- Email: [email protected]
SECTION OF THE CORNEA IN HYPOPYON KERATITIS.
81
hospital patient suffering from hemicrania two drops of the solution. In about a minute he became pallid, felt sick and giddy, his forehead was covered with perspiration, and he sank on the bed by which he was standing almost unconscious,his pulse failing so as scarcely to be felt. After the administration of a little ammonia the circulation became more vigorous, and in twenty minutes there was a marked diminution of the pain, and he experienced a great desire to sleep, a luxury of which his sufferings had almost deprived him on previous nights. Mr. Field administered small doses of the drug to several other people, all of whom were distinctly affected by it. Mr. Field’s observations respecting the activity of the drug were also confirmed by Mr. F. Augustus James, a student of University College. He took a single drop of the In the course of a few minutes he one per cent. solution. a as if he were intoxicated. This was sensation experienced quickly followed by a dull aching pain at the back of the head, which was alternately better and worse, each accession becoming more and more severe. It soon extended to the forehead and the back of the neck, in which there was a decided feeling of stiffness. He also experienced some difficulty of deglutition, succeeded by nausea, retching, and flatulence. A profuse perspiration ensued, and in a quarter of an hour the symptoms began to abate, but he continued dull and heavy. His pulse, he found, had risen from 80 to 100. Considerable headache remained, which increased in the after part of the day, so that at six o’clock he was compelled to go to bed. At break of day he was not relieved, but after a few hours’ more sleep he felt quite well again. Mr. G. S. Brady, of Sutherland, obtained very decided results from the administration of large doses of nitroglycerine to a lady suffering from severe facial neuralgia. He gave two minims and a half of Morson’s five per cent. solution in a little water. In the course of two or three minutes she began to complain of sickness and faintness; these rapidly increased; there was for a few minutes unconsciousness accompanied by convulsive action of the muscles of the face, and stertorous breathing. After swallowing some brandy-and-water, she vomited, and the unpleasant symptoms gradually subsided. Mr. Brady also mentions the case of a relative of his, a chemist, who took a drop of the five per cent. solution in water. Shortly afterwards a feeling of sickness and pain at the epigastrium came on, and he left his desk to pace about the shop, thinking to walk off the uncomfortable sensations. Instead of this, they grew worse, and an intolerable sense of oppression and swimming in the head, with spasmodic twitching of the limbs, supervened. He had barely time to call his assistant when he fell back insensible. Cold water was freely dashed over the face, and the unconsciousness soon passed away. No vomiting ensued, but the sensation of sickness lasted for some time. Being greatly interested in this curious controversy, and being quite at a loss to reconcile the conflicting statements of the different observers, or arrive at any conclusion respecting the properties of the drug, I determined to try its action on myself. Accordingly I obtained some one per cent. solution. One afternoon, whilst seeing out-patients, I remembered that I had the bottle in my pocket. Wishing to taste it, I applied the moistened cork to my tongue, and a moment after, a patient coming in, I had forgotten all about it. Not for long, however, for I had not asked my patient half a dozen before I experienced a violent pulsation in my head, and Mr. Field’s observations rose considerably in my estimation. The pulsation rapidly increased, and soon became so severe that each beat of the heart seemed to shake my whole body. I regretted that I had not taken a more opportune moment of trying my experiments, and was afraid the patient would notice my distress, and think that I was either ill or intoxicated. I was quite unable to continue my questions, and it was as much as I could do to tell him to go behind the screen and undress, so that his chest might be examined. Being temporarily free from observation, I took my pulse, and found that it was much fuller than natural, and considerably over 100. The pulsation was tremendous, and I could feel the beating to the The pen I was holding was very tips of my fingers. violently jerked with every beat of the heart. There was a most distressing sensation of fulness all over the body, and I felt as if I had been running violently. I remained quite quiet for four or five minutes, and the most distressing symptoms gradually subsided. I then rose to examine the patient, the exertion of walking across She room intensified the
