, Newark, NJ, 2UMDNJ-New Jersey Medical School, Newark, NJ. 733 Utilization of Phycobilisomes to Detect Low Density Cell Surface TGF-beta Expression on Regulatory T Cells Y. Cheng, C. Prussin; Laboratory of Allergic Disease, National Institute of Health, Bethesda, MD.

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Allergy and Clinical Immunology, Johns Hopkins School of Medicine, Baltimore, MD, 2Inherited Disease Research Branch, National Institute of Health, Baltimore, MD, 3Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD. A Case Series of Three Patients With Hyper IgD Syndrome Y. Padeh, A. Rubinstein; Albert Einstein College of Medicine, Bronx, NY. Functional Genomics of Asthma: Role of CLCA3 in Goblet Cell Metaplasia (GCM) but not Airway Hyperreactivity (AHR) J. D. Morton1, Y. G. Alevy1, G. Peltz2, M. J. Holtzman1; 1Department of Medicine, Washington University School of Medicine, St. Louis, MO, 2Roche Bioscience, Palo Alto, CA. Identification of a Novel Mutation of C1 Inhibitor Gene in a Chinese Family With Hereditary Angioedema Y. Zhi1, H. Zhang1, S. Huang2; 1Allergy, Peking Union Medical College Hospital, Beijing, CHINA, 2Genetics, Peking Union Medical College, Beijing, CHINA. STAT6 in17SNP1 and in18SNP1 Polymorphisms Are Not Associated With Asthma or Atopy in Chinese Children C. Y. Li1, T. F. Leung1, N. L. S. Tang2, G. W. K. Wong1, Y. M. Sung2, I. H. S. Chan2, C. W. K. Lam2, T. F. Fok1; 1Department of Pediatrics, The Chinese University of Hong Kong, Hong Kong SAR, HONG KONG SPECIAL ADMINISTRATIVE REGION OF CHINA, 2Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, HONG KONG SPECIAL ADMINISTRATIVE REGION OF CHINA. Mice With Mutations of TNFRSF1A May Reveal Insights Into Pathogenesis of TRAPS, a Dominantly Inherited Autoinflammatory Disease H. D. Komarow, J. J. Chae, N. Raben, G. Wood, D. L. Kastner; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD. The Effect of Household and Familial Clustering on Allergic Status in an Indonesian Community With Endemic Filarial Infection S. Wahyuni1, J. J. Houwing-Duistermaat2, S. K. Chai2, E. Sartono2, M. Yazdanbakhsh2; 1Department of Parasitology, Hasanuddin University, Makassar, INDONESIA, 2Department of Parasitology, Leiden University Medical Center, Leiden, NETHERLANDS. Familial Aggregation of Nasal Polyps Among Asthmatics S. W. Haroldson, A. C. Decker, M. N. Blumenthal; University of Minnesota, Minneapolis, MN. Association Between Variants in the Gene Encoding Myosin Light Chain Kinase (MLCK) and Asthma and Atopy M. Munoz1, A. Zambelli-Weiner1, A. Grant2, M. Lorenzo1, E. Ehrlich1, M. Burki3, L. Gao4, S. Ye4, T. H. Beaty2, J. G. Garcia4, K. C. Barnes1,2; 1Allergy & Clinical Immunology, Johns Hopkins University, Baltimore, MD, 2Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 3The Aga Khan University, Karachi, PAKISTAN, 4Pulmonary & Critical Care Medicine, Johns Hopkins University, Baltimore, MD. Variants in the Gene Encoding Acyloxyloacyl Hydroxylase (AOAH) Are Associated With Total IgE (tIgE) D. Baltadzhieva1, T. Berg1, A. Zambelli-Weiner1, R. A. Mathias2, O. Zardkoohi1, M. Brummet1, L. A. Beck1,3, K. Barnes1; 1Allergy & Clinical Immunology, Johns Hopkins University, Baltimore, MD, 2National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, 3Dermatology, Johns Hopkins University, Baltimore, MD. Evidence for a Relationship Between Fatty Acid Levels and Allergic Disease in a Founder Population A. Grant1, R. A. Mathias2, D. Markakis1, R. Nickel3, C. Bickel4, T. H. Beaty1, M. E. Surette5, K. C. Barnes1,4; 1Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD,

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Management of Persistent Rotaviral Diarrhea in Children With Cystic Fibrosis With Enteral Administration of Intravenous Immunoglobulin J. Scott1, D. Boyer2, C. Duggan3, J. Orange1; 1Division of Immunology, Boston Children’s Hospital, Boston, MA, 2Division of Pulmonary Medicine, Boston Children’s Hospital, Boston, MA, 3Division of Gastroenterology, Boston Children’s Hospital, Boston, MA. Correction of the Defect in Glucocorticoid-Induced IL-10 Synthesis in T Cells From Glucocorticoid Resistant Asthmatic Patients C. M. Hawrylowicz; Asthma, Allergy and Respiratory Sciences, King’s College London, London, UNITED KINGDOM. A Novel Role of the Pulmonary Clara Cell Secretory 10 kD Protein (CC10) in the Regulation of T-Cell Responses C. H. Hung1,2, Z. Zhang3, B. Chowdhury3, B. A. Plunkett1, S. K. Huang1; 1Johns Hopkins Asthma & Allergy Center, Baltimore, MD, 2Department of Pediatrics, Ti-Service General Hospital, Taipei, TAIWAN REPUBLIC OF CHINA, 3National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD. Intranasal and Intragastric Allergen Immunotherapy Prevented Chronic Histopathologic Changes in a Murine Model of Asthma O. Yesil, T. Akkoc, D. Yazi, R. Sancak, N. Bahceciler, I. Barlan; Pediatric Allergy and Immunology, Marmara University, Istanbul, TURKEY. The Low Affinity IgE Receptor, CD23, Expressed on Antigen Presenting Cells Alters T-Cell Response to Allergen J. A. Poole, J. Meng, L. Cao, C. Bates, L. J. Rosenwasser; Allergy and Immunology, National Jewish Medical and Research Center, Denver, CO. Intratracheal Administration of Mycobacterium vaccae as a Long Term Effect on Airway Histopathology of Chronic Asthma in BALB/c mice D. Yazi, T. Akkoç, Ö. Ye_il, R. Sancak, Ö. Peker, N. Bahceciler, I. Barlan; Pediatric Allergy and Immunology, Marmara University, Istanbul, TURKEY. Low Dose Intranasal and High Dose Intragastric Allergen Immunotherapy Is Effective in the Treatment of Already Established Chronic Asthma in BALB/c mice T. Akkoc1, O. Yesil1, D. Yazi1, R. Sancak1, O. Peker2, N. Bahceciler1, I. B. Barlan1; 1Marmara University, Istanbul, TURKEY, 2Haydarpasa Numune Hospital, Istanbul, TURKEY. In Vitro Basophil Histamine Release in Response to the Major Alternaria Allergen rAlt a2 E. L. Keyes1, H. Sanchez2, R. K. Bush3; 1Department of Research, William S. Middleton Veterans Memorial Hospital, Madison, WI, 2Research, William S Middleton Veterans Memorial Hospital, Madison, WI, 3Department of Medicine, University of WisconsinMadison/William S. Middleton Veterans Hospital, Madison, WI. The Mitogen-Activated Protein Kinase Extracellular SignalRegulated Kinase 1/2 (ERK1/2) Pathway Is Involved in Superantigen (sAg)-Induced Steroid Resistance of Human T Cells L. Li, E. Goleva, D. Y. M. Leung; Department of Pediatrics, National Jewish Medical & Research Center, Denver, CO. Tolerogenic APC Suppress Both Th1 and Th2 Types of Immune Response-Mediated Pathogenesis in Disease Models J. Zhang-Hoover1,2, P. Finn2, J. Stein-Streilein1,2; 1Immunology, Schepens Eye Research Institute, Boston, MA, 2Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women’s Hospital, Boston, MA. Suppression of Cytokine Response by Anti-Allergic Drugs Y. Aragane1, T. Grzela1,2, T. Yudate1, T. Markova3, S. M. Ashenagar1, A. Kawada1, H. Higashino3, T. Tezuka1; 1Dermatology, Kinki University School of Medicine, Osakasayama-city,

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JAPAN, 2Histology and Embryology, Warsaw Medical University, Warsaw, POLAND, 3Pharmacology, Kinki University School of Medicine, Osakasayama-city, JAPAN. Human Regulatory T-Cell-Lines Cultures Maintained With CD3/CD28 Expander Beads A. Domdey1, A. Liu1, A. Millner1, I. Søndergaard2, P. Adler Würtzen1; 1Biological Research 10313, ALK-Abelló, Hørsholm, DENMARK, 2Institute for BioCentrum, Technical University of Denmark, Lyngby, DENMARK. Development of a Novel Ex Vivo Model of Allergic Immune Responses Using Human Tonsil Tissue O. Hajoui1, H. Zheng1, B. D. Mazer1,2; 1Meakins Christie Laboratories, McGill University, Montreal, PQ, CANADA, 2Montreal Children’s Hospital, Montreal, PQ, CANADA. In Vitro Assessment of Nanoparticle Design for Targeting and Modulating Dendritic Cells (DCs) S. C. Hsu1,2, T. H. Tsai2,3, Y. C. Lee4, S. K. Huang2; 1University of Maryland at College Park, College Park, MD, 2Johns Hopkins Asthma and Allergy Center, Baltimore, MD, 3Municipal Wan Fang Hospital, Taipei, TAIWAN REPUBLIC OF CHINA, 4Department of Biology, Johns Hopkins University, Baltimore, MD. Anti-Fas Antibodies in IVIG Products and in Healthy Blood Donors M. T. Stellamor1, H. P. Schwarz2, H. Ehrlich2, K. Zimmermann2, F. Scheiflinger2, B. M. Reipert2; 1BMT-Research, Vienna, AUSTRIA, 2Baxter AG, Vienna, AUSTRIA. Probiotic Bifidobacteria breve C50 Supernatant Modulate Maturation Surface Markers Expression, Allostimulatory Capacity and IL12 Synthesis in Human Dendritic Cells C. Hoarau; Immunology, Public Hospital, Tours, FRANCE. HPV6 Up-regulates Cyclooxygenase-2 in Recurrent Respiratory Papillomatosis (RRP) D. W. Rosenthal1, J. A. DeVoti1, B. M. Steinberg2, V. R. Bonagura1; 1Allergy/Immunology, Long Island Jewish Medical Center, Schneider Children’s Hospital, New Hyde Park, NY, 2Otolaryngology, Long Island Jewish Medical Center, New Hyde Park, NY. Evaluating the Fc-Function of Intravenous Immunoglobulin Products by Flow Cytometry B. M. Reipert1, J. Ilas1, S. Füreder2, W. Teschner1, H. P. Schwarz1; 1Baxter AG, Vienna, AUSTRIA, 2University of Vienna, Vienna, AUSTRIA. NK Cells Induce Corticosteroid Unresponsiveness in B-Cells Treated With IL-15 Q. Xu, E. Goleva, D. Y. M. Leung; Department of Pediatrics, National Jewish Medical & Research Center, Denver, CO. Combining Long-Acting Beta2-Agonists and Glucocorticoids Induces Greater Inhibition of Allergen-Specific Th2 Cytokine and Enhances IL-10 Responses E. Peek, D. Richards, T. Adikibi, P. Lavender, T. Lee, C. Corrigan, C. Hawrylowicz; Dept of Asthma, Allergy and Respiratory Science, KCL, London, UNITED KINGDOM. Modulation of Intracellular Gene Expression Toward Th2 Predominant Profile by Monosodium Glutamate in Jurkat Cell Line J. Shin1, Y. Seo2, N. Cho3, G. Noh4; 1Pediatric Allergy, Joey Children’s Hospital, Taejeon, REPUBLIC OF KOREA, 2Molecular Immunology, Seoul Allergy Research Institute, Food BioTech Co.Ltd, Seoul, REPUBLIC OF KOREA, 3Microarray & Molecular Immunology, Seoul Allergy Research Institute, Food BioTech Co.Ltd, Seoul, REPUBLIC OF KOREA, 4Allergy & Clinical Immunology, Seoul Allergy Clinic, Seoul, REPUBLIC OF KOREA. The Recombinant Tissue Plasminogen Activator (rTPA) Enhances Il-8 and Matrix Metalalloproteinase 1 Activities B. D. Hill1, U. Nair1, S. Kanangat1, R. Mora2, M. Barbieri2, T. J. Yoo1; 1Allergy/Immunology, University of Tennessee, Memphis, TN, 2Ent, University of Genoa, Italy, Genoa, ITALY.

Abstracts S379

J ALLERGY CLIN IMMUNOL VOLUME 113, NUMBER 2

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Induction of Apoptosis by Sucrose in a Human B Cell Line S. Gollapudi, E. Tsai, K. Su, S. Gupta; Cellular and Molecular Immunology Laboratory, Division of Basic and Clinical Immunology, University of California at Irvine, Irvine, CA. Role of NF-kappaB Signaling Pathway in Increased Apoptosis of Lymphocytes in Aged Humans S. Gupta, L. Yel, C. Kim, S. Chiplunkar, S. Gollapudi; Medicine/Immunology, University of California, Irvine, CA. Osteopontin: A Potential Biomarker for Successful Allergen Immunotherapy S. Konno1, D. B. K. Golden1, J. Schroeder1, J. A. Eckman1, T. P. King2, R. G. Hamilton1, P. S. Creticos1, L. M. Lichtenstein1, S. K. Huang1; 1Johns Hopkins Asthma and Allergy Center, Baltimore, MD, 2Rockefeller University, New York, NY. Interleukin (IL)-4 Antagonism Increases IL-10 Production by Naïve T Lymphocytes: Association With Apoptosis J. Negri, L. Borish; Asthm and Allergic Disease Center, University of Virginia Health Systems, Charlottesville, VA. IgE Enhances Clearance of Trichinella Spiralis and Regulates Mast Cell Responses in Mice M. Gurish1, P. J. Bryce2, H. Tao1, A. B. Kisselgof2, E. M. Thornton3, H. R. Miller3, D. S. Friend1, H. C. Oettgen2; 1Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 2Children’s Hospital, Harvard Medical School, Boston, MA, 3University of Edinburgh, Easter Bush, UNITED KINGDOM. Immunologic and Non-immunologic Association of Posttransplant Diabetes Mellitus (PTDM) a Pilot Study M. I. Mabudian, J. L. Thomson, P. Kumar; Allergy and Immunology, Louisiana State University Health Sciences Center, New Orleans, LA. Elevated IgE Associated With Factor VIII Inhibitor Levels in Patients With Hemophilia A A. N. Salicru, M. Escobar, W. K. Hoots, G. D. Marshall, Jr.; Div. Allergy & Clin Immunology, Univ TX-Houston Medical School, Houston, TX. The Influence of Transplant Nephrectomy on Panel Reactive Antibodies (PRA) Directed Against HLA Antigens – A Pilot Report R. Ramachandran1, P. Kumar1, B. Arora1, K. Wiley1, T. Ramcharan2; 1Allergy & Immunology, Loiusiana State University Medical Center, New Orleans, LA, 2Surgery, Loiusiana State University Medical Center, New Orleans, LA. Positional Effect of Amino Acid Replacement on Peptide Antigens for the Enhancement of IFNg Production T. Liu1, H. Kohsaka2, Y. Uemura1, H. Ohyama1, S. Matsushita1; 1Allergy and Immunology, Saitama Medical School, Moroyama, JAPAN, 2Tokyo Meidical and Dental University, Moroyama, JAPAN.

Poster Session 4405 Monday, March 22 11:00 AM to 12:00 PM Therapeutic Advances in Dermatologic and Ocular Diseases 765 Tacrolimus, a New Treatment to Atopic Dermatitis: An Observational Pilot Study under Routine Clinical Practice Conditions D. Gonzalez de Olano; Allergy, Hospital Ramón y Cajal, Madrid, SPAIN. 766 Patient Evaluation of Azelastine Ophthalmic Solution in Allergic Conjunctivitis C. J. Siegel1, L. J. Kanter2; 1University of Missouri, Kansas City, MO, 2University of California School of Medicine, San Francisco, CA. 767 Relative Efficacy of Butterbur and Mediator Antagonists on the Histamine and Allergen Cutaneous Response

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P. C. Soutar, D. K. C. Lee, C. M. Jackson, B. J. Lipworth; Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UNITED KINGDOM. The Use of Intravenous Immunoglobulin in Stevens-Johnson Syndrome V. C. Gowda, W. B. Klaustermeyer; Division of Allergy & Immunology, Department of Medicine, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA. Vernal Keratoconjunctivitis: Fifteen Months Experience With 0.1% Topical Ophthalmic FK-506 Ointment W. Durongpisitkul; Department of Pediatrics, Siriraj Hospital, Mahidol university, Bangkok, THAILAND.

Poster Session 4406 Monday, March 22 11:00 AM to 12:00 PM Novel Treatment of Asthma 770 Safety, Tolerability, and Pharmacokinetics of R411, a Dual α4/β1–α4/β7 Integrin Antagonist, After Oral Administration of Single-Ascending Doses in Healthy Male Subjects R. Abbas1, Y. Hijazi2, L. M. Renzetti1, J. P. Tang1, A. Rames2, H. Welker2; 1Hoffmann-La Roche Inc, Nutley, NJ, 2F. Hoffmann-La Roche, Basel, SWITZERLAND. 771 Ku-Shen (Sophora flavescens Ait), a Single Chinese Herb, Abrogates Airway Hyperreactivity in a Murine Model of Asthma M. C. Wen1, C. K. Huang1, K. D. Srivastava1, T. F. Zhang1, B. Schofield2, H. A. Sampson1, X. M. Li1; 1Mount Sinai School of Medicine, New York, NY, 2Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD. 772 Reversal of Allergic Airway Inflammation and Airway Hyperresponsiveness by Second-Generation Immunomodulatory Oligonucleotide Agents Containing Novel RpG Motifs D. K. Agrawal1, J. Edwan1, E. R. Kandimalla2, D. Yu2, S. Agrawal2; 1Internal Medicine/Allergy, Creighton University School of Medicine, Omaha, NE, 2Hybridon, Inc., Cambridge, MA. 773 Inhibition of Pulmonary Inflammation by Roflumilast: Effects on the Time Course of Cell Infiltration, Total Protein Accumulation, and Mediator Release in OVA-Challenged Brown Norway Rats R. Beume, A. Ostermann, J. Barsig, D. Marx, A. Wohlsen, L. Wollin, D. Bundschuh; Pharmacology Inflammation, ALTANA Pharma AG, Konstanz, GERMANY. 774 HYB 2055 – A Second-Generation Immunomodulatory Oligonucleotide Containing CpR Motifs Potently Reverses Allergic Airway Inflammation and Airway Hyperresponsiveness in Mouse Models of Established Asthma E. R. Kandimalla1, J. Edwin2, D. Yu1, F. Zhu1, S. Agrawal1, D. K. Agrawal2; 1Hybridon, Inc., Cambridge, MA, 2Internal Medicine/Allergy, Creighton University School of Medicine, Omaha, NE. 775 IPD-1151T (Suplatast Tosilate), an Anti-Allergic Agent, Inhibits Platelet-Activating Factor (PAF)-Induced b2 Integrin Expression on the Eosinophilic Cell Line (EoL-l) K. Hamada, N. Saito, S. Ueki, K. Yamaguchi, A. Kanda, T. Chiba, H. Kayaba, J. Chihara; Department of Clinical and Laboratory Medicine, Akita University School of Medicine, Akita, JAPAN. 776 Anti-Inflammatory Effects of LY294002, a PI3K Inhibitor, in a Mouse Model of Asthma W. Duan1, H. Chan1, C. Vlahos2, W. Wong1; 1Pharmacology, National University of Singapore, Singapore, SINGAPORE, 2Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN. 777 Therapeutic Effects of the Chinese Herbal Formula, MSSM003d, on Persistent Airway Hyperreactivity and Airway Remodeling

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P. J. Busse1, M. C. Wen1, C. K. Huang1, K. D. Srivastava1, T. F. Zhang1, B. Schofield2, H. A. Sampson1, X. M. Li1; 1Pediatrics, Mount Sinai School of Medicine, New York, NY, 2Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD. The Effect of Secretory Leukocyte Proteinase Inhibitor (SLPI) in a Murine Model of Asthma S. D. Nandedkar1, K. S. Konduri1, N. Duzgunes2, D. A. Rickaby3, J. D. Henderson4; 1Pediatrics, Medical College Of Wisconsin, Milwaukee, WI, 2Microbiology, University of the Pacific School of Dentistry, San Francisco, CA, 3Physiology, Zablocki VA Medical Center, Milwaukee, WI, 4Surgery, Zablocki VA Medical Center, Milwaukee, WI. Inhibition of Pulmonary Inflammatory Diseases, Asthma and Pulmonary Fibrosis, by Lipoxin A4 and a Novel Series of Selective Small Molecule FPRL1 Agonists C. Wang, F. Rosas, M. Ramirez, V. Nioko, A. Verdu, P. Dosa, S. Tamura, G. Kelner; Inflammation, Arena Pharmaceuticals, San Diego, CA. Roflumilast, a Novel, Oral, Selective PDE4 Inhibitor, Shows High Absolute Bioavailability M. David1, K. Zech1, M. Seiberling2, C. Weimar1, T. D. Bethke1; 1ALTANA Pharma AG, Konstanz, GERMANY, 2Swiss Pharma Contract Ltd., Allschwil, SWITZERLAND. Mechanism of Bronchoprotective Effects of a Novel Natriuretic Horomone Peptide G. Hellerman1,2, J. Gunnarsdottir1, X. Kong1,2, H. San Juan1,2, R. Singam1,2, S. Behera1, W. Zhang1,2, R. F. Lockey1,2, S. S. Mohapatra1,2; 1Dept. of Internal Medicine, Div. of Allergy and Immunology, University of South Florida, Tampa, FL, 2VA Hospital, Tampa, FL. Dual α4/β1–α4/β7 vs α4/β1 Selective Antagonism Is Required for Attenuation of Allergic Inflammatory Responses L. M. Renzetti, L. Chen, N. Tare, S. Tannu, A. Sidduri, G. Cavallo, J. W. Tilley; Hoffmann-La Roche Inc, Nutley, NJ. Anti-4-1BB Agonistic Antibody Abolishes Allergen-Specific IgE But Does Not Reduce Airway Hyperreactivity and Eosinophilic Inflammation in a Murine Model of Asthma Y. Cho1, B. Kwon2, J. Lee1, Y. Oh3, B. Yoo1, H. Moon1; 1Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, REPUBLIC OF KOREA, 2Immunomodulation Research Center, University of Ulsan, Ulsan, REPUBLIC OF KOREA, 3Respiratory and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, REPUBLIC OF KOREA. Pharmacokinetics and Safety of Roflumilast, a Once-Daily, Oral, Selective PDE4 Inhibitor, and Its Active Metabolite Roflumilast N-oxide in Healthy Subjects A. Huennemeyer1, B. Hauns1, M. David1, G. Böhmer2, R. Fux2, C. H. Gleiter2, J. Waitzinger3, K. Zech1, T. D. Bethke1; 1ALTANA Pharma AG, Konstanz, GERMANY, 2Clinical Pharmacology Department, University Hospital Tuebingen, Tuebingen, GERMANY, 3AAI Applied Analytical Industries Deutschland GmbH, Neu-Ulm, GERMANY. Inhibition of Late Asthmatic Reaction in Allergic Asthma by the Novel, Selective PDE4 Inhibitor Roflumilast E. M. van Schalkwyk1, H. Nell1, K. van Heerden1, L. Venter2, S. Leichtl3, D. Bredenbroeker3, T. D. Bethke3, W. Wurst3, P. G. Bardin4; 1Respiratory Research Unit, Department of Internal Medicine, Stellenbosch University, Tygerberg, SOUTH AFRICA, 2ALTANA Madaus (Pty.) Ltd., Rivonia, SOUTH AFRICA, 3ALTANA Pharma AG, Konstanz, GERMANY, 4Department of Respiratory Medicine, Monash Medical Center and University of Melbourne, Melbourne, AUSTRALIA. Pharmacokinetics of the Selective PDE4 Inhibitor Roflumilast and Its Active Metabolite Roflumilast N-oxide Are Not Affected by Concomitant Budesonide, Salbutamol, or Erythromycin B. Hauns1, A. Huennemeyer1, W. Siegmund2, J. Waitzinger3, R.

J ALLERGY CLIN IMMUNOL FEBRUARY 2004

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Hermann1, K. Zech1, T. D. Bethke1; 1ALTANA Pharma AG, Konstanz, GERMANY, 2Institute of Pharmacology, University of Greifswald, Greifswald, GERMANY, 3AAI Applied Analytical Industries Deutschland GmbH, Neu-Ulm, GERMANY. Oral Recombinant Human Lactoferrin (RhLF) in a Nonhuman Primate Model of Asthma M. Van Scott1, P. Glynn2, A. Varadhachary2; 1East Carolina University, Greenville, NC, 2Agennix Inc., Houston, TX. Alteration of Airway Hyperresponsiveness and Expression of MMP-9 and TIMP-1 in Bronchial Tissue by Nebulized IFN-γ in Murine Model of Asthma Y. Lee, Y. Kim, S. Jon, K. Kim, D. Kim, S. Uh, Y. Kim, C. Park; Allergy & Respiratory Medicine, Soonchunhyang University, School of Medicine, Seoul, REPUBLIC OF KOREA.

