Scientific Abstract Sessions

Scientific Abstract Sessions Poster Session

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Asthma Pathophysiology

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2201 Session Time: Saturday, March 19, 2011 9:45:00 AM - 10:45:00 AM

Delayed Anaphylactic Reactions to Mammalian Meat are not Associated with an Increased Prevalence of Asthma L. A. Kelly, S. L. Pochan, H. R. James, L. J. Workman, P. W. Heymann, S. P. Commins, T. A. E. Platts-Mills; University of Virginia, Charlottesville, VA. Intra-Individual Variation in DNA Methylation of IFNg and IL4 Over Days J. S. Kuriakose, D. Torrone, K. Gauvey-Kern, S. Hsu, M. Niedzwiecki, H. Jiang, F. Perera, R. L. Miller; Columbia University College of Physicians & Surgeons, New York, NY. Exploring The Novel Il-17-producing Cd4+TH2 Memory Cell Subset In Clinically Defined Asthmatic Patients B. Uygungil1, J. A. Bernstein2, Y. Wang1; 1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2University of Cincinnati, Cincinnati, OH. Persistent High FeNO Phenotype in Asthma I. O. Agache, C. Ciobanu; Transylvania University Brasov, Faculty of Medicine, Brasov, ROMANIA. The Effects Of Poly-phenylpropanoid-polysaccharide (PPC) On OVA-sensitized Balb/cJ Mice R. D. Pesek1, D. K. Ledford1, A. Tanaka2, W. G. Bradley2; 1University of South Florida, Tampa, FL, 2Tampa Bay Research Institute, St. Petersburg, FL. Steroid Titration Against Mannitol IN mild to moderate Asthma: the STAMINA community study L. McKinlay1, C. M. Jackson2, P. A. Williamson1, T. C. Fardon1, P. Burns1, K. Clearie1, B. J. Lipworth1; 1UNIVERSITY OF DUNDEE, DUNDEE, UNITED KINGDOM, 2UNIVERSITY OF ST ANDREWS, ST ANDREWS, UNITED KINGDOM. The TCCTG Haplotype (-613C>T, -549T>C, -441C>T, -197T>C and -95G>T) of PTGDR Gene is Associated with Allergic Sensitization I. J. Davila, C. Sanz, M. Isidoro-Garcia, V. Garcia-Solaesa, D. Benito-Pescador, L. Hernandez-Hernandez, E. Moreno, F. J. Muñoz-Bellido, E. Laffond, F. Lorente; Salamanca University Hospital, Salamanca, SPAIN. Impulse Oscillation Technique May Help to Better Discriminate Between Asthmatic Preschool Children and Healthy Controls When Combined with Conventional Spirometry on The Basis of Their Bronchodilator Response Y. H. Shin1, H. M. Jee1, D. W. Jung1, S. H. Choi2, H. Y. Yum3, M. Y. Han1; 1 CHA University College of Medicine, Seoul, KOREA, REPUBLIC OF, 2Kyung Hee University College of Medicine, Seoul, KOREA, REPUBLIC OF, 3Seoul Medical Center, Seoul, KOREA, REPUBLIC OF. Mannitol Challenge Test to Identify Exercise-induced Bronchoconstriction and Refractoriness D. I. SUH, J. K. Lee, Y. Y. Koh;

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Seoul National University Hospital, Seoul, KOREA, REPUBLIC OF. Polymorphisms of the PTGDR and LTC4S Influence Responsiveness to Leukotriene Receptor Antagonists in Korean Children with Asthma H. Kim1, M. Kang2, J. Kwon1, J. Seo1, J. Yu1, B. Kim3, W. Choi2, Y. Shin4, S. Hong1; 1Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, Seoul, KOREA, REPUBLIC OF, 2Asan Institute for Life Sciences, Seoul, KOREA, REPUBLIC OF, 3Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, KOREA, REPUBLIC OF, 4Department of Psychiatry, Severance Hospital, Seoul, KOREA, REPUBLIC OF. Positive Bronchial Challenges To D. Pteronyssinus In Asthmatic Subjects In Absence Of Systemic Atopy P. Campo1, C. Antunez2, C. Rondon1, C. Mayorga2, R. Garcia1, M. Ruiz1, L. Melendez2, J. Rodriguez-Bada2, M. Blanca1; 1Hospital Carlos Haya, Malaga, SPAIN, 2IMABIS Foundation, Malaga, SPAIN.

Asthma Diagnosis

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2202 Session Time: Saturday, March 19, 2011 9:45:00 AM - 10:45:00 AM

The Comparison of Cytokine Levels in Exhaled Breath Condensate between Patients with Allergic Asthma and NonAllergic Asthma and the Correlation With % FEV1 and Asthma Control Test Scores S. Boonpiyathad1, J. Klaewsongkram1, P. Pornsuriyasak2; 1Chulalongkorn University, Bangkok, THAILAND, 2Ramathibodi hospital, Bangkok, THAILAND. The Additional Role of Impairment and Risk in Combination with Lung Function For Assessing Pediatric Asthma Control E. K. Hu, S. Thobani, T. Morphew, P. Huynh, M. Li, L. Scott; LAC+USC Healthcare Network, Los Angeles, CA. Inflammatory Mediators In Exhaled Breath Condensate From Asthmatic Patients Y. Takaku, K. Nakagome, T. Kobayashi, F. Nishihara, T. Soma, K. Hagiwara, M. Kanazawa, M. Nagata; Saitama Medical University, Saitama, JAPAN. Salivary Inflammatory Mediator Profiling and Correlation to Clinical Disease Markers in Pediatric Atopic Asthma F. F. Little1, N. Ryzhenko1, D. M. Delgado1, F. G. Oppenheim2, T. Blicharz3, D. R. Walt3, J. Saams4, E. C. Matsui4; 1Boston University School Medicine, Boston, MA, 2Boston University Goldman School of Dental Medicine, Boston, MA, 3Tufts University, Medford, MA, 4Johns Hopkins University School of Medicine, Baltimore, MD. Usefulness of Measuring Fractional Exhaled Nitric Oxide (FeNO) In Various Respiratory Diseases. H. Nagase, T. Toda, A. Kamiyama, Y. Nakase, N. Sugimoto, H. Yoshihara, M. Kuramochi, H. Tashimo, H. Arai, M. Yamaguchi, N. Suzuki, K. Ohta; Teikyo University, Tokyo, JAPAN. Nitrogen Oxide Metabolites (Nitrite and Nitrate) in Exhaled Breath Condensates (EBC) from Patients with Mild Persistent Asthma, and Effects of Low Dose Combination Therapy Fluticasone Propionate/Salmeterol, 100/50 (FSC 100/50) D. Jourd’heuil, P. J. Feustel, T. Smith, S. Patel, S. Sarathchandra, P. Malone, M. Evans, F. Jourd’heuil, M. Pasha; Albany Medical College, Albany, NY.

SATURDAY

Abstracts  AB271

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB272 Abstracts

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Sputum Hyaluronan as a Biomarker of Airway Remodeling in Severe Asthma A. G. Ayars1, L. C. Altman2, S. Potter-Perigo3, T. N. Wight3, P. Nair4; 1University of Washington, Seattle, WA, 2ASTHMA Inc., Seattle, WA, 3Benaroya Research Institute, Seattle, WA, 4McMaster University, Hamilton, ON, CANADA. Evaluation of Central and Peripheral Airways and Analysis of Airway Inflammation by Impulse Oscillometry in Bronchial Asthma Patients T. Shimoda1, Y. Obase2, M. Imaoka1, R. Kishikawa1, T. Iwanaga1; 1Clinical Research Center, Fukuoka National Hospital, Fukuoka, JAPAN, 2Kawasaki Medical School, Kurashiki, JAPAN. Clinical Characteristics Of Airway Hyperresponsiveness In Allergic Airway Diseases J. Lee, I. Yun, H. Park, J. Cho, T. Oh, J. Park, C. Hong; Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF. Multiple-Flow Analysis Of Exhaled Nitric Oxide In Asthma M. Nagao, H. Tanida, K. Hosoki, T. Fujisawa; Institute for Clinical Research, Mie National Hospital, Tsu, JAPAN. Long-term Patterns of Total Serum IgE in ABPA during Exacerbation and Exacerbation-free Intervals R. Shah, P. A. Greenberger; Northwestern University Feinberg School of Medicine, Chicago, IL. Association between Fractional Exhaled Nitric Oxide and Asthma Control P. Prottasan, K. Maneechotesuwan, P. Vichyanond, O. Jirapongsananuruk, P. Pacharn, N. Visitsunthorn; Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, THAILAND. Treadmill Challenge For Confirmation Of Exercise-induced Bronchoconstriction. C. C. Randolph; Center for Allergy, Asthma & Immunology, Waterbury, CT. The Relationship Between Exhaled Nitric Oxide and Acute Exacerbation of Asthma in Children Y. Rha1, Y. Choi2, S. Choi1; 1Kyunghee University School of Medicine, Seoul, KOREA, REPUBLIC OF, 2Seoul Asan Medical Center, Seoul, KOREA, REPUBLIC OF. Simplified Method for Eucapnic Voluntary Hyperventilation (EVH) Challenge R. R. Rosenthal1, H. Howe2; 1Johns Hopkins School of Medicine, Baltimore, MD, 2self, Vienna, VA. Discovering Laryngomalacia M. S. I. El-Sayed1, M. Farahat1, A. Othman2, A. Ibrahim3; 1Cairo University, Department of Pediatrics, Cairo, EGYPT, 2Sohag University, Department of ENT and Phoniatrics, Sohag, EGYPT, 3Research Fellow at Harvard Medical School, Division of Plastic and Reconstructive Surgery, Boston, MA.

Immunodeficiency and IgG Therapy

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2203 Session Time: Saturday, March 19, 2011 9:45:00 AM - 10:45:00 AM

Elevation of Soluble CD14 levels Supports Chronic Innate Immune Activation in Subjects with CVID, XLA, and SLE Compared to Healthy Subjects D. Nguyen, E. Kellner, S. Hudey, M. Dorsey, P. Sriaroon, J. Sleasman, E. Perez; University of South Florida/All Children’s Hospital, St. Petersburg, FL.

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Pneumococcal Vaccine Responses in Children with Down Syndrome A. Y. Joshi, T. Boyce; Mayo Clinic, Rochester, MN. Impaired Pneumococcal Antibody Titers in Children with Down Syndrome A. Shvarts1, M. Ballow2, K. Senn1, H. Lehman1; 1Women & Children’s Hospital of Buffalo SUNY Buffalo, Buffalo, NY, 2Women & Children’s Hospital of Buffalo, SUNY Buffalo, Buffalo, NY. Low Dose Pneumococcal 23-valent Vaccine is Effective in Children with Poor Responses to 7-valent Conjugated Pneumococcal Vaccine M. P. Vaughn1, A. D. Vaughn1, W. T. Kniker2; 1Alamo Asthma & Allergy Associates, San Antonio, TX, 2Allergy, Asthma, Immunology Associates of S.TX, San Antonio, TX. Characterization of Specific Antibody Deficiency in Adults with Medically Refractory Chronic Rhinosinusitis. T. F. Carr, A. P. Koterba, R. Chandra, L. C. Grammer, D. B. Conley, K. E. Harris, R. Kern, R. P. Schleimer, A. Tripathi-Peters; Northwestern University Feinberg School of Medicine, Chicago, IL. Immunodeficiency in Down Syndrome: Revisiting Recurrent Infections in the Post-Pneumococcal Vaccination Era G. Ram1,2, K. Ostermaier1,2, I. C. Hanson1,2, J. Chinen1,2; 1Baylor College of Medicine, Houston, TX, 2Texas Children’s Hospital, Houston, TX. Immunoglobulin Deficiency in Patients with Diabetes Mellitus N. A. Mazer1, D. Welbourn1, R. K. Bernstein2, A. Rubinstein1; 1Montefiore Medical Center, Bronx, NY, 2Endocrinology Practice, Mamaroneck, NY. Splenomegaly is a Useful Screening Tool for Secondary Complications in Patients With Common Variable Immunodeficiency (CVID) N. M. Chase, D. J. Accetta, M. K. Hintermeyer, J. T. Casper, J. W. Verbsky, J. M. Routes; Medical College of Wisconsin, Milwaukee, WI. Differences in Clinical Outcome in Patients with Common Variable Immunodeficiency Treated with Ig Replacement Therapy: Results from the ESID Database G. Kindle1, K. Warnatz1, O. Paschenko2, D. Kumararatne3, S. S. Kilic4, V. Thon5, T. Witte6, M. Helbert7, T. W. Kuijpers8, A. Exley9, N. Mahlaoui10, G. Notheis11, H. Longhurst12, U. Baumann13, A. Jones 14, N. Kütükcüler15, M. Borte 16, P. Wagström 17, C. Feighery18, A. Szaflarska19, H. Ritterbusch1, S. Reda20, T. Kononova21, Z. Panahloo22, B. Grimbacher23; 1Centre of Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, Freiburg, GERMANY, 2Russian Children’s Clinical Hospital, Moscow, RUSSIAN FEDERATION, 3Cambridge University Hospital NHS Trust (Addenbrooke’s), Cambridge, UNITED KINGDOM, 4Uludag University Medical Faculty, Bursa, TURKEY, 5Masaryk University Medical Faculty, St Anne University Hospital, Brno, CZECH REPUBLIC, 6Department of Clinical Immunology, Hannover Medical School, Hannover, GERMANY, 7 University of Manchester, Manchester, UNITED KINGDOM, 8Emma Children’s Hospital, Academic Medical Center (AMC), Amsterdam, NETHERLANDS, 9Cambridge University Health Partners, Papworth Hospital NHS Foundation Trust, Cambridge, UNITED KINGDOM, 10CEREDIH: The French PID study group, Unité d’Immuno-Hématologie & Rhumatologie pédiatriques, Hôpital Necker-Enfants Malades, Paris, FRANCE, 11Dr v. Haunersches Kinderspital, Ludwig Maximilians University, Munich, GERMANY, 12Barts and the London NHS Trust, London, UNITED KINGDOM, 13 Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, GERMANY,

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of Child Health/Great Ormond Street Hospital, London, UNITED KINGDOM, 15Ege University, Faculty of Medicine, Dept of Pediatric Immunology, Bornova, Izmir, TURKEY, 16Children’s Hospital, Municipal Hospital ‘St Georg’, Academic Teaching Hospital of the University of Leipzig, Leipzig, GERMANY, 17Ryhov County Hospital, Jonkoping, SWEDEN, 18Department of Immunology,Trinity College Dublin & St. James’ Hospital, Dublin, IRELAND, 19 Department of Clinical Immunology, Polish-American Institute of Paediatrics, Medical College, Jagiellonian University, Cracow, POLAND, 20Department of Pediatric Allergy and Immunology, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, EGYPT, 21Research and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow, RUSSIAN FEDERATION, 22Medical Science Department, CSL Behring, Haywards Heath, UNITED KINGDOM, 23Royal Free Hospital & University College London, London, UNITED KINGDOM. Common Variable Immune Deficiency (CVID) and Treatment with Intravenous Immunoglobulin (IVIG) in Pregnancy K. Brinker, H. J. Silk; Atlanta Allergy & Asthma Clinic, Atlanta, GA. Variance in Lymphocyte Subsets of Overweight Patients with Common Variable Immunodeficiency S. Esterow1, L. Katz2, B. Kaplan2; 1Division of Pediatrics, Steven and Alexandra Cohen Children’s Medical Center, North Shore-Long Island Jewish Health System, New Hyde Park, NY, 2Division of Allergy/Immunology, North Shore-Long Island Jewish Health System, Great Neck, NY. A Comparison of Clinical Phenotypes: Selective Immunoglobulin G Deficiency vs. Common Variable Immunodeficiency (CVID) S. A. Taylor-Black, C. Cunningham-Rundles; Mount Sinai School of Medicine, New York, NY. Natural Killer Cell Deficiencies In Children With Herpetic Encephalitis - A Case Series F. Fassio1, M. Giudizi1, R. Biagiotti1, E. Allegro1, E. Maggi1, M. de Martino2, F. Almerigogna1; 1Dept. of Biomedicine, University of Florence, Florence, ITALY, 2Dept. of Pediatrics, University of Florence, Florence, ITALY. The Relationship Between Lymphocyte Numbers and Thymic Function in NICU Admits D. F. McMahon, N. L. Baumann-Blackmore, M. J. Lindstrom, J. M. Kessel, M. W. Baker, C. M. Seroogy; University of Wisconsin, Madison, WI. Stem Cell Transplantation for CD3-delta Deficiency N. Marcus1, H. Takada2, J. Dalal3, J. Regueiro4, W. Friedrich5, C. Roifman1; 1University of Toronto & Affiliated Hospitals, Toronto, ON, CANADA, 2Kyushu University, Fukuoka, JAPAN, 3University of Missouri-Kansas City School of Medicine, Kansas City, MO, 4U n ive r s i d a d Complutense, Madrid, S PA I N , 5Universitätskinderklinik, Ulm, GERMANY. Differences in Ig Replacement Therapy Dosing in Patients with Common Variable Immunodeficiency in Europe: Results from the ESID Database B. Gathmann1, N. Mahlaoui2, K. Warnatz1, T. W. Kuijpers3, S. S. Kilic4, V. Thon5, P. D. Arkwright6, D. Kumararatne7, A. Exley 8, M. Borte 9, A. Jones 10, B. H. Belohradsky 11, U. Baumann12, N. Kütükcüler13, T. Witte14, C. Feighery15, P. Wagström16, H. Longhurst17, R. Linde18, H. Ritterbusch1, E. Farmaki 19 , A. Sediva 20 , E. Papadopoulou-Alataki 21 , Z. Panahloo22, B. Grimbacher23; 1Centre of Chronic Immunodeficiency (CCI), Univ Medical Center Freiburg and Univ of Freiburg, Freiburg, GERMANY, 2CEREDIH: The French PID study group, Unité d’Immuno-Hématologie & Rhumatologie pédiatriques, Hôpital Necker-Enfants Malades,

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Paris, FRANCE, 3 Emma Children’s Hospital, Academic Medical Center (AMC), Amsterdam, NETHERLANDS, 4 Uludag Univ Medical Faculty, Bursa, TURKEY, 5 Masaryk Univ Medical Faculty, St. Anne Univ Hospital, Brno, CZECH REPUBLIC, 6 Univ of Manchester, Manchester, UNITED KINGDOM, 7 Cambridge Univ Hospital NHS Trust (Addenbrooke’s), Cambridge, UNITED KINGDOM, 8 Cambridge Univ Health Partners, Papworth Hospital NHS Foundation Trust, Cambridge, UNITED KINGDOM, 9Children’s Hospital, Municipal Hospital ‘St Georg’, Academic Teaching Hospital of the Univ of Leipzig, Leipzig, GERMANY, 10 Institute of Child Health/Great Ormond Street Hospital, London, UNITED KINGDOM, 11 Dr v. Haunersches Kinderspital, Ludwig Maximilians Univ, Munich, GERMANY, 12 Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, GERMANY, 13Ege Univ , Faculty of Medicine, Dept of Pediatric Immunology, Bornova, Izmir, TURKEY, 14 Department of Clinical Immunology, Hannover Medical School, Hannover, GERMANY, 15 Department of Immunology, Trinity College Dublin & St. James’ Hospital, Dublin, IRELAND, 16Ryhov County Hospital, Jonkoping, SWEDEN, 17Barts and the London NHS Trust, London, UNITED KINGDOM, 18J.W. Goethe Univ Hospital, Immunodeficiency Unit, Department of Pediatrics III, Frankfurt, GERMANY, 19Pediatric Immunology Referral Center, 1st Dept of Pediatrics, Aristotle Univ of Thessaloniki, Thessaloniki, GREECE, 20Department of Immunology, Univ Hospital Motol, Prague, CZECH REPUBLIC, 21Aristotle Univ of Thessaloniki, Medical School, Fourth Department of Pediatrics, Papageorgiou Hospital, Thessaloniki, GREECE, 22 Medical Science Department, CSL Behring, Haywards Heath, UNITED KINGDOM, 23Royal Free Hospital & Univ College London, London, UNITED KINGDOM. Tolerability of Human Immunoglobulin 10% Administered Subcutaneously Following Administration of Recombinant Human Hyaluronidase (rHuPH20) in Primary Immunodeficiency Disease (PIDD) Patients D. Gelmont1, R. L. Wasserman2, I. Melamed3, M. Stein4, A. Rubinstein5, B. McCoy6, W. Engl6, H. Leibl6, R. I. Schiff1, W. J. Grossman1; 1Baxter BioScience, Westlake Village, CA, 2Dallas Allergy Immunology, Dallas, TX, 3Immunoe Health Centers, Centennial,, CO, 4Allergy Associates of the Palm Beaches, North Palm Beach, FL, 5Albert Einstein College of Medicine and Montefiore Hospital, Bronx, NY, 6Baxter BioScience, Vienna, AUSTRIA. Efficacy Analysis of Immune Globulin Subcutaneous (Human), 10% (IGSC) Administered Intravenously or Subcutaneously in Subjects with Primary Immunodeficiency Diseases (PIDD) R. I. Schiff1, R. L. Wasserman2, I. Melamed3, M. Stein4, W. Engl5, H. Leibl5, D. Gelmont1, W. J. Grossman1; 1B a x t e r BioScience, We s t l a k e Vi l l a g e , CA, 2DallasAllergyImmunology, Dallas, TX, 3IMMUNOe, Centennial, CO, 4Allergy Associates of the Palm Beaches, North Palm Beach, FL, 5Baxter BioScience, Vienna, AUSTRIA. The Construction of a Pharmacokinetic Model to Describe Intravenous and Subcutaneous Supplementation of IgG in Patients with Primary Immunodeficiency (PID) M. Bexon1, M. Rojavin2, S. Jolles3, S. Ellis4, J. Sawyer5; 1CSL Behring AG, Berne, SWITZERLAND, 2CSL Behring LLC, King of Prussia, PA, 3Cardiff University School of Medicine, Cardiff, UNITED KINGDOM, 4Keele University, Keele, UNITED KINGDOM, 5Prism Ideas Ltd, Nantwich, UNITED KINGDOM. An Analysis of Safety and Tolerability Data on 10%, 16%, and 20% Formulations of Subcutaneous Immunoglobulin (IGSC) I. Melamed, A. McDonald, A. Neff, A. Beck; ImmunoE International Research Center, Centennial, CO.

SATURDAY

Abstracts  AB273

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB274 Abstracts

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New Immune Globulin Subcutaneous (Human), 10% (IGSC) Product is Well Tolerated in Subjects with Primary Immunodeficiency Diseases (PIDD) W. J. Grossman1, R. L. Wasserman2, I. Melamed3, M. Stein4, W. Engl5, H. Leibl5, R. I. Schiff1, D. Gelmont1; 1B a x t e r BioScience, We s t l a k e Vi l l a g e , CA, 2DallasAllergyImmunology, Dallas, TX, 3IMMUNOe, Centennial, CO, 4Allergy Associates of the Palm Beaches, North Palm Beach, FL, 5Baxter BioScience, Vienna, AUSTRIA. Contribution of Recombinant Human Hyaluronidase (rHuPH20) in Reducing Infusion Pressures During Subcutaneous Delivery of 10% and 20% IgG in Yucatan Micro-Pigs T. Nekoroski; Halozyme Therapeutics, San Diego, CA. Pharmacokinetic Analysis (PK) of Immune Globulin Subcutaneous (Human), 10% (IGSC) Administered Intravenously or Subcutaneously in Subjects with Primary Immunodeficiency Diseases (PIDD) H. Leibl1, R. L. Wasserman2, I. Melamed3, M. Stein4, W. Engl1, R. I. Schiff5, D. Gelmont5, W. J. Grossman5; 1B a x t e r BioScience, Vi e n n a , AU S T R I A , 2DallasAllergyImmunology, Dallas, TX, 3IMMUNOe, Centennial, CO, 4Allergy Associates of the Palm Beaches, North Palm Beach, FL, 5Baxter BioScience, Westlake Village, CA. Improving Subcutaneous Delivery of IgG via Optimizing Delivery Hardware and the Use of Recombinant Human Hyaluronidase (rHuPH20) M. L. Zepeda, G. Y. Fu, J. M. Anderson, M. F. Haller, D. W. Kang; Halozyme Therapeutics, San Diego, CA. U.S. Clinical Experience with Privigen®: A Retrospective Chart Review D. Wong1, R. Hellmers1, D. Wong1, J. S. Baggish2, J. Romano2, A. Koterba3; 1Arizona Allergy Associates, Phoenix, AZ, 2CSL Behring LLC, King of Prussia, PA, 3Arizona Allergy Associates, North Palm Beach, FL. Subcutaneous IgG (SCIG) in the Elderly M. R. Stein1, A. Koterba1, K. Farnan1, D. Eufrasio1, L. Rodden2, M. Berger3; 1Allergy Associates of the Palm Beaches, North Palm Beach, FL, 2CSL Behring, LLC, King of Prussia, PA, 3CSL Behring, LLC, King of Prussia,, PA. Glycine and L-proline Demonstrate Similar IgG Stabilization in Liquid Immunoglobulin Intravenous 10% (IGIV) Formulations A. K. Sun1, Y. Wu2, G. Pot3, E. Vandamme3, W. J. Grossman4, T. Wolfgang5, H. P. Schwarz5; 1Baxter BioScience, Los Angeles, CA, 2Baxter BioScience, Westlake Village, CA, 3Baxter BioScience, Lessines, BELGIUM, 4Baxter BioScience, Deerfield, IL, 5Baxter BioScience, Vienna, AUSTRIA. Compliance with Immunoglobulin Therapy In Patients with Primary Immunodeficiency (PIDD) Treated at Home P. O. Bonnet, A. H. Yoon, Y. Xiong; Baxter Healthcare Corporation, Westlake Village, CA. B-cells and T-cells Cognate Interaction Assay in Common Variable Immunodeficiency N. Rezaei1, J. B. Wing2, A. Aghamohammadi3, A. W. Heath2, R. C. Read2; 1Molecular Immunology Research Center; and Department of Immunology, Tehran University of Medical Sciences, Tehran, IRAN, ISLAMIC REPUBLIC OF, 2Department of Infection and Immunity, School of Medicine and Biomedical Sciences, The University of Sheffield, Sheffield, UNITED KINGDOM, 3Research Center for Immunodeficiencies, Children’s Medical Center, Tehran

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University of Medical Sciences, Tehran, IRAN, ISLAMIC REPUBLIC OF. A young child with Hyper IgE Syndrome (HIES) with a Novel Variant in signal transduction and activator of transcription 3 (STAT3) and Disseminated Histoplasmosis W. Robinson1,2, J. Vickery1,2, C. Michael1,2, S. Arnold1,2, R. Schoumacher1,2, R. Chesney1,2, K. Lakin1,2, J. Ward1,2, E. Pivnick1,2, D. Lew1,2; 1Children’s Foundation Research Center at the Le Bonheur Children’s Hospital, Memphis, TN, 2University of Tennessee Health Science Center, Memphis, TN. Specific Antibody Deficiency In A Patient With Jacobsen Syndrome And Paris-Trousseau Syndrome J. C. Rabbat1,2, J. N. Moy1,2; 1Rush University Medical Center, Chicago, IL, 2Stroger Hospital of Cook County, Chicago, IL.

Modeling Exposure to Understand Disease

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2204 Session Time: Saturday, March 19, 2011 9:45:00 AM - 10:45:00 AM

Use of MODIS Satellite Images and an Atmospheric Dust Transport Model To Evaluate Juniperus Spp. Pollen Phenology and Dispersal to Support Public Health Alerts J. C. Luvall1, W. Sprigg2, E. Levetin3, A. Huete4, S. Nickovic2, G. Pejanovic 2, P. Van de Water 5, O. Myers 6, A. Budge 6, T. Crimmins7, H. Krapfl8, A. Zelicoff9; 1NASA Marshall Space Flight Center, huntsville, AL, 2University of Arizona, Tucson, AZ, 3University of Tulsa, Tulsa, OK, 4University of Arizona, tucson, AZ, 5California State University, Fresno, Fresno, CA, 6University of New Mexico, Albuquerque, NM, 7University of Arizona National Phenology Network, Tucson, AZ, 8New Mexico Department of Health, Albuquerque, NM, 9Ares Corporation, Albuquerque, NM. Associations between Traffic-related Exposures and Incidence of Wheeze among Children Age 5-7 in NYC S. Hsu1, K. H. Jung1, K. Moors1, K. Bernabé1, P. L. Kinney2, S. N. Chillrud3, M. S. Perzanowski2, R. M. Whyatt2, L. A. Hoepner2, S. Wang2, B. Yan3, J. M. Ross3, F. Perera2, R. L. Miller1,2; 1Columbia University Department of Medicine, New York City, NY, 2Columbia University Mailman School of Public Health, Columbia Center for Children’s Environmental Health, New York City, NY, 3Lamont-Dohery Earth Observatory, Palisades, NY. Juniperus asheii (Mountain Cedar) Pollen Utilized As An Antigen In The Biogenics Chamber: Comparison Of Natural And Controlled Exposures D. A. Ramirez, R. L. Jacobs, C. P. Andrews; Biogenics Research Chamber, San Antonio, TX. Diagnosis of Vocal Cord Dysfunction by Irritant Challenges K. A. Pacheco, E. Chenworth, F. B. Blager; National Jewish Health, Denver, CO. Environmental Mouse Allergen Challenge in Urban Adults with Asthma L. K. Chong, E. N. Torjusen, G. B. Diette, P. N. Breysse, S. Biswal, E. C. Matsui; Johns Hopkins University, Baltimore, MD. Repeated Low-dose Aerosolized Dust Mite Allergen Exposure In Asthmatic And Non-asthmatic Dust Mite Allergic Patients In An Environmental Exposure Chamber Induces Specific Asthma Symptoms As Well As Allergic Rhinoconjunctivitis Symptoms. D. Patel, J. S. Lee, D. Wilson, N. Camuso, A. Salapatek; Cetero Research, Mississauga, ON, CANADA.

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Real-Time Particle Counts Provide a Reliable Indication of Airborne Dust Mite Allergen (Der p 1) Concentration and Ensure Controlled and Safe Exposure for Dust Mite Allergic Patients in an Environmental Exposure Chamber (EEC) Model. N. Camuso, D. Wilson, J. S. Lee, A. Salapatek; Cetero Research, Mississauga, ON, CANADA. The Mass of Cat Dander Aerosolized is a Good Predictor of the Real-Time Airborne Fel d 1 Concentration in an Environmental Exposure Chamber (EEC). D. Wilson, N. Camuso, A. Salapatek; Cetero Research, Mississauga, ON, CANADA. Validation Of A Model of Juniperus asheii (Mountain Cedar) Pollen Allergy In The Biogenics Research Chamber R. L. Jacobs, D. A. Ramirez, C. P. Andrews; Biogenics Research Chamber, San Antonio, TX. A Material Prediction Approach for Improving Indoor Air Quality M. L. Spartz, R. S. Fike, A. E. Delia; Prism Analytical Technologies, Inc., Mt. Pleasant, MI. Persistency of Pollens entered Into Homes D. A. Charpin1, M. Calleja2, C. Pichot3; 1Assistance publique- Hôpitaux de Marseille, Marseille, FRANCE, 2Supagro, I.N.R.A., Montpellier, FRANCE, 3I.N.R.A., Avignon, FRANCE.

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Respiratory Syncytial Virus Docking on Lipid Rafts as revealed by Single Virus Tracking H. G. San Juan Vergara1,2, V. P. Sampayo Escobar2, B. Cha1, L. Pacheco Lugo2, N. Reyes Reyes3, S. S. Mohapatra1; 1University of South Florida, Tampa, FL, 2Universidad del Norte, Barranquilla, COLOMBIA, 3Universidad de Cartagena, Cartagena, COLOMBIA. A Novel Fluorescent Labelling Approach to Detect Early Events in RSV-infected Living Cells T. M. Wong1, H. G. San Juan-Vergara1,2, B. Cha1, J. Garay1, M. Teng1, S. S. Mohapatra1,3; 1USF College of Medicine, Tampa, FL, 2Universidad del Norte, Barranquilla, COLOMBIA, 3James A. Haley VA Medical Center, Tampa, FL. Allergic Sensitization Demonstrable Between 3 to 5 Years of Age is Associated with the Development of Viral-induced Illnesses that Increasingly Require more Intensive Corticosteroid Treatment T. E. Pappas1, M. D. Evans2, R. E. Gangnon2, W. M. Lee1, D. J. Jackson1, J. E. Gern1, R. F. Lemanske, Jr.1; 1University of Wisconsin - School of Medicine and Public Health, Madison, WI, 2University of Wisconsin - Population Health Sciences Biostatistics and Medical Informatics, Madison, WI. Higher Rhinovirus-Induced Production of TSLP in Nasal Epithelial Cells from Asthmatic than Healthy Subjects A. Reese, S. Favoreto, J. Quraishi, A. Biyasheva, J. Shen, A. Greiman, P. Avila; Northwestern University, Chicago, IL. Relationship between H1N1 Induced Asthmatic Symptoms and Airway Hyperresponsiveness in Children J. Baek1, Y. Lee1, H. Jee2, K. Kim1, M. Sohn1, K. Kim1; 1 Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF, 2CHA University College of Medicine, Seongnam, KOREA, REPUBLIC OF.

Respiratory Syncytial Virus Nonstructural Protein NS1 Colocalizes with Mitochondrial Antiviral Signaling (MAVS) Protein Following Infection S. Boyapalle; University of South Florida, Tampa, FL. Effect Of Vitamin D And Respiratory Virus Infection In Asthma Preschool Children W. Kim, H. Kim, H. YOON; Inje University, Seoul, KOREA, REPUBLIC OF. H1N1 Influenza in Asthmatic and Allergic Children Hospitalized During the 2009-2010 Pandemic H. Kobayaa, FIT1, B. Asmar2; 1Children’s Hospital of Michigan / DMC/ Wayne State University, Detroit, MI, 2Children’s Hospital of Michigan/ DMC / Wayne State University, Detroit, MI. Increased Surfactant Protein-D In Young Infants With Bronchiolitis H. Chung, J. Shin, M. Ju; School of Medicine, Catholic University of Taegu, Taegu, KOREA, REPUBLIC OF.

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Predictors for Passing Open Food Challenges to Egg and Baked Egg A. L. Economides 1, A. Griswold 2, A. Anagnostopoulos 1, M. Scarupa1, M. White3; 1Institute for Asthma and Allergy, Chevy Chase, MD, 2Boston College, Boston, MA, 3Institute for Asthma and Allergy, Wheaton, MD. Predictors for Passing Open Food Challenges to Milk and Baked Milk A. Griswold1, A. Anagnostopoulos2, M. White3, M. Scarupa2, A. Economides2; 1Boston College, Boston, MA, 2Institute for Asthma and Allergy, Chevy Chase, MD, 3Inst, Wheaton, MD. Early Induction Of Oral Tolerance Protocol (OTI) In Children With Cow’S Milk Allergy. M. Reche1, T. Valbuena1, A. Fiandor2, A. Padial1, A. Cañete1, C. Pascual1; 1Hospital Infanta Sofía, Madrid, SPAIN, 2Hospital Universitario La Paz, Madrid, SPAIN. The Safety of Peanut Oral Immunotherapy in Peanut Allergic Subjects in a Single Center Trial B. Weldon, G. Yu, S. Neale-May, T. Hunter, K. Nadeau; Stanford University, Stanford, CA. Oral Immunotherapy (OIT) of Food Allergy (FA) Successfully Desensitizes Most Patients A. R. Gallucci, R. L. Wasserman, R. W. Sugerman, N. MirekuAkomeah, D. M. Pence, N. A. Long; DallasAllergyImmunology, Dallas, TX. Effect of Peanut Oral Immunotherapy (OIT) on Other Food Allergen-Specific IgE Levels J. A. Bird1, M. Kulis2, N. Kamilaris2, P. Varshney2, L. Pons2, B. Vickery2, A. W. Burks2; 1University of Texas Southwestern Medical Center, Dallas, TX, 2Duke University Medical Center, Durham, NC. Follow-up of the Heated Egg (HE) Diet Trial A. H. Nowak-Wegrzyn, S. A. Leonard, R. Bencharitiwong, S. Noone, H. Lemon-Mule, H. A. Sampson; Mount Sinai School of Medicine, New York, NY.

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Abstracts  AB275

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB276 Abstracts

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Basophil Responses in Children Undergoing Immunotherapy for Milk Allergy P. A. Frischmeyer-Guerrerio, K. Chichester, A. Bieneman, C. Keet, R. A. Wood, J. T. Schroeder; Johns Hopkins University, Baltimore, MD. Early and Persistent Gastrointestinal Side Effects Predict Withdrawal from Peanut Oral Immunotherapy (OIT) B. P. Vickery1, A. M. Scurlock2, P. Steele1, J. Kamilaris1, A. M. Hiegel2, S. K. Carlisle2, T. T. Perry2, S. M. Jones2, A. W. Burks1; 1Duke University, Durham, NC, 2University of Arkansas for Medical Sciences, Little Rock, AR. Treatment Of Severe And Persistent Food Allergy With Omalizumab M. Peña Peloche, M. Hinojosa Macías, B. De La Hoz Caballer, S. Terrados Cepeda, M. Berges Gimeno, B. Huertas Barbudo, E. Álvarez-Cuesta; Allergy Division Ramon y Cajal Hospital, Madrid, SPAIN. Oral Immunotherapy in a Murine Model of Food Allergy Induces Desensitization with High Dose Antigen and Heated or Native Antigen S. A. Leonard, G. Martos, I. Lopez-Exposito, W. Wang, A. NowakWegryzn, C. Berin; Mt Sinai School of Medicine, New York, NY. Milk Oral Immunotherapy (MOI): Interim Results of the First Hundred Patients. Y. Katz, M. Goldberg, M. Levy, M. Stein, A. Elizur, M. Zimmerman, A. Cohen; Assaf-Harofeh Medical Center, Zerifin, ISRAEL. Tolerance To Extensively Heated Milk (HM) In Children With Cow’s Milk Allergy: A Follow Up J. S. Kim, A. Nowak-Wegrzyn, S. R. Noone, R. Bencharitiwong, K. A. Bloom, H. A. Sampson; Mt. Sinai School of Medicine, New York, NY. Baseline Mechanistic Characteristics of Peanut Allergic Children Undergoing Peanut Immunotherapy S. D. Narisety, P. Guerrerio, J. Schroeder, R. Hamilton, R. A. Wood; The Johns Hopkins University School of Medicine, Baltimore, MD. Adverse Reactions During Home Dosing on a Milk Oral Immunotherapy (MOI) Program M. B. Levy, M. R. Goldberg, M. L. Stein, A. Elizur, A. Cohen, M. Zimmerman, Y. Katz; Assaf-Harofeh Medical Center, Zerifin, ISRAEL. Peanut Oral Immunotherapy (OIT) of Food Allergy (FA) Carries a Significant Risk of Eosinophilic Esophagitis (EoE) R. L. Wasserman, R. W. Sugerman, N. Mireku-Akomeah, A. R. Gallucci, D. M. Pence, N. A. Long; DallasAllergyImmunology, Dallas, TX. Omalizumab In Peanut Allergy: Effects On The Basophil, Mast Cell, And Food Challenge Response J. H. Savage, D. MacGlashan, S. S. Saini, R. A. Wood; Johns Hopkins Hospital, Baltimore, MD. Basophil Suppression in Peanut Allergic Patients Undergoing Sublingual Immunotherapy (SLIT) S. J. Chin1, E. H. Kim1, J. A. Bird1, M. D. Kulis1, S. S. Laubach1, L. Pons 1, W. G. Shreffler 2, P. Steele 1, J. S. Kamilaris 1, B. P. Vickery1, A. W. Burks1; 1Duke University Medical Center, Durham, NC, 2Mount Sinai Medical Center, New York, NY. Peanut Oral Immunotherapy (OIT) Induces a Transient Increase in CD4+CD25+FoxP3+ Tregs and a Sustained Decrease of Th2-type Cytokines M. Kulis1, P. Varshney1, A. Scurlock2, B. Vickery1, T. Perry2, S. Jones2, A. W. Burks1;

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University Medical Center, Durham, NC, 2University of Arkansas for Medical Sciences, Little Rock, AR. Basophil Reactivity, IgE and IgG4 Among Subjects with Various Levels of Milk Tolerance L. S. Ford1, K. A. Bloom1, A. H. Nowak-Wegrzyn1, A. Z. Chase1, E. H. Hertzberg1, R. Bencharitiwong1, W. G. Shreffler2, H. A. Sampson1; 1Mount Sinai School of Medicine, New York, NY, 2Massachusetts General Hospital, Boston, MA. Lessons Learnt From The Development Of Tolerance To Cow’s Milk Protein (Cmp): The Importance Of The Oral Food Challenge In Establishing The Diagnosis. N. Rajuan1, M. Goldberg1, M. B. Levy1, M. Leshno2, Y. Katz1; 1Assaf-Harofeh Medical Center, Zerifin, ISRAEL, 2Sackler Faculty of Medicine, Tel Aviv, ISRAEL. Adverse Reactions (AR) during milk Oral Immunotherapy (mOIT) and its Relationship with specific IgE (sIgE) in 105 Milk-allergic Patients. S. Sanchez-Garcia 1, C. Escudero 1, P. Rodriguez del Rio 1, C. Garcia-Fernandez2, C. Ortega-Casanueva1, A. Lopez-Torrijos1, M. D. Ibañez1; 1Hospital Infantil Universitario Niño Jesus, Madrid, SPAIN, 2Hospital Infanta Sofía. Preventive Medicine Department, Madrid, SPAIN. Identification of CCR9+ and CD103+ Dendritic Cells in Tolerance Protocols for Food Allergy M. A. Garcia, G. Yu, A. K. Singh, T. Longbottom, K. C. Nadeau; Stanford University, Stanford, CA. Community Perception and Knowledge of Oral Immunotherapy in Patients With Food Allergies R. S. Traister1, T. D. Green1, L. G. Mitchell2, M. J. Greenhawt3; 1University of Pittsburgh Medical Center, Children’s Hospital of Pittsburgh, Division of Pulmonary and Allergy, Pittsburgh, PA, 2Kids with Food Allergies, Doylestown, PA, 3University of Michigan Health Systems, Division of Allergy and Clinical Immunology, and the University of Michigan Food Allergy Center, Ann Arbor, MI. Non-IgE Mediated Reactions to Milk Oral Immunotherapy (MOI) M. L. Stein, M. R. Goldberg, M. B. Levy, G. Herman, E. Broide, A. Elizur, A. Cohen, M. Zimmerman, Y. Katz; Assaf-Harofeh Medical Center, Zerifin, ISRAEL. Pediatric Liver Transplantation And Food Allergy: Cyclosporine Compared To Tacrolimus Immunosuppression H. Chapdelaine1,2, M. Lebel2, L. Paradis2,1, A. Des Roches2; 1Centre Hospitalier Universitaire de Montréal, Montréal, QC, CANADA, 2CHU Sainte-Justine, Montréal, QC, CANADA. Cloning and High-Level Expression of Recombinant Ara h 6 T. P. Charles1, B. K. Hurlburt1, S. J. Landry2, S. J. Maleki1; 1US Dept. of Agriculture, New Orleans, LA, 2Tulane University Health Sciences Center, New Orleans, LA. High Level Expression of the Acidic and Basic Subunits of Recombinant Ara h 3 C. Garvey, J. B. Nesbit, B. K. Hurlburt, S. J. Maleki; US Dept. of Agriculture, New Orleans, LA. Characterization Of Immune Cytokine Profiles In Food Allergic And Food Sensitized Tolerant 12 Month Old Infants T. D. Dang1, P. V. Licciardi1, P. E. Martin1, J. J. Koplin1, T. Tan1, N. J. Osborne1, M. Tang1,2, K. J. Allen1,2; 1Murdoch Childrens Research Institute, Melbourne, AUSTRALIA, 2Royal Childrens Hospital, Melbourne, AUSTRALIA. Identification of Ara h 2 T-cell Epitopes for Use in a T cellpeptide Vaccine M. Pascal, M. Masilamani, J. Lieberman, H. A. Sampson; Division of Allergy & Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY.

109 A Peanut Allergoid with Increased Safety and Maintained Immunogenicity H. P. M. van der Kleij1, J. Smit2, H. Sleijster-Selis1, R. van den Hout1, L. Gilmartin3, R. Pieters2, E. Kerkvliet1, S. Koppelman1; 1HAL Allergy, Leiden, NETHERLANDS, 2Institute for Risk Assessment Sciences, Immunotoxicology, Utrecht University, Utrecht, NETHERLANDS, 3Charles River Laboratories Preclinical Services, Ballina, IRELAND. 110 Characterization of IgG and IgE Binding to Parvalbumin Derived from Commercially Important Fish Species P. Lee, J. A. Nordlee, S. J. Koppelman, J. L. Baumert, S. L. Taylor; University of Nebraska, Lincoln, NE. 111 Possible Causes Of New Onset Food Allergies In Adult Patients P. Amin, S. Mithani, P. Ponda; North Shore Long Island Jewish Health System, Manhasset, NY. 112 The Role of Breast Milk Immunoglobulins in the Development of Oral Tolerance in a Murine Model of Peanut Allergy K. M. Jarvinen, I. Lopez-Exposito, A. E. Seppo, Y. Song, X. Li; Mount Sinai School of Medicine, New York, NY. 113 Impact of Early Nutrition on Incidence of Allergic Manifestations in the First 3 Years of Life D. M. Scalabrin1, E. E. Birch2,3, J. C. Khoury4, J. Bean4, C. L. Harris1, S. H. Mitmesser1, C. L. Berseth1; 1Mead Johnson Nutrition, Evansville, IN, 2Retina Foundation of the Southwest, Dallas, TX, 3UT Southwestern Medical Center, Dallas, TX, 4Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. 114 Effect of Egg Allergy on Influenza Vaccination S. L. Logsdon, K. F. von Tiehl, A. H. Assa’ad; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. 115 The Prevalence of Childhood Food Allergy in the United States R. S. Gupta1,2, E. E. Springston1,2, M. Warrier3, B. Smith4,5, R. Kumar1,2, X. Wang1, J. Holl2, J. Pongracic1; 1Children’s Memorial Hospital, Chicago, IL, 2Northwestern University, Chicago, IL, 3Allergy, Asthma, and Sinus Care, St. Louis, MO, 4Edward Hines Jr VA Hospital, Hines, IL, 5Loyola University, Maywood, IL. 116 Season of Birth Modifies the Risk of Food Allergy in Infants with Eczema and Food Sensitization in HealthNuts: a Population-based Study P. E. Martin1,2, N. J. Osborne1,2, J. J. Koplin1,2, L. C. Gurrin2, M. Wake1,3, M. L. Tang1,3, M. C. Matheson2, A. J. Lowe1,2, T. Dang1,2, T. Tan1,2, D. Anderson1, M. Sutherland1, L. Thiele1, L. Miles1, A. Ponsonby1, S. C. Dharmage1,2, K. J. Allen1,3; 1Murdoch Childrens Research Institute, Parkville, AUSTRALIA, 2University of Melbourne, Parkville, AUSTRALIA, 3Royal Children’s Hospital, Melbourne, AUSTRALIA. 117 Prevalence of Sensitization to Lipid Transfer Proteins (LTP) and Profilins in a Population of 430 patients in the center of Spain E. GONZALEZ-MANCEBO, D. GONZALEZ-DE-OLANO, M. TRUJILLO, S. SANTOS, M. GANDOLFO-CANO, A. MELENDEZ, R. JUAREZ, P. MORALES, A. CALSO, O. MAZUELA; HOSPITAL DE FUENLABRADA, FUENLABRADA (MADRID), SPAIN. 118 Comparative Study Of Food Allergy In Urban And Rural Schoolchildren : The Europrevall-INCO Survey In China G. W. K. Wong1, J. Li2, Y. Ma3, T. F. Leung1, Y. Z. Chen3, N. S. Zhong2; 1Chinese University of Hong Kong, Hong Kong SAR, CHINA, 2Guangzhou Institute of Respiratory Diseases, Guangzhou, CHINA, 3Capital Institute of Pediatrics, Beijing, CHINA.

Abstracts  AB277

Allergic and Immunologic Skin Diseases 2207 Session Time: Saturday, March 19, 2011 9:45:00 AM - 10:45:00 AM

119 Oral Application Of Bacterial Lysate In Infancy Decreases The Risk Of Infantile Atopic Eczema In A Subgroup Of Children With Paternal Atopy S. G. Lau1, K. Gerhold1, C. Sulser1, S. Rossberg1, I. Witt1, J. Wauer1, J. Beschorner1, R. Bunikowski1, K. Zimmermann2, G. Menke3, U. Wahn1; 1Charité Campus Virchow University Children`s Hospital, Berlin, GERMANY, 2Symbiopharm GmbH, Herborn, GERMANY, 3PAZ GmbH, Frankfort a. M., GERMANY. 120 Evolution of Skin Barrier Function in the First Year of Life R. P. Doyle1, A. D. Irvine2, J. O’B Hourihane1; 1University College Cork, Cork, IRELAND, 2Trinity College Dublin, Ireland, IRELAND. 121 Omalizumab Is Effective On Atopic Dermatitis Patients With Very High Ige Without Neutralizing Serum Ige And Downregulating FceRi On Basophils W. Hung1, J. Chen2, T. Chang2, Y. Chen1,3; 1 Taichung veteran general hospital, Taichung, TAIWAN, 2Genomics Research Center, Academia Sinica, Taipei, TAIWAN, 3School of Medicine, National Yang-Ming University, Taipei, TAIWAN. 122 A Longitudinal Cohort Study of Transepidermal Water Loss in the First Six Months of Life as a Predictor of Atopic Dermatitis. C. McCarthy1, A. Irvine2, D. Murray1, J. O. Hourihane1; 1University College Cork, Cork, IRELAND, 2Trinity College, Dublin, IRELAND. 123 Relationships Between Child, Parent, and Family Factors and Parent Management of Child Atopic Dermatitis A. E. Mitchell1, J. A. Fraser2, J. Ramsbotham1, A. Morawska3, P. Yates1; 1Queensland University of Technology, Brisbane, AUSTRALIA, 2University of Sydney, Sydney, AUSTRALIA, 3University of Queensland, Brisbane, AUSTRALIA. 124 The Epidemiology of Food Sensitization-Associated Eczema in Infancy in HealthNuts, a Population-based Study S. C. Dharmage1,2, P. E. Martin1,2, N. J. Osborne1,2, J. J. Koplin1,2, L. C. Gurrin1, A. Ponsonby2, M. L. Tang2,3, M. C. Matheson1, A. J. Lowe1,2, T. Dang1,2, T. Tan2,1, D. Anderson2, L. Thiele2, M. Sutherland2, L. Miles2, M. Wake2,3, K. J. Allen2,3; 1University of Melbourne, Parkville, AUSTRALIA, 2Murdoch Childrens Research Institute, Parkville, AUSTRALIA, 3Royal Children’s Hospital, Melbourne, AUSTRALIA. 125 Prenatal Probiotic Supplementation is Associated with Reduced sCD14 and Total IgA in Breast Milk I. Ismail1, P. Licciardi1, F. Oppedisano1, S. Donath1, M. Tang1,2; 1Murdoch Childrens Research Institute, Melbourne, AUSTRALIA, 2Royal Children’s Hopsital, Melbourne, AUSTRALIA. 126 Association of Atopic Dermatitis (AD) Severity to Milk and Egg Allergy Outcomes in a Cohort of Atopic, Food-allergic Children (COFAR) A. M. Scurlock1, D. Y. M. Leung2, H. A. Sampson3, R. Lindblad4, A. H. Liu2, R. A. Wood5, S. M. Jones1, M. Plaut6, W. Burks7, D. Stablein4, S. H. Sicherer3; 1UAMS/AR Children’s Hospital, Little Rock, AR, 2National Jewish Health Center, Denver, CO, 3Mt. Sinai School of Medicine, New York, NY, 4EMMES Corporation, Rockville, MD, 5Johns Hopkins University School of Medicine, Baltimore, MD, 6National Institutes of Health/NIAID, Bethesda, MD, 7Duke University Medical Center, Durham, NC.