questions
but
pulsation. I hardly felt steady enough to perform percussion, and determined to confine my attention to auscultation. The act of bending down to listen caused such an intense beating in my head that it was almost unbearable, and each beat of the heart seemed to me to shake not only On resuming my head, but the patient’s body too. my seat I felt better, and was soon able to go on with my work, though a splitting headache remained for the whole afternoon. Were my symptoms due to nervousness or anxiety? Certainly not. I will not say that I discredited Mr. Field’s observations, but after Dr. Harley’s positive asseitions I certainly did not expect to obtain any very definite results from so small a dose. Moreover, at ’the moment of the onset of the symptoms I was engaged in the consideration of another subject, and had forgotten all about the nitro-glycerine. I did nothing to intensify the symptoms, but, on the contrary, should have been only too glad to got rid of them. The headache, I can most positively affirm, was anything but fancy. Since then I have taken the drug some thirty or forty times, but I never care to do so unless I am quite sure that I can sit down and remain quiet for a time, if necessary. It uniformly produces in me the same symptoms, but they are comparatively slight if I refrain from moving about or exertion of any kind. The acceleration of the pulse is very constant, although sometimes it amounts to not more than ten beats in the minute. The temperature remains unaffected. The pulsation is often so severe as to be acutely painful. It jerks the whole body so that a book held in the hand is seen to move quite distinctly at each beat of the heart. The amount of pulsation may be roughly measured by holding a looking-glass in the hand and throwing the reflection into a of the Before taking the drug the bright spot may be kept room. steady, but as soon as the pulsation begins it is jerked violently from side to side. I have taken all doses from one minim to ten, sometimes simply dropped on the tongue, at others swallowed on sugar or in water. I have not ventured to take more than fifteen minims in a quarter of an hour. Once or twice a ten-minim dose has produced less pulsation than I have experienced at other times from a single drop ; but then with the larger quantity one is careful to avoid even the slightest movement. After a five-minim dose I usually experience a certain amount of drowsiness-a lazy contented feel, with a strong disinclination to do anything. (To be continued.)
have
dark corner
SECTION OF THE CORNEA IN HYPOPYON KERATITIS. BY A. RESIDENT
EMRYS-JONES, M.D.,
SURGEON,
MANCHESTER ROYAL EYE HOSPITAL.
CONSIDERABLE discussion has recently taken place as to the value of the above method of treatment, introduced into ophthalmic surgery by Dr. Saemisch in 1871. During the last two years I have taken especial interest in the subject, and have carefully recorded notes of thirty-five cases which occurred in the practice of this hospital, to the medical officers of which I am greatly indebted for valuable assistance in the inquiry; and I now propose to mention briefly the results, as well as the praittical remarks that have suggested themselves to my mind during the course of treatment. Saemisch gives this form of traumatic ulcer the name of Ulcus cornea serpens. The history the patient generally gives is, that he has been struck in the eye with a piece of iron chipping or some other foreign body, and has suffered intense pain, from which he can get no relief. On examination, a small ulcerated cavity, filled with suppurative debris, is found at one spot, with irregular and extending margins and surrounded by a halo of diffuse cornea; a quantity of pus is found in the anterior chamber, which sometimes increases very rapidly, but which at other times becomes effused very slowly. The conjunctiva is red and inflamed; and there is generally iritis, and intense pain due to pressure on the ciliary nerves. body impacted in the cornea or TrgoMMM..—Any elsewhere should be looked for and removed without delay. The pupil should then be dilated, if possible ; and for this purpose we use a strong preparation of atropine with glycerine (introduced into the eye with a camel’s-hair brush fre.