Poster Session 4407 Monday, March 22 11:00 AM to 12:00 PM Allergen Characterization 789 Exposure Potential of Other Common Penicillium Species in Indoor Environments P. Fallah, H. A. Burge, J. M. Gallup; Environmental Microbiology Laboratory, San Diego, CA. 790 Influence of Geographic Origin, Age and Gender in the Mono or Polisensitization to Pollens in the Southwest of Madrid Region (Spain) M. A. Tejedor, A. Rosado, C. Vila, M. Alonso, M. FernándezRivas, E. González-Mancebo; Unidad de Alergia, Fundacion Hospital Alcorcon, Alcorcon, SPAIN. 791 Aerobiology and Allergenicity of Mesquite Pollen in Chennai, India S. Bhuvaneswari1, B. Vittal1, N. Udaya Prakash2, T. Janaki2, V. Raju2; 1Centre for Advanced Studies in Botany, University of Madras, Chennai 600025, INDIA, 2Asthma and Allergy Research Institute, Raju Hospitals, T. Nagar, Chennai 600017, INDIA. 792 The Presence of Specific IgE to Formaldehyde in Patients With Suspicion of Hypersensitivity to This Agent A. Dymek, L. Dymek, A. Boz˙ ek; Centrum Medyczne LA Dymek, Strzelce Opolskie, POLAND. 793 Performance of a Silent Electrostatic Air Cleaner for Eliminating Culturable Aerosols H. A. Burge1, G. Ko2; 1Eer, Harvard School of Public Health, Boston, MA, 2University of Texas at Houston, Houston, TX. 794 New Pets: New Allergenic Sources M. San Miguel-Moncín1, R. Tella1, C. Río2, F. Pineda2, R. Alonso1, E. Enrique1, J. Bartra1, B. Fernández-Parra1, A. Cisteró-Bahima1; 1Allergy Department, Institut Universitari Dexeus, UAB, Barcelona, Barcelona, SPAIN, 2I+d, DIATER Laboratories, Madrid, SPAIN. 795 Allergic Contact Urticaria Caused by a Chameleon in a Patient Sensitized to Ficus benjamina R. Jarisch, G. Sesztak-Greinecker, M. Götz, W. Hemmer; Floridsdorf Allergy Center, Vienna, AUSTRIA. 796 Skin Prick Test Reactivity to Dust Mites, Cockroach and Molds Correlates With Reactivity to Distinct Sets of Environmental Allergens S. N. Hassan1, F. El-Zeky2, J. A. Grant1, S. Sur1; 1Allergy and Immunology, UTMB, Galveston, TX, 2Office of Biostatistics, UTMB, Galveston, TX. 797 The Latex Allergen Hev b 5 Is a Multivalent Antigen D. H. Beezhold1, V. L. Hickey2, M. F. Sutherland3, R. E. O’Hehir3; 1NIOSH, Morgantown, WV, 2Guthrie Research Institute, Sayre, PA, 3Alfred Hospital/Monash University, Melbourne, AUSTRALIA.

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Isolation and Characterization of a Novel Major Dermatophagoides pteronyssinus Mite Allergen, Der p 11 L. C. Tsai1, P. L. Chao1, R. B. Tang2, M. W. Hung1, H. D. Shen1, S. H. Han1; 1Department of Medical and Education, Paipei-Veterans General Hospital, Taipei, TAIWAN REPUBLIC OF CHINA, 2Deprtment of Pediatrics, Paipei-Veterans General Hospital, Taipei, TAIWAN REPUBLIC OF CHINA. Isolation and Characterization of the Early Nodule Specific Protein Homologue (Hev b 13), an Allergenic Lipolytic Esterase From Hevea brasiliensis Latex S. A. M. Arif1, R. G. Hamilton2, F. Yusof1, N. P. Chew1, Y. H. Loke1, S. Nimkar3, J. J. Beintema4, H. Y. Yeang1; 1Biotechnology and Strategic Research, Rubber Research Institute of Malaysia, Sungei Buloh, MALAYSIA, 2School of Medicine, John Hopkins University, Baltimore, MD, 3Applied Biosystems, Foster City, CA, 4Department of Chemistry, University of Groningen, Groningen, NETHERLANDS. Molecular, Proteomic and Immunological Characterization of Isoforms of Arginine Kinase, a Cross-Reactive Invertebrate PanAllergen, From the House Dust Mite, Dermatophagoides farinae X. Z. Bi1, F. T. Chew2; 1Department of Biological Sciences, National University of Singapore, Singapore, SINGAPORE, 2Dept. of Biological Sciences, National University of Singapore, Singapore, SINGAPORE. IgE Profiles in Dutch Hazelnut Allergic Patients: Non-pollen Related Recognition of Cor a 1 and Pepsin-induced Neo-epitopes J. H. Akkerdaas1, M. Wensing2, A. van Leeuwen1, P. Schilte3, S. L. Hefle4, R. C. Aalberse1, R. van Ree1; 1Immunopathology, Sanquin, Amsterdam, NETHERLANDS, 2Dermatology/Allergology, UMCU, Utrecht, NETHERLANDS, 3Pediatric Pulmonary Disease, MCA, Alkmaar, NETHERLANDS, 4Food Allergy Research and Resource Program, University of Nebraska, Lincoln, NE. Classification of 190 Allergens by Cluster Analysis Based on the IgE Binding Profiles of 483 Consecutive Food Allergic Individuals Using an Immuno-Microarray Assay X. S. Wang1, T. C. Ong1, D. Y. Wang2, F. T. Chew3; 1Paediatrics, National University of Singapore, Singapore, SINGAPORE, 2Otolaryngology, National University of Singapore, Singapore, SINGAPORE, 3Biological Sciences, National University of Singapore, Singapore, SINGAPORE. Identification of Raw and Cooked Snow Crab Proteins That Elicit IgE Reactivity in Snow Crab Processing Workers P. Venkatesh1, A. Cartier2, L. Horth-Susin3, M. Jong4, M. Swanson5, D. Currie1, B. V. Gill1, G. Reese6, B. Neis7, S. B. Lehrer1; 1Allergy, Clinical Immunology, and Rheumatology, Tulane University Health Sciences Center, New Orleans, LA, 2H. du SacreCoeur de Montreal, Montreal, PQ, CANADA, 3Valley Regional Hospital, Kentville, NS, CANADA, 4Health Labrador Corporation, Goose Bay, PQ, CANADA, 5Mayo Clinic, Rochester, MN, 6PaulErlich-Institut, Langen, GERMANY, 7Safety Net, Memorial Hospital, St-Johns, NF, CANADA. Isolation and Characterization of a cDNA Clone Encoding One IgE-Binding Fragment of Penicillium brevicompactum S. Sevinc, V. Kumar, M. Abebe, H. M. Vijay; Environmental Health, Health Canada, Ottawa, ON, CANADA. Biochemical Characterization of Recombinant Phl p 6 and Comparison With Natural Phl p 6 and Recombinant Phl p 5 R. B. Støvhase, K. Meno, M. Olsen, L. Friberg, T. Lenhard; Biochemical Research, ALK-Abello, Hørsholm, DENMARK. Ligand Binding: An Intrinsic Property of Cockroach Allergen Bla g 2? S. Wuenschmann1, M. Li2, A. Gustchina2, M. D. Chapman1, A. Pomes1; 1INDOOR Biotechnologies, Inc., Charlottesville, VA, 2Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD.

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Generation of Mono-specific Recombinant Antibody Fragments From Chicken to Allergenic Proteins Fel d 1, Amb a 1 and Whole Yellow Jacket Venom W. J. J. Finlay, E. N. Dobrovolskaia, A. Gam, J. E. Slater; Laboratory of Immunobiochemistry, CBER/FDA, Bethesda, MD. Prevalence of Sensitization to Mugwort Pollen Allergens and Association With Food Allergy to Peach F. Polo1, F. J. García-Sellés2, G. García-Casado3, M. Lombardero1, M. J. Chamorro1, R. Sánchez-Monge3, G. Salcedo3, D. Barber1; 1ALK-Abelló, S.A., Madrid, SPAIN, 2Hospital Virgen de la Arrixaca, Murcia, SPAIN, 3E.T.S. Ingenieros Agrónomos, Madrid, SPAIN. Alternaria alternata Mannitol Dehydrogenase, a Fungal Allergen P. B. Schneider1, U. Denk1, C. Ebner2, M. Breitenbach1, B. Simon-Nobbe1; 1Department of Genetics and General Biology, University of Salzburg, Salzburg, AUSTRIA, 2Department of Pathophysiology, University of Vienna, Vienna, AUSTRIA. Identification of Paralogous Forms of the Dust Mite Group 13 Fatty Acid Binding Proteins From Dermatophagoides farinae and Blomia tropicalis: Under-Recognition of Group 13 Allergens as an Important Dust Mite Allergen S. T. Ong1, R. G. Mohd1, B. L. Lua1, W. L. Wang1, K. T. Kuay1, V. Mahakittikun2, K. G. Baratawidjaja3, S. H. Lim4, A. Mari5, L. C. Tsai6, F. T. Chew1; 1Biological Sciences, National University of Singapore, Singapore, SINGAPORE, 2Mahidol University, Thailand, THAILAND, 3University of Indonesia, Indonesia, INDONESIA, 4Malaysian University for Science and Technology, Malaysia, MALAYSIA, 5Allergy Unit, Rome, ITALY, 6Veteran’s General Hospital, Taiwan, TAIWAN REPUBLIC OF CHINA. Cross Comparison of the IgE Binding Profiles to Recombinant Allergens From Suidasia medanensis, Blomia tropicalis and Dermatophagoides farinae Using Sera From Blomia- and Dermatophagoides-Predominant Environments K. Reginald1, Y. F. Gao1, Y. S. Sew2, H. S. Shang1, F. T. Chew1; 1Biological Sciences, National University of Singapore, Singapore, SINGAPORE, 2Food Science and Biotechnology, Universiti Putra Malaysia, Selangor, MALAYSIA. Endotoxin Exposure and Eczema in the First Year of Life W. Phipatanakul1, J. C. Celedon2, B. A. Raby2, A. A. Litonjua2, D. K. Milton3, D. Sredl2, S. T. Weiss2, D. R. Gold2; 1Immunology and Allergy, Children’s Hospital, Boston, Harvard Medical School, Boston, MA, 2Medicine and Respiratory Epidemiology, Channing Laboratory, Brigham and Women’s Hospital, Boston, MA, 3Environmental Health, Harvard School of Public Health, Boston, MA. Dog Allergen (Can f 1) and Cat Allergen (Fel d 1) in U.S. Homes J. Mehta1, S. J. Arbes, Jr.1, M. Yin2, R. Cohn2, D. C. Zeldin1; 1NIEHS, Research Triangle Park, NC, 2Constella Group, Inc., Durham, NC. Effects of Temperature on the Hatchability of Mite Eggs and Their Allergen Concentration J. J. Boitano1, V. Mahakittikun2, C. Komolttri3, H. Nochot2, G. R. Needham4; 1Mahidol University, Stratford, CT, 2Parasitology, Mahidol University, Bangkok, THAILAND, 3Mahidol University, Bangkok, THAILAND, 4Acarology, Ohio State University, Columbus, OH.

Poster Session 4408 Monday, March 22 11:00 AM to 12:00 PM Disease Effects of Aerosolized Particulates, Allergens and Endotoxin 815 Do Airborne Particle and Allergen Exposures in Inner City Homes of Asthmatic Children Differ From Exposures in Suburban Homes of Asthmatic Children?

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Abstracts S381

J ALLERGY CLIN IMMUNOL VOLUME 113, NUMBER 2

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E. Simons1, D. Bunce1, J. Curtin-Brosnan1, K. Callahan1, R. A. Wood1, C. Rand1, S. Kanchanaraksa2, L. Swartz1, N. Durkin1, P. Eggleston1; 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins School of Public Health, Baltimore, MD. Prevalence of Indoor/Outdoor Flying Insect Allergy in a Rural Population T. S. Smith1, N. W. Wilson2, J. E. Welch3, W. T. Corder2, M. B. Hogan2; 1Medicine, West Virginia University School of Medicine, Morgantown, WV, 2Pediatrics, West Virginia University School of Medicine, Morgantown, WV, 3Medicine/Pediatrics, West Virginia University School of Medicine, Morgantown, WV. The Application of Immune Complex Immunization for the Production of Monoclonal Antibodies Against Spores of Penicillium brevicompactum D. Schmechel, J. P. Simpson, D. M. Lewis; Health Effects Laboratory Division, CDC/Natl. Inst. Occup. Safety & Health, Morgantown, WV. Animal House Exposure to Endotoxin and Rodent Allergens J. A. Platts-Mills1, N. Custis1, A. Kenney1, M. D. Chapman2, A. Tsay2, T. A. E. Platts-Mills1; 1University of Virginia, Charlottesville, VA, 2Indoor Biotechnologies, Inc., Charlottesville, VA. Comprehensive Risk Assessments of Home Environments of Low-Income, Non-Inner City Preschool-Aged Children With Asthma C. A. Sorkness, A. G. Staresinic, V. A. Schend, P. M. Hatfield, B. Goodman; School of Pharmacy, University of Wisconsin, Madison, WI. Industrial Processing of Raw Crab Is Associated With Less Allergen Aerosolization M. Swanson1, B. Pelley2, B. Neis2, S. B. Lehrer3, P. Chrétien4, A. Cartrier5; 1Mayo Clinic, Rochester, MN, 2Memorial University, StJohn’s, NF, CANADA, 3Tulane University Health Sciences Center, New Orleans, LA, 4CLSC Sept-Iles, Sept-Iles, PQ, CANADA, 5H. du Sacré-Coeur de Montréal, Montréal, PQ, CANADA. Recovery and Identification of Fungal Spores From the Nasal Cavity J. K. Sercombe1, B. J. Green2, E. R. Tovey1; 1Woolcock Institute of Medical Research, Sydney, AUSTRALIA, 2University of Sydney, Sydney, AUSTRALIA. The Impact of Bedding Encasing on Nocturnal Der p1 Exposure and Asthma C. Marriott, T. J. O’Meara, C. Salome, E. R. Tovey; Woolcock Institute of Medical Research, Camperdown, AUSTRALIA. Trend for Asthma Severity To Be Associated With Total Aeroallergen Exposure E. R. Tovey1, A. J. P. van Overveld2, T. J. O’Meara1, G. B. Marks1; 1Woolcock Institute of Medical Research, Sydney, AUSTRALIA, 2Faculty of Health Sciences, Maastricht, NETHERLANDS. Storage Mite Sensitization in the General Population L. G. Arlian1, A. Yadav1, P. Kondreddi1, B. L. Elder2, M. S. Morgan1; 1Department of Biological Sciences, Wright State University, Dayton, OH, 2CompuNet Clinical Laboratories, Dayton, OH. Health Effects of Ultraviolet Irradiation in Asthmatic Children’s Homes R. C. Bobbitt, Jr.1, M. Glazman2, R. Floyd1, L. Levin3, M. S. Crandall4, P. Prathy1, J. A. Bernstein1; 1Internal Medicine, University of Cincinnati, Cincinnati, OH, 2General Innovations and Goods, Inc., Cincinnati, OH, 3Environmental Health, University of Cincinnati, Cincinnati, OH, 4Indoor Environmental Services, Inc., Cincinnati, OH. Pollen Aeroallergen Sensitization and Efficacy of Fexofenadine in Children From the Southern Hemisphere P. C. Potter1, M. Lisanti2, M. Groenewald3, R. Portes4, E. Weinberg5, P. Vucovich6, A. Puterman7, C. Baena-Cagnani8, P. Hardy9, E. Ruuth9; 1Allergology Unit, University of Cape Town, Cape

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Town, SOUTH AFRICA, 2Instituto de Alergia e Immunologia, Mendoza, ARGENTINA, 3Military Hospital, Pretoria, SOUTH AFRICA, 4Centro de asma, Buenos Aires, ARGENTINA, 5Red Cross Children’s Hospital, Rondebosch, SOUTH AFRICA, 6Hospital Italiano, Córdoba, ARGENTINA, 7Kinsbury Hospital, Cape Town, SOUTH AFRICA, 8Hospital Infantil de Córdoba, Córdoba, ARGENTINA, 9Aventis Pharma, Paris, FRANCE. Identification of High Concentrations of an Allergenic Yeast in the Pasadena Aerosol P. E. Taylor1, M. M. Glovsky2, R. Esch3, R. C. Flagan1; 1Chemistry and Chemical Engineering, Caltech, Pasadena, CA, 2Asthma and Allergy Center, Huntington Medical Research Institute, Pasadena, CA, 3Greer Laboratories, Lenoir, NC. Fexofenadine Effectively Relieves Seasonal Allergic Rhinitis in Children From the USA D. Bernstein1, E. O. Meltzer2, J. van Bavel3, R. Menendez4, H. Milgrom5, A. F. Finn, Jr.6, J. A. Winder7, A. Economides8, P. Hardy9, E. Ruuth9; 1Division of Immunology Allergy, University of Cincinnati, Cincinnati, OH, 2Allergy and Asthma Medical Group and Research Center, San Diego, CA, 3Allergy and Asthma Associates, Austin, TX, 4Allergy and Asthma Research Centre of El Paso, El Paso, TX, 5National Jewish Medical & Research Centre, Denver, CO, 6National Allergy, Asthma and Urticaria Centers, Charleston, SC, 7Toledo Center for Clinical Research, Sylvania, OH, 8Institute for Asthma and Allergy, Chevy Chase, MD, 9Aventis Pharma, Paris, FRANCE. Sensitization to Aeropollinic Allergens in Children From Europe A. Emeryk1, U. Behre2, P. Sipilä3, T. Hofman4, K. Buczylko5, P. Hardy6, E. Ruuth6; 1Dept of Lung Diseases and Rheumatology, University of Medicine in Lublin, Lublin, POLAND, 2Haupstrasse 240, Kehl, GERMANY, 3Porus Medical Center, Oulu, FINLAND, 4Centrum Allergologii, Poznan, POLAND, 5Centrum Allergologii, Lodz, POLAND, 6Aventis Pharma, Paris, FRANCE.

Poster Session 4409 Monday, March 22 11:00 AM to 11:00 PM Food Allergens 830 An Animal Model for Shrimp Allergy: The Influence of Genetic Background and Adjuvant on the Allergen-Specific IgE Response G. Reese1, S. Schicktanz1, S. Randow1, S. B. Lehrer2, S. Vieths1; 1Allergology, Paul-Ehrlich-Institut, Langen, GERMANY, 2Medicine, Tulane University School of Medicine, New Orleans, LA. 831 Chestnut as a Food Allergen: Identification of the Major Allergens and Effect of Gastric and Intestinal Fluids S. Lee; Allergy and Respiratory, Dong-A University, Busan, REPUBLIC OF KOREA. 832 Murine IgE and IgG Antibody Responses to Allergenic and Non-allergenic Foods: Potential Model for Allergenicity Assessment of Foods in Man P. A. Gaudry1, J. Fernandes1, R. Reish1, K. H. Roux2, S. K. Sathe3, S. S. Teuber4, G. Reese5, S. B. Lehrer1; 1Department of Medicine- Section of Clinical Immunology, Allergy, and Rheumatology, Tulane University Health Sciences Center, New Orleans, LA, 2Department of Biological Science, Florida State University, Tallahassee, FL, 3Department of Nutrition, Food & Exercise Science, Florida State University, Tallahassee, FL, 4Division of Rheumatology, Allergy & Clinical Immunology, University of California, Davis, School of Medicine, Davis, CA, 5Department of Allergology, Paul-Ehrlich-Institut, Langen, GERMANY. 833 IgE and IgG Antibody Response to Natural and Recombinant Pen a 1 Measured by ELISA and Mediator Release Assay

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L. J. Ree-Kim1, P. Gaudry1, G. Reese2, S. B. Lehrer1; 1Allergy/Immunology, Tulane Health Sciences Center, New Orleans, LA, 2Allergology, Paul-Ehrlich-Institut, Langen, GERMANY. Genetic Attachment of Undecane Peptides to Ovomucoid Third Domain Can Suppress the Production of Specific IgG and IgE Antibodies Y. Mine, P. Rupa; Food Science, University of Guelph, Guelph, ON, CANADA. The Role of CTLA-4 and a Mucosal Adjuvant Cholera Toxin in Oral Sensitization to Peanut F. van Wijk1, S. Hoeks1, L. Knippels2, L. Boon3, S. Koppelman4, R. Pieters1; 1Immunotoxicology, Institute for Risk Assessment Sciences, Utrecht, NETHERLANDS, 2Experimental Immunology, TNO Nutrition and Food Research, Zeist, NETHERLANDS, 3Bioceros B.V., Amsterdam, NETHERLANDS, 4Protein Technology, TNO Nutrition and Food Research, Zeist, NETHERLANDS. Mites in the Mix: Dust Mite Contamination of a Flour Product D. G. DeMerell, C. E. Olmos, J. M. El-Dahr; Clinical Immunology and Allergy, Tulane University Health Sciences Center, New Orleans, LA. Presence of Common Food Allergens in Commercially Available Pediatric Skin Care Products K. K. Newhall1, L. S. Amoruso2, J. M. Sinacore2, J. A. Pongracic1; 1Pediatrics, Children’s Memorial Hospital, Chicago, IL, 2The Mary Ann & J. Milburn Smith Child Health Research Program, Children’s Memorial Hospital, Chicago, IL. Allergic Reactions to Jackfruit in Birch Pollen Allergic Patients S. T. H. Bolhaar1, R. van Ree2, A. C. Knulst1, L. Zuidmeer2; 1Dermatology and Allergology, University Medical Centre Utrecht, Utrecht, NETHERLANDS, 2Immunopathology, Sanquin Research Foundation, Amsterdam, NETHERLANDS. Routes of Sensitization in Peanut Allergy A. T. Fox, G. Lack; Paediatric Allergy, St Mary’s Hospital, London, UNITED KINGDOM. Ana o 3, an Important Cashew Nut Allergen of the 2S Albumin Family J. M. Robotham1, F. Wang1, V. M. Vest1, S. S. Teuber2, S. K. Sathe1, K. Beyer3, K. H. Roux1; 1Florida State University, Tallahassee, FL, 2Department of Internal Medicine, University of California, Davis, FL, 3University Hospital Charite, Berlin, GERMANY. Antigenecity of Domestic Soy Bean Species and Comparison of Reactivity With Serum Specific IgE S. Park; Pediatrics, Samsung Medical Center, Seoul, REPUBLIC OF KOREA. Effect of Breast Milk Feeding From Allergic and Non-Allergic Mothers on Allergic Induced Cytokine Production W. Kim1, H. Yoon2; 1Pediartics, Seoul Paik Hospital Inje University, Seoul, REPUBLIC OF KOREA, 2Pediatrics, Kangnam Sacred Heart Hospital Hallym University, Seoul, REPUBLIC OF KOREA. Molecular Cloning and Characterization of Persian Melon Major Allergen (cuc m2) A. R. Varasteh1, M. Sankian1, M. Mahmoudi2; 1bu-ali researsh institute, Immunology research center, Mashad, IRAN (ISLAMIC REPUBLIC OF), 2Molecular biology, bu-ali researsh institute, Immunology research center, Mashad, IRAN (ISLAMIC REPUBLIC OF). Development of Rapid and Simple Diagnostic Kits for Food Allergens by Immunochromatography Y. Takahata1, K. Kamiya1, T. Mastumoto1, T. Sato2, R. Shibata3, F. Morimatsu1; 1Nippon Meat Packers, Inc., Ibaraki, JAPAN, 2Nippon Becton Dickinson Company, Ltd., Tokyo, JAPAN, 3National Minami-Fukuoka Hospital, Fukuoka, JAPAN. Murine Model of Buckwheat Allergy by Intragastric Sensitization of Fresh Buckwheat Flour Extract in C3H/HeJ

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S. Lee1, S. J. Oh1, M. H. Sohn2, K. E. Lee2, K. E. Kim2; 1Pediatrics, Ajou University School of Medicine, Suwon, REPUBLIC OF KOREA, 2Pediatrics, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA. Identification of Additional Allergens in Cooked Salmon L. Bardina, E. J. Vukic, H. A. Sampson, K. Beyer; Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY. Purification and IgE-Binding Properties of Peanut Allergen Ara h 6: Evidence for Cross-Reactivity With Ara h2 S. J. Koppelman1,2, G. A. H. de Jong1, M. Ertmann2, M. Wensing2, S. L. Hefle3, A. C. Knulst2, E. F. Knol2; 1Protein Technology, TNO Nutrition and Food Research, Zeist, NETHERLANDS, 2Dermatology/Allergology, University Medical Centre, Utrecht, NETHERLANDS, 3Food Allergy Research and Resources Program, University of Nebraska, Lincoln, NE. Oral Administration of Endotoxins Modulates AllergenInduced Immune Reactions in a Rat Model of Food Allergy D. Quarcoo1, B. Ahrens1, A. Meeuw1, G. Reese2, S. Vieths2, E. Hamelmann1; 1Department of Pediatric Pneumology and Immunology, Charité-Humboldt Universitiy, Berlin, GERMANY, 2Department of Allergology, Paul-Ehrlich Institute, Langen, GERMANY. Microarray Immunoassay (MIA) for the Parallel IgE and IgG4 Epitope Mapping of Milk Allergens W. G. Shreffler, L. Bardina, D. Lencer, K. Beyer, H. A. Sampson; Jaffe Food Allergy Institute, Department of Pediatrics, Division of Allergy & Immunology, Mount Sinai Medical Center, New York, NY. Mutational Analysis of the Cashew Vicilin Allergen, Ana o 2 P. D. Tawde; Biological Sciences, Florida State University, Tallahassee, FL. IgE Binding to and Cross-Reactivity Among English Walnut and Other Walnut (Juglans) Species S. S. Comstock1, G. McGranahan2, W. R. Peterson1, S. S. Teuber1; 1Internal Medicine, University of California, Davis, Davis, CA, 2Pomology, University of California, Davis, Davis, CA. Immunochemical Analyses for Food Residues Can Be Used To Confirm Presence of Hidden Allergens in Food Implicated in Consumer Complaints S. L. Tayolr1, S. L. Hefle1, D. M. Lambrecht1, L. M. Niemann1, A. Muñoz-Furlong2; 1Food Allergy Research and Resource Program University of Nebraska, Lincoln, NE, 2Food Allergy and Anaphylaxis Network, Farifax, VA. A New Technique to Produce Hypoallergenic Soybean Proteins Using Three Different Fermenting Microorganism J. O. Lee1, S. I. Lee2, S. H. Cho3, C. K. Oh3, C. H. Ryu1; 1Division of Applied Life Science, Gyeongsang National University, Jinju, REPUBLIC OF KOREA, 2Pediatrics, Samsung Medical Center, Seoul, REPUBLIC OF KOREA, 3Pediatrics, HarborUCLA Medical Center, Torrance, CA. Monitoring of the Cleaning Process of an Industrial Production Unit – A Model Study on Contaminations With Hidden Peanut and Celery Allergens O. Stephan, N. Weisz, S. Vieths; Department of Allergology, PaulEhrlich Institut, Langen, GERMANY.