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J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB278 Abstracts

SATURDAY

127 Long-term Efficacy of Intravenous Immunoglobulin Therapy for Moderate to Severe Atopic Dermatitis in Childhood J. Oh, J. Kim, H. Baik, H. Lee; Hanyang University Guri Hospital, Kyunggi-do, KOREA, REPUBLIC OF. 128 The Efficacy of Wet Wrap Treatment in Children with Atopic Dermatitis T. Song; Ilsan Paik Hospital, Inje University, Goyang, KOREA, DEMOCRATIC PEOPLE’S REPUBLIC OF. 129 Safety of Proactive Topical Corticosteroid Therapy About Adrenal Function and Growth Velocity of Childhood Severe Atopic Dermatitis T. Fukuie1,2, I. Nomura1, M. Futamura1, M. Narita1, Y. Nakagawa2, T. Ohzeki2, K. Matsumoto3, H. Saito3, Y. Ohya1; 1National Center for Child health and Development, Tokyo, JAPAN, 2Hamamatsu University School of Medicine, Shizuoka, JAPAN, 3National Research Institute for Child Health and Development, Tokyo, JAPAN. 130 Fetal Bovine Serum Limits Human Keratinocyte Differentiation and Tight Junction Function T. Yoshida, I. Kuo, A. De Benedetto, M. Behrendt, M. Bolognino, L. A. Beck; University of Rochester Medical Center, Rochester, NY. 131 Allergen-specific TGF-b Producing Regulatory B Cell Responses In Human Cow’s Milk Allergy of Late Eczematous Reactions J. Lee1, H. Park2, G. Noh3, W. Choi4; 1Chungnam National University & Hospital, Taejeon, KOREA, REPUBLIC OF, 2Eulgi University & Hospital, Taejeon, KOREA, REPUBLIC OF, 3Chungnam National University Hospital, Taejeon, KOREA, REPUBLIC OF, 4Konkuk University, TSeoul, KOREA, REPUBLIC OF. 132 Correlates of Severity for Atopic Dermatitis (AD) M. L. DeFelice1,2, E. Yousef1,2, J. Hossain1, S. McGeady1,2; 1Alfred I. duPont Hospital for Children, Wilmington, DE, 2Thomas Jefferson University, Philadelphia, PA. 133 A Differential Effect of 2 Probiotics on Allergic Disease to age 4 years K. Wickens1, P. Black2, T. Stanley1, E. Mitchell3, C. Barthow1, P. Fitzharris4, G. Purdie1, J. Crane1; 1University of Otago, Wellington, NEW ZEALAND, 2Formerly University of Auckland, Auckland, NEW ZEALAND, 3University of Auckland, Auckland, NEW ZEALAND, 4Auckland Hospital, Auckland, NEW ZEALAND. 134 Atopic Dermatitis Associated with Eczema Herpeticum is Associated with Abnormal Expression of Keratin Genes in Skin Biopsies D. N. Grigoryev1, M. D. Howell2, T. N. Watkins1, C. Cheadle1, M. Boguniewicz2, K. C. Barnes1, D. Y. Leung2; 1JHAAC, Baltimore, MD, 2National Jewish Health, Denver, CO. 135 Eczema Action Plans: A Helpful Tool in the Treatment of Pediatric Eczema J. F. Rork1, W. J. Sheehan1,2, J. M. Gaffin1,3, K. G. Timmons1,2, R. Sidbury4, L. C. Schneider1,2, W. Phipatanakul1,2; 1Harvard Medical School, Boston, MA, 2Division of Allergy and Immunology, Children’s Hospital Boston, Boston, MA, 3Division of Respiratory Diseases, Children’s Hospital Boston, Boston, MA, 4Department of Pediatrics, Seattle Children’s Hospital, Seattle, WA. 136 Serum Endotoxin Affects The Severity Of Childhood Atopic Dermatitis J. Kim1, H. Lee1, J. Lee2; 1Uijeongbu St. Mary’s Hosptital, Uijeongbu, KOREA, REPUBLIC OF, 2Seoul St. Mary’s Hosptital, Seoul, KOREA, REPUBLIC OF.

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

137 “The Tolerability And Physiologic Characteristics Wearing A New Acid-coated Textile (ph 5,5-6,5) In Atopic And/or Dry Skin” T. F. M. Jaeger1, M. Rothmaier2, H. Zander3, M. D. Anliker4; 1Department of Dermatology and Allergy Biederstein, Technische Universität München, Munich, GERMANY, 2Empa, Swiss Federal Laboratories for Materials Testing and Research, St. Gallen, SWITZERLAND, 3Weba, Weberei Appenzell AG, Appenzell, SWITZERLAND, 4Dermatology/Allergy, Cantonal Hospital of St. Gallen, St. Gallen, SWITZERLAND. 138 Clinical Relevance of Increased UV-Sensitivity in Patients with Atopic Dermatitis U. Amon, S. Mangalo, A. Roth; PsoriSol Clinic for Dermatology & Allergy, Hersbruck, GERMANY. 139 Obesity in Childhood is Associated With Increased Atopic Dermatitis J. I. Silverberg1,2, E. Kleiman2, H. Lev-Tov2, N. B. Silverberg1, H. G. Durkin2, R. Joks2, T. Smith-Norowitz2; 1Beth Israel Medical and St Lukes-Roosevelt Hospital Centers, New York, NY, 2State University of New York Downstate Medical Center, Brooklyn, NY. 140 Prevalence of Workers’ Compensation and Disability Claims in Patients Undergoing Patch Testing J. A. Tarbox1, M. B. Tarbox2, S. S. Joo1, N. M. Burkemper2; 1Washington University St. Louis, Saint Louis, MO, 2St. Louis University, Saint Louis, MO. 141 Results Of Patch Testing With The Textile Colour And Finish Tray S. M. Herman-Kideckel, D. L. Holness; University of Toronto, Toronto, ON, CANADA. 142 The Incidence of Positive Patch Tests in an Allergy Practice Compared to Published Dermatological Data M. Michelis, H. Morisetty, B. McGoey; Center for Allergy, Asthma & Immune Disorders, P.A, Hackensack, NJ. 143 Distinct Serum Cytokine Profiles Predict Atopic Dermatitis in Children and Adults J. A. Wisniewski, P. W. Wright, J. T. Patrie, P. W. Heymann, J. A. Woodfolk; University of Virginia, Charlottesville, VA. 144 Eythema Multiforme Occurs Following The Clinical Course Of Exanthema Subitum. T. OIshi1, A. Maeda2, T. Sato2, H. Takasugi2, H. HIsakawa2, H. Wakiguchi2; 1Kochi Medical School, Kochi University, Nangoku city Kochi prefecture, JAPAN, 2Kochi university, Nangoku city Kochi prefecture, JAPAN. 145 Hypersensitivity To Nitrile As A Contact Allergen S. Kumar1, J. Moallem2, R. Joks2; 1Virginia Commonwealth University, RICHMOND, VA, 2SUNY Downstate Medical Center, BROOKLYN, NY.

Quality of Life and Other HEDQ Topics 2208 Session Time: Saturday, March 19, 2011 9:45:00 AM - 10:45:00 AM

146 The Clinical Evaluation of Chronic Urticaria Specific Quality of Life Questionnaire (CU-QOL) in Patients with Chronic Urticaria Y. Ye1, Y. Lee2, J. Park3, S. Kim4, J. Choi5, G. Hur6, H. Lee1, E. Lee7, H. Park1; 1 Ajou University School of Medicine, Suwon, KOREA, REPUBLIC OF, 2GF clinic, Seoul, KOREA, REPUBLIC OF,

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3 Yonsei Univesity College of Medicine, Seoul, KOREA, REPUBLIC OF, 4Yonsei University Wonju College of Medicine, Wonju, KOREA, REPUBLIC OF, 5Hallym University School of Medicine, Seoul, KOREA, REPUBLIC OF, 6Korea University College of Medicine, Seoul, KOREA, REPUBLIC OF, 7Graduate School of Public Health, Suwon, KOREA, REPUBLIC OF. Vitamin D Levels in an Outpatient Private Practice Allergy Clinic D. M. Kearney; Center for Allergy, Asthma & Immunology, Waterbury, CT. Quality of Life Differences between Children with and without Atopic Dermatitis L. E. P. Salazar, V. P. Rajamanickam, E. L. Anderson, C. J. Tisler, R. E. Gangnon, D. J. Jackson, J. E. Gern, R. F. Lemanske, Jr.; University of Wisconsin- Madison, Madison, WI. A Randomized Controlled Trial of a Web-Based Educational Intervention for Teaching Allergen Immunotherapy M. A. Rank, G. W. Volcheck, T. Swagger; Mayo Clinic, Rochester, MN. The Association of Quality of Life of Caregivers of Children with Asthma with Asthma Severity and Health Care Utilization M. J. DE VERA, L. M. BRIONES; THE MEDICAL CITY HOSPITAL, PASIG CITY, PHILIPPINES. Association between Anxiety, Depression and Asthma H. Park, M. Kim, K. Lee, K. Kim, D. Jeon, Y. Kim, M. Lee, S. Park; Department of Internal Medicine, Pusan National University School of Medicine, Busan, KOREA, REPUBLIC OF. Knowledge, Compliance, And Quality Of Life(qol) Of Mothers Who Take Care Of Children With Atopic Dermatitis M. Kim1, M. Choi2; 1Childhood Asthma Atopy Center, Asan Medical Center, Seoul, KOREA, REPUBLIC OF, 2Dept. of Nursing, Chung-Ang University, Seoul, KOREA, REPUBLIC OF. The Correlation Between Atopic Dermatitis Disease Severity and Quality of Life is Complex F. C. Lewer1, K. Keat1,2, P. K. Burton1,2, B. S. Frankum1,2, B. Wainstein3,2, C. H. Katelaris1,2; 1University of Western Sydney, Sydney, AUSTRALIA, 2Sydney South West Area Health Service, Sydney, AUSTRALIA, 3Sydney Children’s Hospital, Sydney, AUSTRALIA. Effect of Fluticasone/Salmeterol on Sleep Quality in Patients with COPD E. M. Banta, C. Mende, C. Rhoads, T. J. Craig; Penn State Milton S. Hershey Medical Center, Hershey, PA. A Pediatric Food Allergy Support Group Can Improve Parent and Physician Communication: Results of a Parent Survey A. P. Sharma, T. Prematta, T. Fausnight; Hershey Medical Center-Penn State University, Hershey, PA. Efficacy and Tolerability of Levocetirizine in Improving Symptoms and Health-Related Quality of Life in Patients with Allergic Rhinitis: A Meta-Analysis R. Khianey, M. E. Weinstein; Division of Allergy, Immunology, and Rheumatology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ. Health Related Quality of Life of Asthma and Allergic Rhinitis in Thai School Pupils P. Sritipsukho1, M. Wisai2; 1Department of Pediatrics, Faculty of Medicine, Thammasat University, Prathumthani, THAILAND, 2Payakphumipisai Hospital, Mahasarakham, THAILAND. Analysis of Aeroallergens and Volatile Organic Compounds using air purifiers in relation to inhalant allergy cases at Coulter Animal Hospital N. GHOSH1, Y. Celik1, A. Aranda1, C. Saadeh2;

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1West Texas A & M UNiversity, Canyon, TX, 2Allergy ARTS, Amarillo, TX. Canadian Newspaper Coverage of the A/H1N1 Vaccine Program C. Rachul, N. Ries, T. Caulfield; University of Alberta, Edmonton, AB, CANADA. Effect of Grass Pollen Immunotherapy on Asthma Quality of Life M. I. GARCIMARTIN, R. BARRANCO, M. VAZQUEZ DE LA TORRE GASPAR, F. J. RUANO, N. BLANCA-LOPEZ, E. SEOANE, G. CANTO; HOSPITAL INFANTA LEONOR, MADRID, MADRID, SPAIN. Sleep Archtecture In Hay Fever Paitents In Japan S. CHIBA1,2; 1Stanford University, Palo Alto, CA, 2JIkei University School of Medicine, Tokyo, JAPAN. Media Representations of Allergy and Asthma Issues, Policy and Research: Views from the AllerGen Research Community R. Hyde-Lay, T. Caulfield; Health Law Institute, University of Alberta, Edmonton, AB, CANADA. Atopic Topics: A Report From The Blogosphere G. J. Stadtmauer; Medscape, LLC, New York, NY. A Patient Reported Outcome Diary For Adolescents with Chronic Idiopathic Urticaria: Findings From An Interview Study S. D. Mathias1, M. Matosian1, J. L. Zazzali2; 1Health Outcomes Solutions, Winter Park, FL, 2Genentech, Inc, South San Francisco, CA.

Quality of Care and Adherence 2209 Session Time: Saturday, March 19, 2011 9:45:00 AM - 10:45:00 AM

165 Delivering an Educational Model for Allergic Immunotherapy C. M. Murphy; Veteran’s Administration Boston, West Roxbury, MA. 166 The Right Dose Allergen Immunotherapy Project: Establishing Error Rates and Process Mapping S. Patel, C. L. Oslie, B. Williams, K. Rossow, L. D. Montgomery, J. T. Li, M. A. Rank; Mayo Clinic, Rochester, MN. 167 Availability of Asthma Medicines for Preschool Children in Thailand P. Sangsupawanich, M. Piemwattathaporn, D. Koonrungsrisomboon; Prince of Songkla University, Hatyai, Songkla, THAILAND. 168 Adherence Rates by Nurse Practitioners to the National Asthma Educational Prevention Program (NAEPP) Guidelines M. C. O’Laughlen; University of Virginia, Charlottesville, VA. 169 Physician Knowledge for Pediatric Asthma Management in the Context of Various Asthma Guidelines M. Piemwattathaporn, D. Koonrungsrisomboon, P. Sangsupawanich; Prince of Songkla University, Songkhla, THAILAND. 170 Why Inner City Asthmatic Children Miss Appointments H. Bhatti1,2, E. Secord1, W. Alame1; 1Children’s Hospital of Michigan - Detroit Medical Center, Detroit, MI, 2Case Western Reserve MetroHealth Medical Center, Cleveland, OH. 171 Results of an Annual Survey of Nine Centers from the Jeffrey Modell Network on Patients with Primary Immunodeficiencies F. Modell1, V. Modell1, B. Gee1, P. O. Bonnet2;

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Modell Foundation, New York, NY, 2Baxter Healthcare Corporation, Westlake Village, CA. Can HAE be Identified and Diagnosed Earlier if a Complement 4 Level is Done on All Patients Presenting with Acute Angioedema R. K. Kado, J. Carlson, L. G. Wild; Tulane University, New Orleans, LA.

Immunotherapy in Clinical Practice 2210 Session Time: Saturday, March 19, 2011 9:45:00 AM - 10:45:00 AM

173 Efficacy of Timothy Grass Allergy Immunotherapy Tablet During Peak Grass Pollen Season in North American Children and Adolescents J. Maloney1, D. Skoner2, H. Nolte1, S. Gawchik3, M. Blaiss4; 1Merck Research Laboratories, Kenilworth, NJ, 2Drexel University College of Medicine, Philadelphia, PA, 3Asthma and Allergy Associates, Upland, PA, 4University of Tennessee Health Science Center, Memphis, TN. 174 Lower Respiratory-Related Events in Adults and Children With Allergic Rhinoconjunctivitis Receiving Timothy Grass Allergy Immunotherapy Tablet H. Nolte1, H. S. Nelson2, M. Blaiss3, A. Bufe4, R. Dahl5, S. R. Durham6; 1Merck Research Laboratories, Kenilworth, NJ, 2National Jewish Health, Denver, CO, 3University of Tennessee Health Science Center, Memphis, TN, 4Ruhr University, Bochum, GERMANY, 5 Aarhus University Hospital, Aarhus, DENMARK, 6 Royal Brompton and Harefield Hospitals National Health Service Trust and Imperial College, London, UNITED KINGDOM. 175 Safety of a Short Ragweed Allergy Immunotherapy Tablet in Adults With Ragweed-Induced Allergic Rhinoconjunctivitis and Asthma D. I. Bernstein1, G. J. Atiee2, J. Maloney3, H. Nolte3, A. S. Nayak4; 1University of Cincinnati College of Medicine, Cincinnati, OH, 2ICON Development Solutions, San Antonio, TX, 3Merck Research Laboratories, Kenilworth, NJ, 4Sneeze, Wheeze & Itch Associates, LLC, Normal, IL. 176 Systemic Reactions in a Sample of Multiallergen Cluster Schedule Immunotherapy Patients vs. Conventional Schedule Patients L. J. Stillman; Allergy & Asthma Center, Fort Lauderdale, FL. 177 High Systemic Reaction Rate Using Cluster Build-up Schedule for Aeroallergen Immunotherapy S. S. Laubach, K. McKinney; Walter Reed Army Medical Center, Washington, DC. 178 Venom Iimmunotherapy Given Every 3 or 4 Months is Effective. A Prospective Comparison with the Conventional Regimen L. Simioni1, A. Vianello2, P. Bonadonna2, G. Marcer3, M. Severino4, M. Pagani5, L. Morlin3, M. Crivellaro3, G. Passalacqua6; 1Allergy and Clin Immunology, Int Med Dept, S.Maria del Prato Feltre Hospital, Feltre, ITALY, 2Allergy Unit, Azienda OspedalieraIntegrata, Verona, ITALY, 3Occupational and Environmental Medicine, University of Padua, Padua, ITALY, 4Allergic Clinic, Nuovo Ospedale San Giovanni di Dio, Florence, ITALY, 5Allergy and Oncology Unit, Asola Hospital, Asola, ITALY, 6Allergy and Respiratory Diseases, DIMI, University of Genoa, Genoa, ITALY. 179 Specific Immunotherapy in Treating Atopic Dermatitis: A Systematic Review Using the GRADE System S. Gendelman, D. M. Lang; Cleveland Clinic, Cleveland, OH.

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

180 Consistency Of Clinical Results Throughout Short-term And Long-term Studies With Sublingual 300IR 5-grass Pollen Tablets C. Bachert1, A. Didier2, H. Wahn3, M. Le Gall4, O. De Beaumont4, M. Mélac4, A. Montagut4, H. Malling5; 1Upper Airway Research Laboratory (URL), Department of OtoRhino-Laryngology, Ghent University Hospital, Ghent, BELGIUM, 2Hopital Larrey, Unité allergologie, Toulouse, FRANCE, 3Charity Campus Vrichow Klinikum, Dermatology, Berlin, GERMANY, 4 Stallergenes SA, Antony, FRANCE, 5 National University Hospital, Copenhagen, DENMARK. 181 Safety of RUSH Immunotherapy Using a One-Day Premedication Schedule V. M. Temiño, J. M. Fahrenholz; Vanderbilt Medical Center, Nashville, TN. 182 Prospective Evaluation Of Rate Of Systemic Reactions To Immunotherapy As Part Of A Comprehensive Allergy Practice Quality Improvement Project J. Sheikh; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA. 183 Efficacy Of High-dose Sublingual Immunotherapy In Patients Allergic To Pollen In Real-life Clinical Practice C. Irani, R. Abi Saleh, M. Jammal, F. Haddad; Hotel Dieu De France hospital, Beirut, LEBANON. 184 The Efficacy of Dual Allergen Sublingual Immunotherapy in Subjects with Dermatophagoides farinae and Timothy Grass Allergy as Assessed by the Rhinoconjunctivitis Quality of Life Score C. Santos, N. Reshamwala, S. Vissamsetti, J. Galant, T. Hunter, R. Swami, K. Nadeau; Stanford University - Lucile Packard Children’s Hospital, Palo Alto, CA. 185 Are Primary Care Offices Equipped To Handle Allergy Immunotherapy Related Adverse Events? M. Lunn, L. Leuenberger, R. Houser, F. Tracy; Penn State University Hershey Medical Center, Hershey, PA. 186 Adherence To Sublingual Immunotherapy In Preschool Children G. B. Pajno, D. Vita, G. Crisafulli, L. Caminiti; Istituto Clinica Pediatrica-Policlinico Universitario-MessinaITALY, Messina, ITALY. 187 Subgroup Analyses Of A Large Multinational, Controlled Trial In Allergen Specific Immunotherapy (sit) L. DuBuske; Immunology Research Institute of New England,, Harvard, MA. 188 A 5 Year Prospective Study of Immunotherapy Related Systemic Allergic Reactions J. Melamed, A. Mehra, A. Ahuja Malik, K. Melvin; Allergy & Asthma Specialists, Chelmsford, MA.

Rhinitis Mechanisms 2211 Session Time: Saturday, March 19, 2011 9:45:00 AM - 10:45:00 AM

189 Effect of Azelastine on Substance P Release After Hypertonic Saline Nasal Challenge of Perennial Non Allergic Rhinitis Patients R. Gawlik 1 , B. Rogala 1 , S. Parzynski 1 , B. Jawor 1 , L. M. DuBuske2; 1Silesian University School of Medicine, Katowice, POLAND, 2Immunology Research Institute of New England, Gardner, MA.

190 Local Class Switching In Nasal Mucosa In Non-allergic Rhinitis. J. Kennedy, P. Chen, S. Payne, J. Steinke, L. Borish; University of Virginia, Charlottesville, VA. 191 Nasal Mucosal TRPA1 and TRPV1 Levels in Human Rhinitis L. M. Tourangeau1, S. C. Christiansen1,2, J. Herschbach3, S. M. Brooks4, J. Eddleston1,3, B. Zuraw1,5; 1University of California, San Diego, San Diego, CA, 2Southern California Kaiser Permanente, San Diego, CA, 3Veterans Medical Research Foundation, San Diego, CA, 4University of South Florida, Tampa, FL, 5VA Medical Center, San Diego, CA. 192 Two-photon Excited Fluorescence is Equivalent to Routine Hansel Stain for Identification of Nasal Eosinophils N. Safdarian, Z. Liu, T. D. Wang, E. T. Wang; University of Michigan, Ann Arbor, MI. 193 Development of a Standardized Clinician-Graded Scale for Assessment of Nasal Turbinate Inflammation Induced by Exposure to the Allergen BioCube P. Gomes1, M. B. Abelson1,2, K. Lane1, E. Angjeli1; 1ORA, Andover, MA, 2Schepens Eye Research Institute and Harvard Medical School, Boston, MA. 194 Reference Values And Determinants Of Nasal Nitric Oxide In Healthy Adults S. Kim, T. Kim, H. Kwak, S. Song, J. Sohn, H. Yoon, D. Shin, S. Park, J. Jeong; Hanyang University College of Medicine, Seoul, KOREA, REPUBLIC OF. 195 Nasal and Exhaled Nitric Oxide Monitoring During Specific Inhalation Challenge using a Portable Analyser R. Castano1, D. Miedinger2, J. L. Malo1, M. Desrosiers3; 1Hôpital du Sacré-Coeur de Montréal, Montreal, QC, CANADA, 2University Hospital, Basel, SWITZERLAND, 3CHUM - Hôtel Dieu de Montréal, Montreal, QC, CANADA. 196 Increased IL-5 And IL-13 Cytokine Levels In Ex Vivo Stimulated Whole Blood Cells From Grass Pollen Allergic Donors Correlates With Seasonal Severity Of Pollen Exposure. A. Singh, S. Holvoet, A. Mercenier; Nestle Research Center, Lausanne, SWITZERLAND.

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197 Rhinovirus Infections and Biomarkers of Airway Inflammation Evaluated in Children Treated for Wheezing Exacerbations in Costa Rica J. Posthumus1, M. Soto-Quiros2, L. Avila2, J. Hunt1, H. Carper1, D. Murphy1, H. James1, T. A. E. Platts-Mills1, P. Heymann1; 1University of Virginia Medical Center, Charlottesville, VA, 2Hospital Nacional de Ninos, San Jose, COSTA RICA. 198 Differential Effects of Systemic Corticosteroids on Serum Eosinophil Cationic Protein and Cytokine Profile in Rhinovirusand RS virus-induced Acute Exacerbation of Childhood Asthma M. Kato, Y. Yamada, K. Maruyama, Y. Hayashi; Gunma Children’s Medical Center, Shibukawa, Gunma, JAPAN. 200 Assessments of Airway Inflammation During Experimental Rhinovirus Infections in Allergic Asthmatics A. Stallings, R. Turner, D. Murphy, H. Carper, L. Workman, T. A. E. Platts-Mills, P. Heymann; University of Virginia Medical Center, Charlottesville, VA. 201 Rhinovirus 16 (RV16) Induces Airway Hyperresponsiveness (AHR) and Differential Mediator Release in Human lung slices ex vivo

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C. J. Koziol-White1, P. R. Cooper1, W. Lee2, J. E. Gern2, A. Haczku1, R. A. Panettieri1; 1University of Pennsylvania, Philadelphia, PA, 2University of Wisconsin, Madison, WI. Relationship of Airway Hyperresponsiveness (AHR) and RGS2 Expression in Asthma T. T. Nguyen, Y. Xie, A. I. Berro, Y. Tu, T. B. Casale; Creighton University Medical Center, Omaha, NE. Proof of Concept Study of Serum Vitamin D Levels and Markers of Asthma Severity in Children and Adults D. A. Searing, E. Goleva, A. H. Liu, J. R. Murphy, D. Y. Leung; National Jewish Health, Denver, CO. Relationships Between Folate and Asthma Severity Among Baltimore City Children and Adolescents J. H. Lin1, W. Matsui1, J. N. Saams1, R. D. Peng2, E. C. Matsui1; 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. The Analysis Of The Correlation Between ER22/23EK Polymorphism Of h-GR/NR3C1 Gene And Occurrence Of Severe Bronchial Asthma In Polish Population M. G. Panek1, T. Pietras2, I. Kuprys-Lipinska1, D. Tworek1, K. Oszajca3, R. Wujcik4, P. Górski2, J. Szemraj3, P. Kuna1; 1Department of Internal Diseases, Asthma and Allergy, Medical University of Lodz, Poland; N. Barlicki University Clinical Hospital No. 1 of the Medical University of Lodz, Lodz, POLAND, 2Department of Pneumology and Allergology, Medical University of Lodz, Poland ; N. Barlicki University Clinical Hospital No. 1 of the Medical University of Lodz, Lodz, POLAND, 3Department of Medical Biochemistry, Medical University of Lodz, Lodz, POLAND, 4Faculty of Psychology, Academic School of Social Psychology in Warsaw, Warsaw, POLAND. Absence of the Low Affinity Receptor for Leukotriene B4, BLT2, on NKT Cells Results in Failure to Develop AllergenInduced Airway Hyperresponsiveness and Inflammation Y. Shin1, K. Takeda1, Y. Shiraishi1, Y. Jeong1, Y. Jia1, S. Mathis2, B. Haribabu2, E. W. Gelfand1; 1National Jewish Health, Denver, CO, 2University of Louisville, Louisville, KY. Invariant NKT Cells Are Crucial For The Th2 Biased Adjuvant Activities Of House Dust Extracts A. A. Horner1, G. Wingender2, P. Rogers3, G. Batzer1, M. S. Lee1, D. Bai1, A. Khurana2, M. Kronenberg2; 1UCSD School of Medicine, La Jolla, CA, 2La Jolla Institute for Allergy and Immunology, La Jolla, CA, 3Kyowa Hakko Kirin California Inc, La Jolla, CA. Altered Frequency of Natural Killer T cells Following Allergen or Aspirin Inhalation Challenges in Asthmatics Y. KOH, J. Shim; Chonnam National University Medical School, Gwangju, KOREA, REPUBLIC OF. Peripheral Blood Natural Killer Cells from Asthmatic Subjects Respond Differently to Stimulation with Poly(I:C) and Diesel Exhaust Particles C. V. E. Chehrazi, K. M. Horvath, I. Jaspers; University of North Carolina, Chapel Hill, NC. The Deficiency of PGI2 Signaling Induces STAT6-independent Allergic Airway Inflammation W. Zhou1, D. R. Dowell1, M. M. Huckabee1, D. C. Newcomb1, K. Goleniewska1, G. FitzGerald2, R. S. Peebles Jr.1; 1Vanderbilt University, Nashville, TN, 2University of Pennsylvania, Philadelphia, PA. Differential Expression of MAPK Activators and Phosphatases in Acute, Chronic and Tolerant Asthma R. Alam, N. Goplen, Q. Liang, M. Germinaro, Z. Karim; National Jewish Health, Denver, CO.

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J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB282 Abstracts

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212 Epicutaneous Exposure to Staphylococcal Enterotoxin B Enhances Airway Hyperresponsiveness in a Murine Model of Asthma via an IL-17A Dependent Mechanism J. Yu1,2, M. Oh2, S. Oh2, D. Chen3, Z. Zhu2, T. Zheng2; 1Asan Medical Center, Ulsan University College of Medicine, Seoul, KOREA, REPUBLIC OF, 2The Johns Hopkins Asthma and Allergy Center, Baltimore, MD, 3The University of Texas MD Anderson, Cancer Center, Houston, TX. 213 Enforced Gata3 Expression Increases Susceptibility To Allergic Airway Inflammation In Mice A. KleinJan, M. J. W. De Bruijn, Y. Levani, M. Van Nimwegen, H. C. Hoogsteden, R. W. Hendriks; Erasmus MC, Rotterdam, NETHERLANDS. 214 TLR4 is Essential for Proteinase-Mediated Allergic Lung Disease V. K. Ongeri, S. L. Abramson, D. B. Corry; Baylor College of Medicine, Houston, TX. 215 The Relationship of Fractional Exhaled Nitric Oxide Levels to Allergy and Asthma Biomarkers in Young Adults M. Burnett1, G. Wegienka1, S. Havstad1, D. Ownby2, C. Cole Johnson1, E. Zoratti1; 1Henry Ford Health Systems, Detroit, MI, 2Medical College of Georgia, Augusta, GA. 216 Variable Levels of Cytokines and Chemokines in the Proximal and Distal Asthmatic Airway J. T. Anderson1, M. Zeng1, N. Fineberg1, A. Gaggar1,2, D. D. Chaplin1, M. T. Dransfield1,2, J. S. Deshane1; 1University of Alabama at Birmingham, Birmingham, AL, 2VA Medical Center, Birmingham, AL. 217 Obesity Impairs Monocyte/Macrophage Programming and Efferocytosis in Asthma R. Fernandez-Boyanapalli1, C. Kolakowski1, E. R. Sutherland1,2, D. L. Bratton1,2; 1National Jewish Health, Denver, CO, 2University of Colorado at Denver and Health Science Center, Aurora, CO. 218 An Acute Asthma Attack Induces Tissue Remodeling By Hypersecretion Of Epidermal Growth Factor (egf) And Amphiregulin (areg) In The Airway T. Takamasu1, Y. Enomoto2,3, K. Orihara4, A. Matsuda4, Y. Gon2, H. Saito4, C. Ra2, Y. Okayama2; 1Kanagawa Children’s Medical Center, Yokohama-shi, JAPAN, 2Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Science, Tokyo, JAPAN, 3Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Yokohama, JAPAN, 4Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, JAPAN. 219 PAR-2 Activation by Alternaria alternata Proteases Induces Airway Epithelial Cell Activation and Lung Inflammation M. O. Daines, A. Flynn, C. Sherwood, S. Shultz, J. Hoffman, I. Gruzinova, S. Boitano; University of Arizona, Tucson, AZ. 220 Transcriptional Regulation of Tie2 in Airway Epithelium and it’s Correlation with Severity of Pathophysiological Features in Chronic Asthma T. O. Makinde, G. Ivanov, Z. Shao, D. K. Agrawal; Center for Clinical and Translational Sciences, Creighton University School of Medicine, Omaha, NE. 221 Tranglutaminase 2 Gene Deficiency Results In Decrease Of Airway Resistance And Eosinophilic Inflammation In Murine Asthma Model H. Lee1, E. Shim1, J. Jung1,2, H. Kang1,2, H. Park1,2, S. Kim1,2, S. Cho1,2, S. Chang3, K. Min1,2, Y. Kim4;

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of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, KOREA, REPUBLIC OF, 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, KOREA, REPUBLIC OF, 3Department of Internal Medicine, Sung-Ae General Hospital, Bucheon, KOREA, REPUBLIC OF, 4Eulji Medical Center, Seoul, KOREA, REPUBLIC OF. Airway Cytokine Pattern Predicts Severity of Asthma Symptoms During Colds B. R. Sabin1, A. T. Sabin2, P. McErlean1, T. Ward3, J. Liu3, H. Boushey3, P. Avila1; 1Northwestern University, Chicago, IL, 2Northwestern University, Evanston, IL, 3University of California San Francisco, San Francisco, CA. The Possible Role of Clusterin As a Biomarker Representing Increased Oxidative Stress in Asthma Y. Lee, T. Lee, T. Kim, H. Moon, Y. Cho; Asan Medical Center, Seoul, KOREA, REPUBLIC OF. Munc13-2 And Munc13-4 Double Knock-out Attenuates The Defect Of Airway Mucin Secretion Over 13-2 Null In Murine Airway Metaplasia J. Lee1,2, Z. Azzegagh1, L. Piccotti1, P. Bathina1, M. J. Tuvim1, B. F. Dickey1; 1MD Anderson Cancer Center, Houston, TX, 2Jeju National University, Jeju, KOREA, REPUBLIC OF. Characterization Of Severe Asthma (SA) In Children Of Innercity Of Newark: Altered Responses To Recall Antigens And A Panel Of Agonists Of Toll Like Receptors (TLR). S. Kapoor, L. Geng, A. Feldman, H. Jyonouchi; UMDNJ-New Jersey Medical School, Newark, NJ. Comparison of Allergic Inflammation in the Distal and Proximal Airways G. Rankin1, D. Hall2, S. Wilson1, J. Warner1; 1University of Southampton, Southampton, UNITED KINGDOM, 2GlaxoSmithKline, Stevenage, UNITED KINGDOM. Elevation Of Sputum Plasminogen Activator Inhibitor-1 Levels In The Subjects With Asthma A. Habib1, I. KIM1, S. Lee1, H. Boushey2, T. Ward2, J. Liu2, R. P. Schleimer1, P. Avila1, S. H. Cho1; 1Northwestern, Chicago, IL, 2University of California at San Francisco, San Francisco, CA. Anti-inflammatory And Anti-remodeling Effects Of Tgase 2 Inhibitor On Mouse Ova-specific Allergic Asthma J. Ro1, D. Kim1, G. Hong1, J. Park2, S. Kim3; 1Sungkyunkwan University School of Medicine, Suwon, KOREA, REPUBLIC OF, 2Department of Internal Medicine, Division of Allergy and Immunology, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF, 3Cancer Cell and Molecular Biology Branch, Division of Cancer Biology, Research Institute, National Cancer Center, Goyang, KOREA, REPUBLIC OF. Glutamate Enhances Amphiregulin (AREG) Production from Human Airway Smooth Muscle Cells K. ORIHARA 1, V. Anaparti 1, P. Sharma 1, A. Matsuda 2, K. Matsumoto2, H. Saito2, A. Halayko1, R. Moqbel1; 1University of Manitoba, Winnipeg, MB, CANADA, 2National Research Institute for Child Health & Development, Tokyo, JAPAN. Alveolar Macrophages Mediate Allergic Airway Inflammation In The Obese-asthma Models J. Y. Kim1,2, J. H. Sohn1, J. H. Lee1, C. S. Hong1, J. W. Park1,2; 1Institute of Allergy, Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF, 2Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF.

231 Comparison of Exhaled Nitric Oxide Analysers in Childhood Asthma Y. A. Park1, J. H. Lee1, Y. J. Lee1, T. W. Song2, K. W. Kim1, M. H. Sohn1, K. E. Kim1; 1Department of Pediatrics and Institute of Allergy, Severance Medical Research Institute, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF, 2Department of Pediatrics, Ilsan Paik Hospital, Inje University College of Medicine, Goyang-si, KOREA, REPUBLIC OF. 232 Effects Of Various Respiratory Viruses On Der F-sensitized Asthmatic Mice Y. Chun, J. Yoon, H. Kim, J. Kim, J. Lee; The Catholic University of Korea, Seoul, KOREA, REPUBLIC OF. 233 Serum Levels of Human Chitinase-like Protein YKL-39 was Lower in Childhood Asthma Y. Inoue, N. Shimojo, Y. Suzuki, T. Nakano, Y. Morita, T. Arima, M. Tomiita, Y. Kohno; Graduate School of Medicine, Chiba University, Chiba city, JAPAN. 234 A Specific PAI-1 Inhibitor, PAI-039, Reduced Airway Inflammation And Collagen Deposition In An Ova-challenged Murine Model Of Chronic Asthma S. LEE1, M. Eren2, D. E. Vaughan3, S. H. Cho1; 1 Northwestern University Feinberg School of Medicine, Department of Medicine, Allergy-Immunology Division, Chicago, IL, 2Northwestern University Feinberg School of Medicine, Department of Medicine, Division of Cardiology, Chicago, IL, 3 Northwestern University Feinberg School of Medicine, Department of Medicine, Division of Cardiology, Chicago, IL.

Immune Regulation and Control 2213 Session Time: Saturday, March 19, 2011 9:45:00 AM - 10:45:00 AM

235 Respiratory Viral Infection Leads To Recruitment Of Neutrophils With T Cell Suppressive Functions D. Cheung, A. Rymazewski, S. Ehlenbach, D. Riley, M. H. Grayson; Medical College of Wisconsin, Milwaukee, WI. 236 Dopamine D1-like Receptor Antagonist Attenuates TH17mediated Immune Response and Ovalbumin-antigen Induced Neutrophilic Airway Inflammation K. Nakagome1, H. Okada1, M. Imamura2, K. Kawahata2, T. Inoue1, K. Hashimoto1, F. Nishihara1, H. Harada2, Y. Takaku1, T. Kobayashi1, K. Komiyama1, T. Yamaguchi1, T. Soma1, M. Dohi2, M. Nagata1, S. Matsushita1; 1Saitama Medical University, Saitama, JAPAN, 2Graduate School of Medicine, University of Tokyo, Tokyo, JAPAN. 237 Chlamydophila pneumoniae Infection Induced Antigen Sensitization is Controlled by Regulatory T-cells. T. R. Crother1, N. W. J. Schroder1, A. Slepenkin2, R. Alsabeh1, E. Peterson2, M. Arditi1; 1Cedars-Sinai Medical Center, Los Angeles, CA, 2University of California, Irvine., Irvine, CA. 238 Signaling Mechanism of Tolerance following Repetitive Stimulation with a Single Allergen and its Reversal by Stimulation with Multiple Allergens Z. karim, N. Goplen, M. Gorska, R. Alam; National Jewish Health, Denver, CO. 239 Protective Effect of Thrombomodulin in a Murine Model of Allergen-Induced Asthma T. Takagi1, M. Onishi1, M. Urawa1, M. Naito1, A. Fujiwara1, T. Kobayashi1, H. Kobayashi1, M. Toda1, D. Boveda1, P. Gil-

Abstracts  AB283

Bernabe1, C. N. D’Alessandro-Gabazza1, J. Morser2, O. Taguchi1, E. C. Gabazza1; 1Mie University Graduate School of Medicine, Tsu, Mie, JAPAN, 2Stanford University School of Medicine, Stanford, CA. 240 Glucocorticoid (GC) Modulation of Global miRNA Profile in Human Airway Epithelial Cells C. Stellato1, X. Fang1, K. Abdelmohsen2, M. Gorospe2, F. T. Ishmael3; 1Johns Hopkins University, Baltimore, MD, 2National Institute on Aging, NIH, Baltimore, MD, 3Pennsylvania State University College of Medicine, Hershey, PA. 241 AQX-1125, a Modulator of the SHIP1/PI3K Pathway, Suppresses Chemotaxis and Inflammation J. L. Cross, G. R. Stenton, H. Roberts, L. F. Mackenzie; Aquinox Pharmaceuticals Inc, Richmond, BC, CANADA.

Allied Health Poster Session 2214 Session Time: Saturday, March 19, 2011 9:45:00 AM - 10:45:00 AM

242 Lipid Profile In Patients With Primary Immunodeficiency M. C. Caetano1, R. Silva1,2, C. A. Ferreira1, R. O. S. Sarni1,3, B. T. C. Carvalho1; 1Federal University of Sao Paulo, Sao Paulo, BRAZIL, 2Federal University of Alfenas, Alfenas, BRAZIL, 3Medicine College, Santo André, BRAZIL. 243 Improving Adherence with Initiating New Prescriptions for Inhaled Corticosteroid and EpiPen L. L. Reed; Indiana University, Carmel, IN. 244 Addressing the Need for Improved Patient and Nurse Education on Subcutaneous Immunoglobulin: Enhancing Patient Experiences and Nurse Support N. Bradford1, K. Duff2, L. Mitchell3; 1Children’s Hospital of New Orleans, New Orleans, LA, 2Baxter BioScience, Westlake Village, CA, 3Emory Children’s Center, Fairburn, GA. 245 Comparison of Simple Blood Lancet (Vitrex®) With DuoTip as Skin Prick Test Device among Mite-sensitive Subjects O. BOONYAVIWAT, P. PACHARN, O. PIBOONPOCANUN, N. VISITSUNTHORN, P. VICHYANOND; SIRIRAJ HOSPITAL, MAHIDOL UNIVERSITY, BANGKOK, THAILAND. 246 Survey of Medical Staff Used to Ensure Patients on Supplements are Receiving the Best Health Care M. Emberger; Allergy and Asthma Specialists, P.C., Blue Bell, PA. 247 Safety Of Allergen Immunotherapy On College Campuses D. Mlinarik, C. Radojicic; cleveland clinic, independence, OH. 248 Early Identification of School Children “At-Risk” for Asthma Can Result in Acquisition of Community Based Asthma Care Services C. M. Carcel1, S. Amaro1, M. Morrica2, M. BMarthaler3, M. Grasska1, S. P. Galant1; 1CHOC Children’s Breathmobile, Orange, CA, 2Newport Mesa Unified School Distric, Newport Mesa, CA, 3Newport Mesa Unified School District, Newport Mesa, CA. 249 The Impact of an Evidence-based Continuing Education Course on Participant Self-efficacy and Asthma EducatorCertified (AE-C) Accreditation D. E. Herrick1,2, C. R. Lowe3,2, J. G. Micalizzi1,2, G. S. Kerby1,2; 1 The Children’s Hospital, Aurora, CO, 2 Colorado Asthma Coalition, Denver, CO, 3Kaiser Permanente, Denver, CO.

SATURDAY

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB284 Abstracts

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

SATURDAY

Oral Abstract Session Asthma Therapy

259 Inducible, Antigen Specific IgE-suppression By Gamma-delta T Cells y. huang, M. K. MacLeod, A. S. McKee, M. K. Aydintug, A. David, R. L. O’Brien, W. K. Born; national jewish health, denver, CO.

2601 Session Time: Saturday, March 19, 2011 2:00:00 PM - 3:15:00 PM

Measuring Exposure and Response in Occupational Cohorts

250 ADRB2 (Adrenergic B2 Receptor Agonist Gene) Arg 16 Allele and Effect of LABA Withdrawal in Patients with Moderate to Severe Asthma M. L. Slankard1, S. Canfield1, M. Michelis2, M. Mansukhani1, B. McGoey2, A. Paige1, D. J. Lederer1, E. A. DiMango1; 1Columbia University Medical Center, New York, NY, 2Hackensack University Medical Center, Hackensack, NJ. 251 Response to Albuterol Delivered Through an Anti-Static Valved Holding Chamber During Nocturnal Bronchospasm L. Hendeles, S. Prabhakaran, J. Shuster, S. Chesrown; University of Florida, Gainesville, FL. 252 Inhibitory Effect of Sub-fractions containing mainly flavonoids in KuShen (Radix Sophorae Flavescentis) on Airway Smooth Muscle Contraction B. Liang, T. Slotkin, N. Yang, X. Li; Mount Sinai school of Medicine, New York, NY. 253 IVIg Induces of Foxp3+ Regulatory T-cells in an Antigen Specific Manner in Allergic Airway Disease A. H. Massoud1, K. Shalaby1, D. Chan1, W. M. Mourad2, C. A. Piccirillo1, B. D. Mazer1; 1McGill University, Montreal, QC, CANADA, 2Unversity of Montreal, Montreal, QC, CANADA. 254 Implementation and Impact of a Metered Dose Inhaler Based Asthma Pathway in a Urban University Hospital M. E. Bollinger1, Z. Hasan2, D. Steacy3, K. Rafei1; 1University MD School of Medicine, Baltimore, MD, 2Lake Erie College of Osteopathic Medicine, Erie, PA, 3University of Maryland Medical System, Baltimore, MD.

T Cells 2602 Session Time: Saturday, March 19, 2011 2:00:00 PM - 3:15:00 PM

255 TGF-b, IL-1b, And IL-23 Are Required For IL-13Ra1 Expression On Human Th17 Cells And IL-13 Attenuates IL-17A Production At Restimulation M. M. Huckabee, D. C. Newcomb, M. G. Boswell, K. Goleniewska, S. Reiss, R. S. Peebles, Jr.; Vanderbilt University Medical Center, Nashville, TN. 256 Human IL-27 Suppresses Th2 Cell Differentiation Independent of IFN- and IL-10 S. Wang1, Y. Zhuang2, N. Erekosima2, R. Katial2, R. Alam2, H. Huang1; 1National Jewish Health and University of Colorado Denver, Denver, CO, 2National Jewish Health, Denver, CO. 257 IL-13 Decreases IL-17a Production In Mouse Th17 Cells Through An IL-10 Dependent Mechanism D. C. Newcomb, M. M. Huckabee, M. G. Boswell, K. Goleniewska, S. S. Reiss, R. S. Peebles, Jr.; Vanderbilt Univeristy Medical Center, Nashville, TN. 258 Novel Actions of MEK1 and the Nuclear Co-receptor SMRT in Regulating T cell Function L. Guo, Z. Karim, R. Alam; National Jewish Health, denver, CO.

2603 Session Time: Saturday, March 19, 2011 2:00:00 PM - 3:15:00 PM

260 Performance of FDA-Approved Serologic Testing for Latex Allergy in an At-Risk Population D. J. Accetta1, M. Klancnik1, N. Elms1, M. L. Wang2, R. G. Hoffmann1, V. P. Kurup1, K. J. Kelly1; 1Medical College of Wisconsin, Milwaukee, WI, 2National Institute for Occupational Safety and Health, Morgantown, WV. 261 Cytokine Responses In Trimellitic Anhydride Exposed Factory Workers D. Ghosh, J. A. Bernstein; University of Cincinnati, Cincinnati, OH. 262 Natural Rubber Latex Allergy Among Health Care Workers: Significant Reduction of Sensitization and Clinical Relevant Latex Allergy After Introduction of Powder-free Latex Gloves. N. W. de Jong1, J. A. Patiwael1, H. de Groot2, A. Burdorf1, R. Gerth van Wijk1; 1ErasmusMC, Rotterdam, NETHERLANDS, 2Diaconessenhuis Voorburg, Reinier de Graaf Group, Voorburg, NETHERLANDS. 263 Diagnostic Performance Of A New Mouse Urine Allergen Extract A. E. Norton, K. Smith, K. Buchholz, A. Hoskins, R. Abdolrasulnia, G. A. Plunkett, T. A. Scott, J. Fahrenholz, R. Dworski; Vanderbilt University, Nashville, TN. 264 The Presence of Specific IgG Antibodies to Type II Collagen and Proteoglycans Associated With Specific IgG and IgE to TDI in Firemen with High Exposure Level to Isocyanates in Fire Accidents J. Muino1, M. Romero2, M. Ferrero2, D. Lerda3; 1Universidad Nacional de Córdoba, Cordoba, ARGENTINA, 2LIIDO, Cordoba, ARGENTINA, 3Universidad Católica de Córdoba, Cordoba, ARGENTINA.

Food Allergy 2604 Session Time: Saturday, March 19, 2011 2:00:00 PM - 3:15:00 PM

265 Dipeptidyl Peptidase I as a Serum Marker of Allergic Reactions to Food H. S. Whitworth1, X. Y. Zhou1, L. Lau1, K. Bodey1, M. ErlewynLajeunesse2, F. Millinchamp1, J. Pedersen3, J. S. Lucas1, A. F. Walls1; 1University of Southampton, Southampton, UNITED KINGDOM, 2Southampton University Hospital Trust, Southampton, UNITED KINGDOM, 3Unizyme, Hørsholm, DENMARK. 266 Comparative Safety and Efficacy of Sublingual and Oral Immunotherapy for Milk Allergy C. Keet1, A. Thyagarajan2, S. Boden3, S. Driggers1, R. Hamilton1, A. Burks4, R. Wood1; 1Johns Hopkins School of Medicine, Baltimore, MD, 2Duke University Medical School, Durham, NC, 3Duke University Medical Center, Durham, NC, 4Duke University School of Medicine, Durham, NC.

267 Predictive Value of Peanut Component Specific IgE in a Clinical Population K. Johnson, C. Keet, R. Hamilton, R. Wood; Johns Hopkins School of Medicine, Baltimore, MD. 268 Clinical Factors And Laboratory Correlates Of Milk Allergy Resolution In A Cohort Of Infants With Milk Allergy (CoFAR) R. Wood1, S. Jones2, B. Vickery3, A. Liu4, W. Burks3, D. Fleischer4, D. Stablein5, A. Henning5, L. Mayer6, H. Sampson6, S. Sicherer6; 1Johns Hopkins University, Baltimore, MD, 2University of Arkansas, Little Rock, AR, 3Duke University, Durham, NC, 4National Jewish Health, Denver, CO, 5The Emmes Corporation, Rockville, MD, 6Mount Sinai School of Medicine, New York, NY. 269 Evidence of Desensitization by Sublingual Immunotherapy in Peanut-Allergic Children E. H. Kim1, J. A. Bird1, M. Kulis1, S. S. Laubach1, W. G. Shreffler2, L. Pons1, P. H. Steele1, J. Kamilaris1, B. P. Vickery1, A. W. Burks1; 1Duke University Medical Center, Durham, NC, 2Mount Sinai Medical Center, New York City, NY.