foreign
82 the
and for which I
it will be
formula, subjoin quently), found most useful in breaking up commencing adhesions :as
Sulphate of atropia, thirty-two grains; powdered starch, twenty grains; glycerine, one ounce. (One drachm of the
mixture contains four grains of atropia.) We should endeavour to allay the pain by the administration of morphia by the mouth or (better) hypodermically, and the application of hot chamomile and poppy-head fomentations. Should we succeed in dilating the pupil and relieving the pain, the frequent instillation of atropine drops (two or four grains to an ounce) and application of hot fomentations will suffice. It is important in all these cases to give good food and a moderate amount of stimulants, preferably beer. In a large number of cases, however, this treatment will be found to give no relief, and to prove no check on the destructive ulcerative process which threatens rapidly to destroy the eye; or the condition may be far advanced when it is presented firstto our notice-poultices have been apnumberless lotions have been tried,and often blisters havebeen employed, torenderthealready either case, where still. atropine and fomentationsfail, or where the caseisalready far advanced, bolder measures must be promptly resorted to. The best plan, according to our experience, is to make a bold incision through the lower third of the cornea, extending through its whole breadth, exactly similar to the incision generally made in the modified Graefian extraction of cataract. Saemisch advocated a- limited incision through the ulcer from the sound tissue on the one side to similar tissue on the other side; but our cases prove that this is not essential, or even desirable, unless the ulcer is situated on the lower third. The broad incision most effectually relieve the existing tension, which is one of the most active factors in the causation and propagation of suppuration. Having made the incision, the curdy pus will generally escape without any further manipulation, or with a very little coaxing with a vulcanite spoon ; if not, it must be removed with a pair of Graefe’s straight iris forceps. The patient instantly expresses great relief from pain. He should be sent to bed and kept perfectly quiet in the recumbent posture for a few days. We should watch daily for any signs of reaccumulation of pus, and if any be found, the margins of the incision should be at once separated with a fine No. 7 Weber’s lachrymal probe or the point of a Weber’s knife. Out of the thirty-five cases, it has been only found neces’ sary to reopen the wound once in four cases, twice in only one case, thrice in only one case, and never oftener. Ir judging the result we must, of course, take the condition oi the eye on admission fully into consideration. In twelve oj our cases the anterior chamber was more than half full oi pus, in six the greatest part of the cornea was in a suppurative condition, in four there was the additional com. plication of a large lead opacity. In spite of the aggravated and advanced condition of many of the cases, in twenty-four there resulted very good vision, varying from No.to No. 1( Jager’s test-types; in six fair vision, Nos. 14 to 20 Jager ’
-plied, and leeches pitiable patient more miserable
In
in four
good perception, and in one partial staphyloma (due neglect of patient). In six cases iridectomy was per formed some months later, owing to resulting permanen1 to
opacities.
Remarks.-From careful
analysis of the above cases, thl be claimed for a bold section :— advantages may following 1. It gives instant relief from pain. 2. It provides effectua
relief to the pus.
3. It proves an immediate check to th( ulcerativeprocess. 4. It is the means of restoring usefu vision in apparently hopeless cases. 5. It gives rise to littll or no deformity, and is followed by no ill consequences 6. Iridectomy can be performed with greater advantage: afterwards, if required, from resulting opacities. ON THE
USES AND APPLICATION OF IODOFORM. BY WYNDHAM COTTLE, M.A., M.B., F.R.C.S., SENIOR ASSISTANT SURGEON TO THE HOSPITAL FOR DISEASES OF THE SKIN, BLACKFRIARS.
IN a letter in THE LANCET, signed " M.D.," it is stated that some account of the uses of iodoform, a therapeutic agent the writer finds widely recommended, would be acceptable. As I have employed it largely for some years, I venture to offer a few words on the subject.
syphilitic disof the tongue, iodoform has been highly recom. mended by Mr. Berkeley Hill, and also for naso-pharyngeal affections by Dr. Prosser James. A grain or a grain and a half, with extract of gentian, sarsaparilla, &c., in the form of a pill twice or three times daily, is advised. I have given it in many cases of syphilis. I must, however, confess my experience of iodoform, when administered internally, has not been equally favourable. I did not find the improvement I had hoped for in my patient’s condition, As an internal remedy.-For the later forms of
ease, especially
