- Email: [email protected]
Serum triglycerides and HDL cholesterol from SHR after evening primrose oil and other polyunsaturated fats
Prostaglandins Leukotrienes and Medicine 22:
173-177, 19%
SSR Beitz,-Werner a?
B888ECPCh,
l!ilmwIwG
FBrster,
Acadeuq of Science8
ToXj.oolog$, Martin-I&her University, PfBpZ-ist P8qU88tS
ABS!LRACT
to
m)
Sixtg male SHR at 4 weeks of age were divided randomly into 4 groups. The semisyntheticdiets were supplementedwith 14 % by weight (I 30 % of energy) of differentvegetablefats: sunfloweroil, evening primrose oil, linseed oil end palm kernel ~BatbieTffe fatty acid compositionof the fats can be seen from . TABLE 1:
FATTY ACID CaBBpoSITION (VOWJBQE IN PER CENT) OF THE OIIBFEDDURINGTHEiDIlWS Sunflower Oil
12:o 14ro 16rO 16:l 18:0 18:l(n-9) 18:2(n-6) 18:3(n-3) 18:3(n-6) n-3/n-6 P/S
mening primrose oil
Linseed oil
palFatkernel
57.0 8,5
0.7 8-5
8.3 1.9 9.4 71.0
6.0 6.0
1.8 14.0
19.0
2.0
19.9
I.5
62.5 9.2 0.08
2.41
3.14 7.92
7.86
0.02
weight&arch, 20% casein The dieta were cornlementedwith 58 % SG# iciestalnmataof mixieand 5 9scelluloses5) am4 oo&tW
i&the &ail a\lif
rala (7) an4 vitaainf8, eegw3iullgritaig Es baealdiet).Systolicblood~HHSW% raa BO method (5).
~;i;t$;W+(SD). Stqtistical
The valuesare mea&t analyseswere perforasduefng
.
174
OOdl
tr
or
175
On the other hand, HDL cholesterolwas markedly increasedafter the EPO-rich diet. Total cholesterolremainedunchanged in all dietary groups. The data presented confirm our revious findings that serun and renal lipids (7,10) are not ch e3 after an LA-rich diet. zc) "fx1e lowering of triglycerides only deoreasedserum triglycerides. by m-3 fatty acids has recently been reviewed (11). A comparisonof various polyunsaturatedfats revealed that and KDL choleEPO had the most renouncedtriglyceride-lowering sterol-raisingefBects. EPO was also most potent in lowering blood reasure in SER (5). Whether this efficacy is connectedwith the %igh percentageof LA and $-linolenicacid of EPO (12) remains to be studied in detail. Nevertheless,from the preventivepoint of view it seems of interestthat blood pressure,serum triglycegs and HDL cholesterolcan most effectivelybe influencedby .
The evcbB
ltaroaeoil was a genrrmxwgift from Dr. D.B. Horrobin, Bfaato search J&titute, YGWxille, Nova Scotia, Canada. The authors are gratefulto Mrs. R. Taraska for secretarial help.
‘fE
I.
Eoffmamn P, Taube
Oh,
Xhter
W. Attenuationof blood
2. Sohoene 101,Reeves VB, Brerretti A. Bff'ectsof dietary kidlinoleio acid oa the bioo~hwia of ~I$w$GP~&~ ney medullae in spontameous3.y Prostaglandin!RUYom~ Res. l-1792, 19kL 3. YcGmgor L, Iioraaain B, ateletfunction and ??
4. Mcqpmon GJ, Box m. diet- limlel~ aaid Anxt.B&r. Hetab. 26;
176
6. Schijlkens BA, Cehril~g D, S&G. priarroee oil, 8 dietaryprcHBt vascularreactivityto ren3.n Prostaglandins, Iaukotr.lyed. 7. SingerP, MoritzV F8rsterD, Voi Zimontkowski S. I&fectof linolei e ssure,lipids,catecholaaines raCs* Ee spontaneous hypertensivs 41: 215-225,193 2. 8. Royer BBE,Ko H. A sim lifiedse&automatedassayfor plasma triglycerides.Ana1yt. Biochem.29: 405-411,1969. 9. Lo s-VirellaMl?,StoneP, Ellis S, ColwellJ& Cholesterol deperminationin high-densi three differentmethods. IO. Singer P, WirthM, G5dickeW, GerikeU, MoritzV, FGrsterD. Changesof arachidonic acid in phosphatidyloholti~~~nt from other lipidsin kidneysof s ntaneously rats afterfeedinga linoleicaci8" -richdiet.hTze ostaglandins, Leukotr.Med. 14: 327-338,IgEM. 11, CoodnightSK, HarrisWS, ConnorWE, Illingworth DR. Polyunsaturatedfat+q acids,hyperlipidemia, and thrombosis. Arteriosclerosis 2: 87-113,1982. 12. HorrobinDF, Ma&u MS, RuangY-S. Ztfectsof essential fatly acidson rostaglandin biosynthesis.Biomed.Biochim. Acta 43: S 114- i!i120, 1984.