Health Economics and Economic Outcomes 2605 Session Time: Saturday, March 19, 2011 2:00:00 PM - 3:15:00 PM

270 Asthma Related Exacerbation Rates and Costs in Managed Care R. H. Stanford, J. White; GlaxoSmithKline, Research Triangle Park, NC. 271 Impact of Poorly Controlled Asthma on Acute Healthcare Utilization and Costs J. Y. Chen1, J. Zazzali2, H. Tian1; 1IMS Health, Woodland Hills, CA, 2Genentech, South San Francisco, CA. 272 Economic Burden of Asthma in a Commercially Insured Population J. Zazzali1, P. Bajaj2, J. Chen3, H. Tian3; 1Genentech, Inc., South San Francisco, CA, 2University of Washington, Seattle, WA, 3IMS Health, Woodland Hills, CA. 273 Healthcare Utilization and Cost Burden in Patients with Severe Asthma S. P. Nagar, R. H. Stanford, J. White; GlaxoSmithKline, Research Triangle Park, NC. 274 Does Allergen-specific Immunotherapy Provide Cost Benefits for Children and Adults with Allergic Rhinitis? Results from Large-Scale Retrospective Analyses Jointly Funded by AAAAI and ACAAI C. S. Hankin1, L. Cox2, Z. Wang1, A. Bronstone1; 1BioMedEcon, LLC, Moss Beach, CA, 2Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL.

Oral Immunotherapy 2606 Session Time: Saturday, March 19, 2011 2:00:00 PM - 3:15:00 PM

275 Sublingual Immunotherapy: a Randomised Comparison Between Continuous and Seasonal Treatment in Children with Grass Pollen Allergy G. Passalacqua1, G. Pajno2, G. Crisafulli2, L. Caminiti2; 1Allergy and Respiratory Diseases, DIMI, University of Genoa, Genova, ITALY, 2Department of Pediatrics, Allergy Unit, University of Messina, Messina, ITALY.

Abstracts  AB285

276 Effect of Timothy Grass Allergy Immunotherapy Tablet on Allergic Rhinoconjunctivitis Eye Symptoms in North American Adults and Children P. Creticos1, H. Nolte2, D. Skoner3, M. Blaiss4, J. Maloney2, H. S. Nelson5; 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Merck Research Laboratories, Kenilworth, NJ, 3Drexel University College of Medicine, Philadelphia, PA, 4University of Tennessee Health Science Center, Memphis, TN, 5National Jewish Health, Denver, CO. 277 Efficacy of Timothy Grass Allergy Immunotherapy Tablet During Peak Grass Pollen Season in North American Adults H. S. Nelson1, H. Nolte2, P. Creticos3, J. Maloney2, D. I. Bernstein4; 1 National Jewish Health, Denver, CO, 2 Merck Research Laboratories, Kenilworth, NJ, 3Johns Hopkins University School of Medicine, Baltimore, MD, 4University of Cincinnati College of Medicine, Cincinnati, OH. 278 Post-treatment Efficacy Of House Dust Mites (HDM) Sublingual Immunotherapy (SLIT) Tablets In Adult Patients P. Demoly1, M. Worm2, W. Fokkens3, A. Tabar4, H. Nguyen5, O. De Beaumont5, M. Mélac5, A. Montagut5, K. Bergmann2; 1University Hospital of Montpellier, Montpellier, FRANCE, 2Allergy-Centre-Charité, Charité - Universitätsmedizin Berlin, Berlin, GERMANY, 3Department of Otorhinolaryngology, AMC, Amsterdam, NETHERLANDS, 4Department of Allergy, Complejo Hospitalario de Navarra, Pamplona, SPAIN, 5Stallergenes SA, Antony, FRANCE. 279 Efficacy And Safety Of Sublingual 300IR 5-grass Pollen Tablets In Adult Patients With Grass-pollen Rhinoconjunctivitis In United States L. Cox1, T. Casale2, A. Nayak3, D. Bernstein4, S. Mekhaldi5, O. De Beaumont5, M. Mélac5, A. Montagut5, P. Creticos6; 1Stallergenes, Antony, FRANCE, 2Creighton University - Allergy & Asthma, Omaha, NE, 3Sneeze, Wheeze, and Itch Associates, LLC, Normal, IL, 4Bernstein Clinical Research Center, LLC, Cincinnati, OH, 5Stallergenes SA, Antony, FRANCE, 6Johns Hopkins University, Baltimore, MD.

The Role of FceRI in Atopic Disease 2607 Session Time: Saturday, March 19, 2011 2:00:00 PM - 3:15:00 PM

280 Correlation of IgE, Age, and Atopy with FceRI Expression on Peripheral Blood Dendritic Cell Subsets of Children M. Vasudev, T. Dasu, M. H. Grayson; Medical College of Wisconsin, Milwaukee, WI. 281 IgE Cross-linking Alters the Phenotype and Function of Human Monocytes D. M. Pyle, R. S. Gruchalla, J. D. Farrar, M. A. Gill; UT Southwestern Medical Center, Dallas, TX. 282 Cross-linking The High-affinity Receptor For IgE On Murine Lung Conventional Dendritic Cells Induces Ccl2 And Ccl17 Message Expression E. Shakir, D. Riley, M. H. Grayson; Medical College of Wisconsin, Milwaukee, WI. 283 Human Basophils Express the Inhibitory Receptor CD300a (IRp60) V. Sabato1,2, M. Verweij1, C. Bridts1, L. De Clerck1, W. Stevens1, D. Schiavino2, D. Ebo1; 1University of Antwerp, Department of Immunology - Allergology Rheumatology, Wilrijk (Antwerpen), BELGIUM, 2Catholic University, Department of Allergology, Rome, ITALY.

SATURDAY

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB286 Abstracts

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

284 Cross-linking FcRI Alters Interferon Responses to Rhinovirus Infection S. R. Durrani1, D. J. Montville1, V. Rajamanickam1, N. C. Levinsky1, C. J. Tisler1, R. E. Gangnon1, M. A. Gill2, D. J. Jackson1; 1University of Wisconsin School of Medicine and Public Health, Madison, WI, 2University of Texas Southwestern Medical Center at Dallas and Children’s Medical Center, Dallas, TX.

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Allied Health Saturday Oral Abstract Session 2611 Session Time: Saturday, March 19, 2011 2:00:00 PM - 3:15:00 PM

SUNDAY

285 Evaluation of Itching Alleviating Strategies after Skin Testing: Single Blind Placebo-Controlled Randomized Study S. M. Stewart1, E. Yousef1,2, S. Strader1, S. J. McGeady1,2, J. Boscher1, J. Hossain1, A. Haque1,2, D. Schuster1, K. Gorny1; 1Division of Allergy/Immunology, Alfred I. duPont Hospital for Children, Nemours Children’s Clinic, Wilmington, DE, 2Thomas Jefferson University, Philadelphia, PA. 286 Do Peanut Oral Food Challenges Produce More Stress? Selfreported Anxiety Measurement Of Food Allergic Children And Their Parents Prior To Oral Food Challenges M. Paterakis1, K. Mudd1, T. Holbrook1, G. Page2, D. Gross2, R. Wood1; 1Johns Hopkins University, Baltimore, MD, 2Johns Hopkins University School of Nursing, Baltimore, MD. 287 Patch Testing in the Allergist’s Office: A Retrospective Review of Five Year’s Experience S. H. Axelrod, M. Camacho-Halili, F. Khan, S. Leon, M. Aquino, M. Davis-Lorton, L. Fonacier; Winthrop University Hospital, Mineola, NY. 288 High Level of SABA and OCS Use in Young Children with Poorly Controlled Asthma Prescribed Inhaled Fluticasone C. Vibbert 1 , A. Butz 2 , M. Donithan 3 , M. Tsoukleris 4 , M. Bollinger1; 1University of Maryland School of Medicine, Baltimore, MD, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Johns Hopkins University School of Public Health, Baltimore, MD, 4University of Maryland School of Pharmacy, Baltimore, MD. 289 Nasal Challenge to Indoor Particulate Matter (PM) Does Not Lead to Local or Systemic Eosinophilia M. C. Ong1, P. N. Breysse2, G. B. Diette1, B. M. Thomas1, P. J. Lenehan1, J. Curtin-Brosnan1, E. C. Matsui1; 1Johns Hopkins University, Baltimore, MD, 2Johns Hopkins School of Public Health, Baltimore, MD. ModeratorKari L. Rossow, PA-C

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Asthma Epidemiology I 3201 Session Time: Sunday, March 20, 2011 9:45:00 AM - 10:45:00 AM

290 Impact of Exercise-Related Respiratory Symptoms on School Activities in Children With Asthma: Results from the EIB Landmark Survey N. Ostrom1, N. Eid2, T. Craig3, G. Colice4, M. Hayden5, J. Parsons6, S. Stoloff7; 1Allergy & Asthma Medical Group and Research Center, San Diego, CA, 2University of Louisville School of Medicine, Louisville, KY, 3Pennsylvania State University, Hershey, PA, 4Washington Hospital Center, Silver Spring, MD, 5University of Virginia, Charlottesville, VA, 6Ohio State University Asthma

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Center, Columbus, OH, 7University of Nevada School of Medicine, Reno, NV. Comparing Asthma in America (AIA) and Asthma Insight and Management (AIM) Surveys - Did Asthma Burden and Management Improve in the United States Between 1998 and 2009? R. A. Nathan1, S. W. Stoloff2, M. Blaiss3, E. O. Meltzer4, D. E. Doherty5, K. R. Murphy6; 1Asthma and Allergy Associates, P.C. and Research Center, Colorado Springs, CO, 2University of Nevada School of Medicine, Reno, NV, 3University of Tennessee Health Science Center, Memphis, TN, 4Allergy and Asthma Medical Group and Research Center, San Diego, CA, 5Division of Pulmonary, Critical Care, and Sleep Medicine-University of Kentucky, Lexington, KY, 6Boys Town National Research Hospital, Boys Town, NE. Physician-Reported Asthma Control and Management From the Asthma Insight and Management (AIM) Survey S. Stoloff1, R. A. Nathan2, M. Blaiss3, E. O. Meltzer4, D. E. Doherty5, K. R. Murphy6; 1University of Nevada School of Medicine, Reno, NV, 2Asthma and Allergy Associates, P.C. and Research Center, Colorado Springs, CO, 3University of Tennessee Health Science Center, Memphis, TN, 4Allergy and Asthma Medical Group and Research Center, San Diego, CA, 5Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky, Lexington, KY, 6Boys Town National Research Hospital, Boys Town, NE. Asthma And Proinflammatory Conditions: A Population-based Retrospective Matched Cohort Study H. Yun1,2, E. Knoebel1, Y. Fenta1, S. E. Gabriel3, C. Leibson4, E. V. Loftus, Jr.3, V. Roger3, B. Yawn5, B. Li4, Y. Juhn1; 1Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, 2Department of Medicine, Harbor Hospital, Baltimore, MD, 3Department of Internal Medicine, Mayo Clinic, Rochester, MN, 4Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 5Department of Research, Olmsted Medical Center, Rochester, MN. The Overall Burden Experienced by Asthma Patients Interviewed in the Asthma Insight and Management (AIM) Survey E. O. Meltzer1, D. E. Doherty2, R. A. Nathan3, K. R. Murphy4, S. W. Stoloff5, M. Blaiss6; 1Allergy and Asthma Medical Group and Research Center, San Diego, CA, 2Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky, Lexington, KY, 3Asthma and Allergy Associates, P.C. and Research Center, Colorado Springs, CO, 4Boys Town National Research Hospital, Boys Town, NE, 5University of Nevada School of Medicine, Reno, NV, 6University of Tennessee Health Science Center, Memphis, TN. A Population-Based Study on the Association between Birth Weight and Risk of Asthma: A Propensity Score Approach H. Yang1,2, R. Qin1, S. Katusic1, Y. J. Juhn1; 1Mayo clinic, Rochester, MN, 2Soonchunhyang University Hospital, Seoul, KOREA, REPUBLIC OF. Relationship Between Childhood BMI And Asthma In Young Adults In A Birth Cohort. M. Porter1, S. Havstad1, G. Wegienka1, D. Ownby2, C. Cole Johnson1, C. Nageotte1, E. Zoratti1; 1Henry Ford Hospital, Detroit, MI, 2Medical College of Georgia, Augusta, GA. The Influence of Cesarean section on the Incidence of Childhood Asthma: A Propensity Score Approach B. Kim1,2, R. Qin3, S. Katusic3, Y. J. Juhn1; 1Department of Pediatric and Adolescent Medicine Mayo Clinic, Rochester, MN, 2Department of Pediatrics, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung-Si,

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KOREA, REPUBLIC OF, 3Department of Health Sciences Research Mayo Clinic, Rochester, MN. Patient and Physician Differences in Understanding Asthma Symptom Deterioration Terminology From the Asthma Insight and Management (AIM) Survey D. E. Doherty1, E. O. Meltzer2, S. W. Stoloff3, K. R. Murphy4, R. A. Nathan5, M. Blaiss6; 1Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky, Lexington, KY, 2Allergy and Asthma Medical Group and Research Center, San Diego, CA, 3University of Nevada School of Medicine, Reno, NV, 4Boys Town National Research Hospital, Boys Town, NE, 5Asthma and Allergy Associates, P.C. and Research Center, Colorado Springs, CO, 6University of Tennessee Health Science Center, Memphis, TN. Association of Obesity with Asthma in Japanese Preschool Children Y. Adachi1, T. Itazawa1, Y. S. Adachi1, Y. Ito1, Y. Okabe1, K. Yoshida2, Y. Ohya2, H. Odajima3, A. Akasawa4, T. Miyawaki1; 1Department of Pediatrics, University of Toyama, Toyama, JAPAN, 2National Center for Child Health and Development, Tokyo, JAPAN, 3Fukuoka National Hospital, Fukuoka, JAPAN, 4Tokyo Metropolitan Children’s Medical Center, Tokyo, JAPAN. Risk of Asthma in Former Late Preterm Infants: A Propensity Score Approach G. A. Matthews, R. Qin, S. K. Katusic, Y. J. Juhn; Mayo Clinic, Rochester, MN. Assessing the Impact of Asthma and Exercise-Induced Bronchospasm/Exercise-Induced Asthma in the General Population: Results from the EIB Landmark Survey S. Stoloff1, G. Colice2, M. Hayden3, T. Craig4, N. Ostrom5, N. Eid6, J. Parsons7; 1University of Nevada School of Medicine, Reno, NV, 2Washington Hospital Center, Silver Spring, MD, 3University of Virginia, Charlottesville, VA, 4Pennsylvania State University, Hershey, PA, 5Allergy & Asthma Medical Group and Research Center, San Diego, CA, 6University of Louisville School of Medicine, Louisville, KY, 7Ohio State University Asthma Center, Columbus, OH. Pollen Counts Predict Rates Of Emergency Department Visits For Asthma And Other Respiratory Related Illnesses. A. Mehra1, P. Lall2, P. Hemmers3, Y. Adjepong4; 1Mehraji LLC, New York, NY, 2Bridgeport Hospital (Yale New Haven), Bridgeport, CT, 3Allergy Associates of Fairfield County, Allergy Center of Connecticut, Bridgeport, CT, 4Yale University School of Medicine, Bridgeport, CT. Epidemiological Characteristics in Japanese asthmatic adolescents M. Furukawa 1, K. Yoshida2, T. Itazawa3, Y. Murakami4, Y. Adachi3, H. Odajima5, A. Akasawa1; 1Tokyo Metropolitan Children’s Medical Center, TOKYO, JAPAN, 2National Center for Child Health and Development, TOKYO, JAPAN, 3University of Toyama, TOYAMA, JAPAN, 4Fukuoka National Hospital, FUKUOKA, JAPAN, 5Fukuoka National Hospital, FUKUOKA, JAPAN. Relationship Between “Morning Dipping” in Peak Expiratory Flow (PEF) or Peak Expiratory Flow Variability (PEFV) and Study Withdrawals: Post Hoc Analysis of a Randomized 12-Week Study in Patients with Moderate to Severe Asthma J. G. Zangrilli, U. J. Martin; AstraZeneca LP, Wilmington, DE. Association of Body Composition with Asthma Control in Preschool Children T. Itazawa1, Y. Adachi1, Y. S. Adachi1, Y. Ito1, Y. Okabe1, K. Yoshida2, Y. Ohya2, H. Odajima3, A. Akasawa4, T. Miyawaki1; 1Department of Pediatrics, University of Toyama, Toyama, JAPAN, 2National Center for Child Health and Development, Tokyo,

Abstracts  AB287

JAPAN, 3Fukuoka National Hospital, Fukuoka, JAPAN, 4Tokyo Metropolitan Children’s Medical Center, Tokyo, JAPAN. 306 Prevalence of Recurrent Wheezing in Infancy: Time Trends in the EISL Phase III H. J. Chong Neto, N. A. Rosário, F. C. Silva, L. F. M. Bojarski, E. A. Grasselli, C. S. Rosário, B. A. Rosário, F. H. Chong; Federal University of Parana, Curitiba, BRAZIL. 307 Sensitive and Specific Universal RT-qPCR Profiling of miRNAs J. Wang, K. Li, R. F. Lockey, S. Mohapatra, S. S. Mohapatra; University of South Florida, Tampa, FL.

Asthma Treatment I 3202 Session Time: Sunday, March 20, 2011 9:45:00 AM - 10:45:00 AM

308 TPI ASM8 Decreases Inflammatory Markers and Improves Airway Responsiveness in Asthmatics R. Pageau1, G. Gauvreau2, R. Seguin1, D. Carballo1, H. D’Anjou1, H. Campbell2, R. Watson3, M. Parry-Billings1, K. Killian2, P. Renzi4; 1Pharmaxis, Montreal, QC, CANADA, 2McMaster University, Hamilton, ON, CANADA, 3McMaster University, Hamilton, ON, CANADA, 4University of Montreal, Montreal, QC, CANADA. 309 Comparison of Ipratropium Bromide and Albuterol Sulfate Chlorofluorocarbon Metered-Dose Inhaler and Albuterol Hydrofluoroalkane Metered-Dose Inhaler in a Crossover Trial in Patients with Moderate-to-Severe Asthma E. R. Bleecker1, W. W. Busse2, J. F. Donohue3, S. Garfinkel4, T. Lystig4, R. C. Manuel4, R. Schlenker-Herceg4, R. A. Wise5; 1Wake Forest University Center of Genomics and Personalized Medicine, Winston-Salem, NC, 2University of Wisconsin, Madison, WI, 3University of North Carolina, Chapel Hill, NC, 4Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, 5Johns Hopkins University School of Medicine, Baltimore, MD. 310 Do Long-Acting Beta-Agonists Increase the Risk of Fatal or Near-Fatal Asthma in Children? A Case-Control Study T. S. Jacobs1, B. L. Jones2, A. J. MacGinnitie1; 1Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 2University of Pittsburgh School of Medicine, Division of General Internal Medicine, Pittsburgh, PA. 311 Evaluation Of The Bronchodilator Response Phenotype (BDR ≥ 10%) As A Risk Factor For Difficult To Control Asthma S. P. Galant1, T. L. Morphew2, O. Guijon1, K. Hioe1, O. Liao1; 1Children’s Hospital of Orange County, Orange, CA, 2Asthma and Allergy Foundation of America, Los Angeles, CA. 312 The Pathobiologic Effect of Montelukast and Inhaled Budesonide on Exercise-induced Bronchoconstriction in Children H. Baek; Hanyang University Hospital, Seoul, KOREA, REPUBLIC OF. 313 Efficacy of Reslizumab in Patients with Poorly Controlled Eosinophilic Asthma: Subgroup Analysis of Patients with Nasal Polyps S. Mathur1, M. Castro2, F. Hargreave3, F. Xie4, H. J. Wilkins4, T. Henkel4, P. Nair3; 1University of Wisconsin, Madison, WI, 2Washington University School of Medicine, St. Louis, MO, 3McMaster University, Hamilton, ON, CANADA, 4Cephalon, Inc., Frazer, PA. 314 A 26-Week, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Effect of Omalizumab on Markers of Asthma Impairment in Patients With Persistent Allergic Asthma M. Figliomeni, F. Kianifard, X. Meng; Novartis Pharmaceuticals Corporation, East Hanover, NJ.

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J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB288 Abstracts

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315 Randomized Placebo Controlled Study of Ciclesonide in Preschool Children with Recurrent Wheeze and a Positive Asthma Predictive Index or Atopy P. L. P. Brand1, K. Jagannath2, M. L. Garcia-Garcia3, A. Morison4, J. H. Vermeulen5, H. C. Weber6; 1Isala klinieken, Zwolle, NETHERLANDS, 2Thoracic Research Institute, Chennai, INDIA, 3Hospital Universitario Severo Ochoa, Leganés, Madrid, SPAIN, 4Victoria Hospital, Cape Town, SOUTH AFRICA, 5Panorama Medi-Clinic, Cape Town, SOUTH AFRICA, 6Jan S Marais Hospital, Cape Town, SOUTH AFRICA. 316 Isotonic Saline Subjected to Taylor-Couette-Poiseuille Flow Demonstrates Anti-Inflammatory Activity in a Rat Model of Allergic Asthma S. Ghosh, T. L. Mega, S. German, L. M. Burke, M. L. Diegel, A. B. Wood, R. L. Watson; Revalesio Corporation, Tacoma, WA. 317 Ineffectiveness of High-dose Inhaled Corticosteroids for control of Pre-exacerbation Asthma Symptoms; A Randomized Controlled Trial E. Yousef1, J. Hossain2, S. Mannnan3; 1King Faisal Specialist Hospital & Research Centre, Jeddah, SAUDI ARABIA, 2DuPont Hospital for Children, Wilmington, DE, 3Adult and Pediatric Allergy Center of North Virginia, Herndon, VA. 318 Protection against Exercise-Induced Bronchoconstriction Two Hours after a Single Dose of Montelukast in Children Y. Wasfi1, J. P. Kemp2, C. Villarán3, R. Massaad1, W. Xin1, S. S. Smugar1, B. A. Knorr1, G. Philip1; 1Merck & Co., Inc., Whitehouse Station, NJ, 2University of California School of Medicine, San Diego, CA, 3Clínica Ricardo Palma, Lima, PERU. 319 A Post-Hoc Analysis Of Asthma Control And Lung Function Following Treatment With Ciclesonide 80 µg HFA-MDI Twice Daily In Subjects With Mild-to-Moderate Persistent Asthma Previously Receiving Low Dose Fluticasone Propionate/ Salmeterol B. Prenner1, E. O. Meltzer2, S. Y. Desai3, J. Karafilidis3, J. Walsh3; 1Allergy Associates Medical Group Inc, San Diego, CA, 2Allergy and Asthma Medical Group & Research Ctr, San Diego, CA, 3Sepracor Inc, Marlborough, MA. 320 Thiazolidinediones Improve Asthma Control In Diabetic Asthmatics S. C. Christiansen1,2, M. Schatz1, J. Eddleston3, A. WagelieSteffen2, S. Yang1, W. Chen1, B. Zuraw2; 1Southern California Kaiser Permanente Medical Grp, San Diego, CA, 2University of California San Diego, La Jolla, CA, 3Veterans Medical Research Foundation, San Diego, CA. 321 Mometasone Furoate/Formoterol Combination Therapy Increases Frequency of Days/Nights Free of Short-Acting b2Agonist Use A. S. Nayak1, R. A. Nathan2, E. O. Meltzer3, S. F. Weinstein4, H. Nolte5; 1Sneeze, Wheeze & Itch Associates, Normal, IL, 2Asthma and Allergy Associates and Research Center, Colorado Springs, CO, 3Allergy and Asthma Medical Group and Research Center, San Diego, CA, 4Allergy & Asthma Specialists Medical Group, Huntington Beach, CA, 5Merck Research Laboratories, Kenilworth, NJ. 322 Reduction in Asthma Deteriorations in Subjects With Persistent Asthma Uncontrolled on Low-, Medium-, or High-Dose Inhaled Corticosteroids: A Pooled Analysis From Three Clinical Trials Using Combined Mometasone Furoate/Formoterol S. F. Weinstein1, R. A. Nathan2, E. O. Meltzer3, D. Gates4, H. Nolte4; 1Allergy and Asthma Specialists Medical Group and Research Center, Huntington Beach, CA, 2Asthma & Allergy Associates,

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

P.C. and Research Center, Colorado Springs, CO, 3Allergy and Asthma Medical Group and Research Center, San Diego, CA, 4Merck Research Laboratories, Kenilworth, NJ. 323 Effect of Budesonide/Formoterol Pressurized Metered-Dose Inhaler (BUD/FM pMDI) on Proportion of the Mean Peak Forced Expiratory Volume in 1 Second (FEV1) Over Time in Patients With Chronic Obstructive Pulmonary Disease or Persistent Asthma F. Ahmad, J. G. Zangrilli, U. J. Martin; AstraZeneca LP, Wilmington, DE. 324 Inhibitory Effect of Constituents Isolated from Ganoderma lucidum on LPS-stimulated Macrophages TNF-a Production Y. Chuang, C. Liu, N. Yang, Y. Song, B. Liang, X. Li; Pediatric Allergy & Immunology, The Mount Sinai School of Medicine, New York, NY.

Immunodeficiency and Basic Immunology 3203 Session Time: Sunday, March 20, 2011 9:45:00 AM - 10:45:00 AM

325 Successful Treatment of Acute Hemorrhagic Leukoencephalitis, a Novel Phenotype for Complement Factor I Deficiency L. Broderick, C. Gandhi, J. L. Mueller, C. D. Putnam, K. Shayan, K. S. Peterson, S. S. Aceves, R. M. Sheets, B. M. Peterson, R. O. Newbury, H. M. Hoffman, J. F. Bastian; University of California, San Diego, San Diego, CA. 326 Complement C6 Null Mutations in Extreme Prematurity T. P. Atkinson1, N. Ambalavanan1, R. A. Kaslow1, M. PeraltaCarcelen1, S. S. Cosby1, V. A. Phillips1, C. Li2, Y. Dai1; 1University of Alabama at Birmingham, Birmingham, AL, 2State Perinatal Program, Alabama Dept of Public Health, Montgomery, AL. 327 Association Of Mannose Binding Lectin (MBL) Gene Mutations With Other Pathway Defects Spanning Innate And Adaptive Immune Responses M. B. Pate, S. Wilgenbusch, D. S. Chi, G. Krishnaswamy; Quillen College of Medicine, Johnson City, TN. 328 Phenotypic Variations in Patients with Profound Mannose Binding Lectin Deficiency M. Rasheed, J. Shliozberg, A. Rubinstein; Albert Einstein - Montefiore Medical Center, Bronx, NY. 329 Early onset of Varicella Zoster Virus Reactivation (VZV, Shingles) in Patients with Autosomal Dominant Hyper IgE Syndrome (AD-HIES) J. Heimall1, A. M. Siegel2, P. A. Shaw2, A. Hsu2, S. M. Holland2, A. F. Freeman2, J. D. Milner2; 1The Children’s Hospital of Philadelphia, Philadelphia, PA, 2National Institutes of Health, Bethesda, MD. 330 Hyper-IgM Syndrome Due to CD40 Deficiency: Report of 10 Patients B. K. Al Saud1, Z. Al-Sum1, A. Al-Ghonaium1, S. Al-Muhsen1,2, H. Al-Dhekri1, R. Arnaout1, H. Al-Mousa1; 1King Faisal Specialist Hospital & Research Center, Riyadh, SAUDI ARABIA, 2King Saud University, Riyadh, SAUDI ARABIA. 331 Idiopathic CD4+ Lymphocytopenia: Clinical and Autoimmune Phenotype J. W. Leiding1, J. Heimall2, Y. Song3, S. M. Holland1, R. M. Siegel3, A. F. Freeman1; 1National Institute of Allergic and Infectious Diseases, Bethesda, MD, 2The Children’s Hospital of Philadelphia, Philadelphia, PA, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD.

332 Novel Mutation in Syntaxin-Binding Protein 2 (STXBP2) in Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL-5) Prevents IL-2-induced Natural Killer Cell Cytotoxicity and Degranulation R. W. Saltzman1, L. Monaco-Shawver2, K. E. Sullivan1, J. S. Orange1; 1The Children’s Hospital of Philadelphia, Philadelphia, PA, 2The Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA. 333 Clinical Conditions Associated with PCP in Children S. Albin, R. W. Saltzman, P. Russo, K. E. Sullivan; Children’s Hospital of Philadelphia, Philadelphia, PA. 334 Primary Immunodeficiencies in Brazilian patients younger than five years old M. B. Dorna1, L. A. Watanabe1, A. B. F. Fomin1, A. C. Pastorino1, C. M. A. Jacob1, C. A. A. Silva1, D. M. Vasconcelos2, M. M. S. Carneiro-Sampaio1; 1DEPT. OF PEDIATRICS, Faculdade de Medicina da Universidade de São Paulo, São Paulo, BRAZIL, 2DEPT. OF DERMATOLOGY, Faculdade de Medicina da Universidade de São Paulo, São Paulo, BRAZIL. 335 Approximation of Splenic NK and Dendritic Cells in PerforinDeficient Hemophagocytic Syndrome: Insights into Pathogenesis M. D. Keller, M. E. Paessler, J. Orange; Children’s Hospital of Philadelphia, Philadelphia, PA. 336 Review of Primary Immune Deficiency Disease Diagnosis Before and After Genetic Testing D. seth, R. Zeballos-Chavez, E. Secord; Wayne state university/Detroit medical center, Detroit, MI. 337 What Are Appropriate Antigens And Method For In Vivo Assessment Of Cell-Mediated Immunity In Children? P. Rattanasukol, K. Lertdumrongluk, N. Voraphani, T. Intapuntee, J. Ngamphaiboon, P. Chatchatee; Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, THAILAND. 338 Zinc Levels and Oxidative Stress in Ataxia-telangiectasia Patients R. da Silva1,2, E. C. Santos-Valente1, R. O. S. Sarni1,3, B. T. CostaCarvalho1; 1Federal University of Sao Paulo - Sao Paulo, Brazil, Sao Paulo, BRAZIL, 2Federal University of Alfenas, Alfenas, BRAZIL, 3Medicine College ABC, Sao Paulo, BRAZIL. 339 Analytical And Clinical Validation Of A Diagnostic Test For Evaluation Of NK Cell Subsets And NKT Cells R. S. Abraham, X. Dong; Mayo Clinic, Rochester, MN. 340 Enteropathogenic Escherichia coli Tir Recruits the Cellular Tyrosine Phosphatase SHP1/2 to Suppress the Host Innate Immune Responses Y. Dapeng, G. Baoxue; Institute of Health Sciences, Shanghai Institutes for Biological Sciences, CAS and Shanghai Jiaotong University School of Medicine, Shanghai, CHINA. 341 Characterizing the Role of LGP2 in RLR Signaling and Anti-Viral Immunity S. A. Newbrough, T. Saito, M. Gale, Jr; University Of Washington, Seattle, WA. 342 A novel pathway for self-tolerance: AID and Somatic Hypermutation in the Human Fetus L. M. McWilliams1, M. Kuraoka2, G. H. Kelsoe2; 1Duke University Medical Center, Division of Pediatric Allergy & Immunology, Durham, NC, 2Duke University Medical Center, Department of Immunology, Durham, NC. 343 Early B Lineage Cells Display Class Switch Preference To Ige D. R. Wesemann1, C. Boboila2, M. Gallagher2, F. W. Alt2;

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1Brigham and Women’s Hospital, Boston, MA, 2Children’s Hospital Boston, Boston, MA. Prostaglandin I2 Receptor (IP) Signaling Inhibits TLR4 Cell Surface Expression and Reduces LPS-induced Lung Inflammation S. Toki1, W. Zhou 1, K. Goleniewska 1, G. A. FitzGerald 2, R. S. Peebles, Jr.1; 1Vanderbilt University, Nashville, TN, 2University of Pennsylvania, Philadelphia, PA. IL-10 Differentially Regulates Components of the TSLP Receptor Complex on Blood Dendritic Cells R. Agrawal, P. W. Wright, J. A. Woodfolk; University of Virginia, Charlottesville, VA. Soybean Isoflavones Regulate Dendritic Cell-mediated Effector Functions M. Masilamani, J. Wei, H. A. Sampson; Mount Sinai School of Medicine, New York, NY. Freshly Isolated CD11c+ mDC Express The TSLPR And Responds To TSLP While pDC And In Vitro Cultured MoDC Do Not P. A. Würtzen1, G. K. Koed1, G. Grauert1, D. Papazian1, S. Hansen2, K. Lund1; 1ALK-Abello, Hørsholm, DENMARK, 2University of Southern Denmark, IMB, Odense, DENMARK. Blocking Antigen Transport To Resident Lymph Node Dendritic Cells Prevents CD4+ T-cell Priming J. A. Steinberg, A. Mahajan, H. M. A. Simkins, T. M. Laufer; University of Pennsylvania School of Medicine, Philadelphia, PA. Serum Immunoglobulin Isotypes in Thai Children Determined by Nephelometry S. Benjaponpitak 1, R. Sitcharungsi 1, A. Pornvoranunt 2, W. Kamchaisatian1, S. Vilaiyuk1; 1 Division of Pediatric Allergy/Immunology/Rheumatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, THAILAND, 2Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, THAILAND. Clinical And Immune Expression Of Nuclear Factor Kappa Essential Modulator (NEMO) Missense Mutations Of NFKB In 3 Family Members S. Rasalingam1, M. J. Finegold2, L. Noroski1, C. Hanson1; 1Baylor College of Medicine, Department of Pediatrics, Allergy Immunology Section, Houston, TX, 2Baylor College of Medicine, Department of Pathology, Houston, TX. Increasing IgM Associated with Severe Autoimmunity and Lymphoproliferation in Common Variable Immunodeficiency C. S. Patel, D. F. LaRosa; University of Pennsylvania School of Medicine, Philadelphia, PA. Novel L670P Mutation In The Stat3 Gene Discovered In A 44 Year Old Male With Job’s Syndrome G. D. Marshall, S. A. Bozeman; University of Mississippi, Jackson, MS.

Asthma - and What’s in the Air 3204 Session Time: Sunday, March 20, 2011 9:45:00 AM - 10:45:00 AM

353 Association Between Asthma-related Emergency Department Visits, Asthma-related Hospital Admissions, And Airborne Pollen And Mold Concentrations In The Bronx, 2001-2008 S. P. Jariwala, J. Toh, A. Geevarghese, S. Reddy, D. Rosenstreich; Albert Einstein/Montefiore Medical Center, Bronx, NY.

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Abstracts  AB289

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB290 Abstracts

SUNDAY

354 Persistent Indoor Air Pollution Levels in the Homes of New York City Children over 4 to 5 years J. M. Camacho1, S. Hsu1, K. H. Jung1, K. M. Moors1, K. J. Bernabé1, P. L. Kinney2, S. N. Chillrud3, R. Whyatt2, L. A. Hoepner2, J. M. Ross3, F. Perera2, R. L. Miller1,2; 1Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8E, 630 W. 168 St. New York, New York 10032, New York, NY, 2Mailman School of Public Health, Department of Environmental Health Sciences, Columbia University, 60 Haven Ave., B-1 New York, New York 10032, New York, NY, 3Lamont-Doherty Earth Observatory, Columbia University, 61 Rt, 9W Palisades, New York 10964, New York, NY. 355 Maternal Smoking during Pregnancy, Prematurity and Recurrent Wheezing in Early Childhood R. G. Robison1, R. Kumar1, L. M. Arguelles1, X. Hong1, A. Bonzagni2, S. Apollon2, K. Ortiz2, C. Pearson2, H. Bauchner2, J. A. Pongracic1, X. Wang1; 1Children’s Memorial Hospital, Chicago, IL, 2Boston Medical Center, Boston, MA. 356 Predicted Pollen Information Differs With Actual Counts and Data From Thirteen National Allergy Bureau Stations J. J. Anderson1, D. Dalan2, D. Olgeirson2; 1Environmental Allergy Assays, London, ON, CANADA, 2Allergy & Asthma Care Center, Fargo, ND. 357 Impact Of Temperature And Rainfall On Airborne Juniper Pollen C. S. Barnes, M. Dhar, J. M. Portnoy; Children’s Mercy Hospital, Kansas City, MO. 358 Asthma Among Office Workers And Exposure To Chemical And Biological Indoor Pollutants J. L. M. Rios, J. L. Boechat, M. C. K. Ramos, R. R. Luiz, F. R. Aquino Neto, J. R. Lapa e Silva; Federal University of Rio de Janeiro, Rio de Janeiro, BRAZIL. 359 Fungal rRNA Sequencing of Indoor and Occupational Air Samples W. R. Rittenour1, A. Adhikari2, T. Reponen2, D. H. Beezhold1, B. J. Green1; 1National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, 2Department of Environmental Health, University of Cincinnati, Cincinnati, OH. 360 The Effect of Wind Direction and Speed on Black Carbon Concentrations in Northern Manhattan and the Bronx C. Spalding1, S. Hsu1, M. M. Patel2, K. M. Moors1, S. Chillrud3, C. M. Jusino4, P. M. Shepard4, R. L. Miller5; 1Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, 2U.S. Environmental Protection Agency, Durham, NC, 3Lamont -Doherty Earth Observatory, Columbia Presbyterian, Palisades, NY, 4WE ACT for Environmental Justice, Bronx, NY, 5Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, Mailman School of Public Health, Dept of Environmental Health Sciences, Dept of Pediatrics, Columbia University, New York, NY. 361 Nasal Symptoms in Smoking Induced Lung Disease U. Nihlén1, S. Frantz2, P. Wollmer2, L. Greiff3, M. Andersson4; 1Department of Respiratory Medicine and Allergology, Lund University, Lund, SWEDEN, 2Department of Clinical Physiology, Lund/Malmö, SWEDEN, 3Department of Ear, Nose and Throat diseases, Lund, SWEDEN, 4Department of Ear, Nose and Throat diseases, Lund/Malmö, SWEDEN. 362 The Relative Role of Early-Life Outdoor & Indoor Fungi in the Home and Wheeze in the First Year of Life

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

J. E. Sordillo 1, B. Behbod 2, E. B. Hoffman 2, S. Datta 1, M. L. Muilenberg3, J. A. Scott4, D. R. Gold1; 1The Channing Laboratory, Harvard Medical School, Boston, MA, 2Harvard School of Public Health, Boston, MA, 3University of Massachusetts, Amherst, MA, 4Dalla Lana School of Public Health, University of Toronto, Toronto, ON, CANADA. 363 Indoor Allergens Associated With Lower Risk Of Emergency Visit Due To Asthma Attack J. Meng1, B. Aubin2, C. Barnes1, L. J. Rosenwasser1; 1Children’s Mercy Hospital/UMKC SOM, Kansas City, MO, 2Children’s Mercy Hospital, Kansas City, MO. 364 Effects of Asian Sand Dust on Human Health and Allergic Symptom, Fukuoka, Japan R. Kishikawa1, T. Imai2, T. Ichinose3, Y. Okuno4, K. Arashidani5, M. Nishikawa6, T. Shimoda1, T. Iwanaga1; 1The Fukuoka National Hospital, Fukuoka, JAPAN, 2Jikei University, Chiba, JAPAN, 3Oita University, Oita, JAPAN, 4JRC college, Fukuoka, JAPAN, 5University of OEH, Fukuoka, JAPAN, 6NIE Sudies, Tokyo, JAPAN.

Drivers of Immunity 3205 Session Time: Sunday, March 20, 2011 9:45:00 AM - 10:45:00 AM

365 Neutrophil-derived Interferon g (IFNg) Controls Inducible Nitric Oxide Synthase (Nos2) During Pneumococcal Pneumonia E. A. Duncan, J. Martin, C. M. Doerschuk; University of North Carolina at Chapel Hill, Chapel Hill, NC. 366 Association between Phthalates Exposure and Cytokines Profile among Pre-school-aged Children N. Y. Hsu, H. W. Chang, J. Y. Wang, H. J. Su; College of Medicine, National Cheng Kung University, Tainan, TAIWAN. 367 Serum 25-Hydroxyvitamin D is Positively Associated with Enhanced Pnuemococcal Antibody Titers in Individuals with Atopic Conditions J. Lee1, H. Zhao1, Y. Fenta1, H. Kita2, R. Kumar2, Y. Juhn1; 1Pediatrics, Mayo clinic, Rochester, MN, 2Internal medicine, Mayo clinic, Rochester, MN. 368 Gender-specific Effect Of Overweight And Obesity On Airway Inflammation In Adults With Asthma M. Imaoka, T. Tanahashi, R. Kishikawa, T. Shimoda, T. Iwanaga; Fukuoka National Hospital, Fukuoka, JAPAN. 369 Assays of House Dust Immunostimulatory Activity Predict Reduced Allergic Risk K. Y. Tse1, H. Kim2, L. Levin2, G. LeMasters2, D. Bernstein2, A. Horner1; 1University of California at San Diego, San Diego, CA, 2University of Cincinnati, Cincinnati, OH. 370 Effects of Mesenchymal Stem Cells on Pollen-Induced Lymphocyte Proliferation in Subjects with Allergic Rhinitis: Implications of Stem Cell Activity on Immune Response to Pollen M. Desai, E. Capitle, S. Patel, P. Rameshwar; University of Medicine and Dentistry of New Jersey, Newark, NJ. 371 Indoor Dust Derived Extracellular Vesicles Induce Chronic Lung Inflammatory Diseases Mediated By Th17 Immune Response Y. Kim1, W. Lee1, S. Choi1, B. Lee2, Y. Kim1; 1 POSTECH, Pohang/Gyungbuk, KOREA, REPUBLIC OF, 2Sungkyunkwan University College of Medicine, Seoul, KOREA, REPUBLIC OF.

Abstracts  AB291

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

Urticaria and Angioedema

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3206 Session Time: Sunday, March 20, 2011 9:45:00 AM - 10:45:00 AM

372 Idiopathic Angioedema and Coagulation Factor XII Mutation G. Dewald1, E. Aygören-Pürsün2, I. Martinez Saguer2, E. Rusicke2, W. Kreuz2; 1Institute for Molecular and Preventive Medicine, Koenigswinter, GERMANY, 2University Hospital Frankfurt, Pediatric Hematology and Oncology, Frankfurt/M., GERMANY. 373 Efficacy and Tolerability of Icatibant Acetate in Hereditary Angioedema due To C1 Inhibitor Deficiency (HAE): a Descriptive Study. N. Prior, M. Caminoa, C. Gómez- Traseira, M. López-Serrano, T. Caballero; Hospital La Paz Health Research Institute (IdiPaz), Madrid, SPAIN. 374 Icatibant, a Selective Bradykinin-B2 Receptor Antagonist, in Acquired Angioedema Due to C1 Inhibitor Deficiency K. Bork; University of Mainz, Mainz, GERMANY. 375 Treatment Patterns of Patients with Chronic Idiopathic Urticaria M. S. Broder1,2, E. Chang1, J. Zazzali3; 1PHAR, LLC, Beverly Hills, CA, 2UCLA School of Medicine, Los Angeles, CA, 3Genentech, South San Francisco, CA. 376 Drug-Induced Acute Urticaria in Children R. Sitcharungsi 1 , C. Marukatat 2 , A. Chunharas 2 , W. Kamchaisatian1, S. Vilaiyuk1, S. Benjaponpitak1; 1 Division of Pediatric Allergy/Immunology/Rheumatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, THAILAND, 2Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, THAILAND. 377 Prolonged Use of Omalizumab in Refractory Chronic Urticaria (CU) S. B. Regan, D. A. Khan; UT-Southwestern, Dallas, TX. 378 Xolair (omalizumab) in Treatment of Severe Refractory Chronic Idiopathic Urticaria G. Sussman1, N. Leader1, E. Merman1, R. Melvin2; 1University of Toronto, Toronto, ON, CANADA, 2University of Western Ontario, London, ON, CANADA. 379 Clinical Outcomes With Recombinant Human C1 Inhibitor In The Repeat Treatment Of Acute Attacks Of Hereditary Angioedema In North-american Patients B. Zuraw1, T. Craig2, R. F. Lockey3, M. Park4, J. Grant5, D. Suez6, L. B. Schwartz7, M. Riedl8, R. J. Levy9, H. H. Li10, L. Edara11, J. A. Bernstein12, J. Moy13, J. Offenberger14, A. Szema15, A. Engler16, S. M. Rehman17, T. C. Marbury18, O. Alpan19, S. L. Bahna20, A. Davis21, G. Sussman22, W. H. Yang23, B. Ritchie24, A. Relan25; 1University of California San Diego, San Diego, CA, 2Penn State University, Hershey, PA, 3University of South Florida, Tampa, FL, 4Mayo Clinic, Rochester, MN, 5University of Texas Medical Branch, Galveston, TX, 6Allergy. Asthma and Immunology Clinic P.A., Irving, TX, 7Virginia Commenwealth University, Richmond, VA, 8UCLA, Los Angeles, CA, 9Family Allergy & Asthma Center, Atlanta, GA, 10Institute for Asthma and Allergy, Wheaton, MD, 11 Asthma Allergy Centers of SW Michigan, Portage, MI, 12Bernstein Allergy group/Clinical Research Center, Cincinnati, OH, 13Rush University Medical Center, Chicago, IL, 14Allery & Asthma Institute of the Valley, Granada Hills, CA, 15SUNY Stony Brook School of Medicine, Stony Brook, NY, 16The Allergy and Asthma Clinic, San Mateo, CA, 17Asthma and Allergy Center, Toledo, OH, 18Orlando Clinical Research Center, Orlando, FL,

Clinical Trials Center, Springfield, VA, State University Health Sciences Center, Shreveport, LA, 21Medical Research of Arizona, Scottsdale, AZ, 22Wellesley Central Health Corporation, West Toronto, ON, CANADA, 23Allergy and Asthma Research Center, Ottawa, ON, CANADA, 24University of Alberta, Edmonton, AB, CANADA, 25Pharming Technologies BV, Leiden, NETHERLANDS. Effect of Anti-Ecallantide Antibodies on Tissue Factor Pathway Inhibitor Function D. Martik, G. Conley, J. Chen, S. R. Comeau, D. J. Sexton, C. Tenhoor; Dyax Corp., Cambridge, MA. Definitive Link of Mutation c.351delC and Development of Hereditary Angioedema in a Large Brazilian Family M. F. Ferraro1, A. S. Moreno1, E. Castelli1, A. P. Lange1, E. A. Donadi1, K. Bork2, W. Sarti1, L. K. Arruda1; 1School of Medicine of Ribeirao Preto, Ribeirao Preto, BRAZIL, 2Johannes-Gutenberg University, Mainz, GERMANY. Lack of Evidence for Activation of the Inflammasome in Typical Physical Urticarias H. D. Komarow1, B. Yang2, C. Nelson1, M. Young1, M. O’Brien1, N. Medic1, S. Chew1, J. Milner1, M. Gadina2, D. D. Metcalfe1; 1Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD, 2Office of Science and Technology, NIAMS, NIH, Bethesda, MD. Chronic Urticaria Related to Menses A. Shah, D. Resnick, R. L. Miller, S. M. Canfield; Columbia University, New York, NY. Diagnosis and Treatment of an American Cohort of Patients with Hereditary Angioedema (HAE) Type III E. Y. Wu, P. L. Lugar, M. M. Frank; Duke University Medical Center, Durham, NC. Characterization Of Subjects With Chronic Urticaria And Elevated Baseline Serum Tryptase R. I. Siles, F. H. Hsieh; Cleveland Clinic Foundation, Cleveland, OH. Case Series of Three Patients with Type III Hereditary Angioedema: Differences in Response to Treatment J. A. Cronin1,2, K. M. Maples1,2; 1Eastern Virginia Medical School, Norfolk, VA, 2Children’s Hospital of the King’s Daughters, Norfolk, VA. Phenotypic Profile of Potential Responders to Omalizumab in Chronic Idiopathic Urticaria R. K. Viswanathan1, M. J. Biagtan1, J. T. Kelly1, M. H. Moss1, S. K. Mathur1,2; 1University of Wisconsin School of Medicine & Public Health, Madison, WI, 2William S. Middleton Veterans Administration Hospital, Madison, WI. Assessment of Physician Knowledge of Hereditary Angioedema (HAE) and Its Treatments Before and After a Targeted Educational Event K. Todoric, Y. Powers, T. Craig; Penn State Milton S. Hershey Medical Center, Hershey, PA. Pharmacokinetic Berinert P Study Of Subcutaneous Versus Intravenous Administration In Subjects With Moderate Hereditary Angioedema - The Passion Study I. Martinez-Saguer 1 , M. Cicardi 2 , E. Aygören-Pürsün 1 , E. Rusicke1, T. Klingebiel1, W. Kreuz1; 11J.-W. Goethe University Hospital Frankfurt, Germany, Frankfurt, GERMANY, 2Università degli Studi di Milano, Dipartimento di Scienze Cliniche, Italy, ITALY. The Chronic Urticaria Index as a Predictor of Responsiveness to Therapy M. J. Biagtan1, R. K. Viswanathan1, S. K. Mathur1,2; 1University of Wisconsin Hospitals and Clinics, Madison, WI, 2William S. Middleton Veterans Administration Hospital, Madison, WI. 20Louisiana

AB292 Abstracts

392 Effect of Psychological Stress Intervention for Patients with Chronic Urticaria (CU) J. W. Tole, K. L. Gratz, N. D. Dave, S. K. Smith, G. D. Marshall; University of Mississippi Medical Center, Jackson, MS. 393 Angioedema Induced By Angiotensin-converting Enzyme Inhibitors: Two Cases Of Successful Treatment With A Novel B2 Bradykinin Antagonist D. V. Perez, S. Infante, G. Marco, J. M. Zubeldia; Hospital General Universitario Gregorio Marañon, Madrid, SPAIN. 394 Angiotensin-converting Enzyme Inhibitor And Angiotensin II Receptor Blocker-Induced Angioedema: Overuse of Ineffective Treatment M. Nasir, G. Sharma; UTMB-Galveston, Galveston, TX.