while the most marked effects of iodine were very often induced-intense frontal pain, coryza, loss of appetite and sickness, with heightened temperature and quickened pulse. In one casa these severe symptoms followed the administra. tion of half a grain twice daily. As a local application.-For some years in America, on the Continent, and in England, iodoform has been a remedy rapidly growing in favour both for venereal and primary syphilitic sores. Its advantages in these cases are attested by the highest authorities. Very useful is it also in most forms of ulceration, whether specific or not, and in almost any situation. It may be applied with advantage to ulcers of the legs, to rupial sores, to buboes that have become open This wounds, to ulcerations of the vagina, uterus, &c. agent has been highly spoken of as an application in cases of post-nasal catarrh, of ulcerations of the throat, of ozoena, whether syphilitic or not. As a parasiticide it is serviceable, many cases of tinea tondens, sycosis, &c., improving under its influence. Most soothing, too, is it generally when used topically to malignant ulcerations. Indolent sinuses may often also be beneficially injected with solutions of iodoform. Two points of clinical importance must, however, be borne in mind in the employment of iodoform. Though a local anodyne, it is in some degree an irritant. It should never, therefore, be applied to an inflamed surface, since it is likely to cause irritation and pain. It is to the indolent ulcer, in which action is absent or deficient, that it acts so beneficially. And, again, iodoform is apt to inflame the sound skin that surrounds the lesion it is intended to benefit, if kept in contact with it for any lengthened period. Many plans have been devised for applying this drug. On ulcers and venereal sores, previously cleaned and dried, it may, when finely powdered, be lightly dusted, a piece of dry lint being laid over it, and the dressing renewed night and morning while the discharge is profuse, once daily being Tannin or fuller’s earth may be afterwards sufficient. mixed with the iodoform in any proportion if it is desired to moderate its action, equal parts of the ingredients being generally prescribed. Iodoform can also readily, by trituration, be made into an ointment with lard or vaseline, or any of the petroleum derivatives, five to twenty grains to an ounce of the base. This mode is especially useful when it is desired to make the application to internal cavities. Iodoform is sparingly soluble in water and glycerine, somewhat more so in alcohol and warm oil, but readily dissolves in ether, and to a still greater degree in chloroform. This property furnishes us with perhaps the most convenient and easy method of application. A solution of one part of iodoform in six to twelve of either of the last-named bodies is painted with a camel’s-hair brush over the surface to which it is desired to apply it. The solvent evaporates, leaving a film of iodoform, and in most cases the process should be repeated once or twice daily. To avoid the pain which this evaporation of the solvent is apt to produce in sensitive parts, such as the nasal fossse, Dr. Woakes advised "iodoformed wool "-that is, finely-carded cottonwool with which an equal weight of the drug has been intimately blended. A piece of this medicated wool is to be placed in the required situation, and allowed to remain there from one to twenty hours. The extremely penetrating and disagreeable odour of iodoform is its chief objection in practice. I find this is best obviated by great care that none of this powerfully-smelling drug is dropped on the patient’s clothes, that when it is as far as possible covered over, and in some degree it may be disguised when made into an ointment by prescribing with it some essential oil. Tannin, also, when mixed with iodoform possesses the peculiar property of in some measure removing its odour. Sa-,,Ile-row, W.
applied
-
hospital patient suffering from hemicrania two drops of the solution. In about a minute he became pallid, felt sick and giddy, his forehead was covered with perspiration, and he sank on the bed by which he was standing almost unconscious,his pulse failing so as scarcely to be felt. After the administration of a little ammonia the circulation became more vigorous, and in twenty minutes there was a marked diminution of the pain, and he experienced a great desire to sleep, a luxury of which his sufferings had almost deprived him on previous nights. Mr. Field administered small doses of the drug to several other people, all of whom were distinctly affected by it. Mr. Field’s observations respecting the activity of the drug were also confirmed by Mr. F. Augustus James, a student of University College. He took a single drop of the In the course of a few minutes he one per cent. solution. a as if he were intoxicated. This was sensation experienced quickly followed by a dull aching pain at the back of the head, which was alternately better and worse, each accession becoming more and more severe. It soon extended to the forehead and the back of the neck, in which there was a decided feeling of stiffness. He also experienced some difficulty of deglutition, succeeded by nausea, retching, and flatulence. A profuse perspiration ensued, and in a quarter of an hour the symptoms began to abate, but he continued dull and heavy. His pulse, he found, had risen from 80 to 100. Considerable headache remained, which increased in the after part of the day, so that at six o’clock he was compelled to go to bed. At break of day he was not relieved, but after a few hours’ more sleep he felt quite well again. Mr. G. S. Brady, of Sutherland, obtained very decided results from the administration of large doses of nitroglycerine to a lady suffering from severe facial neuralgia. He gave two minims and a half of Morson’s five per cent. solution in a little water. In the course of two or