Poster Session 4410 Monday, March 22 11:00 AM to 12:00 PM Anaphylaxis 855 Use of EpiPen® Among Parents of Children With Food Allergies J. S. Kim1, J. M. Sinacore2, J. A. Pongracic1; 1Allergy & Immunology, Children’s Memorial Hospital, Chicago, IL, 2Children’s Memorial Hospital, Chicago, IL.

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A Survey: How Pediatricians Manage Food-Induced Anaphylaxis P. Ponda1, J. Wang2, A. NowakWegrzyn1; 1Clinical Immunology, Mount Sinai School of Medicine, New York, NY, 2Pediatrics, Mount Sinai School of Medicine, New York, NY. Anaphylaxis: A Review Of 593 Cases L. Webb1, E. Greene1, P. L. Lieberman2; 1Allergy and Immunology, Univ TN College Medicine, Memphis, TN, 2Medicine and Pediatrics, Univ TN College Medicine, Memphis, TN. Anticipatory Anaphylaxis Management in a Children’s Hospital Allergy Clinic: A Quality Assurance Audit of Physician and Nurse Recommendations and Teaching C. A. Gillespie, F. Ernst, S. S. Goritz, C. Kosowan, N. Parent, W. T. A. Watson, A. B. Becker, F. E. R. Simons; Pediatric Allergy, University of Manitoba, Winnipeg, MB, CANADA. IgG: Blocking and Mediating Anaphylaxis R. T. Strait1, S. C. Morris2, F. D. Finkelman2,3; 1Emergency Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Internal Medicine, Division of Immunology, University of Cincinnati/VAMC, Cincinnati, OH, 3Allergy/Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. Subcutaneous Tissue Depth Differences Between Males and Females: The Need for Gender Based Epinephrine Needle T. T. Song, M. R. Nelson, J. N. Hershey, B. A. Chowdhury; Department of Allergy & Immunology, Walter Reed Army Medical Center, Washington, DC. Anaphylaxis to Beef, Gelatin and Haemaccel R. J. A. Mullins1, E. Apostolou2; 1Department of Science & Design, University of Canberra, Canberra, AUSTRALIA, 2Department of Allergy, Immunology & Respiratory Medicine, Monash University/Alfred Hospital, Melbourne, AUSTRALIA. Premature Testing of Allergen-Specific IgE Post-Anaphylaxis May Cause False Negative Results W. A. C. Sewell1, P. C. Dore2; 1Path Links Immunology, Scunthorpe, UNITED KINGDOM, 2Immunology Department, Hull Royal Infirmary, Hull, UNITED KINGDOM. Anaphylaxis to Algae P. S. Hutcheson, H. C. Gray, R. G. Slavin; Department of Internal Medicine, Division of Allergy, Saint Louis University School of Medicine, St. Louis, MO. Anaphylaxis Caused by Ipomoea Batatas A. Velloso, M. Baeza, P. Tornero, T. Herrero, M. Fernández, M. Rubio, M. De Barrio; Hospital General Universitario Gregorio Marañon, Madrid, SPAIN. Anaphylaxis to Honeysuckle Nectar W. Spiegel; Allergy & Asthma Specialists, Blue Bell, PA. Hospital Admissions for Anaphylaxis, Urticaria, and Angioedema in New York State A. D. Teitel1, R. Y. Lin2, M. Shamis2; 1Medicine, St. Vincents Hospital, Manhattan-SVCMC, New York, NY, 2Medicine, St. Vincents Hospital, Manhattan-SVCMC/NYMC, New York, NY. Shrimp Ingestion Dependent Exercise Induced Anaphylaxis C. J. Vital, C. Baggett, S. Kamboj, P. Kumar; Allergy & Immunology, LSU Health Sciences Center-New Orleans, New Orleans, LA. Anaphylaxis to Honeysuckle W. Spiegel; Allergy & Asthma Specialists, Blue Bell, PA. Epinephrine - Not a ‘One Size Fits All’ Drug L. Capuano1, M. Michelis2, T. Selvaggi2, A. Oughourli2; 1Immunology, Hackensack University Medical Center, Hackensack, NJ, 2The Center for Allergy, Asthma and Immune Disorder, Hackensack University Medical Center, Hackensack, NJ. Severe Anaphylaxis in a Patient on Coreg (Carvedilol) C. L. Holland; Allergy and Immunology Associates of Ann Arbor PC, Ann Arbor, MI. Anaphylaxis Caused by the Pectin Component of Barium Sulphate Suspension

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E. Hernández-García1, M. de las Heras1, B. Bartolomé2, E. Compés1, J. Sastre1, J. Cuesta1; 1Fundación Jiménez Díaz, Madrid, SPAIN, 2Bial-Aristegui laboratories, Bilbao, SPAIN. Case Report: Intraoperative Anaphylaxis Secondary to Latex Allergy Revealed After Subsequent Reaction to Peach K. I. Lenchner, A. M. Ditto; Allergy-Immunology, Northwestern University, Chicago, IL. Cross-Reactivity From Poppy Seed to Buckwheat in a Food Allergic Patient With Poppy Seed Anaphylaxis T. Oppel, P. Thomas, B. Przybilla, A. Wollenberg; Dept. of Dermatology and Allergy, Ludwig-Maximilians-University, Munich, GERMANY. Anaphylaxis to Centipede Bite P. Supakthanasiri, K. Ruxrungtham, J. Klaewsongkram, H. Chantaphakul; Division of Allergy and Immunology, Department of Medicine, Chulalongkorn University, Bangkok, THAILAND.

Poster Session 4411 Monday, March 22 11:00 AM to 12:00 PM Cytokines in Allergy 876 Elevated Interleukin-18 Levels in Bronchoalveolar Lavage Fluid of Patients With Eosinophilic Pneumonia S. Katoh1, N. Matsumoto1, K. Matsumoto1, K. Fukushima2; 1Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, JAPAN, 2Internal Medicine, Nagasaki Prefecture Tarami Hospital, Nagasaki, JAPAN. 877 Reduced Interleukin-10 Secretion at Birth Is Associated With Sensitization to Furred Pets During Early Childhood C. J. Tisler1, M. Evans2, D. DaSilva1, K. Roberg1, R. Gangnon2, J. E. Gern1, R. F. Lemanske, Jr.1; 1Pediatrics, University of Wisconsin-Madison, Madison, WI, 2Biostatistics and Medical Informantics, University of Wisconsin-Madison, Madison, WI. 878 Effect of Tetanus Immunization on T Helper (Th) Cytokine Production in Adults With and Without Allergic Rhinitis J. Trecki1, D. Gentile1, T. Fausnight2, A. Patel1, B. Angelini1, D. Skoner1; 1Department of Pediatrics, Allegheny General Hospital, Pittsburgh, PA, 2Department of Pediatrics, Hershey Medical Center, Hershey, PA. 879 Reduced Production of the Regulatory Cytokines IL-10 and TGF-β in Concomitant Allergy and Autoimmunity S. K. Chai1, G. Altman2, M. Yazdanbakhsh1, L. Godat3, L. C. Altman4, T. Takaro5; 1Department of Parasitology, Leiden University Medical Center, Leiden, NETHERLANDS, 2Biobehavioral Nursing and Health Systems, University of Washington, Seattle, WA, 3Asthma Inc., Seattle, WA, 4Department of Medicine, University of Washington, Seattle, WA, 5Department of Environmental Health, University of Washington, Seattle, WA. 880 Macrophage Migration Inhibitory Factor (MIF) in Allergic Rhinitis Y. Nakamaru1, N. Oridate1, D. Takagi1, Y. Furuta1, J. Nishihira2, S. Fukuda1; 1Otolaryngology Head and Neck Surgery, Hokkaido Univ. Graduate School of Med., Sapporo, JAPAN, 2Molecular Biochemistry, Hokkaido Univ. Graduate School of Med., Sapporo, JAPAN. 881 Cow’s Milk-Specific T Cell Reactivity of Children With and Without Persistent Cow’s Milk Allergy; Key Role for IL-10 E. F. Knol1, M. Tiemessen1, A. G. Van Ieperen-Van Dijk1, J. Garssen2, C. A. F. Bruijnzeel-Koomen1, E. Van Hoffen1; 1Dermatology/Allergology, UMC Utrecht, Utrecht, NETHERLANDS, 2Numico Research, Wageningen, NETHERLANDS. 882 Albuterol Preferentially Increases IL-4 Over IFN-γ Release From Respiratory Syncytial Virus-Stimulated Peripheral Blood Mononuclear Cells

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J. A. Wendt1, H. Li1, M. Peeples1, S. Sietsema1, J. N. Moy1,2; 1Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL, 2Department of Pediatrics, Cook County Medical Center, Chicago, IL. Mediator Measurements During an Artificial Allergy Season: Increased IL-5 and Eosinophilic Cationic Protein (ECP) but no Evidence of Priming R. A. McDermott, H. Nelson, S. Dreskin; Allergy and Immunology, University of Colorado Health Sciences Center and National Jewish Medical and Research Center, Denver, CO. The Ability of IL-4 to Substitute for IL-13 in Regulating Pulmonary Allergy in IL-13-/- Mice Is Dependent on a Thre49Ile Polymorphism in the Extracellular Domain of IL-4Ralpha D. C. Webb; John Curtin School of Medical Research, Canberra, AUSTRALIA. High Yield and Purity of Cells Were Obtained for In Vitro Studies on T Cell Cytokine Production With Human Tonsillar Mononuclear Cells in Allergic Patients B. Li1, D. Y. Wang2, F. T. Chew3; 1National University of Singapore, Singapore, SINGAPORE, 2Department of Otolaryngology, National University of Singapore, Singapore, SINGAPORE, 3Department of Biological Sciences, National University of Singapore, Singapore, SINGAPORE. The Effect of Recombinant Il-8 on Eosinophils’ Migration In Vitro and In Vivo M. Bochen´ ska-Marciniak, M. Kupczyk, P. Górski, P. Kuna; Dept of Pneumonology and Allergy, Medical University of Lodz, Lodz, POLAND. Endogenous IL-10 Production by Murine Bone MarrowDerived Dendritic Cells (BMDC) Directs T-Cell Priming B. Ahrens, A. Dittrich, X. Hu, T. Freund, D. Quarcoo, E. Hamelmann; Department of Pediatric Pneumology and Immunology, Charité-Humboldt Universitiy, Berlin, GERMANY. The RNA Binding Protein, HuR, Posttranscriptionally Regulates the Expression of Chemokines and Cytokines U. Atasoy1, S. Curry2, C. Stellato2, J. D. Keene1; 1Duke University Medical Center, Durham, NC, 2Johns Hopkins, Baltimore, MD. Modulation of Expression of B7 Homologs by Human Rhinovirus and Double-Stranded RNA in Airway Epithelial Cells In Vitro and In Vivo J. Kim1, S. Sanders1, J. Plitt1, D. Pardoll2, L. Chen3, R. Schleimer1; 1Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, 2OncologyImmunology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Immunology, Mayo Medical School, Rochester, MN.

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Poster Session 4412 Monday, March 22 11:00 AM to 12:00 PM T Cells in Allergy 890 Cellular Pathology of Allergic Airway Inflammatory Responses to Ovalbumin (OVA) Following Adoptive Transfer of CD4+ T Lymphocytes to Naive Rats K. J. Escott1, M. Dearman1, M. Foster2, A. Bahl1; 1Discovery Bioscience, AstraZeneca R&D Charnwood, Loughborough, UNITED KINGDOM, 2Safety Assessment, AstraZeneca R&D Charnwood, Loughborough, UNITED KINGDOM. 891 Lymphocytes in Peyer’s Patches Regulate Clinical Tolerance in a Murine Model of Food Allergy P. A. Eigenmann1, L. Tropia1, C. Hauser2, C. P. Frossard1; 1University Children’s Hospital, Geneva, SWITZERLAND, 2Department of Medicine, University Hospital, Geneva, SWITZERLAND. 892 Activation of Monocytes by Cysteinyl Leukotrienes (CysLT) in a CysLT2 Receptor-Dependent Fashion

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K. J. Roelofs, K. Hise, L. Borish, J. W. Steinke; Asthma and Allergic Disease Center, University of Virginia, Charlottesville, VA. Murine Airways Contain Mature Dendritic Cells That Retain the Capacity To Activate T Cells M. H. Grayson, M. M. Rohlfing, M. J. Holtzman; Department of Medicine, Washington Univ. School Med., Saint Louis, MO. Dendritic Cell Expression of FcepsilonRI Is Regulated by Serum IgE B. Foster1, D. T. Griffith2, K. M. Boesel2, H. Lin2, T. B. Casale2, D. D. Metcalfe1, C. Prussin1; 1NIAID/NIH, Bethesda, MD, 2Creighton University, Omaha, NE. Time Course of Allergen Induced Nitric Oxide Synthase mRNA Expression in Mice Model of Anaphylaxis K. Sade, S. Etkin, S. Kivity; Allergy and Asthma Center, Tel-Aviv Sourasky Medical Center, Tel-Aviv, ISRAEL. The Effects of Osteopontin (OPN) on Human CD4+ T Cells J. A. Eckman, S. Konno, S. Huang; Johns Hopkins Asthma and Allergy Center, Baltimore, MD. The Drug Pump Multi-Drug Resistance Protein 1 (MRP1) Is Induced Upon T Cell Activation and Its Inhibition Blocks T Cell Function M. A. Alston, J. Zhang, H. Huang, R. L. Rabin; FDA, Bethesda, MD. CTLA-4 Expression in T Cells in Patients With Atopic Dermatitis S. Choi, M. Sohn, B. Kwon, K. Kim; Pediatrics, Yonsei University of College Medicine, Seoul, REPUBLIC OF KOREA. Evidence of Immune Dysregulation to Cat Allergen in Sensitized Patients With Atopic Dermatitis L. Gesicki1, A. Reefer1, T. Platts-Mills1, N. Custis1, B. Wilson2, J. Woodfolk1; 1Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA, 2Department of Dermatology, University of Virginia, Charlottesville, VA. Potential Role of KDAF in Regulation of Airway Remodeling in Asthma N. Asdaghi1, A. Ghahary2, R. Moqbel1; 1Department of Medicine, University of Alberta, Edmonton, AB, CANADA, 2Department of Surgery, University of Alberta, Edmonton, AB, CANADA. Paramyxoviral-Induced Lung Dendritic Cell Maturation Occurs Independently of CCR5 Function M. S. Ramos1, M. M. Rohlfing1, M. J. Holtzman2, M. H. Grayson1; 1Division of Allergy and Immunology, Washington University School of Medicine, St. Louis, MO, 2Division of Pulmonary and Critical Care, Washington University School of Medicine, St. Louis, MO. Periimplantar Cobalt-Specific DTH Reaction in a Patch Test Negative Patient With Failure of Hip Arthroplasty A. Schoberl1, B. Summer1, K. Jakob2, S. Barnstorf1, P. Thomas1; 1Dept. of Dermatology, Ludwig-Maximilians-University Munich, Munich, GERMANY, 2Dept. of Surgery, Amper Klinik, Munich, GERMANY. ICOS Expression Is Associated With Local Immunoglobulin E (IgE) Production in Lung Tissue Following Allergen Airway Challenge K. C. Beier1, T. Kallinich1, M. Löhning2, A. Hutloff3, R. A. Kroczek3, E. Hamelmann1; 1Pediatric Pneumology and Immunology, Charité - Humboldt University, Berlin, GERMANY, 2Institute for Experimental Immunology, University Hospital Zurich, Zurich, SWITZERLAND, 3Molecular Immunology, Robert Koch-Institute, Berlin, GERMANY. Characterization of T Cell Responses in Peanut-Allergic Patients by Polychromatic Flow Cytometry R. R. Castro, W. G. Shreffler, L. S. Pei-Chi, H. A. Sampson; Jaffe Food Allergy Institute, Department of Pediatrics, Division of Allergy & Immunology, Mount Sinai Medical Center, New York, NY. Rab and SNARE Isoform Expression in Cytotoxic T-Cells

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(CTL): Potential Players in Regulated Release of Granzyme-B (GrB) D. L. Garofoli1, S. O. Odemuyiwa1, M. R. Logan1, K. Lo1, R. C. Bleackley2, R. Moqbel1; 1Department of Medicine, University of Alberta, Edmonton, AB, CANADA, 2Department of Biochemistry, University of Alberta, Edmonton, AB, CANADA. Allergen-Specific Cytokine Production in Human Peripheral Blood Mononuclear Cells From Peanut-Allergic Subjects In Vitro J. Sun, B. Wong, M. Conway, A. Dalrymle, B. Kim, S. Goncharova, S. Waserman, M. Jordana; McMaster University, Hamilton, ON, CANADA. Asthma-Like Disease and Chemokine Dysregulation in the Lung of T Cell-Deficient Mice L. L. Chan1, J. M. Crawford1, M. G. Tu2, T. Chan2; 1Human Biological Chemistry & Genetics, University of Texas Medical Branch, Galveston, TX, 2Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX. Activation of Nuclear Factor of Activated T Cells (NFAT) Molecular Species by Aspirin (Acetylsalicylic Acid: ASA) in Human T Cells A. S. Hellquist1, U. De Fanis2, T. S. L. Holland2, V. Gupta2, R. J. Kurnat2, A. Cianferoni3, V. Casolaro2; 1Department of Biosciences at Novum, Karolinska Institutet, Stockholm, SWEDEN, 2Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, MD, 3Department of Pediatrics, Harvard Medical School, Boston, MA. Surfactant Protein (SP)-D Suppresses Antigenic and Mitogenic T Cell Activation In Vitro G. Vass, S. Scanlon, M. Beers, A. Haczku; Department of Medicine, University of Pennsylvania, Philadelphia, PA.

Oral Abstract Session

MONDAY

4601 Monday, March 22 1:30 PM to 2:45 PM Identification of Risk Factors Associated With Asthma 1:30 910 Three Year Examination of Trends in Asthma-Related Utilization Demonstrate Significant Variation in Resource Consumption D. Stempel1, A. L. Fuhlbrigge2, T. McLaughlin3, T. B. Pendergraft4, R. Stanford4; 1University of Washington, Seattle, WA, 2The Channing Laboratory, Brigham and Women’s Hospital, Boston, MA, 3NDCHealth, Phoenix, AZ, 4GlaxoSmithKline, Research Triangle Park, NC. 1:45 911 Pediatric Asthma Revisits to the ED and the Role of Primary Care Physicians Versus Asthma Specialists A. Lateef, S. J. McGeady, E. Yousef; Allergy and Immunology, Thomas Jefferson University, Philadelphia, PA. 2:00 912 Relationship of Exhaled Nitric Oxide to Asthma Severity and Phenotypes A. M. Lent, A. A. Busacker, S. E. Wenzel, P. E. Silkoff; Department of Medicine, National Jewish Medical and Research Center, Denver, CO. 2:15 913 Specialist Asthma Care Results in Superior Assessment of Asthma Control J. T. Li1, M. Schatz2, C. A. Sorkness3, J. J. Murray4, P. Marcus5, R. A. Nathan6, T. B. Pendergraft7, M. Kosinski8, R. H. Stanford7; 1Mayo Medical Center, Rochester, MN, 2Kaiser-Permanente Medical Center, San Diego, CA, 3University of Wisconsin, Madison, WI, 4Vanderbilt University Medical Center, Nashville, TN, 5New

York College of Osteopathic Medicine, Old Westbury, NY, 6Asthma and Allergy Associates, Colorado Springs, CO, 7GlaxoSmithKline, Research Triangle Park, NC, 8QualityMetric, Inc., Lincoln, RI. 2:30 914A Distinguishing Asthma Phenotypes: Role of Age of Onset and Eosinophilic Inflammation S. E. Wenzel, C. Miranda, A. Busacker, J. Trudeau, S. Balzar; National Jewish Medical and Research Center, Denver, CO.

Oral Abstract Session 4602 Monday, March 22 1:30 PM to 2:45 PM Immunologic Changes Associated With IT 1:30 914 Efficient Anti-IgE Vaccination Without Anaphylactogenic Properties Å. Jansson, A. Fuentes, A. Magnusson, E. Landström, B. Öhman, Å. Kälvesten, L. Hellman, B. Sparf, S. Persson, M. Lundgren; Resistentia Pharmaceuticals AB, Uppsala, SWEDEN. 1:45 915 Induction of Oral Tolerance by CpG-ODNs in a Murine Model of Asthma J. N. Kline, K. Kitagaki, T. Businga; Pulmonary Medicine, University of Iowa, Iowa City, IA. 2:00 916 Allergen Peptide Immunotherapy in Humans Inhibits Allergen-Induced Proliferation of CD4+ T Cells But Does Not Affect Suppressive Activity of CD4+CD25+ T Cells T. R. Smith, C. Alexander, A. B. Kay, M. Larche, D. S. Robinson; Allergy and Leukocyte Biology, Imperial College London, London, UNITED KINGDOM. 2:15 917 Immunological Response to Administration of Standardized Cat Allergen Extract at Differing Doses A. Nanda, M. O’Connor, W. Wheat, J. Routes, M. Anand, D. Fifield, S. Dreskin, L. Rosenwasser, H. Nelson; Allergy and Immunology, National Jewish Medical and Research Center, Denver, CO. 2:30 918 Allergen-Based Peptide Immunotherapy Is Associated With Functional Modifications in Allergen-Specific T-Cell Subpopulations A. Verhoef, C. Alexander, A. B. Kay, M. Larché; Allergy and Clinical Immunology, Imperial College London, NHLI Division, London, UNITED KINGDOM.

Oral Abstract Session 4603 Monday, March 22 1:30 PM to 2:45 PM Immunodeficiency 1:30 919 Wiskott-Aldrich Protein (WASP) Is Important for NFAT and AP1 Activation A. Cianferoni, N. Ramesh, M. Gallego, R. S. Geha; Immunology, Boston Children’s Hospital, Harvard University, Boston, MA. 1:45 920 Increased Infections With Herpes Virus 8 (HHV8) in Patients With Common Variable Immunodeficiency (CVID) and Granulomatous and Lymphoproliferative Interstitial Lung Disease (GLILD) W. H. Wheat1, P. R. Rai2, C. A. Bates3, C. D. Cool1, K. K. Brown1,

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2:00 921 Natural Killer (NK) Cells and Bone Marrow Transplant (BMT) in Severe Combine Combined Immunodeficiency (SCID) R. G. Piltch1, S. C. Grambow2, R. H. Buckley2; 1Allergy Department, The Permanente Medical Group, Pleasanton, CA, 2Duke University Medical Center, Durham, NC. 2:15 922 Green Tea Polyphenol Epigallocatechin Gallate Binding to CD4 as a Model for the Inhibition of HIV-1-gp120 Binding to CD4+ T Cells T. G. McCormick1, C. L. Nance2, M. P. Williamson3, W. T. Shearer1; 1Baylor College of Medicine, Houston, TX, Houston, TX, 2Texas Children’s Hospital, Houston, TX, 3University of Sheffield, England, UNITED KINGDOM. 2:30 923 Gene-Chip Array Study of an Immunodeficiency Patient With Idiopathic Bacillus Calmette-Guerin (BCG) Infection and Mucocutaneous Candidiasis T. H. Tsai1,2, K. D. Yang3, S. K. Huang1; 1Johns Hopkins Asthma and Allergy Center, Baltimore, MD, 2Municipal Wan Fang Hospital, Taipei, TAIWAN REPUBLIC OF CHINA, 3Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TAIWAN REPUBLIC OF CHINA.

Oral Abstract Session 4604 Monday, March 22 1:30 PM to 2:45 PM Mechanisms of Chronic Urticaria 1:30 924 Hypersensitivity to Aspirin: Common Eicosanoid Alterations in Urticaria and Asthma L. Mastalerz, M. Setkowicz, M. Sanak, A. T. Szczeklik; Department of Medicine, Jagiellonian University School of Medicine, Krakow, POLAND. 1:45 925 The Effects of the Calcineurin Inhibitors Cyclosporin and Ascomycin on an In-Vitro Assay for Autoimmune Urticaria A. M. Marsland; MUSC, Charleston, SC. 2:00 926 Anti-C1q Antibodies in Patients With Chronic Idiopathic Urticaria J. V. Garmendia, L. E. Muñoz, M. Zabaleta, P. Tassinari, N. E. Bianco; Allergy and Clinical Immunology, Instituto de Inmunologia, Universidad Central de Venezuela, Caracas, VENEZUELA. 2:15 927 Chronic Urticaria in Children: An Autoimmune Disease? C. S. Miyahara, L. R. Roberti, V. P. L. Ferriani, L. K. Arruda; Pediatrics, School of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, SP, BRAZIL. 2:30 928 Evidence of In Vivo Basophil Activation in Chronic Idiopathic Urticaria K. Vasagar, B. M. Vonakis, A. Viksman, S. Gibbons, Jr., S. S. Saini; JHAAC, Baltimore, MD.