SUNDAY

Eosinophilic Gastrointestinal Disorders & Food Allergy 3207 Session Time: Sunday, March 20, 2011 9:45:00 AM - 10:45:00 AM

395 Endoscopic Findings in Children Who Present with Food Refusal P. B. M. Jhaveri1,2, P. N. Jhaveri3, A. Darbari3; 1Penn State Hershey Medical Center, Hershey, PA, 2Kennedy Krieger Institute, Baltimore, MD, 3Johns Hopkins University, Division of Pediatric Gastroenterology, Baltimore, MD. 396 Common Features of Feeding Difficulties (FD) Encountered in Children with Eosinophilic Gastrointestinal Diseases (EGIDs) N. C. Maune1, G. T. Furuta1,2, D. Atkins1,2, M. Henry1, Z. Pan1, A. M. Haas1; 1The Children’s Hospital, Aurora Colorado, Aurora, CO, 2National Jewish Health, Denver, CO. 397 Peanut Allergen Exposure Promotes Eosinophilic Esophagitis (EE) In Mice. M. Rayapudi, P. Rajaveylu, S. Narayanan, A. Mishra; Cincinnati Children’s Hospital, Cincinnati, OH. 398 Psychosocial Functioning in Children and Adolescents with Eosinophilic Esophagitis (EoE) and Their Families R. F. Harris1, N. Riechers1, G. T. Furuta2, D. Atkins1, M. D. Klinnert1; 1National Jewish Health, Denver, CO, 2The Children’s Hospital, Aurora, CO. 399 The Pan-B Cell Marker CD22 (siglec 2) Is Expressed On Gastro-intestinal (GI) Eosinophils And Negatively Regulates GI Eosinophil Survival T. Wen1, C. Blanchard1, B. Wahl2, O. Pabst2, M. E. Rothenberg1; 1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Institute of Immunology, Hannover Medical School, Hannover, GERMANY. 400 Allergic Component of Adult Eosinophilic Esophagitis K. N. Cahill1, J. Sheikh2; 1Brigham and Women’s Hospital, Boston, MA, 2Beth Israel Deaconess Medical Center, Boston, MA. 401 Dietary Adherence in Food Allergic Children with Eosinophilic Gastrointestinal Diseases M. Henry1, D. Atkins2, Z. Pan3, J. Ruybal3, W. Moore3, G. T. Furuta1; 1The Children’s Hospital, Aurora, CO, 2National Jewish Health, Denver, CO, 3University of Colorado, Aurora, CO. 402 Eosinophilic Esophagitis: Allergological-clinical Descriptive Study N. Cancelliere, A. Fiandor, M. Caminoa, t. Valvuena, M. Martinez, S. Quirce, T. Caballero; Hospital La Paz, Spain, SPAIN.

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

403 Vitamin D Levels In Children With Eosinophilic Esophagitis and Gastroesophageal Reflux K. Waterhouse, A. Katta, J. Teckman, T. Foy, J. Derdoy, A. Jain, A. Knutsen, B. Becker; St Louis University, St Louis, MO. 404 Visceral Larva Migrans due to Toxocara canis is the Most Common Cause of Eosinophilic Liver Abscess B. Lee1, J. Lee1, E. Kim1, K. Ha2, D. Choi1; 1Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KOREA, REPUBLIC OF, 2Chungju Hospital, Konkuk University, Chungju, KOREA, REPUBLIC OF. 405 Four Clusters were Identified in Abruptly-Increasing Neonates and Infants with Food Protein-Induced Gastrointestinal Syndrome, A Report of Japanese Patients I. Nomura1, H. Morita1, N. Ito1, T. Fukuie1, N. Ohtsuka2, S. Hosokawa2, M. Watanabe2, A. Terada2, H. Hoshina2, T. Takamasu2, Y. Ohya1, H. Saito1, K. Matsumoto1; 1National Center for Child Health and Development, Tokyo, JAPAN, 2Japanese Research Group for Neonatal, Infantile Allergic Disorders, Tokyo, JAPAN. 406 Eosinophilic Cholangiopathy Presenting With Peripheral Eosinophilia and Hepatic Mass M. Ling, J. Begun, S. Patil, D. L. Hamilos; Massachusetts General Hospital, Boston, MA. 407 Eosinophilic Esophagitis and IgE Mediated Allergy in Children: Detection of Specific IgE by a Microarray-Based assay (MBa) G. Cavagni, P. De Angelis, L. E. D’Urbano, K. Pellegrino, F. Rea, C. Riccardi, F. Torroni, R. Luciano, F. De Benedetti, L. Dall’Oglio; I.R.C.C.S. Children’s Hospital “Bambino Gesù”, Rome, ITALY. 408 Food Sensitization Is Prevalent in Adults With Eosinophilic Esophagitis S. Gottlieb1, B. Green2, R. Sadurski2, M. Bachinski2, A. Ramage2, W. Gilchrist2; 1Carolina Allergy, Sinus & Asthma, Greenwood, SC, 2Digestive Disease Group, Greenwood, SC. 409 Eosinophilic Esophagitis In Adults: Allergy Study R. Lleonart, J. Botargues, E. Muñoz, M. Corominas; Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, SPAIN. 410 Differential Effect of Swallowed Inhaled Corticosteroids on Eosinophilic Infiltration of the Proximal vs the Distal Esophagus in Eosinophilic Esophagitis J. T. Stribling, C. Uram-Tuculescu, M. Abu-Shukair, A. M. Irani; Virginia Commonwealth University, Richmond, VA. 411 Exhaled Nitric Oxide as a Screening Tool for Eosinophilic Esophagitis in Children M. J. Lanz1,2, R. Gonzalez Vallina2, A. P. Bautista1, R. A. Guerrero3; 1AAADRS Clinical Research Center, Coral Gables, FL, 2Miami Childrens Hospital, Miami, FL, 3Childrens Gastroenterology of South Florida, Loxahatchee, FL. 412 Management of Eosinophilic Esophagitis in a Consecutive Series of Pediatric Patients in an Australian Tertiary Referral Centre M. Nethercote1, R. Heine1,2,3,4, N. Osborne1,2, L. Stevens5, D. Davidson5, K. Allen1,2,3,4; 1Murdoch Childrens Research Institute, Melbourne, AUSTRALIA, 2Dept of Paediatrics, University of Melbourne, Melbourne, AUSTRALIA, 3Dept of Gastroenterology & Clinical Nutrition, Royal Children’s Hospital, Melbourne, AUSTRALIA, 4Dept of Allergy & Immunology, Royal Children’s Hospital, Melbourne, AUSTRALIA, 5Dept of Anatomical Pathology, Royal Children’s Hospital, Melbourne, AUSTRALIA.

413 Racial Disparities in the Presentation of Pediatric Eosinophilic Esophagitis H. P. Sharma1, D. K. Mansoor1, A. C. Sprunger1, K. Zalos1, H. Taylor1, X. Martin1, I. J. Mikhail2; 1Children’s National Medical Center, Washington, DC, 2National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. 414 The Diagnosis of Food Allergies in Eosinophilic Esophagitis Patients in an Urban Medical Center A. Kewalramani, M. E. Bollinger, C. Vibbert; University of Maryland School of Medicine, Baltimore, MD. 415 Impact of Eosinophilic Esophagitis (EoE) on Quality of Life (qol) for Youth and Their Families M. Klinnert1, W. Moore2, J. Miller1, D. Atkins1, D. Fleischer1, G. T. Furuta2; 1National Jewish Health, Denver, CO, 2The Children’s Hospital, Aurora, CO. 416 Identification of Tamarillo (Cyphomandra betacea) Allergens R. Tiwari, F. M. Wolber; Massey University, Palmerston North, NEW ZEALAND. 417 Assessing the Impact of an Educational Intervention Upon the Quality of Life of Food Allergic Children P. Paranjpe, D. Schull, J. A. Bird; UT-Southwestern Medical School, Dallas, TX. 418 IgE Binding Areas with Similar Physicochemical Properties Mediate Cross-Reactivity Between Peanut and Tree Nut Allergens S. J. Maleki1, S. S. Teuber2, H. Cheng1, C. H. Schein3; 1US Dept. of Agriculture, New Orleans, LA, 2UC Davis School of Medicine, Davis, CA, 3University of Texas Medical Branch, Galveston, TX. 419 Does Early H2 Blocker Use Promote Food Allergy in Children? C. Savides1,2, K. A. Homa2, D. A. Gruenberg2,1, M. S. Shaker1,2; 1Children’s Hospital at Dartmouth, Lebanon, NH, 2DartmouthHitchcock Medical Center, Lebanon, NH. 420 Associated Factors for the Persistence of IgE-mediated Cow`smilk Allergy F. J. RUANO, N. BLANCA-LOPEZ, M. I. GARCIMARTIN, M. VAZQUEZ DE LA TORRE, R. BARRANCO, E. SEOANE, G. CANTO; HOSPITAL INFANTA LEONOR, MADRID, MADRID, SPAIN. 421 The Challenge Of Using Information On Food Packaging To Avoid Peanut And Nut Allergens J. S. Lucas1, J. Barnett2, J. Leftwich3, K. Muncer3, R. Shepherd3, M. M. Raats3, M. Gowland4, K. Grimshaw1; 1University of Southampton, Southampton, UNITED KINGDOM, 2Brunel University, Uxbridge, UNITED KINGDOM, 3University of Surrey, Guildford, UNITED KINGDOM, 4Allergy Action/ Anaphylaxis Campaign, St Albans, UNITED KINGDOM. 422 Initial Characterization Of Two Pine Nut Seed Allergens B. Cabanillas1, C. C. Grimm2, J. F. Crespo1, A. Jimenez1, J. Rodriguez1, S. J. Maleki2; 1Hospital Universitario 12 de Octubre, Madrid, SPAIN, 2United States Department of Agriculture - Agricultural Research Service - Southern Regional Research Center (USDA-ARS-SRRC), New Orleans, LA. 423 Recombinant Ara h 6 derived from Pichia pastoris Resembles Native Ara h 6 in IgE cross-linking Activity Y. Zhuang, S. C. Dreskin, X. Chen; University of Colorado Denver, Division of Allergy & Clinical Immunology, Aurora, CO. 424 Potential Role of Interleukin-4 Secreting Non-T Cells in the Development of Food Allergy

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J. C. Caubet, M. Masilamani, L. Mayer, H. A. Sampson; Mount Sinai School of Medicine, New York, NY. Post-Solid Organ Transplant Atopy Is Not Limited to Food Hypersensitivity P. Shroff1, R. S. Mehta2, J. Chinen2, S. J. Karpen2, C. M. Davis2; 1Baylor College of Medicine, Dept. of Medicine, Section of Immunology, Allergy, and Rheumatology, Houston, TX, 2Baylor College of Medicine, Dept. of Pediatrics, Houston, TX. Relative and Absolute Quantitation of Ten Allergens in Twenty Commercial Soybean Varieties Using Tandem Mass Spectrometry N. L. Houston1, D. G. Lee1, S. E. Stevenson1, G. S. Ladics2, G. A. Bannon3, S. McClain4, L. Privalle5, N. Stagg6, C. HerouetGuicheney7, J. J. Thelen1; 1 University of Missouri, Columbia, MO, 2 Pioneer Hi-Bred International, Inc., Wilmington, DE, 3Monsanto Co., St. Louis, MO, 4Syngenta Biotechnology, Research Triangle Park, NC, 5 BASF Plant Science, Research Triangle Park, ND, 6 Dow AgroSciences, Indianapolis, IN, 7 Bayer SAS, Sophia, FRANCE. Molecular Characterization of Ara h 1 Before and After Thermal Processing C. P. Mattison1, C. C. Grimm1, H. Wei2, S. J. Maleki1; 1USDA-ARS-SRRC, New Orleans, LA, 2Waters Corp., Beverly, MA. Contribution of Ara h 2 and Ara h 6 to the Effector Activity of Crude Peanut Extract X. Chen, Q. Wang, S. Dreskin; University of Colorado - Denver, Aurora, CO. Basal Cell Hyperplasia as a Surrogate Marker for Subepithelial Fibrosis in Pediatric Eosinophilic Esophagitis K. M. Maples 1,2, J. Grubert 1,2, S. Poff 1,2, M. Aguiar 1,2, E. McGuire1,2, S. Ebmeier1,2, A. Fantaskey1, S. Stanley1, L. Willis1,2; 1Eastern Virginia Medical School, Norfolk, VA, 2Children’s Hospital of The Kings’ Daughters, Norfolk, VA. Safe Administration of Flu Vaccine in Egg Allergic Patients S. R. Boden, V. S. LaBelle, D. A. Sedlak, E. H. Kim, B. P. Vickery, A. W. Burks; Duke University, Durham, NC. Risk Assessment of Soy Commodity Contamination in Wheat Flour B. Remington, J. L. Baumert, D. B. Marx, S. L. Taylor; University of Nebraska, Lincoln, NE.

Under-Served Populations, Epidemiology and Health Economics 3208 Session Time: Sunday, March 20, 2011 9:45:00 AM - 10:45:00 AM

432 High Prevalence of Exercise-Induced Bronchospasm, Obesity and Environmental Tobacco Smoke Exposure Among Asthmatic Children from Rural Southwestern PA D. Gentile1, W. Hanlon2, D. Skoner1; 1 Allegheny General Hospital, Pittsburgh, PA, 2 St. Francis University, Loretto, PA. 433 Increased Prevalence of Autoimmune Complications in Patients Diagnosed with Common Variable Immunodeficiency J. W. Verbsky1, P. O. Bonnet2, Y. Xiong2, W. J. Grossman2; 1 Medical College of Wisconsin, Milwaukee, WI, 2 Baxter Healthcare Corporation, Westlake Village, CA.

SUNDAY

Abstracts  AB293

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB294 Abstracts

SUNDAY

434 Correlation between Demographic Characteristics and Indoor Allergen Sensitization among a Farming Community (FC), a Local Community (LC), and an Urban Region (UR) in South Korea K. S. Park1, H. H. Jung1, J. W. Kwon2, S. Y. Lee3, S. Hong2; 1Presbyterian Medical Center, Jeonju, KOREA, REPUBLIC OF, 2 Asan Medical Center, Seoul, KOREA, REPUBLIC OF, 3 Pyeongchon Sacred Heart Hospoital, Anyang, KOREA, REPUBLIC OF. 435 Cost-Of-Illness Survey Of Patients With Food Hypersensitivity In Germany V. König1,2, N. Rösch2, R. Mösges1, P. Schmalz1, S. Kohler2, A. Arens-Volland2, R. Herbst2, S. Schnadt3; 1Institute of Medical Statistics, Informatics and Epidemiology, Cologne, GERMANY, 2Centre de Recherche Public Henri Tudor, Kalchesbrueck, LUXEMBOURG, 3German Allergy and Asthma Association, Monchengladbach, GERMANY. 436 Prevalence of Immigrants and Characterization of 2008 and 2009 Patients at an Allergy Clinic of a Public Hospital in Madrid C. Alava, D. Perez, C. Sost, E. Rodriguez, M. Baeza; Hospital General Universitario Gregorio Marañon, Madrid, SPAIN. 437 Lower Prevalence of Allergic Diseases in Korean Rural Children is Associated with Farming Environment and Rural Lifestyle S. Lee1, J. Kwon2, J. Seo2, Y. Song2, B. Kim3, J. Yu2, G. Park4, H. Kim5, S. Hong2; 1Department of Pediatrics, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang, KOREA, REPUBLIC OF, 2Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KOREA, REPUBLIC OF, 3Department of Pediatrics, Inje University Haeundae Paik Hospital, Pusan, KOREA, REPUBLIC OF, 4Department of Pediatrics, Jeon-Ju Jesus Hospital, Jeonju, KOREA, REPUBLIC OF, 5School of Public Health, Seoul National University, Seoul, KOREA, REPUBLIC OF. 438 High Prevalence of Asthma, Obesity and Hypertension in Children from Pittsburgh’s Inner-City J. Padden1, N. Marcotullio1, D. Gentile2, D. Skoner2; 1Duquesne University School of Pharmacy, Pittsburgh, PA, 2Allegheny General Hospital, Pittsburgh, PA. 439 Recent Trends in Asthma Mortality in Ohio and Cuyahoga County: African Americans and Residents of Poverty Areas Remain Disproportionately Burdened S. K. Silvers1, M. Xu1, D. R. Stukus2, D. M. Lang1; 1Cleveland Clinic Foundation, Cleveland, OH, 2Children’s Hospital of Pittsburgh, Pittsburgh, PA. 440 Prevalence Of Positive Atopy Patch Test In A Pediatric Population N. FUIANO1, S. Fusilli2, C. Incorvaia3; 1ASL Foggia, SAN SEVERO, ITALY, 2Health Service IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, ITALY, 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milano, ITALY.

Asthma Therapy, Health Behavior and Education, and Health Policy 3209 Session Time: Sunday, March 20, 2011 9:45:00 AM - 10:45:00 AM

441 Education of Proper Technique of Respiratory Devices: A Survey of Pharmacists N. Baman, T. Craig; Pennsylvania State University Milton S. Hershey Medical Center, Hershey, PA.

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

442 Efficiency Of Test For Respiratory And Asthma Control In Kids Aged 1-5 Years (TRACK) By Guardian Compared With Doctor In Thai Children C. Saowapark, G. Phongsamart, M. Vangweerawong; Queen Sirikit National Institute of Child Health, Bangkok, THAILAND. 443 The Educational Program On The Inhalation Technique In A Group Of Patients With Asthma And Copd Using Aerolizer The Effectiveness And The Patients’ Satisfaction I. Kuprys-Lipinska1, K. Wiacek2, R. Przyrowski2, P. Kuna1; 1N. Barlicki Memorial University Teaching Hospital, Lodz, POLAND, 2Novartis, Warsaw, POLAND. 444 A Cross Sectional Survey Of Inhaler Technique And Training Among Dundee Medical Students P. A. Williamson, L. McKinlay, B. Ho, A. Y. Mohammed, B. J. Lipworth; UNIVERSITY OF DUNDEE, DUNDEE, UNITED KINGDOM. 445 Impact of Hazard Control over Risk Assessment on the Allergic Consumer: A FARRP study M. Costello1, S. Taylor2, J. O. B. Hourihane1, A. DunnGalvin1; 1University College Cork, Cork, IRELAND, 2University of Nebraska, Nebraska, NE. 446 Allergist-Immunologist perspectives on Primary Immunodeficiency in Brazil b. T. costa-carvalho1, d. sole1, f. sano2, N. Rosario3, a. condinoneto4, M. Boyle5, j. S. orange6; 1Federal University of Sao Paulo, sao paulo, BRAZIL, 2Hospital Nipo Brasileiro, sao paulo, BRAZIL, 3Federal University of Parana, Parana, BRAZIL, 4University of Sao Paulo, sao paulo, BRAZIL, 5Immune Deficiency Foundation, Towson, MD, 6University of Pennsylvania School of Medicine, Philadelphia, PA. 447 What Proportion of Paediatric Allergy Referrals Could Be Dealt With In Primary Care? T. Isinkaye1, S. Gilbert1, P. Seddon2, H. Smith1; 1Division of Primary Care and Public Health, Brighton and Sussex Medical School, BRIGHTON, UNITED KINGDOM, 2Department of Paediatrics, Brighton and Sussex University Hospitals Trust, BRIGHTON, UNITED KINGDOM. 448 Primary Immunodeficiencies (PID) - Driving Diagnosis for Optimal Care Globally R. U. Sorensen1, R. Hurtado2,3; 1LSUHSC, New Orleans, LA, 2Organization of the American States, Washington, DC, 3Georgetown University Medical School, Washington, DC.

Allergen Characterization 3210 Session Time: Sunday, March 20, 2011 9:45:00 AM - 10:45:00 AM

449 Production of Single Chain Variable Fragment Antibodies (scFv) for the Characterization of German Cockroach (GCr) Extracts M. Collison, T. Khurana, J. E. Slater; Laboratory of Immunobiochemistry/DBPAP/CBER/FDA, Bethesda, MD. 450 Identification of Novel Allergens of Blatella germanica using Single Chain Variable Fragment Antibodies T. Khurana1, M. Collison1, F. Chew2, J. E. Slater1; 1Laboratory of Immunobiochemistry/CBER/FDA, Bethesda, MD, 2Allergy and Molecular Immunology Laboratory/Department of Biological Sciences/National University of Singapore, Singapore, SINGAPORE. 451 Antigen 5 Allergen Content in Vespula and Polistes US Venom Extracts G. A. Plunkett1, R. I. Monslave2, M. L. Schell1;

1ALK-Abello,

Inc., Round Rock, TX, 2ALK-Abello, Madrid, SPAIN. 452 Lack of Standardization of Fungal Extracts Between Different Manufacturers Decreases the Reliability of Skin Testing for Fungal Species K. Z. Dhanani, R. K. Kado, W. E. Davis, L. G. Wild; Tulane University School of Medicine & Ochsner Clinic Foundation, New Orleans, LA. 453 Diagnostic Reliability Of The Component-based Allergenmicroarray In Grass, Cypress And Olive Pollens Allergy P. Cabrera-Freitag, M. Sanz, M. Goikoetxea, G. Javaloyes, F. Berroa, M. Ferrer; Clínica Universidad de Navarra, Pamplona, SPAIN.

Rhinosinusitis 3211 Session Time: Sunday, March 20, 2011 9:45:00 AM - 10:45:00 AM

454 Role of Local Immunoglobulin E Production in the Pathophysiology of Chronic Rhinosinusitis with Nasal Polyps and Allergic Fungal Rhinosinusitis Y. MATSUWAKI, T. Okushi, D. Asaka, N. Otori, H. Moriyama; Jikei university, school of medicine, Minato-ku, Tokyo, JAPAN. 455 Effectiveness of Mometasone Furoate Nasal Spray with or without Antibiotics vs. Antibiotic Monotherapy in Patients with Acute Rhinosinusitis in the United Kingdom E. M. Maiese1, C. de Moor2, G. Reardon3,4, J. McLaughlin3,4, P. Navaratnam2,4; 1Merck & Co., Inc., West Point, PA, 2DataMed Solutions, LLC, Hilliard, OH, 3Informagenics, Worthington, OH, 4The Ohio State University College of Public Health, Columbus, OH. 456 Demonstration Of A Common Genetic Basis To CRS In Chinese And Caucasian Populations Y. Zhang1, M. Desrosiers2, L. Mfuna-Endam3, A. Filali-Mouhim3, L. Zhang1; 1Key Laboratory Otolaryngology Head and Neck Surgery, Ministry of Education of China, Beijing Institute of Otolaryngology, Beijing, CHINA, 2Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montréal, QC, CANADA, 3Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, QC, CANADA. 457 Evaluation Of The Nasal No Response To Humming As An Index Of Osteo-meatal Patency: A Comparison With Sinus CT Measurements D. Shusterman1, E. M. Weaver2, A. N. Goldberg1, S. F. Schick1, H. Wong1, J. R. Balmes1; 1University of California, San Francisco, San Francisco, CA, 2University of Washington, Seattle, WA. 458 A New Method For Cell Isolation Reveals Elevated Numbers of T and B Lymphocytes In Sinonasal Tissue From Patients With Chronic Rhinosinusitis K. E. Hulse1, J. Norton1, K. Harris1, D. Conley2, R. Chandra2, R. Kern2, A. Peters1, L. Grammer1, B. Tan2, R. Carter1, L. Suh1, R. Schleimer1; 1Division of Allergy-Immunology, Department of Medicine, Northwestern University, Chicago, IL, 2 Department of Otolaryngology-Head and Neck Surgery, Northwestern University, Chicago, IL. 459 Systemic Corticosteroids Reduce Peripheral Blood Regulatory T Cells in Chronic Rhinosinusitis (CRS): A Controlled Trial S. Watanabe1,2, S. Sharma3, M. E. Bashir1, M. DeTineo1, F. M. Baroody1, R. M. Naclerio1, J. M. Pinto1; 1The University of Chicago, CHICAGO, IL, 2Showa University, Tokyo, JAPAN, 3University of Michigan, Ann Arbor, MI.

460 Categorization of Complications of Allergic Fungal Sinusitis S. A. Bozeman, R. deShazo, S. Stringer, L. Wright; University of Mississippi, Jackson, MS. 461 Correlation Between Sinus Scoring And Nasal Nitric Oxide In Nasal Polyp Disease S. Vaidyanathan, L. McKinlay, P. A. Williamson, B. J. Lipworth; UNIVERSITY OF DUNDEE, DUNDEE, UNITED KINGDOM. 462 Intranasal Eosinophilic Major Basic Protein May Have A Role As A Biological Marker For Chronic Rhinosinusitis With Nasal Polyps M. K. Elias, D. Squillace, H. Kita; Mayo Clinic, Rochester, MN. 463 Measurement of Mycotoxins in Patients with Chronic Rhinosinusitis S. M. Lieberman, J. B. Jacobs, R. A. Lebowitz, B. A. Feigenbaum; New York University School of Medicine, New York, NY. 464 Role Of CT Imaging In Management Of Acute Sinusitis M. H. Bashir1, P. Buddiga2, M. N. Baz2; 1University of California San Francisco Fresno Education Program, Fresno, CA, 2Baz Allergy, Asthma and Sinus Center, Fresno, CA. 465 Pediatric Allergic Fungal Sinusitis with Intracranial Extension - A Case Series J. Shih, K. Demuth; Emory University, Atlanta, GA. 466 Prophylaxis of Nasal Polyposis After Response to Treatment With Mometasone Furoate Nasal Spray C. B. Small 1, A. Moscatello 1, A. Damiano 1, A. Teper 2, G. Gopalan3; 1New York Medical College, Valhalla, NY, 2Merck Research Laboratories, Kenilworth, NJ, 3Merck & Co., Kenilworth, NJ.

Cytokines and Atopic Disease 3212 Session Time: Sunday, March 20, 2011 9:45:00 AM - 10:45:00 AM

467 IL-33 Is As Potent And Effective As IL-5 In Enhancing Siglec8-mediated Apoptosis Of Human Eosinophils In Vitro H. J. Na, S. H. Hudson, B. S. Bochner; Johns Hopkins University, Baltimore, MD. 468 The Danger Signal, Extracellular ATP, is a Sensor for Airborne Allergens and Triggers IL-33 Release and Innate Th2-type Responses H. Kouzaki1,2, K. Iijima1, T. Kobayashi1, S. M. O’Grady3, H. Kita1; 1Mayo clinic, Rochester, MN, 2Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Shiga, JAPAN, 3Departments of Integrated Biology and Physiology and Animal Science, University of Minnesota, St. Paul, MN. 469 Role of CD8+ Effector Memory T Cell-Derived IL-6 in the Development of Airway Hyperresponsiveness and Inflammation Y. Jia, K. Takeda, J. Han, A. Joetham, J. J. Lucas, E. W. Gelfand; National Jewish Health, Denver, CO. 470 IL-17A Directly Enhances IL-13-driven Stat6 Phosphorylation I. P. Lewkowich, M. Wills-Karp; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. 471 IL-17A Exacerbates Airway Hyperresponsiveness by Suppressing T regulatory Cell-Mediated Protection C. Buckingham, M. Wills-Karp; Cincinnati Children’s Hospital, Cincinnati, OH. 472 The Effect of IL-17 on Glucocorticoid Receptor [GR] Translocation C. Kirkland, L. Kaphalia, W. J. Calhoun; University of Texas, Galveston, TX.

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Abstracts  AB295

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AB296 Abstracts

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473 Oxidative Stress Inhibits Glucocorticoid Receptor Translocation into the Nucleus of Human Lung Fibroblast Cells K. Bhat, L. Kaphalia, W. Calhoun; University of Texas- Medical Branch, Galveston, TX. 474 Induction of Thymic Stromal Lymphopoietin (TSLP) in Airway Epithelium by Recombinant Allergens C. C. K. Hui1, D. M. Murphy2, B. Thong1, G. Delespesse3, J. A. Denburg1, M. Larché1,4; 1McMaster University, Hamilton, ON, CANADA, 2Cork University Hospital, Cork, IRELAND, 3CHUM Research Center, NotreDame Hospital, Montreal, QC, CANADA, 4Imperial College, London, UNITED KINGDOM. 475 Plasma Thymic Stromal Lymphopoietin Concentration is related to Allergen Sensitization in Young Children G. R. Bloomberg1, S. Demehri1, C. M. Visness2, G. O’Connor3, M. Kattan4, R. Wood5, J. E. Gern6, R. Kopan1; 1Washington University School of Medicine, St. Louis, MO, 2Rho Federal Systems Division, Inc.,, Chapel Hill, NC, 3Boston University School of Medicine, Boston, MA, 4Columbia University School of Medicine, New York, NY, 5Johns Hopkins University School of Medicine, Baltimore, MD, 6University of Wisconsin School of Medicine and Public Health, Madison, WI. 476 TSLP Enhances Barrier Function in Human Conjunctival Epithelial Cells E. B. Cook, J. L. Stahl, E. A. Schwantes, F. M. Graziano, S. K. Mathur; University Wisconsin, Madison, WI. 477 Effect of Thymic Stromal Lymphopoietin (TSLP) on Cord Blood (CB) Progenitor Cell Hemopoietic Cytokine Receptors (HCR). D. Heroux1, I. Asher1, J. Denburg1, G. Delespesse2, Z. Allakhverdi2; 1McMaster Universtiy, Hamilton, ON, CANADA, 2CRCHUM, Notre-Dame Hospital, Montreal, QC, CANADA. 478 Changes in CXCL9, CXCL10 and CXCL11 Concentrations after Nasal Allergen Challenge D. Tworek1, M. Bochenska-Marciniak1, I. Kuprys-Lipinska1, Z. Kurmanowska1, W. Mlynarski2, P. Gorski1, P. Kuna1, A. Antczak1; 1Barlicki University Hospital, Medical University of Lodz, Lodz, POLAND, 2Medical University of Lodz, Lodz, POLAND. 479 Interferon beta Expression is Attenuated In Human Model of Alternatively Activated Macrophages A. EL FIKY, R. Perreault, K. Kirschman, R. L. Rabin; FDA/CBER, BETHESDA, MD. 480 Expression of CGRP and its Functional Receptor Activity Modifying Protein (RAMP)-1 in Late-Phase Allergic Reactions in Atopics A. B. Kay, K. Bonner, P. Clark; Imperial College London, London, UNITED KINGDOM. 481 The Effect of Polycyclic Aromatic Hydrocarbons on Aryl Hydrocarbon Receptor and DNA Methyltransferase I Transcription L. Cachola, J. Liu, C. McDonald-Hyman, K. Nadeau; Stanford University, Stanford, CA. 482 MMP-2 Inhibition Attenuates IL-13 Induced Collagen Type-1 mRNA Expression in Human Airway Fibroblasts in Asthma R. Firszt, T. D. Church, D. Francisco, D. Beaver, J. L. Ingram, M. Kraft; Duke University Medical Center, Durham, NC. 483 Frequency Of Grass Pollen-specific Il-4, Il-10 And Dual Il-4 And Il10 Positive Cells In Atopic And Non-atopic Individuals In And Out Of The Pollen Season M. H. Shamji, A. Chaker, D. Cheung, M. Poon, C. SchmidtWeber, S. R. Durham, S. R. Durham; Imperial College London, South Kensington, UNITED KINGDOM.

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

484 In vivo Exposure of Mice to Alternaria Alternata Induces IL-18 Release into the Airways: A Cause of Allergic Asthma? H. Qi, H. Murai, A. Kalita, S. Sur; University of Texas Medical Branch, Galveston, TX. 485 Low Levels of Cytokines and Growth Factors in Serum of Allergic and Non-Allergic Top Atletes M. Bonini 1, B. Ruckert 2, D. Fioretti 3, C. Gramiccioni 3, V. Sargentini4, M. Rinaldi3, C. Akdis2, G. W. Canonica1, C. Tranquilli5, A. Pelliccia5, S. Bonini6; 1University of Genoa, Genoa, ITALY, 2Swiss Institute of Allergy and Asthma Research (SIAF), Davos, SWITZERLAND, 3Institute of Neurobiology and Molecular Medicine, National Research Council, Rome, ITALY, 4ASL RM-A, Rome, ITALY, 5Sports Medicine Institute, Italian National Olympic Committee, Rome, ITALY, 6Second University of Naples, Naples, ITALY. 486 Allergen-induced Ccl20 Release From Bronchial Epithelial Cells Requires Ion Transporter-mediated Chloride Export M. Webb, K. Dienger, M. Wills-Karp; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. 487 Inhibition Of Chemokine Secretion From Stimulated Airway Smooth Muscle (asm) By Glucocorticoids And Vitamin D Requires Vitamin D Receptor (vdr) Activation A. Banerjee, H. Fogle, R. A. Panettieri, Jr.; University of Pennsylvania, Philadelphia, PA. 488 Breast Milk Cytokines and Maternal Allergy J. L. Burch, N. Soto-Ramirez, W. Karmaus; University of South Carolina, Columbia, SC. 489 Involvement of Interleukin-17 in Oxazolone-induced Allergic Contact Dermatitis in Mice J. Hong, M. Kim, K. Lee, K. Kim, M. Sohn; Department of Pediatrics and Institute of Allergy, Severance Medical Research Institute, Brain Korea 21 Project for Medical science, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF. 490 Inflammatory Cytokines Analysis In The Tears In Sjogeren And Non-sjogren Dry Eye Patients K. Na, Y. Chun, J. Mok, C. Joo; The Catholic Univ. of Korea, Seoul, KOREA, REPUBLIC OF. 491 Variations in Human Rhinovirus (HRV)-induced Cytokine Release from Human Alveolar Macrophages Obtained from Individuals with Different Asthma Severity M. L. Gavala, M. E. Bates, M. D. Evans, W. W. Busse, P. J. Bertics; University of Wisconsin, Madison, WI. 492 Some Inflammatory Citokines in Nasopharyngheal Aspirates from Respiratory Syncytial Virus Infected Infants remain Increased Independantly from the Presence of the Virus P. V. Díaz, R. A. Pinto, A. Goecke, A. A. Gaggero; Faculty of Medicine, ICBM, University of Chile, Santiago, CHILE.

Mast Cells and Mast Cell Disease 3213 Session Time: Sunday, March 20, 2011 9:45:00 AM - 10:45:00 AM

493 Activated Mast Cells Instruct Bone Marrow to Produce Effector Cells of Allergic Response Z. Allakhverdi1, M. R. Comeau2, G. Delespesse1; 1CHUM Research Center, Notre-Dame Hospital, Montreal, QC, CANADA, 2Amgen Inc, Seattle, WA. 494 Sputum Mast Cell Markers Reflect Invasive Measures and Represent a Noninvasive Biologic Marker of Asthma Control and Severity M. L. Fajt 1 , S. Balzar 1 , J. F. Alcorn 2 , J. B. Trudeau 1 , S. E. Wenzel1;

Abstracts  AB297

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Oral Abstract Session Predicting Asthma 3601 Session Time: Sunday, March 20, 2011 2:00:00 PM - 3:15:00 PM

503 Is Exhaled Nitric Oxide (FeNO) Elevated in Children with Acute Asthma? J. Malka, J. R. Fish, P. Pickering, P. Ramamoorthy, M. Gleason, J. D. Spahn; National Jewish Health, Denver, CO. 504 Magnetic Resonance Imaging (MRI) Technique Detects Differences in Lung Function in Boys and Girls who are at Risk for Asthma E. L. Anderson1, M. D. Evans2, L. P. Salazar1, C. J. Tisler1, K. A. Roberg1, R. Gangnon2, D. J. Jackson1, J. E. Gern1, R. Lemanske, Jr.1, S. B. Fain3;

1University

of Wisconsin School of Medicine and Public Health, Madison, WI, 2University of Wisconsin Population Health Sciences Biostatistics and Medical Informatics, Madison, WI, 3University of Wisconsin - Madison, Madison, WI. 505 Most Nocturnal Asthma Symptoms Occur Outside of Exacerbations and Associate with Morbidity C. C. Horner1, D. Mauger2, R. C. Strunk1, N. J. Graber2, R. F. Lemanske, Jr3, C. A. Sorkness3, S. J. Szefler4, R. S. Zeiger5, L. M. Taussig6, L. B. Bacharier1; 1Washington University School of Medicine, Saint Louis, MO, 2Pennsylvania State University, Hershey, PA, 3University of Wisconsin, Madison, WI, 4National Jewish Health, Denver, CO, 5Univeristy of California, San Diego, CA, 6University of Denver, Denver, CO. 506 Comparison of Bronchial Hyperresponsiveness to Methacholine and Mannitol in Asthmatic Children M. ANDREGNETTE, M. FERNANDEZ-NIETO, S. SANCHEZ, M. GARCIA, E. AGUADO, M. IBAÑEZ, J. SASTRE; FUNDACION JIMENEZ DIAZ, MADRID, SPAIN. 507 Exercise Limitation Contributes to Uncontrolled Asthma in Pediatric Patients S. Thobani, E. Hu, T. Morphew, P. Huynh, M. Li, L. Scott; univeristy of southern California, Los Angeles, CA.

Primary Immunodeficiency 3602 Session Time: Sunday, March 20, 2011 2:00:00 PM - 3:15:00 PM

508 The Hyper-IgE Syndromes: Evaluation Of Over 80 Patients With Eczema And Elevated Serum Ige E. D. Renner1, L. Schimke1, J. Sawalle-Belohradsky1, B. Hagl1, K. Schwarz2, A. Langbeck1, A. Wollenberg3, J. Reichenbach4, R. Seger4, G. Notheis1, J. Roesler5, M. Borte6, T. Niehuis7, V. Wahn8, M. Hoenig9, H. Hill10, M. Albert1, T. Torgerson11, B. Belohradsky1, H. Ochs11; 1Dr. von Haunersches Kinderspital, Munich, GERMANY, 2Institute for Clinical Transfusion medicine and Immunogenetics Ulm and Institute for Transfusion Medicine, University Ulm, Ulm, GERMANY, 3University Dermatology Hospital, LudwigMaximilians University, Munich, GERMANY, 4University Children’s Hospital, Zurich, SWITZERLAND, 5University Children’s Hospital, Dresden, GERMANY, 6St. Georgs Klinikum, Leipzig, GERMANY, 7Children’s Hospital, Helios Kliniken, Krefeld, GERMANY, 8University Children’s Hospital, Charité, Berlin, GERMANY, 9University Children’s Hospital, Ulm, GERMANY, 10University of Utah, Salt Lake City, UT, 11Seattle Children’s and University of Washington, Seattle, WA. 509 Autoimmunity in a Cohort of 106 partial DiGeorge Syndrome Pediatric Patients B. Tison, C. M. Davis, S. L. Abramson, I. Hanson, S. Nicolas, M. E. Paul, F. Seeborg, W. T. Shearer, M. D. Perez, L. M. Noroski, J. Chinen, J. Chinen; Texas Childrens Hospital, Houston, TX. 510 Statistical Analysis of Correlates of Pneumococcal Antibody Level and Avidity in Patients with Recurrent Infections A. J. Fried1, M. L. Altrich2, J. F. Halsey2, F. A. Bonilla1; 1 Children’s Hospital Boston, Boston, MA, 2 Viracor-IBT Laboratories, Lenexa, KS. 511 T-B-NK+ Severe Combined Immunodeficiency (SCID) Identified by Statewide Newborn Screening A. Thomas1, M. W. Baker1, S. M. Yannone2, M. J. Cowan2, J. M. Puck2, R. A. Gatti3, A. R. Byrom1, J. W. Verbsky4, J. M. Routes4, K. B. De Santes1, J. E. Gern1, C. M. Seroogy1;

SUNDAY

495

1The Asthma Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, 2The Children’s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA. Mast Cell Restricted, Tetramer-forming Tryptases Hinder Thrombin-Induced Coagulation of Plasma by Proteolytically Destroying Fibrinogen A. Prieto-García1,2, M. Castells1, S. Wang1, R. L. Stevens1; 1Brigham and Women Hospital, Harvard Medical School, Boston, MA, 2Hospital Gregorio Marañón, Madrid, SPAIN. Strain-dependent Influences On C-kit Function Alter The Mast Cell Phenotype Of Hyperresponsive A/J Mice H. J. Chong1, E. Cozzi2, A. Lundquist1, J. Boyce1, D. Beier2; 1Brigham and Women’s Hospital, Boston, MA, 2Harvard Medical School, Boston, MA. Inhibitors of Dipeptidyl Peptidase I (DPPI) as Mast Cell Stabilising Agents: The Contribution of DPPI in Mast Cell Activation G. El-Feki1, X. Zhou1, L. C. Lau1, J. Pedersen2, A. F. Walls1; 1University of Southampton, Southampton, UNITED KINGDOM, 2Unizyme Laboratories A/S, Hørsholm, DENMARK. IL-10 Induces Mast Cell Expression of Glycoprotein 130 and Permits IL-6 trans-signaling N. Poliak, D. Traum, D. F. LaRosa; University of Pennsylvania School of Medicine, Philadelphia, PA. Lipid Mediators in Cutaneous and Systemic Mastocytosis and the Impact of 5-LO Inhibition T. Rodriguez, M. Pfeffer, B. D. Levy, M. Castells; Brigham and Women’s hospital, Boston, MA. Ultrastructural Differences in Cutaneous Mast Cells from Patients with Hermansky-Pudlak Syndrome A. S. Kirshenbaum1, E. R. Fischer1, K. O’Brien2, W. A. Gahl2, D. D. Metcalfe1; 1NIAID, NIH, Bethesda, MD, 2NHGRI, NIH, Bethesda, MD. Whole Bood Serotonin Levels in Cutaneous Mastocytosis, Systemic Mastocytosis and Mast Cell Activation Syndrome J. Butterfield, C. Weiler; Mayo Clinic, Rochester, MN. Cultured Human Mast Cells are heterogeneous for expression of the High Affinity IgE Receptor FcRI H. Hoffmann1, P. Munk Frandsen1, L. Harder Christensen2, R. Dahl1, P. Schiøtz1; 1 Aarhus University, Aarhus, DENMARK, 2 ALK-Abello, Hørsholm, DENMARK.

AB298 Abstracts

1University

of Wisconsin, Madison, WI, 2University of CaliforniaSan Francisco, San Francisco, CA, 3University of California- Los Angeles, Los Angeles, CA, 4Medical College of Wisconsin, Milwaukee, WI. 512 CD21-/low B Cells Are Increased in Both Common Variable Immune Deficiency (CVID) and Specific Antibody Deficiency(SAD) A. Elizalde, S. Hudey, M. Dorsey, E. Perez, J. Sleasman, P. Sriaroon; University of South Florida/All Children’s Hospital, St. Petersburg, FL.

Getting at Asthma Severity: Environmental and Genetic Exposures

SUNDAY

3603 Session Time: Sunday, March 20, 2011 2:00:00 PM - 3:15:00 PM

513 Smoking, Environmental Tobacco Smoke, and Aspirin Exacerbated Respiratory Disease J. E. Chang1, D. Ding2, A. A. White1, J. Martin3, D. D. Stevenson1; 1Scripps Clinic, San Diego, CA, 2UCSD, San Diego, CA, 3Arquitecto Marcide Hospital, La Coruna, SPAIN. 514 Are Severe Lung Infections in the First 2 Years of Life Related to Lung Function at 18 Years C. Nicholas1, G. Wegienka1, S. Havstad1, E. Zoratti1, D. Ownby2, C. C. Johnson1; 1Henry Ford Health System, Detroit, MI, 2Medical College of Georgia, Augusta, GA. 515 The Combination of Mouse and Cockroach Exposure May Have Greater Effect on Lung Function and Health Care Utilization than either Cockroach or Mouse Exposure Alone S. K. Ahluwalia1, J. N. Saams1, P. N. Breysse2, G. B. Diette1, E. C. Matsui1; 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD. 516 Cat Ownership and Fel d 1 in Bed Dust were Associated with Increased Sensitization to Cat, but Not Asthma Symptoms Among Middle-income Children in New York City O. E. Olmedo1, I. F. Goldstein2, L. Acosta1, A. Divjan1, A. G. Rundle2, G. L. Chew1, R. B. Mellins3, L. Hoepner1,4, H. Andrews4,5, S. Lopez-Pintado5, J. W. Quinn6, F. P. Perera1, R. L. Miller1,7, J. S. Jacobson2, M. S. Perzanowski1; 1 Columbia University, Mailman School of Public Health, Department of Environmental Health Sciences, New York, NY, 2 Columbia University, Mailman School of Public Health, Department of Epidemiology, New York, NY, 3Columbia University, College of Physicians and Surgeons, Department of Pediatrics, New York, NY, 4Columbia University, Mailman School of Public Health, Data Coordinating Center, New York, NY, 5Columbia University, Mailman School of Public Health, Department of Biostatistics, New York, NY, 6 Columbia University, Institute for Social and Economic Research and Policy, New York, NY, 7Columbia University, Department of Medicine, Division of Pulmonary, Allergy, Critical Care Medicine, New York, NY. 517 Toll-like receptor (TLR2) Regulates Organic Dust-Induced Airway Inflammation J. A. Poole, T. A. Wyatt, T. Kielian, P. Oldenburg, A. Gleason, A. Bauer, W. West, J. Sisson, D. J. Romberger; UNMC, Omaha, NE.

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

Allergic Skin Disorders 3604 Session Time: Sunday, March 20, 2011 2:00:00 PM - 3:15:00 PM

518 Reductions in an Epidermal Tight Junction Protein Enhance Atopic Dermatitis Subjects’ Susceptibility to HSV Infections A. De Benedetto1, N. M. Rafaels2, M. Dubois3, M. Bolognino1, D. Y. Leung4, K. C. Barnes2, M. K. Slifka3, L. A. Beck1; 1Department of Dermatology, University of Rochester Medical Center, Rochester, NY, 2Lowe Family Genomics Core, Johns Hopkins University School of Medicine, Baltimore, MD, 3Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, 4Department of Pediatrics, National Jewish Health, Denver, CO. 519 Interferon-gamma (IFNG) and IFNGR1 Gene Variants are Associated with Atopic Dermatitis Complicated by Eczema Herpeticum (ADEH) and IFN Production P. Gao1, D. Y. Leung2, N. M. Rafaels1, M. Boguniewicz2, B. Armstrong3, D. J. Zaccaro3, L. C. Schneider4, T. R. Hata5, J. M. Hanifin6, L. A. Beck7, A. Weinberg8, K. C. Barnes1; 1JHAAC, Baltimore, MD, 2National Jewish Health, Denver, CO, 3Rho Inc, Chapel Hill, NC, 4Boston Children’s Hospital, Boston, MA, 5UCSD Medical Center, San Duego, CA, 6University of Oregon Health Sciences Center, Portland, OR, 7University of Rochester Medical Center, Rochester, NY, 8University of Colorado Denver, Aurora, CO. 520 Reduced Epidermal Expression of Toll-like receptor 2 in Atopic Dermatitis - Another Explanation for TJ Dysfunction? I. Kuo1,2, A. Debenedetto1, T. Yoshida1, L. A. Beck1; 1Department of Dermatology University of Rochester Medical Center, Rochester, NY, 2Department of Pathology and Laboratory Medicine University of Rochester Medical Center, Rochester, NY. 521 Variations In The FLG2 Gene Are Associated With Eczema Herpeticum In Populations Of European And African Descent N. M. Rafaels1, D. Y. Leung2, L. Beck3, P. S. Gao1, M. Campbell1, M. Boguniewicz3, T. Hata4, L. Schneider5, J. Hanifin6, R. Gallo4, L. Gao1, T. H. Beaty7, K. C. Barnes1; 1Johns Hopkins Asthma & Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Pediatrics, National Jewish Health, Denver, CO, 3Department of Dermatology, University of Rochester Medical Center, Rochester, NY, 4Division of Dermatology, University of California, San Diego, CA, 5Division of Immunology, Children’s Hospital Boston, Boston, MA, 6Department of Dermatology, Oregon Health & Science University, Portland, OR, 7Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD. 522 Clinical Implication of Serum CXCL13 in Children with Atopic Dermatitis H. Park, Y. Park, J. Hong, K. Kim, M. Sohn, K. Kim; Severance hospital, Seoul, KOREA, REPUBLIC OF.

Health Behavior and Education, Epidemiology and Informatics 3605 Session Time: Sunday, March 20, 2011 2:00:00 PM - 3:15:00 PM

523 Use of Electronic Medical Record for Allergen Immunotherapy to enhance patient safety P. Buddiga1, M. N. Baz1, M. H. Bashir2; 1Baz Allergy Asthma and Sinus Center, Fresno, CA, 2University of California San Francisco Fresno Education Program, Fresno, CA.

524 Asthma and Anaphylaxis Mortality Trends in Chile Between 1991 and 2008 A. Borzutzky, R. Hoyos, J. Cerda; Pontificia Universidad Catolica de Chile, Santiago, CHILE. 525 Birth Order Effect on the Prevalence of Childhood Allergy: Comparisons among Different Allergic Diseases T. Kusunoki1,2, K. Mukaida1,3, T. Morimoto4, M. Sakuma4, N. Mito1, T. Yasumi2, R. Nishikomori2, T. Fujii1, T. Heike2; 1Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Shiga, JAPAN, 2Department of Pediatrics, Graduate School of Medicine, Kyoto Univeristy, Kyoto, JAPAN, 3Kumiko Allergy Clinic, Kyoto, JAPAN, 4Center for Medical Education, Graduate School of Medicine, Kyoto University, Kyoto, JAPAN. 526 Exercise-induced Bronchospasm (EIB) Express Seminar: Method of Education C. A. Jones; AANMA, McLean, VA. 527 The Power of Education: Food Allergy Intervention and Prevention in Houston Independent School District (HISD) S. S. Shah1, C. L. Parker2, C. M. Davis1; 1Baylor College of Medicine, Department of Pediatrics, Section of Allergy and Immunology, Houston, TX, 2Baylor College of Medicine, Department of Pediatrics, Section of Epidemiology, Houston, TX.

Rhinosinusitis 3606 Session Time: Sunday, March 20, 2011 2:00:00 PM - 3:15:00 PM

528 A Replication Study Validates The Association Of 14 Snps In 11 Genes With Chronic Rhinosinusitis With Nasal Polyposis L. Mfuna Endam1, A. Filali-Mouhim1, P. Boisvert2, L. Boulet3, Y. Bossé3,4, M. Desrosiers5,6; 1Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, QC, CANADA, 2Department of Otolaryngology, Saint- François d’Assise Hospital, Quebec, QC, CANADA, 3Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, QC, CANADA, 4Laval University Hospital Research Center (CRCHUL), Quebec, QC, CANADA, 5Departement of Otolaryngology-Head and Neck Surgery, CHUM, Montreal, QC, CANADA, 6Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montréal, QC, CANADA. 529 Common Polymorphisms in the IL1RL1 Gene in CRS Patients are Associated with Reduced Gene Expression and Reduced Th2-Cell Function M. Chater1, L. Mfuna2, C. Divoy2, S. Al-Mot2,3, A. FilaliMouhim2, S. Rousseau4, M. Desrosiers1,5; 1 McGill University, Montreal, QC, CANADA, 2 Centre de Recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montreal, QC, CANADA, 3McGill University, Montréal, QC, CANADA, 4Meakins Christie Laboratory, McGill University, Montreal, QC, CANADA, 5Centre de Recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montréal, QC, CANADA. 530 TSLP Signaling and TH2-type Inflammation is Enhanced in Eosinophilic but not Noneosinophilic Nasal Polyps P. Cao1, B. Wang2, Y. Zhang1, X. You1, Q. Gao1, Y. Cui1, Z. Liu1; 1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, CHINA, 2Wuhan Pu-Ai Hospital, Wuhan, CHINA. 531 Elevated Expression of CC Chemokine Ligand 18 in Chronic Rhinosinusitis

A. Kato1, S. Peterson1, J. A. Poposki1, D. R. Nagarkar1, R. T. Chustz1, A. T. Peters1, L. A. Suh1, R. Carter1, J. Norton1, K. E. Harris1, L. C. Grammer1, B. Tan2, R. K. Chandra2, D. B. Conley2, R. C. Kern2, R. P. Schleimer1; 1Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL. 532 Reduced Expression of Antimicrobial Palate, Lung and Nasal Epithelial Clone (PLUNC) protein in Polyps from Patients with Chronic Rhinosinusitis is Due to Decreased Number of Glands S. Seshadri1, M. Rosati1, D. Lin1, R. Carter1, J. Norton1, A. Kato1, L. Suh1, A. Peters1, R. Chandra2, K. Harris1, H. Chu3, D. Conley2, B. Tan2, L. Grammer1, R. Kern2, R. Schleimer1; 1 Department of Medicine, Allergy-Immunology Division, Northwestern University, Chicago, IL, 2 Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Department of Medicine, National Jewish Health, Denver, CO.