three minutes she began to complain of sickness and faintness; these rapidly increased; there was for a few minutes unconsciousness accompanied by convulsive action of the muscles of the face, and stertorous breathing. After swallowing some brandy-and-water, she vomited, and the unpleasant symptoms gradually subsided. Mr. Brady also mentions the case of a relative of his, a chemist, who took a drop of the five per cent. solution in water. Shortly afterwards a feeling of sickness and pain at the epigastrium came on, and he left his desk to pace about the shop, thinking to walk off the uncomfortable sensations. Instead of this, they grew worse, and an intolerable sense of oppression and swimming in the head, with spasmodic twitching of the limbs, supervened. He had barely time to call his assistant when he fell back insensible. Cold water was freely dashed over the face, and the unconsciousness soon passed away. No vomiting ensued, but the sensation of sickness lasted for some time. Being greatly interested in this curious controversy, and being quite at a loss to reconcile the conflicting statements of the different observers, or arrive at any conclusion respecting the properties of the drug, I determined to try its action on myself. Accordingly I obtained some one per cent. solution. One afternoon, whilst seeing out-patients, I remembered that I had the bottle in my pocket. Wishing to taste it, I applied the moistened cork to my tongue, and a moment after, a patient coming in, I had forgotten all about it. Not for long, however, for I had not asked my patient half a dozen before I experienced a violent pulsation in my head, and Mr. Field’s observations rose considerably in my estimation. The pulsation rapidly increased, and soon became so severe that each beat of the heart seemed to shake my whole body. I regretted that I had not taken a more opportune moment of trying my experiments, and was afraid the patient would notice my distress, and think that I was either ill or intoxicated. I was quite unable to continue my questions, and it was as much as I could do to tell him to go behind the screen and undress, so that his chest might be examined. Being temporarily free from observation, I took my pulse, and found that it was much fuller than natural, and considerably over 100. The pulsation was tremendous, and I could feel the beating to the The pen I was holding was very tips of my fingers. violently jerked with every beat of the heart. There was a most distressing sensation of fulness all over the body, and I felt as if I had been running violently. I remained quite quiet for four or five minutes, and the most distressing symptoms gradually subsided. I then rose to examine the patient, the exertion of walking across She room intensified the
questions
but
pulsation. I hardly felt steady enough to perform percussion, and determined to confine my attention to auscultation. The act of bending down to listen caused such an intense beating in my head that it was almost unbearable, and each beat of the heart seemed to me to shake not only On resuming my head, but the patient’s body too. my seat I felt better, and was soon able to go on with my work, though a splitting headache remained for the whole afternoon. Were my symptoms due to nervousness or anxiety? Certainly not. I will not say that I discredited Mr. Field’s observations, but after Dr. Harley’s positive asseitions I certainly did not expect to obtain any very definite results from so small a dose. Moreover, at ’the moment of the onset of the symptoms I was engaged in the consideration of another subject, and had forgotten all about the nitro-glycerine. I did nothing to intensify the symptoms, but, on the contrary, should have been only too glad to got rid of them. The headache, I can most positively affirm, was anything but fancy. Since then I have taken the drug some thirty or forty times, but I never care to do so unless I am quite sure that I can sit down and remain quiet for a time, if necessary. It uniformly produces in me the same symptoms, but they are comparatively slight if I refrain from moving about or exertion of any kind. The acceleration of the pulse is very constant, although sometimes it amounts to not more than ten beats in the minute. The temperature remains unaffected. The pulsation is often so severe as to be acutely painful. It jerks the whole body so that a book held in the hand is seen to move quite distinctly at each beat of the heart. The amount of pulsation may be roughly measured by holding a looking-glass in the hand and throwing the reflection into a of the Before taking the drug the bright spot may be kept room. steady, but as soon as the pulsation begins it is jerked violently from side to side. I have taken all doses from one minim to ten, sometimes simply dropped on the tongue, at others swallowed on sugar or in water. I have not ventured to take more than fifteen minims in a quarter of an hour. Once or twice a ten-minim dose has produced less pulsation than I have experienced at other times from a single drop ; but then with the larger quantity one is careful to avoid even the slightest movement. After a five-minim dose I usually experience a certain amount of drowsiness-a lazy contented feel, with a strong disinclination to do anything. (To be continued.)
have
dark corner
SECTION OF THE CORNEA IN HYPOPYON KERATITIS. BY A. RESIDENT
EMRYS-JONES, M.D.,
SURGEON,
MANCHESTER ROYAL EYE HOSPITAL.