Oral Abstract Session 4605 Monday, March 22 1:30 PM to 2:45 PM Pollutants and tobacco Smoke as Risk Factors for Asthma 1:30 929 Relationship Between Airway Phagocyte CD11b and CD14 Expression and Ozone-Induced Airway Inflammation in Human Volunteers N. E. Alexis1, S. Becker2, P. Bromberg3, R. Devlin2, D. Peden1; 1Pediatrics, UNC Chapel Hill, Chapel Hill, NC, 2Human Studies Division, US EPA, Chapel Hill, NC, 3Medicine, UNC Chapel Hill, Chapel Hill, NC. 1:45 930 Environmental Tobacco Smoke Exposure During the First 10 Years of Life: A Risk Factor for Allergic and Non-Allergic Airway Disorders? M. Kulig1, T. Keil1, S. Roll1, S. Lau2, C. Grueber2, R. Nickel2, U. Wahn2; 1Institute of Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, GERMANY, 2Department of Pediatric Pneumology and Immunology, Charité University Medical Center, Berlin, GERMANY. 2:00 931 ETS as a Factor in Asthma Morbidity in an Urban Pediatric Population N. Budhiraja1, M. D. Klinnert1, L. R. Anderson1, M. Anderson2, G. Faries3, R. Balkissoon1, J. Seelye1, M. Hovell4; 1Pediatrics, National Jewish Medical and Research Center, Denver, CO, 2Pediatrics, Denver Health, Denver, CO, 3Emergency Department, The Children’s Hospital, Denver, CO, 4Center for Behavioral Epidemiology and Community Health, San Diego State University, San Diego, CA. 2:15 932 Decreased Risk of Atopy With Early Pet Exposure Is Dependent on Parental Smoking Behavior D. R. Ownby1, E. L. Peterson2, C. C. Johnson2; 1Pediatrics, Medical College of Georgia, Augusta, GA, 2Biostatistics, Henry Ford Health System, Detroit, MI. 2:30 933 Do Animals Significantly Increase Indoor Endotoxin Exposure? N. Custis, J. Woodfolk, T. Platts-Mills; University of Virginia, Charlottesville, VA.

Oral Abstract Session 4606 Monday, March 22 1:30 PM to 2:45 PM Treatment of Anaphylaxis 1:30 934 Intramuscular (IM) Injection of Epinephrine in Adults: What Is the Optimal Interval Between Doses? F. E. R. Simons, X. Gu, K. J. Simons; Pediatric Allergy, University of Manitoba, Winnipeg, MB, CANADA. 1:45 935 Biphasic Anaphylaxis: A Prospective Examination of 103 Patients for the Incidence and Characteristics of Biphasic Reactivity A. K. Ellis1, J. H. Day2; 1Queen’s University, Kingston, ON, CANADA, 2Division of Allergy & Immunology, Queen’s University, Kingston, ON, CANADA. 2:00 936 Treatment of Anaphylaxis in the Outpatient Setting B. R. Haymore1, W. T. Frank2, W. W. Carr3; 1Department of Med-

MONDAY

C. H. Kirkpatrick4, B. A. Lindenbaum1, A. E. Serls2, M. Ellison1, J. M. Routes1; 1Immunology, NJMRC, Denver, CO, 2Pathology, UCHSC, Denver, CO, 3NJMRC, Denver, CO, 4UCHSC, Denver, CO.

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icine, William Beaumont Army Medical Center, El Paso, TX, 2Dept of Allergy and Immunology, William Beaumont Army Medical Center, El Paso, TX, 3Dept of Allergy and Immunology, Walter Reed Army Medical Center, Washington, DC. 2:15 937 A Placebo- and Active Comparator-Controlled Dose Escalation Study of the Pharmacokinetics, Pharmacodynamics, and Safety of Inhaled Large Porous Particle (AIR®) Epinephrine in Normal Volunteers J. Dunbar1, A. Illeperuma1, J. Milovanovic1, J. Loewy1, C. Osborn1, P. Ahluwalia2, J. Richards2, E. W. Ehrich1; 1Alkermes, Inc., Cambridge, MA, 2Leicester Clinical Research Clinic, PPD Development, Leicester, UNITED KINGDOM. 2:30 938 Sublingual Epinephrine Administration in Humans: A Preliminary Study K. J. Simons, X. Gu, F. E. R. Simons; Pediatric Allergy, University of Manitoba, Winnipeg, MB, CANADA.

Oral Abstract Session 4607 Monday, March 22 1:30 PM to 2:45 PM

MONDAY

Quality of Care for Asthma 1:30 939 The Prevalence of Low Risk Asthma in Adults in a Large Health Care Program: An Audit for Diagnostic Accuracy E. M. Macy, C. Gibbons, M. Schatz; Allergy, SCPMG-Kaiser Permanente San Diego, San Diego, CA. 1:45 940 Assessment of Recruitment and Retention Strategies in a Birth Cohort Study Evaluating Asthma Inception in Early Childhood K. A. Roberg, K. T. Carlson-Dakes, E. L. Anderson, D. F. DaSilva, H. J. Hiemke, J. E. Gern, R. F. Lemanske, Jr.; Allergy Asthma Research, UW Medical School, Madison, WI. 2:00 941 Associations Between Medication and Disease Beliefs and Use of Inhaled Corticosteroids Among Inner City Adults With Persistent Asthma E. A. Halm1, A. Cooperman2, H. Leventhal3; 1Medicine and Health Policy, Mount Sinai School of Medicine, New York, NY, 2Health Policy, Mount Sinai School of Medicine, New York, NY, 3Psychology, Rutgers University, New Brunswick, NJ. 2:15 942 Analysis of Pediatric Asthma Patients Presenting to the Emergency Room Using a Web Based Tracking System K. J. Kelly1, C. M. Walsh-Kelly2, E. Barthell3, S. Rogalinski3, P. Christenson3, L. Grabowski1; 1Allergy/Immunology, Medical College of Wisconsin, Milwaukee, WI, 2Pediatric Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, 3Infinity Health Care, Mequon, WI. 2:30 943 How Closely Does the Care of Asthmatic Children at an Inner City Family Medicine Practice Match the 1997 National Asthma Education and Prevention (NAEPP) Guidelines?: Perception and Reality V. Nazarov1, J. Fifield2, E. Jackson2; 1Department of Pediatrics, Louisiana State University Medical Center, School of Medicine, New Orleans, LA, 2Department of Family Medicine, University of Connecticut School of Medicine, Farmington, CT.

Oral Abstract Session 4608 Monday, March 22 1:30 PM to 2:45 PM Allergic Inflammation 1:30 944 Transplacental Transmission of Dust Mite Antigen A. H. Bahrainwala1, I. Al-Sanouri1, P. M. Long2, J. Kaplan1; 1Pediatrics, Wayne State University, Detroit, MI, 2Pathology, Wayne State University, Detroit, MI. 1:45 945 Pollen Associated Lipid Molecules (PALMs) Modulate Dendritic Cell Function Leading to a Reduced Capacity to Initiate Th1 Responses C. Traidl Hoffmann, V. Mariani; Centrum Allergy and Umwelt, Dermatology, Munich, GERMANY. 2:00 946 Identification of FcgammaRIIB Receptor as a Physiologic Inhibitor of Allergic Airway Inflammation N. G. Dharajiya1, B. Choudhury1, B. Clancy2, R. Alam3, S. Sur1; 1Allergy & Immunology, UTMB, Galveston, TX, 2Wyeth Erst, Andover, MA, 3National Jewish Medical Center, Denver, CO. 2:15 947 Involvement of CCL18 in Inflammatory Allergic Diseases P. de Nadaï; U416, Institut Pasteur de Lille, Lille, FRANCE. 2:30 948 Bronchial Hyperresponsiveness in Experimental EosinophilAssociated GI Diseases Is Critically Regulated by CD4+ TCells, Interleukin-13 and Eotaxin S. P. Hogan1, E. Forbes1, V. E. Smart1, A. D’Aprile2, P. Henry2, M. E. Rothenberg3, P. S. Foster1; 1Molecular Bioscience, John Curtin School of Medical Research, Canberra, AUSTRALIA, 2Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Western Australian Institute for Medical Research, Perth, AUSTRALIA, 3Pediatrics, Childrens Hospital Medical Center, Cincinnati, OH.

Poster Session 5401 Tuesday, March 23 11:00 AM to 12:00 PM Asthma Mechanisms and Infections 949 Hydroxychloroquine (HCQ) Inhibits Rhinovirus (RV) Replication in Cultured Human Tracheal Epithelial Cells W. E. Finkbeiner1, B. L. Charous2, G. Dolganov3, J. H. Widdicombe4; 1Department of Pathology, University of California, Davis, Davis, CA, 2Allergy and Respiratory Care Center, Advanced Healthcare, Milwaukee Medical Clinic, Milwaukee, WI, 3Department of Medicine, University of California, Davis, California, CA, 4Department of Human Physiology, University of California, Davis, Davis, CA. 950 Gender Based Differences in Eosinophilic Inflammation, Pulmonary Function and Subjective Symptoms in Patients With Severe Asthma C. Miranda; Medicine/Clinical Research, National Jewish Medical and Research Center, Denver, CO. 951 Are Chlamydia pneumoniae and Mycoplasma pneumoniae Important Etiological Agents of Respiratory Tract Infections in a Family Practice Setting? J. D. Hester1, D. L. Hahn2; 1IBT Reference Laboratory, Lenexa, KS, 2Dean Medical Center, Madison, WI. 952 Mechanisms of Viral Impact on Asthma Exacerbations M. R. Khaitov1, D. U. Trofimov1, T. V. Petrova1, K. P. Yakovleva1, M. N. Boldyreva1, M. N. Yartsev1, N. I. Ilina1, L. M. DuBuske2, L.

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P. Alexeev1; 1Institute of Immunology, Moscow, RUSSIAN FEDERATION, 2Immunology Research Institute of New England, Fitchburg, MA. Rhinovirus-Induced Activation of Intracellular Signaling Events in Human Monocytes and Alveolar Macrophages N. L. Korpi, E. N. Chapman, M. E. Bates, P. J. Bertics; Biomolecular Chemistry, University of Wisconsin, Madison, WI. Evaluating Elastic Recoil of the Lung in Pediatric Asthma K. Paull, R. Cherniack, E. Gelfand, J. Spahn; National Jewish Med & Rsrch Ctr, Denver, CO. Cross-Talk Between ERK-1/2 and STAT-1-Alpha Pathways in Respiratory Syncytial Virus-Induced Early Gene Expression in Human Epithelial Cells X. Kong1,2, H. San Juan1,2, A. Behera1, R. F. Lockey1,2, S. S. Mohapatra1,2; 1Dept. of Internal Medicine, Div. of Allergy and Immunology, University of South Florida, Tampa, FL, 2VA Hospital, Tampa, FL. Childhood Asthma: Quantification of the Bronchodilator Response by Impulse Oscillometry System J. M. Olaguibel, M. Alvarez-Puebla, M. Anda, B. Gomez, B. E. Garcia, A. I. Tabar; Dept. Allergy, Hospital Virgen Del Camino, Pamplona, SPAIN. Prostaglandin EP Receptor Agonists Differentially Modulate Aspirin-Induced Generation of 15-HETE in Aspirin-Sensitive Asthmatics M. L. Kowalski1, A. Ptasinska1, M. Jedrzejczak1, B. Bienkiewicz1, M. Borowiec1, L. DuBuske2; 1Department of Allergy and Clinical Immunology, Medical University of Lodz, Lodz, POLAND, 2The Immunology Research Institute of New England, Boston, MA. Rapid Protective Effect of Inhaled Fluticasone on Airway Hyperresponsiveness to AMP in Asthma but not in COPD L. Spicuzza, V. Scuderi, G. Prosperini, G. U. Di Maria, R. Polosa; Dip. di Medicina Interna e Specialistica, University of Catania, Catania, ITALY. The pH of Exhaled Breath Condensate (EBC): A Non Invasive Tool for Evaluation of Asthma in Childhood L. Brunetti, R. Tesse, R. Francavilla, V. L. Miniello, A. Strippoli, V. De Sario, F. Fiore, L. Armenio; Department of Pediatrics, University of Bari, Bari, ITALY. Autumn Exacerbations of Pediatric Asthma in Japan Is Strongly Associated With Rhinovirus (RV) Infection M. Ebisawa, C. Sugizaki, K. Sugihara, A. Shukuya, H. Tachimoto; Pediatric Allergy, National Sagamihara Hospital, Kanagawa, JAPAN. Effects of Deep Inspiration (DI) on Respiratory Impedance Measured by Impulse Oscillometry (IOS) P. Gaylor1, M. Goldman2, C. Saadeh3, J. Malacara3, M. Gaylor3; 1Internal Medicine, Good Samaritan Hospital, University of Arizona at Phoenix, Phoenix, AZ, 2Pulmonary Medicine, UCLA, Los Angeles, CA, 3Amarillo Center for Clinical Research, Ltd., Amarillo, TX. MIP-3alpha/CCL20 Expression Is Highly Induced in Respiratory Epithelium and in Human Subjects Infected With Rhinoviruses J. M. Bellak1, K. Hanson2, W. W. Busse1, J. E. Gern2; 1Medicine, University of Wisconsin, Madison, WI, 2Pediatrics, University of Wisconsin, Madison, WI. Comprehensive Analysis of mRNA Expression Profiles in Human Respiratory Epithelial Cells After Inoculation With Respiratory Syncytial Virus Y. Yamada1,2, K. Matsumoto2, N. Hashimoto2, M. Saikusa3, A. Kato2, T. Homma2, H. Saito2, S. Yoshihara1, O. Arisaka1; 1Department of Pediatrics, Dokkyo University School of Medicine, Mibu, Tochigi, JAPAN, 2Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, JAPAN, 3Yokohama Health Research Institute, Kanagawa, JAPAN.

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Accurate Measurements of Airway Mucosal Blood Flow, a New Biomarker of Asthma: Comparison of Two Soluble Gases G. W. Clarke1, G. F. Rafferty2, R. I. Ketchell1, A. Greenough2, B. J. O’Connor1; 1Department of Asthma Allergy & Respiratory Science, King’s College, London, UNITED KINGDOM, 2Department of Child Health, King’s College, London, UNITED KINGDOM. Environmental Factors Differentially Influence the Persistence or Remission of Infantile Wheezing During the First Three Years of Life G. E. Akan1, J. E. Gern1, Z. Li2, M. D. Evans3, K. A. Roberg4, C. J. Tisler4, R. E. Gangnon2, R. F. Lemanske, Jr.5; 1Medicine, University of Wisconsin - Madison, Madison, WI, 2Biostatistics and Medical Informatics, University of Wisconsin - Madison, Madison, WI, 3Biostatistic and Medical Informatics, University of Wisconsin - Madison, Madison, WI, 4Pediatrics, University of Wisconsin Madison, Madison, WI, 5Medicine and Pediatrics, University of Wisconsin - Madison, Madison, WI. Immunohistochemical Analysis of Rhinovirus Infection of Lower Airway Tissues A. G. Mosser1, L. J. Burchell1, T. Pier1, N. Jarjour1, W. W. Busse1, J. E. Gern2; 1Department of Medicine, University of Wisconsin, Madison, WI, 2Department of Pediatrics, University of Wisconsin, Madison, WI. Immunologic Development Early in Life Following Severe Respiratory Syncytial Virus (RSV) Bronchiolitis H. Wang1, A. Rahm1, J. Bonfiglio1, K. Schechtman2, L. Bacharier3, R. Strunk3, M. Castro1; 1IM-Pulmonary Disease, Washington University in St. Louis, Saint Louis, MO, 2Biostatistics, Washington University in St. Louis, Saint Louis, MO, 3Pediatrics, Washington University in St. Louis, Saint Louis, MO. Determinants of Sputum Neutrophilia After Experimental Infection With Rhinovirus (RV) 16 R. F. Vrtis, J. E. Gern, E. A. Hanzel, W. W. Busse; Medicine, University of Wisconsin, Madison, WI. Rhinovirus (RV)-Induced Cell Proliferation Predicts Response to Experimental Infection G. D. Brooks1, K. A. Buchta1, E. A. Hazel1, J. L. Bernstein1, C. A. Swenson1, J. E. Gern2, W. W. Busse1; 1Medicine, University of Wisconsin, Madison, WI, 2Pediatrics, University of Wisconsin, Madison, WI. T Cell Response to Respiratory Syncytial Virus (RSV) B. Chi1, K. M. Spann2, P. L. Collins2, R. L. Rabin1; 1Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD, 2Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD. Comparative Thresholds for Adenosine Monophosphate (AMP) and Methacholine (MCH) Challenge Testing E. J. Fardon, T. C. Fardon, D. K. C. Lee, B. J. Lipworth; Department Of Clinical Pharmacology, Asthma And Allergy Research Group, Dundee, UNITED KINGDOM. High-Pitch Expiratory Wheeze Indicates Poor Response to Inhaling Bronchodilator in Infantile Asthmatic Fit C. Habukawa1, Y. Nagasaka2, K. Murakami3, T. Takemura4; 1Pediatrics, Minami Wakayama National Hospital, Tanabe, JAPAN, 2Pulmonology, Kinki University Sakai Hospital, Sakai, JAPAN, 3Pediatrics, Kinki University Sakai Hospital, Sakai, JAPAN, 4Pediatrics, Kinki Unisersity School of Medicine, Osakasayama, JAPAN. Passive Cigarette Smoke Exposure Acutely Decreases Pulmonary Function in Normal, Nonasthmatic Controls C. W. Raphael1, G. D. Raphael2; 1Student, Potomac, MD, 2Private Practice, Bethesda, MD. Evaluation of Airway Hyperresponsiveness and Bronchoalveolar Lavage Fluid in a Fisher (F344) Rat Model of Alternaria Sensitization

TUESDAY

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J. J. Prochnau1, H. Sanchez2, R. L. Sorkness3, J. L. Remus3, R. K. Bush4; 1Allergy and Immunology, University of Wisconsin, Madison, WI, 2Research, William S. Middleton Veterans Memorial Hospital, Madison, WI, 3Pharmacy, University of Wisconsin, Madison, WI, 4Allergy and Immunology, University of Wisconsin/William S. Middleton Veterans Memorial Hospital, Madison, WI. Exhaled Nitric Oxide (eNO) in Asthma: Variability and Relation to Asthma Severity, Treatment, and Lymphocyte Activation G. P. Shome1, R. Kennedy2, M. Shearer3, A. Way4; 1Internal Medicine, Texas Tech University, Lubbock, TX, 2Microbiology & Immunology, Texas Tech University, Lubbock, TX, 3Microbiology & Immunology, Texas Tech University, Lubbock, TX, 4Epidemiology & Preventive Medicine, Texas Tech University, Lubbock, TX. Respiratory Inductance Plethysmography for the Diagnosis of Dysfunctional Breathing in Patients With Severe Asthma C. O. Prys-Picard, F. Kellett, R. M. Niven; North West Lung Centre, Manchester, UNITED KINGDOM. GM-CSF and Flt-3 Ligand Counteract a Deficient Capacity for Respiratory Virus-Induced IFN-γ Production L. A. Rosenthal1, L. D. Mikus1, R. L. Sorkness1,2, R. F. Lemanske, Jr.1; 1University of Wisconsin Medical School, Madison, WI, 2University of Wisconsin School of Pharmacy, Madison, WI. Exercise Induced Laryngeal Prolapse in Elite Atheletes – “Curable Asthma” U. S. Bjornsdottir; University Hospital Iceland, Reykjavik, ICELAND. Effect of Chronically Exposing Young Guinea Pigs to Environmental Tobacco Smoke on Cough and Bronchoconstriction, Role of NK-1 Receptors in the Nucleus Tractus Solitarius J. P. Joad1, P. A. Munch2, J. M. Bric1, S. J. Evans3, K. E. Pinkerton4, C. Chen2, A. C. Bonham2; 1Pediatrics, UC Davis, Sacramento, CA, 2Pharmacology, UC Davis, Davis, CA, 3Internal Medicine, UC Davis, Sacramento, CA, 4Veterinary Medicine, UC Davis, Davis, CA. Schistosoma mansoni Down-regulate Type 2 Immune Response and Reduce Severity of Asthma E. M. Carvalho, M. Araujo, A. Cruz, M. Almeida, E. A. Taketomi, M. Medeiros, Jr.; Medicine, Federal University of Bahia, Salvador - Bahia, BRAZIL.

Poster Session 5402 Tuesday, March 23 11:00 AM to 12:00 PM

TUESDAY

Clinical Asthma and Allergy 983 Asthma Related ED/Hospitalization Risk and Asthma Costs of Fluticasone Propionate/Salmeterol in a Single Inhaler Compared to Fluticasone Propionate and Salmeterol in Separate Inhalers D. A. Stempel1, R. H. Stanford2, J. Kim3, H. O. Chernicoff3, A. Legoretta3; 1Infomed Northwest and University of Washington, Seattle, WA, 2GlaxoSmithKline, Rtp, NC, 3Health Benchmarks Inc, Woodland Hills, CA. 984 Transitions Between Mild, Moderate and Severe Asthma States and Their Determinants: A Logistic Regression Approach B. D. Tano; Internal Medicine, Ohio State University Medical Center, Durham, NC. 985 Comparison of Allergic Status of Adopted Indian Born and Native Icelandic Children S. T. Sigurdardottir1, H. Grimsdottir1, U. S. Bjornsdottir2, M. Clausen3, G. Palsson3; 1Dept of Immunology, Landspitali University Hospital, Reykjavik, ICELAND, 2Dept of Pulmonary Medicine, Landspitali University Hospital, Reykjavik, ICELAND, 3Children’s Hospital, Reykjavik, ICELAND.