Regulation in Atopic Disease 3607 Session Time: Sunday, March 20, 2011 2:00:00 PM - 3:15:00 PM

533 The P2Y6 Receptor for Uridine Diphosphate Inhibits T Cell Activation and Dampens Allergic Pulmonary Inflammation G. Giannattasio1,2, J. R. Boyce1, B. H. Sell1, W. Xing1,2, B. Balestrieri1,2, J. A. Boyce1,2; 1Division of Rheumatology, Immunology & Allergy, Brigham and Women’s Hospital, Boston, MA, 2Department of Medicine, Harvard Medical School, Boston, MA. 534 IL-4 Plays a Pivotal Role in Regulating the Development of Th2 and Th17 Responses in the Airways T. Kobayashi, K. Iijima, J. L. Checkel, H. Kita; Mayo Clinic Rochester, Rochester, MN. 535 Myeloid-derived Regulatory Cells in the Airways of Asthmatic and COPD Patients J. S. Deshane1, M. Zeng1, J. W. Zmijewski1, M. Spell1, J. T. Anderson1, D. Redden1, E. Abraham1, A. Gaggar1,2, M. Dransfield1,2, D. D. Chaplin1; 1University of Alabama at Birmingham, Birmingham, AL, 2V A Medical Center, Birmingham, AL. 536 NADPH Oxidase In Ragweed Pollen Promotes Th2 Differentiation Of Naïve T-cells And Induces IL-33 Secretion From BMDCs Via TLR4 And MYD88 Dependent Pathways A. Kalita1, H. Qi1, H. Murai1, A. Kurosky1, I. Boldogh1, T. Hazra,1, D. Corry2, S. Sur1; 1UTMB, Texas, TX, 2Baylor College of Medicine, Texas, TX. 537 Experimental Food Allergy with defective formation of induced Regulatory T (iTreg) Cells: Phenotype Rescue With AllergenSpecific Treg cell therapy M. Noval-Rivas, Y. Zhang, M. Garcia-Lloret, T. Chatila; UCLA, Los Angeles, CA.

Anaphylaxis and Drug Allergy 3608 Session Time: Sunday, March 20, 2011 2:00:00 PM - 3:15:00 PM

538 Persistent Protection by FAHF-2 in Food Allergy: Effects on Mast cells/Basophils, and Identification of Active Compounds Y. SONG1, C. Qu1, K. D. Srivastava1, N. Yang1, W. Zhao2, X. Li1; 1Mount Sinai School of Medicine, New York, NY, 2Virginia Commonwealth University, Richmond, VA.

SUNDAY

Abstracts  AB299

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB300 Abstracts

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

SUNDAY

539 Mast Cell Chymase: A Useful Serum Marker in Anaphylaxis X. Zhou1, H. S. Whitworth1, M. E-Khedr1, T. A. Brown1, R. Goswami2, E. Eren2, J. A. Lucas1, M. D. S. Erlewyn-Lajeunesse1, C. W. Summers3, R. S. H. Pumphrey3, G. Wild4, J. Pedersen5, A. F. Walls1; 1University of Southampton, Southampton, UNITED KINGDOM, 2Southampton University Hospital Trust, Southampton, UNITED KINGDOM, 3University of Manchester/Manchester Royal Infirmary, Manchester, UNITED KINGDOM, 4Northern General Hospital, Sheffield, UNITED KINGDOM, 5Unizyme Laboratories A/S, Hørsholm, DENMARK. 540 Mast Cell Carboxypeptidase as a Confirmatory and Predictive Marker in Allergic Reactions to Drugs T. A. Brown1, H. S. Whitworth1, X. Y. Zhou1, L. Lau1, E. Eren2, A. F. Walls1; 1University of Southampton, Southampton, UNITED KINGDOM, 2Southampton University Hospitals NHS Trust, Southampton, UNITED KINGDOM. 541 Adverse Reactions Associated With Therapeutic Cephalosporin And Sulfonamide Antibiotic Use After Penicillin Skin Testing E. M. Macy1, N. J. Ho2; 1SCPMG-Kaiser Permanente San Diego, San Diego, CA, 2Kaiser Permanente Southern California, Department of Research and Evaluation, Pasadena, CA. 542 Repeat Skin Testing Improves Risk Stratification For Platinumbased Chemotherapy Desensitizations S. Patil, M. Ling, M. T. Wilson, A. Long, P. Hesterberg, J. T. Wong, A. Banerji; Massachusetts General Hospital, Boston, MA.

Featured Poster Session

Topics in Primary Immunodeficiency 3802 Session Time: Sunday, March 20, 2011 5:30:00 PM - 6:30:00 PM

548 Characterization Of Dock8 Expression In Danio Rerio W. Chan, S. McGhee; University of California, Los Angeles, Los Angeles, CA. 549 Are Severe Combined Immune Deficiency (SCID) Cases Missed at a Children’s Hospital? P. Poowuttikul1, N. Mireku1, A. Kujawska1, D. GonzalezEspinosa2, P. Maitland-McKinley2, W. Young3, E. Secord1, J. Puck2; 1Children’s Hospital of Michigan, Wayne State University, Detroit, MI, 2University of California, San Francisco, San Francisco, CA, 3Newborn Screening Program, Department of Health, State of Michigan, Lansing, MI. 550 Cohort Characteristics and Mortality Analysis: 473 Patients with CVID Followed at Mt. Sinai Medical Center. E. S. Resnick, E. L. Moshier, J. H. Godbold, C. CunninghamRundles; Mt. Sinai Medical Center, New York, NY. 551 T-cell Receptor Excision Circles of Newborns Are Associated with Gestational Age: Data from Wisconsin Newborn Screening for Severe Combined Immunodeficiency M. Baker1, A. Atkins1, W. Grossman2, C. Seroogy1, M. Lindstrom1, C. Brokopp1, J. Routes2; 1University of Wisconsin School of Medicine and Public Health, Madison, WI, 2Medical College of Wisconsin, Milwaukee, WI. 552 Abnormalities In B Cell Homeostasis And Tolerance In Common Variable Immunodeficiency (CVID) G. Dhillon, C. Z. Marcus, J. Hossler, A. Palanichamy, J. H. Anolik; University of Rochester, Rochester, NY.

Asthma Therapy

Viral and Chemical Triggers of Atopy and Asthma in Children

3801 Session Time: Sunday, March 20, 2011 5:30:00 PM - 6:30:00 PM

3803 Session Time: Sunday, March 20, 2011 5:30:00 PM - 6:30:00 PM

543 Reduced Response to Corticosteroids in PBMC from Patients with Steroid Resistant Asthma L. P. Jackson, D. Y. Leung, M. C. Gleason, E. Goleva; National Jewish Health, Denver, CO. 544 Calcitriol increases the Expression of Importin7 (IPO7) and Importin13 (IPO13) in Human Bronchial Smooth Muscle Cells T. Agrawal, D. K. Agrawal; Center for Clinical and Translational Sciences, Creighton University School of Medicine, Omaha, NE. 545 In Human, Anti-TNF Inhibits The Airways Neutrophilic Inflammation Induced By Inhaled Endotoxin O. Michel1, P. Huy Duc Dinh1, F. Corazza1, K. Mestdagh1, Z. Kassengera1, V. Doyen1, P. Wiesel2; 1Université Libre de Bruxelles - ULB, Brussels, BELGIUM, 2Funxional Therapeutics Ltd, Cambridge, UNITED KINGDOM. 546 Multiple Oral Corticosteroid Courses for Wheezing Illnesses in Infancy are Associated with Reduced Subsequent Lung Function D. J. Jackson, S. R. Durrani, M. D. Evans, E. L. Anderson, C. J. Tisler, R. E. Gangnon, J. E. Gern, R. F. Lemanske, Jr.; University of Wisconsin, Madison, WI. 547 Asthmatics with Insufficient Serum Vitamin D Levels have Reduced Response to Corticosteroids In Vitro E. Goleva, L. P. Jackson, B. N. Richers, D. A. Searing, D. Y. Leung; National Jewish Health, Denver, CO.

553 Bisphenol-A Exposure and Asthma In An Inner-City Birth Cohort K. M. Donohue1, R. L. Miller2, M. S. Perzanowski2, A. C. Just2, L. A. Hoepner2, S. Arunajadai3, F. P. Perera2, R. M. Whyatt2; 1 Columbia Presbyterian Medical Center, New York, NY, 2Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 3Department of Biostatistics, Mailman School of Public Health, New York, NY. 554 Circulating Eosinophil/Basophil (Eo/B) Progenitors at One Year of Age Positively Correlate with Atopic Eczema and Indoor Chemical Exposure in the LINA Study K. Weisse1,2, I. Lehmann1, G. Herberth1, T. Kohajda3, S. Röder4, M. Borte5, D. Heroux2, J. Denburg2; 1Helmholtz Centre for Environmental Research - UFZ, Department Environmental Immunology, Leipzig, GERMANY, 2McMaster University, Division of Clinical Immunology and Allergy, Hamilton, ON, CANADA, 3Helmholtz Centre for Environmental Research - UFZ, Department Metabolomics, Leipzig, GERMANY, 4Helmholtz Centre for Environmental Research - UFZ, Core Facility Studies, Leipzig, GERMANY, 5Children’s Hospital, Municipal Hospital “St. Georg”, Leipzig, GERMANY. 555 Increased H1N1 Infection Rate in Asthmatic Children K. M. Kloepfer, J. P. Olenec, W. Lee, T. E. Pappas, G. Liu, R. F. Vrtis, M. D. Evans, R. E. Gangnon, J. E. Gern; University of Wisconsin, Madison, WI.

556 The Role of Notch-Notch Ligand Signaling in Primary and Secondary Respiratory Syncytial Virus (RSV) Infection J. Han1, M. Okamoto1, K. Takeda1, K. Yasutomo2, E. W. Gelfand1; 1National Jewish Health, Denver, CO, 2The University of Tokushima Graduate School, Tokushima, JAPAN. 557 Potential Metabolic Basis For The Perinatal Effects Of Bisphenol A (BPA) Exposure On The Development Of Asthma Y. Nakajima, R. M. Goldblum, T. Midoro-Horiuti; The University of Texas Medical Branch, Galveston, TX.

FADDA Featured Poster Session 3804 Session Time: Sunday, March 20, 2011 5:30:00 PM - 6:30:00 PM

558 Effect Of Oral Anti-histamines On The Thresholds Of Hen’S Egg- And Cow’S Milk-induced Anaphylactic Patients T. Utsunomiya, T. Imai, N. Yanagida, S. Sato, T. Komata, M. Tomikawa, A. Shukuya, M. Ebisawa; Sagamihara National Hospital, Sagamihara, JAPAN. 559 IgE Epitope Mapping of Ara h 2 and Ara h 6 by Microarray Immunoassay K. Otsu1,2, Y. Zhang1, S. Dreskin1; 1University of Colorado Denver, Aurora, CO, 2National Jewish Health, Denver, CO. 560 Specificity Protein 1 is Pivotal in the Skin’s Anti-viral Response L. Bin1, B. E. Kim1, C. F. Hall1, D. J. Zaccaro2, D. Y. Leung1; 1National Jewish Health, Denver, CO, 2Rho Inc, Chapel Hill, NC. 561 TNF-alpha Down-Regulates Filaggrin and Loricrin Through c-Jun N-Terminal Kinase: Role for TNF Antagonists to Improve Skin Barrier B. E. Kim1, M. D. Howell1, E. Guttman2, P. Gilleaudeau2, I. Cardinale2, M. Boguniewicz1, J. G. Krueger2, D. Y. Leung1; 1National Jewish Health, Denver, CO, 2The Rockefeller University, New York, NY. 562 Total Serum IgE Affects Predictive Value of Food-specific IgE A. S. Haque1,2, E. Yousef1,2, S. McGeady1,2, J. Hossain1; 1Alfred I. duPont Hospital for Children, Wilmington, DE, 2Thomas Jefferson University, Philadelphia, PA.

HEDQ Featured Poster Session 3805 Session Time: Sunday, March 20, 2011 5:30:00 PM - 6:30:00 PM

563 Is Quality of Life Affected in Adults and Children With Asthma Who Experience Exercise-Related Respiratory Symptoms? Results From the EIB Landmark Survey T. Craig1, G. Colice2, J. Parsons3, M. Hayden4, S. Stoloff5, N. Eid6, N. Ostrom7; 1Pennsylvania State University, Hershey, PA, 2Washington Hospital Center, Silver Spring, MD, 3Ohio State University Asthma Center, Columbus, OH, 4University of Virginia, Charlottesville, VA, 5University of Nevada School of Medicine, Reno, NV, 6University of Louisville School of Medicine, Louisville, KY, 7Allergy & Asthma Medical Group and Research Center, San Diego, CA. 564 The Relationship Between Self-reported Non-adherence (NA) To Anti-inflammatory Therapy and Asthma Management Behaviors/Attitudes Related to NA in Adult Patients A. G. Weinstein1, J. Laurenceau2, J. Vok3; 1Jefferson Medical College, Newark, DE, 2University of Delaware, Newark, DE, 3Asthma and Allergy Foundation of America, Landover, MD.

Abstracts  AB301

565 Using Focus Groups to Inform the Design of a Behavioral Controlled Trial to Improve Adherence to Asthma Controller Medications among Low-Income African American Adolescents S. Shah1, S. Resnick2, M. Damitz3, C. Kohrman4, L. Powell1, G. Mosnaim1; 1Rush University Medical Center, Chicago, IL, 2Cornell University, Ithaca, NY, 3Respiratory Health Association of Metropolitan Chicago, Chicago, IL, 4Community Research and Training Consultant, Chicago, IL. 566 Further Validation and Definition of the Psychometric Properties of the Asthma Impact Survey M. Schatz, R. Zeiger, S. Yang, W. Chen, M. Kosinski; Kaiser Permanente, San Diego, CA. 567 Asthma in Cincinnati’s Elderly Study: Significant Impact of Asthma on Psychosocial Function A. M. Smith1,2, E. T. Stanforth1, M. Villareal1, D. J. Swikert3, D. I. Bernstein1; 1University of Cincinnati Medical Center, Cincinnati, OH, 2Cincinnati VA Medical Center, Cincinnati, OH, 3St. Elizabeth Medical Center, Edgewood, KY.

The Best of IRSOC 3806 Session Time: Sunday, March 20, 2011 5:30:00 PM - 6:30:00 PM

568 Allergomic Characterization Of Bodies And Feces From D. Pteronyssinus And D. Farinae: Implications For House Dust Mite Allergen-specific Immunotherapy T. Batard; Stallergenes SA, Antony, FRANCE. 569 Allergen Immunotherapy Significantly Reduces Healthcare Costs among U.S. Adults with Allergic Rhinitis: A Retrospective Matched Cohort Study Jointly Funded by the AAAAI and ACAAI Z. Wang1, C. S. Hankin1, L. Cox2, A. Bronstone1; 1 BioMedEcon, LLC, Moss Beach, CA, 2 Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL. 570 Exposure To Consistent And Controlled Levels Of Aerosolized Dust Mite Allergen Evokes Ocular Symptoms In Dust Mite Allergic Patients J. S. Lee, D. Wilson, N. Camuso, D. Patel, A. Salapatek; Cetero Research, Mississauga, ON, CANADA. 571 Evidence For Species-related Differences Between Grass Pollen Allergens: Implications For Immunotherapy P. Moingeon; Stallergenes SA, Antony, FRANCE. 572 Sustained Efficacy and Safety Of a Pre-coseasonal 300IR 5-grass Pollen SLIT Tablet Over 3 Pollen Seasons In Adult SAR A. Didier1, M. Worm2, F. Horak3, M. Mélac4, O. De Beaumont4, M. Le Gall4, A. Montagut4, S. Galvain4, H. Malling5; 1Service de Pneumologie-Allergologie Hôpital Larrey CHU de Toulouse, Toulouse, FRANCE, 2Allergie-Centrum-Charité, Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Berlin, Berlin, GERMANY, 3Allergy Centre Vienna West, Vienna, AUSTRIA, 4Stallergenes SA, Antony, FRANCE, 5 National University Hospital, Copenhagen, DENMARK.

SUNDAY

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB302 Abstracts

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

The Many Faces of IgE 3807 Session Time: Sunday, March 20, 2011 5:30:00 PM - 6:30:00 PM

573 Relationship between Serum 25-Hydroxyvitamin D and IgE: National Health and Nutrition Examination Survey 2-Year Results Z. D. Jacobs, H. Dai, M. Feldt, C. Dinakar; Children’s Mercy Hospital and Clinics, Kansas City, MO. 574 IgE Is Not Needed For Induction Of FcRI On Murine Lung Conventional Dendritic Cells G. Graves, E. Shakir, D. Riley, M. H. Grayson; Medical College of Wisconsin, Milwaukee, WI. 575 Murine B Cells Capture Serum Ige And Directly Regulate Serum Ige Levels L. E. Cheng, R. M. Locksley; UCSF Medical Center, San Francisco, CA. 576 The Role of Mannose Receptor in IgE Production in an in vivo Model of Cat Allergy A. M. Ghaemmaghami, M. Emara, L. Martinez-Pomares, F. Shakib; The University of Nottingham, Nottingham, UNITED KINGDOM. 577 Cord Blood 25-Hydroxyvitamin D Levels Have a Non-Linear Association with Aeroallergen Sensitization Through Age 5 Years In Tucson, Arizona J. Rothers1, A. L. Wright1, M. Halonen1, C. A. Camargo2; 1University of Arizona, Tucson, AZ, 2Harvard Medical School, Boston, MA.

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Allied Health Featured Poster Session

MONDAY

3811 Session Time: Sunday, March 20, 2011 5:30:00 PM - 6:30:00 PM

578 Parents of Urban Children with Asthma Overestimate Their Children’s Asthma Control J. N. Saams1, J. Curtin-Brosnan1, G. B. Diette1, P. N. Breysse2, E. C. Matsui1; 1John Hopkins University, Baltimore, MD, 2John Hopkins School of Public Health, Baltimore, MD.

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Poster Session Asthma Epidemiology II

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4201 Session Time: Monday, March 21, 2011 9:45:00 AM - 10:45:00 AM

579 Relationship Between Body Mass Index (BMI) and Baseline Characteristics in Non-Black and Black Populations With Moderate to Severe Persistent Asthma S. L. Spector1, T. Uryniak2, U. J. Martin2; 1California Allergy & Asthma Medical Group, Los Angeles, CA, 2AstraZeneca LP, Wilmington, DE. 580 The Association Between Asthma Symptoms And Obesity In Adolescents K. Yoshida1, I. Masuko1,2, T. Akada3, T. Itazawa4, Y. Adachi4, A. Akasawa2, Y. Ohya1; 1National Center for Child Health and Development, Tokyo, JAPAN, 2Tokyo Metropolitan Children’s Medical Center, Tokyo,

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JAPAN, 3Seishin high school & junior high school, Ibaraki, JAPAN, 4University of Toyama, Toyama, JAPAN. Assessment of The Association of Asthma Status with Selective IgA Deficiency and Common Variable Immunodeficiency: A Population-Based Case-Control Study Y. Juhn1, H. Yun1,2, S. Urm1,3, Y. Fenta1, K. Yoo1,4, R. Abraham5, J. Hagan6; 1Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, 2Department of Medicine, Harbor Hospital, Baltimore, MD, 3Department of Preventive Medicine, Medical College, Inje University, Busan, KOREA, REPUBLIC OF, 4Department of Internal Medicine, School of Medicine, Konkuk University, Seoul, KOREA, REPUBLIC OF, 5Department of Laboratory Medicine, Mayo Clinic, Rochester, MN, 6Department of Medicine, Mayo Clinic, Rochester, MN. Effects of Asthma Severity and Medication Use on Prematurity and Intrauterine Growth: A Meta Analysis from Published Data J. A. Namazy1, V. E. Murphy2, H. Powell3, P. G. Gibson4, C. Chambers5, M. Schatz6; 1Scripps Clinic, San Diego, CA, 2Center for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, AUSTRALIA, 3John Hunter Hospital, Newcastle, AUSTRALIA, 4Center for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute,John Hunter Hospital, Newcastle, AUSTRALIA, 5University of California at San Diego, San Diego, CA, 6Kaiser Permanente Medical Center, San Diego, CA. Epidemiology of Asthma and Other Respiratory Admissions in a Referral Hospital in Gaborone, Botswana S. Kung1,2, L. Mazhani1, A. P. Steenhoff2,3; 1University of Botswana, Gaborone, BOTSWANA, 2Children’s Hospital of Philadelphia, Philadelphia, PA, 3Botswana-UPENN Partnership, Gaborone, BOTSWANA. Gap between Guideline Recommend Treatment and Reality in Japanese Child Asthma A. Akasawa1, K. Yoshida2, M. Furukawa1, Y. Adachi3, Y. Ohya2, H. Odajima4; 1Tokyo Metropolitan Children’s Medical Center, Tokyo, JAPAN, 2National Center for Child Health and Development, Tokyo, JAPAN, 3Toyama University, Toyama, JAPAN, 4NHO Fukuoka Hospital, Fukuoka, JAPAN. Prevalence Of Asthma Symptoms In Preschool Children(3-5 Years Old) In Hat Yai Municipality P. Kulalert1, P. Sangsupawanich2; 1Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, THAILAND, 2Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hatyai, THAILAND. The Influence of Environment on Respiratory Allergy. A Survey on Immigrants to Italy G. Passalacqua1, C. Lombardi2, G. Canonica1; 1Allergy and Respiratory Diseases, DIMI, University of Genoa, Genova, ITALY, 2Allergy Unit, Department of Internal Medicine, Sant’Orsola Hospital, Brescia, Brescia, ITALY. Dental Caries In The Primary Dentition Of Mexican Children Relationship with asthma F. Vazquez-Nava1, E. M. Vázquez-Rodríguez2, M. d. BarrientosGomez3, J. A. Cordova-Fernandez4, D. Lin-Ochoa3, F. J. BeltránGuzman3, C. F. Vázquez-Rodríguez3, G. M. Martínez-Perales3, A. H. Saldívar-González3; 1Social Securirty Mexican Institute. Tampico Faculty of Medicine. Universidad Autonoma de Tamaulipas., Ciudad Madero, MEXICO, 2 Tampico Faculty of Medicine. Universidad Autonoma de Tamaulipas., Ciudad Madero, MEXICO, 3Tampico Faculty of

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Medicine. Universidad Autonoma de Tamaulipas., Tampico, MEXICO, 4Social Securirty Mexican Institute. Tampico Faculty of Medicine. Universidad Autonoma de Tamaulipas., Tampico, MEXICO. Sensitization to Aeroallergens in Asthmatic Children Living in Rural or Urban Area in Montes Claros, Minas Gerais, Brazil M. A. Quadros-Coelho1, C. P. Barbosa1, M. F. Silveira1, D. Solé2; 1UNIMONTES, Montes Claros, BRAZIL, 2UNIFESP-EPM, São Paulo, BRAZIL. Gene-gene Interactions for Asthma and Bronchodilator Responsiveness in Chinese Adults T. F. Leung1, F. W. S. Ko2, H. Y. Sy1, H. Y. Chu2, I. H. S. Chan3, G. W. K. Wong1, D. S. C. Hui2; 1Department of Pediatrics, The Chinese University of Hong Kong, Hong Kong, HONG KONG, 2Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, HONG KONG, 3Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, HONG KONG. Correlates Of Repeated Admissions For Asthma In An Urban Tertiary Care Hospital In Saudi Arabia A. Hasan, E. Yousef; King Faisal Specialist Hospital & Research Centre, Jeddah, SAUDI ARABIA. Prevalence of Asthma and Allergic Diseases in Riverine Schoolchildren from Amazon Islands: Outeiro and Combu M. S. Freitas, J. C. Monteiro, D. Solé; Federal University of Sao Paulo, Sao Paulo, BRAZIL. Trends in Asthma Healthcare Utilization in Southern Nevada J. S. Seggev1, S. Moonie2, C. J. Guillermo2; 1Joram S. Seggev, MD, CHTD., Las Vegas, NV, 2University of Nevada, Las Vegas, Las Vegas, NV. Risk Factors For Adult-onset Asthma. FENASMA study R. Pelta Fernández1, A. Alvarez-Perea1, J. De Miguel Díez2; 1 Allergy Service, Hospital General Universitario Gregorio Marañón, Madrid, SPAIN, 2Neumology Service, Hospital General Universitario Gregorio Marañón, Madrid, SPAIN. The Time Trend Of The Prevalence Of Asthma Symptoms In Adolescents I. Masuko1, T. Akada2, K. Yoshida3, M. Fufukawa1, Y. Ohya3, A. Akasawa1; 1Tokyo Metropolitan Children’s Medical Center, Tokyo, JAPAN, 2Seishin high school & junior high school, Ibaraki, JAPAN, 3National Center for Child Health and Development, Tokyo, JAPAN. Mold Allergens Sensitization and Severity of Asthma A. P. Castro-Coelho, F. G. Montenegro, F. D. Gaia, C. Bisaccioni, M. V. Aun, R. C. Agondi, J. Kalil, P. Giavina-Bianchi; University of São Paulo, São Paulo, BRAZIL.

Asthma Treatment II 4202 Session Time: Monday, March 21, 2011 9:45:00 AM - 10:45:00 AM

596 Concomitant Asthma Medication Use in Patients Using Omalizumab: Results from Three Large Insurance Claims Databases M. Lafeuille1, M. S. Duh2, J. Zhang3, D. Wertz4, T. Gu4, J. Tang2, A. Swensen3, E. L. Stanley3, P. Lefebvre1; 1Groupe d’analyse, Ltée, Montreal, QC, CANADA, 2Analysis Group, Inc., Boston, MA, 3Novartis Pharmaceuticals Corporation, East Hanover, NJ, 4HealthCore, Inc., Wilmington, DE. 597 Heliox in the Treatment of Asthma and other Diagnoses: Evidence from a National Database B. D. Tano;

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University of North Dakota School of Medicine & Health Sciences, Grand Forks, ND. Onset of Action of Two ICS/LABA Combinations as Measured by Impulse Oscillometry (IOS) in Young Adults with Asthma R. Menendez1, K. Singh2, B. Diong2, M. D. Goldman3; 1Allergy and Asthma Research Center of El Paso, El Paso, TX, 2Texas Christian University, Fort Worth, TX, 3University of Texas El Paso, El Paso, TX. Role of FeNO in predicting Asthma relapse and clinical relevance in Children on Inhaled Corticosteroid A. Syed1, A. Rehman2, M. Akram3, R. Bukhari3; 1National Allergy and Asthma Centre, Karachi, PAKISTAN, 2King Fahd Specialist Hospital, Dammam, SAUDI ARABIA, 3King Fahd University Hospital, Khobar, SAUDI ARABIA. Concomitant Asthma Medication Use in Patients Treated with Omalizumab E. Chang1, M. Broder1, J. Zazzali2; 1PHAR, LLC, Beverly Hills, CA, 2Genentech, South San Francisco, CA. Retrospective Analysis of Asthmatics Treated with Epoprostanol E. I. Majeski, J. R. Sheller; Vanderbilt University, Nashville, TN. Greater Reduction in Asthma Symptom Frequency During Treatment With Mometasone Furoate/Formoterol Combination Versus Monocomponents and Placebo C. LaForce1, E. O. Meltzer2, R. A. Nathan3, S. F. Weinstein4, H. Nolte5; 1University of North Carolina School of Medicine, Chapel Hill, NC, 2Allergy and Asthma Medical Group and Research Center, San Diego, CA, 3Asthma & Allergy Associates, P.C. and Research Center, Colorado Springs, CO, 4Allergy & Asthma Specialists Medical Group & Research Center, Huntington Beach, CA, 5Merck Research Laboratories, Kenilworth, NJ. Reduction of Nocturnal Awakenings With Mometasone Furoate Administered Via Dry Powder Inhaler in Children With Persistent Asthma Previously Receiving Other Inhaled Corticosteroids W. E. Berger1, M. Noonan2, A. Teper3, J. Moreno-Cantu4, P. Stryszak3, E. O. Meltzer5; 1Allergy & Asthma Associates, Mission Viejo, CA, 2Allergy Associates Research, Portland, OR, 3Merck Research Laboratories, Kenilworth, NJ, 4Global Publications and Medical Communications, Merck & Co., Kenilworth, NJ, 5Allergy and Asthma Medical Group and Research Center, San Diego, CA. Inhaler Use and Effect on Asthma Control N. Parikh1, P. Verma2, S. Lee2, W. B. Klaustermeyer2; 1UCLA Medical Center, Los Angeles, CA, 2VA Greater Los Angeles Healthcare System/UCLA Allergy-Immunology Division, Los Angeles, CA. Impact of Inhaled Corticosteroids on Small Airway Airflow Obstruction in Asthmatic Children N. A. Sharif, E. Sarid, J. Li, J. Fagin; NorthShore-Long Island Jewish Health System, Great Neck, NY. Effects of Low Dose combination therapy, Fluticasone Propionate/Salmeterol Combination, 100/50 (FSC 100/50) on Exhaled Nitric Oxide (eNO) and Airway Hyperresponsiveness in Mild Persistent Asthma M. A. Pasha, P. J. Feustel, T. Smith, S. Patel, S. Sarathchandra, P. Malone, M. Evans, F. Jourd’heuil, D. Jourd’heuil; Albany Medical College, Albany, NY. Severe Geriatric Asthma: Efficacy of Omalizumab in a VA population P. Verma1, I. Randhawa2, W. B. Klaustermeyer1; 1VA Greater Los Angeles Healthcare System/UCLA AllergyImmunology Division, Los Angeles, CA, 2UCLA AllergyImmunology Division, Los Angeles, CA.

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Abstracts  AB303

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB304 Abstracts

608 Comparative Effectiveness Of Extrafine Hydrofluoroalkane Beclomethasone And Fluticasone In Asthma Management: A Real-world Observational Study From The United States D. B. Price1,2, P. Dorinsky3, P. Polos4, A. Burden2, J. von Ziegenweidt2, A. Chisholm2; 1University of Aberdeen, Foresterhill Health Centre, Aberdeen, UNITED KINGDOM, 2Research in Real Life Ltd, Norfolk, UNITED KINGDOM, 3Teva Pharmaceuticals, Horsham, PA, 4i3 Research, Cary, NC. 609 Response to Budesonide/Formoterol Pressurized MeteredDose Inhaler (BUD/FM pMDI) by Patient’s Sex in Non-Black and Black Populations With Asthma S. M. Meltzer1, S. L. Spector2, T. Uryniak3, U. J. Martin3; 1Allergy and Asthma Care Center of Southern California, Long Beach, CA, 2California Allergy & Asthma Medical Group, Los Angeles, CA, 3AstraZeneca LP, Wilmington, DE. 610 Alcohol-Based Mouthwashes Following Inhaled Corticosteroids: To Use or Not To Use T. M. Nsouli1,2, E. J. McSorley-Gerard2, C. D. Schluckebier2, C. Davis2, M. Fakhriyazdi2, S. T. Nsouli2; 1Georgetown University School of Medicine, Washington, DC, 2Burke and Watergate Allergy and Asthma Research Centers, Washington, DC. 611 Dose-Dependent Anti-inflammatory Effect of Inhaled Mometasone Furoate/Formoterol in Subjects With Asthma and High Baseline Exhaled Nitric Oxide and Sputum Eosinophils S. Spector1, V. Backer2, I. Pavord3, T. Shekar4, D. Gates4, H. Nolte4; 1 Allergy and Asthma Medical Group, Los Angeles, CA, 2 Copenhagen University Hospital, Bispebjerg Hospital, Copenhagen, DENMARK, 3University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester, UNITED KINGDOM, 4Merck Research Laboratories, Kenilworth, NJ.

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4203 Session Time: Monday, March 21, 2011 9:45:00 AM - 10:45:00 AM

612 Single-Species Grass Pollen Extracts and Mixtures of Extracts From Multiple Phylogenetically Related Grass Species Activate Allergic Patients’ Basophils to the Same Degree K. Lund, G. Lund, J. Holm, J. Skovsgaard; Dpt. of Experimental Immunology, ALK-Abello A/S, Hoersholm, DENMARK. 613 Jug r 1 and Jug r 2-specific CD4+ T-Cells: Epitope Mapping, Ex Vivo Characterization, and Phenotype Analysis D. Jeong1, D. Robinson2, W. Kwok3; 1Institute for Asthma and Allergy, P.C., Chevy Chase, MD, 2Virginia Mason Medical Center, Seattle, WA, 3Benaroya Research Institute, Seattle, WA. 614 Broad Aberration In The Humoral Immune Responses To An Aeroallergen R. S. Medagoda, J. Van Bavel, R. Goldblum, T. Midoro-Horiuti; University of Texas Medical Branch, Galveston, TX. 615 Nucleotide Changes in Hypervariable Regions of Genes Coding Heavy Chains of IgE in Patients with Atopic Rhinitis, Bronchial Asthma and Atopic Dermatitis L. P. Titov1, E. A. Stolyarova1, T. A. Stolyarova1, L. M. DuBuske2; 1Republican Scientific and Practical Center for Epidemiology and Microbiology, Minsk, BELARUS, 2Immunology Research Institute of New England, Gardner, MA. 616 Substance P (SP) Induces Expression of Functional Corticotropin-Releasing Hormone Receptor-1 (CRHR-1) in Human Mast Cells

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S. Asadi, B. Zhang, K. Alysandratos, A. Angelidou, M. Vasiadi, T. Theoharides; Tufts University, Boston, MA. Plasma Complement Split Products as Biomarkers of Allergic Responses to Dust Mite R. Karanicolas, D. P. Erstein, R. Joks; Center for Allergy and Asthma Research, SUNY Downstate Medical Center, Brooklyn, NY. Carbohydrate Moieties Contained in Dust Mite Allergen Promote IL-10 Production by Dendritic Cells N. Gour, K. Dienger, M. Wills-Karp; Cincinnati Children’s Hospital Medical Centre, Cincinnati, OH. Impact OF Allergen Specific Immunotherapy on Allergen Threshold for Basophil Activation and Inhibitory IgG Antibodies in Birch Pollen Allergic Patients M. Kosnik1, N. Lalek1, M. Silar1, P. Korosec1, L. M. DuBuske2; 1University Clinic of Respiratory and Allergic Diseases, Golnik, SLOVENIA, 2Immunology Research Institute of New England, Gardner, MA. Component Resolved Diagnosis Using An Immunoassay Platform For Multiplex Measurement Of sIgE In Multisensitised Allergic Patients O. Luengo, M. Labrador, M. Guilarte, T. Garriga, A. Sala, V. Cardona; Hospital Vall d’Hebron, Barcelona, SPAIN. Functional Activity of CD4+ T Cells in Patients with IgE Dependent versus IgE Independent Atopic Dermatitis (AD) G. N. Drannik1, V. V. Driianska1, A. I. Kurchenko1, I. F. Kurchenko1, L. M. DuBuske2; 1National Medical University, Dept. Clinical Immunology and Allergology, Kiev, UKRAINE, 2Immunology Research Institute of New England, Gardner, MA. Clinical Characteristics of Chronic Urticaria (CU) Patients Having Anti- IgE or IgE Receptor Auto- antibodies (Chronic Autoimmune Urticaria) Versus Chronic Idiopathic Urticaria (CIU) Patients without these Auto-antibodies A. Blaziene1, A. Chomiciene1, L. DuBuske2; 1Vilnius University, Clinic of Chest Diseases, Allergology and Radiology, Vilnius, LITHUANIA, 2Immunology Research Institute of New England, Gardner, MA. Reduction of Total IgE by Targeted Coengagement of IgE-BCR and FcgRIIb with Fc-Engineered Antibodies J. Desjarlais, S. Chu, H. Horton, H. Chen, S. Karki, I. Leung, D. Szymkowski; Xencor, Inc., Monrovia, CA. Predictive and Pharmacodynamic Biomarkers of Interleukin-13 Blockade: Effect of Lebrikizumab on Late Phase Asthmatic Response to Allergen Challenge H. Scheerens1, J. R. Arron1, Z. Su1, Y. Zheng1, W. Putnam1, R. W. Erickson1, D. F. Choy1, J. H. Lee1, J. M. Harris1, N. N. Jarjour2, J. G. Matthews1; 1Genentech, South San Francisco, CA, 2University of Wisconsin, School of Medicince and Public Health, Madison, WI. Co-associations between IL33 Gene Variants and Schistosoma mansoni Infection and Asthma L. Gao1, M. I. Araujo2, J. V. Cordell1, N. Rafaels1, C. Vergara1, M. Campbell1, A. V. Grant1, E. V. Ponte2, R. R. Oliveira2, A. A. Cruz2, E. M. Carvalho2, T. H. Beaty3, R. A. Mathias1, K. C. Barnes1; 1Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, MD, 2Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Bahia, BRAZIL, 3Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. A Prospective Sudy of Asthma and its Related Phenotypes L. M. Fine, M. N. Blumenthal; University of Minnesota, Minneapolis, MN.

627 Segmented Filamentous Bacteria Exacerbate Experimental Murine Asthma S. Burgess, M. Wills-Karp; Cincinnati Childrens Hospital Medical Center, Cincinnati, OH. 628 The Common Beta Chain Phosphorylation Axis Controls IL-5 Receptor Sub-cellular Distribution M. Martinez-Moczygemba, J. T. Lei, T. Mazumdar; Texas A&M Health Science Center, Houston, TX. 629 IL-17A Increases Lung Myeloid DC Function In Experimental Allergic Asthma S. Lajoie, I. P. Lewkowich, M. Wills-Karp; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. 630 Airway Epithelial Cells Directly Promote Th2 Cytokine Production in Mast Cells via Production of IL-1a and TSLP D. R. Nagarkar, J. A. Poposki, R. P. Schleimer, A. Kato; Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL. 631 G Protein Coupled Receptor Kinase 3 (GRK3) - Deficient T Cells Demonstrate Enhanced Migration To CXCL12 And CX3CL1 L. R. Rothlein1, R. G. Timoshchenko1, D. J. Fitzhugh2, M. W. McGinnis1, G. Laroche1, D. P. Siderovski1, T. K. Tarrant1; 1University of North Carolina, Chapel Hill, NC, 2University of South Florida, Tampa, FL. 632 Murine Embryonic Stem Cell-Derived Hematopoietic Progenitor Cells Fail to Elicit Allospecific Cytotoxic T Cell Responses In Vitro B. K. Miyake1,2, A. Ahmed1,2, W. Tabayoyong1,2, N. Zavazava1,2; 1University of Iowa Hospitals and Clinics, Iowa City, IA, 2Veterans Affairs Medical Center, Iowa City, IA. 633 Strain Dependent Differences in Magnitude and Timing of Innate Immune Responses to Respiratory Syncytial Virus (RSV) in Human Monocyte Derived Dendritic Cells (MDDC) P. Hillyer, A. Chen, M. Navarro, L. M. Schramm, V. P. Mane, D. M. Gold, N. Raviv, R. L. Rabin; CBER/FDA, Bethesda, MD. 634 pH-Sensitive CLC Channel Provides a Novel Charge Compensation Pathway for Phagocyte NADPH Oxidase X. Wang, R. Gaurav, D. K. Agrawal; Center for Clinical and Translational Sciences, Creighton University School of Medicine, Omaha, NE. 635 Association of Toll-Like Receptor 6 (TLR6) Polymorphism Pro249Ser with Asthma Phenotypes B. Aubin1, J. Meng2, C. Barnes2, B. E. May1, L. J. Rosenwasser2; 1Children’s Mercy Hospital, Kansas City, MO, 2Children’s Mercy Hospital/UMKC SOM, Kansas City, MO.

Detecting Allergen Characteristics and Changing Patterns of Pollen Exposure 4204 Session Time: Monday, March 21, 2011 9:45:00 AM - 10:45:00 AM

636 Allergy-causing Mite Identification based on PCR Amplification of their Ribosomal DNA M. Lombardero1, B. Beroiz2, F. Couso2, F. Ortego2, P. Castañera2, D. Barber1, P. Hernández2; 1ALK-Abelló, S.A., Madrid, SPAIN, 2CIB-CSIC, Madrid, SPAIN. 637 Recombinant doubly-deglycosylated Der p 1 expression in Pichia pastoris G. Salamanca1, H. Ipsen2, R. Gutiérrez1, R. I. Monsalve1; 1ALK-Abelló, Madrid, SPAIN, 2ALK-Abelló, Copenhagen, DENMARK.

Abstracts  AB305

638 Variability Introduced into Allergen Immunoassays during the Dust Extraction Process E. M. King, D. Block, J. Armstrong, S. Filep, M. D. Chapman; INDOOR Biotechnologies Inc., Charlottesville, VA. 639 Quantitation of Aspergillus versicolor Antigen Using ELISA and Fluorescent Multiplex Array Technology B. R. Smith1, S. Kespohl2, I. Sander2, M. Raulf-Heimsoth2, E. M. King1, M. D. Chapman1; 1INDOOR Biotechnologies, Charlottesville, VA, 2Institue for Prevention and Occupational Medicine of the German Social Accident Insurance, Ruhr University, Bochum, GERMANY. 640 House Dust Mites Are Unable to Penetrate or Colonize Suede J. D. Miller; Mission: Allergy, Inc, Hawleyville, CT. 641 Isoallergen Analysis of Pectate Lyases (Amb a 1 and Amb a 2) from Commercial Short Ragweed Pollen A. Nandy, S. Augustin, L. Mitulski, O. Cromwell; Allergopharma Joachim Ganzer KG, Reinbek, GERMANY. 642 Quantification of Group 5 Allergens in Grass Extracts J. Carnés, M. Gallego, V. Iraola, M. López-Matas; Laboratorios LETI S.L., Tres Cantos, SPAIN. 643 Determination Of Group 1 and 2 Isoforms From House Dust Mite Using Different Antibody Based Assays H. Henmar, L. H. Christensen, G. N. Hansen, G. Larsen, L. B. Andersen, K. Bergmann, L. Lund, M. B. Skydtsgaard; ALK-Abelló, Hørsholm, DENMARK. 644 Recombinant Allergens in Diagnostic Resolution: A Comparative Study T. Garriga Baraut1, O. Luengo1, P. Palazzo2, M. LabradorHorrillo1, M. Guilarte1, A. Sala1, A. Mari2, V. Cardona1; 1Vall d’Hebron Hospital, Barcelona, SPAIN, 2Istituto Dermopatico dell’Immacolata IRCCS, Rome, ITALY. 645 Monoclonal Antibody and IgE Binding to Purified Natural Cry j1 S. Wünschmann1, B. P. Brooks1, A. E. Koid1, K. Ichikawa2, M. D. Chapman1; 1INDOOR Biotechnologies Inc., Charlottesville, VA, 2Department of Pediatrics, Institute of Clinical Medicine, Tsukuba, JAPAN. 646 Northern New Mexico Spring Pollen Levels L. D. Bunderson1, P. Van de Water2, J. Luvall3, E. Levetin1; 1The University of Tulsa, Tulsa, OK, 2Fresno State University, Fresno, CA, 3NASA Marshall Space Flight Center, Huntsville, AL. 647 Aerobiology of Juniperus ashei Pollen in Texas and Oklahoma E. Levetin1, L. Bunderson1, P. Van de Water2, J. C. Luvall3; 1University of Tulsa, Tulsa, OK, 2California State University, Fresno, Fresno, CA, 3NASA Marshall Space Flight Center, Huntsville, AL. 648 Ragweed Pollen Allergy in Austria: a Retrospective Analysis of Sensitization Rates from 1997 to 2007 W. Hemmer1, U. Schauer2, A. Trinca2, C. Neumann3, R. Jarisch1; 1Floridsdorf Allergy Center, Vienna, AUSTRIA, 2Office of the Provincial Government of Niederösterreich, Dept. of Environmental Health, St. Pölten, AUSTRIA, 3Office of the Provincial Government of Niederösterreich, Dept. of Regional Development & Policy, Statistics Unit, Maria Enzersdorf, AUSTRIA. 649 Correlation between Atmospheric Grass Pollen Levels and Three Weather Variables during 2002-2004 in a Tropical Urban Area A. M. Cepeda1,2, M. Wilson1, S. E. Villalba1,2, H. Avila1, J. Hahn1; 1Universidad del Norte, Barranquilla, COLOMBIA, 2Universidad Metropolitana, Barranquilla, COLOMBIA. 650 Correlation between Atmospheric Tree Pollen Levels with Three Weather Variables during 2002-2004 in a Tropical Urban Area M. D. Wilson1, S. E. Villalba1,2, H. Avila1, J. Hahn1, A. M. Cepeda1,2;

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J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB306 Abstracts

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1Universidad del Norte, Barranquilla, COLOMBIA, 2Universidad Metropolitana, Barranquilla, COLOMBIA. Allergenic Profile Differences In Individuals Sensitized To House Dust And Storage Mites In Different Climatic And Geographical Areas V. Iraola1, M. Morales1, A. Huertas2, M. Boquete3, F. Rodriguez4, J. Bartra5, M. Paniagua6, S. Díaz Angulo4, F. Carballada3, J. Carnes1; 1Laboratorios LETI S.L., Tres Cantos, SPAIN, 2Hospital Santa María del Rosell, Cartagena, SPAIN, 3Hospital Xeral de Calde, Lugo, SPAIN, 4Hospital de Valdecilla, Santander, SPAIN, 5Hospital Clínico de Barcelona, Barcelona, SPAIN, 6Hospital San Pere Clavert, Barcelona, SPAIN. IgE Reactivity Profiles in Patients with Asthma and/or Rhinitis Allergic to Cockroach and Mites G. Bardini1, A. C. S. Santos1, K. S. Santos2, L. K. Arruda1; 1School of Medicine of Ribeirao Preto, Ribeirao Preto, BRAZIL, 2University of Sao PauloSchool of Medicine, Sao Paulo, BRAZIL. Preliminary Data On Oral Allergy Syndrome/Profilin Sensitization In An Australian Population P. K. Burton1,2, C. H. Katelaris1,2; 1Campbelltown Hospital, Campbelltown, NSW, AUSTRALIA, 2University of Western Sydney, Macarthur, NSW, AUSTRALIA. Correlation Between Self-reported Rhino-conjunctivitis Symptoms During Allergen Exposure and Allergic Sensitization in Patients with Chronic Rhino-conjunctivitis N. Saengsawang, P. Vatanasurkitt, J. Ngamphaiboon, P. Chatchatee; King Chulalongkorn Memorial Hospital, Bangkok, THAILAND. Grass and Olea Airborne Pollen Allergens in Outdoor Air Samples and its Correlation with Pollen Counts S. Ladeira1, C. Nunes1, R. Ferro2, R. Ferro2, M. Martins2, E. Caeiro2, C. Antunes2, R. Brandao2, A. Caldeira2; 1Center of Allergy of Algarve, Portimao, PORTUGAL, 2University, Evora, PORTUGAL. Pollen Viability under a Stress Condition R. Codina, R. E. Esch, T. C. Coyne; Greer Laboratories, Lenoir, NC. Grasses Pollen Concentrations In The Atmosphere Of Portugal E. Caeiro1, C. Nunes2, R. Brandao3, L. Lopes3, A. Gaspar4, M. Almeida4; 1University of Evora, Portimao, PORTUGAL, 2Center of Allergy of Algarve, Portimao, PORTUGAL, 3University of Evora, Evora, PORTUGAL, 4CUF Descobertas, Lisboa, PORTUGAL. Evolution of Relative Abundance of Various Tree, Grass and Weed Pollens in Vinnitsa, Ukraine, from 1999 to 2010 as an Index of Climate Change V. Rodinkova1, O. Bilous1, L. Kremenska1, O. Palamarchuk1, L. M. DuBuske2; 1Vinnitsa National Medical University, Vinnitsa, UKRAINE, 2Immunology Research Institute of New England, Gardner, MA. The Revision of Allergic Pollen Calendar and an Algorithm of Pollen Count Prediction in Korea J. Kim1, J. Oh1, H. Lee2, I. Kang3, J. Cheong4, S. Kim5, K. Park6, M. Kook7, B. Kim8; 1Hanyang University Guri Hospital, Guri-si, KOREA, REPUBLIC OF, 2Hanyang University Hospital, Seoul, KOREA, REPUBLIC OF, 3Daegu Fatima Hospital, Daegu, KOREA, REPUBLIC OF, 4Korea University Hospital, Seoul, KOREA, REPUBLIC OF, 5Busan St. Maria Hospital, Busan, KOREA, REPUBLIC OF, 6Jeonju Jesus Hospital, Jeonju, KOREA, REPUBLIC OF, 7Kwangju Veteran’s Hospital, Kwangju, KOREA, REPUBLIC OF, 8Kangneung Asan Hospital, Kangneung, KOREA, REPUBLIC OF. Atmospheric Characteristics And Potential Allergenic Pollen Dispersal P. K. Van de Water; Calirfornia State University Fresno, Fresno, CA.