177
173-177, 19%
SSR Beitz,-Werner a?
B888ECPCh,
l!ilmwIwG
FBrster,
Acadeuq of Science8
ToXj.oolog$, Martin-I&her University, PfBpZ-ist P8qU88tS
ABS!LRACT
to
m)
Sixtg male SHR at 4 weeks of age were divided randomly into 4 groups. The semisyntheticdiets were supplementedwith 14 % by weight (I 30 % of energy) of differentvegetablefats: sunfloweroil, evening primrose oil, linseed oil end palm kernel ~BatbieTffe fatty acid compositionof the fats can be seen from . TABLE 1:
FATTY ACID CaBBpoSITION (VOWJBQE IN PER CENT) OF THE OIIBFEDDURINGTHEiDIlWS Sunflower Oil
12:o 14ro 16rO 16:l 18:0 18:l(n-9) 18:2(n-6) 18:3(n-3) 18:3(n-6) n-3/n-6 P/S
mening primrose oil
Linseed oil
palFatkernel
57.0 8,5
0.7 8-5
8.3 1.9 9.4 71.0
6.0 6.0
1.8 14.0
19.0
2.0
19.9
I.5
62.5 9.2 0.08
2.41
3.14 7.92
7.86
0.02
weight&arch, 20% casein The dieta were cornlementedwith 58 % SG# iciestalnmataof mixieand 5 9scelluloses5) am4 oo&tW
i&the &ail a\lif
rala (7) an4 vitaainf8, eegw3iullgritaig Es baealdiet).Systolicblood~HHSW% raa BO method (5).
~;i;t$;W+(SD). Stqtistical
The valuesare mea&t analyseswere perforasduefng
.
174
OOdl
tr
or
175
On the other hand, HDL cholesterolwas markedly increasedafter the EPO-rich diet. Total cholesterolremainedunchanged in all dietary groups. The data presented confirm our revious findings that serun and renal lipids (7,10) are not ch e3 after an LA-rich diet. zc) "fx1e lowering of triglycerides only deoreasedserum triglycerides. by m-3 fatty acids has recently been reviewed (11). A comparisonof various polyunsaturatedfats revealed that and KDL choleEPO had the most renouncedtriglyceride-lowering sterol-raisingefBects. EPO was also most potent in lowering blood reasure in SER (5). Whether this efficacy is connectedwith the %igh percentageof LA and $-linolenicacid of EPO (12) remains to be studied in detail. Nevertheless,from the preventivepoint of view it seems of interestthat blood pressure,serum triglycegs and HDL cholesterolcan most effectivelybe influencedby .
The evcbB
ltaroaeoil was a genrrmxwgift from Dr. D.B. Horrobin, Bfaato search J&titute, YGWxille, Nova Scotia, Canada. The authors are gratefulto Mrs. R. Taraska for secretarial help.
‘fE
I.
Eoffmamn P, Taube
Oh,
Xhter
W. Attenuationof blood
2. Sohoene 101,Reeves VB, Brerretti A. Bff'ectsof dietary kidlinoleio acid oa the bioo~hwia of ~I$w$GP~&~ ney medullae in spontameous3.y Prostaglandin!RUYom~ Res. l-1792, 19kL 3. YcGmgor L, Iioraaain B, ateletfunction and ??
4. Mcqpmon GJ, Box m. diet- limlel~ aaid Anxt.B&r. Hetab. 26;
176
6. Schijlkens BA, Cehril~g D, S&G. priarroee oil, 8 dietaryprcHBt vascularreactivityto ren3.n Prostaglandins, Iaukotr.lyed. 7. SingerP, MoritzV F8rsterD, Voi Zimontkowski S. I&fectof linolei e ssure,lipids,catecholaaines raCs* Ee spontaneous hypertensivs 41: 215-225,193 2. 8. Royer BBE,Ko H. A sim lifiedse&automatedassayfor plasma triglycerides.Ana1yt. Biochem.29: 405-411,1969. 9. Lo s-VirellaMl?,StoneP, Ellis S, ColwellJ& Cholesterol deperminationin high-densi three differentmethods. IO. Singer P, WirthM, G5dickeW, GerikeU, MoritzV, FGrsterD. Changesof arachidonic acid in phosphatidyloholti~~~nt from other lipidsin kidneysof s ntaneously rats afterfeedinga linoleicaci8" -richdiet.hTze ostaglandins, Leukotr.Med. 14: 327-338,IgEM. 11, CoodnightSK, HarrisWS, ConnorWE, Illingworth DR. Polyunsaturatedfat+q acids,hyperlipidemia, and thrombosis. Arteriosclerosis 2: 87-113,1982. 12. HorrobinDF, Ma&u MS, RuangY-S. Ztfectsof essential fatly acidson rostaglandin biosynthesis.Biomed.Biochim. Acta 43: S 114- i!i120, 1984.
177