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Comparison of the Prevalence of Asthma and Severity in Public vs. Private Schools in New Orleans, LA G. Alawad, C. Moore; Pediatrics, LSU Health Sciences Center, New Orleans, LA. 987 Risk Factors for Allergic Diseases in 6-7 Year Old Schoolchildren in South East México City M. Barragán-Menjuerio, Sr.; Pediatric Allergy, Hospital Mocel, Mexico City, D.F., MEXICO. 988 Improved Asthma Quality of Life in Parents/Caregivers of Inner-City School Children Enrolled in a School-Based Asthma Management Program (SBAMP) M. Mvula, C. Moore; Pediatrics, LSU Health Sciences Center, New Orleans, LA. 989 Risk Factors for Allergic Diseases in 13-14 Year Old Schoolchildren in South East México City B. M. M. Morfin-Maciel, Jr.; Pediatric Allergy, Hospital Mocel, D.F. Mexico City, MEXICO. 990 School-Based Asthma Management Program in Inner-City New Orleans: Outcomes C. Moore, M. Mvula; Pediatrics, LSU Health Sciences Center, New Orleans, LA. 991 Risk Factors of Readmission for Childhood Asthma Y. Rha; Dept. of Pediatrics, Kyung Hee Medical Center, Seoul, REPUBLIC OF KOREA. 992 Prevalence of Positive Skin Prick Test With Inhaled Allergens and in General Population of Lodz Province’s Citizens I. R. Kuprys´, A. Elgalal, B. Korzycka-Zaborowska, P. Górski, P. Kuna; Dept of Pneumonology and Allergy, Medical University of Lodz, Lodz, POLAND. 993 Breastfeeding Less Than Three Months Increases the Risk for Airway and Rhinitis Symptoms in Children A. Berner1, C. Bornehag1,2; 1Dep. of Pediatrics, Central Hospital, Karlstad, SWEDEN, 2University, Karlstad, SWEDEN. 994 Clinical Profile of Children Attending Asthma Camps M. J. Welch1, C. Archibald2, D. Larson3; 1Allergy and Asthma Medical Group and Research Center, San Diego, CA, 2U C San Diego School of Medicine, San Diego, CA, 3ALA of Minnesota, St. Paul, MN. 995 Ozone Induces Neutrophyl Inflammation in the Lower Airways D. Dokic1, P. Howarth2; 1Clinic of Pulmonology and Allergy, Skopje, THE FORMER YUGOSLAV REPUBLIC OF MACEDONIA, 2Southampton General Hospital, Southampton, UNITED KINGDOM. 996 Incidence and Potential Etiologies of Dysphonia in Patients With Allergies and/or Asthma R. C. Govindaiah, J. L. Baldwin, G. M. Sanders; Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, MI. 997 Specific Airway Conductance (SGaw) Reflecting Methacholine Responsiveness Is Associated With BMI M. E. Rose, M. S. Kavuru, A. L. Melton, Jr., K. McCarthy, D. M. Lang; Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH. 998 Maintenance Asthma Treatment With Fluticasone/Salmeterol Combination via Diskus: Effect on Outcomes in Inner City Children Enrolled in TennCare C. Stewart1, W. T. Nyuyen2, K. Fisher2, D. B. Lew2, E. Tolley2, T. Self2; 1LeBonheur Children’s Medical Center, Memphis, TN, 2University of Tennessee Health Science Center, Colleges of Medicine and Pharmacy, Memphis, TN. 999 Differences in Medication Compliance Among Elderly Patients With Asthma in Chicago C. A. Saltoun, R. E. Story, L. C. Grammer; Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL. 1000 Irreversible Lung Function Deficits in Young Adults With a History of Childhood Asthma

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S. L. Limb1, K. Brown1, R. G. Hamilton1, J. Tonascia2, R. Wise1, R. Wood3, N. F. Adkinson1; 1Asthma & Allergy Center, Johns Hopkins School of Medicine, Baltimore, MD, 2Department of Biostatistics, Bloomberg School of Public Health, Baltimore, MD, 3Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD. Increased Prevalence of Environmental Allergy in Patients With Crohn’s Disease M. L. Chudnow1, M. B. Levy1, K. J. Kelly1, D. G. Binion2; 1Allergy/Immunology, Medical College of Wisconsin, Milwaukee, WI, 2Gastroenterology, Medical College of Wisconsin, Milwaukee, WI. Can Total Control of Asthma Be Achieved? The Results of the GOAL Study R. Pauwels1, E. Bateman2, H. Boushey3, J. Bousquet4, W. Busse5, T. Clark6, S. Pedersen7; 1Department of Pulmonary Diseases, Ghent University Hospital, Ghent, BELGIUM, 2UCT Lung Institute, University of Cape Town, Cape Town, SOUTH AFRICA, 3University of California, San Francisco, CA, 4Hospital Arnaud De Villeneuve, Montpellier, FRANCE, 5University of Wisconsin Medical School, Madison, WI, 6National Heart and Lung Institute, Imperial College, London, UNITED KINGDOM, 7University of Southern Denmark, Kolding Hospital, Kolding, DENMARK. Variability in Asthma Severity/Control in Pediatric Asthma Patients Previously Receiving Short-Acting Beta2-Agonists B. Chipps1, L. Sutton2, A. Emmett2, P. Dorinsky2; 1Capital Allergy and Respiratory Diseases, Sacramento, CA, 2GlaxoSmithKline, Research Triangle Park, NC. Preventing False Spirometry Values and Invalid Symptom Scores in Respiratory Clinical Trials S. A. Raymond1, T. Blackadar2, W. Oueida3, N. E. Ohlenbusch2; 1Science and Research, PHT Corporation, and Harvard Medical School, Charlestown, MA, 2FitSense Inc, Boston, MA, 3PHT Corporation, Charlestown, MA. The Treatment of Hypertensive Asthmatic Subjects With Highly Selective β Blocker - Nebivolol J. Marczak; Pneumology and Alergology, Medical University of Lodz. Poland, Lodz, POLAND. No Evidence of Increased Sputum Eosinophilia in Treated Asthma Patients With Gastroesophageal Reflux V. Mehta1, A. Madaan2, C. K. Kim2, J. B. Hagan2; 1Division of General Internal Medicine, Mayo Clinic, Rochester, MN, 2Division of Allergic Diseases, Mayo Clinic, Rochester, MN. Persistent Asthma and Rhinitis Co-morbidity and Allergic Sensitization in a Sample of 317 Bulgarian Patients M. T. Staevska, D. N. Popova, M. A. Mandajieva, V. D. Dimitrov; Department of Allergology, Medical University - Sofia, Sofia, BULGARIA. Increased Sensitivity to IL-4 in Cystic Fibrosis Patients With Allergic Bronchopulmonary Aspergillosis J. Smick1, A. P. Knutsen1, P. S. Hutcheson1, V. P. Kurup2; 1Allergy/Immunology, Saint Louis University, St. Louis, MO, 2Allergy/Immunology, Medical College of Wisconsin, Milwaukee, WI. T Cell Cytokine Synthesis in Cystic Fibrosis Patients With Allergic Bronchopulmonary Aspergillosis A. P. Knutsen1, J. Smick1, P. S. Hutcheson1, V. P. Kurup2; 1Allergy/Immunology, Saint Louis University, St. Louis, MO, 2Allergy/Immunology, Medical College of Wisconsin, Milwaukee, WI. Sub-optimal Asthma Treatment and Symptom Control in Senior Citizens With a Diagnosis of Asthma R. E. Story, C. A. Saltoun, L. C. Grammer; Department of Medicine, Division of Allergy-Immunology, Northwestern University School of Medicine, Chicago, IL. Quantitative High Resolution CT Demonstrates Evidence for Peripheral Airway Disease in Asthmatic Children With Normal FEV1 N. Jain1, M. C. Gleason1, R. A. Covar1, J. D. Newell, Jr.2, E. W. Gelfand1, J. D. Spahn1; 1Department of Pediatrics, National Jewish

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Medical and Research Center, Denver, CO, 2Medical Imaging, National Jewish Medical and Research Center, Denver, CO. Symptom Variability in Children With Persistent Asthma: A Survey of Child Caregivers K. R. Murphy1, P. Marcus2, A. Rahman3, C. O’Brien3; 1Midwest Children’s Chest Physicians, Omaha, NE, 2New York College of Osteopathic Medicine, Old Westbury, NY, 3AstraZeneca, LP, Wilmington, DE. Assessing the Relative Contribution of the Asthma Control Test™ and Spirometry in Predicting Asthma Control C. A. Sorkness1, M. Schatz2, J. T. Li3, R. A. Nathan4, J. J. Murray5, P. Marcus6, M. Kosinski7, T. B. Pendergraft8, P. Jhingran8; 1University of Wisconsin, Madison, WI, 2Kaiser-Permanente Medical Center, San Diego, CA, 3Mayo Medical Center, Rochester, MN, 4Asthma and Allergy Associates, Colorado Springs, CO, 5Vanderbilt University Medical Center, Nashville, TN, 6New York College of Osteopathic Medicine, Old Westbury, NY, 7QualityMetric, Inc., Lincoln, RI, 8GlaxoSmithKline, Research Triangle Park, NC. Parental Positive Skin Test Is a Predictive Factor for Asthma in a Wheezing Infant A. Elizur1, Y. Kannai2, N. Pollack1, Y. Katz1; 1Pulmonary, Allergy & Immunology, Assaf Harofeh Hospital, Zerrifin, ISRAEL, 2Weizmann institute, Rehovot, ISRAEL. Role of Delayed Cellular Apoptosis in the Pathogenesis of Nasal Polyps S. S. Chao1, S. M. Graham1, C. L. Brown1, J. N. Kline2, I. Hussain3; 1Otolaryngology-Head & Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, 2Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 3Internal Medicine, Washington University, St Louis, MO. Bronchial Asthma and Atopic Dermatitis-Levels of Histamine and LTC4 J. Michalik1, J. Hofman2, T. Hofman2, A. M. Hofman2; 1Departmant of Animal Morphology, A. Mickiewicz University, Poznan, Poznan, POLAND, 2Center of Allergology, Poznan, POLAND. Dilated Cardiomyopathy With Mural Thrombus Presenting With Asthma-like Symptoms F. M. Tai, M. H. Serwonska; Allergy, Kaiser Permanente, South San Francisco, CA. Start Treatment With Appropriate Antibiotic Therapy (STAART) G. V. Doern1, P. B. Iannini2, D. P. Nicolau3; 1Clinical Microbiology, University of Iowa, Iowa City, IA, 2Department of Medicine, Danbury Hospital, Danbury, CT, 3Division of Infectious Diseases, Hartford Hospital, Hartford, CT. Real World Use and Impact of Desloratadine for Treatment of Allergy Symptoms D. Paradis; INFOMEDICS, Woburn, MA. Use of an Asthma Risk Questionnaire to Identify Young Children Likely to Benefit From Controller Therapy R. A. Covar1, J. D. Spahn1, S. Burson1, M. Gleason1, J. R. Murphy2, E. W. Gelfand1, & Children’s Medical Center3; 1Pediatrics, National Jewish Medical and Research Center, Denver, CO, 2Biostatistics, National Jewish Medical and Research Center, Denver, CO, 3Children’s Medical Center, Denver, CO. Use of Beta Blockers in Congestive Heart Failure Patients With Asthma and/or COPD P. L. G. Dinger1, J. Peters2, A. D. Galbreath3, P. B. Smith3, G. L. Freeman4; 1Internal Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX, 2Pulmonology, University of Texas Health Science Center San Antonio, San Antonio, TX, 3Disease Management Center, UTHSCSA/ALMVAH, San Antonio, TX, 4Cardiology, University of Texas Health Science Center San Antonio, San Antonio, TX. INS37217 Nasal Spray, a P2Y2 Receptor Agonist, as a Novel Treatment for Common Cold

TUESDAY

Abstracts S391

J ALLERGY CLIN IMMUNOL VOLUME 113, NUMBER 2

S392 Abstracts

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B. Winther1, D. Henry2, A. E. Schaberg3, K. L. Kuhn4, L. KeyesElstein5, D. J. Kellerman4, F. G. Hayden1; 1University of Virginia, Charlottesville, VA, 2Foothill Family Clinic, Salt Lake City, UT, 3Inspire Pharmaceuticals, Inc, Durham, NC, 4Inspire Pharmaceuticals, Inc., Durham, NC, 5Rho, Inc, Chapel Hill, NC. Asthma Symptoms in Early Childhood - What Happened Then? G. Wennergren, E. Goksör, M. Åmark, P. M. Gustafsson, B. Alm; Department of Pediatrics, Gothenburg University, Gothenburg, SWEDEN. Metal Working Fluids (MWF) and Microbial Contaminants Induce Hypersensitivity Pneumonitis in an Experimental Murine Model M. C. Zacharisen1, C. S. Barrios2, V. P. Kurup2, H. Choi3, J. N. Fink1, K. J. Kelly1; 1Pediatrics, Medical College of Wisconsin, Milwaukee, WI, 2Pediatrics, VA Research and Medical Center and Medical College of Wisconsin, Milwaukee, WI, 3Pathology, Medical College of Wisconsin, Milwaukee, WI. Effect of Mometasone Furoate Nasal Spray (MFNS) on Nasal Polyposis M. Bloom, H. Staudinger; Schering Plough Research Institute, Kenilworth, NJ. Sensitization to Inhalant and Food Allergens in Brazilian Children. Allergy Project – PROAL, Brazil M. C. Mallozi1, C. Naspitz2, D. Solé2, A. Zuliani3, T. Barba4, M. C. Aguiar5, P. S. Silva6, W. Rocha Filho7, N. Rosário8, J. Arruda9, E. Sarinho10, F. J. P. Soares11; 1Pediatrics/Division of Allergy and Clinical Immunology, Faculdade de Medicina do ABC, Santo André, BRAZIL, 2Pediatrics/Division of Allergy and Clinical Immunology, Federal University of São Paulo-Escola Paulista de Medicina, São Paulo, BRAZIL, 3Pediatrics/Division of Allergy and Clinical Immunology, Faculdade de Medicina de BotucatuUNESP, Botucatu, BRAZIL, 4Pediatrics/Division of Pneumology, Faculdade de Medicina de Catanduva, Catanduva, BRAZIL, 5Pediatrics/Division of Allergy and Clinical Immunology, Policlínica de Botafogo, Rio de Janeiro, BRAZIL, 6Pediatrics/Division of Allergy and Clinical Immunology, Hospital da Criança Santo Antônio, Porto Alegre, BRAZIL, 7Pediatrics/Division of Allergy and Clinical Immunology, Hospital Felício Roxo, Belo Horizonte, BRAZIL, 8Pediatrics/Division of Allergy and Clinical Immunology, Federal University of Paraná, Curitiba, BRAZIL, 9Pediatrics/Division of Allergy and Clinical Immunology, Hospital Albert Sabin, Fortaleza, BRAZIL, 10Pediatrics/Division of Allergy and Clinical Immunology, Federal University of Pernambuco, Recife, BRAZIL, 11Pediatrics/Division of Allergy and Clinical Immunology, Federal University of Alagoas, Maceió, BRAZIL. Phadiatop® in the Diagnosis of Respiratory Allergy in Children: Allergy Project – PROAL, Brazil C. K. Naspitz1, D. Solé1, B. A. Paes-Barreto2, C. A. M. Jacob3, E. C. S. Sarinho4, F. J. P. Soares5, L. S. Freitas6, L. K. P. Arruda7, M. C. Mallozi8, M. L. Chavarria9, M. M. S. Vilela10, N. A. Rosário11, N. F. Wandalsen8, V. M. Dantas12, W. Borges13; 1Pediatrics/Division of Allergy and Clinical Immunology, Federal University of São Paulo-Escola Paulista de Medicina, São Paulo, BRAZIL, 2Pediatrics/Division of Allergy and Clinical Immunology, Pará State University, Belém, BRAZIL, 3Pediatrics/Division of Allergy and Clinical Immunology, University of São Paulo, São Paulo, BRAZIL, 4Pediatrics/Division of Allergy and Clinical Immunology, Federal University of Pernambuco, Recife, BRAZIL, 5Pediatrics/Division of Allergy and Clinical Immunology, Federal University of Alagoas, Maceió, BRAZIL, 6Pediatrics/Division of Allergy and Clinical Immunology, Federal University of Bahia, Salvador, BRAZIL, 7Division of Allergy, Clinical Immunology and Rheumatology, University of São Paulo-Ribeirão Preto, Ribeirão Preto, BRAZIL, 8Pediatrics/Division of Allergy and Clinical Immunology, Faculdade de Medicina do ABC, Santo André,

J ALLERGY CLIN IMMUNOL FEBRUARY 2004

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BRAZIL, 9Division of Allergy and Clinical Immunology, Federal University of Goiás, Goiana, BRAZIL, 10Pediatrics/Division of Allergy and Clinical Immunology, State University of Campinas, Campinas, BRAZIL, 11Pediatrics/Division of Allergy and Clinical Immunology, Federal University of Parana, Curitiba, BRAZIL, 12Pediatrics/Division of Allergy and Clinical Immunology, Federal University of Rio Grande do Norte, Natal, BRAZIL, 13Pediatrics/Division of Allergy and Clinical Immunology, Hospital de Base, Brasília, BRAZIL. Prevalence of Asthma, Rhinoconjunctivitis and Atopic Eczema Among Brazilian Adolescents. Comparison Between ISAAC Phases I and III D. Solé1, I. C. C. Nunes1, N. A. Rosário2, L. S. Freitas3, M. Brito4, K. Melo1, R. Stein5, G. B. Fisher6, C. K. Naspitz1; 1Pediatrics/Division of Allergy and Clinical Immunology, Federal University of São Paulo-Escola Paulista de Medicina, São Paulo, BRAZIL, 2Pediatrics/Division of Allergy and Clinical Immunology, Federal University of Paraná, Curitiba, BRAZIL, 3Pediatrics/Division of Allergy and Clinical Immunology, Federal University of Bahia, Salvador, BRAZIL, 4Pediatrics/Division of Allergy and Clinical Immunology, Instituto Materno Infantil de Pernambuco, Recife, BRAZIL, 5Pediatrics/Division of Allergy and Clinical Immunology, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, BRAZIL, 6Pediatrics/Division of Allergy and Clinical Immunology, Federal University of Rio Grande do Sul, Porto Alegre, BRAZIL. Prevalence of Asthma, Rhinoconjunctivitis and Atopic Eczema Among Schoolchildren Living in the State of São Paulo, Brazil – ISAAC Phase III I. C. C. Nunes1, D. Solé1, A. C. Pastorino2, K. Melo1, C. Gonzales3, N. F. Wandalsen3, C. Leone2, C. K. Naspitz1; 1Pediatrics/Division of Allergy and Clinical Immunology, Federal University of São Paulo-Escola Paulista de Medicina, São Paulo, BRAZIL, 2Pediatrics/Division of Allergy and Clinical Immunology, University of São Paulo, São Paulo, BRAZIL, 3Pediatrics/Division of Allergy and Clinical Immunology, Faculdade de Medicina do ABC, Santo André, BRAZIL. Is That Lone Positive Skin Test to Mesquite for Real? J. M. Kelso; Allergy Division, Naval Medical Center, San Diego, CA. Comparative Analysis of the State of Asthma Prevalence in 014 Year-Old Children From Two Nation-Wide Surveys (Identical Cities) in 1990 and 2000 Y. Chen; the Capital Institute of Pediatrics, Beijing, CHINA. Environmental Tobacco Smoke Effects on Cysteinyl Leukotrienes in Respiratory Syncytial Virus Bronchiolitis B. H. Salt1, K. S. Kott1, J. N. Sakimura1, S. Jhawar1, R. J. McDonald1, L. J. Gershwin2, V. L. Mitchell2, J. P. Joad1; 1Pediatrics, University of California, Davis, Sacramento, CA, 2Veterinary Medicine, Department of Pathology, Microbiology, and Immunology, University of California, Davis, Davis, CA. Association Between Rhinitis, Asthma and Major Illness D. Wang1, M. Raza1, C. Heng2, Y. Chan3; 1Otolaryngology, National University of Singapore, Singapore, SINGAPORE, 2Pediatrics, National University of Singapore, Singapore, SINGAPORE, 3Clinical Trial & Epidemiology Research Unit, Singapore, SINGAPORE. Interleukin-4 Receptor α (IL-4Rα) Gene Polymorphisms and Increased IL-4 Stimulated CD23 Expression on B-Cells in Cystic Fibrosis (CF) Patients With Allergic Bronchopulmonary Aspergillosis (ABPA) M. R. Warrier, J. K. Smick, B. Chauhan, A. K. Chauhan, A. P. Knutsen; Allergy & Immunology, Saint Louis University, St. Louis, MO. Sneezing, Sniffling, Scratching or Snoring, What Is Worse for Allergic Children in Singapore

Abstracts S393

J ALLERGY CLIN IMMUNOL VOLUME 113, NUMBER 2

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Poster Session 5403 Tuesday, March 23 11:00 AM to 12:00 PM Immunodiagnostics 1049 Simultaneous Quantitative Measurement of IgG Antibodies to Streptococcus Pneumoniae Serotypes by Microsphere Photometry G. Jacob, H. Homburger; Mayo Clinic, Rochester, MN. 1050 Concentration of LTC4 and Histamine in Serum and IgG Against Candida albicans A. M. Hofman1, T. Hofman1, J. Hofman1, J. Michalik2; 1Center of Allergology, Poznan, POLAND, 2University of A. Mickiewicz, Poznan, POLAND. 1051 Diagnosis of Fungal Allergy: Comparison of Detection of Allergens From Germinating Fungi (Halogen Method) With Pharmacia UniCap Assay and Skin Prick Tests B. J. Green1,2, E. Yli-Panula1, J. K. Sercombe3, E. R. Tovey2,3;

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1Faculty of Medicine, The University of Sydney, Sydney, AUSTRALIA, 2Cooperative Research Centre for Asthma, Sydney, AUSTRALIA, 3Woolcock Institute of Medical Research, Sydney, AUSTRALIA. A Novel Metalloproteinase, Leukolysin, and Development of a Standardized Immunoassay J. B. Sweet1, C. Liebeler1, J. Nie2, D. Pei2, M. N. Blumenthal1; 1Medicine, U of MN, Minneapolis, MN, 2Pharmacology, U of MN, Minneapolis, MN. Interference of Xolair (Anti-Human IgE) in Serological Assays for Total and Allergen Specific IgE R. G. Hamilton, C. Rossi, S. S. Saini; Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD. Measurement of Pro-inflammatory and Anti-inflammatory Cytokines in Exhaled Breath Condensates P. F. Kao, C. L. Liebeler, M. N. Blumenthal; Pulmonary, Allergy and Critical Care, University of Minnesota, Minneapolis, MN. Inter-Laboratory Reproducibility and Inter-Assay Correlation of the Turbo-MP™ Radioimmunoassay for Quantitative Measurement of Allergen-Specific immunoglobulin E D. Davoudzadeh1, A. Chen1, A. Valcour2, K. J. Kontis1; 1Research & Development, Hycor Biomedical Inc., Garden Grove, CA, 2Center for Esoteric Testing, Laboratory Corporation of America, Burlington, NC. Skin Reactivity to Histamine in Atopic Children in Singapore, Influence of Specific Sensitizations Y. See1, M. Iancovici Kidon1, A. Goh1, O. Chay1, A. Balakrishnan2; 1Paediatric Medicine, KK Children’s Hospital, Singapore, SINGAPORE, 2Otolaryngology, KK Children’s Hospital, Singapore, SINGAPORE. CD45RA/CD45R0 a Probable Marker for Future Development of Allergy? K. Stencel-Gabriel, K. Stencel-Gabriel; 3rd Clinic of Pediatrics, Chorzow, POLAND.

Poster Session 5404 Tuesday, March 23 11:00 AM to 12:00 PM Vaccines 1059 Dose Effect of Mucosal Adjuvant LT(R192G) on the Induction of Th1 and Th2 Immunity D. Q. Tran1, C. S. Baliga2, M. C. Hart2, S. E. Pacheco2; 1Pediatrics, Baylor College of Medicine, Houston, TX, 2Allergy and Immunology, Baylor College of Medicine, Houston, TX. 1060 Commercial Immune Globulin, Intravenous (IGIV) Products Contain Anti-Vaccinia Antibodies J. C. Goldsmith1, N. Eller2, H. Golding2, D. E. Scott2; 1Immune Deficiency Foundation, Towson, MD, 2US Food and Drug Administration, Bethesda, MD. 1061 Intratracheal Instillation of r Alt a2 DNA Vaccine Is Detectable in Bronchoalveolar Lavage Fluid After 2 Weeks H. Sanchez1, R. K. Bush2; 1Research, William S Middleton Veterans Memorial Hospital, Madison, WI, 2Allergy Immunology/Research, University of Wisconsin/William S Middleton Veterans Memorial Hospital, Madison, WI. 1062 Oral Antigen Delivery of Varying Doses of Soluble or Particulate Antigens in the Presence of Adjuvant Selectively Induces Th1 or Th2 Responses in Systemic and Mucosal Compartments C. S. Baliga1, M. C. Hart1, C. Lamblin1, S. S. Krater2, M. K. Estes2, S. E. Pacheco1; 1Pediatric Allergy and Immunology, Baylor College of Medicine, Houston, TX, 2Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX.

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M. Iancovici Kidon1, Y. See1, A. Goh1, O. Chay1, A. Balakrishnan2; 1Paediatric Medicine, KK Children’s Hospital, Singapore, SINGAPORE, 2Otolaryngology, KK Children’s Hospital, Singapore, SINGAPORE. Demographics and Outcomes of a School-Based Breathmobile Program in Orange County, CA O. Liao, S. Galant; CHOC Breathmobile, Orange, CA. A Randomized Trial Comparing Peak Expiratory Flow Versus Symptom Self-Management Plans for Children With Persistent Asthma K. Letz, W. Smits; The Allergy and Asthma Center, Fort Wayne, IN. Allergenicity of Recombinant Bet v1 and Art v1 Evaluated by Nasal Provocation D. O. Harder1, D. Holzmann2, K. Blaser3, R. Crameri3, P. Schmid-Grendelmeier1; 1Allergy Unit, Dept. of Dermatology, University Hospital Zurich, Zurich, SWITZERLAND, 2Ear, Nose and Throat Unit, University Hospital Zurich, Zurich, SWITZERLAND, 3Dept. of Molecular Allergy, Swiss Institute for Allergy & Asthma Research SIAF, Davos, SWITZERLAND. Impact of Asthma on Working Caregivers: Productivity and Disease Management L. Hu1, J. Slezak2, J. Berger3, L. Fensterheim4, W. Faust5, N. Stine6; 1Analytics and Outcomes, CareMark Inc, Northbrook, IL, 2Hewitt Associates, LLC, Lincolnshire, IL, 3Clinical Quality and Support, Caremark Inc, Northbrook, IL, 4Analytics and Outcomes, Caremark Inc, Northbrook, IL, 5SAT Carecenter, Caremark Inc, San Antonio, TX, 6Disease Mangagement, Caremark Inc, Northbrook, IL. Risk Factors for Frequent Emergency Department Visits Among Children With Asthma G. E. Eroglu1, A. Tugaeon2, A. K. Ozturk3; 1Allergy, Immunology & Asthma, Tulane University, Kenner, LA, 2Internal Medicine, Louisiana State University Medical School, New Orleans, LA, 33rd Year Student, Yale Medical School, New Haven, CT. Preliminary Safety and Efficacy of Daclizumab in the Treatment of Patients With Moderate to Severe Chronic Persistent Asthma W. W. Busse1, J. W. Baker2, B. L. Charous3, P. Chervinsky4, K. T. Kim5, G. N. Gross6, P. E. Korenblat7, R. S. Shames8; 1Medicine/Allergy and Immunology, University of Wisconsin Medical School, Madison, WI, 2Allergy Associates, Portland, OR, 3Milwaukee Medical Clinic, Milwaukee, WI, 4New England Clinical Studies, North Dartmouth, MA, 5Allergy/Asthma/Resp. Care Med Ctr, Newport Beach, CA, 6Dallas Allergy & Asthma Center, Dallas, TX, 7Associated Specialists In Medicine, St. Louis, MO, 8Protein Design Labs, Inc., Fremont, CA.

S394 Abstracts

J ALLERGY CLIN IMMUNOL FEBRUARY 2004

1063 C-Reactive Protein and Vaccinia Specific Lymphocyte Proliferative Responses Following Smallpox Immunization M. R. Nelson1, D. M. Koelle2, R. L. Davis3, C. B. Wilson4, R. J. Engler1; 1Dept Allergy-Immunology, Walter Reed Army Medical Center, Washington, DC, 2Dept Allergy & Infectious Disease, University of Washington, Seattle, WA, 3Dept Pediatrics, University of Washington, Washington, WA, 4Dept Immunology, University of Washington, Seattle, WA. 1064 Enhanced Systemic and Mucosal Immune Responses in Mice Immunized With Recombinant Bacillus anthracis Protective Antigen (rPA) Using a Novel Nanoemulsion Adjuvant J. R. Baker, Jr., A. Bielinska, J. Landers, K. Janczak, P. Cao; University of Michigan, Ann Arbor, MI. 1065 The Immune Response to Conjugated Meningococcal C Vaccine in Oncology Patients J. Yu1, S. Reiter1, P. Kavan1, J. Reichman1, A. Borkowski2, B. Mazer1; 1Divison of Allergy and Immunology and Pediatric Hematology and Oncology, Montreal Children’s Hospital, Montreal, PQ, CANADA, 2Chiron Behring, Marburg, GERMANY. 1066 An Active-Duty Man Who Was Coincidentally Diagnosed With Osteosarcoma Two Weeks After Smallpox Vaccination A. G. Letz1, R. W. McFarland2, J. P. Dice3; 1Internal Medicine, Wilford Hall USAF Medical Center, San Antonio, TX, 2Hematology/Oncology, Wilford Hall USAF Medical Center, San Antonio, TX, 3Allergy/Immunology, Wilford Hall USAF Medical Center, San Antonio, TX. 1067 Prevention and Monitoring of Adverse Events Following Immunization (AEFI) via a Specialized Counseling Center: A Model of Surveillance G. Zanoni, T. Nguyen, G. Tridente; Department of Pathology Immunology Section, University of Verona, Verona, ITALY. 1068 A Case of Rheumatoid Arthritis and Anthrax Vaccination M. Vasudev1, M. Zacharisen2; 1Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, 2Asthma and Allergy Center, Children’s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI.