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

Epidemiology of Asthma: Patterns of Disease in Response to Environmental and Occupational Allergens 4205 Session Time: Monday, March 21, 2011 9:45:00 AM - 10:45:00 AM

661 Poorly Controlled Asthma Among High Risk Children Living in a Rural Environment T. T. Perry1,2, M. Rettiganti1,3, R. H. Brown1, D. R. Watkins1, T. G. Nick1, A. McCracken1, S. M. Jones1,2; 1University of Arkansas for Medical Sciences, Little Rock, AR, 2Arkansas Children’s Hospital Research Institute, Little Rock, AR, 3The Ohio State, Columbus, OH. 662 Oral Contraceptive Use Before Pregnancy and Respiratory Outcomes in the Offspring: Comparison of Estrogen-Progestin Combined Pills and Progestin-Only Pills D. B. Hancock1, S. E. Haberg2, K. Furu2,3, K. W. Whitworth1, P. Nafstad2,4, W. Nystad2, S. J. London1; 1NIEHS, Research Triangle Park, NC, 2Norwegian Institute of Public Health, Oslo, NORWAY, 3University of Tromso, Tromso, NORWAY, 4University of Oslo, Oslo, NORWAY. 663 Cockroach Exposure, Independent of Sensitization Status, is Associated with Hospitalization for Asthma in Inner-city Children J. C. Carlson, F. A. Rabito; Tulane University, New Orleans, LA. 664 Maternal Diet during Pregnancy and Wheeze and Eczema in Infants; the Japanese Birth Cohort (T-CHILD) Study M. Narita1, D. Qiu2, M. Hamaguchi1, M. Doi1, M. Futamura1, N. Sakamoto2, Y. Ohya1,3; 1Division of Allergy, National Center for Child Health and Development, Tokyo, JAPAN, 2Division of Epidemiology, National Research Institute for Child Health and Development, Tokyo, JAPAN, 3Tokyo-Children’s Health, ILlness and Development (T-CHILD) study group, Tokyo, JAPAN. 665 How Often Do Allergy Symptoms Precede Allergen Sensitization? S. mela, J. Spahn, M. Krawiec; National Jewish, DENVER, CO. 666 Risks for asthma at age 7 differ by neighborhood and socioeconomic status in New York City L. M. Acosta1, R. L. Miller2, I. F. Goldstein3, A. G. Rundle3, R. B. Mellins4, A. G. Cornell4, L. Hoepner1, H. Andrews5, S. Lopez-Pintado6, J. W. Quinn7, G. L. Chew1, J. S. Jacobson3, F. P. Perera1, M. S. Perzanowski1; 1 Columbia University, Mailman School of Public Health, Department of Environmental Health Sciences, New York, NY, 2Columbia University, Department of Medicine, Division of Pulmonary, Allergy, Critical Care Medicine, New York, NY, 3 Columbia University, Mailman School of Public Health, Department of Epidemiology, New York, NY, 4Columbia University, College of Physicians and Surgeons, Department of Pediatrics, New York, NY, 5Columbia University, Mailman School of Public Health, Data Coordinating Center, New York, NY, 6Columbia University, Mailman School of Public Health, Department of Biostatistics, New York, NY, 7 Columbia University, Institute for Social and Economic Research and Policy, New York, NY. 667 Clinical Characteristics of Patients with Vocal Cord Dysfunction in a Tertiary Care Adult Allergy/Immunology Outpatient Clinic C. K. Rao, M. Mahdavinia, M. Fajt, A. Petrov; University of Pittsburgh Medical Center, Pittsburgh, PA.

668 Allergen Sensitization and the Risk of Asthma and Eczema in Children in the Pittsburgh Area B. McHugh, A. MacGinnitie; Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA. 669 Follow-up Of Wheezing In Preschool Children From The Southern Region Of Sã Paulo, Brazil: International Study Of Wheezing In Infants - Phase 2 A. C. C. Dela Bianca1, G. F. Wandalsen1, J. Mallol2, D. Solé1; 1Universidade Federal de São Paulo - UNIFESP, São Paulo - SP, BRAZIL, 2Universidade of Santiago, Santiago, CHILE. 670 Asthma Severity and Allergen Sensitization: Trends in the Past 5 Years A. Yuenyongviwat, M. Piemwattathaporn, P. Sangsupawanich; Allergy and Immunology Unit, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, THAILAND. 671 A Preliminary Retrospective Analysis of Risk Factors Associated with Asthma Exacerbations N. N. Cac1, F. Abrahamian2, D. C. Jerome3; 1University of California at Irvine, Irvine, CA, 2Kaiser Permanente, Bellflower, CA, 3Veterans Affairs Medical Center, Long Beach, CA. 672 Prevalence of Mold Sensitization in Lebanese Children with Respiratory Allergies Z. E. Baz; St George Hospital University Medical Center- University of Balamand, Achrafieh-Beirut, LEBANON. 673 The Relationship Of Sensitization And Specific IgE With Age In A Pediatric Population With Asthma M. Serota, C. Barnes, J. Meng; Children’s Mercy Hospital, Kansas City, MO. 674 Prevalence of Allergies in Children with Orthodontic Braces In The Dominican Republic A. J. Castillo1, J. De Peña1, A. Peña1, E. Fernandez-Caldas2; 1Allergy & Asthma Center, Santo Domingo, DOMINICAN REPUBLIC, 2Inmunotek, S. L., Madrid, SPAIN. 675 Weather Changes Are Perceived as a Common Trigger in Asthma Patients E. E. Clarke, D. A. Khan; University of Texas Southwestern Medical Center, Dallas, TX. 676 Asthma, a Risk Factor For Heart Disease? D. R. Sun1, C. Xu2; 1Virginia Commonwealth University, Richmond, VA, 2VHQC, Richmond, VA. 677 Characteristics of a Novel Allergen of Samba Wood A. Aranda 1, P. Campo 2, A. Palacin 3, A. Diaz-Perales 3, J. Rodriguez-Bada1, G. Salcedo3, M. Blanca2; 1Fundacion Imabis-Carlos Haya Hospital, Malaga, SPAIN, 2Carlos Haya Hospital, Malaga, SPAIN, 3Unidad de Bioquimica, Departamento de Biotecnología, E.T.S. Ingenieros Agronomos, Madrid, SPAIN. 678 Environmental Chemical Exposure May Augment Occupational Asthma S. E. Anderson, J. Franko, D. Beezhold, B. J. Meade; CDC/NIOSH, Morgantown, WV. 679 Increasing the Ability to Correctly Identify Latex Sensitized Patients Using Serologic Tests K. J. Kelly1, D. J. Accetta1, M. Klancnik1, N. Elms1, M. L. Wang2, R. G. Hoffmann1, V. P. Kurup1; 1Medical College of Wisconsin, Milwaukee, WI, 2National Institute for Occupational Safety and Health, Morgantown, WV. 680 Hypersensitivity Reactions to Marijuana P. Basharat1, G. Sussman2, D. Beezhold3, N. Leader2; 1 University of Western Ontario, London, ON, CANADA, 2University of Toronto, Toronto, ON, CANADA, 3NIOSH, Morgantown, WV.

Abstracts  AB307

681 Fusarium Graminae Mold Causes Epidemics In Wheat Loss And Fusarium Sensitization In Farming Communities D. Dalan1, W. Brown2; 1Allergy & Asthma Care Center, Fargo, ND, 2North Dakota State University, Fargo, ND. 682 Sick Building Syndrome (SBS) Among Office Workers and Exposure to Indoor Fungal Allergens in Rio de Janeiro, Brazil J. L. Boechat1, J. L. Rios2, M. C. Ramos1, R. R. Luiz1, F. R. Aquino Neto1, J. R. Lapa e Silva1; 1Federal University of Rio de Janeiro, Rio de Janeiro, BRAZIL, 2Federal University of Rio de Janeiro, Rio de Janeiro, BRAZIL. 683 Omalizumab In The Treatment Of Severe Persistent Bakers Asthma. M. Ruiz Garcia, M. Fernandez Nieto, L. Manso Alonso, J. Sastre Dominguez; Fundación Jiménez Díaz, Madrid, SPAIN. 684 Occupational Contact Dermatitis to Penicillium molds on Salami Skin F. Wantke1, B. Simon-Nobbe2, V. Pöll2, M. Götz1, R. Jarisch1, W. Hemmer1; 1Floridsdorf Allergy Center, Vienna, AUSTRIA, 2Dept. of Cell Biology/Genetics, University of Salzburg, Salzburg, AUSTRIA.

Food Allergy & Diagnostic Tests 4206 Session Time: Monday, March 21, 2011 9:45:00 AM - 10:45:00 AM

685 IgE and IgG4 Epitope Mapping by Peptide Microarray Immunoassay for the Identification of Patients with Symptomatic Peanut Allergy J. Lin1, F. M. Bruni2, Z. Fu1, J. Maloney1, L. Bardina1, G. Gimenez1, A. L. Boner2, H. A. Sampson1; 1Mount Sinai School of Medicine, New York, NY, 2University of Verona, Verona, ITALY. 686 IL-33 Is Produced And Responded To At Elevated Levels In Peanut Allergic Humans K. T. HayGlass, J. Xie, R. Chooniedass, A. B. Becker, E. R. Simons; Univ Manitoba, Winnipeg, MB, CANADA. 687 Evidence for False-Negative Open Food Challenges J. A. Lieberman, H. A. Sampson; Mount Sinai School of Medicine, New York, NY. 688 Do Baseline Serum Total Tryptase Levels Predict Severity Of Food Allergy Reactions? D. K. Mansoor1, H. Sharma1, J. Myles2, Y. Jiang2, B. Torretti2, L. B. Schwartz3, M. McMorris2, C. Akin4; 1Children’s National Medical Center, Washington, DC, 2University of Michigan, Ann Arbor, MI, 3Virginia Commonwealth University, Richmond, VA, 4Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. 689 Lymphocyte Proliferation Response With Food Antigen May Help In Diagnosing Immediate Type Gastrointestinal Food Allergy Symptoms K. Kuzume 1,2, Y. Teduka 1, T. Moritani 1, Y. Murakami 1, M. Koizumi1, E. Ishii1; 1Ehime Graduated University School of Medicine, Toon, Ehime,, JAPAN, 2Ehime Prefectural Niihama Hospital, Niihama, Ehime, JAPAN. 690 Proteomic Analysis Of Food Allergencity In RAST Positive Patients With Food Allergies J. P. Wheeler, Jr, B. Nair, J. Reynolds, D. E. Sykes, S. Mahajan, S. Schwartz; University of Buffalo, Buffalo, NY.

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AB308 Abstracts

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691 Diagnosis and Management of Childhood Food Allergies at an Academic Medical Center S. H. Desai, T. D. Green; Children’s Hospital of Pittsburgh, Pittsburgh, PA. 692 Use of Food Challenge to Distinguish Food Protein-Induced Enterocolitis Syndrome from Hereditary Fructose Intolerance M. A. Ruffner1, D. N. Finegold2, A. J. MacGinnitie2; 1University of Pittsburgh School of Medicine, Pittsburgh, PA, 2Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA. 693 Detection Of Milk-specific IgE And IgA In Stool Samples From Children With Food Allergy C. Berin, S. Wood, I. Lopez-Exposito, H. Sampson, A. NowakWegrzyn; Mount Sinai School of Medicine, New York, NY. 694 Allergen Patch Test In Children With Food Allergy-related Gastrointestinal Symptoms N. VISITSUNTHORN, O. BOONYAVIWAT, P. PACHARN, O. PIBOONPOCANUN, P. VICHYANOND; SIRIRAJ HOSPITAL, MAHIDOL UNIVERSITY, BANGKOK, THAILAND. 695 Treatment With Antacid Medication Increases Odds Of Diagnosis Of Food Allergy K. A. DeMuth, A. Stecenko, K. Sullivan, A. Fitzpatrick; Emory University, Atlanta, GA. 696 IgE Reactivity To Food And Latex Components In Sera From Chestnut Allergic Individuals From The Mediterranean Area S. Sjolander, E. Rahl, M. Poorafshar, P. Brostedt; Phadia AB, Uppsala, SWEDEN. 697 Measurement of IgE Antibodies to Peanut Component Proteins Distinguishes Clinical Peanut Allergy from Asymptomatic Sensitization X. Hong1, D. M. Caruso1, J. S. Birne1, J. L. Schanta1, R. Kumar2, X. Liu1, J. A. Pongracic2, X. Wang1; 1The Mary Ann and J. Milburn Smith Child Health Research Program, Children’s Memorial Research Center, Chicago, IL, 2Division of allergy and Immunology, Children’s Memorial Hospital, Chicago, IL. 698 Do Egg-specific IgE Levels Predict Reactions to Seasonal Influenza or H1N1 Vaccination? V. L. Paschall, R. I. Siles, H. Bhatti, P. J. Nolder, A. L. Melton; Cleveland Clinic Foundation, Cleveland, OH. 699 Purified Natural Ara h 6: An Important Marker for IgE Responses to Peanut A. E. Koid1, M. D. Chapman1, R. G. Hamilton2, S. Wünschmann1; 1INDOOR Biotechnologies, Inc., Charlottesville, VA, 2Johns Hopkins University School of Medicine, Baltimore, MD. 700 New Insights On the Predictors Of Outcome on Cow’s Milk Food Challenges N. B. Richards1,2, E. Yousef1,2, S. McGeady1,2, J. Hossain2; 1Thomas Jefferson Hospital, Philadelphia, PA, 2A.I. DuPont Hospital, Wilmington, DE. 701 Diagnostic Value of Component Allergen, Pru p 1 in the Korean Adult Patients with Birch Pollen-Associated Food Allergy E. Hwang, J. Kim, J. Kim, H. Jin, Y. Ye, H. Park; Ajou University School of Medicine, Suwon, KOREA, REPUBLIC OF. 702 Clinical Significance Of Serum Specific IgE to Bovine Serum Albumin(BSA) In Patients With Meat Induced Food Allergy H. Jin1, J. Kim1, J. Kim1, E. Hwang1, G. Choi1, Y. Ye1, H. Park1, Y. Lee2; 1 Ajou University School of Medicine, Suwon, KOREA, REPUBLIC OF, 2GF clinic, Seoul, KOREA, REPUBLIC OF. 703 Relationship Between Clinical and Laboratory Criteria and Results of Double Blind Placebo Controlled Food challenge (DBPCFC) for the IgE Mediated Cow’s Milk Allergy Diagnosis in Pediatric Patients

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A. K. F. GUSHKEN, G. H. YONAMINE, A. P. B. M. CASTRO, U. DORIA-FILHO, A. C. BRANDÃO, C. M. L. BECK, L. A. WATANABE, A. B. F. FOMIN, A. C. PASTORINO, C. M. A. JACOB; INSTITUTO DA CRIANÇA, SAO PAULO, BRAZIL. Can Initial Food Reaction Severity be Predictive of Oral Food Challenge Outcome? J. P. Garrett, J. M. Spergel, A. Cianferoni; Children’s Hospital of Philadelphia, Philadelphia, PA. A Systematic Evaluation of the Cork-Southampton Food Challenge Outcome Calculator in a Canadian Sample. L. M. Segal1, J. O. B. Hourihane2, A. Clarke1, R. Alizadehfar1, J. Lucas3, G. Roberts3, M. Lajeunesse3, A. DunnGalvin4; 1McGill University, Montreal, QC, CANADA, 2University College Cork, Cork, IRELAND, 3Southampton University, Southampton, UNITED KINGDOM, 4 Cork University Hospital, Cork, IRELAND. Role of Specific IgE and Skin Prick Testing in Predicting Food Challenge Results to Heated Egg C. F. Cortot, W. J. Sheehan, S. N. Baxi, A. F. Dioun, L. C. Schneider, W. Phipatanakul; Children’s Hospital, Boston, MA. Variability of Commercially Available Sesame Skin Prick Test Reagents L. Katz1, R. J. Sporter2, M. A. Cavuoto1, V. Bonagura1,3, J. A. DeVoti1,4, D. W. Rosenthal1,3; 1Division of Allergy and Immunology North Shore LIJ Health System, Great Neck, NY, 2Department of Medicine, North Shore LIJ Health System, Great Neck, NY, 3Hofstra North Shore-LIJ School of Medicine, Manhasset, NY, 4Feinstein Institute for Medical Research, Great Neck, NY. In Vitro Evidence Of The Synergistic Effect Of Non Steroidal Anti Inflammatory Drugs (NSAIDs ) Into Ig-E Mediated Food Allergy Response In Basophils J. Bartra, M. Pascal, R. Vilella, J. Mila, R. Muñoz-Cano, J. Sanchez-Lopez, A. Valero, c. Picado; Hospital Clinic, Barcelona, Barcelona, SPAIN. Oral Food Challenges in 1 Year Old Infants Using PreDetermined Challenge Criteria K. J. Allen1,2,3,4, J. J. Koplin1,2, S. Almer1, D. Dawson1, T. Dang1,2, S. Dharmage5, L. Gurrin5, D. Hill1, A. Lowe5, M. Matheson5, P. Martin 1,2 , L. Miles 1, N. Osborne 1,2 , A. Ponsonby 1,2 , M. Robertson3, M. Slaa1, M. Sutherland1, T. Tan1,2, M. Tang1,2,3, D. Tey3, L. Thiele1, M. Wake1; 1Murdoch Childrens Research Institute, Melbourne, AUSTRALIA, 2Dept of Paediatrics, University of Melbourne, Melbourne, AUSTRALIA, 3Dept of Allergy & Immunology, Royal Children’s Hospital, Melbourne, AUSTRALIA, 4Dept of Gastroenterology & Clinical Nutrition, Royal Children’s Hospital, Melbourne, AUSTRALIA, 5School of Population Health, The University of Melbourne, Melbourne, AUSTRALIA. An Immunoassay to Measure IgE to Galactose alpha 1,3 Galactose Associated with Red Meat Allergies L. Flebbe-Rehwaldt1, H. Wells1, S. Roberts1, P. Walters1, M. Ling1, C. Brockus1, J. F. Halsey1, H. James2, S. Commins2, T. Platts-Mills2, M. Altrich1; 1Viracor-IBT Laboratories, Lenexa, KS, 2University of Virginia Health System, Charlottesville, VA. Descriptive Analysis of Frequency and Severity of Meat Sensitivity in Tick-bitten Patients in a Northern Virginia Allergy Practice J. Gadde, D. Gadde, L. Grooms, P. Dauby, D. Beakes, P. S. Creticos; Allergy & Asthma Specialists of Greater Washington, Warrenton, VA. Prevalence of Food Allergy Among Preschool Children in Northern Thailand M. Lao-araya, M. Trakultivakorn; Chiang Mai University, Chiang Mai, THAILAND.

Abstracts  AB309

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

Drug Allergy 4207 Session Time: Monday, March 21, 2011 9:45:00 AM - 10:45:00 AM

722 Skin Test Predictive Value On The Proton Pump Inhibitors Allergy P. Bonadonna1, M. Pagani2, A. Bircher3, K. Scherer3, B. Caruso4, C. Cocco5, M. Schiappoli1, G. Senna1, C. Lombardo1; 1Allergy Unit Verona General Hospital, Verona, ITALY, 2Allergy and Oncology Department, Mantova, ITALY, 3Allergy Unit, Department of Dermatology University Hospital Basel, Basel, SWITZERLAND, 4Laboratory of Clinical Chemistry and Haematology Verona General Hospital, Verona, ITALY, 5Laboratory of Clinical Chemistry and Haematology Verona General Hospital, Verona, ITALY. 723 Low-dose Aspirin Desensitization in Patients with Acute Coronary Syndromes F. L. Chia, B. Y. Thong, K. P. Leong, J. W. Tan, G. Chan, T. C. Tan, S. C. Tan, C. Y. Tang, J. F. Hou, H. H. Chng; Tan Tock Seng Hospital, Singapore, SINGAPORE. 724 The Most Important Sensitizing Drug In Ocular Examination: 1-Year Study M. E. LANDIVAR, P. F. JARA, E. HERNANDEZ, J. SASTRE; FUNDACION JIMENEZ DIAZ, MADRID, SPAIN. 725 Tolerance to Carbapenems and Cephalosporins in Penicillin Allergic Patients E. MORENO, J. BATISTA, B. HIERRO, V. PONCE, A. GONZALEZ, I. DAVILA; UNIVERSITY HOSPITAL OF SALAMANCA, SALAMANCA, SPAIN. 726 Potential Involvement Of Lipoxygenase Pathway Polymorphisms In Hypersensitivity To NSAIDs L. R. Jagemann1, J. A. Cornejo-Garcia1, N. Blanca-Lopez2, I. Doña3, J. Fernandez4, J. J. Laguna5, A. Rosado6, R. M. RodriguezGueant7, J. L. Gueant7, G. Canto2, M. Blanca3; 1Fundacion IMABIS, Malaga, SPAIN, 2Servicio de Alergologia, Hospital Infanta Leonor, Madrid, SPAIN, 3Servicio de Alergologia, Hospital Carlos Haya, Malaga, SPAIN, 4Servicio de Alergologia, Hospital de Elche, Alicante, SPAIN, 5Servicio de Alergologia, Hospital de la Cruz Roja, Madrid, SPAIN, 6Unidad de Alergia, Hospital de Alcorcon, Madrid, SPAIN, 7CHU de Brabois, Nancy, FRANCE. 727 A Descriptive Analysis of Oral Drug Challenges in NSAIDinduced Urticaria, Angioedema and Anaphylaxis T. Chaudhry1, W. Smith1, F. Kette1, R. Heddle1,2; 1Royal Adelaide Hospital, Adelaide, AUSTRALIA, 2SA Pathology, Adelaide, AUSTRALIA. 728 Immunological Study of Non Immediate Allergic Reaction to Infliximab C. Mayorga1, M. J. Torres2, M. J. Sanchez1, I. Doña2, C. Rondon2, M. D. Ruiz2, P. Campo2, M. Salas2, M. Blanca2; 1Fundacion IMABIS-Carlos Haya Hospital, Málaga, SPAIN, 2Carlos Haya Hospital, Málaga, SPAIN. 729 Adverse Drug Reactions In Children; Clinical And Laboratory Characteristics G. Karakoc, D. Dogruel, D. Altintas, M. Yilmaz, S. Kendirli; Cukurova University, Adana, TURKEY. 730 Physician Approaches to Beta-lactam Use in Patients with Penicillin Hypersensitivity T. Prematta, F. Ishmael; Penn State Hershey Medical Center, Hershey, PA.

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713 Gender Differences in the Direct, Indirect, and Socio-Emotional Costs of Living and Seeking Healthcare for Adults with and without Food-Sensitivity M. Fox1, M. Mugford1, L. Frewer2, J. Voordruw3, J. O. B. Hourihane1, A. DunnGalvin1; 1 University College Cork, Cork, IRELAND, 2 Wagingen Universiteit, Wagingen, NETHERLANDS, 3Wagengin Universiteit, Wagengin, NETHERLANDS. 714 Increase in Multiple Nut Reactivity with Increasing Age is Not an Artefact of Incomplete Allergy Testing H. A. Brough1, J. Costa2, M. Penagos1, D. F. Haddad 3, L. Davidson2, H. Peachey3, G. Lack1; 1King’s College London, London, UNITED KINGDOM, 2Guy’s and St. Thomas’ Hospital, London, UNITED KINGDOM, 3St. Peter’s Hospital, Chertsey, UNITED KINGDOM. 715 Immediate Type Food Allergy At Twelve Months Old Does Not Associated With Timing of Introduction of Weaning Diet But Associated With Episodes of Eczema and Gastroenteritis Y. Ohya, M. Narita, M. Futamura, N. Sakamoto, H. Saito; National Center for Child Health and Development, Tokyo, JAPAN. 716 Concomitant Allergic Diseases in Persons with Peanut and Tree Nut Allergy in a Population Based Survey F. Huang, H. A. Sampson, S. H. Sicherer; Mt. Sinai School of Medicine, New York, NY. 717 A Study for Correlation between Food Allergen Sensitization and their Clinical Manifestations in Korean Children B. Pyun1, Y. Jeon1, H. Yang1, H. Yum2, K. Ahn3, S. Lee4, K. Kim5, T. Song6, W. Kim7, J. Kim8; 1Soonchunhyang University Hospital, Seoul, KOREA, REPUBLIC OF, 2Seoul Medical Center, Seoul, KOREA, REPUBLIC OF, 3Samsung Medical Center, Seoul, KOREA, REPUBLIC OF, 4Ajou University Hospital, Suwon, KOREA, REPUBLIC OF, 5Severance Hospital, Seoul, KOREA, REPUBLIC OF, 6Ilsan Paik Hospital, Goyang, KOREA, REPUBLIC OF, 7Seoul Paik Hospital, Seoul, KOREA, REPUBLIC OF, 8Inha University Hospital, Incheon, KOREA, REPUBLIC OF. 718 Comparison of Adult and Pediatric Self-Reported Food Allergy Prevalence in an Inner City Population G. Dapul-Hidalgo, R. Joks, S. Kumar; Center for Asthma and Allergy Research, SUNY Downstate Medical Center, Brooklyn, NY. 719 DOHaD and Allergic Diseases in Schoolchildren: Does IUGR Affect Risk of Allergic Diseases? K. Mukaida1,2, T. Kusunoki1,3, T. Morimoto4, M. Sakuma4, N. Mito1, T. Yasumi3, T. Fujii1, R. Nishikomori3, T. Heike3; 1Department of Pediatrics, Shiga Medical Center for Children, Shiga, JAPAN, 2Kumiko Allergy clinic, Kyoto, JAPAN, 3Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, JAPAN, 4Center for Medical Education, Graduate School of Medicine, Kyoto University, Kyoto, JAPAN. 720 Goat and Sheep’s Milk Allergy With Cow’s Milk Tolerance. A Case Report M. Cabanillas Platero1, M. Piñero Saavedra2; 1Department of Pediatric AllergyVirgen del Rocio Hospital, Sevilla, SPAIN, 2Department of Allergy, Virgen del Rocio Hospital, Sevilla, SPAIN. 721 Systemic Mastocytosis Presenting as Prinzmetal (Variant) Angina B. R. Ward, L. B. Schwartz; Virginia Commonwealth University Health System, Richmond, VA.

AB310 Abstracts

MONDAY

731 Immediate Hypersensitivity Reactions To Quinolones N. Blanca-López1, M. Torres2, M. Seoane1, F. Ruano1, I. Doña3, M. Garcimartin1, M. Vazquez1, R. Barranco1, M. Blanca3, G. Canto1; 1Hospital Infanta Leonor, Madrid, SPAIN, 2Hopital Carlos Haya, Malaga, SPAIN, 3Hospital Carlos Haya, Malaga, SPAIN. 732 Nano-technological Improvement in the Design of Radioimmunoassay to Detect IgE to Betalactams by Using Oligo(ethylenglycol)-Spacer to anchor Dendrimeric Conjugates to a Solid Phase M. I. Montañez1, E. Perez-Inestrosa2, R. Suau2, C. Mayorga1, J. L. Rodriguez-Bada1, M. J. Torres3, M. Blanca3; 1IMABIS Foundation-Carlos Haya Hospital, Malaga, SPAIN, 2Organic Chemistry, Faculty of Science, Universidad de Malaga, Malaga, SPAIN, 3Allergy Service, Carlos Haya Hospital, Malaga, SPAIN. 733 Prostaglandins Receptors Polymorphisms In Patients With NSAIDs-induced Urticaria J. A. Cornejo-Garcia1, L. R. Jagemann1, I. Doña2, N. BlancaLopez3, J. J. Laguna4, J. Fernandez5, A. Rosado6, S. Terrados7, M. Gandolfo8, M. Blanca2, G. Canto3; 1Fundacion IMABIS, Malaga, SPAIN, 2Servicio de Alergologia, Hospital Carlos Haya, Malaga, SPAIN, 3Servicio de Alergologia, Hospital Infanta Leonor, Madrid, SPAIN, 4Servicio de Alergologia, Hospital de la Cruz Roja, Madrid, SPAIN, 5Servicio de Alergologia, Hospital de Elche, Alicante, SPAIN, 6Unidad de Alergia, Hospital de Alcorcon, Madrid, SPAIN, 7Servicio de Alergologia, Hospital Ramon y Cajal, Madrid, SPAIN, 8Unidad de Alergia, Hospital de Fuenlabrada, Madrid, SPAIN. 734 Diagnostic Procedures Of Delayed-type Hypersensitivity (DTH) Reactions To Low Molecular Weight Heparins (LMWHs) C. VILA, A. ROSADO, W. L. ALMANZAR, M. M. MORO, M. D. ALONSO, M. ACOSTA; HOSPITAL UNIVERSITARIO FUNDACION ALCORCON, ALCORCON (MADRID), SPAIN. 735 Adverse Drug Reactions to Cephalosporins in Penicillin Allergic Pediatric Patients K. A. Ahmed, S. J. Fox, M. A. Park, MD; Mayo Clinic, Rochester, MN. 736 Shellfish Allergy and Contrast Media S. M. Hamshere, P. Pfeffer, R. Ali; Department of Respiratory Medicine, London, UNITED KINGDOM. 737 Response To Nasal Challenge With Lysine-aspirin In Subjects With Hypersensitivity Reactions To Nsaids With Respiratory Versus Cutaneous Involvement M. Blanca1, P. Campo1, C. Rondon1, J. Cornejo2, I. Doña1, L. Haggeman2, M. Torres1, L. Melendez2, J. Rodriguez-Bada2, G. Canto3; 1Hospital Carlos Haya, Malaga, SPAIN, 2IMABIS Foundation, Malaga, SPAIN, 3Hospital Infanta Leonor, Madrid, SPAIN. 738 Allergy to Sulfonamide Antibiotics and Sulfonamide Nonantibiotics in systemic lupus erythematosus and Sjögren syndrome Y. Suyama; St lukes international hospital, Tokyo, JAPAN. 739 Cisplatin can be Safely Administered After Hypersensitivity to Carboplatin K. N. Syrigos1, N. Makrilia1, E. Politi1, I. Kaklamanos1, M. W. Saif2, E. I. Syrigou1; 1Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens School of Medicine, Greece, Athens, GREECE, 2Clinical Medicine, Columbia University College of Physicians

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and Surgeons/GI Oncology Section of the Division of Hematology/ Oncology, Herbert Irving Comprehensive Cancer Center, Milstein Hospital, New York, NY. IgE-Mediated Reactions to Local Anesthetics: a Case Report M. C. Stahl, R. Gomez, K. Waibel; Wilford Hall Medical Center, Lackland Air Force Base, TX. Allergy To Rocuronium: From Clinical Suspicion To Correct Diagnosis J. Leysen, M. Vercauteren, J. Lambert, J. J. Weyler, C. H. Bridts, L. S. De Clerck, W. J. Stevens, D. G. Ebo; University of Antwerp, Antwerpen, BELGIUM. Analysis of the Efficacy of Corticosteroid Therapy in Drug Induced Hypersensitivity Syndrome S. Yee, S. P. Jariwala, D. L. Rosenstreich, E. Jerschow; Montefiore Medical Center, Bronx, NY. Allergenicity of Topical Flucinolone Acetonide 0.01% in Peanut Oil in a Patient Previously Sensitized to Peanuts M. Shams1, R. Kado1, S. J. Maleki2, C. Mattison2, J. El-Dahr1; 1Tulane University School of Medicine, New Orleans, LA, 2United States Department of Agriculture-Agriculture Research Science, New Orleans, LA. Clinical Value Of Skin Tests In Predicting Hypersensitivity Reactions To Radiocontrast Media W. Song1,2, M. Kim1,2, S. Lee1,2, T. Kim1,2, S. Kim1,3, H. Kang1,2, H. Park1,2, S. Kim1,2, Y. Chang1,3, S. Cho1,2, S. Chang4, K. Min1,2, Y. Kim1,5; 1Department of Internal Medicine, Seoul National University Hospital, Seoul, KOREA, REPUBLIC OF, 2Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, KOREA, REPUBLIC OF, 3Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, KOREA, REPUBLIC OF, 4Department of Internal Medicine, Sung-Ae General Hospital, Bucheon, KOREA, REPUBLIC OF, 5Eulji Medical Center, Seoul, KOREA, REPUBLIC OF. Angiotensin Coverting Enzyme Inhibitors: Managing drug allergic cross-reactivity P. Poza-Guedes, R. González-Pérez, V. Matheu; HUNS La Candelaria, Santa Cruz de Tenerife, SPAIN. Sensitization to Penicillin in Adolescents with Rheumatic Fever M. M. R. Felix, F. C. Kuschnir, A. J. L. A. Cunha; Federal University of Rio de Janeiro, Rio de Janeiro, BRAZIL. Misconceptions About Shellfish Allergies And Iodine Radicontrast Media Administration V. VELAZQUEZ, B. DiGiorgi, Y. Hernandez; Hospital Episcopal San Lucas, Ponce, PR. Skin Testing to Clopidogrel and Radiocontrast Media (RCM) to Investigate the Mechanism(s) of Post-Percutaneous Coronary Intervention (PCI) Rashes F. Farrahi1, K. F. von Tiehl2, R. A. Simon1, J. M. Kelso1; 1Scripps Clinic, San Diego, CA, 2Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. Adverse interaction of coconut pertaining to Vitamin D intake L. Yao, A. Satyanarayan; Midwestern University, Glendale, AZ. Rapid Desensitization Did Not Prevent Febrile “Idiosyncratic” Reactions to Oxaliplatin A. Mathew1, M. S. Ballas1, M. Gorsky2, B. A. Feigenbaum1; 1New York University School of Medicine, New York, NY, 2Memorial Sloan-Kettering Cancer Center, New York, NY. Risk Factors for Subjective Symptoms During Drug Challenges L. Kao, D. Khan, R. Gruchalla; UT Southwestern, Dallas, TX.

752 Special Considerations for Rapid Drug Desensitization With Natalizumab M. Sutaria1, K. Miro2, A. Mathew2, I. Kister2, B. A. Feigenbaum2; 1NYU Langone Medical Center, New York, NY, 2New York University School of Medicine, New York, NY. 753 Regulation Of Anticonvulsant-induced T Cell Responsiveness By Cd4+Cd25+Cd127Low Cells In Patients With Drug Allergy Reactions C. Antunez1, M. J. Sanchez-Quintero1, C. Mayorga1, M. J. Torres1, D. Ruíz1, M. Blanca1, A. Romano2; 1Allergy Service and Research Laboratory, Carlos Haya HospitalFundación IMABIS., Málaga, SPAIN, 2Allergy Unit, Complesso Integrato Columbus, Rome, ITALY. 754 Coronary Stent Hypersensitivity Reactions P. Lall1, P. Hemmers2,3, J. Santilli2, K. Harper4; 1Bridgeport Hospital, Bridgeport, CT, 2Allergy Associates of Fairfield County, Bridgeport, CT, 3Allergy Center of Connecticut, Norwalk, CT, 4Cardiology Physicians, St.Vincent’s Hospital, Bridgeport, CT. 755 Different Patterns Of IgE Recognition To Amoxicillin In Patients With Immediate Hypersensitivity Reactions A. Ariza1, C. Mayorga1, I. Doña2, F. Gomez2, E. Perez-Inestrosa3, M. I. Montañez3, J. L. Rodriguez-Bada1, M. A. Guerrero2, M. Blanca2, M. J. Torres2; 1Research Laboratory F-IMABIS, Málaga, SPAIN, 2Allergy Service, Carlos Haya Hospital, Málaga, SPAIN, 3Organic Chemistry Department, Chemistry University, Málaga, SPAIN. 756 Desensitization to Temozolomide H. Mhanna, A. Jiménez Blanco, M. Valdez Tejeda, K. Jukic Beteta, M. Sánchez González, C. Fernandez Rodriguez, R. Vives Conesa; Hospital 12 de Octubre, Madrid, SPAIN. 757 Amoxicillin And Tlr Agonists Increase The Maturation Of Dendritic Cells From Patients With Non-immediate Allergy To Betalactams S. Lopez1, M. J. Torres2, M. J. Sanchez3, E. Gomez3, A. B. Blazquez3, C. Rondon2, M. A. Guerrero2, M. Blanca2, C. Mayorga3; 1Fundacion IMABIS, Málaga, SPAIN, 2Carlos Haya Hospital, Málaga, SPAIN, 3Fundacion IMABIS-Carlos Haya Hospital, Málaga, SPAIN. 758 Skin And Drug Provocation Tests In The Diagnosis Of NonImmediate Hypersensitivity Reactions To Iodinated Contrast Media M. J. Torres1, F. Gomez1, A. Rosado2, I. Doña1, N. BlancaLopez3, M. D. Cañamero1, L. Melendez4, G. Canto3, M. Blanca1; 1Carlos Haya Hospital, Málaga, SPAIN, 2Alcorcon Hospital, Madrid, SPAIN, 3Infanta Leonor Hospital, Madrid, SPAIN, 4Fundacion IMABIS-Carlos Haya Hospital, Málaga, SPAIN. 759 Skin Test And Specific IgE Predictive Value On The Chlorhexidine Allergy G. Senna1, P. Bonadonna1, B. Caruso2, C. Cocco2, A. Dama1, M. Conte1, G. Passalacqua3, C. Lombardo1; 1Allergy Unit Verona General Hospital, Verona, ITALY, 2Laboratory of Clinical Chemistry and Haematology Verona General Hospital, Verona, ITALY, 3Allergy and Respiratory Diseases, DIMI, University of Genoa, Genoa, ITALY. 760 The Importance of Vancomycin in Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome K. G. Blumenthal, S. Patil, M. Ling, A. Long; Massachusetts General Hospital, Boston, MA. 762 Immediate Hypersensitivity Reaction and Successful Rapid Desensitization to Rituximab Followed by Serum Sickness in a 4 Year Old E. Romanos-Sirakis, B. A. Feigenbaum; NYU School of Medicine, New York, NY.

Abstracts  AB311

Rhinitis: Treatment 4208 Session Time: Monday, March 21, 2011 9:45:00 AM - 10:45:00 AM

763 Intranasal Toll-like Receptor 8 Agonist (VTX-1463) Significantly Improves Symptoms of Allergic Rhinitis in a Randomized, Placebo-Controlled Trial F. Horak 1, P. Zieglmayer 1, R. Zieglmayer 1, P. Lemell 1, M. Newkirk2, K. Manjarrez2, T. D. Randall2, R. Hershberg2; 1 Vienna Challenge Chamber, Vienna, AUSTRIA, 2 VentiRx Pharmaceuticals, Seattle, WA. 764 Onset of Action of MP29-02 in the Treatment of Seasonal Allergic Rhinitis J. A. Bernstein1, U. Munzel2, W. Wheeler3, H. Sacks3; 1University of Cincinnati College of Medicine, Cincinnati, OH, 2MEDA Pharma GmbH & Co, Homburg, GERMANY, 3Meda Pharmaceuticals, Inc., Somerset, NJ. 765 MP29-02 in the Treatment of Nasal Symptoms of Seasonal Allergic Rhinitis W. Carr1, S. R. Shah2, W. Wheeler3, H. Sacks3; 1Allergy & Asthma Associates, Mission Viejo, CA, 2PA Allergy & Asthma Consultants, Collegeville, PA, 3Meda Pharmaceuticals, Inc., Somerset, NJ. 766 Dietary Antioxidant May Affect the Development of Allergic Rhinitis, but Not in Atopy, in Korean School-children J. Seo1, J. Kwon1, B. Kim2, J. Yu1, H. Kim3, S. Lee4, W. Kim5, K. Kim6, S. Kwon7, S. Oh7, Y. Shin8, S. Hong1; 1Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, Seoul, KOREA, REPUBLIC OF, 2Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, KOREA, REPUBLIC OF, 3Pediatric Asthma & Allergy Center, Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, KOREA, REPUBLIC OF, 4Department of Pediatrics, Hallym University Sacred Heart Hospital, Anyang, KOREA, REPUBLIC OF, 5Department of Pediatrics, Inje University Seoul Paik Hospital, Seoul, KOREA, REPUBLIC OF, 6Department of Pediatrics, Severance Hospital, Seoul, KOREA, REPUBLIC OF, 7Department of Food and Nutrition, College of Human Ecology, Kyung Hee University, Seoul, KOREA, REPUBLIC OF, 8Department of Psychiatry, Severance Hospital, Seoul, KOREA, REPUBLIC OF. 767 BDP HFA Nasal Aerosol Effectively Improves Nasal Symptom Relief and Health-Related Quality of Life (QOL) in Subjects with Seasonal Allergic Rhinitis (SAR) J. van Bavel1, F. C. Hampel2, P. H. Ratner3, A. Melchior4, S. A. Dunbar4, S. K. Tantry4, P. M. Dorinsky4; 1Allergy and Asthma Associates, Austin, TX, 2Central Texas Allergy and Asthma, New Braunfels, TX, 3Sylvana Research Associates, San Antonio, TX, 4Teva Branded Pharmaceutical Products R&D, Inc., Horsham, PA. 768 Topical Intranasal Hexabrix Is Effective In Reducing the Acute Response to Nasal Challenge with Allergen (NAC) F. M. Baroody1, S. Vishwanath1, M. Chaaban1, M. deTineo1, K. H. Lasser2, E. Lasser3, R. M. Naclerio1; 1University of Chicago, Chicago, IL, 2Kaiser Permanente, San Diego, CA, 3University of California San Diego, San Diego, CA. 769 Intranasal Corticosteroid Theraphy in Idiopathic Rhinitis: a Comparative Study with Allergic Rhinitis A. Baccioglu Kavut, F. Kalpaklioglu; Kirikkale University Faculty of Medicine, Department of Allergic Diseases, Kirikkale, TURKEY.

MONDAY

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB312 Abstracts

MONDAY

770 Results of the Rhinoconjunctivitis Related Quality of Life Questionnaire Administered to Subjects with Seasonal Allergic Rhinitis Following Treatment with Ciclesonide Hydrofluoroalkane Nasal Aerosol C. Andrews1, P. Ratner2, B. Martin2, W. Howland3, H. Huang4, S. Y. Desai4, F. Bode4; 1Diagnostics Research Group, San Antonio, TX, 2Sylvana Research Associates, San Antonio, TX, 3Southwest Allergy and Asthma Center, San Antonio, TX, 4Sepracor Inc, Marlborough, MA. 771 An Analysis of Quality of Life in Subjects 18-64 Years of Age with Seasonal Allergic Rhinitis Following Treatment with Ciclesonide Aqueous Nasal Spray D. Mohar1, S. Y. Desai2, H. Huang2, J. Karafilidis2; 1Kerrville Research Associates, Kerrville, TX, 2Sepracor Inc, Marlborough, MA. 772 Oxymetazoline (OXY) Adds To The Effectiveness Of Fluticasone Furoate Nasal Spray (FFNS) In The Treatment Of Perennial Allergic Rhinitis (PAR) M. deTineo, F. M. Baroody, D. Brown, L. Gavanescu, R. M. Naclerio; University of Chicago, Chicago, IL. 773 A Study Evaluating the Efficacy and Safety of Ciclesonide Hydrofluoroalkane Nasal Aerosol in the Relief of Nasal Symptoms of Seasonal Allergic Rhinitis W. Howland1, P. Ratner2, B. Martin3, C. Andrews4, H. Huang5, S. Y. Desai5, F. Bode5; 1 Sirius Clinical Research, Austin, TX, 2 Sylvana Research Associates, San Antonio, TX, 3Southwest Allergy and Asthma Center, San Antonio, TX, 4Diagnostics Research Group, San Antonio, TX, 5Sepracor Inc, Marlborough, MA. 774 Quality Of Life In Patients Taking Guaifenesin And Pseudoephedrine In An Extended-release Bi-layer Tablet As First-line Symptomatic Therapy For Acute Upper Respiratory Tract Infections (URI) H. G. Mariano, Jr1, G. Solomon2, E. C. Steward2, H. H. Albrecht2; 1 Research Center of Fresno, Inc., Fresno, CA, 2 Clinical Development, Reckitt Benckiser (North America), Inc., Parsippany, NJ. 775 Regular Use of Cetirizine Demonstrates Consistent Relief from Symptoms of Seasonal Allergic Rhinitis in Children E. R. Urdaneta1, P. A. Przygoda1, C. L. Lin1, M. K. Patel1, K. B. Franklin1, M. Wu2; 1McNeil Consumer Healthcare, Fort Washington, PA, 2Johnson & Johnson Consumer Products Worldwide, Morris Plains, NJ. 776 Ectoin®, a Novel, Non-Drug, Extremophile-Based Device, Relieves Allergic Rhinoconjunctivitis Symptoms in Patients in an Environmental Exposure Chamber Model A. Salapatek1, M. Bates1, A. Bilstein2, D. Patel1; 1Cetero Research, Mississauga, ON, CANADA, 2bitop AG, Stockumer, GERMANY. 777 Management of Allergic Rhinitis patients with Nasal Steroids and NeilMed® Sinus Rinse™ System with Isotonic Saline: A Prospective Pilot Study S. A. Nguyen, J. Condrey, R. J. Schlosser; Medical University of South Carolina, charleston, SC. 778 Cellulose Powder for the Treatment of Persistent Allergic Rhinitis in Children and Adolescents: a Pilot Study G. F. Wandalsen, A. I. Mendes, D. Solé; Federal University of São Paulo, São Paulo - SP, BRAZIL.

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

Immunotherapy/Immunomodulation Mechanisms 4209 Session Time: Monday, March 21, 2011 9:45:00 AM - 10:45:00 AM

779 Allergen-specific IgE and IgG4 Measured by Microarray Technique (ISAC) in Patients With Clinical Improvement on Sublingual Immunotherapy (SLIT) J. C. Thompson, M. S. Morris, D. S. Theodoropoulos; Allergy Associates of La Crosse, Onalaska, WI. 780 Serum CTLA-4 and IL-10 in Hymenoptera Venom Immunotherapy. The Immunological Equivalence of Different Induction Protocols A. Riccio1, D. Saverino2, G. Pesce2, A. Rogkakou1, M. Severino3, P. Bonadonna 4, E. Ridolo 5, M. Mauro 6, M. Bagnasco 2, G. Canonica2, G. Passalacqua2; 1Allergy and Respiratory Diseases, DIMI, University of Genoa, Genova, ITALY, 2Medical and Radiomethabolic Therapy, University of Genoa, Genova, ITALY, 3Allergy Unit, Ospedale San Giovanni di Dio, Florence, Florence, ITALY, 4Allergy Service, Verona General Hospital, Verona, Verona, ITALY, 5Experimental and internal Medicine, University of Parma, Parma, ITALY, 6Allergy Unit Como Hospital, Como, ITALY. 781 Basophil Sensitivity Decreases During the Updosing of SCIT in Subjects Allergic to Grass Pollen J. M. Schmid, R. Dahl, H. J. Hoffmann; Aarhus University Hospital, Aarhus, DENMARK. 782 Impact of Allergen Specific Immunotherapy and Bacteriaderived Immunomodulator on Subpopulations of Lymphocytes and Cytokine Synthesis in Patients with Respiratory Allergies A. B. Turemuratov1, S. K. Turemuratova1, A. A. Shortanbaev1, Z. A. Satybaldieva1, L. M. DuBuske2; 1Kazakh National Medical University, Almaty, KAZAKHSTAN, 2Immunology Research Institute of New England, Gardner, MA. 783 Novel Assays For The Assessment Of Fc-Dependent Functional Activities Of IGIV C. Hermann, J. Ilas, D. Fetahagic, J. Abadir, W. Teschner, H. P. Schwarz, B. M. Reipert; Baxter Bioscience, Vienna, AUSTRIA. 784 Follow Up of anti-IgE Therapy Using Peripheral Blood CD4+ Adenosine Triphosphate Activity A. Franco1, V. Matheu2, Y. Barrios1, J. Iglesias2, I. SanchezMachin2; 1Immunology Section. Hospital Universitario de Canarias, Santa Cruz de Tenerife, SPAIN, 2Allergy Department. Hospital Universitario Na Señora de Candelaria, Santa Cruz de Tenerife, SPAIN.

Eosinophils and Basophils 4210 Session Time: Monday, March 21, 2011 9:45:00 AM - 10:45:00 AM

785 Characterization of the Synthesis of the Eosinophil Siglec-F Glycan Ligand by Mouse Airway Epithelial Cells T. Kiwamoto, M. E. Brummet, H. J. Na, S. A. Hudson, B. S. Bochner; Johns Hopkins University, Baltimore, MD.

786 Eosinophils Suppress Epithelial Cell Interferon Expression P. S. Fichtinger1, J. T. Kelly1, J. E. Gern1, N. N. Jarjour1, S. K. Mathur1,2; 1University of Wisconsin, Madison, WI, 2Wm. S. Middleton VA Hospital, Madison, WI. 787 Eosinophil Extracellular DNA Traps In Skin Diseases D. Simon1, S. Hoesli2, N. Roth1, S. Staedler1, S. Yousefi2, H. U. Simon2; 1Dept. of Dermatology, Bern University Hospital, University of Bern, Bern, SWITZERLAND, 2Institute of Pharmacology, University of Bern, Bern, SWITZERLAND. 788 Exposure to Agents That Alter the Membrane Cholesterol Content of Human Eosinophils is Associated with the Modulation of MAP Kinase Signaling Pathways Critical for Eosinophil Activation M. E. Burnham, M. E. Bates, P. J. Bertics; University of Wisconsin School of Medicine and Public Health, Madison, WI. 789 Expression of TLR2, TLR4 and RAGE Receptors In Human Peripheral Blood Eosinophils Stimulated With Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) C. Straub, K. Pazdrak, A. Kurosky; The University of Texas Medical Brnach, Galveston, TX. 790 Inhibition of Notch Signaling Delays GM-CSF Induced ERK Pathway Activation in Human Eosinophils J. J. Xenakis, A. L. Radke, K. M. Young, R. C. N. Melo, L. A. Spencer; Beth Israel Deaconess Medical Center, Boston, MA. 791 Staphylococcus Aureus Directly Induces Effector Functions Of Eosinophils In Vitro K. Hosoki, M. Nagao, H. Tanida, Y. Hiraguchi, R. Tokuda, T. Fujisawa; Mie National Hospital, Tsu, JAPAN. 792 Proton Channel HVCN1 Is Involved In Reactive Oxygen Species Production By Eosinophils X. Zhu, J. F. Fadare, N. Zimmermann; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. 793 Membrane Expression of CLC3 in Human Blood Eosinophils R. Gaurav, T. O. Makinde, D. K. Agrawal; Center for Clinical and Translational Sciences, Creighton University School of Medicine, Omaha, NE. 794 The Interleukin 2 and 4-Inducible Protein Phosphatase 5 (PP5) Abrogates Phosphorylation of Glucocorticoid Receptor and Induction of Dual Specificity Phosphatase 1 (DUSP1) in Eosinophils K. Pazdrak, C. Straub, L. Richmond, K. Soman, A. Kurosky; Univ. of TX Medical Branch, Galveston, TX. 795 The Role of Eosinophil Activation in Preterm Infants with Bronchopulmonary Dysplasia S. Choi, Y. Rha; Kyunghee University School of Medicine, Seoul, KOREA, REPUBLIC OF. 796 Resistance To Eosinophil Reduction In Local Response By vitamin D3 In Elder Mice V. Matheu1, M. Arnau2, Y. Barrios3; 1Hospital Universitario NS Candelaria, S/C Tenerife, SPAIN, 2Universidad de La Laguna, La Laguna, SPAIN, 3Hospital Universitario de Canarias, La Laguna, SPAIN. 797 Diagnostic Utility Of Serum Biomarkers In Distinguishing Between Churg-strauss Syndrome And Hypereosinophilic Syndrome P. Khoury, A. Klion; National Institutes of Health, Bethesda, MD. 798 Mortality in Hypereosinophilic Syndrome: Ten Years of Experience at Mayo Clinic J. Podjasek, J. Butterfield; Mayo Clinic, Rochester, MN.