CONSIDERABLE discussion has recently taken place as to the value of the above method of treatment, introduced into ophthalmic surgery by Dr. Saemisch in 1871. During the last two years I have taken especial interest in the subject, and have carefully recorded notes of thirty-five cases which occurred in the practice of this hospital, to the medical officers of which I am greatly indebted for valuable assistance in the inquiry; and I now propose to mention briefly the results, as well as the praittical remarks that have suggested themselves to my mind during the course of treatment. Saemisch gives this form of traumatic ulcer the name of Ulcus cornea serpens. The history the patient generally gives is, that he has been struck in the eye with a piece of iron chipping or some other foreign body, and has suffered intense pain, from which he can get no relief. On examination, a small ulcerated cavity, filled with suppurative debris, is found at one spot, with irregular and extending margins and surrounded by a halo of diffuse cornea; a quantity of pus is found in the anterior chamber, which sometimes increases very rapidly, but which at other times becomes effused very slowly. The conjunctiva is red and inflamed; and there is generally iritis, and intense pain due to pressure on the ciliary nerves. body impacted in the cornea or TrgoMMM..—Any elsewhere should be looked for and removed without delay. The pupil should then be dilated, if possible ; and for this purpose we use a strong preparation of atropine with glycerine (introduced into the eye with a camel’s-hair brush fre.
foreign
82 the
and for which I
it will be
formula, subjoin quently), found most useful in breaking up commencing adhesions :as
Sulphate of atropia, thirty-two grains; powdered starch, twenty grains; glycerine, one ounce. (One drachm of the
mixture contains four grains of atropia.) We should endeavour to allay the pain by the administration of morphia by the mouth or (better) hypodermically, and the application of hot chamomile and poppy-head fomentations. Should we succeed in dilating the pupil and relieving the pain, the frequent instillation of atropine drops (two or four grains to an ounce) and application of hot fomentations will suffice. It is important in all these cases to give good food and a moderate amount of stimulants, preferably beer. In a large number of cases, however, this treatment will be found to give no relief, and to prove no check on the destructive ulcerative process which threatens rapidly to destroy the eye; or the condition may be far advanced when it is presented firstto our notice-poultices have been apnumberless lotions have been tried,and often blisters havebeen employed, torenderthealready either case, where still. atropine and fomentationsfail, or where the caseisalready far advanced, bolder measures must be promptly resorted to. The best plan, according to our experience, is to make a bold incision through the lower third of the cornea, extending through its whole breadth, exactly similar to the incision generally made in the modified Graefian extraction of cataract. Saemisch advocated a- limited incision through the ulcer from the sound tissue on the one side to similar tissue on the other side; but our cases prove that this is not essential, or even desirable, unless the ulcer is situated on the lower third. The broad incision most effectually relieve the existing tension, which is one of the most active factors in the causation and propagation of suppuration. Having made the incision, the curdy pus will generally escape without any further manipulation, or with a very little coaxing with a vulcanite spoon ; if not, it must be removed with a pair of Graefe’s straight iris forceps. The patient instantly expresses great relief from pain. He should be sent to bed and kept perfectly quiet in the recumbent posture for a few days. We should watch daily for any signs of reaccumulation of pus, and if any be found, the margins of the incision should be at once separated with a fine No. 7 Weber’s lachrymal probe or the point of a Weber’s knife. Out of the thirty-five cases, it has been only found neces’ sary to reopen the wound once in four cases, twice in only one case, thrice in only one case, and never oftener. Ir judging the result we must, of course, take the condition oi the eye on admission fully into consideration. In twelve oj our cases the anterior chamber was more than half full oi pus, in six the greatest part of the cornea was in a suppurative condition, in four there was the additional com. plication of a large lead opacity. In spite of the aggravated and advanced condition of many of the cases, in twenty-four there resulted very good vision, varying from No.to No. 1( Jager’s test-types; in six fair vision, Nos. 14 to 20 Jager ’
-plied, and leeches pitiable patient more miserable
In
in four
good perception, and in one partial staphyloma (due neglect of patient). In six cases iridectomy was per formed some months later, owing to resulting permanen1 to
opacities.
Remarks.-From careful
analysis of the above cases, thl be claimed for a bold section :— advantages may following 1. It gives instant relief from pain. 2. It provides effectua
relief to the pus.