Poster Session 5405 Tuesday, March 23 11:00 AM to 12:00 PM

TUESDAY

Dermatologic and Ocular Diseases Case Reports 1069 Atypical Presentation of Henoch-Schonlein Purpura: Case Report and Review of the Literature J. L. Rubin1,2, J. Moy1,3; 1Allergy/Immunology, Rush-Presbyterian-St. Luke’s Medical Center, Chicago, IL, 2Microbiology/Immunology, Rush-Presbyterian-St. Luke’s Medical Center, Chicago, IL, 3Pediatrics, Cook County Hospital, Chicago, IL. 1070 Case Report: An Unusual Presentation of Atopic Dermatitis in an Elderly Female W. Mak, B. A. Silverman, A. T. Schneider; Dept. of Allergy Immunology, Long Island College Hospital, Brooklyn, NY. 1071 Allergy to Turnip Greens J. Martín-Lázaro1, Á. Rico-Díaz1, A. Argüelles1, M. CastroMurga1, I. Rodríguez-Zuazo1, M. Ferreiro-Arias1, B. Bartolomé2; 1Allergy, Juan Canalejo Hospital, La Coruna, SPAIN, 2R&d, BialArístegui Laboratories, Bilbao, SPAIN. 1072 Itching Nodules and Aluminium Allergy Induced by Vaccination With Adsorbed Vaccines E. Bergfors1, B. Trollfors2, A. Inerot3; 1Dpt of Primary Health Care, Göteborg University, Göteborg, SWEDEN, 2Dpt of Pediatrics, Göteborg University, Göteborg, SWEDEN, 3Dpt of Dermatology, Göteborg University, Göteborg, SWEDEN. 1073 Erythropoetic Protoporphyria Presenting as “Solar Urticaria”

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S. Siddiqi, B. Kaplan; North Shore-Long Island Jewish Health Care System, New Hyde Park, NY. Three Week Old Male Infant Presents With Epidermolysis Bullosa and Eosinophilic Colitis R. P. Rucker, J. Sleasman, N. Tangsinmankong; Division Allergy and Immunology, All Children’s Hopsital, St Petersburg, FL. Nephrogenic Fibrosing Dermopathy: A Unique Fibrosing Skin Condition of Renal Insufficiency Associated With CD34/Procollagen Dual Positive Circulating Fibrocytes C. A. Irani1, S. E. Cowper2, G. Aftimos3, A. Barbari4; 1Internal Medicine, Allergy/Immunology Section, Hotel Dieu de France, Beirut, LEBANON, 2Dermatology and Pathology, Yale University School of Medicine, New Haven, CT, 3Institut National de pathologie, Beirut, LEBANON, 4Internal Medicine, Nephrology Section, Rizk Hospital, Beirut, LEBANON. Contact Dermatoconjunctivitis Secondary to Phenylephrine Hydrochloride Ophthalmic Solution M. A. Cavuoto1, S. J. Weiss1, I. J. Salzman2; 1Allergy/Immunology, North Shore Long Island Jewish Health System, New Hyde Park, NY, 2Ophthalmology, Long Island Eye Care L.L.P., Hicksville, New York, NY. Vasculitis and CD 19 Plasma Cells: Is It a Reactive Process or a Plasma Cell Dyscrasia? P. A. Takach1, M. Golightly2, R. Dattwyler1; 1Division of Allergy and Clinical Immunology, State University of New York Stony Brook, Stony Brook, NY, 2Immunology Laboratory, State University of New York Stony Brook, Stony Brook, NY.

Poster Session 5406 Tuesday, March 23 11:00 AM to 12:00 PM Atopic Dermatitis: Clinical Aspects 1078 Prevalence of Eczema Symptoms in the Second Year of Life T. N. Tan1, D. L. C. Lim1, Y. S. Chong2, B. W. Lee1, H. P. S. van Bever1; 1Department of Paediatrics, National University of Singapore, Singapore, SINGAPORE, 2Department of Obstetrics and Gynaecology, National University of Singapore, Singapore, SINGAPORE. 1079 Prevalence of Atopic Eczema and the Relating Factors of Eczema Among 6-7 Yr-Old Schoolchildren in Denizli, Turkey A. Akcay1, E. Dagdeviren1, M. Zencir2, U. Ones3, N. Guler3, Z. Tamay3; 1Pamukkale Medical School, Department of Pediatrics, Denizli, TURKEY, 2Department of Public Health, Pamukkale Medical School, Denizli, TURKEY, 3Department of Allergy and Chest Disease, Istanbul Medical School, Department of Pediatrics, Istanbul, TURKEY. 1080 Relationship of Pet Exposure and Atopic Dermatitis (AD) in the Childhood Allergy Study (CAS) A. J. Davis1, E. M. Zoratti1, S. L. Havstad1, C. C. Johnson1, D. R. Ownby2; 1Allergy, Henry Ford Health Systems, Detroit, MI, 2Allergy, Medical College of Georgia, Augusta, GA. 1081 House Dust Mites on the Skin and Clothes of Atopic Dermatitis Patients V. Teplitsky1, K. Y. Mumcouglu2, I. Dalal1, E. Somekh1, A. Tanay1; 1Allergy/Immunology Unit, Wolfson Medical Center, Tel Aviv University, Holon, ISRAEL, 2Department of Parasitology, Hebrew University-Hadassah Medical School, Jerusalem, ISRAEL. 1082 Differences in Itch Perception Between Atopic Eczema and Chronic Urticaria U. Darsow1,2, E. Ripphoff1,2, J. Ring1,2; 1Dept. of Dermatology and Allergy, TU Munich, Munich, GERMANY, 2Div. of Environmental Dermatology and Allergy GSF/TUM, Munich, Center for Allergy and Environment, Munich, GERMANY.

1083 Relations Between Perception and Pain Threshold Levels in Patients With Atopic Dermatitis M. Worm; Dept. of Dermatology and Allergy; Charite, Berlin, GERMANY. 1084 The Diagnostic Value of Atopy Patch Test (APT) With Regard to Late-Phase Clinical Reactions to Food in Children With Atopic Dermatitis (AD) R. Tesse, V. L. Miniello, P. Fiermonte, C. Massagli, F. Fiore, M. Mastronardi, L. Armenio, L. Brunetti; Department of Pediatrics, University of Bari, Bari, ITALY. 1085 Eyelash Length in Children and Adolescents With Allergic Diseases N. Segal1, Y. Levy1, D. Ben-Amitai2, Y. L. Danon1; 1Kipper Institute of Immunology, Schneider Children Medical Center, Petah Tikva, ISRAEL, 2Dermatology Unit, Schneider Children Medical Center, Petah Tikva, ISRAEL.

Poster Session 5407 Tuesday, March 23 11:00 AM to 12:00 PM Recent Advances in Allergen Proteomics 1086 Expression of Recombinant Bla g 7 in Pichia pastoris and Comparison of IgE Reactivity With Native Counterpart K. Jeong1, J. Lee2, I. Lee2, C. Hong3, H. Ree2, T. Yong1; 1Dept. of Parasitology and Institute of Tropical Medicine, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA, 2Dept. of Parasitology and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA, 3Dept. of Internal Medicine and Institute of Allergy, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA. 1087 Cloning and Analysis of Mono-Specific scFv Fragments From Chicken to Allergenic Proteins of Periplaneta americana (American Cockroach) N. deVore, W. Finlay, E. Dobrovolskia, A. Gam, J. Slater; Food and Drug Administration, Rockville, MD. 1088 IgE Epitope Mapping of Pen ch 13 Allergen H. Shen1, H. Lai1, M. Tam2, H. Chou1, H. Tai1; 1Dept. of Medical Research, Veterans General Hospital-Taipei, Taipei, TAIWAN REPUBLIC OF CHINA, 2Institute of Molecular Biology, Academia Sinica, Taipei, TAIWAN REPUBLIC OF CHINA. 1089 Gohieria fusca (GF) and Chortoglyphus arcuatus (CA): Allergenic Properties of Two Mite Species H. Muesken1, J. T. Franz2, A. R. R. Heutelbeck3, T. Schulz3, P. Tuchola3, U. Schlensog4, E. Hallier3, K. C. Bergmann1; 1Allergy and Asthma Clinic, Bad Lippspringe, GERMANY, 2University of Paderborn, Paderborn, GERMANY, 3Georg-August-University, Göttingen, GERMANY, 4Hycor Biomedical, Kassel, GERMANY. 1090 Expression and Purification of Recombinant Pru p 3 and Mal d 3 in Escherichia coli R. Schwarz1, M. Wallner1, R. van Ree2, L. Zuidmeer2, F. Ferreira1, N. Wopfner1; 1Department of Genetics and General Biology, University Salzburg, Salzburg, AUSTRIA, 2Department of Immunopathology, Sanquin Research at CLB, Amsterdam, NETHERLANDS. 1091 Cross Reactivity Between Rat and Mouse Urinary Allergens M. Jones, H. Jeal, A. Newman Taylor; Department of Occupational and Environmental Medicine, Imperial College @ NHLI, London, UNITED KINGDOM. 1092 Isoelectrophoretic Patterns of Der p 2 Isoforms in House Dust From Different Homes R. B. Gore, L. Curbishley, A. Custovic, A. Woodcock; North West Lung Centre, Wythenshawe Hospital, Manchester, UNITED KINGDOM.

1093 Histamine Releasing Factor (TCTP) Is an Auto-Reactive IgEBinding Antigen in Patients Allergic to Cladosporium herbarum C. Holler1, B. Simon-Nobbe1, V. Wally1, R. Crameri2, K. Richter1, A. Hartl3, J. Thalhamer3, C. Ebner4; 1Genetic, University of Salzburg, Austria, Salzburg, AUSTRIA, 2Swiss Institute of Allergy and Asthma Research (SIAF), Davos, SWITZERLAND, 3Biochemistry, University of Salzburg, Austria, Salzburg, AUSTRIA, 4Institute of General and Experimental Pathology, AKH, University of Vienna, Vienna, AUSTRIA. 1094 Molecular Cloning and Characterization of an Allergen From Persian Melon A. Varasteh, M. Sankian, M. Mahmoudi; Mashhad University of Medical Sciences, Immunology Research Center, Mashhad, IRAN (ISLAMIC REPUBLIC OF). 1095 Art v 1 Isoforms: Cloning, E.coli Expression and Immunological Analysis A. Dedic1, R. Bauer2, A. Hartl2, R. Van Ree3, J. Thalhamer2, C. Ebner4, F. Ferreira1; 1Institute of Genetics, University of Salzburg, Salzburg, AUSTRIA, 2Institute of Biochemistry, University of Salzburg, Salzburg, AUSTRIA, 3Department of Allergy, CLB, Amsterdam, NETHERLANDS, 4Department of Pathophysiology, University of Vienna, AKH-3Q, Vienna, AUSTRIA. 1096 Hev b 9, the Latex Enolase, a Necessary Reagent of a Mold Allergy Diagnostic Panel? S. Wagner1, A. Mari2, B. Simon-Nobbe3, B. Wagner1, B. Niggemann4, M. Breitenbach3, O. Scheiner1, H. Breiteneder1; 1Dept. of Pathophysiology, University of Vienna, Vienna, AUSTRIA, 2Allergy Unit, National Health Service, Rome, ITALY, 3Institute of Genetics and General Biology, University of Salzburg, Salzburg, AUSTRIA, 4University Children’s Hospital Charite, Humboldt University, Berlin, GERMANY. 1097 Production of Recombinant Single-Chain Fv Antibody Fragments Specific for the Hydroxyproline-Rich Domain of Natural Art v 1 by Phage Display P. Gruber1, A. Dedic1, G. Gadermaier1, S. Wagner2, H. Breiteneder2, F. Ferreira1; 1Institute of Genetics and General Biology, University of Salzburg, Salzburg, AUSTRIA, 2Institute of Pathophysiology, University of Vienna, Vienna, AUSTRIA. 1098 Art v 1, the Major Mugwort Allergen, Cross-Reacts With Proteins Originating From Compositae and Grass Pollen M. Egger1, N. Wopfner1, M. Himly1, A. Dedic1, R. Bauer2, A. Mari3, R. van Ree4, A. Hartl2, J. Thalhamer2, F. Ferreira1; 1Institute of Genetics and General Biology, University of Salzburg, Salzburg, AUSTRIA, 2Institute of Chemistry and Biochemistry, University of Salzburg, Salzburg, AUSTRIA, 3Allergy Unit, National Health Service, Rome, ITALY, 4Department of Immunopathology, Sanquin Research at CLB, Amsterdam, NETHERLANDS. 1099 Isolation and Characterization of the Major Allergen From Italian Cypress (Cupressus sempervirens) Pollen A. Togawa1, R. C. Panzani2, M. Garza1, R. M. Goldblum1, T. Midoro-Horiuti1; 1Child Health Research Center, University of Texas Medical Branch, Galveston, TX, 2Laboratoire de Recherches, Marseille, FRANCE. 1100 A Novel Two EF-Hand Ca2+-Binding Allergen From Ragweed Pollen N. Wopfner1, P. Gruber1, R. van Ree2, A. Mari3, F. Ferreira1; 1Department of Genetics, University of Salzburg, Salzburg, AUSTRIA, 2Department of Immunopathology, Sanquin Research at CLB, Amsterdam, NETHERLANDS, 3Allergy Unit, Rome, ITALY. 1102 The Impact of Allergenic Molecules in Clinical Allergy. How Far Is the “Bench” From the “Bed”? A 35-Year Retrospective Analysis of Papers From International Scientific Journals A. Mari1,2, V. Mari1, A. Ronconi1; 1Allergy Data Laboratories, Latina, ITALY, 2Allergy Unit, National Health Service, Rome, ITALY.

TUESDAY

Abstracts S395

J ALLERGY CLIN IMMUNOL VOLUME 113, NUMBER 2

S396 Abstracts

J ALLERGY CLIN IMMUNOL FEBRUARY 2004

1103 The Allergome Web Site - A Database of Allergenic Molecules. Aim, Structure, and Data of a Web-Based Resource A. Mari1,2, D. Riccioli3; 1Allergy Data Laboratories, Latina, ITALY, 2Allergy Unit, National Health Service, Rome, ITALY, 3Panservice, Latina, ITALY.

Poster Session

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5408 Tuesday, March 23 11:00 AM to 12:00 PM

TUESDAY

Risk Factors for Asthma 1104 Asthma Phenotypes in US Children: Findings From the Third National Health and Nutrition Examination Survey C. F. Kelley, D. M. Mannino, D. M. Homa, A. Savage-Brown, F. Holguin; National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA. 1105 The Role of Childhood Asthma in Altering Parental Smoking Behavior J. J. Liem1, A. L. Kozyrskyj2, A. B. Becker1; 1Pediatric Allergy and Clinical Immunology, University of Manitoba, Winnipeg, MB, CANADA, 2Community Health Sciences, University of Manitoba, Winnipeg, MB, CANADA. 1106 Interaction Between Sex and Age in the Prevalence of Current Asthma S. J. Arbes, Jr.1, X. Guo2, J. Orelien2, D. C. Zeldin1; 1NIEHS/NIH, Research Triangle Park, NC, 2Constella Group, Durham, NC. 1107 Short-Term Impact of a Multi-Faceted Intervention for Wheezy Infants at Risk for Asthma M. D. Klinnert1, A. H. Liu1, M. Price1, M. C. Ellison2, N. Budhiraja1; 1Pediatrics, National Jewish Medical and Research Center, Denver, CO, 2Biostatistics, National Jewish Medical and Research Center, Denver, CO. 1108 Contamination of Nebulizers With Environmental Allergens M. E. Bollinger1, A. Butz2, R. G. Hamilton3; 1Pediatrics, University of Maryland School of Medicine, Baltimore, MD, 2Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, 3Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD. 1109 Frequency of IgE-Mediated Respiratory Diseases in Type 1 Diabetes Mellitus (DM1) M. Malucelli, N. A. Rosario, C. A. Riedi, M. B. Ribeiro; Pediatrics, University of Parana, Curitiba, BRAZIL. 1110 Clinical Deterioration in Pediatric Asthma Patients Living Near the World Trade Center After 9/11/01 A. M. Szema1, M. Khedkar1, P. Maloney1, M. S. Mickels1, H. Patel1, F. Modugno2, A. Tso3, D. Lin3; 1SUNY Stony Brook School of Medicine, Stony Brook, NY, 2University of Pittsburgh, Pittsburgh, PA, 3Charles B. Wang Community Health Center, New York, NY. 1111 Increased Dietary Beta-Carotene Intake Associated With Better Asthma Quality of Life A. Moreira1, P. Moreira2, J. Fonseca1, F. Pereira2, I. Campos2, L. Granja2, L. Matos2, M. Sousa2, J. Rodrigues1, M. Vaz1; 1Unidade de Imunoalergologia, Porto, PORTUGAL, 2University of Porto, Faculty of Nutrition and Food Sciences, Porto, PORTUGAL. 1112 Prevalence of Symptoms Related to Asthma and Indoor Environmental Factors in Santander City, Spain V. de Benito, J. Soto; Ciencias Médicas, Santander Medical School, Santander, SPAIN. 1113 House Dust Endotoxin Exposure Mitigates Asthma Severity in a Tropical Environment A. Zambelli-Weiner1, M. Stockton1, E. Ehrlich1, M. Whitmer2, D. Lewis2, S. Olenchock2, K. C. Barnes1; 1Allergy & Clinical Immunology, Johns Hopkins School of Medicine, Baltimore, MD,

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2National Institute of Occupational Safety and Health, Morgantown, WV. Delayed DTP Immunizations and the Risk for Pediatric Atopy and Asthma C. C. Johnson1, D. R. Ownby2, E. L. Peterson1, S. H. Alford1, S. L. Havstad1, E. M. Zoratti1, C. L. Joseph1; 1Henry Ford Health System, Detroit, MI, 2Medical College of Georgia, Augusta, GA. Environmental Factors and Quality of Life Among Poor Children With Asthma S. R. Weiss1, P. K. Singhal1, F. G. Pradel1, H. R. Rubin2, I. H. Zuckerman1, M. E. Bollinger3, C. J. Blaisdell3, B. Stuart1; 1Pharmaceutical Health Services Research, University of Maryland, Baltimore, MD, 2The Johns Hopkins University, Baltimore, MD, 3Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD. Respiratory Symptoms, Subjective Annoyance and Asthma in a Moisture Damaged Central Hospital T. M. Husman; Department of Environmental Health, National Public Health Institute, Kuopio, FINLAND. Symptom Triggers in an Adolescent Asthma Population G. Pyrgos1, E. Horowitz2, D. Joyner2, F. Malveaux3, A. Togias2; 1Johns Hopkins Bayview Medical Center, Baltimore, MD, 2Clinical Immunology, Johns Hopkins University, Baltimore, MD, 3Howard University College of Medicine, Washington, DC. Predicting Pediatric Asthma Admissions for Barbados E. Blades1, D. Kimes2, E. Levine2, G. Mathison1, H. Thani3, M. Lavoie1; 1Biological and Chemical Sciences, University of the West Indies, Bridgetown, BARBADOS, 2Goddard Space Flight Center, NASA, Maryland, WA, 3University of the West Indies, Queen Elizabeth Hospital, Bridgetown, BARBADOS. Study of Prevalence Rate of Childhood Asthma Rhinitis and Eczema in Serbia and Montenegro Z. M. Zivkovic; Asthma Center, Center for Paediatric Pulmonology, Belgrade, YUGOSLAVIA. Prevalence Of Symptoms Suggestive of Asthma in Age School Children; In Chiclayo Peru F. V. Maticorena Agramonte1, P. Chiarella2, L. Vega Briceño2; 1Pediatrics, Hospital Belen, Lambayeque, PERU, 2Pediatrics, Hospital Cayetano Heredia, Lima, PERU. Skin Test Sensitivity to 5 Different Cockroach Species in Patients With Allergic Respiratory Diseases in Rosario, Argentina L. Ardusso1, J. Molinas1, L. Nardone1, S. Crisci1, E. FernándezCaldas2, I. Molinari1, J. Galymany3, J. Carnes2, C. Crisci1; 1Department of Allergy and Immunology, University of Rosario, Rosario, ARGENTINA, 2R & D Department, C.B.F. LETI, S.A., Tres Cantos, SPAIN, 3Department of Allergy and Immunology, Sanatorio Británico, Rosario, ARGENTINA. Changes in Wheal Size to Grass, Cat, and Mite Allergens During Adolescence in Males and Females P. Mandhane1, J. M. Greene1, J. O. Cowan2, D. R. Taylor2, M. R. Sears1; 1McMaster University, Hamilton, ON, CANADA, 2University of Otago, Dunedin, NEW ZEALAND. Prediction of Asthma Admission Using the Newly Developed Siriraj Clinical Asthma Score (SCAS) Compared to Wood’s and Parkin’s Score D. Chaidaroon, N. Reinmanee, O. Jirapongsananuruk, N. Visitsunthron, P. Vichyanond; Pediatrics, Siriraj Hospital, Bangkok, THAILAND. Rural-Urban Differences in Asthma Prevalence: Possible Explanations A. L. Kozyrskyj1, A. B. Becker2; 1Community Health Sciences, Pharmacy, University of Manitoba, Winnipeg, MB, CANADA, 2Pediatric Allergy and Clinical Immunology, University of Manitoba, Winnipeg, MB, CANADA. Irradiation as a Hazard for Mucociliary Clearance

J. Foltinová1, A. Schrott-Fischer2, V. Z˘ ilínek3, W. Freysinger2, V. Foltin4; 1Histology and Embryology, Comenius University, Bratislava, SLOVAKIA, 2Clinic of Otorhinolaryngology, University of Innsbruck, Innsbruck, AUSTRIA, 3Pediatric Clinic, Comenius University, Bratislava, SLOVAKIA, 4Department of Plasma Physics, Comenius University, Bratislava, SLOVAKIA. 1126 Differences in Asthma Risk Factors Due to Influences of Acculturation in a Birth Cohort of New York City-Born Puerto Ricans G. L. Chew1, L. M. Acosta1, D. Acevedo-García2, D. E. Cortés3, A. Divjan1, J. C. Correa1, J. K. Fagan1, R. B. Mellins1, M. S. Perzanowski1; 1Columbia University, New York, NY, 2Health and Social Behavior, Harvard School of Public Health, Boston, MA, 3Psychiatry, Harvard Medical School, Cambridge, MA. 1127 Polymorphisms in Pulmonary Surfactant Protein A1 (SP-A1) and A2 (SP-A2) Genes and Susceptibility to High Altitude Pulmonary Edema (HAPE) S. Saxena1, R. Kumar2, T. Madan1, V. Gupta2, K. Muralidhar3, P. U. Sarma1; 1Molecular Biochemistry and Diagnostics Division, Institute of Genomics and Integrative Biology, Delhi, INDIA, 2Defence Institute of Physiology and Allied Sciences, Delhi, INDIA, 3Department of Zoology, University of Delhi, Delhi, INDIA. 1128 Dramatic Increase in the Prevalence of Allergic Sensitization in Japanese Adults Born After the 1950s M. Shinohara1, H. Saito1,2, K. Matsumoto1,2; 1Department of Allergy and Immunology, National Research Institute for Child Health and Development, Setagaya-ku, JAPAN, 2Laboratory for Allergy Transcriptome, RIKEN Research Center for Allergy and Immunology, Yokohama, JAPAN.

Poster Session 5409 Tuesday, March 23 11:00 AM to 12:00 PM Adverse Reactions to Drugs and Biologicals II 1129 Status Asthmaticus in Children of Innercity: Findings of a Retrospective Study G. E. Eroglu1, F. Sulun2, A. K. Ozturk3; 1Allergy, Immunology & Asthma, Tulane University, Kenner, LA, 2Allergy, Immunology & Asthma, Gulhane Medical School, Istanbul, TURKEY, 33rd Year Student, Yale Medical School, New Haven, CT. 1130 Cytological Changes in Nasal Secretion After Intranasal Aspirin Challenge in Subjects With Aspirin Hypersensitivity P. Kuna, I. R. Kuprys´, M. Kupczyk, B. Kuzminska, P. Górski; Pneumonology and Allergy, Medical University of Lodz, Lodz, POLAND. 1131 Chemotherapy Anaphylaxis: Case Reports and Retrospective Analysis S. I. Hungness1, H. Qawi1, P. Khosla1, A. Gewurz2; 1Internal Medicine, Rush University Medical Center, Chicago, IL, 2Immunology/Microbiology, Rush University Medical Center, Chicago, IL. 1132 Anaphylaxis Following Cystoscopy Caused by Cidex®-OPA (Ortho-Phthalaldehyde) Cold Sterilization Solution W. N. Sokol; Medicine, University of California Irvine, Newport Beach, CA. 1133 IgE-Mediated Anaphylaxis to Viscotoxins of Mistletoe (Viscum album) Extracts C. Bauer, T. Oppel, B. Przybilla, F. Ruëff; Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, München, GERMANY. 1134 Life Threatening Anaphylactoid Reaction to Celecoxib R. Dworski1, J. W. Thomas2; 1Allergy, Pulmonary & Critical Care, Vanderbilt University, Nashville, TN, 2Rheumatology, Vanderbilt University, Nashville, TN.