799 The Association between Nasal Eosinophils and Sensitization to Aeroallergens in Allergic March M. Shinohara1, H. Saito2, K. Matsumoto2; 1Department of Allergy and Pediatrics, Shimoshizu National Hospital, Shikawatari, JAPAN, 2National Research Institute for Child Health and Development, Allergy and Immunology Deparement, Setagaya-ku, JAPAN. 800 A Prospective Follow-Up Study in Patients with Eosinophilic Bronchitis L. Arochena1, E. Aguado1, M. del Potro1, M. Fernández-Nieto1,2, J. Sastre1,2; 1 Fundación Jiménez Díaz, Madrid, SPAIN, 2 CIBER de Enfermedades Respiratorias (CIBERES), Madrid, SPAIN. 801 Effect of Maternal Allergic Sensitization and Smoking during Pregnancy on Eosinophil- Basophil Lineage Commitment P. Reece1, A. Thanendran1, M. Tulic2, S. Prescott2, R. Sehmi1, J. Denburg1; 1McMaster, Hamilton, ON, CANADA, 2University Western Australia, Perth, AUSTRALIA. 802 Differential Expression of Pre-formed Cytokines in Human Basophils and Eosinophils E. K. Clarke, J. J. Xenakis, L. A. Spencer; Beth Israel Deaconess Medical Center, Brookline, MA. 803 Human Basophils can Function as Antigen Presenting Cells for Established T-Cell Lines. G. Lund, G. Grauert, G. K. Koed, J. Skovsgaard, K. Lund, P. A. Würtzen; Dpt. of Experimental Immunology, ALK-Abello A/S, Hoersholm, DENMARK. 804 Preparation of a New Basophil-Specific Monoclonal Antibody: Insights into the Properties of Basogranulin A. Fawzy1,2, B. L. Nicholas1, L. C. Lau1, B. F. Gibbs3, A. F. Walls1; 1University of Southampton, Southampton, UNITED KINGDOM, 2National Research Center of Egypt, Cairo, EGYPT, 3University of Kent, Chatham Maritime, UNITED KINGDOM. 805 The Role of Advanced Glycation Endproducts (AGEs) on Basophil Functions M. Suzukawa, M. Yamaguchi, K. Han, T. Toda, H. Nagase, K. Ohta; Teikyo University, Itabashi-Ku, JAPAN. 806 Gene Expression Profiles in Human Basophils after Exposure to Immobilized Human IgG K. Matsumoto1, N. Aida1, N. Hashimoto1, T. Nakajima1,2, H. Saito1; 1National Research Institute for Child Health and Development, Tokyo, JAPAN, 2Yokohama College of Pharmacy, Kanagawa, JAPAN.

IgE 4211 Session Time: Monday, March 21, 2011 9:45:00 AM - 10:45:00 AM

807 IgE and IgG4-Binding Diversity Changes Over Time in MilkAllergic Children Who Tolerate Extensively Heated-Milk Products G. Gimenez, J. Wang, J. Lin, L. Bardina, H. A. Sampson; Mount Sinai School of Medicine, New York, NY. 808 Relationships Among Total IgE and Rhinovirus-induced Interferons in Peripheral Blood D. J. Montville1, A. S. Pratt1, V. P. Rajamanickam1, N. C. Levinsky1, C. J. Tisler1, R. E. Gangnon1, M. A. Gill2, D. J. Jackson1; 1University of Wisconsin, Madison, WI, 2University of Texas Southwestern, Dallas, TX. 809 An Immunoassay to Measure Free IgE in Individuals Receiving Anti-IgE Therapy S. Roberts, M. Collwell, H. Wells, J. Myers, S. Oltremari, P. Walters, C. Brockus, M. Ling, J. F. Halsey, M. Altrich; Viracor-IBT Laboratories, Lenexa, KS.

MONDAY

Abstracts  AB313

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB314 Abstracts

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

MONDAY

810 Green Tea Extract (GTE) Catechin, Epigallocatechin Gallate (EGCG), Suppresses Ige Responses In Vitro S. J. Wu1, J. I. Silverberg2, H. G. Durkin3, R. Joks3, T. A. SmithNorowitz3; 1LICH/SUNY Downstate Medical Center, Center for Allergy and Asthma Research, Brooklyn, NY, 2St Luke’s-Roosevelt Hospital / Beth Israel Medical Centers, New York, NY, 3SUNY Downstate Medical Center, Center for Allergy and Asthma Research, Brooklyn, NY. 811 Obesity is Associated with Elevated IgE levels in an Atopic Population S. Fitzpatrick; SUNY Downstate/Long Island College Hospital, Brooklyn, NY. 812 Variability of Total and Free IgE and IgE Receptor Expression in Allergic Subjects in and out of an Allergen Season M. Carlsson1, S. Larsson-Faria1, K. Behrens1, C. Lindqvist1, K. Buttler1, S. Keeler2, A. Sjölander3, L. Thorell3, P. Eriksson1; 1AstraZeneca, Lund, SWEDEN, 2AstraZeneca, Loughborough, UNITED KINGDOM, 3Phadia AB, Uppsala, SWEDEN. 813 Persistence Of IgE Anti-influenza Virus Antibodies In Pediatric And Adult Serum Post Vaccination With Influenza Virus Vaccine D. Wong1, M. Kusonruksa1, K. B. Norowitz1, R. Joks1, H. G. Durkin1, M. H. Bluth2, T. A. Smith-Norowitz1; 1State University of New York Downstate Medical Center, Center for Allergy and Asthma Research, Brooklyn, NY, 2Wayne State University School of Medicine, Department of Pathology, Detroit, MI. 814 The Effects of Omalizumab on the Late-Phase Response to Nasal Allergen Challenge M. O. Paterniti, L. M. Breslin, P. M. Sterba, M. E. Brummet, Y. Park, D. W. MacGlashan, Jr., B. S. Bochner, S. S. Saini; Johns Hopkins University School of Medicine, Baltimore, MD. 815 Subjects With Extremely Elevated IgE Levels: A Descriptive Study R. M. Elias, A. Y. Joshi, M. A. Park, J. B. Hagan; Mayo Clinic, Rochester, MN.

Oral Abstract Session Asthma Genetics 4601 Session Time: Monday, March 21, 2011 2:00:00 PM - 3:15:00 PM

816 Genetic Variation in the Promoter Region of the TumorNecrosis Factor Alpha (TNF-a) Gene is Associated with Asthma B. K. Graham 1,2, B. L. Jones 1,2, L. J. Rosenwasser1,2, A. K. Riffel1,2, C. A. Vyhlidal1,2; 1Children’s Mercy Hospitals and Clinics, Kansas City, MO, 2University of Missouri Kansas City School of Medicine, Kansas City, MO. 817 The ORMDL3 Locus And Asthma In Four Populations Of African Ancestry R. A. Mathias1, N. Rafaels1, V. Mantese1, T. Murray1, C. Vergara1, L. Gao1, M. Araujo2, L. Caraballo3, J. M. Knight-Madden4, G. Dunston5, I. Ruczinski1, T. Beaty1, K. C. Barnes1, .. GRAAD1; 1Johns Hopkins University, Baltimore, MD 21224, MD, 2Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Bahia, BRAZIL, 3 University of Cartagena, Cartagena, COLOMBIA, 4University of the West Indies, Jamaica, JAMAICA, 5Howard University, Washington, DC.

818 Comparison Of Montelukast Versus Salmeterol In Children With Asthma Carrying At-Risk b 2adrenergic Receptor Polymorphism: A Genotype-Stratified Randomised Controlled Trial K. Basu1,2, H. P. Donald2, B. J. Lipworth2, R. Tavendale2, D. F. Macgregor2, S. A. Ogston2, C. N. A. Palmer2, S. Mukhopadhyay1,2; 1Royal Alexandra Children’s Hospital, Brighton, UNITED KINGDOM, 2Ninewells Hospital and Medical School, University of Dundee, Dundee, UNITED KINGDOM. 819 Replication of a Genetic Association between Polymorphisms in KCNMA1 and Asthma in Six Populations of African Ancestry V. J. Mantese1, N. Rafaels1, T. Murray1, C. Vergara1, L. Gao1, M. I. Araujo2, L. Caraballo3, J. M. Knight-Madden4, J. Ford1, G. Dunston5, I. Ruczinski1, T. H. Beaty1, K. C. Barnes1, R. A. Mathias1; 1 Johns Hopkins University, Baltimore, MD, 2 Hospital Universitario Professor Edgard Santos, Salvador, Bahia, BRAZIL, 3University of Cartagena, Cartagena, COLOMBIA, 4University of the West Indies, Mona, JAMAICA, 5Howard University, Washington, DC. 820 Buccal Mucosal Sampling is a Reliable Method to Determine Differences in Gene Expression Patterns between Subjects with Asthma Compared to Healthy Controls B. L. Jones1,2, L. J. Rosenwasser1,2, A. K. Riffel1,2, B. K. Graham1,2, C. A. Vyhlidal1,2; 1Children’s Mercy Hospital and Clinics, Kansas City, MO, 2University of Missouri Kansas City School of Medicine, Kansas City, MO.

IgG Replacement Therapy 4602 Session Time: Monday, March 21, 2011 2:00:00 PM - 3:15:00 PM

821 Pharmacokinetics (PK) of Human Immunoglobulin 10% Administered Subcutaneously Alone or Following Recombinant Human Hyaluronidase (rHuPH20) in Primary Immunodeficiency Disease (PIDD) Patients A. Rubinstein1, R. L. Wasserman2, I. Melamed3, M. Stein4, B. McCoy5, W. Engl5, H. Leibl5, D. Gelmont6, R. I. Schiff6, W. J. Grossman6; 1Albert Einstein College of Medicine and Montefiore Hospital, Bronx, NY, 2DallasAllergyImmunology, Dallas, TX, 3IMMUNOe, Centennial, CO, 4Allergy Associates of the Palm Beaches, North Palm Beach, FL, 5Baxter BioScience, Vienna, AUSTRIA, 6Baxter BioScience, Westlake Village, CA. 822 Subcutaneous Immunoglobulin Replacement Therapy in Infants and Children with Primary Immunodeficiencies J. A. Church1, V. Howard2, J. W. Sleasman3, M. Borte4, M. Berger5; 1Childrens Hospital Los Angeles, Los Angeles, CA, 2St. Jude Children’s Research Hospital, Memphis, TN, 3University of South Florida, St. Petersburg, FL, 4Municipal Hospital “St. Georg” Leipzig, Academic Teaching Hospital of the University of Leipzig, Leipzig, GERMANY, 5CSL Behring LLC, King of Prussia, PA. 823 Subcutaneous Immunoglobulin Replacement Therapy for Primary Immunodeficiency: High-Dose versus Low-Dose Treatment using Hizentra® J. Hagan1, R. L. Wasserman2, O. Zenker3, M. Borte4; 1Mayo, Rochester, MN, 2DallasAllergyImmunology and Medical City Children’s Hospital, Dallas, TX, 3CSL Behring GmbH, Marburg, GERMANY, 4Municipal Hospital “St. Georg” Leipzig, Academic Teaching Hospital of the University of Leipzig, Leipzig, GERMANY. 824 Comparison of American and European practices in Primary Immunodeficiency H. S. Hernandez-Trujillo 1, H. Chapel 2, J. M. Boyle 3, C. Scalchunes4, M. L. Boyle4, J. S. Orange1;

1Children’s Hospital of Philadelphia, Philadelphia, PA, 2University of Oxford, Oxford, UNITED KINGDOM, 3Abt SRBI, Silver Spring, MD, 4Immune Deficiency Foundation, Towson, MD. 825 Pharmacokinetic Factors in IgG Supplementation by the Intravenous and Subcutaneous Routes S. Jolles1, M. Berger2, M. Bexon3, O. Zenker4, J. Sawyer5; 1University Hospital of Wales, Cardiff, UNITED KINGDOM, 2CSL Behring LLC, King of Prussia, PA, 3CSL Behring AG, Berne, SWITZERLAND, 4CSL Behring GmbH, Marburg, GERMANY, 5Prism Ideas Ltd, Nantwich, UNITED KINGDOM.

Air Pollutants from Traffic and Tobacco: Effects on Lung Health 4603 Session Time: Monday, March 21, 2011 2:00:00 PM - 3:15:00 PM

826 The Association between Timing of Home Environmental Tobacco Smoke Exposure during Childhood and Age of Asthma Development E. Simons1, D. Stieb2, T. To1, R. Moineddin3, S. Dell4; 1The Hospital for Sick Children, Child Health Evaluative Sciences, Toronto, ON, CANADA, 2Health Canada, Ottawa, ON, CANADA, 3The University of Toronto, Department of Family and Community Medicine, Toronto, ON, CANADA, 4The Hospital for Sick Children, Respiratory Medicine and Child Health Evaluative Sciences, Toronto, ON, CANADA. 827 Synergistic Effect between Air Pollution and Past Bronchiolitis on the Development of Asthma in Schoolchildren B. Kim1, J. Kwon2, J. Seo2, H. Kim3, S. Lee4, J. Yu2, S. Hong2; 1Inje University Haeundae Paik Hospital, Busan, KOREA, REPUBLIC OF, 2Asan Medical Center, University of Ulsan College of Medicine, Seoul, KOREA, REPUBLIC OF, 3Inje University Sanggye Paik Hospital, Seoul, KOREA, REPUBLIC OF, 4Hallym University Medical Center, Anyang, KOREA, REPUBLIC OF. 828 The Effect of Secondhand Smoke Exposure on Bronchiolitis Severity in Infants With and Without Familial Atopy M. P. Lemke, T. V. Hartert, T. Gebretsadik, P. Minton, K. Woodward, Z. Liu, K. N. Carroll; Vanderbilt University Medical Center, Nashville, TN. 829 Cigarette Smoke Extract Exposure Up-regulates the Expression of RhoA Pathway in Murine Airways A. I. Berro, S. Jia, T. B. Casale; Creighton University School of Medicine, Omaha, NE. 830 Diesel Exhaust (DE)-Associated Increase In Airway Reactivity Is Mitigated By Anti-Oxidant Supplementation In Asthmatics C. Carlsten1, M. Pui1, M. Macnutt1, A. DyBuncio1, J. Lay2, N. Alexis2; 1University of British Columbia, Vancouver, BC, CANADA, 2University of North Carolina, Chapel Hill, NC.

Eosinophil Gastrointestinal Disease 4604 Session Time: Monday, March 21, 2011 2:00:00 PM - 3:15:00 PM

831 Global Gene Expression Profile Analysis in Eosinophilic Gastritis Identifies CDH26 J. M. Caldwell, M. H. Collins, C. Blanchard, E. M. Stucke, P. E. Putnam, J. P. Franciosi, J. P. Abonia, M. E. Rothenberg; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.

Abstracts  AB315

832 Follow-up Of A Single-centre Cohort Of Patients With Eosinophilic Esophagitis: Clinical Features And Prognosis I. N. Fung1, M. Dye2, J. M. Spergel1; 1Children’s Hospital of Philadelphia, Philadelphia, PA, 2College of New Jersey, Ewing, NJ. 833 Milk Protein-specific Cytokine Secretion Profiles In Infant Patients With Fpies And Proctocolitis H. Morita1, I. Nomura2, K. Orihara1, A. Matsuda1, H. Saito1, K. Matsumoto1; 1National Research Institute for Child Health and Development, Tokyo, JAPAN, 2National Medical Center for Children and Mothers, Tokyo, JAPAN. 834 Dysregulation of the Desmosomal Cadherin Desmoglein-1 in Eosinophilic Esophagitis J. D. Sherrill1, E. M. Stucke1, M. S. Costello1, V. L. Fabry1, M. H. Collins1, P. E. Putnam1, J. P. Franciosi1, J. P. Abonia1, L. J. Martin1, P. M. A. Sleiman2, J. M. Spergel2, H. Hakonarson2, M. E. Rothenberg1; 1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2The Children’s Hospital of Philadelphia, Philadelphia, PA. 835 Sex of Parent is Associated with Familial Risk of Eosinophilic Esophagitis E. S. Alexander1,2, L. J. Martin3,1, J. P. Abonia2,1, H. Foote2, M. D. Eby2, M. E. Rothenberg2,1; 1University of Cincinnati College of Medicine, Cincinnati, OH, 2Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 3Division of Biostatistics and Epidemiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.

Quality of Life and Issues in Clinical Research 4605 Session Time: Monday, March 21, 2011 2:00:00 PM - 3:15:00 PM

836 The Nasal Allergy Survey Assessing Limitations (NASL) 2010 Survey: Allergic Rhinitis Is Associated with Substantial Sleep Disturbances W. Storms1, E. Meltzer2, J. Derebery3, G. Ortiz4, L. Fromer5; 1William Storms Allergy Clinic, Colorado Springs, CO, 2Allergy & Asthma Medical Group and Research Center, San Diego, CA, 3University of Southern California, Los Angeles, CA, 4Pediatric Pulmonary Services, El Paso, TX, 5Leonard Fromer, MD Consulting, Los Angeles, CA. 837 Subject Recruitment for Clinical Research D. Schroer, D. L. McNeil; Optimed Research, Columbus, OH. 838 Nasal Allergy Survey Assessing Limitations (NASL) 2010 Survey: Allergic Rhinitis Continues to Impact Patient Quality of Life G. Gross1, R. Katial2, J. Hadley3, B. Marple4, S. Ryan5, S. Stoloff6; 1Dallas Allergy & Asthma Center, Dallas, TX, 2National Jewish Health, University of Colorado, Denver, CO, 3University of Rochester Medical Center, Rochester, NY, 4University of Texas Southwestern Medical Center, Dallas, TX, 5Take Care Health Systems, Conshohocken, PA, 6University of Nevada, Carson City, NV. 839 Daily Symptom Diaries Versus Retrospective Symptom Questionnaires in Clinical Trials: Is This Burden Worth The Effort? A. Y. Okupa1, C. A. Sorkness1, D. T. Mauger2, D. J. Jackson1, R. F. Lemanske1; 1University of Wisconsin, Madison, WI, 2Penn State University College of Medicine, Hershey, PA.

MONDAY

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB316 Abstracts

840 Adolescent Attitudes Towards Asthma in an Overweight Innercity Population K. K. Shanovich, I. A. Awoyinka, M. Chih, F. McTavish, C. Sorkness, D. Gustafson; University of Wisconsin - Madison, Madison, WI.

Systemic Immunotherapy 4606 Session Time: Monday, March 21, 2011 2:00:00 PM - 3:15:00 PM

841 Subcutaneous Immunotherapy and Pharmacotherapy in Seasonal Allergic Rhinitis: A Comparison based on MetaAnalyses P. M. Matricardi1, P. Kuna2, U. Wahn1, A. Narkus3; 1Department of Paediatric Pneumology and Immunology, Charité Medical Center, Berlin, GERMANY, 2Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Lodz, POLAND, 3Allergopharma Joachim Ganzer KG, Reinbeck, GERMANY. 842 AAAAI/ACAAI Surveillance Study of Subcutaneous Immunotherapy (SCIT) injections (Year 2): Time of Onset and Treatment of Systemic Reactions (SRs) T. Epstein1, D. I. Bernstein1, K. Murphy2, G. M. Liss3; 1University of Cincinnati College of Medicine, Cincinnati, OH, 2Bernstein Clinical Research Center, Cincinnati, OH, 3University of Toronto, Toronto, ON, CANADA. 843 Development and Preliminary Clinical Evaluation of a Peptide Immunotherapy Vaccine for Cat Allergy M. Larché1, H. Lee2, J. Kleine-Tebbe3, R. P. Hafner4, P. Laidler4, D. Healey5, C. Buhot6, A. Verhoef5, B. Maillère6, A. B. Kay5, M. Worm2; 1McMaster University/St. Joseph’s Healthcare, Hamilton, ON, CANADA, 2Charité Universitätsmedizin, Berlin, GERMANY, 3 Allergy & Asthma Center Westend, Berlin, GERMANY, 4Circassia Limited, Oxford, UNITED KINGDOM, 5Imperial College, London, UNITED KINGDOM, 6Commissariat à l’Energie Atomique, Saclay, FRANCE. 844 The Crucial Role Of The Stratum Corneum Superficial Layers During Peanut Epicutaneous Immunotherapy (epit) L. Mondoulet 1, V. Dioszeghy 1, M. Ligouis 1, V. Dhelft 1, E. Puteaux1, C. Dupont2, P. Benhamou1; 1DBV Technologies, PARIS, FRANCE, 2Hopital Saint Vincent de Paul - Université Paris Descartes, PARIS, FRANCE. 845 Subcutaneous Immunotherapy (SCIT) Is Allergen-specific: A Double-blind Trial Of Mite Or Timothy Extract In Mite And Grass Dual Allergic Patients S. Dreborg1, T. Lee2, A. B. Kay3, S. R. Durham3; 1Department of Pediatrics, National Hospital, Oslo, NORWAY, 2King’s College London, London, UNITED KINGDOM, 3Imperial College, London, UNITED KINGDOM.

TUESDAY

Cytokines and Soluble Mediators in Allergic Disease 4607 Session Time: Monday, March 21, 2011 2:00:00 PM - 3:15:00 PM

846 Epigenetic Regulation Of The Il-13-induced Human Eotaxin-3 Gene By CBP Mediated Histone-3 Acetylation E. Lim, T. Lu, C. Blanchard, M. Rothenberg; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

847 Effects Of Neuropeptide Y On Monocyte-derived Dendritic Cell Function M. Pham, Z. SHAO, L. Lorence, R. Gaurav, D. K. Agrawal; Center for Clinical & Translational Science, Creighton University School of Medicine, OMAHA, NE. 848 Angiogenesis In Asthma: A Novel Potential Role For Il-25 W. Wang1, Q. Meng2, C. Fang2, V. Reay2, H. F. Wu2, Y. Q. Fan1, Z. Lv1, Y. Q. An1, Y. H. Wang3, Y. J. Liu3, T. H. Lee2, C. J. Corrigan2, S. Ying2; 1Capital Medical University, Beijing, CHINA, 2King’s College London, London, UNITED KINGDOM, 3M. D. Anderson Cancer Centre, Houston, TX. 849 Allergen-induced Expression Of Il-25 And Il-25 Receptor In Asthmatic Airways And In Allergen-induced Late Phase Cutaneous Responses In Atopic Subjects S. Ying1, W. Wang2, Q. Meng1, C. Fang1, Z. Lv2, Y. Q. An2, Y. H. Wang3, Y. J. Liu3, R. Caballero1, T. H. Lee1, C. J. Corrigan1; 1King’s College London, London, UNITED KINGDOM, 2Capital Medical University, Beijing, CHINA, 3M. D. Anderson Cancer Centre, Houston, TX. 850 MicroRNA-21 Deficiency Leads to an Attenuated Asthma Response in Mice T. X. Lu1, V. Fabry1, E. Lim1, E. T. Cole1, S. H. Orkin2, M. E. Rothenberg1; 1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Dana Farber Cancer Institute, Boston, MA.

Poster Session Diagnosis and Management of Asthma I 5201 Session Time: Tuesday, March 22, 2011 9:45:00 AM - 10:45:00 AM

851 Is Asthma in Athletes A New Asthma Phenotype? B. SASTRE; IIS- FUNDACIÓN JIMÉNEZ-DÍAZ, CIBERES, MADRID, SPAIN. 852 Exercise-Induced Bronchoconstriction in Children without Asthma S. Sommanus, K. Rakkhong, W. Kamchaisatian, C. Sasisakulporn, W. Teawsomboonkit, S. Vilaiyuk, S. Benjaponpitak; Ramathibodi hospital, Mahidol university, Bangkok, THAILAND. 853 Comparison of Bronchodilator Responsiveness After Methacholine-induced and AMP-induced Bronchoconstriciton in Asthmatic Children Y. Yoo, S. Bauer, J. Kim, K. La, D. Song, H. Kim, J. Choung; Korea University Anam Hospital, Seoul, KOREA, REPUBLIC OF. 854 Assessments of Initial Diagnostic Criteria and Chronic Treatment Plans for Asthma Patients in Saint-Petersburg, Russia over the Last Decade A. Emelyanov1, I. Tsukanova1, G. Sergeeva1, G. Fedoseev2, N. Lisitsyna2, L. Bakanina2, E. Nikitina2, L. M. DuBuske3; 1Department of Respiratory Disease, Postgraduate Medical Academy, Saint-Petersburg, RUSSIAN FEDERATION, 2Hospital Therapeutic Clinic, Pavlov Medical University, Saint-Petersburg, RUSSIAN FEDERATION, 3Immunology Research Institute of New England, Gardner, MA. 855 IgG and IgG4 Isotype Antibodies to Fel d 1 In Allergic and Non-allergic Students (n = 963): Relationship to Symptoms of Asthma T. A. E. Platts-Mills1, B. Lundback2, J. M. Roper1, M. Mori1, E. Ronmark2;

Abstracts  AB317

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Diagnosis and Management of Asthma II 5202 Session Time: Tuesday, March 22, 2011 9:45:00 AM - 10:45:00 AM

861 Bronchodilator Responsiveness to Formoterol (FM)-Containing Treatments Based on Measures of Pulmonary Function and Lung Volume in Patients with Chronic Obstructive Pulmonary Disease (COPD) D. P. Tashkin1, B. Celli2, S. I. Rennard3, J. McElhattan4, U. J. Martin4; 1David Geffen School of Medicine at UCLA, Los Angeles, CA, 2Harvard University, Boston, MA, 3University of Nebraska Medical Center, Omaha, NE, 4AstraZeneca LP, Wilmington, DE. 862 Clinical Characteristics of a Newly Described Airway Disease Presenting with Lymphocytic Bronchiolitis and Granulomas: Severe Adult Onset Asthma Misdiagnosed A. S. Larkin1, S. A. Yousem2, S. E. Wenzel1; 1University of Pittsburgh Asthma Institute at University of Pittsburgh Medical Center and the University of Pittsburgh School of Medicine, Pittsburgh, PA, 2Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA. 863 Association Between Responses to Inhaled Bronchodilator or Inhaled Bronchoconstrictor Challenge and Exhaled Breath Temperature assessed by the X-halo portable hand held device T. A. Popov1, T. Z. Kralimarkova1, T. Grigorova1, R. Mincheva1, G. Garcia2, A. Yanez3, M. Bergna4, V. D. Dimitrov1, L. M. DuBuske5; 1Clinic of Allergy and Asthma, Sofia, BULGARIA, 2Pneumology, CENASMA, La Plata, Buenos Aires, ARGENTINA, 3Pneumology, INAER, Buenos Aires, ARGENTINA, 4Pneumology, Hospital Antonio Cetrángolo, Vicente Lopez, Buenos Aires, ARGENTINA, 5Immunology Research Institute of New England, Gardner, MA. 864 Altered Composition Of Gut Microflora In Wheezing Infants From Cartagena, A Tropical City Of Colombia

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J. Zakzuk1, G. Solano-Aguilar2, J. Sanchez1, N. Acevedo1, A. Bornacelly1, H. Ets2, L. Caraballo1; 1Institute for Immunological Research, University of Cartagena, Cartagena, COLOMBIA, 2Diet Genomics and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service-USDA, Beltsville, MD. Are Asthmatics At Greater Risk For Stroke Than Nonasthmatics? C. Xu1, D. R. Sun2; 1VHQC, Glen Allen, VA, 2Virginia Commonwealth University, Richmond, VA. Clinical and Laboratory Features of Asthmatic Patients with Aspirin Exacerbated Respiratory Disease (AERD) R. C. Agondi, M. G. Roso, G. P. Lima, N. C. Portilho, D. B. Borges, J. Kalil, P. Giavina-Bianchi; University of São Paulo, São Paulo, BRAZIL. Ige-facilitated Binding Of Cockroach Allergen-ige Complexes To B Cells: An Assay To Monitor Efficacy During Immunotherapy? J. Nicholson, A. R. Ratnayake, M. Poon, A. Togias, S. Durham, M. Shamji; Imperial College London, South Kensington, UNITED KINGDOM. Clinical Pathway for Childhood Asthma in an Emergency Department: Comparison between Correct and Incorrect Application Group H. Kim1, Y. Chun1, J. Yoon2, J. Kim2, J. Lee2; 1 The Catholic University of Korea, Pucheon-si, KOREA, REPUBLIC OF, 2The Catholic University of Korea, Seoul, KOREA, REPUBLIC OF. Bone Density In Moderate To Severe Asthma In Northern Alberta and British Columbia L. Ghazala, H. Banh, E. Wright, J. Beach, D. Morrish, D. Vethanayagam; University Of Alberta, Edmonton, AB, CANADA. Sensitization to Cockroaches: Comparison Between Different Allergenic Extracts for Skin Prick Test E. C. Sarinho1, M. I. L. Lopes1, P. Miranda1, J. A. Rizzo1, A. R. Silva1, D. Medeiros1, D. Solé2; 1Federal University of Pernambuco, Recife, BRAZIL, 2UNIFESPEPM, São Paulo, BRAZIL. Quality Of Life Assessment In Wheezy Infants Before And After Using Montelukast(singulair) M. Kwofie-Mensah, R. J. Green, R. Masekela, O. Kitchin, T. Moodley; Steve Biko Academic Hospital, Pretoria, SOUTH AFRICA.

Autoimmunity, HIV, and Other BCI Topics 5203 Session Time: Tuesday, March 22, 2011 9:45:00 AM - 10:45:00 AM

872 Parvovirus Arthritis Mimicking Early Rheumatoid Arthritis S. Yamao, K. Yamaguchi, Y. Matsui, M. Okada; St. Luke’s International Hospital, Tokyo, JAPAN. 873 Defective Peripheral B Cell Tolerance In Alps Patients With Fas Mutations C. C. Price1, V. K. Rao2, S. Danielian3, E. Meffre1; 1Yale University, New Haven, CT, 2National Institutes of Health, Bethesda, MD, 3Hospital de Pediatria Juan P Garrahan, Buenos Aires, ARGENTINA. 874 Efficacy and Safety of Canakinumab in a Large Cohort of Cryopyrin-Associated Periodic Syndrome (CAPS) Patients across All Severity Phenotypes

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1University of Virginia, Charlottesville, VA, 2University of Umea, Umea, SWEDEN. Association between Eosinophilic Airway Inflammation and Persistent Airflow Limitation in Asthmatic Children Y. Lee1,2, H. Lee3, K. Kim1,2, M. Sohn1,2, K. Kim1,2; 1Yonsei University College of Medicine, Seoul, Korea, Seoul, KOREA, REPUBLIC OF, 2Institute of Allergy, BK21 Project for Medical Science, Research Center for Human Natural Defense System, Seoul, KOREA, REPUBLIC OF, 3Kwandong University College of Medicine, Goyang, KOREA, REPUBLIC OF. Aspirin Desensitization in the Office Setting R. S. Dunn1, R. W. Hendershot2; 1University of Utah School of Medicine, Salt Lake City, UT, 2Intermountain Health Care, Salt Lake City, UT. The Asthma Control Test (ACT) Cutoff for Asthma Control May Be Higher in Hispanic Children Y. Shi1, A. S. Aledia1, J. T. Nguyen1, A. V. Tatavoosian1, S. C. George1,2, S. P. Galant3; 1Biomedical Engineering, University of California, Irvine, Irvine, CA, 2Chemical Engineering, University of California, Irvine, Irvine, CA, 3Children’s Hospital of Orange County, Orange, CA. Management of High Risk Asthma Patients Involves Mental Health Evaluation K. A. Gonzaga, M. C. Zacharisen, P. Marik, M. Vasudev; Medical College of Wisconsin, Milwaukee, WI. The Effect of Aerobic Exercise on Asthma-Related Responses in Adults A. W. Boyd, K. Estell, M. Dransfield, L. Schwiebert; University of Alabama at Birmingham, Birmingham, AL.

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R. Cartwright1, J. Smith2, P. Hawkins3, J. Kuemmerle-Deschner4, E. Hachulla5, I. Kone-Paut6, J. Hoyer7, P. Quartier8, M. Gattorno9, A. Widmer10, N. Patel11, R. Preiss11, K. Leslie12; 1Allergy Center at Brookstone, Columbus, GA, 2University of Wisconsin, Madison, WI, 3University College London Medical School, London, UNITED KINGDOM, 4Klinik fuer Kinder- und Jugendmedizin, Tuebingen, GERMANY, 5Hôpital Claude Huriez CHRU, Lille, FRANCE, 6Hôpital Kremlin Bicetre, Kremlin Bicetre, FRANCE, 7Department of Internal Medicine and Nephrology, Universitätsklinikum Giessen und Marburg GmbH, Marburg, GERMANY, 8Unité d’Immunologie, Hematologie et Rheumatologie Pediatrique, Hopital Necker-Enfants Malades, Paris, FRANCE, 9Istituto Giannina Gaslina, Genova, ITALY, 10Novartis Pharma AG, Basel, SWITZERLAND, 11Novartis Pharmaceuticals, East Hanover, NJ, 12UCSF School of Medicine, San Francisco, CA. Canakinumab Reduces The Risk Of Acute Gouty Arthritis Flares During Initiation Of Allopurinol Therapy: Results Of A Double-blind, Randomised Study N. Schlesinger1, E. Mysler2, H. Lin3, M. DeMeulenmeester4, J. Rovensky5, U. Arulmani6, A. Balfour6, G. Krammer6, P. Sallstig7, A. So8; 1UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, 2Organizacion Medica de Investigation, Buenos Aires, ARGENTINA, 3Taipei Veterens General Hospital, Taipeh, TAIWAN, 4Private Practice, Gozee, BELGIUM, 5NURCH, Piestany, SLOVAKIA, 6 Novartis Pharma AG, Basel, SWITZERLAND, 7Novartis Pharma Ag, Basel, SWITZERLAND, 8University of Lausanne, Lausanne, SWITZERLAND. Canakinumab Relieves Symptoms of Acute Flares and Improves Health-Related Quality Of Life (HRQoL) in DifficultTo-Treat Gouty Arthritis Patients by Suppressing Inflammation: Results of a Randomized, Dose-Ranging Study A. So 1, M. DeMeulenmeester2, E. Yücel 3, U. Arulmani 4, D. Richard4, V. Murphy4, P. Sallstig4, N. Schlesinger5; 1University of Lausanne, Lausanne, SWITZERLAND, 2Private Practice, Gozee, BELGIUM, 3Baskent University, Ankara, TURKEY, 4Novartis Pharma AG, Basel, SWITZERLAND, 5UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ. First Reported Cases Of Schnitzler Syndrome Successfully Treated With Canakinumab (anti-IL-1-beta) R. Fox, R. D. Pesek; University of South Florida, Tampa, FL. Case Series of the Effectiveness of Montelukast for Periodic Fever Syndromes T. L. Mertz, T. Prematta, F. Ishmael, B. P. Groh; Penn State Hershey Medical Center, Hershey, PA. Immunophenotype of Myeloid and Plasmacytoid Dendritic Cells in Patients with Multiple Sclerosis A. Y. Hancharou1, L. P. Titov1, I. U. Ramanava1, L. M. DuBuske2; 1Republican Scientific and Practical Center for Epidemiology and Microbiology, Minsk, BELARUS, 2Immunology Research Institute of New England, Gardner, MA. Impact of a Polymorphisms of Toll Like Receptor 4 Genes on Anti-endotoxin Immunity in Patients with Rheumatoid Arthritis and Non Steroidal Anti-Inflammatory Drug Induced Gastropathy V. Biloglazov1, K. Byeloglazova1, L. DuBuske2; 1 Crimea State Medical University, Simferopol, UKRAINE, 2 Immunology Research Institute of New England, Gardner, MA. Patient derived HIV-1 Env Amplicons Demonstrate Trophic Shift from CCR5 to CXCR4 Use S. A. Leibel, L. Ratner; Washington University in St. Louis, St. Louis, MO.

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

882 Lack of HIV-1 Resistance Development in the Presence of the Natural Antiviral Compound, Epigallocatechin Gallate C. Nance1, R. Ptak2, J. Russell2, P. Hogan2, W. Shearer1; 1Baylor College of Medicine, Houston, TX, 2Southern Research Institute, Frederick, MD. 883 Increased Report Of Perinatal Hiv Transmission Without Breach Of Current Testing Guidelines At A Children’s Hospital HIV Clinic S. Z. Faghih; Children’s Hospital Of Michigan, Detroit, MI. 884 Long Term Persistence of IgE Anti-Influenza A HIN1 Virus Antibodies in Serum of Pediatric and Adult Humans Post Influenza A H1N1 Infection M. Kusonruksa 1, D. Wong 1, K. B. Norowitz 1, R. Joks 1, H. G. Durkin1, M. H. Bluth2, T. A. Smith-Norowitz1; 1State University of New York Downstate Medical Center, Center for Allergy and Asthma Research, Brooklyn, NY, 2Wayne State University School of Medicine, Department of Pathology, Detroit, MI. 885 Detection Of Antibodies Against Neuronal Antigens In 157 Patients: Diagnostic Tool For Paraneoplastic Neurological Syndromes (PNS) Y. Barrios1, M. Pueyo2, C. Croissier2, A. Franco1; 1Immunology Section Hospital Universitario Canarias, Tenerife Spain, SPAIN, 2Neurology Department Hospital Universitario Canarias, Tenerife Spain, SPAIN. 886 Heme Oxygenase-1 (HO-1) and the Immunomodulatory Effects of Extracorporeal Photopheresis (ECP) S. Kankirawatana1, J. F. George2; 1Division of Allergy and Immunology, Children’s Hospital, Birmingham, AL, 2Division of Cardiothoracic Surgery, UAB, Birmingham, AL. 887 Clinical Features Of The Relationship Between IgG4 And Sclerosing Lesions M. Tatewaki, K. Kurasawa, H. Hirata, M. Watanabe, R. Maezawa, K. Sugiyama, Y. Fukushima, T. Fukuda; Dokkyo University School of Medicine, Mibuchi, JAPAN. 888 G Protein Coupled Receptor Kinase 3 (GRK3) Negatively Regulates CXCL12/CXCR4 Signaling and Tumor Migration in Breast Cancer D. J. Fitzhugh, M. W. McGinnis, R. Timoshchenko, R. Lininger, N. Demore, J. Serody, T. K. Tarrant; University of North Carolina, Chapel Hill, NC. 889 The Adaptive Immune Response in Cutaneous MethicillinResistant Staphylococcus Aureus Infections I. A. Myles, C. Fowler, P. Valdez, S. Datta; The National Institutes of Health, Bethesda, MD. 890 Response to Cutaneous Immunization with Low Molecular Weight Subunit Keyhole Limpet Hemocyanin (KLH) H. Milgrom1, K. L. Kesler2, M. Byron2, R. J. Harbeck1, R. Holliday2, D. Y. Leung1; 1National Jewish Health, Denver, CO, 2Rho Inc, Chapel Hill, NC. 891 Evidence of macrophage activation in Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAs) M. Longley, E. Kellner, S. Hudey, S. Lukas, P. Sriaroon, J. Sleasman, E. Perez, T. Murphy, M. Dorsey; University of South Florida/All Children’s Hospital, St. Petersburg, FL. 892 Differences in Regulatory Capacity of Umbilical Cord Blood Mononuclear Cells Based on Maternal Atopic Risk K. M. Fraser, A. K. Ellis; Queen’s University, Kingston, ON, CANADA. 893 Characterization Of Children With Autism Spectrum Disorders (asd) Requiring Intravenous Immunoglobulin (ivig) For Specific Polysaccharide Antibody Deficiency (spad)/

Abstracts  AB319

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

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Hereditary Andiodema 5204 Session Time: Tuesday, March 22, 2011 9:45:00 AM - 10:45:00 AM

899 At-Home Treatment of Patients with Acute Attacks of Hereditary Angioedema with the Bradykinin B2 ReceptorAntagonist Icatibant H. Farkas, D. Csuka, Z. Zotter, L. Varga, Z. Böröcz, G. Temesszentandrási, I. Karádi; Semmelweis University, Budapest, HUNGARY. 900 Clinical Features and Outcome of 52 Patients with Hereditary Angioedema F. L. D’Ottaviano, L. K. Tanno, J. Kalil, A. A. Motta, P. GiavinaBianchi; University of São Paulo, São Paulo, BRAZIL.

901 Prevalence of Autoantibodies in a Group of Hereditary Angioedema Patients S. DORTAS JR, S. O. R. Valle, S. A. P. Levy, A. T. Abe, R. P. Tortora, G. V. Pires, J. S. Papi, A. T. França; Universidade Federal do Rio de Janeiro, Rio de Janeiro, BRAZIL. 902 Safety and Efficacy of Nanofiltered C1 Esterase Inhibitor (Human) (Cinryze™) for the Treatment of Laryngeal Attacks in Subjects with Hereditary Angioedema (HAE) M. Riedl1, J. Baker2, D. Hurewitz3, W. R. Lumry4, A. Vegh5, M. White6, J. A. Grant7, P. Busse8, A. Rubinstein9, I. Kalfus10; 1UCLA David Geffen School of Medicine, Los Angeles, CA, 2Baker Allergy, Asthma, and Dermatology Research Center, Lake Oswego, OR, 3Allergy Clinic of Tulsa, Tulsa, OK, 4William R. Lumry, M.D., P.A., a Professional Association, Dallas, TX, 5Puget Sound Allergy Asthma, Tacoma, WA, 6Institute for Asthma & Allergy, Wheaton, MD, 7University of Texas Medical Branch, Galveston, TX, 8Mount Sinai School of Medicine, New York, NY, 9Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, 10M2G Consultants, New York, NY. 903 Pre-procedure Administration of C1 Esterase Inhibitor (Human) (Cinryze™) for the Prevention of Hereditary Angioedema (HAE) Attacks after Medical, Dental, or Surgical Procedures W. R. Lumry 1, P. Busse 2, J. Baker 3, M. Davis-Lorton 4, D. Hurewitz5, J. A. Grant6, M. White7, I. Kalfus8; 1William R Lumry MD, PA, A Professional Association, Dallas, TX, 2Mount Sinai School of Medicine, New York, NY, 3Baker Allergy, Asthma, and Dermatology Research Center, LLC, Lake Oswego, OR, 4Winthrop University Hospital, Mineola, NY, 5Allergy Clinic of Tulsa, Tulsa, OK, 6University of Texas Medical Branch, Galveston, TX, 7Institute for Asthma & Allergy, Wheaton, MD, 8M2G Consultants, New York, NY.

Food Allergy 5205 Session Time: Tuesday, March 22, 2011 9:45:00 AM - 10:45:00 AM

904 Matsutake Mushroom-induced Anaphylactic Reaction: The Patient’s Nonreleasing Basophils Showed Antigen-induced Histamine Release After 3-day Treatment With IL-3 T. Toda, M. Yamaguchi, Y. Nakase, N. Sugimoto, M. Suzukawa, A. Kamiyama, H. Yoshihara, M. Kuramochi, H. Tashimo, H. Arai, H. Nagase, K. Ohta; Teikyo University School of Medicine, Tokyo, JAPAN. 905 Inhibition of Pim1/3 Kinase Prevents Peanut-Induced Diarrhea and Intestinal Inflammation by Enhancing Runx3 Expression and Suppressing Th2 and Th17 Cell Differentiation M. Wang, J. Domenico, M. Okamoto, S. Ashino, Y. Shin, E. W. Gelfand; National Jewish Health, Denver, CO. 906 Assessment and Management of Specific Emotional and Behavioural Problems in Paediatric Food Allergy A. DunnGalvin, J. O. B. Hourihane; University College Cork, Cork, IRELAND. 907 Hemocyanin, Troponin C and Fatty Acid-binding Protein (FABP) May be Cross-reactive Allergens Between Crustaceans, Cockroach and Dust Mites R. Ayuso 1, G. Grishina 1, M. Pascal 2, S. Sanchez-Garcia 3, D. Towle4, C. Smith4, M. Ibáñez3, H. A. Sampson1; 1Mount Sinai Medical Center, New York, NY, 2Hospital Clinic Barcelona, Barcelona, SPAIN, 3Hospital Universitario Niño Jesus, Madrid, SPAIN, 4MDI Biological Lab, Maine, ME. 908 Assessment of Dietary Restrictions in New Referrals to Pediatric Allergy Clinic

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hypogammaglobulinemia - Distinct Patterns Of Cytokine Production And Gene Expression Profiles H. Jyonouchi, L. Geng, S. Kapoor, D. Streck, G. Toruner; UMDNJ-New Jersey Medical School, Newark, NJ. Levels of IgE in Acute Nephritis Patients as Related to the Efficacy of Treatment R. Khanferyan1, N. Fedicheva1, J. Shakhrai1, L. Gorbov1, L. M. DuBuske2; 1 Kuban State Medical University, Krasnodar, RUSSIAN FEDERATION, 2Immunology Research Institute of New England, Gardner, MA. In vitro Effect of oxLDL and PHA on Lymphocyte Proliferation/ Cytotoxicity and Interleukin-2 Production in Patients with Atherosclerosis M. Mahmoudi1, F. Siassi1, M. J. Mahmoudi2, F. Shokri3, M. Eshraghian4, A. Zarnani5, N. Rezaei6, A. Saboor-Yaraghi1; 1Department of Nutrition, School of Public Health, Tehran University of Medical Sciences, Tehran, IRAN, ISLAMIC REPUBLIC OF, 2Division of Cardiology, Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, IRAN, ISLAMIC REPUBLIC OF, 3Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, IRAN, ISLAMIC REPUBLIC OF, 4Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, IRAN, ISLAMIC REPUBLIC OF, 5Nanobiotechnology Research Center, Avicenna Research Institute, Tehran, IRAN, ISLAMIC REPUBLIC OF, 6Molecular Immunology Research Center; and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, IRAN, ISLAMIC REPUBLIC OF. Orai1/CRACM1 Gene Single Nucleotide Polymorphisms And Kawasaki Disease In Taiwanese Children H. C. Kuo1,2, K. D. Yang1, H. R. Yu1, C. D. Liang1, W. C. Chang3; 1Chang Gung Memorial Hospital-Kaohsiung Medical Center, Taiwan, Kaohsiung, TAIWAN, 2Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Kaohsiung, TAIWAN, 3Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung County, TAIWAN. Influence of Omalizumab on Genes Involved in Regulation of IgE Synthesis M. A. Chan, N. M. Gigliotti, L. J. Rosenwasser; Children’s Mercy Hospital, Kansas City, MO. Prostaglandin I 2 Signaling Exacerbates Experimental Autoimmune Encephalomyelitis D. R. Dowell1, W. Zhou1, M. M. Huckabee1, D. C. Newcomb1, K. Goleniewska1, G. A. Fitzgerald2, R. S. Peebles, Jr.1; 1Vanderbilt University, Nashville, TN, 2University of Pennsylvania, Philadelphia, PA.