3. It proves an immediate check to th( ulcerativeprocess. 4. It is the means of restoring usefu vision in apparently hopeless cases. 5. It gives rise to littll or no deformity, and is followed by no ill consequences 6. Iridectomy can be performed with greater advantage: afterwards, if required, from resulting opacities. ON THE
USES AND APPLICATION OF IODOFORM. BY WYNDHAM COTTLE, M.A., M.B., F.R.C.S., SENIOR ASSISTANT SURGEON TO THE HOSPITAL FOR DISEASES OF THE SKIN, BLACKFRIARS.
IN a letter in THE LANCET, signed " M.D.," it is stated that some account of the uses of iodoform, a therapeutic agent the writer finds widely recommended, would be acceptable. As I have employed it largely for some years, I venture to offer a few words on the subject.
syphilitic disof the tongue, iodoform has been highly recom. mended by Mr. Berkeley Hill, and also for naso-pharyngeal affections by Dr. Prosser James. A grain or a grain and a half, with extract of gentian, sarsaparilla, &c., in the form of a pill twice or three times daily, is advised. I have given it in many cases of syphilis. I must, however, confess my experience of iodoform, when administered internally, has not been equally favourable. I did not find the improvement I had hoped for in my patient’s condition, As an internal remedy.-For the later forms of
ease, especially
while the most marked effects of iodine were very often induced-intense frontal pain, coryza, loss of appetite and sickness, with heightened temperature and quickened pulse. In one casa these severe symptoms followed the administra. tion of half a grain twice daily. As a local application.-For some years in America, on the Continent, and in England, iodoform has been a remedy rapidly growing in favour both for venereal and primary syphilitic sores. Its advantages in these cases are attested by the highest authorities. Very useful is it also in most forms of ulceration, whether specific or not, and in almost any situation. It may be applied with advantage to ulcers of the legs, to rupial sores, to buboes that have become open This wounds, to ulcerations of the vagina, uterus, &c. agent has been highly spoken of as an application in cases of post-nasal catarrh, of ulcerations of the throat, of ozoena, whether syphilitic or not. As a parasiticide it is serviceable, many cases of tinea tondens, sycosis, &c., improving under its influence. Most soothing, too, is it generally when used topically to malignant ulcerations. Indolent sinuses may often also be beneficially injected with solutions of iodoform. Two points of clinical importance must, however, be borne in mind in the employment of iodoform. Though a local anodyne, it is in some degree an irritant. It should never, therefore, be applied to an inflamed surface, since it is likely to cause irritation and pain. It is to the indolent ulcer, in which action is absent or deficient, that it acts so beneficially. And, again, iodoform is apt to inflame the sound skin that surrounds the lesion it is intended to benefit, if kept in contact with it for any lengthened period. Many plans have been devised for applying this drug. On ulcers and venereal sores, previously cleaned and dried, it may, when finely powdered, be lightly dusted, a piece of dry lint being laid over it, and the dressing renewed night and morning while the discharge is profuse, once daily being Tannin or fuller’s earth may be afterwards sufficient. mixed with the iodoform in any proportion if it is desired to moderate its action, equal parts of the ingredients being generally prescribed. Iodoform can also readily, by trituration, be made into an ointment with lard or vaseline, or any of the petroleum derivatives, five to twenty grains to an ounce of the base. This mode is especially useful when it is desired to make the application to internal cavities. Iodoform is sparingly soluble in water and glycerine, somewhat more so in alcohol and warm oil, but readily dissolves in ether, and to a still greater degree in chloroform. This property furnishes us with perhaps the most convenient and easy method of application. A solution of one part of iodoform in six to twelve of either of the last-named bodies is painted with a camel’s-hair brush over the surface to which it is desired to apply it. The solvent evaporates, leaving a film of iodoform, and in most cases the process should be repeated once or twice daily. To avoid the pain which this evaporation of the solvent is apt to produce in sensitive parts, such as the nasal fossse, Dr. Woakes advised "iodoformed wool "-that is, finely-carded cottonwool with which an equal weight of the drug has been intimately blended. A piece of this medicated wool is to be placed in the required situation, and allowed to remain there from one to twenty hours. The extremely penetrating and disagreeable odour of iodoform is its chief objection in practice. I find this is best obviated by great care that none of this powerfully-smelling drug is dropped on the patient’s clothes, that when it is as far as possible covered over, and in some degree it may be disguised when made into an ointment by prescribing with it some essential oil. Tannin, also, when mixed with iodoform possesses the peculiar property of in some measure removing its odour. Sa-,,Ile-row, W.
applied
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