1135 Drug Rash With Eosinophilia and Systemic Symptoms (DRESS) Secondary to Anti-Tuberculosis Therapy With Features of Isoniazid Toxicity A. M. Ditto, R. E. Story; Allergy-Immunology, Northwestern University, Chicago, IL. 1136 Delayed Cutaneous Eruption to Platinum Salts Chemotherapy M. Calvo1, M. De Barrio1, J. Sainz1, S. Infante1, P. Tornero1, M. Lecona2, T. Herrero1; 1Allergy, Hospital General Universitario Gregorio Marañon, Madrid, SPAIN, 2Anathomopathology, Hospital General Universitario Gregorio Marañon, Madrid, SPAIN. 1137 Tolerance Induction to Rofecoxib in a Patient With Bartter’s Syndrome D. Schiavino, E. Nucera, A. Buonomo, C. Roncallo, T. De Pasquale, C. Lombardo, L. Giuliani, C. Alonzi, G. Altomonte, V. Pecora, E. Pollastrini, G. Patriarca; Department of Allergology, Università Cattolica del Sacro Cuore, Rome, ITALY. 1138 Allergy to Isosulfan Blue E. Tsai1, J. Tencati1, W. Chen1, H. Song1, D. Jerome2; 1UCI Medical Center, Orange, CA, 2Long Beach Veterans Administration Medical Center, Long Beach, CA. 1139 Successful Intravenous Desensitization of Paclitaxel and Cisplatin in Adult Ovarian Cancer Patients With Prior Anaphylactic Reactions B. Wong1, P. Shuen2; 1Clinical Immunology, Department of Internal Medicine, North York General Hospital, University of Toronto, North York, ON, CANADA, 2Department of Obstetrics and Gynecology, North York General Hospital, University of Toronto, North York, ON, CANADA. 1140 Recurrent Idiopathic Anaphylaxis Linked to Pantoprazole A. P. Kollmeier1, J. Eddleston2, B. L. Zuraw2, S. C. Christiansen3; 1Department of Allergy and Immunology, Scripps Clinic, La Jolla, CA, 2Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 3Department of Allergy and Immunology, Kaiser Permanente, San Diego, CA. 1141 Two Cases of Ortho-Phthalaldehyde Induced Allergic Reactions in Patients Undergoing Surveillance Cystoscopy S. N. Joshi, S. Rosenfeld; Allergy/Immunology/Rheumatology, University of Rochester Medical Center, Rochester, NY. 1142 Aspirin Sensitivity Asthma and Platelet Function L. Palma-Carlos; CHIUL, CHIUL - Centro Hematologia Imunolog.Univ.Lisboa, PORTUGAL. 1143 Anaphylaxis to FEIBA With Successful Desensitization: Case Report K. Siripassorn, H. Chantaphakul; Divi of Allergy and Clin Immunol, Chulalongkorn University, Bangkok, THAILAND. 1144 Successful Intrathecal Administration of Methotrexate Following a Prior Adverse Reaction to Intravenous Methotrexate D. R. McDonald, M. J. Dorsey, A. Dioun; Immunology, Children’s Hospital, Boston, Boston, MA. 1145 Cefepime Desensitization in a Patient With Cystic Fibrosis D. Damin, S. Marney, D. DiPersio, F. Hargrove; Vanderbilt University Medical Center, Nashville, TN. 1146 Stevens-Johnson Syndrome Developing in a Girl With Minimal Change Nephrotic Syndrome on Deflazacort Therapy W. Kim1, E. Kim1, H. Lee1, J. Jeong1, S. Nahm2; 1Internal Medicine, Ilsan Paik Hospital, Kyungki-do, REPUBLIC OF KOREA, 2Pediatrics, Ilsan Paik Hospital, Kyungki-do, REPUBLIC OF KOREA. 1147 Cross-Reactivity Between Rofecoxib and Naproxen Y. Nofech-Mozes, D. B. Hummel; Division of Immunology and Allergy, Hospital for Sick Children, Toronto, ON, CANADA. 1148 Reinstitution of Methotrexate Despite History of Erythema Multiforme and Angioedema D. F. Soteres1, J. M. El-Dahr2; 1Allergy, Immunology, and Rheumatology, Tulane Health Sciences Center, New Orleans, LA, 2Pediatric Allergy, Immunolgy, and Rheumatology, Tulane Health Sciences Center, New Orleans, LA.

TUESDAY

Abstracts S397

J ALLERGY CLIN IMMUNOL VOLUME 113, NUMBER 2

S398 Abstracts

J ALLERGY CLIN IMMUNOL FEBRUARY 2004

1149 Tetracaine Challenge Test in a Multiple Local Anesthetics Sensitive Patient H. Chantaphakul, K. Siripassorn, K. Ruxrungtham; Internal Medicine Department, Allergy/Immunology Division, Chulalongkorn University Hospital, Bangkok, THAILAND. 1150 Potential Adverse Reaction From Complementary and Alternative Medicines (CAM) Containing Pharmaceutical Products (PP) H. C. G. Wong; Divison of Allergy & Immunology, University of British Columbia, Vancouver, BC, CANADA. 1151 Subcutaneous Nodules as an Adverse Reaction to Injections of Low-Molecular-Weight Calcium Containing Heparins: Calcinosis of the Cutis and Subcutis N. Hunzelmann1, K. Scharffetter-Kochanek2, T. Krieg1, D. Eich1; 1Dermatology, University of Cologne, Cologne, GERMANY, 2Dermatology, University of Ulm, Ulm, GERMANY. 1152 Acute Generalized Exanthemous Pustulosis (AGEP) With Aromatase Inhibitor (Exemestane) M. Gupta1, M. Vasudev1, S. Thumma1, S. Marks1, Y. Wang2, L. Blust3, P. Hari3, M. Zacharisen4; 1Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, 2Dermatology, Medical College of Wisconsin, Milwaukee, WI, 3Neoplastic Diseases and Related Disorders, Medical College of Wisconsin, Milwaukee, WI, 4Allergy and Immunology, Medical College of Wisconsin, Milwaukee, WI. 1153 Delayed Hipersensitivity to Lidocaine G. Rubio, A. Garcia, R. Gonzalez, M. C. Dieguez, M. Anton, P. Berges, B. De La Hoz; Allergy, Hospital Ramon Y Cajal, Madrid, SPAIN. 1154 Acetylsalicylic Acid Applied to Patients Suffering From Bronchial Asthma S. M. S. Genova1, E. S. Genova2; 1Clinical Center of Allergology, Medical University, Sofia, BULGARIA, 2Faculty of Medicine, Eberhard Karls Universit, Tubingen, GERMANY. 1155 Management of the Multiple Drug Allergy Syndrome - Case Report P. C. C. Pinto, L. M. Borrego, C. N. Braga, T. Almeida, J. E. Rosado-Pinto; Immunoallergy, D. Estefânia Hospital, Lisbon, PORTUGAL.

Poster Session 5410 Tuesday, March 23 11:00 AM to 12:00 PM

TUESDAY

Food Hypersensitivity III 1156 The Characters of Sensitization to Egg White, Cow’s Milk, Soybean in Korean Children With Atopic Dermatitis and Acute Urticaria J. Jung1, K. Ahn2, S. Lee2; 1Department of Pediatrics, Dong-A University Hospital, Busan, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA, 2Department of Pediatrics, Samsung Seoul Hospital, Seoul, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA. 1157 Preservative Free Diet (PFD) Improves Chronic Urticaria & Angioedema (CUA) Liliane Gendreau-Reid, md, Victoria, Ca L. M. F. Gendreau-Reid; Peds, UBC, Victoria, BC, CANADA. 1158 Cross-Linking of Peanut Allergens by Polyphenol Oxidase and Its Effect on Peanut Allergenicity S. Chung, E. T. Champagne; USDA-ARS, New Orleans, LA. 1159 Validity of the Diagnostic Tests in Egg Allergy M. C. Diéguez, M. Antón, E. Camacho, D. Prieto, I. Herranz, M. Cuevas, B. De La Hoz; Allergy, Ramon Y Cajal Hospital, Madrid, SPAIN. 1160 Monosensitization to Coconut E. Martin, P. Tornero, M. De Barrio, C. I. Pérez, J. M. Beitia, M. L. Baeza; Allergy, H.G.U. Gregorio Marañon, Madrid, SPAIN.

1161 Positive Skin Prick Tests in Patients With and Without Clinical Manifestations to Peanuts V. P. Hernandez-Trujillo, M. S. Blaiss; University of Tennessee Memphis, Cordova, TN. 1162 Lingonberry Allergy Y. Barrios1, V. Matheu2, B. de la Parte3, M. Fernández3, J. M. Zubeldia3, M. L. Baeza3; 1Immunology, Hospital Universitario de Canarias, La Laguna, SPAIN, 2Lund University, Lund, SWEDEN, 3Allergy, Hospital Gregrorio Marañon, Madrid, SPAIN. 1163 A Case of Beer and Wheat Allergy M. Antón, M. Diéguez, A. García, G. Rubio, M. Díez; Allergy, Ramon Y Cajal Hospital, Madrid, SPAIN. 1164 Rice Enterocolitis With Growth Hormone Deficiency P. Suntipraron, P. Chatchatee, J. Ngamphaiboon; Division of Allergy and Clinical Immunology, Department of Pediatrics, King Chulalongkorn Memorial Hospital, Bangkok, THAILAND. 1165 Treatment of Allergic Esophagitis With Budesonide Turbuhaler K. A. DeMuth, D. Mitchell, A. Irani; Pediatrics, Virginia Commonwealth University Health Systems, Richmond, VA. 1166 First Known Report of Food Hypersensitivity or Atopy in a Person With the Prader-Willi Syndrome B. A. Becker, B. Y. Whitman; Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO. 1167 Measurements of Serum Specific IgE Antibody to Fish Roe and Mollusks in Children With Seafood Allergy R. Shibata, S. Nishima; Department of Pediatrics, National Minami Fukuoka Hospital, Fukuoka, JAPAN. 1168 Wheat Allergy in a Child Casting Doubt on Celiac Disease in Mother D. de Boissieu, C. Dupont; St Vincent de Paul Hospital, Paris, FRANCE. 1169 Severe Hypersensitivity Reaction to Total Parenteral Nutrition in a Newborn: A Case Report G. Beaulieu, E. Ferretti; CHUS, Fleurimont, PQ, CANADA. 1170 Anisakis simplex (A.s.) Induced Acute Pancreatitis and Hepatic Involvement in Gastroallergic Anisakiasis F. F. Vega de la Osada, A. Daschner; Sección de Alergia, Hospital Universitario La Princesa, Madrid, SPAIN. 1171 A Case of Anaphylaxis to Curry Powder in Childhood L. Ju Suk1, A. Kang-Mo2, L. Sang-Il3; 1Pediatric allergy, Masan Samsung Hospital, Masan, REPUBLIC OF KOREA, 2Pediatirc allergy, Samsung Medical Center, Seoul, REPUBLIC OF KOREA, 3Pediatric allergy, Samsung Medical Center, Seoul, REPUBLIC OF KOREA. 1172 Case Report: An Adult Onset of Cow’s Milk Hypersensitive S. Wong; A. Nayak, MD, Normal, IL. 1173 Food Dependent Exercise Induced Anaphylaxis Caused by Cauliflower: First Case Report in China J. Yin, H. Li; Department of Allergy, Peking Union Medical College Hospital, Beijing, CHINA. 1174 To Read Food Material Labeling, It Is Important to Understand Cross-Reactivity of IgE Antibody A. Akasawa1, K. Tanaka2, K. Akashi2, H. Kawahara1, T. Suda2, I. Nomura2, Y. Ohya2, T. Kamiya1, K. Matsumoto2, H. Saito2; 1Department of Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, JAPAN, 2Department of Allergy, National Center for Child Health and Development, Tokyo, JAPAN. 1175 Clinical Significance Antigen-Specific IgG4 for the Diagnosis of Food Allergy in Atopic Dermatitis: The Comparison of Serum Antigen-Specific IgE and IgG4 Levels With the Results of DBPCFC for Milk and Egg White J. Oh1, H. Ahn2, K. Ryu3, G. Noh4; 1Pediatrics, Hanyang University Kuri Hospital, Guri, Kyonggi-Do, REPUBLIC OF KOREA, 2Proteomix, Seoul Allergy Research Institute, Food BioTech

Abstracts S399

J ALLERGY CLIN IMMUNOL VOLUME 113, NUMBER 2

Poster Session 5411 Tuesday, March 23 11:00 AM to 12:00 PM Prevalence of Allergic Disease and Access to Care 1176 Less “Respect”: Ratings of Inpatient Care by HIV/AIDS Patients R. J. Wolosin; Research and Development, Press Ganey Associates, Inc, South Bend, IN. 1177 Rule of Four J. R. Claflin; Oklahoma Allergy and Asthma Clinic, Oklahoma City, OK. 1178 The Hospitalization Rate of Asthma Attach in Pediatric Emergency Department of Six Year Interval D. U. Altıntas, T. Celik, U. Celik, M. Yilmaz, G. B. Karakoc, S. G. Kendirli, H. L. Yılmaz; Pediatric Allergy and Immunology, Cukurova University, Adana, TURKEY. 1179 Improving Appointment Availability in the Allergy Department During the High-Demand Season M. H. Serwonska, F. M. Tai, S. Huling, Z. Puckett; Allergy, Kaiser Permanente, South San Francisco, CA. 1180 The AH! Asthma Health Clinical Practice Collaborative: A Model to Improve Asthma Care P. S. Roderick1, J. L. Osgood2, L. Letourneau2, D. Deatrick2, B. A. Chilmonczyk3, V. W. Rogers4, R. J. Vosmus4; 1Pediatrics, MaineHealth/Maine Medical Center, Portland, ME, 2MaineHealth, Portland, ME, 3Pediatrics, Asthma Allergy Associates, Portland, ME, 4Pediatrics, Maine Medical Center, Portland, ME. 1181 Epidemiological Characterization of Patients with Persistent Rhinitis. Immunologic Outpatient Clinic. Clinical Immunology Research Unit. University of Carabobo. Valencia. Venezuela M. Petrola1, M. E. Flores, Sr.1, A. Torres, II2, M. Pacheco, III2, L. Castro2; 1Immunology Unit, University of Carabobo, Valencia, VENEZUELA, 2Immunology Unit, INSALUD, Valencia, VENEZUELA. 1182 Validation of Electronic Versus Paper Subject Diaries M. D. Kelly, D. Y. Young, N. M. Lane, R. S. Shames; Protein Design Labs, Inc., Fremont, CA. 1183 Assessment of Access to Specialized Asthma Care in the Third World Country of St. Vincent and the Grenadines S. Ellis1, H. Bacchus1, C. D. Schwindt2; 1Medicine, Milton Cato Memorial Hospital, Kingstown, SAINT VINCENT AND THE GRENADINES, 2Pediatrics, UCI, Orange, CA. 1184 Herbal and Alternative Medication Use for the Treatment of Asthma in St. Vincent and the Grenadines H. Bacchus1, C. D. Schwindt2; 1Medicine, Milton Cato Memorial Hospital, Kingstown, SAINT VINCENT AND THE GRENADINES, 2Pediatrics, CHOC/UCI, Orange, CA. 1185 The Prevalence of Asthma and Allergic Rhinitis Among Adults in St. Petersburg, Russia A. Emelyanov, G. Fedoseev, G. Sergeeva, N. Ivanova, T. Zibrina, I. Zukanova, I. Maxi-menko; Pavlov Medical University, St. Petersburg, RUSSIAN FEDERATION. 1186 Profile of Pollen Allergy in Hungarian Children Having Respiratory Allergic Diseases Between 1992 and 2000 L. Endre1, L. Soti2, L. M. DuBuske3; 1Central Hospital of MAV, Budapest, HUNGARY, 2Outpatient Clinic of MAV, Szombathely, HUNGARY, 3Immunology Research Institute of New England, Fitchburg, MA.

1187 The Prevalence of Allergic Diseases Among Health Care Workers (HCW) in the South of Russia R. Khanferyan1, V. V. Grigorieva1, T. V. Sundatova1, S. V. Reuk1, L. M. DuBuske2; 1Institute of Allergy & Asthma, Krasnodar, RUSSIAN FEDERATION, 2Immunology Research Institute of New England, Fitchburg, MA. 1188 The Significance of Allergic Family History and Cord BloodImmunoglobulin E as a Predictor of the Development of Allergic Diseases in Later Life H. H. Kim, M. Lee, J. Kim, J. Lee; Dept. of Pediatrics, Holy Family hospital, The Catholic University of Korea, Pucheon-Si, REPUBLIC OF KOREA.

Poster Session 5412 Tuesday, March 23 11:00 AM to 12:00 PM Mechanism of Allergic Inflammation 1189 Costimulatory Molecules CD80/CD86 and OX40L Are Upregulated in a Murine Model of Allergic Aspergillosis C. S. Barrios1, B. D. Johnson2, J. D. Henderson, Jr.3, J. N. Fink1, K. J. Kelly1, V. P. Kurup1,4; 1Pediatrics/Allergy, Medical College Of Wisconsin, Milwaukee, WI, 2Pediatrics/Hematology-Oncology, Medical College Of Wisconsin, Milwaukee, WI, 3Surgery, Medical College Of Wisconsin, Milwaukee, WI, 4Research Service, VA Medical Center, Milwaukee, WI. 1190 Fluticasone Propionate Increases Suppression of Allergen-Driven T Cell Proliferation by CD4+CD25+ T Cells D. S. Robinson, D. Nguyen; Allergy and Leukocyte Biology, Imperial College London, London, UNITED KINGDOM. 1191 Delineation of Low Affinity IgE Receptor b (CD23b) Signaling Events P. Matangkasombut1,2, S. B. Gauld3, J. C. Cambier3, L. J. Rosenwasser1; 1Allergy/Clinical Immunology, National Jewish Medical and Research Center, Denver, CO, 2Microbiology and Immunology, Faculty of Science, Mahidol University, Bangkok, THAILAND, 3Immunology, National Jewish Medical and Research Center, Denver, CO. 1192 A Signal Pathway in the Production of Inflammatory Cytokines by Reactive Oxygen Species Generated From PMAStimulated HMC-1 J. Kim1, B. Lee2, J. Ro1; 1Department of Pharmacology, Sungkyunkwan University School of Medicine, Suwon, REPUBLIC OF KOREA, 2Department of Microbiology, College of medicine Yonsei University, Seoul, REPUBLIC OF KOREA. 1193 Mast Cells Express Multiple Regulator of G Protein Signaling (RGS) Proteins G. Bansal1, S. Rao2, K. Nocka2, K. Druey1; 1Lab of Allergic Diseases, NIAID, Rockville, MD, 2UCB Research Inc./UCB Pharma, Cambridge, MA. 1194 Control of IgE and Allergy-Related Th1 and Th2 Cytokines by PG102, a Water-Soluble Extract From Actinidia sp E. Park1, B. Kim2, H. Jong2, M. Son3, S. Kim1, M. Jin2; 1School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul, REPUBLIC OF KOREA, 2Pangenomics Co. Ltd., Seoul, REPUBLIC OF KOREA, 3Dong-A. Co. Ltd., Seoul, REPUBLIC OF KOREA. 1195 Treatment With Flt3-Ligand Secreting Plasmid Reverses Allergic Airway Inflammation in Asthma J. H. Edwan1,2, D. K. Agrawal1,2; 1Medical Microbiology and Immunology, Creighton University, Omaha, NE, 2Center for Allergy, Asthma and Immunology, Creighton University, Omaha, NE. 1196 The Effect of CpG-Oligodeoxynucleotides With Different Backbone Structures and 3’ Hexameric Deoxyriboguanosine Run Conjugation on the Treatment of Asthma in Mice

TUESDAY

Co.Ltd, Seoul, REPUBLIC OF KOREA, 3Div. of Medical Device Standards, Medical Devices & Radiation Health, Korea Food & Drug Administration, Seoul, REPUBLIC OF KOREA, 4Allergy & Clinical Immunology, Seoul Allergy Clinic, Seoul, REPUBLIC OF KOREA.

S400 Abstracts

1197

1198

1199

1200

1201

1202

1203

J ALLERGY CLIN IMMUNOL FEBRUARY 2004

Y. Chang1,2, Y. Kim2,3, T. Kim2,3, H. Park2,3, H. Kang2,3, S. Kim2,3, J. Bahn3, K. Min2,3, Y. Kim2,3, S. Cho2,3; 1Medicine, Seoul National University Bundang Hospital, Seoung Nam Si, Gyeonggi-do, REPUBLIC OF KOREA, 2Internal Medicine, Seoul National University College of Medicine, Seoul, REPUBLIC OF KOREA, 3Internal Medicine, Seoul National University Hospital, Seoul, REPUBLIC OF KOREA. Outside-in Signaling in Airway Epithelial Cells M. Ulanova1, L. Puttagunta2, A. D. Schreiber3, A. D. Befus1; 1Pulmonary Research Group, University of Alberta, Edmonton, AB, CANADA, 2Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, CANADA, 3Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA. Activation of ERK1 and ERK2 in Human Eosinophils Is Regulated by Cholesterol: Relevance to IL-5 Signal Transduction M. Bates, R. Heuser, H. Haglund, P. J. Bertics; Biomolecular Chemistry, University of Wisconsin, Madison, WI. VLA-4 Antagonist WAY160103 (WAY) Inhibits VCAM-1 Activated Eosinophil (EOS) Respiratory Burst but Promotes Eosinophil Derived Neurotoxin (EDN) Degranulation A. M. Brooks1, J. B. Sedgwick1, K. J. Jansen1, H. Kita2, D. Squillace3, J. D. Kennedy4, W. W. Busse1; 1Medicine, University of Wisconsin, Madison, WI, 2Mayo Clinc, Rochester, MN, 3Mayo Clinic, Rochester, MN, 4Wyeth Research, Princeton, NJ. IL-13 Signaling in Cells Stably Expressing FLAG-Human IL13R Alpha 2 M. O. Daines, S. Basu, G. K. Khurana Hershey; Pediatric Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. Chitosan Nanoparticle-Mediated De Novo Synthesis of a Novel Natriuretic Hormone Peptide Reverses Established Asthma in Mice R. V. Singam1,2, X. Kong1,2, G. Hellerman1,2, H. San Juan1, S. Behera1, W. Zhang1, P. K. Jena1, R. F. Lockey1,2, S. S. Mohapatra1,2; 1Dept. of Internal Medicine, Div. of Allergy and Immunology, University of South Florida, Tampa, FL, 2VA Hospital, Tampa, FL. Generation of Heat-Killed E. coli Expressing Cow Milk Proteins for Immunotherapy Regiment for the Milk Allergic Mice A. Grishin, K. Srivastava, H. Sampson, X. Li; Pediatrics, The Mount Sinai School of Medicine, New York, NY. Plasma Concentration of Interleukin-18 in Acute Myocardial Infarction P. P. Oransky1, R. A. Khanferyan1, L. M. DuBuske2, S. P. Oransky1; 1Institute of Allergy and Asthma, Krasnodar, RUSSIAN FEDERATION, 2Immunology Research Institute of New England, Fitchburg, MA.