AB320 Abstracts

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M. Szymanska, Y. Yanishevsky, D. Daly, C. Cullinane, J. Hourihane; University College Cork, Cork, IRELAND. Localization On Caprine b-casein Of The Epitopes Specifically Recognized By Ige From Patients Allergic To Goat’s Milk And Tolerant To Cow’s Milk S. Ah-Leung1, S. Tilleul1, S. Hazebrouck1, K. Adel-Patient1, E. Paty2, P. Scheinmann2, J. M. Wal1, h. Bernard1; 1INRA, Gif sur Yvette, FRANCE, 2Hôpital Necker Enfants Malades, Paris, FRANCE. Sensitization to Profilin in Japanese Patients with Pollen-Food Allergy Syndrome: Its Source of Sensitization and Clinical Relevance Y. Fukutomi1,2, M. Taniguchi1, S. Nakayama3, A. Tanaka3, A. Saito1, H. Yasueda1, T. Nakazawa1, M. Hasegawa1, H. Nakamura2, K. Akiyama1; 1 Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara Kanagawa, JAPAN, 2Department of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, JAPAN, 3Phadia K.K., Tokyo, JAPAN. Role Of Disulfide Bridges In The Proteolytic Susceptibility And Allergenicity Of Ara H 6, A Major Allergen From Peanut B. Guillon 1, S. Hazebrouck 1, K. Adel-Patient 1, E. Paty 2, P. Scheinmann2, J. M. Wal1, H. Bernard1; 1INRA, Gif sur Yvette, FRANCE, 2Hôpital Necker Enfants Malades, Paris, FRANCE. The Use of Epinephrine for the Treatment of Initial Allergic Reactions to Peanut M. Ben-Shoshan1, L. Soller2, R. Alizadehfar1, J. Fragapane3, L. Joseph3,4, Y. St. Pierre3, L. Harada5, M. Allen6, A. Clarke3,7; 1McGill University Montreal Children Hospital, Montreal, QC, CANADA, 2Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Center, Montreal, Quebec, Canada, Montreal, QC, CANADA, 3Division of Clinical Epidemiology, Department of Medicine, McGill University Health Center, Montreal, QC, CANADA, 4Departments of Epidemiology and Biostatistics, McGill University, Montreal, QC, CANADA, 5Anaphylaxis Canada, Toronto, ON, CANADA, 6 Allergy/Asthma Information Association, Toronto, ON, CANADA, 7Division of Allergy and Clinical Immunology, Department of Medicine, McGill University Health Center, Montreal, QC, CANADA. Food Avoidance Following Physician Diagnosis Of Food Allergy: Results From A Canadian Study L. Soller1, J. Fragapane1, M. Ben-Shoshan1, D. Harrington2, R. Alizadehfar 1, L. Joseph 1, Y. St-Pierre 1, S. Godefroy 3, S. J. Elliott4, A. E. Clarke1; 1 McGill University, Montreal, QC, CANADA, 2 McMaster University, Hamilton, ON, CANADA, 3Health Canada, Ottawa, ON, CANADA, 4Waterloo University, Waterloo, ON, CANADA. Comparison of Cetirizine to Diphenhydramine in the Treatment of Acute Food Allergic Reactions J. H. Park, J. H. Godbold, D. Chung, H. A. Sampson, J. Wang; Mount Sinai Medical Center, New York, NY. Hydrolysis Of The Milk Allergen b-lactoglobulin Using High Hydrostatic Pressure Abrogates Allergenicity In Vivo I. Lopez Exposito1, R. Chicon2, J. Belloque2, R. López-Fandiño2, C. Berin1; 1Mount Sinai School of Medicine, New York, NY, 2Instituto de Investigación en Ciencias de la Alimentación (CSIC-UAM), Madrid, SPAIN. Correlation Of Specific IgE To Shrimp With Cockroach and Dust Mite Exposure and Sensitization in an Inner City Population J. Wang1, A. Calatroni2, C. M. Visness2, H. A. Sampson1;

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1Mount Sinai Medical Center, New York, NY, 2Rho Federal Systems Division, Inc, Chapel Hill, NC. Impact of Precautionary Statements on Purchasing Practices of Canadians Directly and Indirectly Affected by Food Allergies S. S. Sheth1, M. Ben-Shoshan1, D. W. Harrington2, L. Soller1, L. Joseph 1, Y. St. Pierre 1, S. B. Godefroy 3, S. J. Elliott 4, S. Waserman2, R. Alizadehfar1, L. Harada5, M. Allen6, M. Allen5, A. E. Clarke1; 1McGill University Health Center, Montreal, QC, CANADA, 2 McMaster University, Hamilton, ON, CANADA, 3 Food Directorate, Health Canada, Ottoawa, ON, CANADA, 4University of Waterloo, Waterloo, ON, CANADA, 5Anaphylaxis Canada, Toronto, ON, CANADA, 6 Allergy/Asthma Information Association, Montreal, QC, CANADA. Characterizing Persistent Peanut Allergy D. L. Neuman-Sunshine1, J. A. Eckman1, C. A. Keet1, E. C. Matsui1, R. D. Peng2, P. J. Lenehan1, R. A. Wood1; 1The Johns Hopkins University School of Medicine, Baltimore, MD, 2The Johns Hopkins University School of Public Health, Baltimore, MD. Allergic Reactions to Diphtheria, Tetanus, and Acellular Pertussis Vaccines Among Children with Milk Allergy J. D. Kattan, A. L. Cox, A. Nowak-Wegrzyn, G. Gimenez, L. Bardina, H. A. Sampson, S. H. Sicherer; Mt. Sinai School of Medicine, New York, NY. Cross Cultural Comparisons of Irish and Australian Children and Teens Living with Food Allergy: The SchoolNuts Study N. Bertalli1, K. Allen1, J. Hourihane2, A. DunnGalvin2; 1Royal Children’s Hospital, Melbourne, AUSTRALIA, 2University College Cork, Cork, IRELAND. Tannic Acid as a Means to Remove Peanut Allergens S. Chung, E. T. Champagne; USDA, New Orleans, LA. Parental Opinions About Food Allergen Labeling of Pharmaceutical Products J. Ross1, C. Weiss2, J. Bradsher2, M. Greenhawt1; 1University of Michigan, Ann Arbor, MI, 2The Food Allergy & Anaphylaxis Network, Fairfax, VA. Pilot Study of a Coping and Management Skills Group for Preadolescents with Food Allergy and their Parents J. S. LeBovidge, M. Pistiner, L. A. Kalish, L. C. Schneider; Children’s Hospital Boston, Boston, MA. Food Allergy Related Pediatric Constipation: Appropriate Time Of Tolerance E. I. Syrigou1, I. Panagiotou2, G. Chouliaras2, K. Pitsios1, M. Kanariou3, E. Roma2; 1Allergy Department Sotiria General Hospital, Athens, GREECE, 21st Dept of Pediatrics, Athens University, Aghia sophia Children’s Hospital, Athens, GREECE, 3Laboratory of Immunology and Compatibility, Aghia Sophia Children’s Hospital, Athens, GREECE. Validation of the Consortium of Food Allergy Research (COFAR) Food Allergy Educational Program (FAEP): One Year Follow-Up P. A. Vargas1, M. Groetch2, L. Christie3, S. M. Jones3, S. H. Sicherer2; 1Arizona State University, Phoenix, AZ, 2Mount Sinai School of Medicine, New York, NY, 3University of Arkansas for Medical Sciences, Little Rock, AR. An Investigation of Food Choice Behaviour of Food Allergic and Non-Food Allergic Consumers I. Sommer, H. MacKenzie, C. Venter, T. Dean; University of Portsmouth, Portsmouth, UNITED KINGDOM. Parental Distress in Food Allergy: Needs Assessment for Mental Health (MH) Referrals E. Shemesh1, R. Annunziato1, C. C. Weiss2, G. N. Izzo3, C. D’Urso3, L. Batemarco3, S. H. Sicherer1;

Abstracts  AB321

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

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CIBER de Enfermedades Respiratorias (CIBERES, Madrid, SPAIN, 5Research Laboratory for Allergic Diseases, Carlos Haya Hospital-Fundacion IMABIS, Malaga, SPAIN, 6Paul-EhrlichInstitut, Federal Institute for Vaccines and Biomedicines. Division of Allergology, Langen, GERMANY, 7Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines. Division of Allergology, Langen, SPAIN. Safe Administration of Influenza Vaccine to Egg Allergic Children Using a Two Step Protocol G. R. Owens, Jr., A. J. MacGinnitie; Children’s Hospital of Pittsburgh- UPMC, Pittsburgh, PA. “Real World” Influenza Vaccination Practice Patterns in EggAllergic Patients S. Mithani1, S. Schuval1,2; 1North Shore- Long Island Jewish Health System, Great Neck, NY, 2Hofstra North Shore-Long Island Jewish School of Medicine, Hempstead, NY. Further Evidence For Tick Bites As A Cause Of The IgE Responses To Alpha-gal That Underlie A Major Increased In Delayed Anaphylaxis To Meat H. R. James1, S. P. Commins1, L. A. Kelly1, S. L. Pochan1, L. J. Workman1, R. J. Mullins2, T. A. E. Platts-Mills1; 1University of Virginia, Charlottesville, VA, 2John James Medical Centre, Canberra, AUSTRALIA. Elevation of Serum IL-17 Levels was Demonstrated after Oral Food Challenge in Infants with Food Protein-Induced Enterocolitis Syndrome T. Shoda1,2, K. Hashimoto3, H. Morita4, I. Nomura1, A. Isozaki2, Y. Ohya1, T. Ichiyama3, H. Saito4, K. Matsumoto4, Y. Kawano2; 1Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, JAPAN, 2Department of Pediatrics, Medical Center for Allergy and Immune diseases, Yokohama City Minato Red Cross Hospital, Yokohama, JAPAN, 3Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, JAPAN, 4Department of Allergy and Immunology, National Research Institute for Child Health & Development, Tokyo, JAPAN. Identification of Probiotic Strains Capable of Gluten Peptide Degradation K. J. Clark1, C. Hernández Gaitán1, S. L. Taylor2, J. Walter1; 1University of Nebraska, Lincoln, NE, 2Food Allergy Research and Resource Program, University of Nebraska, Lincoln, NE.

Anaphylaxis/Insect/Latex/Drug Allergy & Mastocytosis 5206 Session Time: Tuesday, March 22, 2011 9:45:00 AM - 10:45:00 AM

943 Posaconazole Desensitization Protocol J. J. Reed1, K. Sweiss1, P. K. Muniyappa2; 1University of Illinois at Chicago, Chicago, IL, 2Mercy Hospital & Medical Center, Chicago, IL. 944 Mortality Due To Cow’s Milk Protein (CMP) Allergy in Israel E. Tabachnik1, M. Goldberg2, M. B. Levy3, Y. Katz3; 1Kaplan Medical Center, Rehovot, ISRAEL, 2Assaf-Harofeh Medical Center, Zerifin, ISRAEL, 3Assaf Harofeh Medical Center, Zerifin, ISRAEL. 945 Epinephrine Autoinjectors For The First-aid Treatment Of Anaphylaxis: Epinephrine Dose Ejected After 11-13 Years In Controlled Storage Conditions K. J. Simons1, O. M. Rachid1, M. M. Rawas-Qalaji2, E. R. Simons1; 1University of Manitoba, Winnipeg, MB, CANADA, 2Nova Southeastern University, Fort Lauderdale, FL.

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1Mt. Sinai School of Medicine, New York, NY, 2the Food Allergy & Anaphylaxis Network, Fairfax, VA, 3Fordham University, New York, NY. Peanut Sensitization in a Group of Allergic Egyptian Children E. Hossny1, G. Gad1, A. Shehab2, A. El-Haddad1; 1Pediatric Allergy and Immunology Unit, Ain Shams University, Cairo, EGYPT, 2Clinical Pathology Department, Ain Shams University, Cairo, EGYPT. Bioactivities of Berberine, Palmatine, and Jatrorrhizine isolated from Food Allergy Herbal Formula 2 (FAHF-2) N. Yang, Y. Song, H. Sampson, X. Li; MountSinai School of medicine, New York City, NY. Parental Atopy Is Not A Risk Factor For Ige-Mediated Cow’s Milk Protein Allergy (Ige-CMA) M. Goldberg1, E. Eisenberg2, N. Rajuan1, M. Rachmiel1, A. Cohen1, A. Elizur1, G. Zadik-Mnuchin1, Y. Katz1; 1Assaf-Harofeh Medical Center, Zerifin, ISRAEL, 2Tel Aviv University, Tel Aviv, ISRAEL. The Serological Comparison between Alcohol-soluble Protein of Maize And Wheat K. Lee, M. Kim, J. Hong, K. Kim, M. Sohn, K. Kim; Department of Pediatrics, Institute of Allergy, Medical research institute, Brain Korea 21 project for Medical science, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF. An Educational Intervention Can Improve Quality of Life in Food Allergic Families S. I. Dever, N. Polmear-Swendris, M. McMorris, A. Baptist; University of Michigan, Ann Arbor, MI. Inhibition of IgE Production By Chemical Constituents Isolated From Qumai (Dianthus Superbus) P. Slotkin, B. Liang, C. Liu, X. Li, N. Yang; MountSinai School of medicine, New York City, NY. Reaction Due To Milk Proteins Contaminating Lactose Added To Inhaled Corticosteroid A. B. Sa1, L. C. L. Oliveira1, K. V. M. Miyagi2, Y. A. M. F. Mello2, E. C. Cabral2, A. P. E. Carvalho2, F. F. Komaroff2, R. F. F. Gonçalves2; 1Universidade Federal de São Paulo, São Paulo, SP, BRAZIL, 2Clinica de Alergia São Paulo, São Paulo, SP, BRAZIL. Levels of Histamine and other Biogenic Amines in Red Wines and Sparkling Wines V. Konakovsky1, M. Focke2, K. Hoffmann-Sommergruber2, R. Schmid3, O. Scheiner2, P. Moser4, W. Hemmer1, R. Jarisch1; 1Floridsdorf Allergy Center, Vienna, AUSTRIA, 2Department of Pathophysiology, Centre for Physiology and Pathophysiology, Medical University of Vienna, Vienna, AUSTRIA, 3Clinical Institute of Medical & Chemical Laboratory Diagnostics, Medical University Vienna, Vienna, AUSTRIA, 4Falstaff Magazine, Klosterneuburg, AUSTRIA. Impact of Food Challenge Tests on Children’s and Parent’s Health Related Quality of Life: A Time Series Case-Control Study. J. O. B. Hourihane1, A. E. J. Dubois2, B. Flokstra-DeBlok2, A. DunnGalvin1; 1 University College Cork, Cork, IRELAND, 2 Groningen Universiteit, Groningen, NETHERLANDS. Ara H 9 Is The Main Allergen In Peanut Allergic Patients In The Mediterranean Area Regardless The Symptom Severity M. Ferrer1, G. Javaloyes1, I. García Nuñez2, G. Gastaminza1, M. Goikoetxea1, C. Gamazo3, J. Souza3, B. Sastre4, V. del Pozo4, M. Blanca5, S. Vieths6, S. Scheurer7, M. L. Sanz1; 1Clinica Universidad de Navarra, Pamplona, SPAIN, 2bResearch Laboratory for Allergic Diseases, Carlos Haya Hospital-Fundacion IMABIS, Malaga, SPAIN, 3Adjuvant Unit, Department of Pharmacy and Pharmaceutical Technology, and Department of Microbiology, University of Navarra, Pamplona, SPAIN, 4Immunology Department, IIS-Fundación Jiménez-Díaz and

AB322 Abstracts

TUESDAY

946 Comprehensive Anaphylaxis Management in Schools and Childcare through Resources, Legislation and Adrenaline Autoinjector Provision R. Loh, L. Sprigg, V. Noble, S. Vale; on behalf of the Anaphylaxis Management Implementation Group, Perth, WA, Perth, AUSTRALIA. 947 Epinephrine Use In Anaphylaxis In A Spanish Emergency Room A. Alvarez-Perea, T. Margarita, M. Patricia, P. Diana, M. Guadalupe, B. María Luisa; Hospital General Universitario Gregorio Marañón, Madrid, SPAIN. 948 Anaphylactic Reactions to Oligosaccharides: A New and Evolving Syndrome H. S. Saleh, D. Chi, G. Krishnaswamy; James H. Quillen College of Medicine and Mountain Home VA Medical Center, East Tennessee State University, Johnson City, TN. 949 Enhanced IL-4 Receptor Signaling Promotes IgE-mediated Systemic Anaphylaxis and Impaired Tolerance to Food Antigens C. B. Mathias1, S. A. Hobson2, M. Garcia-Lloret2, G. Lawson2, D. Poddighe1, E. Freyschmidt1, W. Xing3, M. F. Gurish4, T. A. Chatila2, H. C. Oettgen1; 1 Children’s Hospital Boston and Harvard Medical School, Boston, MA, 2University of California at Los Angeles, Los Angeles, CA, 3Brigham and Women’s Hospital, Boston, MA, 4Brigham and Women’s Hospital and Harvard Medical School, Boston, MA. 950 IgE to Alpha-Gal: Clinical and In Vitro Evidence of a Delayed Reaction to Mammalian Meat S. P. Commins, H. R. James, S. L. Pochan, L. J. Workman, T. A. E. Platts-Mills; University of Virginia, Charlottesville, VA. 951 Anaphylaxis Training Packages for Health Professionals in Australia and New Zealand R. Mullins, S. Vale, J. Smith, G. Dunne, P. Smith, V. Smith, S. Grainger, R. Loh; on behalf of the ASCIA Anaphylaxis Working Party, Sydney, AUSTRALIA. 952 Effectiveness of Helminths in Two Different Mice Strains in a Murine Model of Anaphylaxis G. Marco, A. La Rotta, A. Rodriguez, M. Baeza; Hospital General Universitario Gregorio Marañón, Madrid, SPAIN. 953 A Survey Study of Food-Related Allergic Reactions and Anaphylaxis Management T. D. Green1, T. S. Jacobs1, L. Mitchell2, M. J. Greenhawt3, D. Hauswirth4, S. Clark5; 1Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 2 KidswithFoodAllergies.org, Doylestown, PA, 3 C. S. Mott Children’s Hospital of UMHS, Ann Arbor, MI, 4The Ohio State University Medical Center and Nationwide Children’s Hospital, Columbus, OH, 5University of Pittsburgh, Pittsburgh, PA. 954 What Proportion Of Epinephrine Autoinjector Pen Prescriptions Are Appropriate? S. Gilbert1, T. Isinkaye1, P. Seddon2, H. Smith1; 1Brighton and Sussex Medical School, Brighton, UNITED KINGDOM, 2Department of Paediatrics, Brighton and Sussex University Hospital Trust, Brighton, UNITED KINGDOM. 956 A Seventeen-Year Review of Peri-Operative Anaphylaxis in a Pediatric Hospital J. S. Tam1, K. Kelly1, J. A. Pongracic2;

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

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964

1Medical College of Wisconsin, Milwaukee, WI, 2Children’s Memorial Hospital, Chicago, IL. Anaphylaxis in Latin America: a Report of the Online Latin American Survey on Anaphylaxis (OLASA) D. Sole1, J. Ivancevich2, M. S. Borges3, M. A. Quadros-Coelho4, N. A. Rosario5, L. Ardusso2, L. G. Bernd6, S. L. A. I. Latin American Anaphylaxis Group7; 1Federal University of Sao Paulo, Sao Paulo, BRAZIL, 2SLAAI, Buenos Aires, ARGENTINA, 3SLAAI, Caracas, VENEZUELA, BOLIVARIAN REPUBLIC OF, 4UNIMONTES, Montes Claros, BRAZIL, 5Federal University of Paraná, Curitiba, BRAZIL, 6Federal University of Rio Grande do Sul, Porto Alegre, BRAZIL, 7SLAAI, São Paulo, BRAZIL. The Ten Study: Time Epinephrine Needs to Reach Muscle T. W. Baker1, C. M. Webber1, A. C. Bush2, E. Gonzalez-Reyes1; 1Wilford Hall Medical Center, Department of Allergy and Immunology, San Antonio, TX, 2Wilford Hall Medical Center, Clinical Research Division, San Antonio, TX. Anaphylaxis To Oral Poliovirus Vaccine In Children With Cow Milk Protein Allergy C. A. S. Parisi, J. F. Maspero, M. E. Gervasoni, P. Smaldini, G. Docena, MD; Fundación CIDEA, Buenos Aires, ARGENTINA. Registry Of Severe Allergic Reactions: The Experience Of Piemonte, Italy A. Raie1, G. Cadario2, M. Galimberti3, S. Mietta1, F. Nebiolo1, E. Heffler1, I. Badiu1, G. Rolla1; 1Allergy & Clinical Immunology University of Torino, TORINO, ITALY, 2S.C. Allergologia e Immunologia Clinica AOU San Giovanni, TORINO, ITALY, 3Allergy Unit AOU Maggiore e della Carità, NOVARA, ITALY. Validation of the REMA Score for Predicting Systemic Mastocytosis in Patients with Mast Cell Activation Disorders I. Alvarez-Twose1, D. González-de-Olano2, L. Sánchez-Muñoz1, A. Matito1, J. Morgado1, M. Jara-Acevedo3, C. Teodosio3, A. García-Montero3, A. Orfao3, L. Escribano1; 1Instituto de Estudios de Mastocitosis de Castilla La Mancha, Toledo, SPAIN, 2Hospital de Fuenlabrada, Madrid, SPAIN, 3Centro de Investigación del Cáncer/IBMCC, Servicio General de Citometría. Universidad de Salamanca, Salamanca, SPAIN. Population-Based Time Trend and Age Differences in Anaphylaxis Hospitalizations between New York State and Florida Z. D. Mulla1,2, R. Y. Lin3,4, M. R. Simon5,6; 1Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, 2Department of Epidemiology and Biostatistics, University of South Florida College of Public Health, Tampa, FL, 3Department of Medicine, New York Downtown Hospital, New York, NY, 4Department of Medicine, New York Medical College, Valhalla, NY, 5Division of Allergy and Clinical Immunology, William Beaumont Hospital, Royal Oak, MI, 6Departments of Internal Medicine and Pediatrics, Wayne State University School of Medicine, Detroit, MI. Overcoming the Barriers of Distance: Online Anaphylaxis Training for the School and Childcare Sectors in Australia and New Zealand S. Vale, J. Smith, S. Grainger, G. Dunne, M. Raymond, R. Loh; on behalf of ASCIA Anaphylaxis Working Party, Sydney, AUSTRALIA. Idiopathic Anaphylaxis in Infancy S. M. Cooper, D. E. Schuller, T. B. Fausnight; Penn State Milton S Hershey Medical Center, Hershey, PA.

965 Insect Allergy in the Lviv Region of Ukraine V. Chopyak 1, H. Potomkina 1, K. Lishchuk-Yakymovych 1, R. Pukalyak1, L. M. DuBuske2; 1Lviv National Medical University, Lviv, UKRAINE, 2Immunology Research Institute of New England, Gardner, MA. 966 Accidents And Mortality From Honey-bee Stings In Mexico M. Becerril-Angeles; Instituto Mexicano del Seguro Social, Mexico City, MEXICO. 967 Epidemiologic Investigation Of Hornet And Paper Wasp Stings In Forest Workers And Electrical Facility Field Workers In Japan M. Watanabe, H. Hirata, Y. Hayashi, K. Sugiyama, Y. Fukushima, T. Fukuda; Dokkyo University School of Medicine, Mibuchi, JAPAN. 968 Identification of Factors Associated with Latex Sensitization and Allergy in Patients with Spina Bifida L. S. Garro1, F. Peluzzo2, J. Kalil1, A. A. Motta1, P. GiavinaBianchi1; 1University of São Paulo, São Paulo, BRAZIL, 2Assistance Association for Disabled Children - AACD, São Paulo, BRAZIL. 969 Prevalence Of Latex, Latex-Related Fruit Allergens And Pollen Profillins Sensitization In A Group Of Patients With Latex Sensitization And Its Value As Predictors Of Clinical Vs Subclinical Sensitization To Latex M. Pedrosa1,2, E. Garcia-Vena1,2, S. Quirce1,2, T. Caballero1,2; 1University Hospital La Paz, Madrid, SPAIN, 2Hospital La Paz Health Research Institute (IdiPaz), Madrid, SPAIN, Madrid, SPAIN. 970 Irish Spina Bifida Patients Have a Very Low Prevalence of Latex Allergy and Latex Sensitisation C. Cullinane1, O. O’Mahony2, M. Lundberg3, M. Borres3, J. O. Hourihane4; 1University College Cork, Ireland, Cork University Hospital, IRELAND, 2Cork University Hospital, Cork, IRELAND, 3Phadia, Uppsala, SWEDEN, 4University College Cork, Cork, IRELAND. 971 Female Sex is not a Risk Factor for Penicillin Allergy in the Pediatric Population S. J. Fox, M. A. Park; Mayo Clinic, Rochester, MN. 972 Penicillin Allergy Evaluation: Experience from a drug allergy clinic in Kuwait M. S. Al-Ahmad, N. Arifhodzic, N. Al Ahmed, A. Al-Onizi, N. Fakim; Al-Rashed Allergy Center, Kuwait, KUWAIT. 973 Systemic Mastocytosis: Mayo clinic experience since 2 S. Sridhara, J. H. Butterfield, C. R. Weiler; Mayo Clinic, Rochester, MN. 974 Characterization of Patients with Suspected Human Seminal Plasma Hypersensitivity (SPH): An Update J. W. Sublett, J. A. Bernstein; University of Cincinnati, Cincinnati, OH. 975 Cutaneous Allergen Sensitization Primes for Anaphylaxis in an Adjuvant Dependent Manner D. Dunkin, M. Berin, L. Mayer; The Mount Sinai School of Medicine, New York, NY. 976 Increased Hospitalization Rate for Allergic Reaction in Densely Populated Northern States R. C. Van Winkle1,2, S. J. McGeady1,2; 1A.I. duPont Hospital for Children, Wilmington, DE, 2Thomas Jefferson University, Philadelphia, PA. 977 Epidemiology of Drug Hypersensitivity Reactions in an Allergy Service J. Kilimajer, MD, C. Alava, MD, T. Herrero, MD, R. Pelta, MD, P. Tornero, MD, M. De Barrio, MD; Universitiy General Hospital Gregorio Marañon, Madrid, SPAIN.

Abstracts  AB323

978 Gatrointestinal Mastocytosis: An Unexplored Etiology in Chronic Abdominal Pain and GI Dysmotility S. Glover1, N. R. Patel1, P. K. Muniyappa2; 1University of Illinois at Chicago, Chicago, IL, 2Mercy Hospital & Medical Center, Chicago, IL.

Allergic and Nonallergic Rhinitis 5207 Session Time: Tuesday, March 22, 2011 9:45:00 AM - 10:45:00 AM

979 Development of Allergic Rhinitis among Children Previously Diagnosed as Nonallergic Rhinitis J. Praikanahok, P. Vichyanond, N. Visitsunthorn, P. Pacharn, O. Jirapongsananuruk; Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, THAILAND. 980 Increasing Prevalence of Allergic Rhinitis in Korean Children May Be Influenced By the Gene-environment Interaction J. Kwon1, J. Seo1, J. Yu1, M. Kang2, S. Kang3, S. Hong1; 1Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, Seoul, KOREA, REPUBLIC OF, 2Asan Institute for Life Sciences, Seoul, KOREA, REPUBLIC OF, 3University of Ulsan College of Medicine, Seoul, KOREA, REPUBLIC OF. 981 Systemic vs Local Allergic Rhinitis: Clinical and Epidemiological Characteristics F. Gómez1, C. Rondón1, P. Campo1, N. Blanca-López2, R. García1, G. Canto2, M. Blanca1; 1Allergy Service. Carlos Haya Hospital, Málaga, SPAIN, 2Allergy Service Infanta Leonor Hospital, Madrid, SPAIN. 982 Signs and Symptoms of Allergic Rhinitis Produced by the Allergen BioCube Compared to the Environment: A Validation Study M. B. Abelson1,2, P. Gomes1, K. Lane1, N. Arenas1; 1ORA, Andover, MA, 2Schepens Eye Research and Harvard Medical School, Boston, MA. 983 Rhinitis Questionnaire Items Predict Physician-Diagnosed Allergic Rhinitis in Children H. Kim1, L. Levin2, G. K. LeMasters2, D. I. Bernstein1; 1Department of Medicine, University of Cincinnati, Cincinnati, OH, 2Department of Environmental Health, University of Cincinnati, Cincinnati, OH. 984 Aeroallergen Sensitization in Children with Allergic Rhinitis: Prevalence and Risk Associations W. Loh1, W. Chiang1, W. Liew1, H. Lim1, A. Goh1, M. I. Kidon1, B. Abhilash2, H. Tan2, Y. Chen3, O. Chay1; 1KK Women’s and Children’s Hospital, Paediatric Allergy and Immunology, Singapore, SINGAPORE, 2KK Women’s and Children’s Hospital, Department of Paediatric Otolaryngology, Singapore, SINGAPORE, 3Singapore Clinical Research Institute, Biopolis, Singapore, SINGAPORE. 985 Chronic Rhinitis in Pediatric Patients: Epidemiologic Analysis of One Cohort E. A. Erwin1, R. A. Faust2, T. A. E. Platts-Mills3, L. Borish3; 1Nationwide Children’s Hospital, Columbus, OH, 2The Ohio State University, Columbus, OH, 3University of Virginia Asthma and Allergic Diseases Center, Charlottesville, VA. 986 Nonallergic Rhinitis-Identifying Gaps in Research R. Esteitie1, N. S. Jones2, E. Toskala3, A. A. Cruz, MD4, D. G. Powe2, R. Naclerio5, D. J. Shusterman6, P. Lieberman7, J. N. Baraniuk1, J. Mullol8, F. M. Baroody5, M. Wagenmann9, M. White10, G. Scadding11, R. Settipane12, W. Fokkens13, R. Pawankar14, A. Togias15;

TUESDAY

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB324 Abstracts

1Georgetown University, Washington DC, DC, 2Queens Medical Center, Nottingham University Hospitals NHS Trust, Nottingham, UNITED KINGDOM, 3Finnish Institute of Occupational Health, Helsinki, FINLAND, 4Universidade Federal da Bahia, Salvador, BRAZIL, 5University of Chicago, Chicago, IL, 6University of California, San Francisco, CA, 7University of Tennesse College of Medicine, Mmephis, TN, 8HOSPITAL CLINIC - IDIBAPS, BARCELONA, CATALONIA, SPAIN, 9 HNO-Klinik, Universitaetsklinkum Duesseldorf, Duesseldorf, GERMANY, 10Institute for Asthma & Allergy, Wheaton, MD, 11Royal National TNE Hospital, London, UNITED KINGDOM, 12Brown University, Providence, RI, 13Academic Medical Center, Amsterdam, NETHERLANDS, 14Nipon Medical School, Tokyo, JAPAN, 15National Institute of Allergy and Infectious Diseases, Bethesda, MD. 987 Oral Allergy Syndrome and United Airways Disease. Is there a functional connection? C. Lombardi1, G. Passalacqua2, G. Canonica2; 1Allergy Unit, Department of Internal Medicine, Sant’Orsola Hospital, Brescia, Brescia, ITALY, 2Allergy and Respiratory Diseases, DIMI, University of Genoa, Genova, ITALY. 988 Sensitization Patterns to Allergens in Ragweed Allergic Patients from Regions of Hungary Having Different Levels of Ragweed Allergen Exposure K. Nekam1, A. Paldy2, D. Apatini2, D. Magyar2, L. M. DuBuske3; 1Hospital of the Hospitaller Orden of St John, Budapest, HUNGARY, 2National Institute of Environmental Health, Budapest, HUNGARY, 3Immunology Research Institute of New England, Gardner, MA.

IRSOC Cornucopia 5208 Session Time: Tuesday, March 22, 2011 9:45:00 AM - 10:45:00 AM

TUESDAY

989 Bepotastine Besilate Ophthalmic Solution 1.5% Reduces Nonocular Composite Symptom (NOCS) Scores 16 Hours Following Dosing in the Conjunctival Allergen Challenge (CAC) Model of Allergic Conjunctivitis J. A. Gow1, T. T. Macejko2, M. T. Bergmann3, E. Meier1, M. B. Abelson4, J. I. Williams1, T. R. McNamara1; 1ISTA Pharmaceuticals, Inc., Irvine, CA, 2Eye Care Associates of Greater Cincinnati, Fairfield, OH, 3Eye Care Associates of Cincinnati, Cincinnati, OH, 4Ora, Andover, MA. 990 Effect of Nasal Olopatadine on Histamine Skin Prick Reactivity S. G. Gendi1, A. H. Wolff2; 1UMDNJ, South Amboy, NJ, 2UMDNJ, Newark, NJ. 991 Pharmacokinetic Evaluation of BDP HFA Nasal Aerosol and BDP HFA Inhalation Aerosol in Healthy Subjects P. H. Ratner1, A. Melchior2, S. A. Dunbar2, S. K. Tantry2, P. M. Dorinsky2; 1 Sylvana Research, San Antonio, TX, 2 Teva Branded Pharmaceutical Products R&D, Inc., Horsham, PA. 992 Seasonal Eosinophilic Bronchitis due to Cupressus arizonica Pollen Allergy I. D. Bobolea1, P. Barranco1, B. Sastre2,3, M. Fernandez-Nieto2,3, V. del Pozo2,3, S. Quirce1,3; 1La Paz Hospital, Madrid, SPAIN, 2Fundación Jimenez Diaz, Madrid, SPAIN, 3Spanish Network of Centers for Biomedical Research on Respiratory Diseases (CibeRes), Bunyola, Mallorca, SPAIN. 993 Abnormal Pharyngeal pH Testing Predicts Response to Proton Pump Inhibitors in Patients with Chronic Cough and Laryngeal Complaints A. Williams, A. Weltmann, J. Comer; Bend Memorial Clinic, Bend, OR.

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

994 Bepotastine Besilate Ophthalmic Solution 1.5% Produces Strong Clinical Benefit for Ocular Itching Immediately Following Dosing in the Conjunctival Allergen Challenge (CAC) Model of Allergic Conjunctivitis J. C. Clark1, J. I. Williams1, P. J. Gomes2, M. B. Abelson3, J. A. Gow1, T. R. McNamara1; 1ISTA Pharmaceuticals, Inc., Irvine, CA, 2Ora, Inc., Andover, MA, 3Schepens Eye Research Institute, Boston, MA. 995 Bepotastine Besilate Ophthalmic Solution 1.5% Reduces Tearing 16 Hours Following Dosing in the Conjunctival Allergen Challenge (CAC) Model of Allergic Conjunctivitis J. I. Williams1, E. B. McLaurin2, F. K. Kurata3, M. B. Abelson4, J. A. Gow1, T. R. McNamara1; 1ISTA Pharmaceuticals, Inc., Irvine, CA, 2Total Eye Care, PA, Memphis, TN, 3East West Eye Institute, Los Angeles, CA, 4Ora, Inc., Andover, MA. 996 An Evaluation of the Effect of Ciclesonide Hydrofluoroalkane Nasal Aerosol on the Ocular Symptoms of Seasonal Allergic Rhinitis B. Martin1, P. Ratner2, W. Howland3, C. Andrews4, H. Huang5, S. Y. Desai5, F. Bode5; 1Southwest Allergy and Asthma Center, San Antonio, TX, 2Sylvana Research Associates, San Antonio, TX, 3Sirius Clinical Research, Austin, TX, 4Diagnostics Research Group, San Antonio, TX, 5Sepracor Inc, Marlborough, MA.

T cells 5209 Session Time: Tuesday, March 22, 2011 9:45:00 AM - 10:45:00 AM

997 Ex Vivo Characterization of the CD4+ T Cell Response to Ara h 1 J. H. DeLong1, K. Hetherington2, E. Wambre1, D. Robinson3, W. W. Kwok1,4; 1Benaroya Research Institute, Seattle, WA, 2Austin Regional Clinic, Austin, TX, 3Virginia Mason Medical Center, Seattle, WA, 4University of Washigton, Seattle, WA. 998 Distinct Maturational Stages Lead to Different Fates of Pathologic and Protective Allergen-Specific CD4+ memory T Cells during Specific Immunotherapy E. WAMBRE1, J. H. DeLong1, D. Robinson2, W. W. Kwok1; 1Benaroya Research Institute, Seattle, WA, 2Virginia Mason Medical Center, Seattle, WA. 999 Different Epitopes From The Same Timothy Grass Allergen Can Elicit CD4+ T Cells With Distinct Immune Functions W. W. Kwok1, J. Delong1, S. Till2, D. Robinson3, E. Wambre1; 1Benaroya Research Institute at Virginia Mason, Seattle, WA, 2Imperial College London, London, UNITED KINGDOM, 3Virginia Mason Medical Center, Seattle, WA. 1000 Alternaria Extract Rapidly And Specifically Induces Th2 Differentiation-inducing Cytokine From Normal Human Bronchial Epithelial Cells H. Murai1,2, H. Qi2, A. Kalita2, A. Kurosky2, I. Boldogh2, S. Sur2; 1West Medical center, Jouhoku municipal hospital, Nagoya, Aichi, JAPAN, 2UTMB Galveston, Galveston, TX. 1001 Itraconazole Alters T Cell Deviation, Cytokine Production and Proliferation J. W. Steinke1, L. Liu1, L. Borish1, S. Payne2; 1Asthma and Allergic Diseases Center, Charlottesville, VA, 2Department of Otolaryngology, Charlottesville, VA. 1002 Enhanced CysLT1 Expression In T Cells From House Dust Mite-Allergic Individuals Following Stimulation With Der P1 M. Rola-Pleszczynski, S. Turcotte, M. Thivierge, J. Stankova; Université de Sherbrooke, Sherbrooke, QC, CANADA.

1003 A Decrease of CD3+CD8+ T-cells is Significantly Associated with Atopy, Wheezing and Increased IgE Levels in Young Children G. de Vos1, J. Milush2, J. Aaron1, Y. Pichardo3, R. Nazari1, M. Chin3, D. Serebrisky3, D. Rosenstreich1, D. Nixon2, A. Wiznia1; 1Albert Einstein College of Medicine, Bronx, NY, 2UCSF, San Francisco, CA, 3Jacobi Medical Center, Bronx, NY.

Other topics in MAAI 5210 Session Time: Tuesday, March 22, 2011 9:45:00 AM - 10:45:00 AM

1004 Mechanical Injury Polarizes Skin Dendritic Cells to Elicit a Th2 Response by Inducing Cutaneous TSLP Expression M. K. Oyoshi1, R. P. Larson2,3, S. F. Ziegler3,2, R. S. Geha1; 1 Children’s Hospital Boston, Boston, MA, 2 University of Washington, Seattle, WA, 3Benaroya Research Institute, Seattle, WA. 1005 Calcium-activated Potassium Channel KCa3.1 and Chloride Channels Are Involved in Dendritic Cell Migration to Lymph Nodes Z. SHAO, R. Gaurav, L. Lorence, D. K. Agrawal; Center for Clinical & Translational Science, Creighton University School of Medicine, Omaha, NE, OMAHA, NE. 1006 Attenuated Allergic Airway Inflammation in gp91phox KO Mice is Due to Altered Dendritic Cell Function C. M. Sevin, D. C. Newcomb, M. M. Huckabee, K. Goleniewska, T. S. Blackwell, R. S. Peebles; Vanderbilt University Medical Center, Nashville, TN. 1007 Isotonic Saline Subjected to Taylor-Couette-Poiseuille Flow Demonstrates Anti-Inflammatory Activity In Vitro S. German, S. Ghosh, T. L. Mega, L. M. Burke, M. L. Diegel, A. B. Wood, R. L. Watson; Revalesio Corporation, Tacoma, WA. 1008 Chitinase-like Protein YKL-40 Regulates Hyperoxia-induced Apoptosis In Human Airway Epithelial Cells M. Kim, J. Hong, K. Lee, K. Kim, M. Sohn; Department of Pediatrics and Institute of Allergy, Severance Medical Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF. 1009 Optimization Of Culture Medium And Conditions In The Differentiation Of Mesenchymal Stem Cells Into Airway Epithelial Cells K. Kokubun, D. Pankajakshan, D. K. Agrawal; Center for Clinical and Translational Sciences, Creighton University School of Medicine, Omaha, NE. 1010 Frequency of Circulating iNKT Cells Among Adult Allergic Rhinitis Patients M. Fereidouni1, F. Jabbariazad2, R. Faridhosseini2, A. Varasteh2; 1Birjand University of Medical Sciences, Birjand, IRAN, ISLAMIC REPUBLIC OF, 2Mashhad University of Medical Sciences, Mashhad, IRAN, ISLAMIC REPUBLIC OF. 1011 Impact Of The Intestinal Microbiome On Severe Paramyxoviral Respiratory Infection L. E. Camarda, S. J. Ehlenbach, M. A. Hayward, N. H. Salzman, M. H. Grayson; Medical College of Wisconsin, Milwaukee, WI. 1012 Effects of Curcumin on LPS-induced Nitric Oxide Production from Murine Macrophages and PBMC of Humans with Respiratory Allergic Disease M. Kim, M. Nowakowski, R. Joks; Center for Asthma & Allergy Research, SUNY Downstate Medical Center, Brooklyn, NY.

Abstracts  AB325

1013 Influence of Orally Taken Vitamin C on Histamine Levels and Motion Sickness R. Jarisch1, D. Weyer2, E. Ehlert2, C. Koch3, E. Pinkowski4, P. Jung1, W. Kähler2, R. Girgensohn5, W. Hemmer1, A. Koch2; 1 Floridsdorf Allergy Center, Vienna, AUSTRIA, 2 Schifffahrtmedizinisches Institut der Marine, Kronshagen, GERMANY, 3 Havariekommando, Cuxhaven, GERMANY, 4Schiffsarzt, Pohlheim, GERMANY, 5SanAmt der Bundeswehr, München, GERMANY.

Oral Abstract Session Alternative Therapy 5601 Session Time: Tuesday, March 22, 2011 2:00:00 PM - 3:15:00 PM

1014 The Anti-Asthma Chinese Herbal Formula ASHMI Provides More Persistent Benefits than Dexamethasone in a Murine Asthma Model K. D. Srivastava, H. A. Sampson, X. Li; Pediatric Allergy & Immunology, The Mount Sinai School of Medicine, New York, NY. 1015 TLR2 Agonist Enhances CD8+Foxp3+ Regulatory T cells and Limits Th2 Immune Response during Allergen Immunotherapy C. Lin; Clinical Immunological Center, and College of Medicine, China Medical University and Hospital, Taiwan, Taichung, TAIWAN. 1016 Constituents Isolated from Glycyrrhiza uralensis Inhibit IL-4 and Eotaxin Secretion in vitro C. Liu, N. Yang, B. Liang, R. Wang, Y. Song, X. Li; Pediatric Allergy & Immunology, The Mount Sinai School of Medicine, New York, NY. 1017 The Relationship of Vitamin D and Asthma in Children E. Lewis, C. Fernandez, A. A. Nella, R. Hopp, T. Casale, C. Gallagher; Creighton University Medical Center, Omaha, NE. 1018 Inhibitory Effect of Formononetin Isolated from Ku Shen (Radix Sophorae Flavescentis) on IgE production of B cells T. Slotkin, B. Liang, N. Yang, X. Li; Mount Sinai school of Medicine, New York, NY.

Mechanisms of Allergy 5602 Session Time: Tuesday, March 22, 2011 2:00:00 PM - 3:15:00 PM

1019 Children With Cow’S Milk Allergy Have Reduced Levels Of Invariant Natural Killer T Cells (inkts) That Exhibit A Greater Th2 Responsiveness To Cow’S Milk-derived Sphingomyelin (milk-sm) S. Jynouchi, V. Abraham, J. Spergel, E. Dudeck, R. Saltzman, J. Orange, L. Gober, K. Nichols, A. Cianferoni; Children’s Hospital of Philadelphia, Philadelphia, PA. 1020 Human Dendritic Cells Stimulated with Peanut Extract Express High Levels of RALDH2 and Induce RA-Sensitive Genes in Naïve T Cells B. Ruiter, W. G. Shreffler; Massachusetts General Hospital, Boston, MA.

TUESDAY

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

AB326 Abstracts

1021 Il-13 Receptor Alpha 1 Is Expressed On T Cells In Vivo And Il-13 Regulates RSV-Induced Il-17A Production In STAT1-/Mice M. G. Boswell, D. C. Newcomb, M. M. Huckabee, K. Goleniewska, S. S. Reiss, R. S. Peebles, Jr.; Vanderbilt University Medical Center, Nashville, TN. 1022 Gene-expression Profiling And Differential Pathways In The Sensitization And Tolerance To Allergens B. Cárdaba1, M. Aguerri1, F. Florido2, D. Montaner3, M. Mata4, J. López-Cacho1, S. Gallardo1, J. Dopazo3, C. Lahoz1; 1 Immunology Department, IIS-Fundación Jiménez DíazCIBERES, Madrid, SPAIN, 2Allergy Department, Hospital Universitario San Cecilio, Granada, SPAIN, 3 Functional Genomics Unit Bioinformatics Department. Centro de Investigación Príncipe Felipe (CIPF), Valencia, SPAIN, 4Genomic Department, Fundación de Investigación, Hospital General Universitario, Valencia, SPAIN. 1023 Heterogeneous IL-5 Expression Defines Two Phenotypically Distinct Human Th2 Subpopulations B. Upadhyaya, Y. Yin, C. Prussin; NIAID/NIH, Bethesda, MD.

Factors That Drive the IgE Response 5603 Session Time: Tuesday, March 22, 2011 2:00:00 PM - 3:15:00 PM

TUESDAY

1024 Characterization of Paecilomyces variotii Allergens B. J. Green, W. R. Rittenour, J. M. Hettick, E. Janotka, D. H. Beezhold; National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV. 1025 IgE Cross-reactivity to Tropomyosins among Patients with Asthma and/or Rhinitis from Brazil: Analysis by Componentbased Allergen Microarray A. C. S. Santos1, G. A. Bardini1, K. S. Santos2, M. C. R. Barbosa1, A. B. R. Santos1, L. K. Arruda1; 1School of Medicine of Ribeirao Preto, Ribeirao Preto, BRAZIL, 2 University of São Paulo School of Medicine, São Paulo, BRAZIL. 1026 Evolution of IgE responses to Bet v 1-like Molecules throughout Childhood: A longitudinal Study in the MAS Birth Cohort L. Hatzler1, A. Buongiovanni1, A. Rohrbach1, A. Dondi1, T. Keil2, S. Lau1, U. Wahn1, P. M. Matricardi1; 1Department of Pediatric Pneumology and Immunology, Charité University Medical Center, Berlin, GERMANY, 2Institute for Social Medicine, Epidemiology, and Health Economics, Charité University Medical Center, Berlin, GERMANY. 1027 Human Skin Equivalents as a Model for the Study of MiteInduced Inflammatory Reactions in the Skin L. G. Arlian, M. S. Morgan; Wright State University, Dayton, OH. 1028 IgE Antibody Binding Sites On Mite Group I Allergens Defined By X-ray Crystallography And Site-directed Mutagenesis A. Pomés1, J. Glesner1, L. D. Vailes1, W. Minor2, M. Chruszcz2, M. D. Chapman1; 1INDOOR Biotechnologies, Inc., Charlottesville, VA, 2University of Virginia, Charlottesville, VA.

J ALLERGY CLIN IMMUNOL FEBRUARY 2011

Urticaria and Angioedema 5604 Session Time: Tuesday, March 22, 2011 2:00:00 PM - 3:15:00 PM

1029 Serum Levels Of Stem Cell Factor And Soluble C-kit Receptor May Be Serologic Surrogate Markers For Aspirin Induced Urticaria J. Kim1, J. Kim1, Y. Lee2, G. Choi1, H. Jin1, E. Hwang1, Y. Ye1, H. Park1; 1 Ajou University School of Medicine, Suwon, KOREA, REPUBLIC OF, 2GF clinic, Seoul, KOREA, REPUBLIC OF. 1030 Prophylaxis with C1 Inhibitor Concentrate before Tooth Extractions in Patients with Hereditary Angioedema P. Staubach, K. Bork, G. Witzke; Department of Dermatology, Mainz, GERMANY. 1031 Ecallantide Antibodies: Clinical Safety and Efficacy Evaluation in Treatment of Acute HAE Attacks H. H. Li1, P. T. Horn2, W. T. Pullman2; 1Institute for Asthma and Allergy, Chevy Chase, MD, 2Dyax, Boston, MA. 1032 Risk of Angioedema following operative and invasive Procedures in Hereditary Angioedema due to C1-inhibitor Deficiency E. Aygören-Pürsün, I. Martinez Saguer, E. Rusicke, W. Kreuz; University Hospital Frankfurt, Frankfurt, GERMANY. 1033 Factors Predicting Success for Chronic Urticaria Patients Treated with Cyclosporine S. M. Hollander, S. S. Joo, H. J. Wedner; Washington University School of Medicine, St. Louis, MO.

Underserved Populations 5605 Session Time: Tuesday, March 22, 2011 2:00:00 PM - 3:15:00 PM

1034 Under-recognition of Food Allergies in Lower Socioeconomic Status (SES) Schools in a Large Urban School District C. M. Davis, C. L. Parker, S. S. Shah; Baylor College of Medicine, Houston, TX. 1035 Association Between Elevated BMI and Poor Asthma Control Among Inner-City Children from the Pittsburgh Area N. Marcotullio1, J. Padden1, D. Gentile2, D. Skoner2; 1Duquesne University School of Pharmacy, Pittsburgh, PA, 2Allegheny General Hospital, Pittsburgh, PA. 1036 Increased Healthcare Resource Utilization despite Lower Disease Severity among Latino Children with Acute Respiratory Illness R. S. Valet, T. Gebretsadik, K. N. Carroll, P. Minton, K. Woodward, Z. Liu, T. V. Hartert; Vanderbilt University School of Medicine, Nashville, TN. 1037 A Community’s Response to Improving Children’s Asthma Care T. Peterson1, M. Kirkwood2, K. L. Meyerson3; 1Helen DeVos Children’s Hospital, Grand Rapids, MI, 2First Steps, Grand Rapids, MI, 3Asthma Network of West Michigan, Grand Rapids, MI. 1038 Perception of Asthma Control in Overweight Inner-city Teens I. A. Awoyinka, K. K. Shanovich, M. Chih, F. McTavish, C. Sorkness, D. Gustafson; University of Wisconsin - Madison, Madison, WI.

Abstracts  AB327

J ALLERGY CLIN IMMUNOL VOLUME 127, NUMBER 2

5606 Session Time: Tuesday, March 22, 2011 2:00:00 PM - 3:15:00 PM

1039 Age-related Differences in the Pathogenesis of Chronic Rhinosinusitis S. J. Hong, B. Han, L. Suh, D. B. Conley, R. Chandra, R. C. Kern, L. C. Grammer, R. P. Schleimer, S. H. Cho; Northwestern Feinberg School of Medicine, Chicago, IL. 1040 Genome-wide Association Study and Integrative Genomic Analysis of Allergic Rhinitis S. Bunyavanich1,2, B. E. Himes1,2, J. M. Brehm3, S. S. Sharma1,2, B. A. Raby1,2, S. T. Weiss1,2; 1Channing Laboratory, Brigham & Women’s Hospital, Boston, MA, 2Harvard Medical School, Boston, MA, 3University of Pittsburgh Medical Center, Pittsburgh, PA. 1041 Nasal Secretion of Cytokines and Inflammatory Mediators in Local and Systemic Allergic Rhinitis C. Rondón1, C. Mayorga2, R. Herrera2, C. Antúnez2, I. Doña2, N. Blanca-López3, G. Canto3, M. Blanca1; 1 Allergy Service Carlos Haya Hospital, Málaga, SPAIN, 2Research Laboratory, Carlos Haya Hospital-Fundación IMABIS, Málaga, SPAIN, 3Allergy Service Infanta Leonor Hospital, Madrid, SPAIN. 1042 VTX-378, A Novel TLR-8 Agonist, Attenuates Nasal Congestion after Ragweed Challenge in Sensitized Beagle Dogs E. G. Barrett1, K. Rudolph1, G. Dietsch2, R. Hershberg2; 1Lovelace Respiratory Research Institute, Albuquerque, NM, 2VentiRx Pharmaceuticals, Inc., Seattle, WA. 1043 Bioinformatic Analysis Of Epithelial Cell Gene Expression In Chronic Rhinosinusitis Identifies Constitutive Differences Between CRSwNP And CRSsNP M. Desrosiers1, L. Mfuna-Endam1, C. Divoy1, A. Filali-Mouhim1, M. Tessier1, V. Mongrain1, Y. Berthiamue1, S. Rousseau2; 1Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montreal, QC, CANADA, 2Meakins-Christie Laboratory, McGill University, Montreal, QC, CANADA.

Airways Disease 5607 Session Time: Tuesday, March 22, 2011 2:00:00 PM - 3:15:00 PM

1044 Reduced Expression Of Prostaglandin E (pge2) Receptor Ep2 On Bronchial Mucosal Leukocytes In Aspirin Sensitive Asthma (asa) Compared With Non-aspirin-sensitive Asthma (nasa) And Healthy Controls (hc) C. J. Corrigan, R. Napoli, Q. Meng, C. Fang, H. F. Wu, K. Tochiki, V. Reay, T. H. Lee, S. Ying; King’s College London, London, UNITED KINGDOM. 1045 Resistin-like Molecule-b (relm-b) Influences Airways Epithelial Remodelling By Inducing Mucin And Transforming Growth Factor-b2 Gene Expression C. Fang1, Q. Meng1, H. F. Wu1, G. Z. Zhang2, X. W. Zhang2, Y. Song2, T. H. Lee1, C. J. Corrigan1, S. Ying1; 1King’s College London, London, UNITED KINGDOM, 2Jilin University, Changchun, CHINA. 1046 Interplay Between TLR2 and TLR4 in the Innate Response to Mycoplasma pneumoniae Identifies a Key Role for IL-10 in Airway Host Defense D. D. Chaplin, C. L. Zindl, T. P. Atkinson, J. Lai; University of Alabama at Birmingham, Birmingham, AL. 1047 Group V Secretory PLA2 Alternative Activation of Macrophages Contributes to Pulmonary Inflammation Induced by House Dust Mite B. Balestrieri, G. Giannattasio, D. Fujioka, S. Ota, H. Katz, J. A. Boyce; Brigham and Women’s Hospital/Harvard Medical School, Boston, MA. 1048 Impaired Lymph-Node Homing of Dendritic Cells (DC) in Allergen-Challenged Surfactant Protein D Deficient (SP-D-/-) Mice is Associated with Lack of Ccr7 and Reduced Expression of Signal Regulatory Protein-Alpha (Sirp-a) L. R. Forbes1,2, C. Koziol-White2, B. Ducka2, M. Fehrenbach2, A. Haczku2; 1Children’s Hospital of Philadelphia, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA.

TUESDAY

Rhinitis/Sinusitis