Poster Session

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1207

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1210

1211

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5413 Tuesday, March 23 11:00 AM to 12:00 PM

TUESDAY

Genomics/Proteomics/Others 1204 The Evaluation of Toll-like Receptor 9 (TLR9) as a Susceptibility Gene for Atopy and Asthma M. Singla1, T. D. Howard2, N. Reijmerink3, M. J. Basehore2, D. A. Meyers2, D. S. Postma4, E. R. Bleecker2; 1Program on Allergy and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC, 2Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, 3University Hospital, Groningen, NETHERLANDS, 4Department of Pulmonology, University Hospital, Groningen, NETHERLANDS. 1205 Gene Expression Profiles in Human Nasal Polyp Tissues Studied by DNA Microarray Z. Liu1, B. S. Bochner1, J. P. Sypek2, I. Wang2, F. G. Oppenheim3,

1214

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J. Kim1; 1Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Ctr, Baltimore, MD, 2Metabolic & Respiratory Diseases, Wyeth Discovery Research, Cambridge, MA, 3Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA. Allergen Induces Heavy-Chain Class Switching to IgE in the Nasal Mucosa of Hay Fever Patients P. Takhar1, H. A. Coker1, L. Smurthwaite1, D. Fear1, S. R. Durham2, H. J. Gould1; 1The Randall Centre, King’s College London, London, UNITED KINGDOM, 2Upper Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, UNITED KINGDOM. Polymorphism C371T Results in Resistance of CD23 to Enzymatic Cleavage in Cultured Cells J. Meng, L. Cao, G. Lu, J. Poole, C. Bates, L. J. Rosenwasser; NJMRC, Denver, CO. PKC Inhibitor Reduces Airway Inflammation and Hyperresponsiveness by Reducing MMP-9 Expression K. S. Park1, Y. C. Lee2; 1Pediatrics, Presbyterian Medical Center, Chonju, REPUBLIC OF KOREA, 2Internal Medicine, Chonbuk National University, Chonju, REPUBLIC OF KOREA. Anti-Angiogenic Therapy Prevents the Development of Asthma Y. Suzaki1, K. Hamada1, K. Miyamoto1, T. Ito1, M. Sho2, H. Kimura1; 1Second Department of Internal Medicine, Nara Medical University, Kashihara City, JAPAN, 2First Department of Surgery, Nara Medical University, Kashihara City, JAPAN. MCP-1 Gene Regulatory Region Polymorphism in Chinese Children With Mild, Moderate and Near-Fatal Asthma T. C. Yao1,2, M. L. Kuo3, J. L. Huang1; 1Department of Pediatrics, Chang Gung Children’s Hospital, Taoyuan, TAIWAN REPUBLIC OF CHINA, 2Graduate Institute of Clinical Medical Science, Chang Gung University, Taoyuan, TAIWAN REPUBLIC OF CHINA, 3Department of Microbiology and Immunology, Chang Gung University, Taoyuan, TAIWAN REPUBLIC OF CHINA. Well-Differentiated Systemic Mastocytosis: A New Disease Variant With Mature Mast Cell Phenotype and Lack of Codon 816 c-Kit Mutations C. Akin1, L. Escribano2, R. Nuñez2, A. Garcia-Montero3, M. Angulo3, A. Orfao3, D. D. Metcalfe1; 1Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 2Unidad de Mastocitosis, Servicio de Hematología, Hospital Ramón y Cajal, Madrid, SPAIN, 3Servicio General de Citometria, Centro de Investigación del Cáncer, Universidad de Salamanca, Salamanca, SPAIN. Association Studies of STAT6 Gene Polymorphisms and Asthma in a Mulatto Population L. Caraballo, B. Martinez, S. Jiménez, D. Mercado, C. Vergara; Institute for Immunological Research, University of Cartagena, Cartagena, COLOMBIA. Capillary Blood Derived Allergy Diagnostic in Children With Bronchial Asthma and Seasonal Allergic Rhinitis Using CHIP Technology J. M. Baron1, H. Ott2, R. Heise1, C. M. Schroeder1, G. Heimann2, H. F. Merk1; 1Dept of Dermatology, RWTH Aachen, Aachen, GERMANY, 2Dept of Pediatrics, RWTH Aachen, Aachen, GERMANY. Increased Biological Activity of IL-13.Q130, a Naturally Occurring Variant of Human IL-13, in Primary Human Cells F. Vladich, S. Brazille, R. Ghittoni, D. Vercelli; Funcitional Genomics Laboratory, Arizona Respiratory Center, University of Arizona, Tucson, AZ. Immunoglobulin A (IgA) in Allergic Airway Disease E. E. Fouda; AlAzhar University Center for Immunology & Allergic Diseases, Cairo, EGYPT. The Effects of Olopatadine, Desloratadine, Ketotifen, Azelastine, and Epinastine on Membrane Stability

Abstracts S401

J ALLERGY CLIN IMMUNOL VOLUME 113, NUMBER 2

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Oral Abstract Session 5601 Tuesday, March 23 1:30 PM to 2:45 PM Microorganisms and Asthma 1:30 1223 Transcriptional Profiling of Nasal Epithelium During Natural Colds in Asthmatic Subjects P. C. Avila, G. Dolganov, S. Donnelly, T. Ward, H. Wong, P. Cadbury, H. A. Boushey; Medicine, UCSF, San Francisco, CA. 1:45 1224 The Relationship Between Early Fever and Allergic Sensitization at Age 6 to 7 Years L. Williams1, E. L. Peterson2, D. R. Ownby3, C. C. Johnson2; 1Department of Internal Medicine, Henry Ford Health System, Detroit, MI, 2Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI, 3Department of Pediatrics, Medical College of Georgia, Detroit, MI.

2:00 1225 Inhibition of Respiratory Syncytial Virus Replication by Vector-Derived Small Interfering RNAs Against NS1 Protein W. Zhang1,2, H. Yang1, H. San Juan1,2, R. Singam1,2, X. Kong1,2, G. Hellerman1, R. F. Lockey1,2, M. E. Peeples3, S. S. Mohapatra1,2; 1Dept. of Internal Medicine, Div. of Allergy and Immunology, University of South Florida, Tampa, FL, 2VA Hospital, Tampa, FL, 3Rush Medical College, Chicago, IL. 2:15 1226 Increased Frequency and Severity of Viral Infections During Infancy Is Associated With Recurrent Wheezing in the First Three Years of Life D. F. G. Da Silva1, K. A. Roberg1, C. J. Tisler1, E. L. Anderson1, H. J. Hiemke1, T. E. Pappas1, P. A. Shult2, C. J. Kirk2, R. E. Gangnon3, Z. Li3, M. D. Evans3, J. E. Gern1, R. F. Lemanske, Jr.1; 1Department of Pediatrics, University of Wisconsin - Madison, Madison, WI, 2Microbiology Division, University of Wisconsin Madison, Madison, WI, 3Biostatistics and Medical Informatics, University of Wisconsin - Madison, Madison, WI. 2:30 1227 RSV-Induced Cytokine Response Patterns in Cord Blood and Clinical Manifestations of RSV Infections in the First Year of Life C. C. Copenhaver1, J. E. Gern1, P. Shultt2, R. Gagnon3, Z. Li3, K. Roberg1, C. Tisler1, D. DaSilva1, R. F. Lemanske, Jr.4; 1Department of Pediatrics, University of Wisconsin, Madison, Madison, WI, 2State Laboratory of Hygiene, Madison, WI, 3Biostatistics and Medical Informatics, University of Wisconsin, Madison, Madison, WI, 4Departments of Pediatrics and Medicine, University of Wisconsin, Madison, Madison, WI.

Oral Abstract Session 5602 Tuesday, March 23 1:30 PM to 2:45 PM Treatment and Immunopathogenesis of Rhinosinusitis 1:30 1228 Treatment of Chronic Rhinosinusitis With Intranasal Amphotericin B: A Prospective, Randomized, Placebo-Controlled Trial D. A. Sherris1, J. U. Ponikau2, A. Weaver3, E. Frigas4, H. Kita5; 1Otolaryngology, State University of New York at Buffalo, Buffalo, NY, 2Otolaryngology, Mayo Clinic, Rochester, MN, 3Biostatistics, Mayo Clinic, Rochester, MN, 4Allergy and Immunology, Mayo Clinic, Rochester, MN, 5Allergy and Immunology and Otolaryngology, Mayo Clinic, Rochester, MN. 1:45 1229 Differential Expression of Matrix Metalloproteinase 2 and 9 in the Allergic Nasal Mucosa and Nasal Polyps R. Pawankar, S. Watanabe, M. Nonaka, C. Ozu, M. Aida, T. Yagi; Otolaryngology, Nippon Medical School, Tokyo, JAPAN. 2:00 1230 Gene Microarray Analysis of CD4-Positive T Cells in Chronic Rhinosinusitis (CRS) L. J. B. Davis1, J. Ponikau2, D. A. Sherris2, D. A. Plager3, H. Kita1; 1Division of Allergic Diseases, Mayo Clinic, Rochester, MN, 2Department of Otorhinolaryngology, Mayo Clinic, Rochester, MN, 3Division of Dermatology, Mayo Clinic, Rochester, MN. 2:15 1231 Odorant Receptor Polymorphisms in Patients With Non-Allergic Vasomotor Rhinitis J. A. Bernstein1, L. Jin2, D. W. Nebert2; 1Internal Medicine, University of Cincinnati, Cincinnati, OH, 2Environmental Health, University of Cincinnati, Cincinnati, OH.

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G. Graff1, S. T. Miller1, J. M. Yanni1, M. M. Momsen2, H. L. Brockman2; 1Ophthalmology Research, Alcon Research, Ltd, Fort Worth, TX, 2The Hormel Institute, University of Minnesota, Austin, MN. Aachen Atopy Array: A Novel Allergen Chip Technique for the Analysis of Serum IgE Antibodies to Recombinant Latex Allergens C. M. Schroeder1, H. Ott2, H. F. Merk1, J. M. Baron1; 1Dept. of Dermatology, RWTH Aachen, Aachen, GERMANY, 2Dept. of Pediatrics, RWTH Aachen, Aachen, GERMANY. A Genome Scan of Asthma Phenotypes in a Large Collection of Families From Europe Australia and US S. G. Pillai1, C. Mathias2, R. Lam3, M. Blumenthal4, M. Wagner1, M. Ehm1, W. Anderson1, S. Brewster5, J. Vestbo6, J. Riley2, Investigators-GAIN-Network7; 1Genetics Research, Glaxo SmithKline, Research Triangle Park, NC, 2Genetics Research, Glaxo SmithKline, Stevenage, UNITED KINGDOM, 3Genetics Research, Glaxo SmithKline, Upper Providence, PA, 4University of Minnesota, Minneapolis, MN, 5Genetics Research, Glaxo SmithKline, Greenford, UNITED KINGDOM, 6Hvidovre University Hospital, Hvidovre, DENMARK, 7NC. Family History and Allergic Phenotypes: Data From the Childhood Allergy Study (CAS) M. J. Maliarik1, S. Havstad1, D. R. Ownby2, C. C. Johnson1; 1Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI, 2Pediatrics, Medical College of Georgia, Augusta, GA. Candidate Serum Biomarkers for Predictive Medicine and Disease Management of Asthma J. Just1, C. Chavany2, K. D. Yamaguchi2, S. Chen2, S. R. Schramm2, F. Sahraoui1, A. Grimfeld1, M. Jendoubi2; 1Service de Pneumo-Allergologie Pediatrique, Hopital Armand Trousseau, Paris, FRANCE, 2Milagen, Inc., Richmond, CA. Newly Found Mutations of C1 Esterase Inhibitor Gene in Three Hereditary Angioedema (HAE) Families H. Kang1, T. Kim1, H. Park1, S. Oh1, S. Kim1, J. Bahn2, Y. Chang1, Y. Kim1, S. Cho1, K. Min1, Y. Kim1; 1Division of Allergy and Clinical Immunology, Seoul National University Hospital, Seoul, REPUBLIC OF KOREA, 2Division of Pulmonology, Hallym University Hospital, Pyong-Chon, REPUBLIC OF KOREA. Intrinsic Pollen NADPH Oxidases Induce Genes by Activating Innate Immune Responses in Human Bronchial Epithelial Cells R. M. Bloebaum1, I. Boldogh2, L. A. Bruce3, S. Sur1; 1Internal Medicine, UTMB, Galveston, TX, 2Microbiology, UTMB, Galveston, TX, 3Human Biological Chem & Genetics, UTMB, Galveston, TX.

S402 Abstracts

J ALLERGY CLIN IMMUNOL FEBRUARY 2004

2:30 1232 The Effect of Intranasal Steroid Budesonide on Sleep Disturbance and Daytime Somnolence in Patients With Perennial Allergic Rhinitis T. J. Craig, F. Gurevich, C. Glass, W. Wei, E. Lehman; Medicine, Penn State University, Hershey, PA.

Oral Abstract Session 5603 Tuesday, March 23 1:30 PM to 2:45 PM Immunoregulation 1:30 1233 Mucosal ML-1 (IL-17F) Gene Transfer Induces Pulmonary Neutrophil Inflammation N. Oda1, D. M. Essayan2, S. K. Huang1; 1Johns Hopkins Asthma and Allergy Center, Baltimore, MD, 2Food and Drug Administration, Bethesda, MD. 1:45 1234 Disruption of the Stratum Corneum Allows Potent Epicutaneous Immunization With Protein Antigens Resulting in a Dominant Systemic Th2 Response J. Strid1, J. Hourihane2, I. Kimber3, R. Callard1, S. Strobel1; 1Immunobiology, Institute of Child Health, London, UNITED KINGDOM, 2Welcome Trust Clinical Research Facility, Southampton University Hospitals, Southampton, UNITED KINGDOM, 3Syngenta Central Toxicology Laboratory, Macclesfield, UNITED KINGDOM. 2:00 1235 Epicutaneous Antigen Potently Primes for Multiple Systemic Allergic Responses H. Saito1, A. Mishra1, R. T. Strait2, F. D. Finkelman3,4, M. E. Rothenberg1; 1Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Emergency Medicine and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 3Veterans Administration Medical Center, Cincinnati, OH, 4University of Cincinnati, Cincinnati, OH. 2:15 1236 Epicutaneous Exposure to Peanut Prevents Oral Tolerance and Enhances Allergic Sensitisation S. Strobel1, J. Hourihane2, I. Kimber3, R. Callard1, J. Strid1; 1Immunobiology, Institute of Child Health, London, UNITED KINGDOM, 2Welcome Trust Clinical Research Facility, Southampton University Hospitals, Southampton, UNITED KINGDOM, 3Syngenta, Central Toxicology Laboratory, Macclesfield, UNITED KINGDOM. 2:30 1237 Regulatory Signals Mediating Down-Regulation of the Common Beta Chain of the IL-5, IL-3, and GM-CSF Receptors M. Martinez-Moczygemba, J. T. Lei, B. Philip; Medicine/Immunology Allergy & Rheumatology, Baylor College Of Medicine, Houston, TX.

TUESDAY

Oral Abstract Session 5604 Tuesday, March 23 1:30 PM to 2:45 PM New Therapeutics in Skin Disorders 1:30 1238 Immunopharmacological Effects of Topical Tacrolimus in Atopic Dermatitis D. Simon1, E. Vassina2, L. R. Braathen1, H. U. Simon2; 1Dermatology, University of Bern, Bern, SWITZERLAND, 2Pharmacology, University of Bern, Bern, SWITZERLAND.

1:45 1239 The Effect of Elidel 1% Cream on Skin Condition and Sleep Parameters in Children With Mild to Moderate Atopic Dermatitis (AD) H. L. Leo1, B. G. Bender2, S. B. Leung1, Z. V. Tran3, D. Y. M. Leung1; 1Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, CO, 2Division of Pediatric Behavioral Health, National Jewish Medical and Research Center, Denver, CO, 3Division of Psychosocial Medicine, National Jewish Medical and Research Center, Denver, CO. 2:00 1240 Trial of Lexapro (Escitalopram) in Non-Depressed Atopic Dermatitis Adults G. Sharon; Asthma and Allergy Center, Bloomingdale, IL. 2:15 1241 Efficacy and Safety of Efalizumab in Patients With Moderate to Severe Plaque Psoriasis: Pooled Results From Three Phase III Randomized, Placebo-Controlled Trials A. Nayak1, I. Caro2; 1ICSL Clinical Studies, Normal, IL, 2Genentech, Inc., South San Francisco, CA. 2:30 1242 Successful Management of a Case of Diffuse Cutaneous Mastocytosis With Recurrent Anaphylactoid Episodes and Hypertension L. Escribano1, D. García-Belmonte1, A. Hernández-González2, E. Otheo3, R. Núñez-Lopez1, J. L. Vázquez3, S. Quintero4, M. T. Gárate5; 1Mast Cell Unit and K. Frank Austen Laboratory, Hospital Ramón y Cajal, Madrid, SPAIN, 2Hospital Puerta del Mar, Unidad de Cuidados Intensivos, Cádiz, SPAIN, 3Unidad de Cuidados Intensivos, Hospital Ramón y Cajal, Madrid, SPAIN, 4Unidad de Cuidados Intensivos, Hospital Virgen del Mar, Cádiz, SPAIN, 5Servicio de Dermatología, Hospital Ramón y Cajal, Madrid, SPAIN.

Oral Abstract Session 5605 Tuesday, March 23 1:30 PM to 2:45 PM Allergen Structure, Function, and Immune Response 1:30 1243 Structural Basis for Epitopes Sharing Between Group 1 Allergens of Cedar Pollen, Jun a 1 and Cry j 1 T. Midoro-Horiuti1, D. Liu2, M. A. White2, E. W. Czerwinski2, V. Mathura2, C. H. Schein2, W. Braun2, M. Watanabe3, T. Oka4, A. Togawa1, E. G. Brooks1, R. M. Goldblum1; 1Pediatrics, University of Texas Medical Branch, Galveston, TX, 2Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX, 3Tokyo Research Laboratories, Kowa Co. Ltd., Tokyo, JAPAN, 4Oka Pharmacy, Tamano, JAPAN. 1:45 1244 Protease Activity of Der p 1: Cysteine, Serine or Both? N. Sehgal1, S. Ainsworth2, T. Dafforn3, A. Custovic1, A. Woodcock1; 1North West Lung Research Centre, Manchester, UNITED KINGDOM, 2University of Manchester Institute of Science and Technology, Manchester, UNITED KINGDOM, 3University of Manchester, Manchester, UNITED KINGDOM. 2:00 1245 Allergen Immunotherapy Induces Allergen Specific T Cell Tolerance H. Thai-Kemprowski, B. Hunter, V. Plainetr, B. Foster, C. Prussin; Laboratory of Allergic Diseases, National Institutes of Health, Bethesda, MD. 2:15 1246 Mouse Allergen Exposure and Immunologic Responses: IgEMediated Mouse Sensitization, Mouse-Specific IgG and IgG4

Abstracts S403

J ALLERGY CLIN IMMUNOL VOLUME 113, NUMBER 2

2:30 1247 Specific IgG and IgG4 Antibodies to Rat Urinary Allergen in Sensitized and Non-Sensitized Individuals H. Jeal, J. Harris, A. Draper, A. Newman Taylor, M. Jones; Department of Occupational and Environmental Medicine, Imperial College @ NHLI, London, UNITED KINGDOM.

Oral Abstract Session 5606 Tuesday, March 23 1:30 PM to 2:45 PM Food Allergy: Novel Therapies and Management Issues 1:30 1248 A Chinese Herbal Medicine Formula, FAHF-2, Completely Blocks Anaphylaxis in a Murine Model of Peanut Allergy K. D. Srivastava, J. D. Kattan, H. A. Sampson, X. M. Li; Pediatrics, Mt. Sinai School of Medicine, New York, NY. 1:45 1249 Therapeutic Effects of Plasmid Coded Mutated Major Peanut Allergen Arah2 for Peanut Allergy T. F. Zhang, H. A. Sampson, X. M. Li; Mount Sinai School of Medicine, New York, NY. 2:00 1250 The Food Challenge Risk Index: Predicting Positive Open Food Challenges to Milk, Egg and Peanuts in Children S. Kearney1, H. Israel2, K. Ververeli2, S. Kimmel2, B. Silverman1, A. Schneider1; 1Allergy and Immunology, Long Island College Hospital, Brooklyn, NY, 2Lehigh Valley Hospital, Allentown, PA. 2:15 1251 The Distribution of Peanut Allergen in the Environment T. T. Perry1, M. K. Conover-Walker1, M. D. Chapman2, R. A. Wood1; 1Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, 2INDOOR Biotechnologies, Inc., Charlottesville, VA. 2:30 1252 Colic in Breast Fed Infants Is Due to Hypersensitivity to Dietary Proteins Excreted in Breast Milk D. J. Hill1, C. S. Hosking1, N. Roy2, J. B. Carlin3, D. E. M. Francis4, J. Brown1, B. Speirs5; 1Allergy, Royal Children’s Hospital, Parkville, AUSTRALIA, 2Neonatology, Royal Women’s Hospital, Parkville, AUSTRALIA, 3Royal Children’s Hospital, Parkville, AUSTRALIA, 4Murdoch Children’s Research Institute, Parkville, AUSTRALIA, 5Royal Women’s Hospital, Parkville, AUSTRALIA.

Oral Abstract Session 5607 Tuesday, March 23 1:30 PM to 2:45 PM Improving the Cost-Effectiveness of the Care of Asthma 1:30 1253 Reducing Short Acting Beta Agonist Overuse in the Asthma Population C. A. Lamb1, J. Hoban2, L. Glaves3, K. Jahn4, C. Martin5, C. Taci-

nas3, S. Hay3, J. Dotts6, D. Flynn5, M. Kleerup4, J. Williams5, J. McGaw3; 1Kaiser Permanente, Lakewood, CO, 2Kaiser Permanente, Boulder, CO, 3Kaiser Permanente, Denver, CO, 4Kaiser Permanente, Aurora, CO, 5Kaiser Permanente, Westminster, CO, 6Kaiser Permanente, Wheat Ridge, CO. 1:45 1254 Cost of Asthma Rescue and Anti-Allergy Medications Among Asthmatic Children With Prior Anti-Allergy Prescriptions Initiating Asthma Controller Therapy A. Luskin1, D. Bukstein1, V. Sazonov Kocevar2, H. Harris3, D. D. Yin2; 1University of Wisconsin - Madison, Madison, WI, 2Outcomes Research, Merck & Co., Inc., Whitehouse Station, NJ, 3The Institute for Effectiveness Research L.L.C., Bridgewater, NJ. 2:00 1255 Impact of a Comprehensive Asthma Program on Pediatric Inpatient Admissions K. M. Luckett1, S. R. Lemley1, L. C. Roy2, S. L. McDermott3, P. M. Luckett4; 1Asthma Management Program, Children’s Medical Center of Dallas, Dallas, TX, 2Market Research, Children’s Medical Center of Dallas, Dallas, TX, 3Respiratory Department, Children’s Medical Center of Dallas, Dallas, TX, 4Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX. 2:15 1256 Use of a Web-Based Pediatric Asthma Emergency Department Tracking System to Improve Physician Asthma Care and Quality C. M. Walsh-Kelly1, K. J. Kelly2, M. Gorelick1, L. Grabowski2, S. Rogalinski3, P. Christenson3, E. Barthell3; 1Pediatric Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, 2Allergy/Immunology, Medical College of Wisconsin, Milwaukee, WI, 3Infinity Health Care, Mequon, WI. 2:30 1257 Cost-Effectiveness of Physician Peer Leader Education and Practice-Based Redesign in Managed Care: The Pediatric Asthma Care PORT-II Trial S. Sullivan1, T. Lee2,3, D. Blough1, J. Finkelstein4, P. Lozano5,6, T. Inui7, T. Inui7, V. Carey8, E. Wagner5, A. Fuhlbrigge8, K. Weiss2,3; 1Department of Pharmacy, University of Washington, Seattle, WA, 2Midwest Center for Health Services and Policy Research, Hines VA Hospital, Hines, IL, 3Northwestern University Feinberg School of Medicine, Chicago, IL, 4Harvard Medical School and Harvard Pilgrim Healthcare, Boston, MA, 5Center for Healthcare Studies, Group Health Cooperative of Puget Sound, Seattle, WA, 6Department of Pediatrics, University of Washington, Seattle, WA, 7Regenstrief Institute for Healthcare, Indianapolis, IN, 8Harvard Medical School, Boston, MA.

Oral Abstract Session 5608 Tuesday, March 23 1:30 PM to 2:45 PM Molecular Mechanism of Allergy 1:30 1258 The House Dust Mite Protease Allergen Der p 1 Induced IL-8 Production in Human Airway Epithelial Cells Through Activation of ERK1/2 Mitogen-Activated Protein Kinase and AP-1 Signaling Pathways E. Adam1, L. Coulon1, E. Jaumotte1, X. Duhant2, M. D. Hollenberg3, A. Jacquet1; 1Department of Applied Genetics, Institute of Molecular Biology and Medecine, Université Libre de Bruxelles, Gosselies, BELGIUM, 2Department of Immunology, Institute of Interdisciplinary Research, School of Medecine, Université Libre de Bruxelles, Bruxelles, BELGIUM, 3Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Calgary, AB, CANADA.

TUESDAY

E. C. Matsui1, E. J. M. Krop2, G. B. Diette3, R. C. Aalberse4, A. L. Smith5, P. A. Eggleston6; 1Division of Pediatric Allergy and Immunology, Johns Hopkins Univ School Medicine, Baltimore, MD, 2Department of Pulmonology, Academic Medical Center, University of Amsterdam, Amsterdam, NETHERLANDS, 3Division of Pulmonology and Critical Care Medicine, Johns Hopkins Univ School Medicine, Baltimore, MD, 4Department of Allergy, CLB Sanquin Blood Supply Foundation, Amsterdam, NETHERLANDS, 5The Jackson Laboratory, Bar Harbor, ME, 6Division of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD.

S404 Abstracts

1:45 1259 The Variant Arg130Gln of Human IL-13 Has Enhanced Activity in a Mouse Model Compared With the Wild Type IL-13 W. Chen, M. B. Ericksen, G. K. Khurana Hershey; Allergy & Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. 2:00 1260 Unexpected Role for the Extracellular Region of the α Chain in FcεRI Receptor M. Hartman1, S. C. Garman2, D. Lin1, J. P. Kinet1; 1Pathology, Laboratory of Allergy & Immunology, Beth Israel Deaconess Medical Center, Boston, MA, 2Laboratoty of Immunogenetics, National Institute of Allergy and Infectious Diseases National Institutes of Health, Rockville, MD. 2:15 1261 Manchester Asthma and Allergy Study: Polymorphisms in ADAM33 Predict Lung Function at Age 5 Years

J ALLERGY CLIN IMMUNOL FEBRUARY 2004

A. Simpson1, F. Jury2, J. Cakebread3, L. Lowe1, S. Holgate3, A. Woodcock1, W. Ollier2, A. Custovic1, J. Holloway3, S. John2; 1North West Lung Research Centre, Wythenshawe Hospital, Manchester, UNITED KINGDOM, 2Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UNITED KINGDOM, 3Infection, Inflammation and Repair Division, University of Southampton, Southampton, UNITED KINGDOM. 2:30 1262 CRTH2 Polymorphism: Genetic Risk Factor for Near-Fatal Asthma in the Chinese Childhood Population J. L. Huang1, T. Yao1,2, M. L. Kuo3; 1Department of Pediatrics, Chang Gung Children’s Hospital, Taoyuan, TAIWAN REPUBLIC OF CHINA, 2Graduate Institute of Clinical Medical Science, Chang Gung University, Taoyuan, TAIWAN REPUBLIC OF CHINA, 3Department of Microbiology and Immunology, Graduate Institute of Basic Medical Research, Chang Gung University, Taoyuan, TAIWAN REPUBLIC OF CHINA.

TUESDAY